Table of Contents
Cover image
Title page
Copyright
List of contributors
Preface
Chapter 1. The aging: introduction, theories, principles, and future prospective
Abstract
1.1 Introduction
1.2 Modern theories of aging in biology
1 3 Principles
1.4 Extrinsic and intrinsic factors on aging
1.5 Future perspective (aging therapies)
1.6 Summary
References
Chapter 2. Impact of aging at cellular and organ level
Abstract
2.1 Introduction
2.2 Multicellular organization: human body
2.3 Changes associated with aging
2.4 Aging in cells
2.5 Aging in tissue and organs
2.6 Models to study aging
2.7 Antiaging therapy/treatment
2.8 Conclusion
Competing interests
Declaration of interest
Financial support
Authors’ contributions
References
Chapter 3. Brief about hallmarks of aging
Graphical abstract
Abstract
3.1 The nine hallmarks of aging
3.2 Conclusions
References
Chapter 4. Overview of various antiaging strategies
Abstract
4.1 Introduction
4.2 Modulation of autophagy for successful aging
4.3 Elimination of senescent cells for successful aging
4.4 Plasma transfusion for successful aging
4.5 Intermittent fasting as a means for successful aging
4.6 Regular exercise for successful aging
4.7 Role of antioxidants for successful aging
4.8 Stem cell therapy for successful aging
4.9 Summary
References
Chapter 5. Elimination of damaged cells-dependent antiaging strategy
Abstract
5.1 Introduction
5.2 Aging-associated disease and physiological changes
5.3 Antiaging strategies
5.4 Hallmarks of aging
5.5 Cellular reprogramming
5.6 Models of premature aging based on cellular reprogramming
5.7 Cellular rejuvenation by partial reprogramming
5.8 Implications for regenerative medicine: successes and limitations of in vivo reprogramming
5 9 Conclusion
Acknowledgments
References
Chapter 6. Telomerase reactivation for anti-aging
Abstract
6.1 Introduction
6.2 Aging
6.3 Aging—a telomere–mitochondria relation
6.4 Telomerase and its possible role in antiaging therapies
6.5 Tapping the potential of telomerase
6.6 Stem cells and aging
6.7 Future aspects in antiaging
Acknowledgments
Competing interests
Funding
Authors’ contribution
References
Chapter 7. Epigenetic drugs based on antiaging approach: an overview
Abstract
7.1 Introduction
7.2 The first wave of epigenetic drugs
7.3 The second wave of epigenetic drugs
7.4 The third wave of epigenetic drugs
7.5 The fourth wave of epigenetic drugs
7.6 Conclusion
References
Chapter 8. Exploring the role of protein quality control in aging and age-associated neurodegenerative diseases
Abstract
8.1 Proteins misfolding in aging and diseases
8.2 Protein quality control
8.3 Altered protein quality control in aging and diseases: lessons learned from in vitro and in vivo models
8 4 Therapeutic perspectives
8.5 Emerging techniques
8.6 Conclusion
Acknowledgments
Conflict of interest
Author’s contributions
References
Chapter 9. Dietary restriction and mTOR and IIS inhibition: the potential to antiaging drug approach
Abstract
9.1 Introduction
9.2 The antiaging drug discovery
9 3 The mechanism of pharmacological strategies in antiaging process
9.4 Conclusion
References
Chapter 10. Antiaging drugs, candidates, and food supplements: the journey so far
Abstract
10.1 Introduction
10.2 Antiaging drugs
10.3 Aging molecular and biochemical significance
10.4 Summary
References
Chapter 11. Role of AMP-activated protein kinase and sirtuins as antiaging proteins
Abstract
11.1 Introduction
11.2 AMP-activated protein kinase and its functions
11.3 Sirtuins: role of SIRT1
11.4 Correlation between AMP-activated protein kinase and sirtuins
11.5 Effect of AMP-activated protein kinase and sirtuins on calorie restriction and longevity
11.6 Role of AMP-activated protein kinase and sirtuins in mitochondrial homeostasis
11.7 AMP-activated protein kinase and sirtuins in ageassociated neurodegenerative diseases
11.8 Modulation of AMP-activated protein kinase and sirtuins
11.9 Conclusion
Acknowledgments
Conflict of interest
Author’s contributions
References
Chapter 12. Mitophagy and mitohormetics: promising antiaging strategy
