The right of Clive Page and Simon Pitchford to be identified as authors of this work has been asserted by them in accordance with the Copyright, Designs and Patents Act 1988
No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions
This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).
Notice
Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds or experiments described herein. Because of rapid advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made. To the fullest extent of the law, no responsibility is assumed by Elsevier, authors, editors or contributors for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.
ISBN: 978-0-7020-7818-7
Content Strategist: Alexandra Mortimer
Content Development Specialist: Rae Robertson/Kevin Travers
Publishing Services Manager: Shereen Jameel
Senior Project Manager: Kamatchi Madhavan
Design: Patrick Ferguson
Marketing Manager: Heidi Splane
in China
1 Preface 2
2 Pharmacology, drug names and classification systems 3
3 General principles of drug action 5
4 Molecular aspects of drug action 11
5 Pharmacokinetic and other factors influencing drug action 18
6 Pharmacodynamics and the measurement of drug action 26
7 Drug discovery and the development of small molecules 31
8 Drug discovery and the development of biologicals 34
9 Drug safety, toxicology and pharmacovigilance 39
10 Regulation of drug use 41 11 Outline of transmission and drug action in the nervous system 42
Drugs and the renal system 102
Drugs and the pulmonary system 104
Drugs and the musculoskeletal system 107
Drugs and the gastrointestinal tract 110
Drugs and the genitourinary system 112
Drugs and the skin 113
Drugs and the eye 118
Drugs and the ear 120 26 Drugs used in anaesthesia 123
Drugs and blood: haematopoiesis and haemostasis 80 16 Drugs and the inflammatory and immune response 86
Venoms, toxins, poisons and herbs 153
DALE’S Pharmacology CONDENSED
1 Preface
Pharmacology Condensed has been written as a companion volume to Rang and Dale’s Pharmacology. Each theme has been condensed to a few pages to enable students to retrieve the most pertinent concepts and facts quickly. We consider an understanding of pharmacology is best gained by appreciating the integrative nature of body systems, and thus we have arranged the chapters here to represent this learning context that is nicely represented in further detail in Rang & Dale’s Pharmacology and Integrated Pharmacology by Page et al. As such, chapter headings, and some figures and tables, where pertinent, have been utilized from these textbooks to make their cross-reference obvious and intentional.
We have made some minor changes to this edition to highlight at the front of the book the processes a research team has undertaken to discover and develop a drug. We have also highlighted the safety and toxicology assessment of any new drug, regulatory law, and pharmacovigilance once approved. By doing this we hope the reader understands that pharmacology is a dynamic, live discipline and the application of the principles of pharmacology are requisite to the continued successful introduction of efficacious and safe drugs for use as medicines. This occurs through the continual challenge of predicting drug tolerability via the prism of the therapeutic index. Any research into the number of US Food and Drug Administration (FDA) approvals for novel chemical entities and biologicals over the last 25 years will prove to the reader that this period of drug discovery is as buoyant and exciting as any time preceding it. Biologicals, and specifically antibodies, are a very important and expanding therapeutic consideration and therefore a topic that pharmacologists must embrace so that the characteristics of these molecules can be predicted and assessed
just as small chemical entities are. We have given the subject of antibody discovery and development the same prominence at the front of the textbook (rather than the back) as that of traditional small molecules, especially given the expansion of biologics from inflammatory and autoimmune disorders to cancer therapy and beyond: for example, the current interest in inflammation and neurodegeneration, or the worrying issue of increased antibiotic resistance. A pharmacologist in the twenty-first century therefore needs to understand immunology and antibody design to the same extent that pharmacologists are knowledgeable about physiology and drug actions on the nervous system.
Pharmacology is an applied discipline that has mathematical principles based on the physics of molecular interactions (the HillLangmuir equation) at the core. We encourage readers of this book to remember that whilst pharmacology, as a biological subject, is based on experimentation via scientific method to observe actions, the concepts and predictive qualities are based firmly on logic, and to embrace this will serve to improve understanding of receptor theory (molecular physics), signalling processes (functional selectivity and biased agonism), and modelling of tissue and whole body integrated responses (quorum sensing of cell populations).
As with the previous edition of Pharmacology Condensed, our aim is to pinpoint the essential aspects of pharmacology in a precise manner so that the reader has the confidence to recall or research more detailed material. This approach might be useful for anyone preparing for examinations, or for scientists in need of reprisal of distant and forgotten topics.
Clive Page and Simon Pitchford, London, December 2019
2 Pharmacology, drug names and classification systems
Pharmacology is derived from the ancient Greek word for a drug, pharmakon, and is the study of how drugs and xenobiotics affect body function and also how the body will act on the drug. The use of chemicals to induce a response on the body is as old as time itself, whether through the use of herbal remedies as the earliest forms of medicine, or perhaps the dubious creation of poisons to rid individuals of enemies. Thus the (unintentional) practice of pharmacology might have been considered earlier in history as magic. The intentional formation of pharmacology as
DRUG NAMES
As with the emergence of any scientific discipline, there are a set of codifying rules and an identifiable taxonomy to allow drugs with similar clinical uses, or actions on classes of receptors, to be grouped and classified together via the use of a common naming system.
Drugs will have brand names that are identifiable to consumers and follow no consistent naming pattern. Furthermore, brand names for the same drug may vary from country to country and from manufacturer to manufacturer and therefore should generally not be used. On the other hand chemical names are exact and follow the strict criteria based on their molecular structure by the International Union of Pure and Applied Chemistry (IUPAC). Chemical names are necessary because they allow scientists to interpret the exact structure of a chemical, needed during their synthesis by chemists and by regulatory agencies. Drugs approved
a scientific discipline has evolved from our need to apply scientific principles to create better medicines to improve clinical practice, emanating from an understanding of physiology and pathology, and the earlier exploits of apothecaries to the present creation of a pharmaceutical industry (Fig. 2.1). Pharmacology requires an understanding of other disciplines such as pathology, physiology, biochemistry, synthetic chemistry and molecular biology, and it is underpinned by fundamental physical concepts of mass action and mathematics.
for marketing and pharmacological tools used in research will also often have another non-chemical generic name that identifies their pharmacological classification usually by one of the criteria set out below:
• Therapeutic action
• Pharmacological or molecular mechanism of action
• Chemical nature or source
Of course, not all compounds have a therapeutic indication, as many are used as research tools, and some compounds might not have a known molecular mechanism of action. However, using the different classifications above, salmeterol would be classed as a bronchodilator/sympathomimetic, β2 adrenoceptor agonist, or a phenylethanolamine. Most β2 adrenoceptor agonist names end in rol. The registered brand commercial name for salmeterol is Serevent, a name that provides distinctiveness in the marketplace. Its IUPAC name on the other hand is 2-(hydroxymethyl)-4-[1hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol. Perhaps
Fig. 2.1 The development of pharmacology. (From Rang HP, Ritter JM, Flower RJ, Henderson G. Rang & Dale’s Pharmacology. 8th ed. Philadelphia: Elsevier; 2016.)
