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Clinical performance of incobotulinumtoxinA
Clinical experience with incobotulinumtoxinA
Conclusion
References
Further reading
7 Basic science
Introduction
Mechanismof action
Myobloc formulation and dosage
Immunogenicity of Myobloc
Clinical studies in aesthetic medicine
Side effects
Conclusion future outlook
References
8 Neuronox® and Innotox®
Introduction
Microbiological, physicochemical, and biochemical profiles of Neuronox®
Innotox®: novel liquid botulinumtoxin type Aproduct
Use of Neuronox® and Innotox® in Asians
Further reading
9 Injectable daxibotulinumtoxinA(RT002)
References
10 Comparison of botulinum toxins
Introduction
Types of botulinumtoxin A
Mechanismof action
Compositional differences
Dosing
Efficacy
Duration of action
Diffusion and field of effect
Safety
Resistance
Conclusion
Further reading
11 Topical daxibotulinumtoxinA(RT001)
The need for topical delivery
Topical daxibotulinumtoxinA
Topical daxibotulinumtoxinAfor lateral canthal lines
Topical daxibotulinumtoxinAfor hyperhidrosis
Topical daxibotulinumtoxinAfor migraine
Further reading
12 Topical botulinum toxin type A
Introduction
Barriers to transdermal permeation
Nanoemulsion delivery systems
Allergan botulinumtoxin type Atopical nanoparticle delivery system
Conclusions
Further reading
13 Reconstitution and dilution
Introduction
Reconstitution diluents
Foam, shaking, and stirring
After reconstitution: storage, use, and sterility
Fresh or frozen? Does it matter?
What concentration is adequate for cosmetic and noncosmetic indication?
Conclusion
Further reading
14 Benzyl alcohol
Introduction
Saline with benzyl alcohol: early evidence of anesthetic efficacy and historical concerns
Saline with benzyl alcohol: RCTs with botulinumtoxin
Saline with benzyl alcohol: use in combination with lidocaine infiltration
Saline with benzyl alcohol: use in comparison with lidocaine infiltration
Safety of saline with benzyl alcohol
Summary of key concepts
Anatomy
Treatment techniques
Technical variations for lower face contour with neuromodulators
References
23 The masseters and their treatment with botulinum toxin
Introduction
History
Anatomy
Raison d’être for botulinuminjection to the masseters
Bruxism
Treatment method
Complications
Conclusion
References
Further reading
24 Darker skin types
Introduction
Racial and ethnic differences in photoaging
Safety and efficacy of botulinumtoxins in darker skin types
Ethnic specific applications of botulinumtoxin
Conclusion
Further reading
25 Combination noninvasive facial aesthetic treatments with botulinum toxin type A
Anatomy related to multiple therapeutic modalities
Combination therapy in the upper face
Brow ptosis
Combination therapy in the lower face
Neocollagenesis
Injectables
Skin tightening
Vascular lesions and pigmentation
Topical agents
Sequence and timing of a multimodal approach
Summary
Body Shaping: Skin Fat Cellulite
Jeffrey Orringer MD, Jeffrey S. Dover MD, FRCPC, FRCP and Murad Alam MD, MSCI
ISBN 978-0323321976
Cosmeceuticals
Third edition
Zoe Diana Draelos MD, Murad Alam MD, MSCI and Jeffrey S. Dover MD, FRCPC, FRCP
ISBN 978-0-323-29869-8
Lasers and Lights
Fourth edition
George Hruza MD and Elizabeth Tanzi MD
ISBN 978-0-323-48006-2
Photodynamic Therapy
Second edition
Mitchel P. Goldman MD
ISBN 978-1-4160-4211-2
Liposuction
C. William Hanke MD, MPH, FACP and Gerhard Sattler MD
ISBN 978-1-4160-2208-4
Scar Revision
Kenneth A Arndt MD
ISBN 978-1-4160-3131-4
Hair Transplantation
Robert S Haber MD and Dowling B Stough MD
ISBN 978-1-4160-3104-8
Blepharoplasty
Ronald L Moy MD and Edgar F Fincher MD
ISBN 978-1-4160-2996-0
For Elsevier
Content Strategist: Belinda Kuhn
Content Development Specialist: Humayra Rahman Khan
Project Manager: Srividhya Vidhyashankar
Design: Miles Hitchen
Illustration Manager: Nichole Beard
List of contributors
The editor(s) acknowledge and offer grateful thanks for the input of all previous editions' contributors, without whom this newedition would not have been possible.
