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4.

5.

9.

Joseph J. Disa and Colleen M. McCarthy

10. Principles of Spine Imaging in Cancer

eric Lis and Christopher Mazzone

11.

Jon Lewis and George Krol

12. Cancer Statistics

Melissa M. Center and Ahmedin Jemal II

13.

14.

Heather L. McArthur and Clifford A. Hudis

Alexei Morozov and Susan F. Slovin

15. Evaluation and Treatment of Lung and Bronchus Cancer

Jorge e. Gomez

16. Evaluation and Treatment of Colorectal Cancer

Leonard B. Saltz and Austin G. Duffy

17. Evaluation and Treatment of Melanoma

Jedd D. Wolchok and Yvonne Saenger

18. Evaluation and Treatment of Lymphoma

enrica Marchi, Jasmine Zain, and Owen A. O’Connor

19.

Heather J. Landau and Stephen D. nimer

20. Evaluation and Treatment of Primary Central Nervous System Tumors

Sean A. Grimm and Lisa M. DeAngelis

21. Evaluation and Treatment of Gynecologic Cancer

Meena J. Palayekar and Dennis S. Chi

22.

23.

24.

25.

Laura Locati, Su Hsien Lim, Snehal Patel, and David G. Pfister

Robert Michael Tuttle and Rebecca Leboeuf

Robert G. Maki

Gary C. O’Toole and Patrick J. Boland

26.

Matthew n. Bartels and Megan L. Freeland

Matthew n. Bartels and Marsha Leight

28. Gastrointestinal

James Han, Rebecca G. Smith, Kevin Fox, and Argyrios Stampas

29.

30.

Michelle

32.

Argyrios Stampas, Rebecca G. Smith, Annelise Savodnik, and Kevin Fox

33.

34.

Julie Lin and Amanda Molnar

edward J. Dropcho

IV PAIN IN CANCER

neel Mehta, Amit Mehta, and Amitabh Gulati 39.

40.

42.

Barrie Cassileth, Robin C. Hindery, and Jyothirmai Gubili

NEUROLOGIC AND NEUROMUSCULAR COMPLICATIONS OF

43.

Michael

44.

48.

Louis H. Weimer and Thomas H. Brannagan

edward K. Avila and Sonia K. Sandhu

Justin C. Riutta

56.

Robert W. DePompolo, Julia F. Boysen, Mary J. Scherbring, and David Martin Strick

57.

58.

59.

60.

Lynn H. Gerber and Amanda Molnar

Azeez Farooki and Hanna Chua Rimner

Gary C. O’Toole, Patrick J. Boland, and Maryann Herklotz

63.

65.

Sharlynn M.

69.

70.

71.

Jimmie C. Holland, Talia R.

and Jessica

David William Pruitt and Rajaram nagarajan

Taryn Y. Lee and Sandy B. Ganz

Desiree A. Pardi, Golda B. Widawski, Dory Hottensen, and elizabeth Schack

Barrie R. Cassileth, Robin C. Hindery, and Jyothirmai Gubili

72. Balance and Gait Dysfunction in the Cancer Patient

elizabeth M. Kilgore and Cynthia G. Pineda

73. Cancer-Related Fatigue

Debora Julie Franklin and Lora Packel

74. Communication and Swallowing Dysfunction in the Cancer Patient

Margaret L. Ho

75. Bladder Dysfunction in the Cancer Patient

Todd A. Linsenmeyer and Georgi Guruli

76. Bowel Dysfunction in the Cancer Patient

Susan V. Garstang

77. Cognitive Dysfunction in the Cancer Patient

Tracy L. Veramonti and Christina A. Meyers

78. Activities of Daily Living in the Cancer Patient

Claudine Levy Campbell and Mackenzi Pergolotti

79. Lymphedema in the Cancer Patient

David Martin Strick and Gail Louise Gamble

SPECIAL TOPICS IN CANCER REHAbILITATION

80.

82.

