Cosmetic science and technology. theoretical principles and applications 1st edition edition kazutam

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ListofContributors

T.Abe TohokuUniversity,Sendai,Japan

H.Ando OkayamaUniversityofScience,Okayama,Japan

M.Ardigo ` SanGallicanoDermatologicalInstitute,Rome, Italy

E.Berardesca SanGallicanoDermatologicalInstitute, IRCCS,Rome,Italy

H.Fukui FUKUIProfessionalEngineerOffice,Yokohama, Japan

M.J.Garcı´a-Celma FacultyofPharmacyandFoodSciences, UniversityofBarcelona(UB)andBiomedicalResearch NetworkingCenter:Bioengineering,Biomaterialsand Nanomedicine(CIBER-BBN),Barcelona,Spain

A.Ghofranian UniversityofCalifornia,SanFrancisco,CA, UnitedStates

D.Grabner UniversityofBayreuth,Bayreuth,Germany

J.Grice TheUniversityofQueensland,Woolloongabba, QLD,Australia

F.Harada LionCorporation,Odawara,Kanagawa,Japan

I.N.Haridass TheUniversityofQueensland,Woolloongabba, QLD,Australia

M.Hatao ShiseidoGlobalInnovationCenter,Yokohama,Japan

I.Hatta NagoyaIndustrialScienceResearchInstitute, Nagoya,Japan

M.Hayase KaoCorporation,Odawara,Japan

S.Herman DiffusionLLC,Totowa,NJ,UnitedStates

T.Himeno KOSE ´ Corporation,Tokyo,Japan

T.Hirao ChibaInstituteofScience,Choshi,Japan

H.Hoffmann UniversityofBayreuth,Bayreuth,Germany

J.Hosoi ShiseidoGlobalInnovationCenter,Yokohama, Japan

P.Huber ZHAWZurichUniversityofAppliedSciences, Wadenswil,Switzerland

O.Ifuku MaruzenPharmaceuticalsCo.,Ltd.,Fukuyama, Hiroshima,Japan

S.Inoue CosmeticHealthScience,GifuPharmaceutical University,Gifu,Japan

T.Iwata Procter&Gamble,SingaporeInnovationCenter, Singapore,Singapore

TJosephLin TJosephLinAssociates,PacificPalisades,CA, UnitedStates

F.Kanda ShiseidoGlobalInnovationCenter,Yokohama,Japan

K.Kikuchi DepartmentofDermatology,TohokuUniversity GraduateSchoolofMedicine,Sendai,Japan

J.Kishimoto ShiseidoGlobalInnovationCenter,Yokohama, Kanagawa,Japan

T.Kitano OHNO&PARTNERS,Tokyo,Japan

H.Kojima NationalInstituteofHealthSciences(NIHS), Tokyo,Japan

Y.Konno KOSE ´ Corporation,Tokyo,Japan

J.Koyama ShiseidoGlobalInnovationCenter,Yokohama, Japan

V.R.Leite-Silva UniversidadeFederaldeSaoPaulo, UNIFESP-DiademaSP,Brasil

B.Lindman LundUniversity,Lund,Sweden

R.Y.Lochhead TheUniversityofSouthernMississipi, Hattiesburg,MS,UnitedStates

P.S.Lopes UniversidadeFederaldeSaoPaulo,UNIFESPDiademaSP,Brasil

A.C.H.R.Machado UniversidadeFederaldeSaoPaulo, UNIFESP-DiademaSP,Brasil

H.I.Maibach UniversityofCalifornia,SanFrancisco,CA, UnitedStates

H.Masaki TokyoUniversityofTechnology,Hachioji,Tokyo, Japan

M.Masuda Consultant,Ninomiya,Kanagawa,Japan

M.Minamino BelleVienusCo.,Ltd.,Osaka,Japan

R.Miyahara ShiseidoGlobalInnovationCenter,Yokohama, Japan

M.Miyake LionCorporation,Tokyo,Japan

S.Nafisi CentralTehranBranch,IAU,Tehran,Iran; UniversityofCalifornia,SanFrancisco,CA,UnitedStates

N.Naito KOSE ´ Corporation,Tokyo,Japan

Y.Nakama KishiKaseiCo.,Ltd,Kanagawa,Japan

N.Nakamura KISHIKASEICO.,LTD.,Yokohama,Japan

Y.Nakazawa ShiseidoGlobalInnovationCenter,Yokohama, Kanagawa,Japan

J.Nikitakis PersonalCareProductsCouncil,Washington, DC,UnitedStates

Y.Nonomura YamagataUniversityGraduateSchoolof ScienceandEngineering,Yonezawa,Japan

F.Nozaki LinbergCo.,Ltd.,Tokyo,Japan

T.Nylander LundUniversity,Lund,Sweden;MidSweden University,Sundsvall,Sweden;NanyangTechnological University,Singapore,Singapore

N.Oguchi-Fujiwara ShiseidoGlobalInnovationCenter, Yokohama,Japan

Biography

KazutamiSakamoto,PhD

KazutamiSakamotoisaformerprofessoroftheFacultyofPharmacyatChibaInstituteofScienceandcurrentlya guestprofessoroftheDepartmentofPureandAppliedChemistry,FacultyofScienceandTechnology,atTokyo UniversityofScience.Hegraduatedfromthemaster’sprogramofAppliedChemistry,SchoolofEngineeringat TohokuUniversityin1971afterfinishinganundergraduateprogramatthesameuniversity.HereceivedhisPhD fromtheFacultyofScienceatTohokuUniversityin1980.In1971,Dr.SakamotojoinedtheCentralResearchLaboratoriesofAjinomotoCo.,Inc.asaresearchchemistandspentmostofhisprofessionalcarrierwiththecompany until2003.DuringhistimewithAjinomoto,Dr.SakamotoworkedonthedevelopmentoftheAjinomoto’sfunctional chemicalproductsespeciallycosmeticingredients.Healsoconductedbasicresearchintheareaofcolloidand interfacialchemistryandskinscience.In2003,heretiredfromAjinomotoandjoinedShiseidoResearchCenterasa ResidentSpecialTechnicalAdvisor,wherehespentthreeyearsconsultingonthecreationandpromotionof Shiseido’snewR&Dprojects.HethenworkedforSeiwaKaseiCo.LTD.asadirectorofR&D.Alongwithhis industrialcareer,Dr.Sakamotohasbeenactiveinresearchandeducationatvariousuniversitiesincluding YokohamaNationalUniversity,ShinsyuUniversity,andTokyoUniversityofScienceasanadjunctprofessor.After retiringfromindustryin2008,hehasbeenexpandinghisacademicactivities.

