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HANDBOOK OF Retinal OCT
Editors
Jay S. Duker, MD
Director, New England Eye Center Professor and Chair, Department of Ophthalmology
Tufts Medical Center
Tufts University School of Medicine Boston, MA USA
Nadia K. Waheed, MD, MPH
Professor in Ophthalmology
New England Eye Center
Tufts Medical Center
Tufts University School of Medicine
Boston, MA USA
Darin R. Goldman, MD
Vitreo-retinal Surgeon Partner, Retina Group of Florida Clinical Affiliate Associate Professor of Surgery
Charles E. Schmidt College of Medicine Florida Atlantic University Boca Raton, FL USA
1600 John F. Kennedy Blvd. Ste 1800
Philadelphia, PA19103-2899
HANDBOOK OF RETINAL OCT, SECOND EDITION 2022
ISBN: 978-0-323-75772-0
Notice
Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds or experiments described herein. Because of rapid advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made. To the fullest extent of the law, no responsibility is assumed by Elsevier, authors, editors or contributors for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.
Previous edition 2014
Library of Congress Control Number 2021939121
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Senior Content Development Specialist: Angie Breckon
Publishing Services Manager: Shereen Jameel
Senior Project Manager: Karthikeyan Murthy
Design Direction: Brian Salisbury
Printed in India
Last digit is the print number: 9 8 7 6 5 4 3 2 1
Eduardo
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Preface
Optical coherence tomography (OCT) was “discovered” in an optics lab at the Massachusetts Institute of Technology in the late 1980s by James Fujimoto and his collaborators: Carmen Puliafito, Joel Schuman, David Huang, Eric Swanson, and Mike Hee. It began as an effort to experimentally measure excimer laser corneal ablation in real time. While it failed in that regard, the founders quickly identified the possibility that OCT could be employed to measure static ocular tissue thickness in real time. The first publication on OCT was in Science in 1991, and by 1996 the technology was transferred to a commercial company, and soon thereafter commercial devices began to be sold.
It is safe to say that OCT is one of the most important ancillary tests in ophthalmology and is indisputably the most important ancillary test in the subspecialty of the retina. In the first edition, we set out to produce an easy-to-read, brief but complete handbook of OCT images that was disease-based. Given the importance of OCT in our practices, we concluded that the OCT images should be the major focus of the book. Consistency of chapter layout, excellent images, and well-documented pathologic features were all goals. We feel we succeeded.
The second edition carries on the format of minimal clinical description of the pathologic entities, as there are plenty of excellent textbooks that cover these entities in more depth. We have expanded the book to include a number of new pathological entities. In addition, we have added optical coherence tomography angiography (OCTA) where appropriate.
We hope you find this handbook useful in your clinical practice on a daily basis.
Jay S. Duker, MD
Nadia K. Waheed, MD, MPH
Darin R. Goldman, MD
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Omar Abu-Qamar, MD, MMSc
OCT Research Fellow
New England Eye Center
Tufts Medical Center
Tufts University School of Medicine
Boston, MA
USA
Eugenia Custo Greig, MD
Yale School of Medicine
New Haven, CT
USA
Daniela Ferrara, MD, MSc, PhD Assistant Professor of Ophthalmology
Tufts University School of Medicine
Boston, MA
USA
Darin R. Goldman, MD
Vitreo-retinal Surgeon
Partner, Retina Group of Florida
Clinical Affiliate Associate Professor of Surgery
Charles E. Schmidt College of Medicine
Florida Atlantic University
Boca Raton, FL
USA
Alessandro A. Jammal, MD
Research Scientist
Duke Eye Center
Duke University
Durham, NC
USA
Glaucoma Specialist
State University of Campinas
Campinas
Brazil
List of Contributors
Emily S. Levine, MD, MTM
Resident Physician in Ophthalmology
Dartmouth Hitchcock Medical Center
Lebanon, NH USA
Luísa S.M. Mendonça, MD Department of Ophthalmology
Federal University of São Paulo
São Paulo
Brazil
Alexandre S.C. Reis, MD, PhD Unicamp Opthalmology
Campinas
Brazil
Eduardo Uchiyama, MD
Uveitis Specialist
Vitreo-Retinal Surgeon Retina Group of Florida
Fort Lauderdale, FL
Affiliate Assistant Professor
Charles E. Schmidt College of Medicine
Florida Atlantic University
Boca Raton, FL
USA
Nadia K. Waheed, MD, MPH Professor in Ophthalmology
New England Eye Center
Tufts Medical Center
Tufts University School of Medicine
Boston, MA
USA
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The development of optical coherence tomography and its emergence as the most important ancillary test in ophthalmology is inextricably linked to the New England Eye Center at Tufts Medical Center and its physicians. The clinical experiences summarized in this book are based on the collective expertise gained at the Eye Center over the past three decades, and we are very grateful to our colleagues Caroline Baumal, Elias Reichel, Chris Robinson, Andre Witkin, Michelle Liang, and Shilpa Desai with whom we are privileged to share patients and who have been an inexhaustible resource for this endeavor.
We would also like to acknowledge the unparalleled ophthalmic imaging department at the New England Eye Center whose members acquired most of the images included in this book. Thanks also go out to the contributing authors and to our production team at Elsevier who worked on a very tight schedule to get the book published in just over six months. Our fellows and residents, whose questions provide constant intellectual challenge, also deserve acknowledgment. And last but perhaps most importantly, we would like to thank our families for their patience and support.
Dedications
To my wife, Julie, and my children, Jake, Bear, Sam, and Elly, whose support, love, patience, and understanding allow me to pursue projects like this book. Also, to Carmen Puliafito, Joel Schuman, and Jim Fujimoto—without them OCT would not exist and without their mentorship and collaboration I would never have become immersed in it.
Jay S. Duker
To Khadija and Ahmed, for their patience, generosity, support, and encouragement. To my mother, Khalida, the constant inspiration, who set and supported me on a path that few have the good fortune to follow. None of this would be possible without the three of you. To my dad, whose grace and good humor have always been an inspiration. To my mentors past and present, and to my co-authors who made the process of writing this book such a phenomenally enjoyable and educational experience.
Nadia K. Waheed
To my wife, Robin, whose constant love and encouragement allow me to pursue my many passions. To my children, Rona, Cole, and Lexi, who keep me grounded and on my toes. To my parents, Marisse and Tony, whose support I am forever grateful to have. Lastly, to my mentors, who paved the way ahead giving me a clear path to achieve my professional aspirations.
Darin R. Goldman
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