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Herbs, Spices and Their Roles in Nutraceuticals and Functional Foods

Editors

Aurea Biolabs (P) Ltd, Kochi, Kerala, India

Sasikumar Kuappan

R&D Centre, Aurea Biolabs (P) Ltd, Kochi, Kerala, India

Karthik Varma A.C.

R&D Centre, Aurea Biolabs (P) Ltd, Kochi, Kerala, India

Avtar Matharu

University of York, Heslington, United Kingdom

Table of Contents

Cover image

Title page

Copyright

Contributors

Chapter 1. Overview of natural products in nutraceutical industries

1.1. Introduction

1.2. Global nutraceutical market

1 3 Historical perspectives

1.4. Status of natural products–derived nutraceuticals

1.5. Regulation of nutraceutical around the world

1 6 Challenges and future perspectives

1.7. Conclusion

Chapter 2. Curcuma longa

2.1. Introduction

2.2. Phytochemistry and isolation of bioactive components

2.3. Hurdle of bioavailability and matrix design strategies for improving curcumin bioavailability

2.4. Molecular targets of curcuminoids

2.5. Curcuminoids in functional foods

2 6 Different formulations of curcuminoids and their role in nutraceuticals

2.7. Conclusion

Chapter 3. Boswellia serrata

3.1. Introduction

3.2. Use of B. serrata as a nutraceutical or functional food in neurological diseases

3.3. Use of B. serrata as a nutraceutical or functional food in inflammatory diseases

3.4. Use of B. serrata as a nutraceutical or functional food in gastrointestinal diseases

3.5. Use of B. serrata as a nutraceutical or functional food with anticancer properties

3.6. Use of B. serrata as a nutraceutical or functional food in the treatment of diabetes

3.7. Use of B. serrata as a nutraceutical or functional food with antioxidant properties

3.8. Use of B. serrata as a nutraceutical or functional food with antimicrobial properties

3.9. Conclusion and perspectives

Chapter 4. Role of Piper nigrum in functional food and nutraceuticals

4.1. Introduction

4 2 Overview of pepper

4.3. Nutritional and phytonutrient composition of black pepper

4.4. Recommended dosage and quality specifications of P. nigrum

4.5. Functional food and nutraceutical

4.6. Other therapeutic benefits of P. nigrum

4.7. Uses of P. nigrum essential oil

4.8. Culinary and ethnomedical uses of P. nigrum

4.9. Conclusion

Chapter 5. Ocimum sanctum

5.1. Introduction

5.2. Beneficial effects from Ocimum sanctum as a nutraceutical or functional food

5.3. Conclusion and future perspectives

Chapter 6. Role of Moringa oleifera in nutraceuticals and functional foods

6.1. Introduction

6 2 Nutritional value of Moringa oleifera

6.3. Traditional food and potential uses of Moringa oleifera

6.4. Antimicrobial properties

6 5 Anti-inflammatory properties

6.6. Antioxidant properties

6.7. Anticancer properties

6 8 Antidiabetic properties

6.9. Antiasthmatic properties

6.10. Hepatoprotective properties

6 11 Neuroprotective properties

6.12. Conclusion and future directions

Chapter 7. Galangal Roles in nutraceuticals and functional foods

7.1. Galangal and its phytochemistry

7.2. Galangal in various formulations for different applications

7.3. Biological activities of galangal for different nutraceutical applications

7.4. Conclusion and future prospective

Chapter

8.

