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Clinical Pharmacology During Pregnancy

Clinical Pharmacology During Pregnancy

Second Edition

ClinicalPharmacology DuringPregnancy SecondEdition

UniversityofSouthCarolina, ArnoldSchoolofPublicHealth, Columbia,SC,UnitedStates

RiskSciencesInternational,Ottawa,ON,Canada

SchoolofEpidemiologyandPublicHealth, UniversityofOttawa,Ottawa,ON,Canada

AssociateProfessorofNursing UniversityofSouthCarolina Beaufort,Bluffton SC,UnitedStates

AcademicPressisanimprintofElsevier 125LondonWall,LondonEC2Y5AS,UnitedKingdom 525BStreet,Suite1650,SanDiego,CA92101,UnitedStates 50HampshireStreet,5thFloor,Cambridge,MA02139,UnitedStates TheBoulevard,LangfordLane,Kidlington,OxfordOX51GB,UnitedKingdom

Copyright © 2022ElsevierInc.Allrightsreserved.

Nopartofthispublicationmaybereproducedortransmittedinanyformorbyany means,electronicormechanical,includingphotocopying,recording,oranyinformation storageandretrievalsystem,withoutpermissioninwritingfromthepublisher.Detailson howtoseekpermission,furtherinformationaboutthePublisher’spermissionspolicies andourarrangementswithorganizationssuchastheCopyrightClearanceCenterandthe CopyrightLicensingAgency,canbefoundatourwebsite: www.elsevier.com/permissions .

Thisbookandtheindividualcontributionscontainedinitareprotectedundercopyright bythePublisher(otherthanasmaybenotedherein).

Notices

Knowledgeandbestpracticeinthis fieldareconstantlychanging.Asnewresearchand experiencebroadenourunderstanding,changesinresearchmethods,professional practices,ormedicaltreatmentmaybecomenecessary.

Practitionersandresearchersmustalwaysrelyontheirownexperienceandknowledgein evaluatingandusinganyinformation,methods,compounds,orexperimentsdescribed herein.Inusingsuchinformationormethodstheyshouldbemindfuloftheirownsafety andthesafetyofothers,includingpartiesforwhomtheyhaveaprofessional responsibility.

Tothefullestextentofthelaw,neitherthePublishernortheauthors,contributors,or editors,assumeanyliabilityforanyinjuryand/ordamagetopersonsorpropertyasa matterofproductsliability,negligenceorotherwise,orfromanyuseoroperationofany methods,products,instructions,orideascontainedinthematerialherein.

LibraryofCongressCataloging-in-PublicationData

AcatalogrecordforthisbookisavailablefromtheLibraryofCongress

BritishLibraryCataloguing-in-PublicationData

AcataloguerecordforthisbookisavailablefromtheBritishLibrary

ISBN:978-0-12-818902-3

ForinformationonallAcademicPresspublicationsvisitour websiteat https://www.elsevier.com/books-and-journals

Publisher: AndreGerhardWolff

AcquisitionsEditor: ErinHill-Parks

EditorialProjectManager: TracyI.Tufaga

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CoverDesigner: VictoriaPearson

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Thisbookisdedicatedtoalltheindividualswhohaveaddedto andbenefitfromthecollectiveknowledgeandwisdompresented withinthisbook.Thechapterauthorssharetheirinsightswiththe expressgoalofhelpinghealthcare practitionersandtheirclients makethebestclinicaldecisionswhenitcomestotheuseof medicationsinpregnancy.

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Contributors

MahmoudAbdelwahab

OhioStateUniversity,Columbus,OH,UnitedStates

MahmoudS.Ahmed

DepartmentofObstetrics&Gynecology,UniversityofTexasMedicalBranch, Galveston,TX,UnitedStates

SarahArmstrong

FrimleyParkHospital,Surrey,UnitedKingdom

ChestonM.Berlin,Jr.

DepartmentofPediatrics/DivisionofAcademicGeneralPediatrics,PennState CollegeofMedicine,PennStataeChildren’sHospital,Hershey,PA,UnitedStates

BrookieM.Best

UniversityofCalifornia,SkaggsSchoolofPharmacyandPharmaceutical Sciences,SanDiego,CA,UnitedStates

CarolynBottone-Post

UniversityofNorthernColorado,Greeley,CO,UnitedStates

ShannonM.Clark

DepartmentofObGyn,DivisionofMaternal-FetalMedicine,UniversityofTexas MedicalBranch-Galveston,Galveston,TX,UnitedStates

MagedM.Costantine

OhioStateUniversity,Columbus,OH,UnitedStates

KalaR.Crobarger

TannerHealthSystemSchoolofNursing,UniversityofWestGeorgia,Carrollton, GA,UnitedStates

CaraD.Dolin

DepartmentofObstetricsandGynecology,UniversityofPennsylvania,Perelman SchoolofMedicine,Philadelphia,PA,UnitedStates

JeffreyW.Fisher

DivisionofBiochemicalToxicology,NationalCenterforToxicologicalResearch, FoodandDrugAdministration,Jefferson,AR,UnitedStates;ScitoVation,LLC, Durham,NC,UnitedStates

DavidA.Flockhart

IndianaUniversitySchoolofMedicine,Indianapolis,IN,UnitedStates

JeffreyS.Fouche-Camargo

SchoolofHealthSciences,GeorgiaGwinnettCollege,Lawrenceville,GA,United States

WilliamD.Fraser

DepartmentofObstetricsandGynecology,Universite ´ deSherbrooke, Sherbrooke,QC,Canada

