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Bioquímica médica

QUINTA EDICIÓN

John W. Baynes, PhD

Carolina Distinguished Professor Emeritus

Department of Pharmacology, Physiology and Neuroscience

University of South Carolina School of Medicine

Columbia, SC, USA

Marek H. Dominiczak, MD, Dr Hab Med, FRCPath, FRCP (Glas)

Hon Professor of Clinical Biochemistry and Medical Humanities

College of Medical, Veterinary and Life Sciences

University of Glasgow

Glasgow, Scotland, UK

Docent in Laboratory Medicine

University of Turku

Turku, Finland

Consultant Biochemist

Clinical Biochemistry Service

National Health Service (NHS) Greater Glasgow and Clyde Gartnavel General Hospital

Glasgow, Scotland, UK

Índice de capítulos

Instrucciones para el acceso en línea

Cubierta

Portada

Página de créditos

Colaboradores

Agradecimientos

Dedicatoria

Prefacio

Abreviaturas

Sección 1: Introducción

Capítulo 1: Introducción

Resumen

Bioquímica y la práctica de la medicina: introducción y visión general

Abreviaturas

Sección 2: Moléculas y células

Capítulo 2: Aminoácidos y proteínas

Resumen

Introducción

Aminoácidos

Amortiguadores o tampones

Péptidos y proteínas

Purificación y caracterización de las proteínas

Análisis de la estructura proteica

Resumen

Abreviaturas

Capítulo 3: Hidratos de carbono y lípidos

Resumen

Introducción

Hidratos de carbono

Lípidos

Estructura de las membranas biológicas

Resumen

Abreviaturas

Capítulo 4: Membranas y transporte

Resumen

Introducción

Tipos de procesos de transporte

Resumen

Abreviaturas

Sección 3: Metabolismo

Capítulo 5: Transporte de oxígeno

Resumen

Introducción

Características de las proteínas globinas de los mamíferos

Modulación alostérica de la afinidad de la hemoglobina por el oxígeno

Temas seleccionados

Resumen

Abreviaturas

Capítulo 6: Proteínas catalíticas: enzimas

Resumen

Introducción

Reacciones enzimáticas

Cinética enzimática

Mecanismo de acción enzimática

Inhibición enzimática

Regulación de la actividad enzimática

Medición enzimática de la glucosa sanguínea

Resumen

Abreviaturas

Capítulo 7: Vitaminas y minerales

Resumen

Introducción

Vitaminas liposolubles

Vitaminas hidrosolubles

Suplementos vitamínicos en la dieta

Minerales

Resumen

Abreviaturas

Capítulo 8: Bioenergética y metabolismo oxidativo

Resumen

Introducción

Oxidación como fuente de energía

Energía libre

Conservación de la energía por acoplamiento de reacciones con la hidrólisis de ATP

Síntesis mitocondrial de adenosina trifosfato a partir de coenzimas reducidas

El sistema de transporte de electrones mitocondrial

Transferencia de electrones de NADH a las mitocondrias

Síntesis de adenosina trifosfato: hipótesis quimiosmótica

Inhibidores del metabolismo oxidativo

Regulación de la fosforilación oxidativa

Resumen

Abreviaturas

Capítulo 9: Metabolismo anaerobio de los hidratos de carbono en el eritrocito

Resumen

Introducción

Eritrocito

Glucólisis

Síntesis de 2,3-bisfosfoglicerato

Vía de las pentosas fosfato

Resumen

Abreviaturas

Capítulo 10: Ciclo de los ácidos tricarboxílicos

Resumen

Introducción

Funciones del ciclo de los ácidos tricarboxílicos

Piruvato carboxilasa

Complejo piruvato deshidrogenasa

Enzimas y reacciones del ciclo de los ácidos tricarboxílicos

Rendimiento energético del ciclo de los ácidos tricarboxílicos

Reacciones anapleróticas («de relleno»)