Table 2.1 Common endings to official names which indicate the pharmacological classification of a drug
Ending Classification
-olol Β adrenoceptor blocking drug
-caine Local anaesthetic
-dipine Calcium channel blocker of the dihydropyridine type
-tidine H2 histamine receptor antagonist
-prazole Proton pump inhibitor
Prototype for class
Propranolol
Cocaine, procaine
Nifedipine
Cimetidine
Omeprazole -quine Antimalarial drugs
-ane Halogenated hydrocarbon general anaesthetics
-zosin α adrenoceptor blockers (not all)
-profen One class of nonsteroidal anti-inflammatory drugs (NSAIDs)
Decamethonium (but the true pharmacologic prototype is d-tubocurarine)
Diazepam
From Page C, Curtis M, Sutter M, Walker M, Hoffman B. Integrated Pharmacology. 2nd ed. Philadelphia: Elsevier; 2002.
the most useful classification of all these names is the use of β2 adrenoceptor agonist: from this we understand the type of receptor salmeterol acts on, and therefore its primary pharmacological effect. The use of rol in salmeterol also informs us of this precise pharmacological action.
Some examples of pharmacological drug classifications are listed in Table 2.1. The naming of antibodies is also codified, based on structure, and the taxonomy of ‘biologics’ is shown in Figure 8.5 (Chapter 8).
RECEPTORS, ION CHANNELS AND ENZYMES
Pharmacological targets are divided into sections based on structure. The molecular aspects of drug action and classes of receptors, carriers, ion channels and enzymes are discussed in Chapter 4 Similar to the compounds that act on them, the targets also have their own nomenclature and taxonomy. Groupings of similar structures or function are agreed by the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (http://www.guidetopharmacology.org/nciupharPublications.jsp) to include the following seven sections:
• 7-transmembrane spanning receptors (or GPCRs): around 800 exist.
• Ion channels, including voltage operated and ligand gated, represent the second largest target for existing drugs.
• Catalytic receptors, including integrins.
• Nuclear receptors: around 50 identified in the human genome.
• Kinases: around 500 identified in the human genome.
• Transporters: the second largest family of membrane proteins after GPCRs.
• Enzymes: more numerable than receptors, but relatively few are drug targets.
• Other protein targets.
Subtypes of pharmacological targets are denoted usually with an alphanumeric symbol, and this is often, but not always, a subscript. For example, purinergic receptors (P2Y) are designated P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14. The name on its own does not inform as to the principal signal transduction mechanism or the rank order of potency of receptor agonists. Some pharmacological targets might only have one identified family member, for example the platelet-activating factor receptor (PAF-R), but have multiple intracellular signalling pathways.
Pharmacological targets that have no known ligand are referred to as orphan targets.
There is a separate nomenclature committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB) that has responsibility for naming enzymes. Thus, six families based on the reactions that various enzymes catalyse have been created, using a four-number code with an ‘EC’ prefix.
3 General principles of drug action
Pharmacology concerns the study of how drugs affect the function of host tissues or combat infectious organisms. In most cases, drugs bind selectively to target molecules within the body, usually proteins but other macromolecules as well. The main drug targets are receptors, enzymes, ion channels, transporters (carriers) and DNA. There are few instances (e.g. osmotic purgatives and antacids) of drugs acting without binding to a specific target.
It is generally desirable that a drug should have a higher affinity for its target than for other binding sites. First, it ensures that the
RECEPTORS AS DRUG TARGETS
Receptors are protein macromolecules – on or in cells – that act as recognition sites for endogenous ligands such as neurotransmitters, hormones, inflammatory/immunological mediators, etc. Many drugs used in medicine make use of these receptors. The effect of a drug may be to produce the same response as the endogenous ligand or to prevent the action of an endogenous (or exogenous) ligand. A drug (or endogenous chemical) that binds to a receptor and activates the cell’s response is termed an agonist. A drug that reduces or inhibits the action of an agonist is termed an antagonist, and therefore has no biological activity per se.
Receptors are perhaps the most common ‘target’ for a drug, and understanding the interactions between drugs and receptors is a fundamental tenet of pharmacology. Proteins (receptors) are not rigid structures, but due to their inherent kinetic energy, will vibrate, or shimmer, to induce slight variations in shape, such that a receptor will alternate between periods of ‘inactive’ and ‘active’ conformations. Within the vicinity of the receptor, several drug molecules will surround the space. Through random
Inactive
Receptor continually changes conformation over time
Receptor + agonist
Receptor + antagonist
drug’s free concentration (and hence action) is not reduced by nonproductive binding to the much greater number of nontarget molecules in the body. Second, lower doses can be used, which automatically reduces the risks of unwanted actions at other sites that may cause toxicological side effects. Chapter 4 deals specifically with the consequences of drug binding to these targets. The rest of this chapter will deal predominantly with the principles of receptor pharmacology.
motion, during time, occasionally some of those molecules will collide with the ‘active pocket’ of the receptor when it is in the active conformation. This active pocket is commonly known as the orthosteric binding site (Fig. 3.1). Thus when an agonist fits in the active pocket, the receptor is held in the active conformation for a period of time until the agonist is displaced, and this leads to biochemical processes occurring.
The action of an inflammatory mediator, histamine, on bronchial smooth muscle can be taken as an example. There are two aspects to this action:
• The agonist–receptor (drug–receptor) interaction
• The agonist-induced (drug-induced) response
The action of histamine could be measured at various levels: molecular, cellular, tissue and system. With the drug–receptor interaction, we will be dealing with the concepts of affinity, occupancy and selectivity. With the drug-induced response, we will meet the concepts of efficacy and potency:
• Affinity: The ability of a drug to bind to a receptor.
• Occupancy: The proportion of receptors to which a drug is bound.