Abstract
12.1 Mitochondrial basis of aging
12.2 Age-associated changes in mitochondria
12.3 UPRmt and mitochondrial hormesis (mitohormesis)
12.4 Pathways involved in mitohormetic response
12.5 Mitohormetic pathways converge on the mitophagy
12.6 Antiaging strategies based on regulation of mitohormesis
12.7 Conclusion
References
Chapter 13. Clearance of senescent cells: potent anti-aging approach
Abstract
13.1 Introduction
13.2 SASP modulators
13.3 Immunotherapeutics
13.4 Senolytics
13.5 Senolytic clinical trials
13.6 Senescence reversal
13.7 Conclusion
References
Chapter 14. Stem cell-based therapy as an antiaging prospective
Abstract
14.1 Introduction
14.2 Classification of stem cells
14.3 Stem cell therapy
14.4 Mechanisms of stem cell therapy in age-related diseases and antiaging
14.5 Molecular mechanism of stem cell therapy from an antiaging perspective
14.6 Limitations of the stem cell therapies
References
Chapter 15. Antiinflammatory therapy as a game-changer toward antiaging
Abstract
15.1 Introduction
15.2 Characteristics of aging
15.3 Theories of aging
15.4 The free radical, oxidative, and mitochondrial theories of aging
15 5 The immune system as a homeostatic system
15.6 Oxidation and inflammation as related homeostatic mechanisms of the immune response
15.7 Conclusion and future perspectives
Conflict of interest
References
Chapter 16. Invertebrate model organisms for aging research
Abstract
16.1 Introduction
16 2 Invertebrate models for aging research
16.3 Caenorhabditis elegans model for aging research
16.4 Drosophila model for aging research
16 5 Drosophila melanogaster and Caenorhabditis elegans for aging research: similarities and contrasts
Acknowledgments
References Index
Copyright
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List of contributors
Raghu Ram Achar, Division of Biochemistry, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India
Faiyaz Ahmad, Department of Zoology, Langat Singh College, Baba Saheb Bhim Rao Ambedkar Bihar University, Muzaffarpur, Bihar, India
Vyshnavy Balendra
Saint James School of Medicine, Park Ridge, IL, United States
Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Kanthesh M. Basalingappa, Division of Molecular Biology, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India
Bedanta Bha acharjee, Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India
Hareram Birla
Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, U ar Pradesh, India
Department of Anesthesiology, New Jersey Medical School, Rutgers University, Newark, NJ, United States
S. Chandan, Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India
Anuradha Venkatakrishnan Chimata, Department of Biology, University of Dayton, Dayton, OH, United States
Debabrata Dash, Biochemistry Laboratory, Department of Zoology, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, India
Alex Deamer, Independent Scholar, London, United Kingdom
Bhargab Deka, Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India
Gouri Deshpande
Department of Physics, Karnatak University, Dharwad, Karnataka, India
PG Department of Physics, JSS College of Arts, Commerce, & Science, Mysuru, Karnataka, India
Prajakta Deshpande, Department of Biology, University of Dayton, Dayton, OH, United States
Vinodinee Dubey, Biochemistry Laboratory, Department of Zoology, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, India
Namrata Dwivedi, Biotechnology Centre, Jawaharlal Nehru Krishi Vishwa Vidyalaya, Jabalpur, Madhya Pradesh, India
Josephine Esposto, Department of Environmental and Life Sciences, Trent University, Peterborough, ON, Canada
Jacques Ferreira, Independent Scholar, London, United Kingdom
Edward Giniger, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, United States
Neha Gogia, Department of Genetics, Yale School of Medicine, New Haven, CT, United States
T.S. Gopenath, Department of Biotechnology and Bioinformatics, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India
Nidhi Gupta, Biochemistry Laboratory, Department of Zoology, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, India