Victoria Blinder and Madhu Mazumdar

83. Health Maintenance and Screening in Cancer Survivors

Kevin C. Oeffinger

Foreword

This textbook represents a milestone.

Dr. Howard Rusk, founder of the Rusk Institute of Rehabilitation Medicine, suggested that we needed a “service station” for cancer patients when he spoke at the first Cancer Conference on Rehabilitation Medicine in 1965 (1). In other words, a place where the multiple needs of cancer patients might be met. I credit him with the recognition that the cancer patient is a significant challenge to the health care establishment and would likely best be served in a comprehensive service organization. Others suggested that interdisciplinary efforts from the medical community, the patients, and the public sector would be needed to “reverse the defeatist attitude toward cancer and provide total continuity of care for the patient and for his family and community as well” (2).

Progress toward realizing Dr. Rusk’s recommendations has been very slow. I would offer that we are still not fully there.

Several elements are needed to achieve optimal care for cancer patients. These include their rehabilitation, which makes this textbook an important contribution to the lives of cancer survivors. Cancer survivors and their families are just beginning to articulate their concerns and several priorities have been identified: the need to provide continuity of care, recognizing that care requires a team approach; the importance of quality of life as a desired outcome of treatment; and the

recognition that independence in daily function is a high priority for many cancer survivors.

The field of rehabilitation of the cancer patient received a tremendous boost from the work of Dr. J. Herbert Dietz, Jr., who worked at the Institute of Rehabilitation Medicine, New York University Hospital, and Memorial Hospital for Cancer and Allied Diseases. Dr. Dietz published the first text on rehabilitation for the cancer patient, Rehabilitation Oncology, in 1981 (3). This text was organized with the rehabilitation model in mind, including evaluations of impairments, disability, and societal integration (handicap). He approached the patient from the perspective of treatment goals, including extensive patient and family education (preventive, restorative, supportive, and palliative), and the phase of cancer (preoperative, postoperative, convalescence, and posthospital). He recommended the application of solid methodology in evaluating patients and assessing efficacy of treatment. The aim of treatment was goal-oriented and often vocational. The impact of Dietz’s book on the next generation of oncological rehabilitation specialists was significant. In fact, in my own professional experience, it became clear to me that even without being conscious of it, Dr. Dietz’s approach guided my approach to treating patients. He also offered an evaluation tool, the Dietz Scale, which became a commonly used evaluation tool for use with cancer patients.

Lehmann and colleagues (4) published a remarkable manuscript identifying the needs of patients with cancer diagnoses. They demonstrated that cancer

patients had problems with self-care, mobility, and so on, and were likely to have psychological dysfunction and needed psychological support. They described the kinds of services required and valued by this population and demonstrated that when comprehensive rehabilitation was provided, there was significant clinical improvement. The authors concluded that patients with cancer need comprehensive rehabilitation, that if problems were properly identified and appropriate referrals were made, they did well. This approach presented a rationale for provision of rehabilitation services and a suggestion about which services were most needed for cancer patients. Additional studies supported the usefulness and appropriateness of inpatient rehabilitation (5–8). In fact, patients with brain tumors did as well functionally and had shorter length of hospital stay than those with stroke (9).

An important component of providing appropriate, quality care for cancer patients is good investigational work. Natural history studies, identifying the kinds of problems associated with cancer diagnoses, and clinical trials demonstrating which interventions are effective in reducing or preventing disability are critical resources for meeting the needs of these patients. Specifically, the work of Winningham and colleagues (10,11) demonstrated efficacy of aerobic training in reducing symptoms of cancer fatigue and improving functional outcomes. Dimeo demonstrated that in terms of symptoms, stamina and performance were better in bone marrow transplant recipients who received aerobic training than in those who did not (12). He further demonstrated that those who received a bicycle ergometer in the treatment room during their acute hospitalization for transplant, had improved levels of hemoglobin and white blood cell counts compared with those who did not receive in-room ergometry (13). This helped to establish the usefulness of an aerobic training program for cancer patients, and provided data to support the contention that exercise was safe during cancer treatment and had objective (eg, hematological) as well as subjective benefits.

