Full download An applied guide to process and plant design 2nd edition sean moran pdf docx

Page 1


https://ebookmass.com/product/an-applied-guide-toprocess-and-plant-design-2nd-edition-sean-moran/

Download more ebook from https://ebookmass.com

More products digital (pdf, epub, mobi) instant download maybe you interests ...

Chemical and Process Plant Commissioning Handbook. A Practical Guide to Plant System and Equipment

Installation and Commissioning 2nd Edition Martin

Killcross

https://ebookmass.com/product/chemical-and-process-plantcommissioning-handbook-a-practical-guide-to-plant-system-andequipment-installation-and-commissioning-2nd-edition-martinkillcross/

Process Equipment and Plant Design: Principles and Practices Subhabrata Ray

https://ebookmass.com/product/process-equipment-and-plant-designprinciples-and-practices-subhabrata-ray/

Moran's Dictionary of Chemical Engineering Practice

Sean Moran

https://ebookmass.com/product/morans-dictionary-of-chemicalengineering-practice-sean-moran/

Research Design and Methods: An Applied Guide for the Scholar-Practitioner (NULL)

https://ebookmass.com/product/research-design-and-methods-anapplied-guide-for-the-scholar-practitioner-null/

Process Control: Modeling, Design, and Simulation 2nd Edition B. Wayne Bequette

https://ebookmass.com/product/process-control-modeling-designand-simulation-2nd-edition-b-wayne-bequette/

Research Methods in Applied Settings: An Integrated Approach to Design and Analysis, Third Edition 3rd Edition, (Ebook PDF)

https://ebookmass.com/product/research-methods-in-appliedsettings-an-integrated-approach-to-design-and-analysis-thirdedition-3rd-edition-ebook-pdf/

A Guide to UX Design and Development: Developer's Journey Through the UX Process 1st Edition Tom Green

https://ebookmass.com/product/a-guide-to-ux-design-anddevelopment-developers-journey-through-the-ux-process-1stedition-tom-green/

A Guide to UX Design and Development : Developer's Journey Through the UX Process 1st Edition Tom Green

https://ebookmass.com/product/a-guide-to-ux-design-anddevelopment-developers-journey-through-the-ux-process-1stedition-tom-green-2/

Process Safety for Engineers : An Introduction 2nd Edition Ccps (Center For Chemical Process Safety)

https://ebookmass.com/product/process-safety-for-engineers-anintroduction-2nd-edition-ccps-center-for-chemical-process-safety/

AnAppliedGuideto ProcessandPlantDesign

SecondEdition

SEÁNMORAN

Elsevier

Radarweg29,POBox211,1000AEAmsterdam,Netherlands

TheBoulevard,LangfordLane,Kidlington,OxfordOX51GB,UnitedKingdom 50HampshireStreet,5thFloor,Cambridge,MA02139,UnitedStates

Copyright©2019ElsevierInc.Allrightsreserved.

Nopartofthispublicationmaybereproducedortransmittedinanyformorbyanymeans,electronicor mechanical,includingphotocopying,recording,oranyinformationstorageandretrievalsystem,without permissioninwritingfromthepublisher.Detailsonhowtoseekpermission,furtherinformationaboutthe Publisher’spermissionspoliciesandourarrangementswithorganizationssuchastheCopyrightClearance CenterandtheCopyrightLicensingAgency,canbefoundatourwebsite: www.elsevier.com/permissions

ThisbookandtheindividualcontributionscontainedinitareprotectedundercopyrightbythePublisher (otherthanasmaybenotedherein).

Notices

Knowledgeandbestpracticeinthisfieldareconstantlychanging.Asnewresearchandexperiencebroaden ourunderstanding,changesinresearchmethods,professionalpractices,ormedicaltreatmentmaybecome necessary.

Practitionersandresearchersmustalwaysrelyontheirownexperienceandknowledgeinevaluatingand usinganyinformation,methods,compounds,orexperimentsdescribedherein.Inusingsuchinformationor methodstheyshouldbemindfuloftheirownsafetyandthesafetyofothers,includingpartiesforwhomthey haveaprofessionalresponsibility.

Tothefullestextentofthelaw,neitherthePublishernortheauthors,contributors,oreditors,assumeany liabilityforanyinjuryand/ordamagetopersonsorpropertyasamatterofproductsliability,negligenceor otherwise,orfromanyuseoroperationofanymethods,products,instructions,orideascontainedinthe materialherein.