Dr.Sakamotohasdoneextensiveresearchonthephysicochemicalpropertiesofaminoacid basedchiralmolecules,especiallyoftheirself-assembledconditions,sincethelate1970s.Hisexplorationsofchiralself-assemblies includedmicelles,lyotropicliquidcrystals,whichwerepioneeringstudiesinthe1970s.Thediscoveryoflyotropic cholestericliquidcrystalformedbyacylaminoacidasachiralsurfactantisagoodexampleofthiswork.HiscuriosityregardingthestructureandfunctionsofchiralassemblyledDr.Sakamototocreatechiralmesoporoussilica asasolidmatter,whichwastemplatedfromchirallyotropicliquidcrystalformedbyacylaminoacidasasoftmatter. Hisstudy“Self-organizationofAminoAcid BasedChiralSurfactants:EvaluationofOrganizedStructuresand InteractionswithBiologicalSystem”receivedanawardfromtheJapanOilChemists’Societyin2005.Inthepast 10years,hehasactivelyparticipatedinmanyinternationalconferencesasaninvitedspeaker.Dr.Sakamotowasa chairmanoftheDivisionofColloidandSurfaceChemistryoftheChemicalSocietyofJapanfor2007 08.

RobertY.Lochhead,PhD,FRSC

Along-timeleaderinpolymersforcosmetics,Dr.LochheadiscurrentlyProfessorandDirectorEmeritusof PolymerScienceattheUniversityofSouthernMississippi.HeservedasaprofessorattheSchoolofPolymersand HighPerformanceMaterialsattheUniversityofSouthernMississippi,andhewasdirectorofthatschoolforalmost 2decades.Hisstudentshavewonbestannualnational/internationalpaperawardsfor18ofthe26yearsthathe spentinacademia.Priortojoiningacademia,thefirst25yearsofhiscareerwerespentinindustrialresearchthat rangedfrompolymerandsiliconesynthesistocolloidandsurfacescienceforcosmeticsandpersonalcareproducts andtothemanagementoftherheologyapplicationssegmentofalargehydrophilicpolymerresearchgroup. Dr.Lochheadistheauthorofmorethan100scientificpapersandreviewsandanamedinventoron25patents. Hisinventionshaveenablednewandbettertechnologiesthatbenefitsocietyandtheenvironment.These include:

• Camouflage“makeup”thatprotectspersonnelfromtheballisticthermalfrontsofexplosions

• Stimulus-responsivepolymer surfactantsystemsforpersonalcareandhomecare(thestimulus-responsive coacervateformationthatunderpinsthemechanismofconditioningshampooshasbeennamed“theLochhead Effect”)

Foreword

TokyoUniversityofScience,Chiba,Japan

Ifyoupickedupthisbook,youlikelyhaveaninterestincosmeticsandyoumayfindyourselfstrugglingtofind yourspecificareaofinterestinthisfield,whichinvolvesanumberofdisciplinesincludingnaturalsciences, technologies,andevensocialsciences.Cosmeticsisanexceptionalfieldwherecutting-edgesciencesandtechnologiesarequicklyappliedintoinnovativeproductsdeeplyintegratedwithsocial,cultural,andtraditional lifestyles.Thisbookisstructuredinfoursectionstointroducetheworldofcosmeticsbyintegratingscientificand technologicalaspects: GeneralViewsofCosmeticScienceandTechnology,FundamentalResourcesforCosmetics,PhysicochemicalAspectsandFormulations,andPhysiologicalandDermatologicalAspects.

Weprovidetheessenceneededtolearnwhatcosmeticsare,frombothscientificandtechnologicalperspectives withinterwovencontentsinrelationtobeautyandcare.Youmaybeascientistseekingupdatedknowledgein cosmeticscienceandlookingforthemostadvancedandpracticalinformation,orperhapsyouareanonscientist lookingforreliableandeasilyaccessibleintroductoryinformationwitharobustscientificbasisincosmetics.This bookaimstofulfillsuchneedsbyprovidingwell-integratedcontentwrittenbytheleadingscientistsinthefield.It providesbasicscientificaspectsthatareintegratedintocosmeticsintheareasofmaterialdevelopment,physicochemicalaspectsofformulations,anddermatologicalconcerns.

Iamgratefultoallthecontributorsthatmadethisbookpossiblebyofferingtheirexpertiseonthebasisand applicationofcosmeticscienceandtechnologies.Myheart-filledthanksgotothecoeditors;withoutthemitwould havebeenimpossibletobringthisendeavortofruition.Dr.HowardI.Maibachopenedmyeyesnotonlytothe worldofsciencebutalsoconnectedmewithanewnetworkofpeople.WhenIarrivedinSanFranciscoinlate August1983,IhadnopracticalcommunicationskillsinEnglishandhesokindlyofferedtohelpmeineveryaspect oflivingandworkingintheUnitedStates.Sincethen,Howardhasalwaysbeenmymentor.Dr.RobertY. Lochhead,withwhomIbecameacquaintedthroughacolleagueatAjinomotoUSAInc.,kindlyacceptedascientist fromAjinomototostudyathislabinthemid-1990s.Sincethenwehavebecomeclosefriends.Bobhasbeenkind enoughtovisitandencouragemystudentsatChibaInstituteofScience(CIS)inJapan,afterIopenedmyownlab forcosmeticsciencein2012.MyrelationshipwithDr.YujiYamashitastartedatthebeginningofthe21stcentury. IwasaguestprofessoratProf.HironobuKunieda’slabatthetimeandYujiwasagraduatestudent,andIhave supervisedforhismaster’sdegreethesis.WhenIstartedmynewcareeratCISin2010,Yujiwasapostdoctoral scientistattheSt.MariannaUniversitySchoolofMedicineinJapanafterfinishinghisPhDatBayreuthUniversity inGermanyunderProfessorHeinzHoffmanandhadseveralyearsofexperienceinindustry.IinvitedYujitojoin metoestablishourlab,andYujinowleadsthelabaftermyretirementfromCIS.

Ifeellifeisalwaysfilledwithunexpectedencounterswithpeopleandopportunities,whichgrowintoan interwovennetwork.Inthissense,thisbookisagreatoutcomeofmylongjourney.Ihopereaderswillenjoythis bookandfindanopportunitytoexploretheworldofcosmeticscienceandtechnology,andgofurtherwiththeir ownjourneys.