Bacopa monnieri

8.1. Background

8.2. Plant morphology

8.3. Chemical constituents

8.4. Extraction methods for chemical constituents

8.5. Analytical techniques used for qualitative and quantitative analysis of B monnieri

8.6. Quantitative analysis of bacosides

8.7. Structure elucidation of saponins in B. monnieri

8 8 Biological activities

8.9. Neuroprotection

8.10. Examples of standardized extract of B. monnieri as herbal formulations

8.11. B. monnieri as a nutraceutical in commercial food products

8.12. Future perspectives

Chapter 9. Trigonella foenum graecum

9.1. Introduction

9.2. Morphology of fenugreek

9 3 Chemical constituents

9.4. Roles of fenugreek as nutraceutical

9.5. Fenugreek as functional food

9.6. Conclusion

Chapter 10. Rosmarinus officinalis

10.1. Introduction

10.2. Rosemary oil and their roles in nutraceuticals and functional foods

10.3. Effect of rosmarinic acid in beverage drinks

10.4. Effect of carnosic acid and rosmarinic acid on cognition

10.5. Effect of ursolic acid

10.6. Conclusion and future perspectives

Chapter 11. Phytochemicals and therapeutic potential of Punica granatum L

11.1. Introduction

11.2. Morphology of Punica granatum

11.3. Nutritional and medicinal importance

11.4. Economic importance

11.5. Phytochemicals present in various parts of pomegranate

11.6. Pharmacological activities of pomegranate

11.7. Role of phytoconstituents in the management of environment pollutant

11.8. Applications of P. granatum in nanotechnology

11.9. Industrial uses of pomegranate

11.10. Patents granted on P. granatum

11.11. Pomegranate in clinical trials

11.12. Toxicity of pomegranate

11.13. Conclusion

List of. abbreviation

Chapter 12. Garcinia cambogia

12.1. Introduction

12.2. Phytochemical analysis

12.3. Hydroxycitric acid

12.4. Pharmacological activities and mechanism of action

12.5. Common adulterants

12.6. Future perspectives

12.7. Declaration of interest

Chapter 13. Camellia sinensis

13.1. Introduction

13.2. Phytochemicals

13.3. Pharmacokinetics

13.4. Pharmacological activities

13.5. Conclusion

Chapter 14. Ferula asafoetida

14.1. Introduction

14.2. Chemical constituents

14.3. Pharmacological and therapeutic potentials of asafoetida

14.4. Toxic effects

14.5. Conclusion

14.6. Conflict of interest

Chapter 15. Concise review on Asparagus racemosus and its role as nutraceuticals and functional foods

15.1. Introduction

15.2. Habit and habitat

15.3. Macroscopic and microscopic characterization

15.4. Cultivation of Asparagus racemosus

15.5. Nutritional and traditional medicinal value of Asparagus racemosus

15.6. Pharmacological activities

15.7. Chemical constituents

15.8. Clinical studies

15.9. Adverse effect and precaution

Chapter 16. Cinnamon as a potential nutraceutical and functional food ingredient

16.1. Introduction

16.2. Species

16.3. Composition of cinnamon

16.4. Natural compounds of cinnamon and therapeutic uses

16.5. Other therapeutic benefits

16.6. Advanced glycation end products

16.7. Culinary uses of cinnamon across the globe

16.8. Conclusion

Chapter 17. Myristica fragrans (Hou.)

17.1. Introduction

17.2. Taxonomy

17.3. Morphology and pharmacognostical details of M. fragrans fruit

17.4. Estimation of composition in rind, nutmeg, and mace

17.5. Phytochemistry of M. fragrans fruit

17.6. Extraction and analysis of bioactive components from M. fragrans

17.7. Application of M. fragrans

17.8. Focus on future perspective of nutmeg

17.9. Toxicity aspects of M. fragrans

17.10. Conclusion

Chapter 18. “Ashtawarga”: the wonder medicinal herbs of nature

18.1. Introduction

18.2. Home of Ashtawarga

18.3. Lack of standardization of Ashtawarga plants

18.4. Uses of Ashtawarga plants in traditional and modern system of medicine

18.5. Red list category and criteria

18.6. Conservation actions and strategies for future prospects

Chapter 19. Regulatory aspects of nutraceuticals

19.1. Introduction

19.2. Need for regulatory standards

19.3. Overview on different regulatory bodies

19.4. Conclusion

Chapter 20. Current trends and technologies in nutraceutical industry

20.1. Introduction

20.2. Current trends to drive nutraceutical industry: global scenario

20 3 Technologies in nutraceutical industry

Chapter 21. Future prospective of nutraceutical and functional food with herbs and spices

21 1 Introduction

21.2. Traditional nutraceuticals and products

21.3. Health benefits of nutraceuticals and functional foods

21 4 The global nutraceuticals and functional foods market

21.5. Motivators of nutraceutical and functional foods market

21.6. Present status of nutraceutical and functional foods

21 7 Challenges in the nutraceuticals and functional foods market

21.8. Regulatory and perception issues

21.9. A snapshot of global regulations

21.10. Toxicity potential of nutraceuticals and functional foods

21.11. Future prospects of nutraceuticals and functional foods

21.12. Nutraceuticals/functional foods: the future of intelligent food

21.13. Characteristics of success: daring to win

21.14. Conclusion

Index

Copyright

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Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.