BritishLibraryCataloguing-in-PublicationData

AcataloguerecordforthisbookisavailablefromtheBritishLibrary

LibraryofCongressCataloging-in-PublicationData

AcatalogrecordforthisbookisavailablefromtheLibraryofCongress

ISBN:978-0-12-814860-0

ForInformationonallElsevierpublications visitourwebsiteat https://www.elsevier.com/books-and-journals

Publisher: JoeHayton

AcquisitionEditor: KostasKIMarinakis

EditorialProjectManager: SaraPianavilla

ProductionProjectManager: PoulouseJoseph

CoverDesigner: MatthewLimbert

TypesetbyMPSLimited,Chennai,India

Preface

Iamahighlyexperiencedpracticalprofessionalprocessengineerwhohasdesigned, commissioned,andundertakentroubleshootingofmanyprocessplants,andmentored andtrainedmanyotherprofessionalengineersinhowtodothesethings.Ihavealso beenauniversityprofessorwhohastaughtprocessplantdesigntoundergraduatesand postgraduatesforanumberofyears.ThishasrequiredmetoreflectuponwhatI knowaboutthesubject,howIknowit,andhowIcanteachittosomeoneelse.In thisbookIwillassumetheroleoftheexperiencedengineer,whotakesluckygraduate chemicalengineersbythehandintheirfirstjobortwoandshowsthemwhatengineeringisreallyabout.Manyarenotsoluckyastohaveexpertguidance.

(Isay “lucky” becausesomanyengineeringgraduatesnevergettoworkasengineers,andthosewhodomayworkinplaceswheremoreseniorengineersareeither absentorunwillingtohelp.)

IndoingsoIwilltakethefairlyinformaltoneIdowhenundertakingthattaskin person,andmayonoccasionexpressmyfrustrationwiththewaythesubjectistaught inUK(andtothebestofmyknowledgeworldwide)highereducation.Afterall,itis notpossibletodescribehowsomethingmightbeimprovedwithoutacknowledging thatthepresentsituationislessthanperfect.Imayalsoexpresstheoddopinionand, asthisisadistillationofexperienceratherthanascientificpaper,Imaynotnecessarily offerreferencestopeer-reviewedjournalarticlesinsupportoftheseopinions. However(despitetheinformalstyleofwriting),themorecontroversialorprovocative anopinionexpressed,themoreeffortIhaveputintomakingsurethatitisheldby themajorityofprofessionalprocessplantdesigners.Towardthisend,thisbookhas nowbeenreviewed,addedto,andimprovedbyhundredsofprofessionalengineers acrosssectorsandworldwide.Manyoftheideaswhichseemcontroversialinacademic circleshavebeenthesubjectofarticlesIhavewrittenforvariousengineeringpublications,andonsocialmedia,wheretheyhavebeenmetwithconsistentlypositive professionalcomment.Theyhaveveryoftenhoweverbeensubjecttostrongnegative feedbackfromacademics,includingcallstobanthisbookandallegationsthatit constitutedprofessionalmisconductonmyparttoholdandexpresstheseviews,which mightbeconsidered “injurioustoacademics.” Althoughthesecametonothing,I admitInowfearacademiamaybealostcause.Maybeprofessionalengineersshould focusoncorrectingmisunderstandingsandteachingthethingsacademiacannotorwill not,ratherthantryingtopreventthematsource.

Thefoundationofthisbookispractice,nottheory.ThroughoutthetextIwill, however,offerquotationsfromothers,linkstobooksandeven,onoccasion,primary

literature.Theseshouldnotbemisunderstoodasthebasisofmyopinions.Inthecase ofquotations,Iamsimplyquotingpeoplewhoagreewithme.Suggestionsfor FurtherReadingarereferencedtoavoidmyhavingtoreproducethecontentofthese often-weightybooksorreinventthewheel.

Acknowledgments

Iwouldliketothankallofthosewhohavehelpedme,especiallymywife, Annemarie.Herpatientassistanceandsurehandwithlanguagehavebeenessentialin thepreparationofthisbook.

