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Oxford Handbook for Medical School

Published and forthcoming Oxford Handbooks

Oxford Handbook for the Foundation Programme 4e

Oxford Handbook of Acute Medicine 3e

Oxford Handbook of Anaesthesia 4e

Oxford Handbook of Cardiology 2e

Oxford Handbook of Clinical and Healthcare Research

Oxford Handbook of Clinical and Laboratory Investigation 4e

Oxford Handbook of Clinical Dentistry 6e

Oxford Handbook of Clinical Diagnosis 3e

Oxford Handbook of Clinical Examination and Practical Skills 2e

Oxford Handbook of Clinical Haematology 4e

Oxford Handbook of Clinical Immunology and Allergy 3e

Oxford Handbook of Clinical Medicine – Mini Edition 9e

Oxford Handbook of Clinical Medicine 10e

Oxford Handbook of Clinical Pathology

Oxford Handbook of Clinical Pharmacy 3e

Oxford Handbook of Clinical Specialties 10e

Oxford Handbook of Clinical Surgery 4e

Oxford Handbook of Complementary Medicine

Oxford Handbook of Critical Care 3e

Oxford Handbook of Dental Patient Care

Oxford Handbook of Dialysis 4e

Oxford Handbook of Emergency Medicine 4e

Oxford Handbook of Endocrinology and Diabetes 3e

Oxford Handbook of ENT and Head and Neck Surgery 2e

Oxford Handbook of Epidemiology for Clinicians

Oxford Handbook of Expedition and Wilderness Medicine 2e

Oxford Handbook of Forensic Medicine

Oxford Handbook of Gastroenterology & Hepatology 2e

Oxford Handbook of General Practice 4e

Oxford Handbook of Genetics

Oxford Handbook of Genitourinary Medicine, HIV, and Sexual Health 2e

Oxford Handbook of Geriatric Medicine 3e

Oxford Handbook of Infectious Diseases and Microbiology 2e

Oxford Handbook of Integrated Dental Biosciences 2e

Oxford Handbook of Humanitarian Medicine

Oxford Handbook of Key Clinical Evidence 2e

Oxford Handbook of Medical Dermatology 2e

Oxford Handbook of Medical Imaging

Oxford Handbook of Medical Sciences 2e

Oxford Handbook for Medical School

Oxford Handbook of Medical Statistics

Oxford Handbook of Neonatology 2e

Oxford Handbook of Nephrology and Hypertension 2e

Oxford Handbook of Neurology 2e

Oxford Handbook of Nutrition and Dietetics 2e

Oxford Handbook of Obstetrics and Gynaecology 3e

Oxford Handbook of Occupational Health 2e

Oxford Handbook of Oncology 3e

Oxford Handbook of Operative Surgery 3e

Oxford Handbook of Ophthalmology 4e

Oxford Handbook of Oral and Maxillofacial Surgery 2e

Oxford Handbook of Orthopaedics and Trauma

Oxford Handbook of Paediatrics 2e

Oxford Handbook of Pain Management

Oxford Handbook of Palliative Care 3e

Oxford Handbook of Practical Drug Therapy 2e

Oxford Handbook of Pre-Hospital Care

Oxford Handbook of Psychiatry 3e

Oxford Handbook of Public Health Practice 3e

Oxford Handbook of Rehabilitation Medicine 3e

Oxford Handbook of Reproductive Medicine & Family Planning 2e

Oxford Handbook of Respiratory Medicine 3e

Oxford Handbook of Rheumatology 4e

Oxford Handbook of Sport and Exercise Medicine 2e

Handbook of Surgical Consent

Oxford Handbook of Tropical Medicine 4e

Oxford Handbook of Urology 4e

Oxford Handbook for Medical School

Editor-in-Chief

Kapil Sugand

Trauma and Orthopaedics Specialist Trainee and Surgical Research Fellow, Imperial College London, UK

Edited by Miriam Berry

Consultant Nephrologist, University Hospitals Birmingham, Birmingham, UK

Imran Yusuf

Ophthalmology Specialist Trainee and MRC Research Fellow, Oxford University, UK

Aisha Janjua

Obstetrics and Gynaecology Specialist Trainee and NIHR Clinical Lecturer, Warwick University, UK

Chris Bird

Consultant in Paediatric Emergency Medicine, Oxford, UK

Consultant Editors

David Metcalfe

Clinical Research Fellow in Musculoskeletal Trauma, Oxford University, UK

Harveer Dev

Urology Specialist Trainee and Wellcome Trust PhD Fellow, Cambridge University, UK

Sri Thrumurthy

General Surgical Specialist Trainee, University College London Hospitals, UK

1

Great Clarendon Street, Oxford, OX2 6DP, United Kingdom

Oxford University Press is a department of the University of Oxford. It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide. Oxford is a registered trade mark of Oxford University Press in the UK and in certain other countries