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Contributors

Olufunmilola A. Abiodun, Department of Home Economics and Food Science, University of Ilorin, Ilorin, Nigeria

Beatrice I.O. Ade-Omowaye, Department of Food Science, Ladoke Akintola University of Technology, Ogbomoso, Nigeria

Sajad Ahmad Wani, Islamic University of Science and Technology, Jammu & Kashmir, India

Reem S. Alruhaimi, Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

Augustine Amalraj, R&D Centre, Aurea Biolabs (P) Ltd, Cochin, Kerala, India

Prajya Arya, Islamic University of Science and Technology, Jammu & Kashmir, India

M. Aswini, School of Sciences, Department of Home Science, The Gandhigram Rural Institute-Deemed to be University, Dindigul, Tamil Nadu, India

Parveen Bansal, University Centre of Excellence in Research, BFUHS, Faridkot, Punjab, India

Renu Bansal, Government Medical College, Patiala, Punjab, India

Pamita Bhandari

CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, India

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uar Pradesh, India

Dinesh Chaudhary, Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon, South Korea

Victor Antonio Costa Lima, Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, Brazil

Adegbola O. Dauda, Department of Home Economics and Food Science, University of Ilorin, Ilorin, Nigeria

Leonardo de Liori Teixeira, Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, Brazil

Suman Giri, College of Pharmacy, Daegu Catholic University, Gyeongsangbuk-do, South Korea

Terri Grassby, Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

Vikas Gupta, University Centre of Excellence in Research, BFUHS, Faridkot, Punjab, India

Emad H.M. Hassanein, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University-Assiut Branch, Assiut, Egypt

Md Jawaid Akhtar, Department of Pharmaceutical Chemistry, College of Pharmacy, National University of Science and Technology, Bousher, Muscat, Oman

J.A.A.S. Jayaweera, Department of Microbiology, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Colombo, Sri Lanka

George Joseph, R&D Centre, Aurea Biolabs (P) Ltd, Cochin, Kerala, India

Shintu Jude, R&D Centre, Aurea Biolabs (P) Ltd, Cochin, Kerala, India

Arya Kadukkail Ramanunny, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India

Gunpreet Kaur, University Centre of Excellence in Research, BFUHS, Faridkot, Punjab, India

Shah Alam Khan, Department of Pharmaceutical Chemistry, College of Pharmacy, National University of Science and Technology, Bousher, Muscat, Oman

Bhupinder Kumar, Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, Punjab, India

Pradyuman Kumar, Islamic University of Science and Technology, Jammu & Kashmir, India

Neha Kumari, Islamic University of Science and Technology, Jammu & Kashmir, India

Sachin Kumar Singh, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India

Sasikumar Kuappan, R&D Centre, Aurea Biolabs (P) Ltd, Cochin, Kerala, India

Gopal Lamichhane, College of Pharmacy, Wonkwang University, Jeollabuk-do, South Korea

Janeline Lunghar, School of Sciences, Department of Home Science, The Gandhigram Rural Institute-Deemed to be University, Dindigul, Tamil Nadu, India

Ayman M. Mahmoud

Department of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, United Kingdom Physiology Division, Zoology Department, Faculty of Science, BeniSuef University, Beni-Suef, Egypt

Mukesh Maithani, MRU, VCSG Government Institute of Medical Sciences & Research, Srinagar, Uarakhand, India

Sreejith Mohanan, New Product Development, Plant Lipids Private Limited, Cochin, Kerala, India

Akhila Nair, R&D Centre, Aurea Biolabs (P) Ltd, Cochin, Kerala, India

Jithu Nambukulangara Vijayan, Department of Business Development, Zeon Life Sciences Pvt. Ltd, Sirmour, Himachal Pradesh, India

Samson A. Oyeyinka Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

National Centre for Food Manufacturing, College of Sciences, University of Lincoln, Lincoln, United Kingdom

Adewumi T. Oyeyinka, School of Tourism and Hospitality, College of Business and Economics, University of Johannesburg, Bunting Road Campus, Johannesburg, South Africa

Febin Pappachan, New Product Development, Plant Lipids Private Limited, Cochin, Kerala, India

Vanessa Bonassa Pesse, Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, Brazil

Ariane Leite Rozza, Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, Brazil

Nitisha Sendri

CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, India

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uar Pradesh, India

Amaya Suku, New Product Development, Plant Lipids Private Limited, Cochin, Kerala, India

A. Thahira Banu, School of Sciences, Department of Home Science, The Gandhigram Rural Institute-Deemed to be University, Dindigul, Tamil Nadu, India

Ana Laura Tironi de Castilho, Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, Brazil

C.V. Umesh, Department of Chemistry, MES Ponnani College, Malappuram, Kerala, India

Bincicil Annie Varghese, R&D Centre, Aurea Biolabs (P) Ltd, Cochin, Kerala, India