Myfellowengineershavegivengenerouslyoftheirtimeinhelpingmetomake surethatwhatIhavewrittenrepresentsconsensusopinion,mostnotablythistime(in additiontothoseIacknowledgedinthefirstedition):JamesTrevelyan,Graeme Trotter,CharlesSanderson,RahulChavan,RickRhead,MorganRodwell,Tim Highfield,MartinArmstrong,SteveLancaster,DeryckCoetzer,ShoaibWangde, NicolasCapon,StevenWoolley,WarwickBagnall,TitiOliyide,CesarPuma, StephenKirby,PaulRichards,RobertSeitz,JonBrooking,PatKinsella,andJustin Jetmar.

Iamalsogratefultothosewhohavekindlyallowedmetoreproduceimagesand material,includingSophieBrouilletatAMOT,DoosanEnpure,JohnEvansatthe formerOlympicDeliveryAuthority,KerryHarrisatAUMA,TomHuddle,Ernest KochmannatNewsonGale,RazibKhan,MalcolmLedgeratLechler,IanAndrewsat SLRConsulting,EdwardLuckiewicz,FionaMacraeatCrowcon,GlennMillerat Grundfos,RossPhilipsattheEEMUA,KeithPlumb,JenniferReevesatElfab,Henry Sandler,ToshSinghatLutz-Jesco(GB)Ltd.,MikeWainwrightatAscendant,and KirstyWarrenatWRAP.

Introduction

Thedisciplineofchemicalengineeringwasoriginallydevelopedbasedonthe insight,byDavis,thatallprocessindustriesusedsimilarunitoperations,whichcould beunderstoodusingsector-independentanalyticaltools.

Processplantdesignisthepinnacleofchemicalengineeringdesign.Thisbookis aboutprocessplantdesign,acrossthebroaddisciplineofchemicalengineering.Itis especiallyimportanttoavoidconfusionbetweenchemicalengineeringand petrochemicalengineering,asmallandarguablydiminishingsubsetofthediscipline. AlthoughIoftenuseexamplesfromthewaterandenvironmentalsectors because thatismyownareaofspecialism chemicalengineeringdoesofcourseencompass theenergy,foodanddrink,organicandinorganicchemicalmanufacture,andmany othersectors.Thisbookisthereforeintendedtoreflectconsensuspracticeacrossthe entirediscipline.Ihaveensuredthisisthecasebyconsultinghundredsofprocess designers,mostnotablyintheUnitedKingdom,NorthAmerica,andtheMiddleand FarEast,workinginallindustriestoverifythattheapproachessuggestedinthisbook dorepresentcurrentconsensuspractice.

IwrotethisbookoriginallybecauseIthoughtthatChemicalEngineering Educationhadlostitswayandbecometootheoreticalandabstracttoadequatelyserve itspurpose,namelytoprovidethe “academicformationofaCharteredChemical Engineer” astheUK’sIChemEputsitinitscourseaccreditationguidelines.However, aswellasconfirmingcurrentconsensuspractice,mydiscussionswithfellowengineers havealsoconfirmedthatprofessionalengineeringdoesnotseemtohavechangedvery muchoverthelastcoupleofdecades,incontrasttowhatistaughtinuniversities, whichhasdriftedfurtherandfurtherfromprofessionalpracticeduringthesame period.

ThebookisbasedonmaterialIhavedeliveredaspartofthedesigncoursesIhave taughtattheUniversitiesofManchester,NottinghamandChester,whichwerein turnbasedonmycontinuingprofessionalengineeringpracticeandprofessionaltrainingofmyfellowengineers.WhenIwrotethefirsteditionofthisbook,Ihadhoped thatthecontentwouldenableotheracademicstodevelopamorerealisticapproachto teachingprocessplantdesign,butmyexperiencesincepublicationofthefirstedition suggeststhatthisbook,whilstmorerelevantthanevertotheteachingofrealistic processdesign,ismostusefultoundergraduateandpostgraduatestudentsandearly careerprocessplantdesigners.

Thebookisinfiveparts.Firstly,Iexplainwhatprocessplantdesignisandhowit isdoneinbroadterms.Next,Igiveadviceonprofessionalpracticeinthemost importantaspectsofprocessplantdesign,ingeneral,andthenatlowandathigh levels;lastly,Icovermoreadvancedaspectsofdesign.

Itshouldbenotedthatthisisabookabout processplant design,ratherthanwhatis knownnowadaysinmanyresearch-leduniversitiesas “processdesign.” Thereisno suchthingasprocessdesign processeshappeninplants,andplantsarethethings whichengineersdesign.