© Oxford University Press 2019

The moral rights of the authors have been asserted

First Edition published in 2019

Impression: 1

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, without the prior permission in writing of Oxford University Press, or as expressly permitted by law, by licence or under terms agreed with the appropriate reprographics rights organization. Enquiries concerning reproduction outside the scope of the above should be sent to the Rights Department, Oxford University Press, at the address above

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Published in the United States of America by Oxford University Press 198 Madison Avenue, New York, NY 10016, United States of America

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Library of Congress Control Number: 2018954692

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Links to third party websites are provided by Oxford in good faith and for information only. Oxford disclaims any responsibility for the materials contained in any third party website referenced in this work.

Dedication

We would like to wholeheartedly thank the following people for their constant support, efforts, and faith in us, in helping to realize this handbook after 7 years.

Sincere and heartfelt thanks to the following:

• The publishing team from Oxford University Press, especially Mr Michael Hawkes (Senior Assistant Commissioning Editor for Medical Books) for his patience, negotiation, and expertise. You have been there every step of the way and your efforts are very much appreciated.

• All members of the editorial team and the consultant reviewers for giving up so much of their personal time to assist the contributors and ensuring quality control of the content. Thank you for working so well as a team and bringing such superb ideas to the table.

• Our plethora of devoted contributors and educators from every field of medicine and surgery. Thank you for submitting work of such high calibre, your insights, and expert advice.

• Our colleague publishing houses for offering permission to use their images.

• Our internal reviewers for taking the time out to review, critique, and appraise our entire book and offering your constructive criticisms to improve the content.

• Our families for their love, encouragement, and motivation. Thank you for compromising and sacrificing quality time with us, once again, so that we could write this handbook for every medical student everywhere. Needless to say, we will be striving to make up for the lost time.

• Our international audience for wanting a book like this and supporting the project from the very beginning. This handbook has been written for you. We all hope that it will serve as a useful companion throughout your exciting time at medical school that will ultimately lay the strong foundations for a lifetime of clinical practice.

Foreword

This superb guide to the neophyte doctor ranges from one’s first approach to medical school and how to cope with such a complex process right through to a doctor’s decision on which specialty career to follow eventually. As always this Oxford Handbook covers a vast range of useful, relevant material, and this particular one will be of great value to anyone seriously considering medical school for their future career choice.

The contributors are a talented group of doctors whose expertise and interests span many different clinical specialties as well as having, between them, a vast experience in clinical academic research as well as a huge commitment in the modern complex process of medical education.

I am sure this book, where the nuts and bolts of virtually every specialty are most clearly laid out, will be a most useful guide worldwide for those not only considering a career in the medical profession but even those midway through their medical careers.

Peter Abrahams MBBS FRCS(ED) FRCR DO(Hon) FHEA

Prof. Emeritus of Clinical Anatomy

Warwick Medical School, Gibbet Hill National Teaching fellow 2011–14

Life fellow, Girton college, Cambridge

Visiting Professor LKC School of Medicine NTU Singapore

Preface

Medicine is a huge undertaking, both to study as an undergraduate and subsequently to practise as a doctor. During your preclinical studies, you are expected to learn anatomy, physiology, and biochemistry but also genetics, pharmacology, pathology, microbiology, the history of medicine, psychology, sociology, law, ethics, epidemiology, and statistics. The list is neverending! These are vast disciplines in their own right and medical students often struggle to understand what exactly they are expected to learn. The course objectives are frequently vague: ‘students should be able to identify the important anatomical structures of the pelvis and lower limbs’. You are also bound to see a course handbook state: ‘students may be assessed on any material from the lectures, group work, recommended reading, and anything else that the examiners feel students should know at this stage’. A common complaint of all medical students is that the material tested in exams feels disconnected from the topics taught. This is very different from the situation at secondary school in which core knowledge is tightly defined by a course syllabus. You would not be alone in becoming frustrated by the seemingly unpredictable, if not unlimited bounds of knowledge that appear to be expected by examiners.

Furthermore, the clinical years bring their own particular challenges. You are thrust into unfamiliar environments in which busy and overworked staff are trying to manage complex tasks with little time set aside to teach students, due to constant understaffing and lack of resources. The material that you painstakingly learned during the preclinical years somehow seems irrelevant to—or at least wholly insufficient to understand—what is going on in a practical and clinical setting. There are hierarchies, conflicts, and unwritten rules that you will navigate with varying degrees of success. You will never quite overcome the feeling of always being ‘in the way’. The overwhelming burden of boundless learning returns as you wrangle with over 60 different branches of medicine and surgery, from anaesthetics to urology. The knowledge expected of you by a cardiologist in a heart failure clinic will differ wildly to that expected by a skull base neurosurgeon in the operating theatre.