MyfirstthanksgoestoEmeritusProfessorHiroyukiOhshimaofTokyoUniversityofScience(TUS)and Dr.KostasMarinakisofElsevierB.V.RegisteredOfficewhobroughtthisprojecttome.Onedayinearly2013, Prof.OhshimafoundmeontheplatformofKashiwaStation,whichmanypeopleusetocommutetoTUS.Sincewe werebothmembersoftheDivisionofColloidandSurfaceChemistryatChemicalSocietyJapan,heknewmy backgroundofworkinginindustryandacademia.Heproposedthisprojectwhenitwasstilljustaconceptbrought fromKostas.AtthemeetingwithKostasinNewOrleansattheSpringACSmeetinginApril2013,Kostasinspired metorevealthescientifictreasureshiddendeepinsidethecosmeticcompaniesandthesecretresourcesofcosmetic productsthatbringdreamstoconsumers.Myjourneystartedwiththesetwoencounters.HowardandBobguided mewiththeirexpertiseonhowtoexplorescienceandtechnologyevenfurther,andwithYuji’spatientsupportour

journeyhasfinallyreacheditsgoal.Wehopethisbookopensdoorstoourreadersandhelpsthemstarttheirown expeditions.

IamalsoindebtedtoSarahJ.Watson,editorialmanagerofPhysicalScienceandMariaJ.Bernard,project managerofScienceandTechnologyBooksatElsevierfortheireditorialassistanceandpatience,andtomyson IzumiSakamotoforhiscontributionoftranslatingmanychaptersoriginallywritteninJapanesetoEnglishwhile preservingtheculturalflavorstotheuniversallanguagejustascosmeticsitselfhasanatureofcommonalityand demographicdiversity.

Inclosing,Ioffermyprofoundthanks Tomyteachers,manyfriendswhohaveenrichedmylifeinmorewaysIcanexpress.

TomyfamilywhostoodbymeandsupportedmeinthemanyyearsIlivedintheUnitedStatesandafter resettlinginJapan.IgivespecialthankstomywifeMarikoforalltheloveanddedicationtoourfamily.

November28,2016

manufacturersthatproduceandselltheseproducts.Cosmeticscienceisafoundationtoassuretheconsumersof suchsafetyandfunctionality,butthisfieldmustbeflexibleandconsciousaboutchangesineconomy,socialdemands,consumerpreferences,andvalues.Cosmeticsmustcontinuetosatisfytheirusersbyflexiblychangingto complywithtrendsandchanges.

1.1.2Science-Technology-SocietyBalanceandGeneralistPerceptionsforCorporateOperation

SinceprehistorictimeshumanshaveenjoyedusingfamiliarresourcesprovidedbyMotherNatureasmakeup. Theyenjoyedthecolorsofflowers,savoredtheirscents,thendiscoveredthestickinessofclay,theblacknessofochre andcoal,orthestrikingpresenceofwhiteclayandwereoverwhelmedbythepowerofhues.Astheyinnocently playedamongnature,theyappreciatedallthephenomenaaroundthemwithcuriosityandwithalltheirfivesenses. Intheirplayfulnesstheyfoundthattheirskinfeltrefreshingaftertheyplayedinwater,andtheymimickedanimals playinginmudandfoundthattheirskinbecameevenmorerevived.Duringcoldseasonstheyrealizedthattheoils fromfoodsthatstayedontheirhandsandskinwererathercomfortable.Theyfoundmaterialsfromnaturalenvironments,paintedtheirskinwithinspiration,playedinwaterandmud,andasthisspreadamongtheircommunityit becameacustominsociety,creatingtheoriginofthecultureofcosmetics.Thisplayfulactofmakeupwaspassed downthroughgenerationsascustomsintheircommunityorsocialtraditionsascosmeticculture.

Ashumanbeings,peopleseeksocietyandculture,bettereconomicsandpolitics,andscientifictechnology.To borrowthewordsofLincoln,weseeklife“ofthepeople,bythepeople,forthepeople.”Inordertoachievetothese desires,cosmeticengineersmustbuildtheirfoundationwithnaturalscience,pointtheirheadstowardhumanities andsocialsciences,andkeepamindsettolearnfromthesethreefields(Fig.1.1).Scienceandtechnologycanevolve onlywhenwekeepourmindsopenandaredisciplinedtoseekinformationwithinoverlookedmessagesfromevery momentofunbrokenhistorytofindprologuesforthenextgeneration.Hippocrates’swords“Artislong,lifeis short”isanaphorismtoencouragelearnerstokeeptheirmotivationbecause“medicalskillstakealongtimetomastereventhoughaman’slifeissoshort,”andthisdisciplinecanbeappliedtothescientifictechnologiesofcosmetics. Weallexistinaspaceandtime,orinterfacewherethismomentisjustatransitiontotomorrow.

Allcosmeticscientistsandengineerstodaymustacknowledgetheuniversalnatureofsciencethroughtheirspecifictargetofcosmeticstolinkwisdomandaction.Theyshouldnotbepreoccupiedbyindividualstudiesbutshould alwaysreadthedemandsfromthetimesandsociety,andstandbesidetheconsumersforawarenessonsciencebasedsocialconsciencetohelpcreateasafeandsoundsocietyforallcitizenstoenjoyandappreciate.

Intoday’ssociety,corporateoperationrequiresanoptimalbalanceofscience-technology-society(STS)asatechniquetoadjustthehighlysubdivideddemandsofscienceandsociety.Thismeansthattheartofcosmetic manufacturingmustbecombinedwithallknowledgeofrelatingscientificfieldstoconnectthedotsofoverlapping technologicalservicesthatutilizecosmeticsinsocietyintoanoverlappingsurfaceandbringthemintofruition.Usinginterfacesciencesyntax,thekeytotechnologymanagementisactivatingtheliaisonareaofbothfields(Fig.1.2).

Likeareedwithaflexibleandstrongcore,cosmeticengineersmusthavecosmetictechniquesandknowledgein cosmetologytoanswertothesociety,andalsohaveageneralistmindwithSTSbalancetoutilizetheirskillsand knowledgeinvarioussites.

FIGURE1.2 Science-technology-societybalance.

1.2.1Cosmetics:TrueNonverbalCommunication

“Thehumanbeingisonlyareed,themostfeebleinnature;butthisisathinkingreed”arethewordsofBlaise Pascal.Asanimals,ourspeciesneededtoovercomeourbiologicalweaknesses.Strugglingtoobtainair,water, andfood,humans(andprehumans)wereindirectcompetitionwithwildlife.Theyrealizedtheirweaknessesand chosetoliveincommunitiestothrivethroughharshnaturalenvironmentsandlearnedtocontrolfiretoprotecttheir habitatsovernighttocreateaveilofsecuritybetweenthemandwildlife,successfullymaintainingspacefortheir communitytosurvive.