Ithasbecomeclearinwritingthisbookthatweasaprofessionunhelpfullyusethe samewordstomeandifferentthings.Themeaningofwordsandphrasessuchas ConceptualDesign;HAZOP;FunctionalDesignSpecification;DesignPhilosophy; DesignBasis;ProcessIntensification;ProcessDesign;Optimization;Reproducibility; Repeatability;andPrecisionareparticularlycontestedandvarybetweenindustry sectorsandcountries.Tominimizeconfusion,Ihaveexplainedthesenseinwhich IusethesetermsinthetextatthepointoffirstusingthemandIhavealsoincludeda glossaryattheend.Iamnotclaimingthatmyusageistheonlycorrectone,but Ihaveusedtermsconsistentlyinthebook,andmyusagereflects,tothebestofmy knowledge,themostcommonmeaning.

SeánMoran

Wirksworth,UnitedKingdom 2019

CHAPTER1

Processplantdesign

Introduction

Whilethismaynotbeasobvioustotoday’sstudentsofthesubjectasitshouldbe, chemicalengineeringisakindofengineering,ratherthanabranchofchemistry. Similarly,professionalengineeringdesignpracticehasnexttonothingtodowiththe thingcalledprocessdesigninmanyuniversitychemicalengineeringdepartments.I willcoverthereasonsforthiselsewhere,butfirstlet’sstartbydispellingsomeconfusion,byclearingupwhatengineeringis(andisnot),andwhatdesignisallabout.

Whatisengineering?

Istillfeelgladtoemphasizetheduty,thedefiningcharacteristicofthepurescientist probablytobefoundworkinginuniversities whocommitthemselvesabsolutelytospecialized goals,toseekthepurestmanifestationofanypossiblephenomenonthattheyareinvestigating,tocreatelaboratoriesthatarefarmorecontrolledthanwewouldeverfindinindustry, andtoignoreanyconstraintsimposedby,asitwere,realism.

Furtherdownthescale,peoplewhounderstandandwanttoexploitresultsofbasicscience havetodoagreatdealmoreworktoadaptandselecttheresults,andcombinetheresults fromdifferentsources,toproducesomethingthatisapplicable,useful,andprofitableonan acceptabletimescale.

Engineersarethosepeople “furtherdownthescale” asHoare(theclassicistand philosopher)putsit,althoughIdisagreethatwe “exploittheresultsofbasicscience.” Ourprofessionstandsonotherfoundations,thoughwemayhavebeentaughtsomethingdifferentinuniversity.

Inacademiathereisalmostuniversalconfusionbetweenmathematics,applied mathematics,science,appliedscience,engineeringscience,andengineering.Allowme tounconfuseanyonesoconfusedbeforewegetstarted.

Mathematicsisabranchofphilosophy.Itisahumanconstruction,withnoempiricalfoundation.Itismadeofideas,andhasnothingtodowithreality.Itisonly “true” withinitsownconventions.Thereisnosuchthinginnatureasatruecircle,andeven arithmetic(despiteitsgreatutility)isnotfactuallybased.

https://doi.org/10.1016/B978-0-12-814860-0.00002-1

Appliedmathematicsusesmathematicaltoolstoaddresssomerealproblem.Thisis thewayengineersusemathematics,butmanyengineersuseEnglishtoo.Engineering isnomoreappliedmathematicsthanitisappliedEnglish.

Scienceistheactivityoftryingtounderstandnaturalphenomena.Theactivityis ratherlessdoctrinaireandrigidthanphilosophersofsciencewouldhaveusbelieve, andmaywellnotfollowwhattheycallthescientificmethod,butitisaboutexplainingandperhapspredictingnaturalphenomena.

Appliedscienceistheapplicationofscientificprinciplestonaturalphenomenato solvesomereal-worldproblem.Engineersmightdothis(thoughmostlytheydonot) butthatdoesn’tmakeitengineering.

Engineeringscienceistheapplicationofscientificprinciplestothestudyofengineeringartifacts.Theclassicexampleofthisisthermodynamics,inventedtoexplain thesteamengine,whichwasdevelopedwithoutsupportingscience.

ScienceowesmoretothesteamenginethanthesteamengineowestoScience.

Thisisthekindofsciencewhichengineerstendtoapply.Itistheproductofthe applicationofsciencetothethingsengineersworkwith,artificialconstructionsrather thannature.

