Emerging contaminants in the terrestrial-aquatic-atmosphere continuum: occurrence, health risks and

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EmergingContaminantsinthe

Terrestrial-Aquatic-AtmosphereContinuum

EmergingContaminants intheTerrestrial-AquaticAtmosphereContinuum: Occurrence,HealthRisks, andMitigation

WillisGwenzi

ProfessorandLeadResearcher,BiosystemsandEnvironmentalEngineeringResearch Group,UniversityofZimbabwe,MountPleasant,Harare,HarareProvince,Zimbabwe AlexandervonHumboldtFellow,CompetenceCentreforClimateChangeMitigationandAdaptation (CliMA),UniversityofKassel,andtheLeibniz-InstitutfurAgrartechnikundBiookonomie(ATB), Potsdam,Germany

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Dedication

IdedicatethisbooktomybelovedsonVusumuzi Vuso NkosilathiGwenzi andmybeloveddaughterIsabella Isa SibongileGwenzi.

Pleasetakenoteandfollowtheadvice:

(1) Everyidea,nomatterhowseeminglysmallortrivialitmayappearatfirst, shouldbeimmortalizedbywritingitdown.

(2) Don’tjustconsumeorreadbooks,butcreatecontentbywritingyour ownbooks.

Thisbookdoesjustthat,andisdedicatedtoyou!

SectionA

Introductiontoemerging contaminants

1.Emergingcontaminants:Ahandful ofconceptualandorganizing frameworks

WillisGwenzi

1.Introduction 3

2.Nature,industrialapplications,and sourcesofemergingcontaminants 5

2.1Emergingcontaminants5

2.2Novelentities/technologies6

3.Conceptualandorganizing frameworks 7

3.1Theterrestrial-aquatic-atmosphere continuum7

3.2TheSPRI/CMframework8

3.3Eco-hierarchicalorecosystem cascadeframework8

3.4Thehumanfactoror dimension9

3.5Theconceptofenvironmentally relevantconditions10

3.6Emergingcontaminantsandtheir healthrisksintheCOVID-19era11

4.Conceptualframeworksastools forframingandorganizingthe book 12

5.Concludingremarks

2.Emergingcontaminantsinthe terrestrial-aquatic-atmosphere continuum:Aglobalperspective WillisGwenzi,ArtwellKanda,EdgarMuhoyi, andTamukaJ.Mukura

1.Introduction 17

2.Emergingcontaminants 18

2.1Natureandsources18

2.2Environmentaloccurrenceand circulation18

3.Emergingcontaminants:Aglobal perspective 19

3.1Globalindustrialproductionand trade19

3.2Alifecycleperspectiveonemerging contaminants20

3.3Regulatory,institutional,andpolicy frameworks20

3.4Emergingcontaminantsasaglobal healthconcern21

4.Futureperspectivesandoutlook 22

4.1Recommendations22

4.2Researchneeds22

5.Conclusions 22 References 23

SectionB Emergingcontaminantsin terrestrialsystems

3.High-technologyrareearth elementsinthesoil-plantsystem: Occurrence,behaviour,andfate NyaraiM.MupatsiandWillisGwenzi

1.Introduction 29 2.Industrialapplicationsand

2.1Industrialapplications30

2.2Naturalandanthropogenicsourcesof rareearthelementsinsoils31

2.3Anthropogenicsources31

3.OccurrenceofREEsinthesoil-plant system 32

3.1Soilmatrixandporewater32

3.2Soilorganisms37

3.3Plantsandcrops37

4.Biogeochemicalcontrolsandfate ofREEs 39

4.1Biogeochemicalcontrols40

4.2Soil-root-microbialinteractions41

5.Futuredirectionsandperspectives 41

5.1Increasingtheresearchfootprintof low-incomecountriesinREEs41

5.2InteractiveeffectsofREEsandother essentialplantelements42

5.3Broadeningthescopeofsoil organismsandREEs42

5.4Biotransformationinsoiltrophic system42

5.5REEsbehaviourandfateinvarious soils42

6.Conclusionsandoutlook 42 References 43

4.(Micro)plasticsinthesoilsystem: Occurrence,behaviour,fate,and futuredirections

WillisGwenzi,MunyaradziMtisi,and NhamoChaukura

1.Introduction 47

2.Natureandsourcesof(micro)plastics 49

3.Occurrenceof(micro)plasticsinthesoil system 50

3.1Soils50

3.2Soilorganisms54

3.3Microplasticsinplants54

4.Behaviourandfateprocesses 54

4.1Disseminationpathways54

4.2Behaviour56

4.3Fateprocesses57

5.Futureresearchdirectionsand

5.1Microplasticpollution:Aperspective onlow-incomeversusdeveloped countries57 5.2Futureresearchdirections58

SectionC

5.Occurrenceandbehaviourof emergingorganiccontaminantsin aquaticsystems

WillisGwenzi,NhamoChaukura, NorahMuisa-Zikali,KumbiraiMusiyiwa, andCharlesTeta

1.Introduction 67

2.Emergingorganiccontaminants 68

2.1Natureandanthropogenic sources68

2.2Overviewofemerging contaminants70

2.3Emergingcontaminantsdetectedin Africanaquaticsystems74

3.Behaviour,fate,andhumanhealth risks 75

3.1Behaviourandfate75

3.2Humanexposureandhealthrisks75

4.Removalofemergingcontaminants: Opportunitiesandchallenges 77

4.1Commonlyusedmethods77

4.2Advancedoxidationprocesses78

4.3Emergingtechniques78 4.4Economicconsiderations79

6.Anthropogenicrareearthelements inaquaticenvironments: Occurrence,behaviour,andfate