Regulación del ciclo de los ácidos tricarboxílicos

Resumen

Abreviaturas

Capítulo 11: Metabolismo oxidativo de los lípidos en el hígado y el músculo

Resumen

Introducción

Activación de los ácidos grasos para el transporte al interior de las mitocondrias

Oxidación de los ácidos grasos

Cetogénesis, una vía metabólica singular del hígado

Resumen

Abreviaturas

Capítulo 12: Biosíntesis y almacenamiento de hidratos de carbono en el hígado y el músculo

Resumen

Introducción

Estructura del glucógeno

Glucogénesis hepática a partir de la glucosa sanguínea

Vía de la glucogenólisis hepática

Regulación hormonal de la glucogenólisis hepática

Mecanismo de acción del glucagón

Movilización del glucógeno hepático por la adrenalina

Glucogenólisis muscular

Regulación de la glucogénesis

Gluconeogénesis

Resumen

Abreviaturas

Capítulo 13: Biosíntesis y almacenamiento de ácidos grasos

Resumen

Introducción

Síntesis de ácidos grasos

Almacenamiento y transporte de ácidos grasos: síntesis de triacilgliceroles (triglicéridos)

Regulación de los depósitos de grasa corporal total

Resumen

Abreviaturas

Capítulo 14: Biosíntesis del colesterol y de los esteroides

Resumen

Introducción

Estructura de la molécula de colesterol

El colesterol se encuentra esterificado en el interior celular y en el plasma

Biosíntesis del colesterol

Eliminación del colesterol: ácidos biliares

Hormonas esteroideas

Vitamina D

Resumen

Abreviaturas

Capítulo 15: Biosíntesis y degradación de los aminoácidos

Resumen

Introducción

Metabolismo de las proteínas de la dieta y endógenas

Degradación de los aminoácidos

Metabolismo del esqueleto carbonado de los aminoácidos

Biosíntesis de los aminoácidos

Enfermedades hereditarias del metabolismo de los aminoácidos

Resumen

Abreviaturas

Capítulo 16: Biosíntesis y degradación de nucleótidos

Resumen

Introducción

Metabolismo de las purinas

Metabolismo de las pirimidinas

Formación de desoxinucleótidos

Resumen

Abreviaturas

Capítulo 17: Hidratos de carbono complejos: glucoproteínas

Resumen

Introducción

Estructuras y enlaces

Interconversiones de los azúcares de la dieta

Otras vías del metabolismo de los nucleótidos azúcar

Biosíntesis de oligosacáridos

Funciones de las cadenas de oligosacáridos de las glucoproteínas

Resumen

Abreviaturas

Capítulo 18: Lípidos complejos

Resumen

Introducción

Síntesis y recambio de los glicerofosfolípidos

Esfingolípidos

Enfermedades de almacenamiento lisosomal secundarias a defectos en la degradación de los glucolípidos

Antígenos de grupo sanguíneo ABO

Resumen

Abreviaturas

Capítulo 19: Matriz extracelular

Resumen

Introducción

Colágenos

Proteínas no colagenosas en la matriz extracelular

Proteoglucanos

Comunicación de las células con la matriz extracelular

Resumen

Abreviaturas

Sección 4: Bases moleculares de la herencia

Capítulo 20: Ácido desoxirribonucleico

Resumen

Introducción

Estructura del ácido desoxirribonucleico

Ciclo celular en las células eucariotas

Replicación del ADN

Reparación del ADN

Tecnología de ADN recombinante

Principios de hibridación molecular

Clonación de ADN

Resumen

Abreviaturas

Capítulo 21: Ácido ribonucleico

Resumen

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Ath p1272 N 28 ’19 200w

Booklist 17:66 N ’20

“This new volume has been produced in an international milieu which is characterized by at least two sets of conditions. The first are those generated by the talk of a league of nations, and the second is the fait accompli of a socialist state in bolshevik Russia. And it is because the author seeks to harmonize his theories with these novel phenomena that his book acquires an importance such as is hardly indicated by the limitations of its title.” B. K. Sarkar

Freeman 1:476 Jl 28 ’20 1200w

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India which contains no word of bitterness, no trace of violent controversy, no exaggeration or over-statement.”