Engineeringisacompletelydifferentkindofthingfromallprecedingcategories.It istheprofessionofimaginingandbringingintobeingacompletelynewartifactwhich achievesaspecifiedaimsafely,cost-effectively,androbustly.Itmaymakeuseofmathematicsandscience,butsodoesmedicineifwesubstitutethecongruent “medicalscience ” for “engineeringscience.” Ifengineeringwassimplytheapplicationofthese subjects,wecouldhaveamore-or-lesscommonfirstandsecondyearforbothmedical andengineeringcourses,nevermindthevariousengineeringdisciplines.

Adegreewhichischaracterizedbyresearcher-ledapproachesisanidealpreparation forpostgraduateresearch,butfarlesssoforindustry.Uff(seeFurtherReading)has reportedthatthereis “adisconnectbetweenHigherEducation(HE)providersand industryintermsofcapturingemployers’ requirements,willingnesstosatisfythose requirementsandcompetencetosatisfythem.Thiswasespeciallysoinresearchintensiveuniversitieswhoseacademicsarearmedwithaparticularsetofskills....The viewisexpressedthattoomanyuniversitiesfocusonresearchoutputsasasuccessmeasure,ratherthanontheirprimaryroletoproducethegraduatesthatindustryandthe economyneed.” Asaresult,today’sstudentsconsistentlyreportsurpriseathowlittleof theirjobsafteruniversityarethe “properengineering” theylearnedatuniversity.

Nowthatweareclearaboutwhatengineeringis,letusconsiderwhatdesignis.

Whatisdesign?

Ratherthanbeingsomeexoticprovinceofpolo-neckedprofessionals,theabilityto designisanaturalhumanability.Designersimagineanimprovementonrealityasitis,

wethinkofanumberofwayswemightachievetheimprovement,weselectoneof them,andwetransmitourintentiontothosewhoaretorealizeourplan.Thedocumentswithwhichwetransmitourintentionsare,however,justameanstotheultimateendofdesign theimprovementonrealityitself.

Iwilldiscussinthisbookaratherspecializedversionofthisability,butweshould notlosesightofthefactthatdesignisinessencethesameprocess,whetherweare designingaprocessplant,avacuumcleaner,oraweddingcake.

Designerstakeareal-worldproblemwhichsomeoneiswillingtoexpendresources toresolve.Theyimaginesolutionstothatproblem,chooseoneofthosesolutions basedonsomesetofcriteria,andprovideadescriptionofthesolutiontothecraftsmenwhowillrealizeit.Iftheymissthislaststageandifthedesignisnotrealized, theywillneverknowwhetheritwouldhaveworkedastheyhadhoped.

Alldesignersneedtoconsidertheresourceimplicationsoftheirchoices,thelikelihoodthattheirsolutionwillbefitforthepurposeforwhichitisintended,and whetheritwillbesafeevenifitnotusedexactlyasintended.

Ifengineersbringalittlemorerigortotheirdecision-makingthancakedesigners, itisbecauseanengineer’sdesignchoicescanhavelife-and-deathimplications,and almostalwaysinvolveverylargefinancialcommitments.

Sohowdoesengineeringdesigndifferfromotherkindsofdesign?

Engineeringdesign

Engineeringproblemsareunder-defined,therearemanysolutions,good,badandindifferent. Theartistoarriveatagoodsolution.Thisisacreativeactivity,involvingimagination, intuitionanddeliberatechoice.

Likealldesigners,designengineershavetodreamuppossiblewaystosolve problemsandchoosebetweenthem.Engineersdifferfrom,say,fashiondesignersin thattheyhaveawidervarietyoftoolstohelpthemchoosebetweenoptions.

Likealldesigners,theengineer’spossiblesolutionswillincludeapproachestosimilaroranalogousproblemswhichtheyhaveseentowork.Oneofthereasonswhy beginnersareinferiortoexpertsistheirlackofqualitativeknowledgeofthemany waysinwhichtheirkindofproblemscanbesolvedand,moreimportantstill,those wayswhichhavebeentriedandfoundwanting.

Engineersneedtomakesuretheyareansweringtherightquestion.Forexample,a UKmissileprogramcalled “BlueStreak” wasaclassicengineeringfailurebecausethe problemwasnotcorrectlystated.Itwasdesignedtobealong-rangemissilefor nuclearwarheads,butthemissilehadtobefueledimmediatelybeforelaunchandit took30minutestodothis.Hencethemissilewasuselessfortheintendedpurpose,as itwasnotcapableofsufficientlyrapiddeployment.