TerrenceWengaandWillisGwenzi

1.Introduction

2.Sourcesandoccurrence

2.1Overviewofindustrial applications88

2.2Occurrenceinaquaticsystems89

3.Behaviourandfateinaquatic systems 92

3.1Dissemination/transferprocesses92

3.2Biogeochemicalbehaviourand fate93

3.3Behaviourandfateinwastewaterand watertreatmentsystems94

4.Futureperspectivesandknowledge

7.(Micro)plasticsinaquaticsystems: Currentresearchfocalareas, under-studiedmatrices,andfuture directions

1.Introduction 103

2.(Micro)plasticsinaquaticsystems 110

2.1Asummaryoftheevidence110

2.2Currentfocalresearchareas111

2.3Rationalefortheresearchtrends112

2.4(Micro)plasticresearchandthe ‘Matthew’orbandwagoneffect113

3.Futureresearchdirections:Ten(10)key knowledgegapson(micro)plasticsin aquaticsystems 114

3.1(Micro)plasticsindeepmarine systems114

3.2Stratification/depthvariationof (micro)plasticsinaquatic systems114

3.3Standardizationofresearch protocols114

3.4Wideningthebioassayorganisms/ species114

3.5Trophictransferandhealthrisksin aquaticsystems115

3.6COVID-19inducedoccurrenceand ecologicalimpactsof(micro) plastics115

3.7Impactsofregulatoryandpolicy interventions115

3.8Comparativebehaviourandfateof various(micro)plastics115

3.9(Micro)plasticemissionfactorsand loadsatnational,regional,and globalscales116

3.10Researchneedsinlow-income regions116

4.Conclusionsandoutlook 117 References 117

8.Antibiotic-resistantbacteriaand antibioticresistancegenesin aquaticsystems:Occurrence, behaviour,andfate

WillisGwenzi,KumbiraiMusiyiwa, LyndaMangori,NhamoChaukura,and AkebeLutherKingAbia

1.Introduction 121

2.Occurrenceofantimicrobialresistancein aquaticsystems 122

2.1Natureofantimicrobial resistance122

2.2Hotspotsourcesandreservoirs123

2.3Occurrenceinaquaticsystems123

3.Behaviourandfateofantimicrobial resistanceinaquaticsystems 124

3.1Abioticfactors124

3.2Bioticfactors126

3.3Antibioticresistanceinaquatic sediments127

4.Removalofantibioticresistancein wastewatertreatmentsystems 128

4.1ChlorinationandUVirradiation128

4.2Advancedprocesses129

4.3Low-costmethodsusedindeveloping countries129

5.Futureperspectivesandconclusions 130

5.1Knowledgegaps130

5.2Conclusionsandoutlook130 Authorcontributions 130 References 130

SectionD

Emergingcontaminantsin atmosphericsystems

9.Air-borneemergingcontaminants: Anunder-studiedreservoiranda potentialhealthrisk?

WillisGwenzi

1.Introduction 139

2.Air-borneemergingcontaminants 140

2.1Whyareair-borneemerging contaminantsrelativelyunderstudied?140

2.2Themechanismsor(bio)physics ofair-borneemerging contaminants140

3.Occurrenceofair-borneemerging contaminants 141

3.1Microplastics141

3.2Antimicrobialresistance143

3.3Emergingsyntheticorganic contaminants144

3.4High-technologyrareearth elements144

3.5Summaryandimplications145

4.Futureresearchdirections 145

5.Conclusionsandoutlook 147 References 148

10.Occurrence,behaviourandfateof airbornemicroplastics

NorahMuisa-ZikaliandMirandaMpeta

1.Introduction 151

2.Occurrence,natureandsources 152

2.1Occurrenceofairborne microplastics152

2.2Characteristicsofairborne microplastics156

2.3Sourcesofairbornemicroplastics157

3.Behaviour,transportandfateofairborne microplastics 159

3.1Degradationofplasticsintheair159

3.2Transportandfate160

4.Futuredirectionsandperspectives 164

4.1Occurrence,natureandsources164

4.2Behaviourandtransport164

4.3Samplingandanalysis165

5.Conclusionsandoutlook 165 References 165

SectionE

Ecologicalhealthrisks

11.Ecologicalhealthrisksofhightechnologyrareearthelements

TinozivaT.SimbanegaviandWillisGwenzi

1.Introduction 171

2.EcologicalhealthrisksofREEs 172

2.1Overviewofoccurrence,and exposureandhealthrisks172

2.2ImpactsofREEsonsoilecology178

2.3ImpactsofREEsonterrestrialplants andcrops184

2.4ImpactsofREEsinexperimental/ laboratoryanimals185

3.Ecologicalhealtheffectsonaquatic organisms 186

3.1Aquaticandmarineplants186

3.2Aquaticandmarineanimals187

3.3EcologicalhealthrisksofREE mixtures187

4.Futureperspectivesandresearch directions 188

4.1EcologicalhealthrisksofREEsin low-incomecountries188

4.2Keyknowledgegaps188

5.Conclusionandoutlook 190 References 190

12.Ecologicalhealthrisksofantibiotic resistance:Aperspectiveonthe evidence,challenges,andresearch needs

WillisGwenzi,AthenaDana,KarYernKam, NorAzimahMohdZain, TinozivaT.Simbanegavi,andPiotrRzymski