This textbook reflects what has been learned from many of these studies. It includes results of studies of the natural history of cancer survivorship, from which we have identified problems that patients face and are of interest to them (eg, chemotherapy toxicities, impact of loss of limb, pain management, functional complications of bone marrow transplantation, etc.). It also includes important topics about rehabilitation interventions and effective treatments. For example, we have made great strides in understanding the value of exercise for cancer survivors, and, to some degree, how it works. This has enabled us to provide specific exercise prescriptions.

Cancer rehabilitation specialists have not agreed on standard core sets of evaluations or outcome measures for the cancer patient. Recent progress has been made in using new technologies to reduce the burden of data, such as item response theory, and in the quality of the psychometric properties of patient self-reports. The combination of standard objective measures of strength, range of motion, and other impairments; the use of more sensitive instruments for diagnosis and management (eg, infrared scanning for limb volume, EMG for diagnosis of neuropathy); and the widespread use of measures of symptoms, function, and quality of life, have helped define the necessary components for a comprehensive “metric” for the field. We now need to develop consensus and use these tools. These issues are discussed in this textbook, and several chapters make specific recommendations for the selection of appropriate and useful outcome measures.

Happily, cancer is no longer an acute, lethal illness. In my opinion, it is best thought of as a complex, chronic, and common disorder (14). Conceptually, the model of chronic illness best fits it. Cancers are likely to increase in prevalence as the population ages and the number of survivors increases. It will remain a challenge to treat. The biology of tumors varies considerably. Treatments for the tumor (radiation, surgery, chemotherapy, biologics) and the individual’s response to them vary among patients. The impact of cancer on an individual’s life is often dependent on phenomena not related to the tumor or its treatment, but rather to the individual’s life needs and values. These factors present the health care professional with opportunities for collaborations and continued challenges for which the oncological and rehabilitation communities must coordinate efforts.

These observations have been known to the rehabilitation oncology community and cancer survivors for decades; but only recently has rehabilitation been acknowledged as an important contributor to the health and well-being of cancer patients and survivors. Heretofore, we were called to treat problems that were often at very late stages, such as frozen shoulder or severe lymphedema; or a problem of mobility or transfer needing adaptive equipment. This was made clear to me by the omission of the need for integrating rehabilitation services into the first National Cancer Policy Board report, “Ensuring Quality Cancer Care” (15). Rehabilitation interventions were not part of its recommendations for quality, comprehensive cancer evaluation, and treatment. The board’s second report, “From Cancer Patient to Cancer Survivor: Lost in Transition,” does address these concerns (16). Including rehabilitation interventions in the second report acknowledges the increasingly important role that rehabilitation plays

in the lives of cancer survivors, and cites the evidence establishing efficacy of some rehabilitation treatment.

This textbook represents a milestone. It demonstrates the breadth of topics relevant to rehabilitation of the cancer patient. It also demonstrates that there is much that can be done for the cancer patient and survivor. The comprehensive nature of the content addresses the impairment, disability, and societal integration needs of this population of people. The publication of this text is likely to raise awareness of the advances in our field, the practical approach we offer for evaluating and solving problems of function, and the treatments we can offer our patients.

However, we have only just begun. Much work needs to be done to develop instruments to measure function and reconcile concerns about objective and self-reported measures. We still need to agree which are the best and most appropriate measures to use. Applying the rehabilitation model of impairment, disability, and handicap or the alternative International Classification of Disability, Functioning and Health will provide a consistent framework around which we can evaluate needs and response to treatment.

Efficacy of exercise in relieving some symptoms and improving function in the cancer survivor population has been demonstrated. Other rehabilitation interventions, such as bracing and manual therapy techniques, the use of modalities, complementary and alternative interventions have been used but would benefit from proper clinical trials.