Receptor held in active conformation for longer to increase probability of signalling
Receptor held in inactive conformation for longer to decrease probability of signalling
illustrating a receptor occupied by agonist or antagonist and the influence of conformation and time on the probability of a biological response
Fig. 3.1 Schematic diagram
illustrating receptor (R) occupied by agonist A (e.g. histamine) on the surface of
so that [A][R] [AR] = k1 k + 1 = KA
k+1 and k-1 have the units M-1 sec-1 and sec-1 respectively. KA (equal to k-1/k+1) is the dissociation equilibrium constant for the binding of drug to receptor; it has the dimensions of concentration and is used by pharmacologists rather than an ‘association’ constant, which confusingly has the units L/mol. (It is the reciprocal of the affinity constant, i.e. the higher the affinity of the drug for the receptors, the lower the value of KA.) A high KA specifies a low affinity, which means that there are fewer drug–receptor complexes overall.
The relationship at equilibrium between KA, the concentration of agonist drug, and the proportion of receptors occupied (i.e. the occupancy pA) is given by:
muscle. This is self-evident (i.e. the concentration of receptors o occupied over the total receptor concentration)
• Selectivity: Relative affinity or activity of a drug between different receptor types. Largely replaced the concept of specificity, since it is improbable that any drug is specific for a particular receptor.
• Efficacy: The ability of an agonist to elicit a response following binding.
• Potency: A measure of the concentration of a drug (agonist or antagonist) at which it is effective.
The agonist–receptor (drug–receptor) interaction
In Fig. 3.2 as an example of a tissue, the smooth muscle surface (which can be stimulated by histamine) is represented by the blue curved segment. The receptors (shown as cups) are representative of the total number of receptors on the muscle (Rtot). The histamine molecules are represented by the grey circles. When the muscle is exposed to a concentration of histamine [A] and allowed to come to a dynamic equilibrium, where the drug occupation of a number of receptors (AR) at any point is steady. We now need to consider the relationship between [A] and the occupancy of the receptors [AR]/[Rtot].
Drug–receptor interaction is usually freely reversible and can be represented by the following equation:
(The rate constant forthe forward(association) reaction)
(The rate co () n nstantfor the backward(dissociation)reaction)
The Law of Mass Action (the rate of the reaction is proportional to the product of the concentrations of the reactants) can be applied to the reaction. At equilibrium the forward and reverse rates are equal, i.e.: k + 1 [A][R] = k1 [AR]
But this may not be obvious to every student; it is the Hill Langmuir equation
The value of KA is equal to the concentration of the agonist drug that at equilibrium results in occupancy of 50% of the receptors. For example, if the concentration of the drug is 10 μmol/l and the KA is 10 μmol/l, then:
PA = 10 10 + 10 =0 5
The relationship between occupancy and drug concentration specified by the Hill–Langmuir equation (identified above) can be represented graphically as shown in Fig. 3.3. The theoretical curves given are for occupancy. Now let us consider the agonist-induced response.
The agonist-induced (drug-induced) response
An agonist-induced response – if it is a graded response – can be plotted as a concentration–effect or dose–response curve ( Fig. 3.4 ). The concentration producing a response 50% of the maximum is termed the EC 50 (EC, effective concentration).
Can one make the assumption that responses such as these are directly proportional to occupancy at the relevant receptors?
Certainly the log concentration–response curve in Fig. 3.4 looks very like the theoretical log concentration–occupancy curve in Fig. 3.3. However, even with the simple in vitro response of smooth muscle to noradrenaline, it is not possible to know, with certainty, the concentration of drug at the receptors. Factors such as enzymic degradation, binding to tissue components, problems related to diffusion of drug to the site of action, and so on, complicate the picture.
The relationship between occupancy and response is in most cases unknown and, almost certainly, not linearly related to occupancy. Consequently, although concentration–response (or dose–response) curves look very similar to concentration–occupancy curves, they cannot be used to determine the agonist affinity for the respective receptors.
The dose that produced a 50% of a maximal response using in vitro preparations (EC50), and ED50 for in vivo preparations
Fig. 3.2 Schematic diagram
smooth
Fig. 3.3 Occupancy, according to the Hill–Langmuir equation, plotted against drug concentration The graph has been drawn according to a KA value of 1 μmol/l. When the concentration of the agonist also equals 1 μmol/l, the occupancy of receptors is 50%.
(ED, effective dose), or when discussing a population response ED50 will represent 50% of the individuals responding.
With some drugs, the maximum response produced corresponds to the maximum response that the tissue can give. These are termed full agonists. The action depicted in Fig. 3.4 is that of a full agonist. Other drugs, even though acting on the same receptors, may not give the maximum tissue response in any concentration (Emax). These are termed partial agonists. Therefore it is always important to have knowledge of the EC50 (or ED50) to compare drug potency, and Emax to compare efficacy
Partial agonists
The concentration–response curves of some full and partial agonists on the muscarinic receptors of smooth muscle of the gastrointestinal tract are shown in Fig. 3.5. It can be seen that both acetylcholine and propionylcholine are full agonists but propionylcholine requires a larger concentration to produce a maximum response. Butyrylcholine even in very high concentration never produces as great a response as acetylcholine – it is a partial agonist.
What is the explanation for the different responses of partial and full agonists? Experiments have shown that this is not because the partial agonists bind to fewer receptors, but that they are less
Fig. 3.4 The concentration–response curve for noradrenaline (NA)-mediated contraction of smooth muscle in vitro
Fig. 3.5 Log dose–response curves for full and partial agonists on gastrointestinal smooth muscle. ACh, Acetylcholine; PCh, propionylcholine; BCh, butyrylcholine.
able to elicit a response from the receptors to which they do bind. They are, in fact, less potent. They are said to have less intrinsic activity (or lower efficacy).
Efficacy
Efficacy is a complex concept that, in simple terms, describes the ability of the drug (agonist), after binding to the receptor, to activate transduction mechanisms that lead to a response.
Partial agonist action can be best interpreted in terms of a two-state model of the molecular events at a single receptor on interaction with agonist A. The model envisages that an occupied receptor can exist in two states: a ‘resting’ state (R) and an ‘activated’ state (R*). This is represented in Fig. 3.6 which shows the distinction between drug binding and receptor activation.
Another random document with no related content on Scribd:
further change, but he leaves later steps to later times. His faith is that if the next step taken by us is important and of right direction we shall have done all that belongs to our moment.” Contents: In time of revolution; The storm cellar; The blockade of thought; What the issues are; Without a party; Facing bolshevism: our follies in Russia; Facing bolshevism: the future in Russia; Is socialism needed? The answer of cooperation; The answer of liberalism; From Wilsonism to the future; What is our faith?