1.Introduction 195

2.Materialsandmethods 196

3.Occurrenceandbehaviourofantibiotic resistance 198

3.1Sourcesandoccurrence199

3.2Environmentalbehaviourand fate199

3.3Antibioticresistancemechanisms201

4.Environmentalandecologicalhealth risks 203

4.1Environmentalexposure pathways203

4.2Environmentalandecologicalhealth risks204

5.Futureresearchdirectionsand perspectives 207

5.1Keyknowledgegaps207

5.2Thehierarchicalorecosystem cascadeframeworkasarisk assessmenttool208

5.3Qualitativeandquantitativehealth riskassessment208

5.4Harnessingemergingandnovel monitoringandanalyticaltools209

6.Conclusionandoutlook 209 References 210

13.Ecologicalhealthrisksofemerging organiccontaminants

WillisGwenzi,TinozivaT.Simbanegavi, JerikiasMarumure,andZakioMakuvara

1.Introduction 215

2.Overviewofmethodology 225

3.Emergingorganiccontaminants 225

3.1Natureandsources225

3.2Propertiesandoccurrence227

3.3Behaviourandfate227

3.4IncreaseddischargeofEOCsinduced byCOVID-19228

4.Ecologicalhealthrisksonterrestrial systems 229

4.1Pharmaceuticalsandpersonalcare products229

4.2Endocrinedisruptingchemicals230

4.3Surfactants230

4.4Plasticizersandsolvents230

4.5Flameretardants231

4.6Illicitdrugs231

4.7COVID-19therapeuticdrugs231

5.EcologicalhealthrisksofEOCsinaquatic systems 231

5.1Pharmaceuticalsandpersonalcare products231

5.2Endocrinedisruptingchemicals232

5.3Surfactants232

5.4Plasticsandsolvents232

5.5Flameretardants233

5.6Illicitdrugs233

5.7COVID-19therapeuticdrugs233

5.8Ecologicalhealthrisksofinteraction ofEOCmixturesandotherhealth stressors234

6.Futureperspectivesandresearch directions 234

6.1Ecologicalhealthrisksinlow-income countries234

6.2Keyknowledgegaps235

7.Conclusionandoutlook 236 References 237

14.Occurrenceandecologicalhealth risksofmicroplastics

WillisGwenzi,TinozivaT.Simbanegavi, HilmanIbnuMahdi,NurIzyanWanAzelee, NorahMuisa-Zikali,and SelvasembianRangabhashiyam

1.Introduction 243

2.Environmentalandecologicalhealth risksofmicroplastics 244

2.1Soilphysico-chemicalproperties244

2.2Soilmicrobialandbiochemical processes246

2.3Soilecology246

2.4Plantsandcrops253

3.Ecologicalhealthrisksinaquatic systems 254

3.1Directimpactsofmicroplastics254

3.2Indirectimpactsofmicroplastics:The roleofchemicaladditives255

4.Interactiveeffectsofmicroplasticsand otherhealthstressors 255

4.1Microplasticsandinorganic/organic pollutants255

4.2Microplasticsandantimicrobial resistance261

4.3Microplasticsasasourceof co-selectionpressurefor microbialevolution261

5.Lookingahead:Futureperspectivesand researchdirections 262

5.1Acritiqueandlimitationsofcurrent evidenceonhealthrisks262

5.2Low-incomeversusdeveloped countries:Acomparisonandhandful ofhypotheses263

5.3Comparisonamongstudies:The challengesandacallforstandardized protocols264

5.4Cross-cuttingknowledgegaps264

6.Conclusionandoutlook 266 References 266

SectionF

Humanhealthrisks

15.Rareearthelements:Human exposure,riskfactors,andhealth risks

WillisGwenzi,ZakioMakuvara,and JerikiasMarumure

1.Introduction 273

2.Sourcesandoccurrence 275

2.1Industrialapplications275

2.2HotspotsourcesofREEs276

3.Humanexposurerisks 276

3.1REEoccurrenceinmediarelevantto humanexposure276

3.2Humanexposureroutes277

4.Humanhealthrisks 279

4.1Evidenceonhumanhealthrisks279

4.2Acriticalanalysisoftheevidence284

5.Futuredirectionsand perspectives 285

6.Conclusionsandoutlook 286 References 286

16.Occurrence,humanexposure pathways,andhealthrisksof (micro)plastics

NyaraiM.MupatsiandWillisGwenzi

1.Introduction 291

2.Occurrenceandhumanexposure pathways 292

2.1Environmentaloccurrence292

2.2Humanexposurepathways294

3.Humanhealthrisks 295

3.1Behaviourandfateof(micro)plastics inthehumanbody295

3.2Evidenceonthehumanhealthrisksof (micro)plastics296

3.3(Micro)plasticsasreservoirsoftoxic humancontaminants299

3.4Acritiqueoftheevidence300

4.Alookahead:Futureperspectivesand researchdirections 300

4.1Futureresearchdirections300

4.2Futureperspectivesand challenges300

4.3Futureresearchdirections302

5.Conclusionsandoutlook 303 References 304

17.Theenvironmentalresistome: Humanexposure,healthrisks,and researchneeds

WillisGwenziandMargaretSiyawamwaya

1.Introduction 307

2.Theenvironmentalantibiotic resistome 308

2.1Nature308

2.2Environmentaloccurrence310

2.3Theenvironmentalresistomeasa complexsystem311

3.Humanexposure 311

3.1Riskfactors311

3.2Humanexposure:Acaseofmultiple sources,routesandreceptors312

4.Humanhealthrisks 313

4.1Asummaryandcritiqueofthe evidence313

4.2Acallforempiricalevidence andOne-World-One-Health research314

5.Humanhealthriskassessment:Ahandful offrameworks 315

5.1Qualitativeriskassessment315

5.2Quantitativemicrobialrisk assessment315

5.3Omics-basedriskassessment316

5.4Ariskmitigationframework317

6.Futuredirectionsandperspectives 317

6.1Environmentalandpublichealth surveillanceinlow-income countries317

6.2Estimatingthehumanhealthburden oftheenvironmentalresistome317

6.3Theenvironmentalresistomeasa complexsystem317

6.4Alternativeantibiotictreatment317

6.5Beyondantibiotics:Theneedto considernon-antibioticantimicrobial resistance319

6.6Quantifyingthemagnitudeandextent ofhumanexposure319

6.7Buildingtechnicalandresearch capacityinlow-incomecountries319

7.Conclusionsandoutlook 319 References 320

SectionG Riskassessmentandmitigation

18.Healthriskassessmentand mitigationofemerging contaminants:Acallforan integratedapproach