Hence, this handbook was conceived as a partial solution to the complexities of learning medicine in the twenty-first century. Sir William Osler famously wrote, ‘he who studies medicine without books sails an uncharted sea’. This handbook should serve as your map through the countless obstacles that you must overcome on your journey to qualifying as a doctor. First, it will help define the core knowledge that is expected of all medical students, which is often distinct from the niche interests of individual teachers. Second, it will identify ‘high-yield’ information and suggest what you should know (and so are likely to be asked) in any given clinical setting. Besides serving as a quick reference guide, this handbook introduces core topics to help guide you with further reading in your own time. It will also help you to prepare for some of the unfamiliar settings (such as etiquette

and conduct in the operating theatre, on wards, and in the emergency department) where you are likely to find yourself over the next few years until retirement.

The Oxford Handbook for Medical School will provide you with succinct, precise, and accurate facts about medicine and surgery that are bound to come up on a daily basis whether in or out of your time in hospital. The core motivation was to bequeath all the important lessons about the medical course and subject matter to the next generation of NHS leaders, pioneers, and consultants as well as to reflect on what we would like to have known back when we were medical students. Whether you are in the cardiology clinic, on the surgical wards, in theatre, or witnessing emergency care, this handbook includes carefully selected clinical scenarios that will explain the logic behind the management plans as well as improve your confidence in explaining it to your examiners. With aide-memoires, mnemonics, pictures, and seminal research accompanied by concise text you will be able to easily deconstruct abstract principles into digestible and memorable information. Since medical school is not only about clinical attachment as it encroaches into your personal life too, there is plenty of useful information on managing finances, health issues, planning electives, and career guidance to improve your chances of professional success from an early stage. Not many other books, at least known to us, can say the same. We have also ensured that the handbook does not preach or lecture but communicates with its audience on an informal and conversational level.

Needless to say, writing this compendium has been one of the biggest professional challenges to the editorial team but if it means that we manage to improve the quality of medical education globally, uplift the competence of medical students in all corners of the world, and give you another reason to fall in love with this vocation, then all the personal sacrifices, compromises, and struggles will have been all the more worthwhile. Medicine is obviously voluminous and it is sometimes discouraging when the sudden realization dawns on you that there is much work to be done in order to carry out the responsibilities for your vulnerable patients. Hopefully the Oxford Handbook for Medical School will serve as a friendly companion to ease your stress throughout your studies as well as introduce you to other speciality-specific Oxford Handbooks for further information with our cross-referencing style.

The Oxford Handbook for Medical School is the result of efforts from eight doctors from a range of specialities to offer a one-stop survival guide for every medical student to make the most of their course from the very first day to the very last. There was a vision and intention to pose the commonest clinical scenarios, how to excel at medical school, and improve career potential early on. There are clearly many textbooks available on the market with too little or too much information, written formally as if you were being lectured, and with dense data that risk losing your attention. This survival guide synthesizes advice from over 100 doctors. It has been said that ‘you should learn from the mistakes of others as you do not have time to make them all yourself’. The time you spend reading this handbook could well be one of the best investments you make at medical school.

Finally, on behalf of the editorial team, we would like to take this opportunity to wholeheartedly thank everyone involved in the success of this handbook. We welcome your feedback to constantly improve the content of this handbook in subsequent editions and we hope that the Oxford Handbook for Medical School will serve you well.

David Metcalfe and Kapil Sugand Members of the Editorial Team Oxford Handbook for Medical School May 2018

Contributors

John R. Apps

(Chapter 54: Getting ahead)

Paediatric Specialist Oncology Trainee, Birmingham Women’s and Children’s NHS Foundation Trust. Birmingham, UK, Honorary Research Associate, UCL Great Ormond Street Institute of Child Health, University College London, London, UK

Bilal Azhar (Chapter 42: Upper gastrointestinal and hepatopancreatobiliary surgery)

Vascular Surgery Specialist Registrar, London Deanery, London Postgraduate School of Surgery, UK

James R. Bentham (Chapter 26: Paediatrics)

Assistant Professor and Consultant Paediatric and Adult Interventional Cardiologist, Department of Paediatric Cardiology, Leeds General Infirmary, UK

Miriam Berry

(Chapter 3: Preclinical medicine; Chapter 5: Intercalated degrees and special study modules; Chapter 21: Nephrology; Chapter 48: Clinical assessments; Chapter 50: Clinical examinations; Chapter 54: Getting ahead)

Consultant Nephrologist, University Hospitals Birmingham, Birmingham, UK

Chris Bird (Chapter 3: Preclinical medicine; Chapter 6: Going clinical; Chapter 26: Paediatrics; Chapter 45: Practical procedures; Chapter 46: Basic investigations) Consultant in Emergency Paediatric Medicine, Birmingham Children’s Hospital, UK