“A hopeful book which does not attempt to solve all problems at a stroke.”
Booklist 17:13 O ’20
“Mr Hapgood always writes interestingly even though his words may not be based upon the soundest philosophy.”
Cath World 112:403 D ’20 330w
“Outside of an excellent chapter on the cooperative movement, the volume is chiefly pious platitude, amiable advice to business men not to make fools of themselves in a time of rapid social change like the present.” Harold Stearns
Freeman 2:92 O 6 ’20 960w
Reviewed by W: MacDonald
Nation 111:sup427 O 13 ’20 750w
“It is a book worth everyone ’ s reading, for its notable contribution of facts and ideas, and more especially for its candor of spirit, rare indeed in a day when a great part of our political writers are still more or less disabled morally by their late services to national morale in disseminating lies and misrepresentations for the glory of God and the cause of right.” A. J.
New Repub 23:339 Ag 18 ’20 2050w
“Mr Hapgood shows the defects of his good qualities and one of these is at present a lack of knowledge in what these good qualities consist. The volume is stimulating, patriotic without being nationalistic, unselfish and idealistic; but it shows some of the defects of an education which seems to have been entirely American.” M.
F. Egan
N Y Times p8 Ag 29 ’20 3550w
“The best chapter in the book is chapter eight on the advantages of co-operation, over both socialism and government regulation of great combinations, as a remedy for industrial injustice. Mr Norman Hapgood is an effective pamphleteer; but excellences in a pamphleteer are fatal defects in a historian.”
Outlook 126:111 S 15 ’20 300w
“To one reviewer at least and one who is not insensible to the part Mr Hapgood has taken in past times in the advocacy of certain social measures there is provocation on almost every page of this book. But in the two chapters on the Russian problem, as well as in other incidental treatment of this problem, the provocation concentrates in every line.” W. J. Ghent
3:230 S 15 ’20 3350w
R of Rs 62:333 S ’20 130w
“To see things steadily and clearly is a gift of few. Mr Hapgood possesses fewer blind spots than most, but it may be that he is mistaken in parts of his analysis. However, he stimulates the reader to formulate his own beliefs. The style is a trifle labored, but there is no mistaking the book’s earnestness.”
Springf’d Republican p8a S 19 ’20 320w
“Special mention should be made of Mr Hapgood’s intimate study of President Wilson. It is a helpful antidote to Mr Keynes’ sketch.” L. R. Robinson
Survey 45:320 N 27 ’20 720w
HARA, KATSURO.[2] Introduction to the history of Japan. *$2.50 (2½c) Putnam 952
The book is the first of a projected series of publications by the Yamato society, whose aim is to make clear the meaning and extent of Japanese culture to other nations, and to introduce the best literature and art of foreign nations to Japan for a promotion of a common understanding. The present volume is intended for those Europeans and Americans who would like to know Japan “not as a land of quaint curios and picturesque paradoxes only worthy to be preserved intact for a show, but as a land inhabited by a nation
striving hard to improve itself, and to take its share, however humble, in the common progress of the civilisation of the world.” (Preface) Contents: The races and climate of Japan; Japan before the introduction of Buddhism and Chinese civilisation; Growth of the imperial power; gradual centralisation; Remodeling of the state; Culmination of the new régime; stagnation; rise of the military régime; The military régime; the Taira and the Minamoto; the shogunate of Kamakura; The welding of the nation; the political disintegration of the country; End of medieval Japan; The transition from medieval to modern Japan; The Tokugawa shogunate its political régime; culture and society (two chapters); The restoration of the Meidji; Epilogue. The objects of and the rules of the Yamato society are given in full and there is an index.
“A carefully evolved and well written synopsis of the many centuries of Japanese national life. There is one especially creditable circumstance about the publication of this book. It is honest Japanese propaganda, and it makes no pretensions of being anything else.” S. L. C. Boston Transcript p4 Ja 22
WILLIAM
NATHANIEL.
Divine event. *$1.75 (2c) Harper
20–16796
A story of psychical phenomena. Hillery Gramling, unhappy over the death of his brother, in consultation with a medium is sent to New York’s East side to live among the poor. There he comes in contact with Lucia Lingle, a beautiful young girl who seems to be under the shadow of some awful, mysterious tragedy. He falls in love
with her and is anxious to help her. He is aided by Professor Trimble, psychologist, alienist, mental scientist, who becomes deeply interested in Lucia’s case. Thru the mediumship of Madame DuFresne, they discover the exact nature of her trouble, that her half-brother is trying to prove her insane that he may take over her inheritance. Together they fight the thing out, encouraged always by the supernatural aid they receive, thru Madame DuFresne, from those on the other side of death. In the end thru their combined efforts, Lucia is freed from the awful curse that has hung over her, and has the promise of happiness.
“The plot is slight and unconvincing but is evidently meant to be taken seriously and will interest readers inclined to believe in spirit control and guardian angels.”
Booklist 17:158 Ja ’21
HARCOURT, ROBERT HENRY. Elementary
forge practice. 2d ed, enl il $1.50 Manual arts press 672
20–19056
A second edition of a work originally published by the author, instructor in forge practice in Leland Stanford Junior university, where it has been used as a text. It is designed for use in technical and vocational schools. Contents: Materials and equipment; Drawing-out, bending and twisting; Common welds; Special welds; Hammer work; Annealing, hardening and tempering steel; Tool forging. There are forty-four plates illustrating as many projects.
“The volume should prove a valuable addition to any shop library as a supplementary text. For the teacher of large classes of beginners it should lift the burden of much class work and explanation if placed in the hands of the pupils as a text.”
School R 29:77 Ja ’21 210w
HARD, WILLIAM. Raymond Robins’ own story.
(4c) Harper 947
20–3007
Colonel Robins was the unofficial representative of the American ambassador to Russia for eighteen months and a close observer of the powers that conducted Russian affairs, and he has had a more intimate acquaintance than any other American or allied representative with the government of Lenin. He is not a socialist and not a bolshevist, but he sees that the danger from the latter, if such there be, lies not in riots and robberies, mobs and massacres, not in its disorder but in its order, in that “the Soviet system is genuinely a system on its own account.... It can be extinguished only in the free air of fair controversy and of fair, practical proof.” There is but one choice left to America, according to Colonel Robins, in dealing with Russia, and that is not intervention but intercourse. The story of the book is told by the author as it was narrated to him by Colonel Robins. The contents are: The arrival of the Soviet; Trotzky’s plans for soviet Russia; The all-Russian congress and the BrestLitovsk peace; The personality and power of Nikolai Lenin; The bolshevik “bomb”; and many illustrations.