The Times [London] Lit Sup p723 D 11

’19 950w

MACDONALD, JAMES RAMSAY. Parliament and revolution. (New library of social science) *$1.50 Seltzer 335 20–26685

“‘Parliament and revolution’ is a careful comparison between the existing government in England and the aims and projects of the Bolshevists. While the book is antibolshevist, Mr Macdonald is quick to recognize any sound reasoning in the bolshevist theories to denounce the flaws in the rule of Parliament. He includes a description of the working of the soviet system in Russia, and a discussion of ‘direct action,’ the name under which bolshevism is discussed and advocated by the British labor party.” Springf’d Republican

“Not in any sense an objective scientific study, but an assertion of principles that deserves attention.”

Ind 104:247 N 13 ’20 60w

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Nation 110:826 Je 19 ’20 850w

“In a measure, Mr Macdonald’s book is a salutary corrective to a good deal of loose vituperation. But there is another aspect to the matter with which he has failed to deal. Granted the ignorance and inertia of the modern electorate what, at bottom, are its causes?... The trade unions have an importance which Mr Macdonald altogether fails to give them in this study.” H.

New Repub 22:383 My 19 ’20 1800w

“The book is one that, we warrant, will not fully satisfy any single Socialist. One feels himself at times tantalized between enjoyment of some excellent statement of principle or fact or analysis of some particular question, only to draw a conclusion here and there that appears to be a concession to conventional opinion. Yet the book will appeal to all but the romanticists and those of fixed opinions.” James Oneal

N Y Call p10 Jl 25 ’20 1000w

“The first volume of the New library of social science seems to me the most straightforward treatise on government which has come out since the beginning of the war. ” M. H. Anderson

Pub W 97:998 Mr 20 ’20 320w

“It is to be hoped that this contribution may stimulate a further discussion on these important questions of the technique of revolution.”

Socialist R 10:28 Ja ’21 920w

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Springf’d Republican p11a Je 27 ’20 100w

“The whole book is a careful study of dangerous political tendencies of the times and well worth reading by adherents and opponents of socialism alike.” B. L.

Survey 44:417 Je 19 ’20 450w

The Times [London] Lit Sup p615 O 30 ’19 240w

“This is the story of a little girl who visited the land behind the dictionary and found out for herself that words are alive.” Eileen was sitting in the schoolroom writing out the words she had misspelled and trying to remember that syntax doesn’t end in tacks, when the letter X suddenly jumped out of her inkwell and confronted her. Under his guidance she visited Dictionary Town and there met the words who live in English Wordland, “plain strong Anglo-Saxon words, French aristocrat words who came over with William the Conqueror, the old giant Greek and Latin words, foreign words from every land who have been adopted by Mother English Language, and the happy-go-lucky slang words who live in a gipsy camp outside of Dictionary Town.” The whimsical illustrations are by Stuart Hay.

“A very clever little idea, this. With all her fun, the author tries to be soundly etymological, which will please the educators, without annoying the children. The illustrator, Stuart Hay, adds much with his line-drawings to a book which is bound to give its readers a good time.”

Lit D p90 D 4 ’20 270w

“It will be an excellent book for supplementary reading in the elementary grades. The story moves with much briskness and variety.”

N Y Evening Post p14 N 13 ’20 220w

MACDONNELL,

JAMES FRANCIS CARLIN

(FRANCIS CARLIN, pseud.). Cairn of stars. *$1.50 Holt 821

20–9075

A second volume of poems by the author of “My Ireland.” As in the previous volume lyric verse predominates and the themes are drawn from Irish landscape and custom and fairy lore. A few of the titles are: The cairn of stars; A girl’s song; The black swans; The market town; The seventh son; A Munster marriage; An Irish madonna; For a god-child; The queen of Kerry; The coming of the fairies; The herdsman’s son; The beggar’s blessing.