WillisGwenzi,EdgarMuhoyi,and TamukaJ.Mukura

1.Introduction 325

2.Healthriskassessment 326

2.1Environmentalandpublic surveillancesystems326

2.2Healthriskassessmentprotocols327

3.Thehumanfactor,andregulatoryand policyperspectives 331

3.1Thehumanfactorasadriverof theemergingcontaminants industry331

3.2Softengineeringapproach331

3.3Regulatory,institutionalandpolicy frameworks331

3.4Economicinstrumentstomitigate emergingcontaminantsandtheir healthrisks331

4.Hardengineeringapproach 333

4.1Substitutionandremoval technologies333

4.2Recycling,recovery,reductionand reusetechnologies336

5.Futureresearchdirectionsand perspectives 336

5.1Acallforanintegrated approach338

5.2Knowledgegaps338

6.Conclusionandoutlook 339 References 340

19.Emergingcontaminants: Approachesforpolicyand regulatoryresponsesin low-incomecountries

OluwademiladeFayemiwoand KirstyCarden

1.Introduction 343

2.Theeffectsofemerging contaminants 344

2.1Thehealthburdenofemerging contaminants344

2.2Healthcareinvestmentsandaccessin sub-SaharanAfrica345

2.3Potentialimpactsofemerging contaminantsoneconomic growth346

3.Constraintsaffectingappropriate responses 347

3.1Lackofinstitutionalcapacity347

3.2Framing348

4.Recommendationsforaction 348

4.1Theprecautionaryprinciple348

4.2Fundingandcapacitybuilding349

4.3Strengtheningtheresearch–policy interfaceinLICs350

4.4Newapproachestoframing350

5.Conclusion 350 References 351

20.Remediationtechnologiesfor contaminatedsoilsystems

NhamoChaukura,E.S.Muzawazi, G.Katengeza,andAlaaElDinMahmoud

1.Introduction 353

2.Emergingorganiccontaminants 354

3.Decontaminationmethods 355

3.1Insituandexsitudecontamination methods355

3.2Bioremediation356

3.3Chemicalandphysicalmethods357

4.High-technologyelements 359

4.1Occurrenceofhightechnology elements359

4.2Removaltechniques360

4.3Extractionandrecoveryof high-technologyelements360

5.Mitigationofmicroplasticpollutionand itshealthrisksinsoilsystems 360

6.Antimicrobialresistance 361

7.Conclusionandfutureoutlook 362 References 362

21.Bio-andchemicalsurfactantsfor remediationofemergingorganic contaminants

UtibeA.Ofon,SolomonE.Shaibu, UduakU.Ndubuisi-Nnaji,EduJ.Inam, ImehJ.Okop,GodwinN.Enin, Nnanake-AbasiO.Offiong,and NnamsoD.Ibuotenang

1.Introduction 367

2.Overviewofemergingorganic contaminants 368

3.Overviewofsurfactant-aided remediationtechnologies 369

4.Surfactantsforremediationofemerging contaminants 369

4.1Syntheticchemicalsurfactants369

4.2Plant-derivedsurfactants370

4.3Biosurfactants374

5.Conclusionandoutlook 376 References 376

SectionH Theresearchagenda

22.Ten(10)keyresearchquestionson emergingcontaminantsandnovel entities,andtheirhealthrisks

WillisGwenzi

1.Introduction 383

2.Emergingcontaminantsandnovel entities 384

2.1Emergingcontaminants384

2.2Novelentities/technologies385

3.Cross-cuttingresearchquestions 386

3.1Globalpoolsandfluxesinthe terrestrial-aquatic-atmosphere continuum386

3.2Healthriskprioritization andrankingofemerging contaminantsandnovelentities386

3.3Acallforstandardizationof protocolstoenableglobalsynthesis ofdata386

3.4Globalecologicalhealthburdenand impactsonecosystemgoods, services,andbenefits389

3.5Thehumanfactor,andacallto social/behaviouralscientiststo activelyparticipateinresearchon emergingcontaminants389

3.6Quantitativeevidenceonhuman healthrisksandglobalhumanhealth burdenrelativetootherhealth stressors390

3.7Theneedtoshiftfromend-of-pipe approachestolifecycleassessment tools390

3.8Thehealthrisksofmixtures,andtheir interactionswithotherstressors390

3.9Ecologicalandhumanhealthrisks: Puttinglow-incomecountriesunder thespotlight390

3.10Riskcommunicationand mitigation391

4.Movingaheadonemerging contaminantsandnovelentities 391

5.Concludingremarks 393 References 393

23.Epilogue:Summary,thenextfrontieremergingcontaminants/ novelentities,andalookahead WillisGwenzi

1.Introduction 395

2.Asummaryofthestate-of-the-art 396

2.1Introduction396

2.2Emergingcontaminantsinthe terrestrial–aquatic–atmosphere continuum397

2.3Ecologicalandhealthrisksof emergingcontaminants397

2.4Riskassessmentandmitigation398

2.5Futureresearchneeds398

3.Alookahead:Futureperspectivesand challenges 398

3.1Novelentities:Thenext-frontier emergingcontaminants398

3.2Covid-19-inducedcomplexitiesand emergingcontaminants402

3.3Grandchallenges402

4.Concludingremarksand outlook 403 References 403 Index405

Contributors

Numbersinparenthesesindicatethepagesonwhichtheauthors’ contributionsbegin.