Booklist 16:237 Ap ’20
“It stands out in this consecutive form as the most vigorous, the most picturesque, as well as the most truthful record in English of the birth of Bolshevism through the Soviet.” O. M. Sayler
Bookm 51:310 My ’20 950w
Cleveland p76 Ag ’20 60w
R of Rs 61:446 Ap ’20 180w
Springf’d Republican p8 Ap 1 ’20 1000w
“Mr Hard is so carried away with dramatic fervor that he feels it necessary to interrupt himself every now and then to assure us that Mr Robins is a good anti-Bolshevist. But these interludes need not divert the reader from the important parts of the book. Mr Robins’ admirable suggestions as to future American policy toward Russia deserve to be widely read.” Reed Lewis
“This book contains all of Thomas Hardy’s poetry except ‘The dynasts,’ including poems which have appeared in his prose works.” Booklist
“There have been many poets among us in the last fifty years, poets of sure talent, and it may be even of genius, but no other of them has this compulsive power of Hardy. The secret is not hard to find. Not one of them is adequate to what we know and have suffered.... Therefore we deliberately set Mr Hardy among the greatest.” J. M. M.
Ath p1147 N 7 ’19 2200w
Booklist 17:21 O ’20
“Let it be said straight out that in our opinion, whatever else Mr Hardy’s writing, susceptible to scansion, is, it is not poetry. It is not poetry, because, in the end, poetry is in a sort illusion.... He has been guilty of the last, the unforgivable sin in poetry—* *he has sinned against love, for which there is and should be no forgiveness.”
Sat R 128:459 N 15 ’19 1250w
Spec 122:512 O 18 ’19 20w
“Mr Hardy, once and for all, set up as poet, then, at an age when Shakespeare left our mortal stage. This book, for that reason alone, is an unprecedented achievement. Apart from that, to read steadily through it and what severer test of lyrical poetry could be devised? —is to win to the consciousness not of any superficial consistency, but assuredly of a ‘harmony of colouring’; not, however keen the joy manifest ‘in the making,’ of an art become habitual, but of a shadowy unity and design.”
The Times [London] Lit Sup p681 N 27 ’19 2450w
HARKER,
MRS LIZZIE ALLEN. Allegra.
*$1.75 (2c) Scribner
20–161
Allegra is a charming but decidedly self-centered young actress who sees every person and every incident in the light of her career. She is playing in a provincial repertory theater at the opening of the story and it is thru a chance meeting with Paul Staniland that her ambition to appear in London is gratified. Paul is delighted with Allegra and works up a part for her in the play he is dramatizing from one of Matthew Maythorne’s novels. Maythorne is one of those popular novelists whose books sell into the thousands and he fatuously accepts the success of the play as a tribute to himself, giving Paul none of the credit. Allegra’s admiration for the novelist is killed by a reading of his book and she comes to appreciate Paul, but a visit at the country home of Paul’s people, delightful tho they are, convinces her that she belongs to the theater and she returns to the stage. Ath p1208 N 14 ’19 70w
“The plot is not credible in parts, but this does not mar the interest of the story.”
Booklist 16:244 Ap ’20
Reviewed by M. E. Bailey
Bookm 51:205 Ap ’20 260w
“If Paul seems a special creation made to fit Allegra’s need, why quarrel with him? Are we not left with the conviction that here is a really happy ending to a story?”
Boston Transcript p6 Mr 24 ’20 260w
“A number of minor characters are very well drawn.”
Cleveland p50 My ’20 70w
“All the minor characters, in fact, are skillfully portrayed, with any number of quaint and understanding little touches which make ‘Allegra’ very agreeable reading the more agreeable because the author has had the good taste and good sense to avoid the conventional ‘happy ending.’”
N Y Times 25:71 F 8 ’20 440w
Sat R 130:380 N 6 ’20 100w
“Altogether it is a slight but pleasing little story without any probing into psychology or any tremendous conflict of forces.”
Springf’d Republican p11a Ap 11 ’20 160w
“Allegra, a little hard and egotistical, and passionately devoted to her art, is well studied. And the whole tale (which moves among wellbred people throughout) is on a good level, though we think a little below that attained in other books by the author.”
+
The Times [London] Lit Sup p594 O 23 ’19 100w
HARPER, GEORGE MCLEAN.[2] John Morley, and other essays. *$1.60 Princeton univ. press 814
20–10290
“Professor Harper, of Princeton university, author of various books of literary criticism (including the substantial and able work on Wordsworth), here puts together eight essays on John Morley; Victor Hugo (these from the Atlantic Monthly); Michael Angelo’s sonnets; Balzac; W. C. Brownell (an American critic); Wordsworth at Blois; Wordsworth’s love poetry; and ‘David Brainerd: a Puritan saint.’” The Times [London] Lit Sup
“His generalizations are just, and he is not ridden by them; he knows when to generalize and when to forget his generalizations.”
Ath p838 D 17 ’20 110w Booklist 17:68 N ’20
The Times [London] Lit Sup p762 N 18 ’20 70w
HARRIS, CORRA MAY (WHITE) (MRS LUNDY HOWARD HARRIS). Happily married. *$1.75 (2c) Doran
The scene is an exclusive southern town, the time that summer of intense war activity, 1918, and the characters several married pairs. Two of these are Mary and Pelham Madden, and two others Ellen and Barrie Skipwith. Mary is one of those calm, maternal and beautifully placid women, a perfect housekeeper and mother of four children. Ellen is a childless woman with red hair and baby blue eyes. Mary has just found a note in her husband’s pocket addressed to Dear Pep. Ellen has just turned in a Red cross subscription list with an anonymous contribution of $1000. How Mary wakes up and learns to practice the old womanly wiles is the theme of a story that is told amusingly with touches of satire.
“Entertaining in spite of its hackneyed plot.”
Booklist 16:281 My ’20
“Mrs Harris makes no attempt to inject novelty into the situation. She relies on her knowledge of men and women and her happy faculty in phrasing her reflections thereon for the pleasure of her readers. And these easily suffice.” F. A. G.
Boston Transcript p11 Mr 27 ’20 500w
“The entertaining and shrewd comment upon married life, adds ginger to a somewhat conventional vamp story.”