Biologically,thehumanspeciesisknownas Homosapiens,aspeciesofanimalsthatemergedasanAfricananthropoid.Theirerectbipedalismnarrowedtheirbirthcanals,andtheyadaptedtothischangebytakingofftheirfursand beingbornasprematurenakedapes.1 Thebrainsizeofanewbornisonlyaquarterofthatofanadult,andalthough ittriplesovertheirfirstthreeyears,theinfancyof H.sapiens islongandneedslongparenting.Wearedestinedas neoteniesorpedomorphicbeings,andneedalongperiodtomature.Asneotenies,ourbodieshaveplasticitywhere theycanflexiblyadjustdependingonexperienceevenaftermaturity.Inotherwords,ahumanlifeislifeoflong youthandlatematurity.

Infantscansupporttheirbodyweightandlieontheirbacksevenbeforetheycansee.Theirfacesareinterfaces withtheouterworld,andtheyexpresstheiremotionswithexpressionsandvoicesoflaughsandcries.Eventually theyrealizethattheyarebeingseen,andthefaceshiftstoasocialinterfaceforinterpersonalcommunication.“The eyesarethemirrorofthesoul.”“Eyesspeakmorethanwords.”Theseexpressionsshowthatfacialexpressionscan delivermoreinformationthanwordsasaformofnonverbalcommunicationandarethecenterofbodylanguage.

Infantsshowthemostinnocentformofsympathyandimitationbycryingwhenotherinfantscry,andastheystart tosee,theyreadtheirmother’sexpressiontomaketheirown.Biological H.sapiens learnemotions,expressionsof anger,joy,sadness,andhappiness,andlearnwordstobecomeindividualhumanbeings.Astheycommunicate withtheirsurroundingworldtheygrowintopersonswithsympathyanddiscipline.Althoughhumansinvented andequippedthemselveswithlanguage,theyneverletgoofthecommunicationwiththeirfacialexpressions.

AccordingtoMehrabian’srule,nonverbalinformation,suchastheintonationandloudnessofwords,facialexpressions,andmovementsofthehandsandbody,accountfor93%ofcommunicationandmerely7%aretransmitted throughwords.BorrowingMarshallMcLuhan’swords,“themediumisthemessage,”cosmeticsareapracticeto enhancenonverbalcommunicationasamediumwithamessagetoembellishourstature.

1.2.2Makeup:AnInventionFromthePlayfulHumanNature

Whileworkingtogethertogatherfoodanddistributingthemvoluntarily,orthroughtheirsympathynurturedby raisingprematurechildrenasacommunity,humanscreatedtheirbasisofsociety.Childrenmatureasindividual socialcitizensonlythroughtheblessingsofnature,society,andculture(Fig.1.3).HumanslivedwithMotherNature, madethegroundingsofsecuringlifenecessitiesinsociety,andthenfosteredcultureforamorecivilizedlife.They foundmorethanjoyanddelightintheplayfulnessofcosmetics,andcosmeticsbecameaculture.

Wecreatedourownenvironmentandlearnedtoliveourliveswhileexpressingoursensitiveandversatilesouls withinaninvisiblewallofsocialstructurethatdividesusfromotherwildlifeofMotherNature.Societyisavesselfor thepublic,andcultureistheproductofhumanactivitycreatedbypeoplelivinginsocietystrivingforabetterlife.

Intheirsociallife,humanspasseddownthetraditionofcosmeticsalongwithtraditionsoflifenecessitiesoffood, clothing,andshelterasarelicofculturalchangethatstillcontinuestothisday.Onlywhenhumanevolutionofboth

morphologicalshapeandthebrainwerecombined,weretheywereabletocreatesocietyandculture.Thebody structureof H.sapiens evolvedintoanoptimalformforbipedalism,andalthoughtheywereweakasanimals,their brainsdevelopedsotheycouldflexiblyhandleanysituationthateventuallyallowedthemtocreatethebasisofmoderncivilizationashumans.

Whenthehumanbodystooduprighthumans’throatsbecamelongerandlower,humansgainedtheabilityfor clearvocals.Thebraindevelopedandlanguagewasinvented,andtheycontrolledtheirvocalstopronouncewords andcreatedverbalcommunication.Furlessandnaked-bornhumansfullyutilizedtheirbraintodiscoverandinvent everysingleaspectthatleadstotoday,anddevelopedallsocietiesandculturesonthisplanet.

Theuniverseisatermthatdefinestheentiretyofallmatter,phenomena,andevents,whereasspaceisliterallythe space,ortheunlimitedspaceknownasouterspacewherematterexistsandeventsoccur.Cosmosisanantonymof chaos,andisaconceptofspaceasanentiretyofthecomplexsystemoforder,andmicrocosmospointstohuman beings.Asmicrocosmosahumanbeingisaninsignificantweakbeinginthemacrocosmosandtheentiretyoftheir existenceonGaiaismerelytheresultofalargerorderofmacrocosmos.

Ontheotherhand,H.sapiensisourbiologicalnamethatmeans“wiseman,”andtheyaretheexistencethatdisplaysmultipletalentsonMotherEarthashumanbeings.Althoughthehumanbrainisrelativelylarge,itaccounts forlessthan3%ofthebodymassbutconsumes25%ofourentiremetabolism.Humanbeingsaresocialpersonswho controlthebalanceofindividualityandautonomyandgivediversitytosociety.

Therehavebeenmanyattemptstodescribethediversityandsocial/culturalnatureofhumansusingbiological taxonomy. Homoludens,or“playingman,”expressesthesomewhatfundamentalnatureofsurvival,thatouractions areonlybasedonplayingjustlikeanimals.Purejoyandinnocenthappinessisnottheonlyreasonforouractions, butthisconceptexplainsthatallofourcultureresultsfromthismotivation. Homotechnicus,or“technicalman,”and Homosocius,or“socialman,”definethefoundationsofmoderncivilization,andthepracticeofeconomic-minded Homoeconomicus andpolitical Homopolitics operatemodernsociety.

H.sapiens werenotjustintellects.Intheirculturetheyimplementedmultilateralplayfulelements.Humansfirst satiatedhungerasanimalsbutlearnedtodineandenjoyaccompaniedmeals,andfoundnewwaystocookdelicious foods,andeveninventedgastronomyasaplayfulconceptofacosmosinthestomach.Paintingskinwasarecreationalgamethatevolvedintocosmeticsasasharedritualoracustomandasocialtradition.Asacommunication medium,thecultureofcosmetics,cosmesis,andcosmetologyissupportedbythebeautyofcosmos(systemand order).