Booklist 16:337 Jl ’20

“There is more pure poetry to the square inch of expression on the printed page of Francis Carlin than there is on the whole leaves of printed pages by any Irish-American poet of today. ‘The cairn of stars’ is far better than the earlier book. In the nearly three years since ‘My Ireland,’ Mr Carlin has added a deliberately finished technique to the instinctive technique that was his original gift. He has learned to manage his metres in a way to bring out all the finer shades of his moods and without impairing the spontaneity of feeling. At the same time he has greatly broadened the scope of his interests.” W. S. B.

Boston Transcript p11 My 22 ’20 1450w

“Very tuneful and pleasurable and wholesome even if the more rare and mysterious promise of certain earlier poems is not entirely fulfilled.”

Cath World 112:397 D ’20 190w

Reviewed by Mark Van Doren

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N Y Times p16 N 7 ’20 490w

MCDOUGALL, WILLIAM. Group mind. *$5

Putnam 301

20–13131

“A sketch of the principles of collective psychology with some attempt to apply them to the interpretation of national life and character.” (Sub-title) The author holds that “ a society, when it enjoys a long life and becomes highly organized, acquires a structure and qualities which are largely independent of the qualities of the individuals who enter into its composition and take part for a brief time in its life.” Thus a collective mental life is not merely the sum of the mental lives of its units but is a “collective mind” or, if one prefers, “ a collective soul.” The book is a sequel to the author’s “Introduction to social psychology” and assumes the reader’s acquaintance with it. The contents fall into three parts: General principles of collective psychology; The national mind and character; The development of national mind and character. There is an index.

“Soundly empirical as his methods are, Mr McDougall may well fail to convince the ardent humanitarian of the error of his ways.... Nevertheless, the problem of a national eugenics must be faced and solved, not simply burked on sentimental grounds. Meanwhile,

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MCDOWALL, ARTHUR SYDNEY. Realism; a study in art and thought. *$4 Dutton 701 (Eng

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20–6732

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Dial 69:208 Ag ’20 290w

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N Y Times 25:18 Jl 4 ’20 200w

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N Y Evening Post p25 O 23 ’20 70w

MCFEE, WILLIAM. Captain Macedoine’s daughter. *$1.90 (2c) Doubleday 20–26979

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Booklist 17:117 D ’20

“A

tale of strange people, strange places, strange motifs, strange morals told with brilliant effect and satisfying completeness.” S. M.

Bookm 52:370 D ’20 360w

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Bookm 52:367 Ja ’21 90w

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E. F. E.

Boston Transcript p6 N 3 ’20 1200w

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N Y Call p7 Ja 9 ’21 380w

“‘Captain Macedoine’s daughter’ gladdens the heart of the serious lover of English prose, for it proves that in Mr McFee we have no mere casual of the pen, no fortunate adventurer upon ink who triumphed by chance, but a soberly devoted novelist from whom many years of fine work may confidently be expected.”

N Y Evening Post p5 N 13 ’20 1100w

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“Unmistakably a big, compelling, haunting book.” F: T. Cooper Pub. W 98:1190 O 16 ’20 420w

“The outstanding impression is the sense of atmosphere which the narrative imparts to the reader. The narrative has many curious ramifications, but each is an important part of the whole, and the reader will find himself enthralled from the first to the last scene. ”

“Although the author is unusually progressive in having his villain operate with the aid of airplane and machine gun, the general plot and the situations created are such as might be encountered in everyday life and modern crime. An attorney and his wife, on the way to keep an appointment that involves the domestic happiness and honor of both, are found at a lonely spot, the car wrecked, the man dead from a bullet wound, the wife unconscious in the tonneau. Was it another automobile accident, was the man murdered by the wife or did an outsider have a part in the tragedy? These are questions that perplexed the authorities and will perplex and mystify the reader.”

Springf’d Republican

“The basis and material used in the tale is excellent and would make a capital short story.”