OveArup

In ToEngineerisHuman,HenryPetroskidiscussestheimportanceofavoidingfailureinengineeringdesign.Manyofhisexamplesoffailure,however,werecausednot bymisspecification,butbydesignerswhoforgotthatthemodelsusedindesignare onlyapproximations,applicableinafairlynarrowrangeofcircumstances.

BillyVaughnKoengoesstillfurthertowardthetruth,whenhepointsoutthat “all isheuristic.” Evenarithmeticisaheuristic.Therearenousefulabsolutetruthsin mathematics,science,orengineering.Thereareonlyapproximations,probabilities, andworkableapproaches.Engineersmayjustbealittleclearerabouttheseissuesthan mathematiciansandscientists,becauseoursolutionsabsolutelyhavetowork.

Projectlifecycle

Thenicheornichesintowhichprocessplantdesignfitsexistinthewiderbackgroundof anengineeringprojectlifecycle.Engineers conceive, design, implement,and operate (CDIO) engineeringsolutions,astheCDIOInitiativeinengineeringeducationpointsout.

Thedetailsofprojectlifecyclesvarybetweenindustries,butthereisacommon core.Take,forexample,thelifecycleforapharmaceuticalproject:

1. Identifytheproblem (astagefrequentlyoverlookedifthereisanassumptionthatthe problemhasalreadybeendefined).Inaddition,problemscanbemis-identified throughfollowingarootcauseanalysisorthroughrelyingontheassumptionsof operatorswhomaynotfullyunderstandtheoperation.

2. Definetheproblem inbusiness,engineering,andscienceterms(startingfrominputs tothedesiredlevelofoutputandproductquality).Notethatforaproblemtobe recognizedbymanagers,itmostlycomesdowntodefiningonhowbusinessis affected.

3. Generateoptions thatprovidepotentialsolutionstotheproblem.

4. Reviewtheoptions againstpredeterminedselectioncriteriaandeliminatethose optionsthatclearlydonotmeettheselectioncriteriaand/orrequisitesafety, health,andenvironmentalstandards.

5. Generatetheconceptualprocessdesign fortheselectedoptions.

6. CommenceFront-EndEngineeringDesign(FEED)studies.Inparallel:

a. Commencedevelopmentworkatlaboratoryscaletoprovidemoredatato refinethebusiness,engineering,andsciencebasisoftheoptions.However, thismaynotbepracticalwherethereisalackofhistoricaldata-e.g.where businessownershiphaschangedduringthelifeofaprocess.

b. CommenceaFEEDstudytoevaluatethepossiblelocations,projecttimescale, andorderofmagnitudeofcost.

c. Developthebusinesscaseatthestrategiclevel.

d. Determineregulatoryrequirementsforproduct/process.

7. Basedontheoutcomesofstep6, reducethenumberofoptions tothosecarriedforwardtothenextlevelofdetail.

8. Commencedetaileddesign.Inparallel:

a. Continuethedevelopmentworkatpilotplantscaleforsettingprocessparametersforoptimaloutputandquality,utilityrequirements(steam,electricity, water,compressedair,etc.)foraunitoutput.

b. Basedinitiallyonthedatafromthelaboratoryandpilotscale,developthe detaileddesignoftheremainingoptionstoallowasanctioncapitalcostestimatetobegeneratedandarefinedprojecttimescale.

c. Continuetodevelopthebusinessscaleleadingtoaprojectsanctionrequestat theappropriatecorporatelevel.

9. Basedontheoutcomesofstep8, selecttheleadoption tobedesignedandinstalled.

10. Inparallel:

a. Continuethedevelopmentworkatthepilotscale.

b. Carryoutthe “designforconstruction” oftheleadoption.A “designfreeze” will almostcertainlyneedtooccurbeforethedevelopmentworkiscomplete.

11. Constructtherequiredinfrastructure,utilities,piping,instrumentation,buildings,etc.,and installtherequiredequipment.

12. Qualify/commissiontheequipment.

13. Commissiontheprocess andverifythattheplantperformsasdesignedandproduces productoftherequiredquality;validatetheprocess.

14. Commenceroutineproduction keepingaclosewatchonqualityconsistencyand output.

15. Improveprocessefficiency basedonqualitativeandquantitativedataandexperience gainedduringroutineproduction.

16. Increasetheplantcapacity makinguseofprocessimprovements,overcomingconstraints,andoptimizationbasedonthedataandexperiencegained;revalidate.