AkebeLutherKingAbia (121),DepartmentofMicrobiology,VendaUniversity,Thohoyando;Environmental ResearchFoundation,Westville,SouthAfrica

NurIzyanWanAzelee (243),SchoolofChemicaland EnergyEngineering,FacultyofEngineering,Universiti TeknologiMalaysia(UTM);InstituteofBioproduct Development(IBD),UniversitiTeknologiMalaysia, Skudai,Johor,Malaysia

KirstyCarden (343),FutureWaterInstitute,Universityof CapeTown,CapeTown,SouthAfrica

NhamoChaukura (47,67,121,353),Departmentof PhysicalandEarthSciences,SolPlaatjeUniversity, Kimberley,SouthAfrica

AthenaDana (195),DepartmentofBiosciences,Facultyof Science,UniversitiTeknologiMalaysia,JohorBahru, Johor,Malaysia

GodwinN.Enin (367),DepartmentofChemistry, UniversityofUyo,Uyo,Nigeria

OluwademiladeFayemiwo (343),FutureWaterInstitute, UniversityofCapeTown,CapeTown,SouthAfrica

WillisGwenzi (3,17,29,47,67,87,103,121,139,171, 195,215,243,273,291,307,325,383,395), DepartmentofSoilScienceandEnvironment,Faculty ofAgriculture,Environment,andFoodSystems;BiosystemsandEnvironmentalEngineeringResearch Group,DepartmentofSoilScienceandAgricultural Engineering;BiosystemsandEnvironmentalEngineeringResearchGroup,DepartmentofAgricultural andBiosystemsEngineering,FacultyofAgriculture, Environment,andFoodSystems,UniversityofZimbabwe,MountPleasant,Harare,Zimbabwe

NnamsoD.Ibuotenang (367),DepartmentofChemistry, UniversityofUyo,Uyo,Nigeria

EduJ.Inam (367),DepartmentofChemistry;International CentreforEnergyandEnvironmentalSustainability Research(ICEESR),UniversityofUyo,Uyo,Nigeria

KarYernKam (195),DepartmentofBiosciences,Faculty ofScience,UniversitiTeknologiMalaysia, JohorBahru,Johor,Malaysia

ArtwellKanda (17),DepartmentofEnvironmental Science,BinduraUniversityofScienceEducation, Bindura,Zimbabwe

G.Katengeza (353),ChemistryDepartment,BinduraUniversityofScienceandTechnology,Bindura,Zimbabwe

HilmanIbnuMahdi (243),PTGlobalAminesIndonesia, KabupatenGresik,EastJava,Indonesia

AlaaElDinMahmoud (353),EnvironmentalSciences Department;GreenTechnologyGroup,Facultyof Science,AlexandriaUniversity,Alexandria,Egypt

ZakioMakuvara (215,273),DepartmentofPhysics, GeographyandEnvironmentalScience,Schoolof NaturalSciences,GreatZimbabweUniversity,Masvingo,Zimbabwe

LyndaMangori (121),DepartmentofEnvironmental ScienceandTechnology,ChinhoyiUniversityofTechnology,Chinhoyi,Zimbabwe

JerikiasMarumure (215,273),DepartmentofPhysics, GeographyandEnvironmentalScience,Schoolof NaturalSciences,GreatZimbabweUniversity,Masvingo,Zimbabwe

NorAzimahMohdZain (195),DepartmentofBiosciences,FacultyofScience,UniversitiTeknologi Malaysia,JohorBahru,Johor,Malaysia

MirandaMpeta (151),EnvironmentalEngineering Department,ChinhoyiUniversityofTechnology, Chinhoyi,Zimbabwe

MunyaradziMtisi (47),BiosystemsandEnvironmental EngineeringResearchGroup,DepartmentofAgriculturalandBiosystemsEngineering,FacultyofAgriculture,Environment,andFoodSystems,University ofZimbabwe,MountPleasant,Harare,Zimbabwe

EdgarMuhoyi (17,325),DepartmentofEconomicsand Development,FacultyofBusinessManagement

SciencesandEconomics,UniversityofZimbabwe, Harare,Zimbabwe

NorahMuisa-Zikali (67,151,243),DepartmentofEnvironmentalScienceandTechnology,SchoolofAgriculturalSciencesandTechnology,ChinhoyiUniversityof Technology,Chinhoyi,Zimbabwe

TamukaJ.Mukura (17,325),DepartmentofEconomics andDevelopment,FacultyofBusinessManagement SciencesandEconomics,UniversityofZimbabwe, Harare,Zimbabwe

NyaraiM.Mupatsi (29,291),BiosystemsandEnvironmentalEngineeringResearchGroup,DepartmentofAgriculturalandBiosystemsEngineering,Facultyof Agriculture,Environment,andFoodSystems,University ofZimbabwe,MountPleasant,Harare,Zimbabwe

KumbiraiMusiyiwa (67,121),DepartmentofCrop ScienceandPostHarvestTechnology,SchoolofAgriculturalSciencesandTechnology,ChinhoyiUniversity ofTechnology,Chinhoyi,Zimbabwe

E.S.Muzawazi (353),ChemistryDepartment,BinduraUniversityofScienceandTechnology,Bindura,Zimbabwe