Boston Transcript p9 Ja 26 ’21 150w

“A not too lurid mystery interestingly built up and broken down, in a rapid, easy narrative style.”

Ind 104:383 D 11 ’20 20w

“The only marked defect is the author’s attempt to force the reader’s suspicions on characters whose guilt, if ultimately proved by the story, would shock any decent sense of plausibility.”

N Y Evening Post p11 N 27 ’20 70w

“He has written so well, made his people so living and so pleasant, handled his subject so surely, that it is difficult to think of this book as a maiden essay. ”

“Among the better of the new detective tales, ’32 calibre,’ early arouses the interest of the reader and holds it through a series of adventures, with the solution of the mystery not even indicated until the close.”

Springf’d Republican p9a O 31 ’20 150w

MACGILL, PATRICK. Maureen. *$2 (1½c)

McBride

20–13698

Mr MacGill’s new story of Donegal is a mingling of pathos and humor, hard toil and grim poverty, beauty and stark tragedy. Maureen, the daughter of Kathleen O’Malley, tastes all the sorrow and loneliness of an illegitimate child and after her mother’s death leaves the parish. She has won the love of young Cathal Cassidy and he would have her stay, but long before her mother had warned her that her only happiness would lie in marrying a man outside the parish who would not have to suffer for her shame in the eyes of his neighbors, and to spare Cathal this she leaves him. She meets experiences that are bitterly cruel, but after them finds a haven with kind people and at the end of two years returns. Cathal has been faithful and it seems that their love is to bring them happiness, but tragedy overwhelms them. The war and Sinn Fein have a place in the background of the story.

“The characters in general are well drawn, and have that tragic intensity which Synge and others have made us believe to be in the

Celtic blood.”

Ath p1242 N 21 ’19 120w

“Unmitigated truth and sincerity produce a strong reality of characters and atmosphere though not a pleasant story.”

Booklist 17:72 N ’20

“Such a thing to be done at all must be done exceptionally well, and Mr MacGill, with a good style at his command, has achieved a triumph.” G. M. H.

Boston Transcript p6 Ag 7 ’20 520w

“The minor characters are admirably drawn; the chief ones are less vivid and convincing. The weaknesses of the story are glaring: it is poor both in structure and in motivation. Keeran, in the final chapters, is drawn on the lines of Dickens at his worst, and the tragic conclusion brings the reader up with the jolt of an express train coming to a violent halt.”

Cath World 112:547 Ja ’21 220w

“The chief and tragic emphasis falls upon youth, in spite of which the best of the story lies in the penetrating, vivid, and thoroughly human presentation of the old people.” E. P.

“Much of the power of the story lies in the intermingling of quite Russian realism, with an idealism which bursts flamelike through the recital of brutal details. ‘Decent’ is the salutation of the people of Dungarrow for the strangers they meet, and decent is the epithet uppermost in the mind of the reader, in spite of Mr MacGill’s frank exposure of the vices of his own people.” E. L.

Grinnell R 15:283 N ’20 240w

“‘Maureen’ is the story of a peasant girl in Donegal, a terrible story in many ways and a curiously fascinating one. Mr MacGill knows how to flash a scene so vividly before your mind that it haunts your visual memory for days afterward.”

Ind 104:242 N 13 ’20 120w

“In ‘Maureen’ there is considerable alloy, yet much good metal and some precious. But the whole thing needs fusing.” J. C. L.

New Repub 23:261 Jl 28 ’20 400w

“‘Maureen’ is not up to ‘Children of the dead end’ or ‘Rat pit,’ but it is well worth reading, especially to Irish folk and the legion that love the Irish.” S. C. Daljord

N Y Call p11 Ag 1 ’20 600w

“There are very few figures in the story that evoke admiration; most of them, to be quite frank, suggest the opposite. But their vitality is amazing, and because of this authentic possession of the power to make his characters live and breathe, Mr MacGill takes a

prominent place with those other admirable Irish fictioneers, St John Ervine, Shaw Desmond, James Joyce and James Stephens.”