Murad Alam MD, MSCI, Professor of Dermatology, Otolaryngology, and Surgery; Chief, Section of Cutaneous and Aesthetic Surgery, Northwestern University, Chicago, IL, USA
Andrew F. Alexis MD, MPH Chairman, Department of Dermatology, Mount Sinai St. Luke's and Mount Sinai West; Associate Clinical Professor, Icahn School of Medicine at Mount Sinai, NewYork, NY, USA
GeeYoung Bae MD, Director of Rose Clinic, Clinical Professor in the Department of Dermatology of Ulsan University, College of Medicine, University of Ulsan, Seoul, Korea
Katie Beleznay MD, FRCPC, FAAD, Clinical Instructor, Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada
Jeanette M. Black MD, Dermatologist, Skin Care and Laser Physicians of Beverly Hills, Los Angeles, CA, USA
Andrew Blitzer MD, DDS, Professor Emeritus of Otolaryngology/Head and Neck Surgery, Columbia University, College of Physicians and Surgeons; Adjunct Professor of Neurology, Icahn School of Medicine at Mt Sinai; Director, NY Center for Voice and Swallowing Disorders; Co-Founder and Director of Research, ADN International, NewYork, NY, USA
Jennifer B. Mancuso MD, Dermatology Resident, Henry Ford Hospital, Detroit, MI, USA
Mitchell F. Brin MD Senior Vice President, Global Drug Development, Chief Scientific Officer, BOTOX®, Allergan, Inc., Irvine, CA; Professor of Neurology, University of California, Irvine, CA, USA
Letícia Cardoso Secco MD, Volunteer Dermatologist, Hospital do Servidor Público Municipal de São Paulo, Brazil
Alastair Carruthers MA, BM, BCh, FRCPC, FRCP(Lon), Clinical Professor, Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada
Jean Carruthers MD, FRCSC, FRC (OPHTH), FASOPRS, Clinical Professor, Department of Ophthalmology and Visual Science, University of British Columbia, Vancouver, BC, Canada
Joel L. Cohen MD Director, AboutSkin Dermatology and DermSurgery, Englewood; Associate Clinical Professor, Department of Dermatology, University of Colorado, Denver, CO, USA
Jeffrey S. Dover MD, FRCPC, FRCP Director, SkinCare Physicians, Chestnut Hill, MA;
Associate Clinical Professor of Dermatology, Yale University School of Medicine;
Adjunct Associate Professor of Dermatology
Brown Medical School, Providence, RI, USA
Steven Fagien MD, FACS, Private Practice, Aesthetic Eyelid Plastic Surgery, Boca Raton, FL, USA
Timothy C. Flynn MD
Clinical Professor, Department of Dermatology, University of North Carolina, Chapel Hill, NC; Medical Director, Cary Skin Center, Cary, NC, USA
Jürgen Frevert PhD, Head of Botulinum Toxin Research, Merz Pharmaceuticals GmbH, Potsdam, Germany
Conor J. Gallagher PhD, Senior Medical Director, Facial Aesthetics, Medical Affairs, Allergan, Plc, Irvine, CA, USA
Dee Anna Glaser MD, Professor and Vice Chairman; Director Cosmetic and Laser Surgery, Department of Dermatology, Saint Louis University School of Medicine, Saint Louis, MO, USA
Richard G. Glogau MD, Clinical Professor of Dermatology, University of California San Francisco, San Francisco, CA, USA
Greg J. Goodman MBBS, FACD, MD, Associate Professor, Monash University; Chief of Surgery, Skin and Cancer Foundation Inc , Carlton, VIC, Australia
Pearl E. Grimes MD, Director, Vitiligo and Pigmentation Institute of Southern California; Clinical Professor, Division of Dermatology, David Geffan School of Medicine, University of California, Los Angeles, CA, USA
Bhushan Hardas MD, MBA, US Head of Research & Development and Vice President, Merz Pharmaceuticals, LLC, Greensboro, NC, USA