Cleveland p71 Ag ’20 100w
Lit D p99 My 1 ’20 2300w
“An immense quantity of mildly entertaining and occasionally shrewd comment strung on a very slight, very much worn thread of plot, constitutes Corra Harris’s new novel.”
N Y Times 25:4 F 29 ’20 300w
Outlook 124:562 Mr 31 ’20 30w
“Mrs Harris’s thesis does not command unfaltering acquiescence. For those, however, who collect novels as others collect butterflies, the book will have a great deal of interest.”
The Times [London] Lit Sup p383 Je 17 ’20
500w
HARRIS, CREDO FITCH. Wings of the wind.
*$1.75 (1½c) Small
20–11301
Jack Bronx, returning from the war, is packed off by his fond parents on their private yacht, with one of his army pals. On the way to Havana they pick up a stranger who turns out to be a secret envoy from the Kingdom of Azuria, in search of a lost princess. Chance favoring they trace the princess as one of the passengers on another yacht. Great is the chase, thrilling the adventures which eventually take the party to the Florida swamps into the ancient haunts of the Seminoles. The princess is rescued, Jack falls violently in love with her, and the old emissary hard put to it to save her, under the circumstances, for the throne of Azuria. Jack’s resourceful friend settles the matter by demonstrating to everybody’s satisfaction that
the emissary’s orders to deliver the princess did not contain the provision that she must be single when found.
Boston Transcript p6 Jl 28 ’20 650w
“The story teems with thrilling incidents. The plot, however, is trite.”
Cath World 112:552 Ja ’21 90w
N Y Times 25:28 Jl 25 ’20 530w HARRIS, H. WILSON. Peace in the making. il
“‘What I have endeavored to produce is an account, checked by such official documents as are available, which will convey to the general reader some not wholly inadequate impression both of what the conference did and how it did it.’ (Preface) The author was for three months the special correspondent of the London Daily News to the conference.” Wis Lib Bul
Ath p95 Ja 16 ’20 200w Booklist 17:66 N ’20
“Mr Harris is well-informed and his pen-pictures of the personality and policy of the leading diplomats, tho less lively than those of Mr Keynes, are far closer to the facts.”
Ind 103:187 Ag 14 ’20 50w
“His plan is less ambitious than that of Dr Dillon, for he leaves out most of the historical summaries which are a valuable feature of Dr Dillon’s volume, and also tells fewer incidents. His account of the Prinkipo episode, and of the apparently deliberate intermeddling of France to insure that the proposed conference should come to naught, should be read by anyone who still cherishes confidence in the good faith of the Paris negotiators.” W: MacDonald
Nation 111:246 Ag 28 ’20 150w
N Y Times p15 S 19 ’20 50w
“Those readers who are interested in finding an account of the peace conference to supplement the somewhat opinionated statements of Keynes and Dillon would do well to provide themselves with a copy of ‘The peace in the making.’ The book as a whole, while not itself history in the fullest sense, may well be regarded as a contribution to history.”
R of Rs 61:669 Je ’20 140w
Springf’d Republican p9a Ag 29 ’20
220w
“His summary of the deliberations of the conference is just a little too summary, and the chapter on Lenin and Bela Kun is vague and
+ unsatisfactory. On the other hand, Mr Harris’s judgments of the personalities of the conference are generally temperate and just.”
The Times [London] Lit Sup p23 Ja 8 ’20 220w
Wis
Lib Bul
16:119 Je ’20 60w
HARRIS, JAMES RENDEL. Last of the Mayflower. (Manchester univ. publications) *$2 (*5s) Longmans 974.4
20–14551
“In this publication of the John Rylands library Dr Rendel Harris tries to find an answer to the question, ‘What became of the “Mayflower“?’ The name was a common one for ships in late Tudor and early Stuart times; hence the tracing of the authentic ‘Mayflower’ has entailed much research. Some ten years after the landing of the Pilgrims (1620), she was employed on a similar service, that of transporting the remainder of the Leyden colony to New Plymouth. Then she is traced in the whale-fishery, and to her last owner and master, Mr Thomas Webber of Boston. Not long after 1654, the author says, ‘ one is tempted to conjecture that she died (in a nautical sense). Most likely she was broken up in Boston, or perhaps in the Thames on her last voyage to London.’ ” Ath
Ath p591 Ap 30 ’20 140w
Reviewed by W. A. Dyer
Bookm 52:125 O ’20 40w
HARRISON, AUSTIN.
Before and now. *$1.75 (2½c) Lane 304
20–6972
This collection of papers, reprinted in a revised form from the English Review, are critical and partly satirical and humorous impressions of conditions in England previous to and during the war. They were “journalism then, today they are prophetic,” says the author. It is the disintegration of old conceptions and the birth-pangs of new that form the subject-matter of the papers, which are: Jingoism; The coming of Smith; “Surrey in danger”; Peace, perfect peace; St George’s stirrup; The duke’s buffalo; A “Christian” Europe and afterwards; Our gentlemen’s schools; Authority and privilege; The new “Sesame and lilies”; The Christian drum; What is ours is not ours; The country of the blind; “Leave them ‘ orses alone!”; Foreign politics; “Minny”; The awakening; Musings at Fort Vaux; Foundations of reconstruction.
“Some of these reprinted articles from the English Review are worth reading again, as the contemporary views of a very independent critic.”
Ath p1136 O 31 ’19 120w
“Although the intimate knowledge of men and events which the author demands of his readers will be a drawback to many, the
interest of his criticisms will hold the attention of the more thoughtful and well informed.”
Booklist 16:305 Je ’20
“The papers are stimulating and thoughtful.” W. S. B.
Boston Transcript p7 Ap 14 ’20 480w
“Mr Austin Harrison is unfortunate enough to live in a betweenage. Actually he belongs to the Victorian era, but his generation and his intelligence will not leave him at peace, and push him into a rather uncomfortable ultra-modern attitude. Of all his essays the musings at Fort Vaux are the most illuminating, because they are at once the most sincere, the least preconceived.”
Nation 111:224 Ag 21 ’20 220w
N Y Times p17 S 12 ’20 50w
“What he has given us is very suggestive, and one is grateful to any man who can stir up general interest in our social problems by the use of such a facile pen. He has the same sort of literary gift as Mr H. G. Wells, though in a slighter degree. But he has not so far shown anything like the rich literary nutritiousness that belongs to the work of his distinguished father [Frederick Harrison].” H. L. Stewart
Review 2:600 Je 5 ’20 1000w
“Mr Harrison has a vigorous and effective pen, which often runs away with him and never quite knows when to stop; but his chief
+ fault, as this book reveals it, is a love for exaggeration which detracts considerably from the value of his words.”