N Y Times 25:279 My 30 ’20 1150w

Reviewed by H. W. Boynton

Review 2:679 Je 30 ’20 500w

“Mr MacGill’s story is a stern presentation not only of characters, but of racial characteristics and psychology. It is always real and alive. The book unrolls before the reader’s eyes a segment of life from rural Ireland with all the reality of a picture film.”

Springf’d Republican p11a Je 13 ’20

“Nothing farther removed from the individualist English novel could be imagined. It is not that the characters are in any way lacking in individuality. They are creatures of flesh and blood right enough, terrible in their humanity. But it is as social rather than as personal values that they count. There is little joy in Mr MacGill’s book one feels that the sun seldom shines in Donegal—but it has creative richness and the supreme quality of truth.”

20–20216

“Miss McGilvary during the progress of the war was the secretary of the Beirut chapter of the Red cross and hence had unusual opportunities for following the trend of events. The story which she tells, and of which she herself was a part, is of deep interest; how an American printing house was converted into a relief bureau; how American philanthrophy did its part in ameliorating the condition of the unhappy people; how difficulties were thrown in the way by the Turks; culminating presently in the arrest of the entire American mission. She tells in thrilling language of a year of horror, and toward the end, of the collapse of the Central powers, the decline of German prestige, and lastly of the end of Turkey.” Boston Transcript

“Hers is a story very well worth the reading, for it is the story of one who was upon the spot and was a witness of all of which she writes.”

Boston Transcript p4 O 27 ’20 330w

“Her book contains vivid notes on the personalities of Enver, Talaat, and Jemal.”

*$5 Scribner 915.2

(Eng ed 20–9379)

“Dr McGovern spent ten years in the Far East, ‘six of which were devoted to school and college studies in Japan.’ He is, therefore, eminently qualified as an interpreter of Japanese thought and Japanese ideas. He begins with an ethnographical, geographical and historical introduction. Having discussed the early history of the Yamato race, he proceeds to give a summary of the evolution of the country since it was opened up by Commodore Perry’s famous visit. He tells of its constitution and political parties, of its organization and government, of its finances, of its efficient bureaucracy (as compared with the cumbrous British form), its imperial socialism (as he calls the centralization of all economic activity), of its military efficiency (based on German models), of its naval menace, of its industrial and commercial development, its banking system, its agriculture, its foreign trade. The concluding section is a very brief statement of the language and literature, the arts of sculpture, painting, the drama, poetry and religion in its three-fold phase.”

Boston Transcript

+ organization; with a preface by Sir E. Denison Ross.

“His book is distinctly illuminating, although we may complain that too much space is devoted to the dry bones of political and military matters, and not enough to the psychology of the people and its expression in literature and the other arts.”

Ath p528 Ap 16 ’20 100w

“A clear, forceful condensation.”

Booklist 16:342 Jl ’20

“Much of Dr McGovern’s book is the expression of a full knowledge and an open mind. It is perhaps the fairest exposition of the whole field of Japanese thought and accomplishment to be found in the vast number of books which have been written about Japan. Dr McGovern’s style is not noticeable for grace. ” N. H. D.

Boston Transcript p11 My 1 ’20 900w

“To those who wish to gain an insight into the potentialities of this forward pushing nation Dr McGovern’s book offers information that is well worth having.”

Y Times 25:18 Jl 11 ’20 1550w

Times [London] Lit Sup p159 Mr 4 ’20 80w

“We are grateful to Mr McGovern for this book, but we should have been more so if he had facilitated its use as a work of reference by the addition of an index. We should be still more grateful to him, if, instead of going over old ground that is open to anyone, he used his very peculiar qualifications in a field that is altogether unexplored.”

HAROLD. Drums of jeopardy.