Lesley Black (Chapter 17: Genitourinary medicine)

GP Specialist Registrar, Severn Deanery, Bristol, UK

Deborah Bowman (Chapter 47: Ethics and law) Professor of Bioethics, Clinical Ethics and Medical Law at St George’s, University of London, UK

Lois Brand (Chapter 53: Making decisions) Consultant in Emergency Medicine, John Radcliffe Hospital, Oxford, UK

Elsa Butrous (Chapter 54: Getting ahead)

GP Specialist Registrar, Oxford Deanery, UK

James Butterworth (Chapter 34: Colorectal surgery) Surgical Specialist Registrar, Clinical Research Fellow, Department of Cancer and Surgery, Imperial College London, London, UK

William Butterworth (Chapter 34: Colorectal surgery)

Core Surgical Trainee, General Surgery, Princess Royal University Hospital, London, UK

Nandini Datta

(Chapter 6: Going clinical)

Senior Resident Medical Officer, Emergency Department, Gosford Hospital, Central Coast Local Health District, Australia

Fungai Dengu (Chapter 42: Upper gastrointestinal and hepatopancreatobiliary surgery)

ST5 General Surgery Registrar

Oxford Deanery, Clinical Research Fellow in Transplant Surgery, Nuffield Department of Surgical Sciences, University of Oxford.

Harveer Dev

(Chapter 3: Preclinical medicine; Chapter 8: Cardiology; Chapter 41: Vascular surgery; Chapter 43: Urology)

Urology Specialist Trainee and Wellcome Trust PhD Fellow, Cambridge University Hospitals NHS Trust, UK

Kate Drysdale (Chapter 14: Gastroenterology)

Hepatology Clinical Research Fellow, Queen Mary University of London, London, UK

Tegwen Ecclestone

(Chapter 56: Career planning)

Core Trainee, Northern Deanery, UK

Daniel Fitzgerald (Chapter 56: Career planning)

Medical Doctor, Médecins Sans Frontières, Operational Centre Paris, France

Neil Gupta (Chapter 44: Radiology)

Consultant Interventional Radiologist, Joint College Tutor for Clinical Radiology, Radiology Fellowship Program Director, University Hospital Coventry & Warwickshire, Coventry, UK

Ruofan Connie Han (Chapter 49: Preparing for clinical examinations)

Specialist Registrar in Ophthalmology, Oxford Eye Hospital, John Radcliffe Hospital, UK

Adam Handel (Chapter 50: Clinical examinations)

Clinical Lecturer in Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford

Ayad Harb (Chapter 39: Plastic surgery)

Consultant Plastic Surgeon, University Hospital North Midlands NHS Trust, UK

Amy Hawkins (Chapter 55: Electives)

Specialist Registrar in Palliative Medicine, London, UK

Fiona Hayes (Chapter 31: Rheumatology) Consultant in Rheumatology and Acute Medicine Southend University Hospital NHS Trust, UK

Catherine Hearnshaw (Chapter 50: Clinical examinations)

Specialist Registrar Paediatrics, Royal Derby Hospital, UK

Alexander J Hills

(Chapter 37: Oral and maxillofacial surgery)

Specialist Registrar, Oral and Maxillofacial Surgery, Queen Victoria Hospital, East Grinstead, Sussex, UK

Thiagarajan Jaiganesh

(Chapter 12: Emergency medicine)

Consultant in Adult and Paediatric Emergency Medicine, Emergency Department, St George’s, University of London, UK

Aisha Janjua

(Chapter 23: Obstetrics & Gynaecology

Chapter 50: Clinical examinations; Chapter 51: Written exams)

Obstetrics and Gynaecology

Specialist Registrar and NIHR Clinical Lecturer, Warwick University, UK

Mhairi Jhugursing

(Chapter 9: Critical care)

Consultant Anaesthetist, West Middlesex Hospital, London, UK

Irfan Jumabhoy

(Chapter 2: Studying at medical school; Chapter 54: Getting ahead)

Core Surgical Trainee, Plastic and Reconstructive Surgery, Nottingham University Hospital NHS Trust, Nottingham, UK

Raghunath Kadiyala

(Chapter 13: Endocrinology and diabetes)

Consultant in Diabetes and Endocrinology, Stoke Mandeville Hospital, Buckinghamshire

Healthcare NHS Trust, Aylesbury, UK

Sheirin Khalil

(Chapter 52: Other assessments)

GP Specialist Registrar, James Paget University Hospital, Great Yarmouth, UK

Harry Krishnan (Chapter 50: Clinical examinations)

Specialist Trainee, Trauma and Orthopaedics, Northwest Thames Rotation, UK

Kar-Hung Kuet (Chapter 10: Dermatology)