UduakU.Ndubuisi-Nnaji (367),DepartmentofMicrobiology,UniversityofUyo,Uyo,Nigeria

Nnanake-AbasiO.Offiong (367),InternationalCentre forEnergyandEnvironmentalSustainabilityResearch (ICEESR),UniversityofUyo,Uyo,Nigeria;Collegeof NewEnergyandEnvironment,JilinUniversity, Changchun,People’sRepublicofChina;Departmentof ChemicalSciences,TopfaithUniversity,Mkpatak,Nigeria

UtibeA.Ofon (367),DepartmentofMicrobiology,UniversityofUyo,Uyo,Nigeria

ImehJ.Okop (367),DepartmentofChemistry,Akwa IbomStateUniversity,IkotAkpaden,MkpatEnin, Nigeria

SelvasembianRangabhashiyam (243),Departmentof Biotechnology,SchoolofChemicalandBiotechnology, SASTRADeemedUniversity,Thanjavur,TamilNadu, India

PiotrRzymski (195),DepartmentofEnvironmentalMedicine,PoznanUniversityofMedicalSciences,Poznan, Poland

SolomonE.Shaibu (367),DepartmentofChemistry,UniversityofUyo,Uyo,Nigeria

TinozivaT.Simbanegavi (103,171,195,215,243), DepartmentofSoilScienceandEnvironment,Faculty ofAgriculture,Environment,andFoodSystems;BiosystemsandEnvironmentalEngineeringResearch Group,DepartmentofAgriculturalandBiosystems Engineering,FacultyofAgriculture,Environment, andFoodSystems,UniversityofZimbabwe,Mount Pleasant,Harare,Zimbabwe

MargaretSiyawamwaya (307),DepartmentofPharmacy andPharmaceuticalSciences,FacultyofMedicineand HealthSciences,UniversityofZimbabwe,Harare, Zimbabwe

CharlesTeta (67),FutureWaterInstitute,FacultyofEngineeringandBuiltEnvironment,Universityof CapeTown,CapeTown,SouthAfrica

TerrenceWenga (87),DepartmentofSoilScienceand Environment,FacultyofAgriculture,Environment andFoodSystems,UniversityofZimbabwe, MountPleasant,Harare,Zimbabwe

Editorbiography

Prof.Dr.WillisGwenzi isaprofessorofBiosystemsandEnvironmentalEngineering.HeisanAlexandervonHumboldt Fellowco-hostedbytheCompetenceCentreforClimateChangeMitigationandAdaptation(CliMA),UniversityofKassel, andtheLeibniz-InstitutfurAgrartechnikundBio€ okonomie(ATB),Potsdam,Germany.Heisarecipientofover20merit awards,includingtheprestigiousAlexandervanHumboldtfellowshipforexperiencedresearchers.Heresearchesonenvironmentalremediation,environmentalhydrology,water/wastewatertreatment,emergingcontaminants,antibioticresistance,andenvironmentalepidemiology.Hehaspublishedover100peer-reviewedarticlesandover30bookchapters. Hisseminalpapersonbiochar-basedwatertreatmentsystemsandhigh-technologyrareearthelementsasemergingcontaminantshavebeenratedasHighlyCitedandHotPapersbyWebofScience.Hehassupervisedmorethan20postgraduate researchstudents.Heisaregularmanuscriptreviewerfortopinternationaljournals.Hehasbeenanexternalreviewerfor grantproposalsforinternationalfundingagenciesinEurope,NorthAmerica,andSouthAmerica.WillisholdsaPhD(BiosystemsandEnvironmentalEngineeringfromtheUniversityofWesternAustralia),MSc(WaterResourcesEngineering andManagement),BScHonours(SoilScience),andPostgraduateCertificate(AppliedGroundwaterModelling).

Professor&LeadResearcher,Biosystems&EnvironmentalEngineeringResearchGroup, UniversityofZimbabwe AlexandervonHumboldtFellow,CompetenceCentreforClimateChangeMitigationandAdaptation(CliMA), UniversityofKassel,andtheLeibniz-InstitutfurAgrartechnikundBiookonomie(ATB), Potsdam,Germany

Preface

1Motivationforthebook

Emergingcontaminantsareattractingsignificantinternationalpublic,policy,andresearchattentionduetotheirpotential healthrisks.Existinginformationonemergingcontaminantsiscurrentlyscatteredinarticlesandbooksthatfocusonspecificemergingcontaminantsorasingleenvironmentalcompartmentsuchasaquaticsystems.Theexistingliteratureisalso devoidofacomprehensivebookthatcoversvariousemergingcontaminantsintheterrestrial–aquatic–atmospherecontinuum,andtheirecologicalandhumanhealthrisks.Thefewavailablebooksarealsosilentontheconceptualframeworks thatshouldguideresearchonemergingcontaminants.

Thepresentbookentitled Emergingcontaminantsintheterrestrial-aquatic-atmospherecontinuum:Occurrence,health risks,andmitigation addressesthesegaps.Insummary,thebookprovidesaone-stopcomprehensivesynthesisoftherecent evidenceonemergingcontaminants.Inthisregard,thebookisdesignedtobeahandyfive-in-oneresourcethatbrings togetherinformationonemergingcontaminantswhichwillotherwisebescatteredinfiveormoredifferentbooks.