The Times [London] Lit Sup p609 O 30
’19 1150w
HARRISON, MARY ST LEGER (KINGSLEY) (MRS WILLIAM HARRISON) (LUCAS MALET, pseud.). Tall villa. *$1.75 (4c) Doran
20–3
The outstanding characteristic of this novel is that it is a ghost story. After her husband’s financial failure, Frances Copley betakes herself away from Grosvenor square and London high society and buries herself in Tall villa, a maternal inheritance and a preposterous piece of architecture, while her husband goes to seek a new fortune in South America. There the ghost of an ancient relative, a suicide from disappointed love, makes itself known to her and moved by pity she resolves to consecrate her life to his redemption. They hold daily concourse and by the time his earth-bound spirit has been released through her martyrdom, the latter for her had turned into rapture. Her spirit too, now longs for release and when the ghost makes its final appearance it is to free her too from earthly thralldom.
Ath p767 Je 11 ’20 460w
“The story is kept sane by means of the other people, the Bulparcs, Lady Lucia and her baby, and Charlie Montagu. Therefore it is
cleverly done. But no one who has not been drawn by a spirit lover to the fairer clime can tell if the rest of it is really correct. To review the volume rightly one needs a ouija board.”
Boston Transcript p6 Ag 14 ’20 520w
“The story, a modern fairy tale, is handled with much restraint and artistry.”
Cleveland p50 My ’20 50w
Dial 68:665 My ’20 50w
“Those who are desirous of finding something to laugh at and to ridicule in any tale of the supernatural will readily discover all that they desire in ‘The Tall villa’; even those who are ready and willing to take the novel with the same high and intense seriousness with which it is written will find it difficult to refrain from smiling over some of the high-flown speeches addressed by Frances Copley to the ghost of Alexis Lord Oxley. Yet there is much of charm in the book.”
N Y Times 25:2 F 22 ’20 900w
“The character of Frances Copley is exquisitely etched. The rare distinction of Mrs Harrison’s carven style is at its best in this unusual and dexterously handled romance, which is finely free from the overfrank emphasis of the senses found in ‘Sir Richard Calmady.’”
Katharine Perry
Pub W 97:601 F 21 ’20 400w
“The book will rank with the best of the author’s.”
Sat R 130:300 O 9 ’20 110w
“It is a sad confession to make, but we are Philistine enough to prefer those portions of the story in which normal events and personages predominate.”
Spec 124:728 My 29 ’20 450w
“The dialog is invariably stilted, and the generally formal tone robs the situation of reality and those startling qualities inherent in it. The heroine herself is delicately portrayed. The story is not long and stirs only a mild interest.”
Springf’d Republican p11a My 9 ’20 560w
“This novel is excellently written; but a ghost story should make the flesh creep, and that is the one function which, in spite of its excellences, it certainly does not perform.”
The Times [London] Lit Sup p284 My 6 ’20 460w HARROW, BENJAMIN.[2] Eminent chemists of our time. il *$2.50 Van Nostrand 540.9
The author has chosen eleven scientists “whose work is indissolubly bound up with the progress of chemistry during the last generation or so. ” His aim has been “to write a history of chemistry
of our times by centering it around some of its leading figures.”
Contents: Introduction; Perkin and coal-tar dyes; Mendeléeff and the periodic law; Ramsay and the gases of the atmosphere; Richards and atomic weights; Van’t Hoff and physical chemistry; Arrhenius and the theory of electrolytic dissociation; Moissan and the electric furnace; Madame Curie and radium; Victor Meyer and the rise of organic chemistry; Remsen and the rise of chemistry in America; Fischer and the chemistry of foods. Reading references follow the chapters and there is an index.
HARROW, BENJAMIN. From Newton to Einstein; changing conceptions of the universe. il *$1 (6½c) Van Nostrand 530
20–7594
The booklet gives in simple popular language an outline of Newton’s great discovery and of the various steps in scientific achievements which led up to Einstein’s conception of the universe and theory of relativity. It shows how Einstein’s conception of time and space led to a new view of gravitation and explains some facts which Newton’s law was incapable of explaining. The three essays of the book are: Newton; The ether and its consequences; Einstein.
“Dr Harrow’s account is altogether too inadequate. The chapter on ‘Einstein’ utterly fails to bring out the central conceptions of the ‘Relativity theory’; it is not that the treatment is obscure; it is that very important points are slurred over, misstated, or ignored.” Ath p377 S 17 ’20 240w Booklist 17:57 N ’20
“It contains egregious mistakes, minor errors, misplaced emphasis, wrong interpretation, and a modicum of information.” R: F. Deimel
Freeman 1:423 Jl 14 ’20 60w
Nature 106:466 D 9 ’20 40w
N Y P L New Tech Bks p36 Ap ’20 70w
“A lucid little book.”
The
Times [London] Lit Sup p603 S 16 ’20 20w
HARTLEY, OLGA. Anne. *$1.90 (2c) Lippincott
Anne is an orphan and still a child at seventeen when young Gilbert Trevor, one of her self-appointed guardians, falls in love with and marries her, while her other self-appointed guardian, John Halliday, continues to hover over her with a more selfless devotion. Anne never grows up but remains an ardent, wilful, fascinating child with a child’s sincerity and purity of heart. It leads her into dangerous situations and causes complications during which, at a crucial moment, Gilbert fails her. She forces the estrangement and after some mad escapades follows the dying John to Scotland, resolved to give him all the love that he deserved and of which Gilbert has proved himself unworthy. But the latter’s love and manhood stand the final test and his protecting arms once more hold Anne safe.
“Anne’s future sister-in-law, Francesca, is a likeable character; but the heroine herself is difficult to understand, almost to the end of the book.”
Ath p783 Je 11 ’20 100w
“The author’s handling of the heights and depths of the story towards its climax deserves high praise for restraint, for absence of sensationalism while it yet holds and thrills.”
Cath World 112:407 D ’20 260w
“Whether one has patience with the violent-tempered, erratic heroine or not, it cannot be denied that here is a soundlyconstructed, well-written novel.”