In Homoludens,JohanHuizingastates,“Playisolderthanculture,forculture,howeverinadequatelydefined,alwayspresupposeshumansociety,andanimalshavenotwaitedformantoteachthemtheirplaying.Wecansafely assert,even,thathumancivilizationhasaddednoessentialfeaturetothegeneralideaofplay.”2 Theformationof societyitselfispossiblytheresultofwhichwasoriginallyplayingandfrolickingingroups.Nomatterhowwisethe H.sapiens were,itisdoubtfulthatcommunitiesemergedforastrictlylogicalgoal.Presumablytheircustomofeating mealstogetherwasestablishedsimplybecausetheyenjoyedsharingtheirhappinessduringthemeals.Notonlythe actofconsuming,butthejoysandhappinessfromthetasteofgoodfoodortheirsatisfactionofeasinghungerwere theoriginofmeals,andnutritionandhealtharemerelyexplanationsofscientificknowledgeusedbygenerationsfar after.Perhapshumanbeingsareequippedwithaninstinctwheretheyfeeljoyinactionsthatareactuallylogical.No matterwhattheactionis,itseemsthattheoriginofallsocialhabitsarebasedonjoyfulfeelingsfromplaying.Thefun ofnotonlycollectingbutcookingthecollectedfoods,theexcitementofdiscoveringfoodsthattastebetterwhen cookedtogether,ortherulesthatmadecommunicationbetterwheneatingtogethermayhaveledtothesocialmannersorculturesofeatingmealstogether.

Cosmeticsalsofollowedthesamepathofdining.Cosmeticsstartedwithplayingandenjoyingtheactofdecoratingtheirbodies,buteventuallyspreadthroughoutthecommunityandcreatedthecultureofcosmetics.The meaningofcosmeticsasaformofexpressionthatleadstoacceptance,orthepresenceandpowerofcommunication ofcosmeticsledtothehappinessofbeingaccepted,emotionalsupport,orrelief.Andtodayscienceisrevealingthe effectsthatcosmeticsbringtothebodyandmind.

Bothdiningandcosmeticsdifferdependingoncountriesandcultures,andincurrent-dayglobalizationtheynow influenceeachother,openingthedoortoanewera.JapanesecuisineisacceptedinWesterncultures,andWestern recipesarebeginningtouseJapaneseingredients.Intheworldofart,thereisalreadyahistorywhereJapanese Ukiyoe influencedWesternEuropeart,andlikelyWesternEuropeanartinfluencedtraditionalJapaneseart.Globalizationisatwo-wayprocesswhereallsidesaccepttheirdifferencesandformanewbalance,andisanactive phenomenonofculturalinterfaces.

1.3SOCIETYANDTHEFOUNDATIONOFCOSMETICCULTURE

Inordertounderstandhowthecultureofcosmeticswasimplementedasapartofsociety,let’slookintoarather uniquecaseofthecosmeticsinJapan.Many haniwa (archeologicalremainsofclayimages)decoratedwithred makeuphavebeendiscoveredfromthelate3rdcenturytothelate6thcentury,beforethenationwasunified.In Gishi-Wajinden (“RecordsofWei:AnAccountoftheWa,”theoldestrecordmentioningJapan),itwaswrittenthat inChina,peoplewearwhitemakeupwhereasinJapan(or Wa)menwearredmakeupandhaveblacktattoos. Forancientpeople,makeupmayhavebeenareligiousandsacredsymbolfromtheiraweforanimisticspiritsintheir lifeinharshnaturalenvironments.

Duringthemiddleofthe6thcentury,BuddhismwasimportedfromChina,andwhitemakeupspreadamongthe menandwomenintheJapaneseroyalcourt,becomingtheoriginofJapanesemakeup.LaterintheSengokuperiod (theJapanesecivilwarerainmid-15thtoearly17thcentury),makeupspreadfromthenobilitytothenewruling classof Bushi (Japanesefeudallordsandwarriors,alsoknownas Samurai).The Busho (Bushicommanders)went towarriskingtheirlives,andpreparedtoshowtheirdignitywiththeirfinalmakeupiftheyweretoloseandbe decapitatedandgibbeted.Cosmeticswasawaytoshowdeterminationbypurifyingthebody,easingthespirits, anddecoratingtheirsoulswithbravery,andexpressingtheBushi’spride,theirprominenceinsociety,andselfsupport.

Ingeneral,thehistoryofcosmeticsstartedwithbodypaintingandevolvedtopartialmakeup,mostlyontheface. Humansrealizedthepoweroffacialexpressionsincommunication,andfacialmakeupbecameanimportantmediumandtoolforintimatesocialandinterpersonalcommunication.Originallycosmeticswerenotmeantfor splendororglamorousconsuming.Anditwasdefinitelynotforself-satisfactionbyboastingorshowingoff.Selfdecorationwasrecreationtoenhancejoyandtasteforbeauty,andcosmeticsisamethodtoliftourownspirits.Wearingclothes,accessories,makeup allareformsofsocialfashionthatsharpenthebodyandsoultoexpressourselves andsupportourmindsforabettercharactertohumblyreachouttooneanother,andgiveusdirectionforwise judgment.

1.4THECULTUREOFCOSMETICSANDESTABLISHMENTOFCOSMETIC PHILOSOPHY:ACASESTUDYINJAPAN

1.4.1TheEvolutionofJapaneseCosmeticCultureThroughFusionofWesternCultures

andJapaneseTraditionsof Wa

Writtenaround1000BCEduringtheHeianEra,SeiShonagonwroteinheressay MakuraNoSoshi (ThePillowBook) that“Washingmyhair,puttingonmymakeup,andwearingperfumedclothes”arethingsthatliftthespirit.Inan erawhenpeoplecouldnotwashtheirhairoften,shedescribesthattherefreshmentofwashingherhair,puttingon makeup,andwearingclothesperfumedwiththearomaofincensefilledherwithjoyandexcitementwithdelight. Evenintheoldimperialdays,makeup,sanitation,andaromawereallcombinedwithclothing,andoldarchives documentthatfashionwasforenjoyingitsjoyandfeelings.Thefoundationoftheheartofcosmeticsisplayfulness andemotionsofjoyandhappiness.

Cosmeticsspreadtocommonpeopleaftertheirsocietybecamepeacefulandaffluent.InJapan,thiswasafterthe daysofdisorderofthecivilwarera,andwhentheEdoperiod(early17thtomid-19thcentury)broughtpeacefor over200yearsfortownsfolkculturetoflourish.

Humanshavetriedtounderstandthemeaningofcosmeticsasatooltomaketheirliveshappierandhealthierand amediumforcommunicationthroughphilosophyandlogicofhealthandbeauty.InJapan,cosmeticsspreadtocommonpeopleintheEdoperiod200 300yearsago.ThescienceofcosmeticsstartedinJapanintheMeijiperiod, around150yearsagowhenthecountrystudiedfromWesternnationsasastateandpromotedscientific development.