Specialist Registrar, Dermatology, Royal Hallamshire Hospital, Sheffield, UK

Mong -Loon Kuet

(Chapter 35: Ear, nose, and throat surgery)

Specialist Registrar, Ipswich Hospital NHS Trust, Ipswich, UK

Suhas S. Kumar (Chapter 7: Anaesthetics)

Consultant, Department of Anaesthesia and Critical Care, Norfolk and Norwich University Hospital, Norwich, UK

Lily XLi

(Chapter 40: Trauma and orthopaedic surgery)

Orthopaedic Specialist Registrar, North West London rotation, UK

Firas Maghrabi (Chapter 20: Infectious diseases and tropical medicine)

Clinical Research Fellow in Infectious Diseases, The National Aspergillosis Centre, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, UK

David Metcalfe

(Chapter 8: Cardiology; Chapter 30: Respiratory medicine; Chapter 41: Vascular surgery)

Clinical Research Fellow in Musculoskeletal Trauma, University of Oxford, UK

Yasmeen Mulla

(Chapter 4: Preparing for preclinical exams)

GP Specialty Trainee, Thames Valley Deanery, Buckinghamshire Healthcare Trust, UK

Biplab Nandi

(Chapter 38: Paediatric surgery)

Lecturer in Paediatric Surgery, College of Medicine, University of Malawi; Consultant Paediatric Surgeon, Kamuzu Central Hospital, Lilongwe, Malawi

Fiona Napier

(Chapter 3: Preclinical medicine; Chapter 7: Anaesthetics; Chapter 13: Endocrinology and diabetes; Chapter 14: Gastroenterology; Chapter 21: Nephrology; Chapter 22: Neurology)

Consultant, Emergency Department, Derriford Hospital, Plymouth, UK

Arjun Odedra

(Chapter 5: Intercalated degrees and special study modules; Chapter 54: Getting ahead)

GP Specialist Registrar, Royal Surrey County Hospital, Guildford, UK

Nicola Okeahialam

(Chapter 6: Going clinical)

Specialist Registrar, Obstetrics and Gynaecology, Chelsea & Westminster Hospital, London, UK

Vishal Patel (Chapter 32: Breast surgery)

Breast and General

Surgery Specialist Registrar, North West London Deanery, UK

Nikhil Pawa

(Chapter 34: Colorectal surgery)

Consultant General & Colorectal Surgeon, West Middlesex University Hospital Middlesex, UK

Benjamin Pinkey

(Chapter 6: Going clinical) Consultant Paediatric

Radiologist, Department of Radiology, Birmingham Children’s Hospital, Birmingham Women’s and Children’s NHS Foundation Trust, UK

Emma Prower (Chapter 11: Elderly care)

Intensive Care Specialist Registrar, Kings College Hospital, London, UK

Tasneem Rahman (Chapter 19: Immunology and allergies)

Specialist Registrar in Immunology and Allergy, Department of Immunopathology, Royal London Hospital, London, UK

Fatimah Ravat (Chapter 2: Studying at medical school)

Postgraduate MSc Student, Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh, UK

Imran Raza

(Chapter 34: Colorectal surgery)

Specialist Registrar in Colorectal and general surgery, University College Hospital, London, UK

Isabel Rodriguez-Goncer (Chapter 20: Infectious diseases and tropical medicine)

Senior Clinical Fellow in Infectious Diseases, The National Aspergillosis Centre, Manchester University NHS Foundation Trust, Wythenshawe hospital, Manchester, UK

Shahbaz Roshanzamir (Chapter 11: Elderly care)

Consultant Geriatrician and General Physician, Department of Ageing and Health, Guy’s & St Thomas’ Hospital, London, UK

Hazim Sadideen

(Chapter 39: Plastic surgery)

Department of Surgery and Cancer, Imperial College London, London, UK

Ahmed-Ramadan Sadek (Chapter 36: Neurosurgery)

Senior Neurosurgical Registrar, Jason Brice Fellow in Neurosurgical Research, Department of Neurosurgery, Wessex Neurological Centre, University Hospital Southampton, UK

Ashraf Sanduka (Chapter 28: Pathology)

Consultant, Department of Histopathology, West Suffolk Hospital, Bury St Edmunds, Suffolk, UK

Guy Schofield (Chapter 27: Palliative medicine)

Specialist Registrar in Palliative Medicine, Wellcome Trust Society and Ethics Fellow, Centre for Ethics in Medicine, University of Bristol, UK

Katherine Schon (Chapter 16: Genetics)

Specialist Registrar and Academic Clinical Fellow, Department of Clinical Genetics, East Anglian Medical Genetics Service, Addenbrooke’s Hospital, Cambridge, UK