We will need to devise interventions for all domains of the rehabilitation model. Models for delivery of care across the continuum of the phases of cancer and the life stages of survivors from infants to the very old should be evaluated for efficacy and efficiency. That is, we should evaluate the efficacy and accessibility of home health, outpatient, inpatient, and coordinated care services.

More clinical trials should be undertaken to further our goal of providing the best possible outcomes for cancer survivors. We believe the contributions of rehabilitation professionals can help improve and restore function, reduce the burden of disability, and help prevent functional decline; but more evidence is needed to demonstrate this. Achieving these outcomes will enable people who have survived cancer to attain their unique goals and enhance their quality of life. An important step in reaching these goals is to provide quality educational materials and improve access to the scope of rehabilitation practice in this population

of patients. This textbook provides a comprehensive approach to the practice and the knowledge base on which the practice has been constructed. It is our hope that readers will benefit from this and enhance the nature of their practice and, ultimately, improve the lives of cancer patients.

Lynn H. Gerber, MD Professor, Rehabilitation Science Director, Center for the Study of Chronic Illness and Disability College of Health and Human Services

George Mason University Fairfax, Virginia

RefeRenceS

1. Switzer ME. Clinical Conference on Cancer, In: Rehabilitation of the Cancer Patient. Clark RL, Moreton RD, Healey JC, et al., eds. Chicago: Year Book Medical Publishers, Inc.; 1972.

2. Clark RL. Introduction. In: Clark RL, Moreton RD, Healey JC, et al., eds. Rehabilitation of the Cancer Patient. Chicago: Year Book Medical Publishers, Inc.; 1972.

3. Deitz, JH, Jr. Rehabilitation Oncology. New York: Wiley & Sons; 1981.

4. Lehmann JF, DeLisa JA, Warren CG, et al. Cancer rehabilitation: assessment of need, development and evaluation of a model of care. Arch Phys Med Rehabil. 1978;59:410–419.

5. Marciniak CM, Sliwa JA, Spill G, et al. Functional outcome following rehabilitation of the cancer patient. Arch Phys Med Rehabil. 1996;77:54–57.

6. Huang ME, Wartella JE, Kreutzer JS. Functional outcomes and quality of life in patients with brain tumors: a preliminary report. Arch Phys Med Rehabil. 2001;82:1540–1546.

7. Cole RP, Scialla SJ, Bednarz L. Functional recovery in cancer rehabilitation. Arch Phys Med Rehabil. 2000; 81:623–627.

8. O’Dell MW, Barr K, Spanier D, et al. Functional outcomes of inpatient rehabilitation in persons with brain tumor. Arch Phys Med Rehabil. 1998;79:1530–1534.

9. Huang ME, Cifu DX, Keeper–Marcus L. Functional outcomes after brain tumor and acute stroke: a comparative analysis. Arch Phys Med Rehabil. 1998;79:1286–1290.

10. Winningham ML, Nail LM, Burke MD, et al. Fatigue and the cancer experience. Oncol Nurs Forum. 1994;21:23–36.

11. MacVicar MG, Winningham ML, Nickel JL. Effects of aerobic interval training of cancer patients’ functional capacity. Nursing Res. 1989;38:348–351.

12. Dimeo F, Rumberger BG, Keul J. Aerobic exercise training for cancer fatigue. Med Sci Sports Exer. 1998;4:475–478.

13. Dimeo FC, Tilmann MH, Bertz H, et al. Aerobic exercise in the rehabilitation of cancer patients after high dose chemotherapy and autologous peripheral stem cell transplant. Cancer 1997;79:1717–1722.

14. Gerber LH. Cancer rehabilitation into the future. Cancer 2001;92(4Suppl):975–979.

15. Hewitt, M, Simone,. Ensuring Quality Cancer Care. Washington DC: National Cancer Policy Board, 1999.

16. Hewitt, M. From Cancer Patient to Cancer Survivor: Lost in Transition. Washington DC: National Cancer Policy Board, 2005.