2Noveltyofthebook

Comparedwithexistingbooksonrelatedtopics,thepresentbookisuniqueinseveralrespectsasit:

(1) coversfourgroupsofemergingcontaminants(syntheticorganicchemicals,microplastics,antibiotic/antimicrobial resistance,andhigh-technologyrareearthelements)intheterrestrial–aquatic–atmospherecontinuumandtheirhuman andecologicalhealthrisks;

(2) presentsanumberofconceptualframeworks,includingtheterrestrial–aquatic–atmospherecontinuum,sourcepathway-receptor-impact/consequence-mitigation(SPRI/CM)model,andecohierarchicalorecosystemcascade frameworktoframeororganizethestructureandcontentofthebook;

(3) appliestheSPRI/CMmodelandconceptofenvironmentallyrelevantconditionsastheorganizingframeworkto provideacomprehensiveunderstandingofthehealthrisksofemergingcontaminants;

(4) introducesanddiscussesforthefirsttimethe‘humanfactor’conceptentailingknowledge,attitudes/perceptions,and practicesasakeyfactorinemergingcontaminantsandtheirhealthrisks;

(5) presentsacritiqueoftheevidenceonthehumanandecologicalhealthrisksofemergingcontaminants,includingacall forquantitativeevidence;

(6) providesacomparativeanalysisoftheemergingcontaminants,exposurescenarios,andriskfactorsindeveloping countriesversustheirdevelopedcounterparts;

(7) providesacriticalanalysisandconcisesummaryoftheevidenceineachchapter,whichisstructuredasastandalone reviewpaper,andaclearroad-mapintothefuturebyhighlightingissuesandfutureresearchdirections;

(8) presentsadedicatedsectionon‘TheResearchAgenda’with‘FutureResearchDirections’and‘Epilogue’comprising 10higher-orderknowledgegaps,andgrandchallengesrelatingtoplanetaryhealth,impactsofCOVID-19,andimpacts ofemergingcontaminantsonglobalecosystems,ecosystemgoods,andservices.

(9) presentsforthefirsttimeseveralchaptersdiscussingthecomplexitiesinducedbyCOVID-19onemergingcontaminantsandtheirhealthrisks.

3Layout/structureofthebook

(1) Thebookisorganizedinasystematicmannercomprisingeightmainsections(A-H),eachcontainingindividual chapters.

(2) Thelanguage,style,andpresentationareapproachableandmeanttoserveawideaudienceincludingtheresearch community,undergraduateandgraduatestudents,decision-andpolicy-makers,andthegeneralpublicwithaninterest inemergingcontaminants.

(3) Thechaptersareeasytoreadandwell-structuredinalogicalorder,withHighlights,Introduction,Maincontent includingasummaryandcriticalanalysisoftheevidence,FutureDirections/Perspectives,Conclusions/Summary, andReferences.

(4) Thebookiswell-illustrated,withatotalofover80figuresandtableswiththesummaryevidenceandcoreideas.

(5) Theintroductorychaptersand‘TheResearchAgenda’withthecross-cutting‘FutureDirections’and‘Epilogue’area must-readforanyoneinterestedingainingaglimpseofthecomplexityandhigher-orderresearchquestionspertaining toemergingcontaminants.

4Targetaudience

Thisbookisamust-haveresourceforanyoneinterestedinenrichingtheirknowledgeonemergingcontaminantsandtheir healthrisksinbothdevelopinganddevelopedcountries.Thebookhassomethingforeveryone,includingunder-graduate andpostgraduatestudents,academics,environmentalandpublichealthpractitioners,environmentalregulatoryagencies, decision-andpolicy-makers,andeventhegeneralpublicinterestedinenrichingtheirunderstandingofemerging contaminants.

Ihopeyouwillenjoythebook,andIwelcomeanysuggestionsforthesecondeditionofthebook.

Acknowledgements

Conceptualizing,synthesizingevidence,writing,editing,andproofreadingascientificbookwithmorethan20chaptersis notatrivialtask.Notevensowhenitisyourfirstbook,andwhenyouarerequiredtoreportforworkonadailybasis.The healthrisksposedbyCOVID-19andtheassociatedlockdownsmadethisbookprojectevenmorechallengingbutinteresting.Severalpeoplecontributedimmenselytomakethisbookprojectasuccess,andIshouldnottaketheirsupportand effortsforgranted.

Ilistthevariousindividualsandorganizationswhosupportedmeinnoparticularorder.

l TheteamatElsevier,particularlySaraValentino(editorialprojectmanager),CandiceJanco(formeracquisitions editor),andGabrielaCapille(currentacquisitionseditor),PaulPrasadChandramohan(ProductionProjectManager), PraveenAnand(Copyrightscoordinator)andseveralothersfortheirunwaveringsupportduringthecourseofthe project.ThanksSaraforoverseeingtheprojectmanagementandprovidingtimelysupportduringthewritingandfinal phaseofthebook.Thanksforsettingthosetightdeadlines,andforadjustingthemwheretherewasneedtodoso.Alotof lessonswerelearntfromyouonhowtomanageabookproject.Iunderstanditwasnotaneasyprojectforbothparties. Yoursupportismostappreciated.

l Myall-weathercolleagueandcollaboratorProf.Dr.ChicgouaNoubactepoftheUniversityofGottingen(Germany)for providingin-kindsupporttotheprojectandforeditingsomeofthebookchapters.Thanksforallthesupport—IhopeI didnotdisappoint.

l TheInternationalFoundationforScience(IFS),Sweden,providedmewithtworesearchgrantsthatmotivatedmywork onemergingcontaminants.Ithankyouforprovidingthesupportandfundingwhichhasopenedseveralopportunities forme,includingthisbookprojectandhopefullyseveralotherstocome.

l Thetwoanonymousreviewersofthebookproposalwhoprovideddetailedcommentsthatgreatlyimprovedthecontent andstructureofthebook.

l Thevariouscontributingauthorswhospentsleeplessnightsbrainstorming,reviewingliterature,andwritingthe chapters.Igreatlyvaluethosewhoagreedtocontributetothebookatashortnotice,andattimesunderverydifficult conditions.Itwasgreatworkingwithyouall.