N Y Times p26 D 19 ’20 260w
Reviewed by Caroline Singer
Pub W 98:658 S 18 ’20 300w
“The development and gradual ripening of the heroine’s character (she needed it) are very well done, and we commend the book to our readers.”
Sat R 130:379 N 6 ’20 80w
HARTMAN, HARLEIGH HOLROYD. Fair value. *$2.50
Houghton 338
20–6119
The book is one of the series of Hart, Schaffner, and Marx prize essays in economics and the thesis is concerned with the meaning and application of the term “Fair valuation” as used by utility commissions. The usage of the term is a loose one and open to much confusion on the part of the public as well as of the courts. The author’s inquiry rests on the points: “that the public utility is essentially different from other industry; that private property devoted to the public use is not the same as other private property, and does not enjoy the same legal protection; that the service rendered is governmental in its nature, and; that the purpose of regulation is curtailment of ‘private rights’ and the encumbrance of ‘private property.’” The book falls into two parts: 1, The meaning of the term “fair value” contains: The basis of regulation; The purpose of regulation; Valuation and regulation; The theory of valuation; Valuation methods. 2, The application of the theory of fair value, contains: The valuation of tangible property; Valuation of intangible property; Depreciation; The return on the investment; Conclusion. There is also a selected bibliography, a table of cases, and an index.
“The first is far the more significant part. A valid criticism of the book is that it overstrains legal definitions and logical legal relationships.” J: Bauer
+
Am Econ R 10:822 D ’20 880w
“A useful and opportune classifying of a large mass of scattered material.”
“‘Fair value’ is, withal, a most exhaustive and illuminative work on current economics, with principles, laws, court decisions and commission opinions all set forth in such a fashion that even the uninitiate in such matters are able to grasp Mr Hartman’s theories of valuation.” G. M. H.
Boston Transcript p11 My 22 ’20 550w
Review 3:448 N 10 ’20 1100w
R of Rs 62:447 O ’20 120w
Reviewed by E. R. Burton
Survey 44:541 Jl 17 ’20 340w
Plays of the Harvard dramatic club. *$1.25 Brentano’s 812.08
“The little volume of one-act plays, edited by Professor George Pierce Baker, contains only four pieces, all of them dealing with American themes and all of them the result of their several authors’ studies in the dramaturgic laboratory which the editor has successfully conducted at Harvard. In his brief prefatory note he explains the activities of the Harvard dramatic club and tells us that the four plays he has chosen for inclusion have been selected ‘ as a
group which perhaps gives the volume best variety and balance.’” (N Y Times) The titles are “The harbor of lost ships, by Louise Whitefield Bray; Garafelia’s husband, by Esther Willard Bates; The scales and the sword, by Farnham Bishop; and The four-flushers, by Cleves Kinkead.” (Brooklyn)
Brooklyn 12:66 Ja ’20 30w
“Professor Baker has worked earnestly, unostentatiously, and with only one failing, a somewhat lively fear of being academic.” K. M.
Freeman 2:310 D 8 ’20 190w
Reviewed by Brander Matthews
N Y Times p10 Ag 8 ’20 150w
HARVEY, LUCILE STIMSON. Food facts for the home-maker. il *$2.50 Houghton 613.2
20–6498
The book is intended to help the young housekeeper without either knowledge of science or technical skill, and to give the experienced cook a scientific foundation, but primarily to show mothers how to feed their children. “Few women realize the great importance of the proper feeding of the family. Undernourishment among our children in the United States is far more prevalent than is generally supposed, and is found quite as often in the homes of the well-to-do as in those
of the poor. ” (Preface) Although the book contains recipes it is not intended to compete with cook-books, but rather to supplement them. Among the contents are: The importance of food; The composition of foods; Milk and eggs; Meat; Cheese and legumes; Cereals; Fruits and vegetables; Fats; Sugar; The use of food in the body; The measurement of food values; Food for infants and young children; Food for school-children; Food for invalids. There is a bibliography and an index.
Booklist 16:334 Jl ’20
“A highly important and serviceable book.”
Boston Transcript p6 Ap 28 ’20 230w
“Throughout the volume is an excellent manual that is well arranged, written in an informal and untechnical vein and well fitted to meet the demands of the ordinary household.”
Springf’d Republican p13a Ap 25 ’20 140w
Reviewed by E. A. Winslow Survey 44:592 Ag 2 ’20
A story for girls with a vocation moral. In their junior year in high school a group of friends form the V. V. club (the initials standing for vacation-vocation), and in the chapters of the book their various experiences in the world of work are followed. After college one group goes to New York to attack business, advertising, interior decorating and tearoom management. One girl stays at home and finds her vocation in a recreation center. One country girl leaves the farm to go to college and then comes back to teach a country school and make over a rural community. One girl, who is a misfit in business, succeeds as athletic director and organizer of a summer camp. The girls are bright and natural, the stories are interestingly told and the romance that has a part in all real-life stories is not omitted.
HASKINS, CHARLES HOMER, and LORD, ROBERT HOWARD. Some problems of the Peace conference. *$3 Harvard univ. press 914.314
20–12208
“It will be remembered that Professor Haskins and Professor Lord were two of the experts who accompanied President Wilson to the peace conference. Prof. Haskins served as chief of the division of western Europe and he was American member of the special committee of three which drafted the treaty clauses on AlsaceLorraine and the Sarre valley. Professor Lord served as American adviser on Poland and related problems, both at Paris and in Poland itself. The lectures published in this volume were delivered last winter at the Lowell institute and are now given with only incidental changes. The effort of the two men has been to present each of these problems in its historical setting, revealing at the same time, the reason of its importance to the conference.” Boston Transcript
“In respect both to extent and to content, the book leaves much to be contributed to the subject in the future, by the present authors or by other scholars. It does provide what is most needed at this time, a well-informed and fairminded sketch of the background and of the probable issue of the territorial settlement. One noteworthy contribution of the book is the first chapter on Task and methods of the conference.” Clive Day
Am Hist R 26:334 Ja ’21 1400w
“May be regarded, without question, as the most important work on the conference that has yet appeared. It should do much to counteract the overdrawn and splenetic sketches of Keynes, Dillon, or Creel.” C: Seymour
Am Pol Sci R 14:734 N ’20 420w
“It is improbable that this particular book, with the accurate knowledge it displays and the authoritative position which its authors held in the actual negotiations, will ever be replaced as an historical record.”
Boston Transcript p7 Ag 14 ’20 280w
“By far the best account of the Paris conference which has yet appeared.”