Eshan Senanayake (Chapter 33: Cardiothoracic surgery)

Specialist Registrar, Department of Cardiothoracic Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

Stephanie Slater (Chapter 51: Written exams)

Senior House Officer, Acute Medicine, Croydon University Hospital, UK

Carmel Stober (Chapter 31: Rheumatology)

Locum Consultant in Rheumatology, Department of Rheumatology, Cambridge University Hospitals

NHS Foundation Trust, Addenbrooke’s Hospital, Cambridge, UK

Amit Sud

(Chapter 18: Haematology)

Clinical Research Fellow, The Institute of Cancer Research/ The Royal Marsden NHS Foundation Trust, London, UK

Kapil Sugand

(Chapter 1: Starting as a medical student; Chapter 3: Preclinical medicine; Chapter 5: Intercalated degrees and special study modules; Chapter 8: Cardiology; Chapter 12: Emergency medicine; Chapter 15: General practice; Chapter 30: Respiratory medicine; Chapter 34: Colorectal surgery; Chapter 40: Trauma and Orthopaedics; Chapter 41: Vascular surgery; Chapter 43: Urology; Chapter 49: Preparing for clinical examinations; Chapter 50: Clinical examinations; Chapter 53: Making decisions; Chapter 54: Getting ahead)

Editor-in-Chief for OHMS, Trauma and Orthopaedics

Specialist Registrar and Surgical Research Fellow, Imperial College London, UK,

Quen Tang

(Chapter 40: Trauma and orthopaedic surgery)

Specialist Registrar in Trauma and Orthopaedics, North West Thames Rotation, Department of Trauma and Orthopaedics, Chelsea and Westminster Hospital, London, UK

Hannah Tharmalingam

(Chapter 24: Oncology)

Oncology Registrar, Department of Oncology, Mount Vernon Cancer Centre, Northwood, UK

Jemma Theivendran (Chapter 29: Psychiatry)

Specialist Registrar in Child and Adolescent Psychiatry, South West London and St George’s Mental Health Trust; Honorary Clinical Lecturer, St George’s, University of London, UK

Sri Thrumurthy (Chapter 8: Cardiology; Chapter 30: Respiratory medicine; Chapter 41: Vascular surgery)

General Surgical Specialist Trainee, University College London Hospitals NHS Trusts, UK

Alex Tsui (Chapter 22: Neurology)

Specialist Registrar, Clinical Research Fellow, MRC Unit for Lifelong Health and Ageing, University College London, UK

Aravinthan Varatharaj (Chapter 22: Neurology)

MRC Clinical Research Training Fellow, University of Southampton, and Honorary Specialist Registrar in Neurology, Wessex Neurological Centre, UK

Laura Watson  (Chapter 15: General practice)

GP, Emergency Department, John Radcliffe Hospital, Oxford

(Chapter 1: Starting as a medical student; Chapter 2: Studying at medical school;

Chapter 6: Going clinical; Chapter 25: Ophthalmology; Chapter 50: Clinical examinations; Chapter 56: Career planning)

Ophthalmology Specialist

Registrar and MRC Research Fellow, Oxford University, UK

Symbols and abbreviations

approximately

cross-reference

d decreased

i increased

l leading to

n normal

M website

± with or without

2D two-dimensional

3D three-dimensional

5HT 5-hydroxytryptamine (serotonin)