Fatema Haidery, Yale College, Yale University, New Haven, CT, United States
G. Harini, Department of Food Science & Nutrition, Yuvaraja’s College (Autonomous), University of Mysore, Mysore, Karnataka, India
Raj Kumar Koiri, Biochemistry Laboratory, Department of Zoology, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, India
Dhiraj Kumar, Department of Zoology, Rameshwar College, Baba Saheb Bhim Rao Ambedkar Bihar University, Muzaffarpur, Bihar, India
Janghoo Lim
Department of Genetics, Yale School of Medicine, New Haven, CT, United States
Interdepartmental Neuroscience Program, Yale University, New Haven, CT, United States
Department of Neuroscience, Yale School of Medicine, New Haven, CT, United States
Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale School of Medicine, New Haven, CT, United States
Chih-Li Lin, Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
Kimberly Lu ik
Interdepartmental Neuroscience Program, Yale University, New Haven, CT, United States
Department of Neuroscience, Yale School of Medicine, New Haven, CT, United States
Tarun Minocha, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, U ar Pradesh, India
Anamika Misra, Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U ar Pradesh, India
Rayees Ahmad Naik, Biochemistry Laboratory, Department of Zoology, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, India
Barsha Baisakhi Nayak, Division of Infectious Disease Biology, Institute of Life Science, Bhubaneswar, Odisha, India
Victor Olmos, Department of Genetics, Yale School of Medicine, New Haven, CT, United States
Chetan Panda, Department of Agricultural Biotechnology, College of Agriculture, Odisha University of Agriculture and Technology, Bhubaneswar, Odisha, India
Roshni Rajpoot, Biochemistry Laboratory, Department of Zoology, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, India
Manjula Ramu, Department of Pharmacology, Yale School of Medicine, New Haven, CT, United States
Andrew Sco , National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, United States
Shabnam Shabir, School of Bioengineering and Biosciences, Phagwara, Punjab, India
Anshul Shakya, Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India
Naveen Shivavedi, Shri Ram Group of Institutions, Faculty of Pharmacy, Jabalpur, Madhya Pradesh, India
Shreya Shreshtha, Division of Molecular Biology, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India
Arvind Kumar Shukla, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, United States
Aditi Singh, Department of Biology, University of Dayton, Dayton, OH, United States
Amit Singh
Department of Biology, University of Dayton, Dayton, OH, United States
Premedical Program, University of Dayton, Dayton, OH, United States
Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH, United States
The Integrative Science and Engineering Center, University of Dayton, Dayton, OH, United States
Center for Genomic Advocacy (TCGA), Indiana State University, Terre Haute, IN, United States
Mahendra P. Singh, School of Bioengineering and Biosciences, Phagwara, Punjab, India
Sandeep Kumar Singh, Sanjay Gandhi Institute of Medical Sciences, Lucknow, U ar Pradesh, India
K.C. Sumukha, Division of Biochemistry, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India
Rithwick Surya, Division of Biochemistry, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India
Leon Tejwani
Interdepartmental Neuroscience Program, Yale University, New Haven, CT, United States
Department of Neuroscience, Yale School of Medicine, New Haven, CT, United States
Sing-Hua Tsou, Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan
Sonali S. Vishal, Department of Pathology, Yale School of Medicine, New Haven, CT, United States
Sanjeev Kumar Yadav, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, U ar Pradesh, India
J.R. Yodhaanjali, Division of Biochemistry, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India
Sumaira Yousuf, School of Bioengineering and Biosciences, Phagwara, Punjab, India