l Myfamily,son(Vusumuzi Vuso NkosilathiGwenzi)anddaughter(Isabella Isa SibongileGwenzi)forallthein-kind andmoralsupport,andforappreciatingtheneedtoavoiddisturbingmeevenwhenthingsappearedimpossible.Thisone isdedicatedtoyou.

l Mybeloved9-year-olddaughterIsabellaSibongileGwenziwastheonlyfamilymemberwhowasalwaysathome whenIworkedonthebook.IthankherforallthesupportandunderstandingthatIneededtofinishthebook.Thanks Isaforalsoremindingmeandwakingmeuptoworkonthe‘chapters’asyourightlycalledthem.Thanksalsoforthe countdowns!Finally,Ithankyouforfacilitatingaquickdecisiononthecoverpages—yoursuggestionwasspoton. Thanksagainfornotingtheerrorsthatwerenotsoobvioustome.

l AlltheanonymousindividualsororganizationsImighthaveinadvertentlyomittedtomentionbynamewhosupported meinonewayortheother.

Ithankyouall!

SectionA

Introductiontoemerging contaminants

Chapter1

Emergingcontaminants:Ahandful ofconceptualandorganizingframeworks

BiosystemsandEnvironmentalEngineeringResearchGroup,DepartmentofAgriculturalandBiosystemsEngineering,FacultyofAgriculture, Environment,andFoodSystems,UniversityofZimbabwe,MountPleasant,Harare,Zimbabwe

∗ Correspondingauthore-mail:wgwenzi@yahoo.co.uk;wgwenzi@agric.uz.ac.zw

Highlights

l Emergingcontaminantsoccurandcirculateintheterrestrial-aquatic-atmospherecontinuum.

l Thesource-pathway-receptor-impact/consequence-mitigation(SPRI/CM)conceptisdescribed.

l Theeco-hierarchicalorecosystemcascadeconceptisproposedtoexaminehealthrisks.

l Theconceptofenvironmentallyrelevantconditionsanditslimitationsarediscussed.

l Thehumanfactorconceptentailingknowledge,attitudes,andpracticesisdiscussed.

1Introduction

Emergingcontaminants,alsoreferredtoascontaminantsofemergingconcern,continuetoattractresearch,public,andpolicy attentionduetotheirpotentialhealthrisks.Emergingcontaminantsarequitediverse,andincludethefollowingbroadgroups: (1)syntheticorganicchemicals,(2)microplastics,(3)antibiotic/antimicrobialresistance,(4)high-technologyrareearthelements,and(5)nanomaterials/nanotechnology(GwenziandChaukura,2018; Gwenzietal.,2018a,b,2022; Gwenzi,2020a,b, 2021a,b,c; LambertandWagner,2018; Rogowskaetal.,2018; WesterhoffandLo,2009).Thefirstfourgroupsarethefocusof thepresentbook.However,abriefdiscussionofotheremergingcontaminantsalsoreferredtoasnovelentities/technologiesis presentedinthefinalchaptersofthebookonfuturedirectionsandepilogue.Inthepresentchapter,unlessotherwisespecified, thetermemergingcontaminantsisusedbroadlytorefertobothcontaminantsofemergingconcernandnovelentities/technologies.Thisisbecausetheysharesomegenericsimilarities(Fig.1).

Despitethediversityamongstthevariousgroupsofemergingcontaminants,andevenamongstspecificcontaminants withasinglegroup,anumberofgenericsimilaritiesorcharacteristicsexistamongstthem.Forexample,emergingcontaminantsarecurrentlyunregulatedinmostcountriesbecausetheenvironmentalandhumanhealthguidelinelimitsarenot yetdeveloped(GwenziandChaukura,2018; Gwenzi,2020a,b; Petrovicetal.,2003).Thisisbecausetheirhumanand ecologicalhealthrisks,andmechanismsoftoxicityarestillpoorlyunderstood.Untilrecently,theyhavenotbeenincluded inroutineenvironmentalsurveillanceormonitoringprogrammes(GwenziandChaukura,2018; Petrovicetal.,2003).This isbecausetheyoftenoccurinveryloworminuteconcentrationsinthemagnitudeofnanogramsperlitreorkgofenvironmentalmedia(Gwenzi,2020a,b).Suchveryloworminuteconcentrationsrequiredhighlyadvancedandsensitiveanalyticalequipmentwithlowdetectionlimits.Untiljustrecently,suchhigh-precisionandsensitiveanalyticalequipmentwas notreadilyavailableandisstilllackinginmostlow-incomecountries.Previously,thislackofadvancedanalytical equipmentaccountedforthelimitedmonitoringofemergingcontaminantsintheenvironment(GwenziandChaukura, 2018; Petrovicetal.,2003).However,recentadvancesinanalyticalequipment,includingthedevelopmentofhyphenated orcoupledanalyticaltechniquesenablethedetectionandcharacterizationofemergingcontaminantsinvariousenvironmentalmatrices.

Giventhediversityamongstgroupsandevenwithinasinglegroupofemergingcontaminants,adetaileddiscussionof theoccurrence,fate,behaviour,healthrisks,andmitigationofalltheemergingcontaminantsinasinglebookisnot possible.Therefore,thepresentbookfocusesonfourgroupsofemergingcontaminants:(1)syntheticorganicchemicals, (2)high-technologyrareearthelements,(3)microplastics,and(4)antibiotic/antimicrobialresistance.Adetaileddiscussion EmergingContaminantsintheTerrestrial-Aquatic-AtmosphereContinuum. https://doi.org/10.1016/B978-0-323-90051-5.00014-6 Copyright © 2022ElsevierInc.Allrightsreserved. 3

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