AAA abdominal aortic aneurysm

AAGBI Association of Anaesthetists of Great Britain and Ireland

ABG arterial blood gas

ACEI angiotensin-converting enzyme inhibitor

ACJ acromioclavicular joint

ACL anterior cruciate ligament

ACR albumin:creatinine ratio

ACS acute coronary syndrome

ACTH adrenocorticotropic hormone

ADP adenosine diphosphate

ADPKD autosomal dominant polycystic kidney disease

AF atrial fibrillation

AFP Academic Foundation Programme

AIDS acquired immunodeficiency syndrome

AKI acute kidney injury

ALF Access to Learning Fund

ALP alkaline phosphatase

ALS advanced life support

AMD age-related macular degeneration

ANA antinuclear antibody

AP anteroposterior

APTT activated partial thromboplastin time

ARB angiotensin receptor blocker

ARDS acute respiratory distress syndrome

AS aortic stenosis or ankylosing spondylitis

ASA aminosalicylic acid

aSAH aneurysmal subarachnoid haemorrhage

ASCT allogenic stem cell transplant

ASIS anterior superior iliac spine

AST aspartate transaminase

ATLS® Advanced Trauma Life Support®

ATN acute tubular necrosis

AV atrioventricular

AXR abdominal X-ray

BAL bronchoalveolar lavage

BCC basal cell carcinoma

BCG bacillus Calmette–Guérin

BMA British Medical Association

BMedSci Bachelor in Medical Sciences

BMI body mass index

BNF British National Formulary

BNFC British National Formulary for Children

BNP B-type natriuretic peptide

BP blood pressure

BPH benign prostatic hyperplasia

bpm beats per minute

BPPV benign paroxysmal positional vertigo

BSc Bachelor of Science

BTS British Thoracic Society

CABG coronary artery bypass graft

CBD common bile duct

CBT cognitive behavioural therapy

CCT certificate of completion of training

CD Crohn’s disease

CGA comprehensive geriatric assessment

CHD congenital heart disease

CJD Creutzfeldt–Jakob disease

CK creatine kinase

CMV Cytomegalovirus

CNS central nervous system

CO cardiac output

COPD chronic obstructive pulmonary disease

COX cyclooxygenase

CPAP continuous positive airway pressure

CPR cardiopulmonary resuscitation

SYMBOLS AND ABBREVIATIONS

CRB Criminal Record Bureau

CREST calcinosis, Raynaud’s phenomenon, (o)esophageal dysmotility, sclerodactyly, and telangiectasia