WhentheMeijiperiodstartedin1868andJapanstartedtomodernize,thegovernmentannouncedthateventraditionalcustomswouldbealterediftheydidnotmeetthenewera,andcosmeticmethodsweresubjecttothisnew restriction.ThegovernmentdidnotshowattachmenttothetraditionofsomeJapanese Wa makeupsuchas Ohaguro, whichismakeupofdyeingteethinblack,and Kaki-Mayu-Kesho, whichisshavingeyebrowsanddrawingtheminthe upperforehead,andthesewerepoliticallydiscontinuedtoWesternizethestate.TheemperorcuthishairtoaWesternstyle,andtheempresstookoffhertoothblackening.ThecalendarwaschangedtotheWesternstandardsolar calendar,andthesegreatchangesledtocurrent-dayJapan.

Kaishuwrotethetitlecalligraphy.Thisshowstheimportanceofcosmeticscienceasaleadingtechnologyofthatage. Kosho-hinSeizo-hou (ProductionMethodsofPerfumery)waspublishedin1899,andtheconceptoftoday’sskincare andhaircarewascategorizedas Kesho-hin/HifuSetsuyo-hin/MohatsuSetsuyo-hin (Cosmetics/SkinNourishingItems/ HairNourishingItems).In1943,theMinistryofAgricultureandCommercealsopublished KoryoOyobiKosho-hin (PerfumeryandCosmetics)asagovernmentalreportoftwoyearsofresearchinGermany.

IntheMeijiperiod,underthegovernmentalpolicyfivedomesticexhibitionswereheldinTokyo,Osaka,and Kyotofrom1877to1903,andtherearerecordsthatlipstick,fragrantoils,perfumes,soap,andskintonerswere exhibited.TheTaishogovernmentfollowedtheMeijigovernment’spromotionofthesenewindustries.Inthe 1914TokyoTaishoExhibitionandthe1922PeaceCommemorationTokyoExhibitionheldinUenoPark,cosmetics werethemainexhibitionofthechemicalindustrypavilion,whilecosmeticmanufacturersopenedmanypavilions andrecordsshowtheycontributedtothesuccessoftheexhibitions.TheseexhibitionsarethefoundationofthecosmeticsandperfumeryindustryinJapan,whichwithstoodWorldWarI,theGreatKantoEarthquake,andWorldWar II,andevolvedtothisday.ThisbriefhistoryinJapanshowshowscienceandtechnologycontributedtoeconomic developmentandcreatedavirtuouscirclethatledtofurtherdevelopment,andasengineerswemustkeepinmind whatourstandpointistocreateandkeepthiscircle.

1.6SCIENCE,TECHNOLOGY,ANDSOCIALDEMANDS

1.6.1CorporateResponsibilitiesforAccountabilityinScienceandTechnology

ScienceandtechnologyplayedtheirfirstroleintheworldofcosmeticsinJapannotbycreatingsomethingnew buttostallcosmeticsbyprohibitingtoxinsasacountry.Thebeautifulcolorsincosmeticshadahistoryoftoxic materialsintheirsubstancessuchasredandwhitepigments.Today,consumersdirectlyseekinformationonsafety andeffectiveness.

Engineerstodaymustpossesstheskillsofthetechnologyofcosmeticsaswellasprovideinformationonthetechnologyusedincosmetics.Informationontechnologyisimportantforcorporatemarketingandforsociety,butthe responsibilityoftechnologydoesnotendbyjustprovidinginformation.Tothecommonaudience,scienceisdifficult tounderstand.Engineershavetheresponsibilitytoputeffortsintoscientificeducation.Providinginformationon technologyisaserviceofmarketingthatisbasedonthepremisethatthepeopleunderstandthemcorrectlyso theconsumerscanpurchasetheirproductshappily.Safetyisalsoaconcern,andweliveinanagewherenature alarmsusthattheenvironmentdoesnotguaranteesafety.Thisisalsoanagewhereinformationisfloodedoneffectiveness,oronmanaginghealthyskin,includingsuspiciousinformation.

Ultraviolet(UV)raysinduceskinagingandcanincreasetheriskofskincancer;althoughthisinformationisscientificallycorrect,itmustbecarefullyhandled.Biologicalagingcannotbeavoided,andnoteverybodywillhaveskin cancer.ThisissuerelatescloselytootherfactorssuchasexposuretoUVrays,themelanincontentintheskin,and ethicaldifferences.Aone-sidedstatementwithanimplicitbasisthatUVisevilisnotpropereducation.Thisstatementcouldevenbeafraudtofakescienceandmanipulatesomeonetothewrongpath.Therearealreadysomany peoplewhotodaymisguidedlyfearUVrays.Eventhoughtheremayhavenotbeenanyillintent,sun-careproducts exaggeratethedangerofUVtoboosttheirsales,andthesemarketingtechniquesofimplantingfearusescientificlookingrhetoricbutareactuallyindecentpseudoscience.Suchmarketingtechniquestakeadvantageofthevulnerabilitytothreatsandweakercompetenceofpeoplewhocarefortheirskinstronger.

IfCaucasiansmovetoaregionwithstrongsunrays,itisonlynaturalthattheriskofskincancerincreases.However,ifJapaneseorIndiansmovetoanorthernareaofEuropewithweaksunlight,theweakerUVrayscontrarilycan leadtovitaminDdeficiency,anditisevidentthattheriskofricketsinchildrenincreases.IfahealthyJapanesepersonlivinginJapanhasexcessivefearofUVraysandexcessivelyavoidssunrays,thiscanevenbeapotentialcauseof ricketsinchildren.Humanbeingshaveadaptedtotheirhabitatbyadjustingthemelanincontentintheirskin dependingontheUVrays,andafterlongyearsthisresultedinracialskincolordifferences.Thisisaresultofthe peoplelivingineachregionadaptingtotheirnaturalenvironmentalfactorofsunlightasorganismsoveralong period.However,moderntechnologyhasallowedustomovefromtheNorthernHemispheretotheSouthernHemispherewithinaday.Itisevidentthatifthenorthernmidwinterenvironmentsuddenlychangestoamidsummer environmentwithstrongUVrays,ourbodiesareunabletoadapt.