Shannon Humphrey MD, FRCPC, FAAD, Clinical Assistant Professor, Director of CME, Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada
Matthias Imhof MD, Dermatologist, Aesthetic Dermatology Department, Medico Palais, Bad Soden, Germany
Derek H. Jones MD, Associate Clinical Professor, Dermatology, David Geffen School of Medicine, University of California, Los Angeles; Dermatologist, Skin Care and Laser Physicians of Beverly Hills, Los Angeles, CA, USA
Dr. Michael Z. Lerner, Assistant Professor of Otolaryngology, Albert Einstein College of Medicine, Bronx, NY, USA
Austin Liu MD, Dermatology & Mohs Surgery Center, Doylestown and Sellersville, PA, USA
Ian A. Maher MD, FAAD, Assistant Professor, Department of Dermatology, Saint Louis University, St Louis, MO, USA
Kavita Mariwalla MD, Assistant Clinical Professor, Department of Dermatology, Columbia University, NewYork, NY, USA
Adam R. Mattox DO, MS, Physician Research Fellow, Department of Dermatology, Saint Louis University School of Medicine, Saint Louis, MO, USA
Gary D. Monheit MD, FAAD, FACS, Private Practice, Total Skin and Beauty Dermatology Center, PC; Associate Clinical Professor, Departments of Dermatology and Ophthalmology, University of Alabama at Birmingham, Birmingham, AL, USA
Jasmine O. Obioha MD, Resident, Department of Dermatology, Icahn School of Medicine at Mount Sinai, NewYork, NY, USA
David M. Ozog MD, FAAD, Director of Cosmetic Dermatology; Vice-Chair of Operations, Division of Mohs and Dermatological Surgery, Henry Ford Hospital, Detroit, MI, USA
Amit A. Patel MD, Otolaryngologist, ENT Allergy Group, Shrewsbury, NJ, USA
Andrew Pickett BSc, PhD
Director and Founder, Toxin Research Limited, Wrexham, UK; Adjunct Professor, Botulinum Research Center, UMASS Dartmouth, MA, USA
Roman G. Rubio MD, MBA, Senior Vice President of Clinical Development, Revance Therapeutics, Inc., Newark, CA, USA
Thomas E. Rohrer MD
Clinical Associate Professor of Dermatology, The Warren Alpert Medical School of Brown University, Providence, RI; Director of Mohs Fellowship, SkinCare Physicians, Chestnut Hill, MA, USA
Neil S. Sadick MD, FAAD, FAACS, FACP, FACPh, Clinical Professor, Weill Cornell Medical College, Cornell University; Sadick Dermatology and Research Group, NewYork, NY, USA
Nazanin Saedi, Director, Laser Surgery and Cosmetic Dermatology, Thomas Jefferson University Hospitals, Philadelphia, PA, USA
Gerhard Sattler MD, Fellowof Dermatology; Clinical Director of Rosenparkklinik, Darmstadt, Germany
Kyle Koo-II Seo MD, PhD, Clinical Associate Professor, Dermatology, Seoul National University College of Medicine; Director, Dermatology, Modelo Clinic, Seoul, Korea
Kevin C. Smith MD, FRCPC [Derm], Private Practice, Niagara Falls, ON, Canada
Nowell Solish MD, FRCPC, Assistant Professor of Dermatology, University of Toronto, ON, Canada
Ada R. Trindade de Almeida MD, Dermatologist, Dermatologic Clinic, Hospital do Servidor Público Municipal de São Paulo and private office, São Paulo, Brazil
Jacob M Waugh MD, Illustris Pharmaceuticals, Inc , Palo Alto, CA, USA
Mara Weinstein Velez MD, Dermatologist, SkinCare Physicians of Chestnut Hill, Chestnut Hill, MA, USA
Naissan O. Wesley MD
Clinical Instructor, Medicine, Division of Dermatology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Dermatologist and Dermatologic Surgeon, Skin Care and Laser Physicians of Beverly Hills, Los Angeles, CA, USA