CRP C-reactive protein

CS caesarean section

CSF cerebrospinal fluid

C-spine cervical spine

CT computed tomography

CTPA computed tomography pulmonary angiogram

CV curriculum vitae

CVA cerebrovascular accident

CVC central venous catheter

CVP central venous pressure

CVS cardiovascular system

CXR chest X-ray

D&V diarrhoea and vomiting

DC direct current

DHx drug history

DIC disseminated intravascular coagulation

DIPJ distal interphalangeal joint

DKA diabetic ketoacidosis

DM diabetes mellitus

DMARD disease-modifying anti-rheumatoid drug

DPhil Doctor of Philosophy

DRE digital rectal examination

DSM Diagnostic and Statistical Manual of Mental Disorders

DTaP diphtheria, tetanus, and pertussis

DVLA Driver and Vehicle Licensing Agency

DVT deep vein thrombosis

EBV Epstein–Barr virus

ECG electrocardiography/electrocardiogram

ED emergency department

EEG electroencephalography/electroencephalogram

ELISA enzyme-linked immunosorbent assay

EMQ extended matching question

EPO erythropoietin

ERCP endoscopic retrograde cholangiopancreatography

ERV expiratory reserve volume

ESR erythrocyte sedimentation rate

ETOH alcohol

ETT endotracheal tube

EUS endoscopic ultrasound

EVAR endovascular aneurysm repair

FACS fluorescence-activated cell sorting

FBC full blood count

FEV1 forced expiratory volume in 1 sec

FHx family history

FISH fluorescent in situ hybridization

FNA fine-needle aspiration

FNAC fine-needle aspiration cytology

FRC functional residual capacity

FVC forced vital capacity

FY1 Foundation Year 1

G6PD glucose-6-phosphate dehydrogenase

GA general anaesthesia

GC gonorrhoea

GCA giant cell arteritis

GCP Good Clinical Practice

GCS Glasgow coma scale

GHJ glenohumeral joint

GI gastrointestinal

GMC General Medical Council

GORD gastro-oesophageal reflux disease

GP general practitioner

GTN glyceryl trinitrate

GUM genitourinary medicine

HAART highly active antiretroviral therapy

Hb haemoglobin

HbA1c glycated haemoglobin

hCG human chorionic gonadotropin

HD Huntington disease

HDU high dependency unit

HiB Haemophilus influenza type B

HIV human immunodeficiency virus

HL Hodgkin lymphoma

HNPCC hereditary non-polyposis colorectal cancer

HPB hepatopancreatobiliary

HPC history of presenting complaint

HPV human papilloma virus

HR heart rate

SYMBOLS AND ABBREVIATIONS

HSV herpes simplex virus

IBD inflammatory bowel disease

IC inspiratory capacity

ICD International Classification of Diseases

ICE ideas, concerns, and expectations

ICP intracranial pressure

Ig immunoglobulin

IHD ischaemic heart disease

IM intramuscular

IMA inferior mesenteric artery

INR international normalized ratio

IOL intraocular lens

IPJ interphalangeal joint

IPPA inspection, palpation, percussion, and auscultation

IPV inactivated polio vaccine

IRV inspiratory reserve volume

ITU intensive therapy unit

IV intravenous

IVDU intravenous drug user

IVF in vitro fertilization

JVP jugular venous pressure

KUB kidneys, ureters, and bladder

LCL lateral collateral ligament

LDH lactate dehydrogenase

LFT liver function test

LIF left iliac fossa

LMA laryngeal mask airway

LMP last menstrual period

LMWH low-molecular-weight heparin

LP lumbar puncture

LRTI lower respiratory tract infection

LUQ left upper quadrant

LV left ventricular

MAP mean arterial pressure

MC&S microscopy, culture, and sensitivity

mcg microgram

MCL medial collateral ligament

MCPJ metacarpophalangeal joint

MCQ multiple-choice question

MCV mean corpuscular volume

MDDUS Medical Doctors and Dentists Defence Union of Scotland

MDT multidisciplinary team

MDU Medical Defence Union

MEN multiple endocrine neoplasia

MHC major histocompatibility complex

MI myocardial infarction

MMR measles, mumps, and rubella

MMSE Mini–Mental State Examination

MoCA Montreal Cognitive Assessment

MPS Medical Protection Society

MR mitral regurgitation

MRC Medical Research Council

MRCP magnetic resonance cholangiopancreatography

MRI magnetic resonance imaging

MS multiple sclerosis

MSk musculoskeletal

MSU midstream specimen of urine

MTPJ metatarsophalangeal joint

MV mitral valve

N&V nausea and vomiting

NAFLD non-alcoholic fatty liver disease

NAI non-accidental injury

NASH non-alcoholic steatohepatitis

NF1 neurofibromatosis type 1

NG nasogastric

NHL non-Hodgkin lymphoma

NHS National Health Service

NICE National Institute for Health and Care Excellence

NIHSS National Institutes of Health Stroke Scale

NIV non-invasive ventilation

NSAID non-steroidal anti-inflammatory drug

NSTEMI non-ST elevation myocardial infarction

O&G obstetrics and gynaecology

OA osteoarthritis

OGD oesophagogastroduodenoscopy

OGTT oral glucose tolerance test

OHFP2 Oxford Handbook for the Foundation Programme, second edition

OMFS oral and maxillofacial surgery

OSCE objective structured clinical examination

SYMBOLS AND ABBREVIATIONS

PA posteroanterior

PBC primary biliary cholangitis

PBL problem-based learning

PC presenting complaint

PCA patient-controlled analgesia

PCI percutaneous coronary intervention

PCL posterior cruciate ligament

PCOS polycystic ovarian syndrome

PCR polymerase chain reaction

PE pulmonary embolism

PEFR peak expiratory flow rate

PEP post-exposure prophylaxis

PET positron emission tomography

PhD Doctor of Philosophy

PICC peripherally inserted central catheter

PID pelvic inflammatory disease

PIPJ proximal interphalangeal joint

PMHx past medical history

PMR polymyalgia rheumatica

PNS peripheral nervous system

PO orally

PPI proton pump inhibitor

PR per rectum (rectally)

PSA prescribing skills assessment

PSC primary sclerosing cholangitis

PTH parathyroid hormone

PV per vaginam (vaginally)

PVD peripheral vascular disease

RA rheumatoid arthritis

RAPD relative afferent pupillary defect

RAS renin–angiotensin system

RBC red blood cell

Rh rhesus

RIF right iliac fossa

ROM range of movement

RRT renal replacement therapy

RSM Royal Society of Medicine

RTC road traffic collision

RUQ right upper quadrant

RV residual volume

SAH subarachnoid haemorrhage

SAQ short answer question

SBA single best answer

SC subcutaneously

SCC squamous cell carcinoma

SCJ sternoclavicular joint

SDH subdural haematoma

SHO senior house officer

SHx social history

SIADH syndrome of inappropriate antidiuretic hormone secretion

SIRS systemic inflammatory response syndrome

SJS Stevens–Johnson syndrome

SJT situational judgement test

SLE systemic lupus erythematosus

SMA superior mesenteric artery

SOB shortness of breath

SSc systemic sclerosis

SSM special study module

SSRI selective serotonin reuptake inhibitor

stat immediately

STEMI ST elevation myocardial infarction

STI sexually transmitted infection

STJ scapulothoracic joint

SVC superior vena cava

SVT supraventricular tachycardia

T3 triiodothyronine

T4 thyroxine

TB tuberculosis

TBI traumatic brain injury

TCA tricyclic antidepressant

TEN toxic epidermal necrolysis

TIA transient ischaemic attack

TLC total lung capacity

TLS tumour lysis syndrome

TNF tumour necrosis factor

TOE transoesophageal echocardiography

TSH thyroid-stimulating hormone

TTE transthoracic echocardiography

TURP transurethral resection of the prostate

TV tidal volume SYMBOLS AND ABBREVIATIONS

TVF tactile vocal fremitus

U&E urea and electrolytes

UC ulcerative colitis

UGI upper gastrointestinal

URTI upper respiratory tract infection

US ultrasound or United States

UTI urinary tract infection

V/Q ventilation/perfusion

VC vital capacity

VEGF vascular endothelial growth factor

VF ventricular fibrillation

VSD ventricular septal defect

VT ventricular tachycardia

VTE venous thromboembolism

WCC white cell count

WHO World Health Organization

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