Justasweappreciatethewarmthoffireduringcoldwinters,welongforsunlight.Andlikefire,UVraysarevital toourlivesbutwewillgetburnedifwearetooclose.UVlightisnottheonlyvillain,andknowinghowtokeepsome distancefromtheinconvenientconditionscreatedbymoderncivilizationisvitaltoourlives.“Bewareoffire”does

notdenyfirebutwarnsustohandlewithcare.Wemustunderstandthestandpointofthespeakerandthesituation ofthewordsaspriorinformationinordertojudgeifthescientificinformationisusedasfraudulentrhetoric. Discussionsbetweenexpertscanbebasedonimplicitcommonunderstanding,buttheknowledgebetweenthe consumerswillhaveastrongasymmetry,andevenfromgoodintent,wordsfromexpertscouldleadtounexpected misunderstandingsandactions.Wemustrecognizethatcommunicationhasriskinitself.

Inmodernsocietysciencemayhavebecomeanotherreligion,wherewordsinscientificvocabularyaresometimes trustedwithoutdoubt.Asengineersandscientists,wemustconsciouslyunderstandoursocialresponsibilityand steptowardthelistenersandhelpthemunderstand,andnotparticipatewiththosewhoclaimtobescientific withillintent.Developmentofahealthycosmeticsindustrycanonlybeachievedbyscienceandtechnologythat keepsdistancefrompseudoscientificrhetoricandsupportscorrectmarketing.

1.6.2BindingCorporations,Consumers,andSocietyWithMaternalCommunication

Corporations,consumers,andsociety ifthereisnoinformationgapandequalcommunicationispossible,the communicationbetweenthesethreestakeholderswillbeawin-win-winrelationship.Theovalpatternshownin Fig.1.4 isavisualizationofthebasicsofthisidealeconomicinterchange.Inthismodernworldtherightsoftheconsumersareexpandingbuttheirinformationisstilllimited.Wemustkeepinmindthatthereisaninformationgap betweentheconsumersandcommunicateasifamotherwouldtoherchildwithmaternalcommunication.

Maternalcommunicationcanbeshownbyanegg-shapedpattern.Theinformationilliterateconsumersare shownisasmallcircleandthecorporatesareshowninalargecircle,andthesocietyformsaneggshapeinthebackground.Thisalsoresemblesabirds-eyeviewofamotherholdingherchild(Fig.1.5).Inasocietywithhighly advancedinformationcommunicationtechnology,corporationsmustusematernalcommunicationtoleantoward theconsumersandtalkgentlytomaintainthewin-win-winrelationship.Overcomingtheriskofacommunication gapisalsoademandfromoursocietyandtimes.

Cosmeticsaredistributedamongsocietythroughcorporateeconomicalactivities,butiftheconsumerneedsand scienceandtechnologyofthecorporateseedsarehealthy,theproductswillkeeptheirsalesandthemarketwill continue.Thecosmeticsindustryisafashiontofollowtheclients’changingneeds,andthischangeitselfhasvalue. Thevisionandevaluationofbeautychangestomakeanewcontextintheworldandcontinuestocreatesocialvalue.

1.6.3SoftSciencetoReadtheChangesofTrends

Fashionisnotpossibletoexplaininlogic,butisalifestyleoffeeling,awaytofeelsympathybyconversationfrom thesenses,aworldofnonverbalinstinctlanguages.Thestoryofcolor,thestoryofsmell,andthestoryoftouchall

FIGURE1.4 Win-win-winrelationshipofstakeholders.
FIGURE1.5 Maternalcommunication.

Changesinsocioeconomicenvironmentsandoverallculturalenvironmentalchangesarechangesthatleadto thestrongtrendsinthecosmeticsmarket.High-pricedcosmeticsaresoldashigh-endproductsandareacceptedas luxuries,andthentheyspreadtocreatealargermarket.Usingananalogyofsmallstreamsbecominglargerivers, thismarketspreadfromtoptobottomisknownasthetrickle-downeffectandwasbelievedtobeaprinciplein economics.However,inourcurrentabundantmarket,the changeitselfischanging.High-qualityandaffordable productsarefirstadopted,andasiftheygoupstream,high-pricedproductschangetheirfeatures,showinga bottom-upeffect.Nowadaysitiscommontoseeadultfashioninfluencedbyyoungerfashion.Intheeverchangingcosmeticsmarket,theroleofR&Distobeundercovertoanticipatethemarketchangeinadvance andbeprepared.

Themostimportantaspectofmarketinginadynamicmarketistoknowandnotmissthebesttiming.Thebest timingdoesnotonlymeanthatthelaunchisnotdelayed,butaproductlaunchtooearlycanalsowastethetechnology.Marketingdecisionsmustbemadeinadvanceofthebesttiming,andtheR&Dandmarketingcanhavea headstartandcooperatetomeetthebesttimingonlyifthecorporationisstructuredsoR&Dhastheprototypes testedandready.

Beingreadyistopreparebypredictingthefuture,andhavingenoughtimetoprepareforthefuture.Preparingis toquicklyreadthechangesinthemarketforindicationsandmeetthechanges.Inordertoanswertothemarketing demandsof“now,”theorganization’sstructuremustalwayshaveamindsetofbeingabletosynchronizewiththe projectoftomorrowandthedayafter,andconversationwithfutureprojectsinitiatethecooperationofR&Dand marketing.Scienceandtechnologyisanoperationthatrequiresthemindsetofsoftsciencetoalwaysbeonestep ahead.

Productreleasesarebasedonoperationsofresearch,development,andmanufacturing,andtheyneedsupport fromrelatingtechnologicalfollow-upservices.Technologicalfollow-upservicesareoperationsthatsupportoperationssuchaslegalhandlingofregulationsonsafetyandhealthforqualitycontrol,publicannouncementunitedwith marketing,andcustomercareaftertheproductlaunch.

Productsaredistributedintheeconomicchainaftertheyarelaunched,andcosmetictechnologycontributesto thiseconomicchain.Therearemanyeconomicactivitiespriortolaunchfromproductdevelopmentto manufacturing.Inotherwords,therearenonmaterialcostsforR&D,aswellascostsforpurchasing materialsandequipment.Thesepriorcosts,production costs,andengineeringcostsstronglyinfluencethefinal pricewhentheproductpricesaredesignedtomeetconsumerdemands.R&Disaprocedurepriortomarketing, soitisvitalthatthemarketingpoliciesareutilizedinthisprocedure.Goodproductsdonotalways deserveahighprice.Productscanonlybewidelydistributedinsocietywhentheacceptablecostlimitiswell managed.

Evenifanappropriatepriceisset,marketexpansionwillalwayshavearisk.Thebestwaytohandle suchrisksistothink,try,andimprovebasedonexperiencewhilemovingforwardandexpanding.Assuming thattheultimatetargetofthemarketsizeis100,thefirststepisatrialbasedonamarketsizeof10to testthehypothesis,andafterfindingandsolvingtheproblems,therisksofexpandingshouldbeeliminated inamarketsizeof30toreachtheultimategoal,ariskmanagementstrategyofmarketexpansioncalled1030-100.