20–17960

The heroine of this story is Kitty Conover; it is hard to say whether “Cutty,” war-correspondent and secret service agent, or Johnny TwoHawks, is the hero. They both aspire to be, but as Cutty is handicapped by an extra score or so of years, he is at some disadvantage. The theme of the story is Cutty’s attempt to capture a band of “Reds” and to get possession of the “Drums of jeopardy,” a pair of enormously valuable emeralds. Johnny Two-Hawks comes into it because he is fleeing from this band of “Reds” and at one time possesses the drums of jeopardy. Kitty tries to help them both, rather blindly at first, succeeds in getting herself kidnapped and held for ransom and is finally rescued by both heroes. The leader of the Reds is killed and the end of the story leaves Cutty in possession of the drums of jeopardy. Booklist 17:158 Ja ’21

The man with three names was many things in one, besides his names. He was a novelist, a romantic lover of unusual daring, and a

crusader for justice and right. He wrote a book, that went straight to the hearts of sentimental young girls, over a pseudonym. He loved a millionaire’s daughter under his mother’s maiden name, while he flayed her father for the wrongs he had done to the poor. He was the son of a thief who had died in prison for fraudulent business operations and whose fortune he was devoting to expiatory purposes. He achieved all he set out to do: won fame, won the girl, and helped to make over the girl’s father into a good man, expiated his own father’s sins and restored his family name to new honor.

“On the whole, however, his performances are mildly entertaining.”

Ath p619 N 5 ’20 130w

Booklist 16:172 F ’20

Boston Transcript p6 Mr 31 ’20 480w

“It is a pleasant, readable little story, brightly written and sufficiently rapid in movement.”

N Y Times 25:22 Ja 18 ’20 500w

Pub W 96:1692 D 27 ’19 300w

Springf’d Republican p11a Mr 7 ’20 230w

“Here is the same flowing, almost racy style, which we recall in the ‘Private wire to Washington.’ There is no lack of humour.”

MACHARD, ALFRED. When Tytie came (Popaul et Virginie); tr. by Howard Vincent O’Brien.

il *$1.75 Reilly & Lee

20–17171

A story of child life translated from the French. Popaul, a little boy of ten whose father is at the front, adopts Marie, a Belgian refugee and takes her home to Madame Medard. The two have many adventures, humorous and serious, and a deep devotion develops between them. A blinded soldier tells them the tale of Paul and Virginia and they see the parallel to their own story. Deeply in love they go through a marriage ceremony and regard the affair with great seriousness, accepting Tytie, the American doll, as their child. Popaul, following his father’s death, is adopted by a rich countess who, finally moved by his sorrow, sees that the children cannot be separated and takes Marie to live with her also.

MACKAIN, F. E. Buzzy; the story of a little friend of mine.

il *$1.50

Jacobs

This story for little children relates the adventures of a teddy bear. In the first of them Peggy, Buzzy’s little mistress, takes him out into the snow and sets him up, back to a tree, while she makes a snow man, and then the tea bell rings and she runs away and forgets all about him. But Buzzy, left alone, enters into an interesting conversation with the snow man and makes the acquaintance of a

rabbit who invites him to his home for the night. Buzzy has other adventures, meets a princess and takes an unexpected journey to London in a suit case. There are pictures in color and humorous drawings in black and white by the author.

MACKALL,

LAWTON.

Scrambled eggs. il *$1.25

Stewart & Kidd 817

20–6377

“A diverting tale of barnyard life. Eustace the duck and his wife, who believes in a communal incubator, Martha the hen who believes that the female’s place is on the nest, and her frivolous husband Clarence, who is always finding an attractive new pullet, have various adventures that parody amusingly the complications of present-day life.” Cleveland

Booklist 16:377 Jl ’20

“The skillfully ludicrous is not half plentiful enough in this sad world of printed pages. ‘Scrambled eggs, ’ however, is just that.”

Bookm 52:348 D ’20 40w

Cleveland p85 S ’20 50w

“The satire is amusingly carried out, and the illustrations by Oliver Herford help a great deal.”

N Y Times 25:209 Ap 25 ’20 190w

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