JenniferL.Grasch

IndianaUniversitySchoolofMedicine,Indianapolis,IN,UnitedStates

DavidM.Haas

IndianaUniversitySchoolofMedicine,Indianapolis,IN,UnitedStates

Lee-AnnHalbert

UniversityofSouthCarolinaBeaufort,Bluffton,SC,UnitedStates

IsabelleHardy

DepartmentofObstetricsandGynecology,Universite ´ deSherbrooke, Sherbrooke,QC,Canada

CarmenV.Harrison

SchoolofNursing,SimmonsUniversity,Boston,MA,UnitedStates

MaryF.Hebert

DepartmentsofPharmacyandObstetrics&Gynecology,Universityof Washington,Seattle,WA,UnitedStates

HenryM.Hess

EmeritusProfessorofObstetricsandGynecology,UniversityofRochesterSchool ofMedicine,Rochester,NY

JanelleKomorowski

DepartmentofNurse-midwifery,FrontierNursingUniversity,Versailles,KY, UnitedStates

MiaoLi

DivisionofBiochemicalToxicology,NationalCenterforToxicologicalResearch, FoodandDrugAdministration,Jefferson,AR,UnitedStates

MeganLutz

UniversityofWisconsinSchoolofMedicineandPublicHealth,Departmentof Medicine,Madison,WI,UnitedStates

DonaldR.Mattison

UniversityofSouthCarolina,ArnoldSchoolofPublicHealth,Columbia,SC, UnitedStates;RiskSciencesInternational,Ottawa,ON,Canada;Schoolof EpidemiologyandPublicHealth,UniversityofOttawa,Ottawa,ON,Canada

DarshanMehta

DivisionofBiochemicalToxicology,NationalCenterforToxicologicalResearch, FoodandDrugAdministration,Jefferson,AR,UnitedStates

JeremiahD.Momper

UniversityofCalifornia,SkaggsSchoolofPharmacyandPharmaceutical Sciences,SanDiego,CA,UnitedStates

LuisA.Monsivais

DepartmentofObGyn,DivisionofMaternal-FetalMedicine,UniversityofTexas MedicalBranch-Galveston,Galveston,TX,UnitedStates

JenniferA.Namazy

ScrippsClinic,SanDiego,CA,UnitedStates

LuisPacheco

UniversityofTexasMedicalBranch,Galveston,TX,UnitedStates

MariaP.Ramirez-Cruz

DepartmentofObstetricsandGynecology,UniversityofNewMexicoSchoolof Medicine,Albuquerque,NM,UnitedStates

WilliamF.Rayburn

ObstetricsandGynecology,UniversityofNewMexicoSchoolofMedicine, Albuquerque,NM,UnitedStates

MichaelD.Reed

ProfessorEmeritusofPediatrics,DepartmentofPediatrics,SchoolofMedicine, CaseWesternReserveUniversity,Cleveland,UnitedStates

SharonE.Robertson

DepartmentofObstetricsandGynecology,IndianaUniversitySchoolof Medicine,Indianapolis,IN,UnitedStates

ErikRytting

DepartmentofObstetrics&Gynecology,UniversityofTexasMedicalBranch, Galveston,TX,UnitedStates

RachelRyu

DepartmentofPharmacy,UniversityofWashington,Seattle,WA,UnitedStates

SumonaSaha

UniversityofWisconsinSchoolofMedicineandPublicHealth,Departmentof Medicine,Madison,WI,UnitedStates

MichaelSchatz

KaiserPermanente,SanDiego,CA,UnitedStates

JeanneM.Schilder

DepartmentofObstetricsandGynecology,IndianaUniversitySchoolof Medicine,Indianapolis,IN,UnitedStates

StevenA.Seifert

DepartmentofEmergencyMedicine,UniversityofNewMexicoSchoolof Medicine,Albuquerque,NM,UnitedStates;Medical,NewMexicoPoisonand DrugInformationCenter,ClinicalToxicology,Albuquerque,NM,UnitedStates

HarrySoljak

FrimleyParkHospital,Surrey,UnitedKingdom

KimberlyK.Trout

DepartmentofFamilyandCommunityHealth,UniversityofPennsylvania,School ofNursing,Philadelphia,PA,UnitedStates

JenniferWaltz

SchoolofMedicine,UniversityofTexasMedicalBranch,Galveston,TX,United States

XiaoxiaYang

DivisionofInfectiousDiseasePharmacology,CenterforDrugEvaluationand Research,FoodandDrugAdministration,SilverSpring,MD,UnitedStates

AndrewYoumans

UniversityofMichiganSchoolofNursing,MI,UnitedStates

Acknowledgment

Althougheachchapterauthorisacknowledgedbyhavinghis/her/theirname associatedwiththechapters,thetimingofthisbooknecessitatesanadditionalthank youtoeachauthor.Researchandwritingforthisbookstartedbeforeanyonewas awarethatapandemicwouldchangetheworldandraiseconcernsabouttherapeutic interventionsduringpregnancy.

Astheauthorsbecameinvolvedwiththechallengesofworkinginhealthcare,a worldturnedupsidedown longhoursinuncertaintimes,isolation,tryingto understandandpredicttheimpactofcoronavirusonpregnancy,shortagesof equipmentandstaff,andcountlessothertrialsofthetimes theauthorscontinued theirresearchandwritingforthesechapters.

Undernormaltimes,completingabookchaptertakesdedicationandcommitment,andduringpandemic,itgoesbeyondmeasure.Forthis,weareappreciative.

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