Cosmeticsareproductswhereemotionalandmentalvaluehavemoreweightthanscientificfunctionality.The customersarenotjustconsumers,butarecosmeticuserswholovetheprocessandeffectsofusingcosmetics.Cosmeticsareamediumandtoolforsocialcommunication.Wemustbeconsistentwithcustomer-focusedmarketing toputourvaluesincustomersfirst.Fromascientificpointo fview,customer-focusedmarketingiscontinuingto createcustomersatisfaction,makesaleseasierforthecompany,andcontributetodevelopingproductsthatsell themselves.Foodproductshavealreadyreachedastageofcookingandgastronomybeyondhungerandthescienceofnutrition.

Thefutureofthescienceandtechnologyofcosmeticsreliesonknowledgeofunderstandingthingsratherthan objectstoproposeauniquesellingpropositionasnewdifferentiatingcosmetics.IntheUnitedStates,thecampaign bytheindustrygroupCTFA(CosmeticToiletryandFragranceAssociation)andgovernmentalFoodandDrug Administrationof“LookGood,FeelBetter”hasalreadyhelpedcancerpatients.Ihopethenextgenerationof cosmeticengineersandresearchersreadingthisbookwillhaveamindsettounderstandthingsandbegeneralists withaflexiblecorebasedonscience,andembracetheideasofsoftsciencewithasensitiveandrichperspective. Timeismoney.Slowandsteady, Wearetomorrow’spast.Passontodaytotomorrow, Thefutureisthepastinpreparation.Andbeprepared.

References

1.MorrisD. Thenakedape:azoologist’sstudyofthehumananimal.London:JonathanCape;1967.Trans.Hidaka,Toshitaka.Tokyo:KadokawaBunko, 1969.

2.HuizingaJ. HomoLudens;astudyoftheplay-elementinculture.Boston:BeaconPress;1955.Trans.Takahashi,Hideo.Tokyo:ChukoBunko,1973.

3.SchliemannH. LeChineetleJaponautempspresent(ChinaandJapaninthepresentage).1867.Trans.Ishii,Kazuko.Tokyo:KodanshaGakujutu Bunko,1998.

4.KaibaraE.In:IshikawaK,editor. Yojo-kun(Lecturesonhealthpreservation).Tokyo:IwanamiBunko;1713.1961.

5.SayamaH.In:TakahashiM,editor. Miyako-FuzokuKewai-Den(Customsofgroominginthecapital).Tokyo:ToyoBunkoHeibonsha;1813.1982.

6.NozakiF.KeshohinnoRekishi EiseiKaraQOLhe (Thehistoryofcosmetics:fromhygienetoQOL.). YakushiGakkaishi 2013;48-1

7.TakahashiM. KeshoMonogatari.(Storyofcosmetics).Tokyo:YuzankakuShuppan;1997.

8.NozakiF,editor. KeshohinnKogyo120NennNoAyumi(Theevolutionof120yearsofthecosmeticsindustry.).Tokyo:NihonKeshohinKougyo Rengoukai;1995.

9.NozakiF.“CustomerService.”AnatanoIryouhaAnnzennKa? IgoushukaraManabuRiskManagement.(Isyourmedicalsafe?Learningrisk managementfromotherindustries).In: KikikanriKenkyuukai MedicalRiskManagementBunkakai.Tokyo:Nanzan-Do;2011.

FIGURE2.3 TrendsinresearchfieldsofarticlespresentedatIFSCCCongresses.OccurrencerateofKOSMET-controlledterms(SH).

2.4.1AnOverviewofAward-WinningPapers

EversincethefirstIFSCCAwardwasgrantedatthe9thIFSCCCongressinBostonbackin1970,duringthe 46yearsupuntilthemostrecentIFSCCCongressinOrlando,USA(2016),atotalof80papersassummarizedin Table2.1 havebeenpresentedwithanawardfortheiroutstandingcontributiontothecosmeticindustry. Lookingataward-winningpapersbysocietiestowhichthefirstauthorsbelong,themajorityofthemarefrom Japan,France,Germany,andtheUnitedStates,i.e.,majorIFSCCsocietieswithlargememberships(Fig.2.4).

Outofthe80papers,40wereonskinbiology(almostone-half),and19onformulation,constitutingalmosta quarterofthefractionpie.Therestcanbecategorizedintodevelopmentofnewingredients,hair-relatedstudies, andpsychologicalaspectsofcosmetics(Fig.2.5).The40papersonskinbiologyconsistof27basicdermatological papersand13evaluativestudiessuchasskinmeasurement.

2.4.2SkinBiology

Whenthe40papersonskinbiologywerebrokendownintotheorgansthattheyaretargeting,itisapparentas shownin Table2.2 thatavastmajorityof22paperswereontheepidermis.Locatedastheoutermostlayeroftheskin wherecosmeticscomeintodirectcontact,notsurprisingly,theepidermiswasconsideredanaccessibleresearch targetbymanyresearchersoveralongperiodoftime(Fig.2.6).

2.4.2.1MoistureintheStratumCorneum

AnattempttomeasuremoisturecontentintheskinhasbeenreportedattheIFSCCCongressinLondon(Paper no.5:1974, Table2.1),whereitwasrewardedwithan“honorarymention.”Theprincipleofthismethodis“lowfrequencyimpedance,”employedinon-sitetoolstomeasureskinmoistureatshopfronts.Thismethodmakes useofthechangesseenintheelectricresistance(impedance)ofthestratumcorneumonceitcomesintocontact withwater,andhenceoffersameansofmeasuringmoistureinthestratumcorneuminvivo.Priortotheintroductionofthismethod,cosmeticshavebeenmadeavailableforthreefacialskintypes,i.e.,for“oily,”“normal,”and “dry”skin,dependingonthesebumcontentoftheconsumer’sskin,andrecommendedaccordingly.In1984,apaper reportedattheIFSCCCongresssuggestedthefourthtypeofskin,a“hybridskin”thatisdrybutabundantinsebum content,thefindingofwhichwaspossiblethroughmeasuringmoistureinthestratumcorneumviatheimpedance method.Thepaperreceivedanhonorarymentionforthiswork(Paperno.20:1984, Table2.1).

Thereafter,thepresenceof“ceramides”withinthestratumcorneumwasrevealed,makingitclearthatthebarrier functionofthestratumcorneumplayedacrucialroleinmaintaininghealthyskin.Asareferenceforthebarrierfunctionofthestratumcorneum,transepidermalwaterlossthatmeasuresthemoisturetranspiredthroughtheskin, cametobeused.

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