Karthik Varma A.C., R&D Centre, Aurea Biolabs (P) Ltd, Cochin, Kerala, India

Sheetu Wadhwa, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India

Chapter 1: Overview of natural products in nutraceutical industries

Abstract

Natural products have been serving as a source of food and nutrition since antiquity. Use of herbs, minerals, and animalderived and fermented products as nutrients had been passed on from generations to generation as an integral part of diet in human beings. These agents hold a high market share of the modern nutraceutical market as well. Prebiotics, probiotics, herbal formula, dietary fiber, proteins, and other nutrients derived from natural resources are widely available and hold billions of dollar value in the market. Research and development on this field, regulation by regulatory body around the world, and awareness and “back to nature” trend on customer guide this market to another height. So, natural products–derived nutraceutical can shape future nutraceutical market, and nutraceutical industries should focus on research, innovation, and development in this field to fulfill customer demand and hold good nutraceutical market share.

Keywords

Herbal nutraceutical; Natural products; Nutraceutical industries, Regulation of nutraceuticals

1.1. Introduction

“Nutraceutical,” a term coined by Stephen DeFelice in 1989 has been used interchangeably with functional food and dietary supplements

these days. He defined nutraceutical as “a food (or part of food) that provides medical or health benefits, including the prevention and/or treatment of disease” [1]. This definition consolidates the concept of nutrition with pharmaceuticals to address the saying of Hippocrates, father of medicine, that “let the food be your medicine.” Nutraceuticals are believed to maintain human health by modifying abnormalities and retaining normal physiological function of the body [2].

The dominance of the market with highly processed food and their implication in health due to nutritional imbalances made humans susceptible to many chronic metabolic diseases. Use of nutraceutical to treat/manage those major health problems such as obesity, cardiovascular diseases, cancer, osteoporosis, arthritis, diabetes, and hyperlipidemia has gained popularity these days. Increased awareness of people toward health coupled with research finding that support the health benefit of these foods in the prevention and/or treatment of diseases has caused the nutraceutical market to grow geometrically. This increased demand, and added value of nutraceuticals has made the food industry and nutritionists to focus on the investigation of disease-preventive and curative potential of food products [3].

Diverse products ranging from herbal formula, isolated nutrients, dietary supplement, genetically modified food, and processed products such as fortified cereals and beverages are produced by the food industry, herbal industry, pharmaceutical, and agribusiness/nutritional conglomerates. Research and development for standardization, product development, and clinical trials are focused by these industries to add health claims to produce an impact on consumer sentiments [4].

Natural products and herbal medicine were used since antiquity for treatment and prevention of diseases [5]. Incorporating several functional foods, spices as part of diet had been practiced since long, which was kept in the shade due to the evolution of the modern diet because of industrialization [6]. Now, those concepts are again bringing aention after clinical evaluation of foods and increased consumer interest in buying food with health claims in it [7,8].

y g 1.2. Global nutraceutical market

Basically, the global market of nutraceutical industries is driven by aging populations, consumer awareness, increasing distribution channels, and increasing healthcare cost. The global nutraceutical market valued around 209 billion in 2017 covering vitamins, dietary supplements, functional drinks, and functional foods (Fig. 1.1). This stake of markets is estimated to reach 373 billion by 2025 [9,10 ]. The United States was believed to hold 75.9 billion worth of nutraceutical market share in 2018 with a compound annual growth rate of 5.3%. Similarly, nutraceutical worth in 2019 and 2020 were $382 and $412 billion, respectively [9,11]. In 2021, the global turnover of the nutraceutical market was valued over $275 billion, which is unpredictable growth of nutraceutical industries that was 7.3$ annual growth. Baby boomers and millennials increased interests in sports and energy, weight loss remedies, natural pharmaceutical alternatives, and the aim of increasing life expectancy were the major players driving this growth [10]. Consumer trend to seek functionality in food and beverages has guided the rapid growth of the nutraceutical market. Growth further increased lately as with the outbreak of corona pandemic, as consumers started looking for solutions that will boost immunity, reduce stress and anxiety, and other health and well-being products [12]. Different marketed nutraceuticals have shown in Table 1.1. Digestive health and beautypromoting functional food are garnering interest among the USA consumers as supported by increased number of products in market with added prebiotics, probiotics, and collagen [10]. With the increased interest in the medicinal value of marihuana, cannabidiol (CBD) served as the biggest innovation in the nutraceutical industry. The United States market of CBD is expected to grow to 16 billion by 2025 from 2 billion in 2018 [10].

FIGURE 1.1 Global estimated nutraceutical market share divided into vitamins and dietary supplement, functional drinks and functional food in 2017 (estimated 209 billion totals)[10].

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