17. Decommissiontheplant attheendoftheprojectlifecycle.

Thepharmaceuticalsectortendstorunmorestagesinparallelthanothersectors butmostofthesestagesexistinallsectors.Theitalicizedtextaboverepresentsthe consensusstagesoftheprocess.

Wheredoesdesignfitintothis?Consultantsmightcallstages1 3aboveplant design.Thosewithabackgroundindesignandbuildcontracting,likeme,usually thinkofdesignasbeingpredominantlywhatthoseinoperatingcompaniescall “ grassrootsdesign,” broadlystages3 10above.Thosewhoworkforoperatingcompanies mightcallstages15and16plantdesign.

Isupposeanargumentcanbemadeforalltheabove,butitshouldbenotedthat beforestep14,verylimiteddesigninformationisavailable.The “designtools” popular inacademiaareusedprofessionallyonlyforstage15/16plantdesign,ratherthanstage 3 10 “grassroots” plantdesignforthisreason.

Another random document with no related content on Scribd:

remain freely available for generations to come. In 2001, the Project Gutenberg Literary Archive Foundation was created to provide a secure and permanent future for Project Gutenberg™ and future generations. To learn more about the Project Gutenberg Literary Archive Foundation and how your efforts and donations can help, see Sections 3 and 4 and the Foundation information page at www.gutenberg.org.

Section 3. Information about the Project Gutenberg Literary Archive Foundation

The Project Gutenberg Literary Archive Foundation is a non-profit 501(c)(3) educational corporation organized under the laws of the state of Mississippi and granted tax exempt status by the Internal Revenue Service. The Foundation’s EIN or federal tax identification number is 64-6221541. Contributions to the Project Gutenberg Literary Archive Foundation are tax deductible to the full extent permitted by U.S. federal laws and your state’s laws.

The Foundation’s business office is located at 809 North 1500 West, Salt Lake City, UT 84116, (801) 596-1887. Email contact links and up to date contact information can be found at the Foundation’s website and official page at www.gutenberg.org/contact

Section 4. Information about Donations to the Project Gutenberg Literary Archive Foundation

Project Gutenberg™ depends upon and cannot survive without widespread public support and donations to carry out its mission of increasing the number of public domain and licensed works that can be freely distributed in machine-readable form accessible by the widest array of equipment including outdated equipment. Many

small donations ($1 to $5,000) are particularly important to maintaining tax exempt status with the IRS.

The Foundation is committed to complying with the laws regulating charities and charitable donations in all 50 states of the United States. Compliance requirements are not uniform and it takes a considerable effort, much paperwork and many fees to meet and keep up with these requirements. We do not solicit donations in locations where we have not received written confirmation of compliance. To SEND DONATIONS or determine the status of compliance for any particular state visit www.gutenberg.org/donate.

While we cannot and do not solicit contributions from states where we have not met the solicitation requirements, we know of no prohibition against accepting unsolicited donations from donors in such states who approach us with offers to donate.

International donations are gratefully accepted, but we cannot make any statements concerning tax treatment of donations received from outside the United States. U.S. laws alone swamp our small staff.

Please check the Project Gutenberg web pages for current donation methods and addresses. Donations are accepted in a number of other ways including checks, online payments and credit card donations. To donate, please visit: www.gutenberg.org/donate.

Section 5. General Information About Project Gutenberg™ electronic works

Professor Michael S. Hart was the originator of the Project Gutenberg™ concept of a library of electronic works that could be freely shared with anyone. For forty years, he produced and distributed Project Gutenberg™ eBooks with only a loose network of volunteer support.

Project Gutenberg™ eBooks are often created from several printed editions, all of which are confirmed as not protected by copyright in the U.S. unless a copyright notice is included. Thus, we do not necessarily keep eBooks in compliance with any particular paper edition.

Most people start at our website which has the main PG search facility: www.gutenberg.org.

This website includes information about Project Gutenberg™, including how to make donations to the Project Gutenberg Literary Archive Foundation, how to help produce our new eBooks, and how to subscribe to our email newsletter to hear about new eBooks.

Turn static files into dynamic content formats.

Create a flipbook
Issuu converts static files into: digital portfolios, online yearbooks, online catalogs, digital photo albums and more. Sign up and create your flipbook.
Full download An applied guide to process and plant design 2nd edition sean moran pdf docx by Education Libraries - Issuu