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Preface

As of June 2008, the Centers for Disease Control (CDC) estimated that there were approximately 11 million persons in the United States living with a previously diagnosed cancer (1). This compares with fewer than 300,000 survivors of spinal cord injury and represents a threefold increase from the estimated 3 million persons who were living with cancer in 1971 (2,3). Approximately 65% of persons diagnosed with cancer today can expect to live at least five years after diagnosis compared with only 35% in the 1950s (4). This increase in cancer survivorship, largely attributable to advances in early detection and treatment, has led to a paradigm shift in how the diagnosis of cancer is perceived. Patients are increasingly described as “cancer survivors” as opposed to “cancer victims” (2). The cost of cancer survivorship is high. Patients diagnosed with cancer may look forward to various combinations of disfiguring surgery, toxic chemotherapy, and the insidiously fibrotic effects of radiotherapy. All of these potentially life-saving or prolonging modalities can result in marked impairments in every aspect of their life and function.

This textbook is intended to provide a state-ofthe-art overview of the principles and practice of restoring function and quality of life to cancer survivors. The intended audience includes rehabilitation physicians, physical therapists, occupational therapists, nurses, oncologists, surgeons, and any other health care professionals with an interest in cancer rehabilitation. The

successful rehabilitation of cancer patients requires a working understanding of the various types of cancer and their treatments. To this end, the section on principles, authored by some of the world’s top cancer experts from wide-ranging disciplines including oncology, radiation oncology, neurosurgery, orthopedic surgery, and radiology, provides primer level overviews of the various cancer types, their evaluation, and treatment. The practice section of this text, authored by an even more diverse group of cancer rehabilitation and other specialists from a multitude of disciplines, details the identification, evaluation, and treatment of specific impairments and disabilities that result from cancer and the treatment of cancer.

The field of cancer rehabilitation has grown and changed dramatically since the pioneering work of Dietz more than a quarter century ago (5). Advances in our understanding of disease pathophysiology, improvements in imaging and electrodiagnostic testing, and enhanced treatment options including more effective medications and targeted procedures have uniquely positioned the physiatrist to benefit cancer survivors. At the Memorial Sloan-Kettering Cancer Center, the cancer rehabilitation specialist has moved into diagnostic and treatment planning roles. The rehabilitation team does not only evaluate and treat the neuromuscular and musculoskeletal pain and functional disorders associated with cancer and its treatment, but also works closely with the oncologist to determine the potential

morbidity and effectiveness of a given treatment. This partnership has evolved not only due to improved patient survival but as a result of a new emphasis on maintaining or improving the cancer patient’s function and quality of life. Many of the principles of cancer rehabilitation described in the text are borrowed from other rehabilitation specialties. For a variety of reasons, including to some degree fear and lack of knowledge about treating cancer patients, these principles have not been previously applied in the cancer setting. It is our intention that this work should be transformational for the discipline of cancer rehabilitation and lay the groundwork for this emerging specialty to take a leading role in cancer survivorship.

RefeRenceS

1. Centers for Disease Control (CDC). Notice to readers: cancer survivorship. June 2008. MMWR 2008;57:605–606.

2. CDC. Cancer survivorship: United States, 1971–2001. MMWR 2004;53:526–529.

3. The National SCI Statistical Center. Spinal Cord Injury Facts and Figures at a Glance 2008. Available at http://www.spinalcord.uab.edu/show .asp?durki=116979.

4. Ries LAG, Melbert D, Krapcho M, Stinchcomb DG, Howlader N, Horner MJ, et al. (eds). SEER Cancer Statistics Review, 1975–2005. National Cancer Institute. Bethesda, MD. Available at http://seer.cancer.gov/csr/1975_2005/, based on November 2007 SEER data submission, posted to the SEER web site, 2008.

5. Deitz, JH, Jr. Rehabilitation Oncology . New York: Wiley & Sons; 1981.

Acknowledgments

Our gratitude to Theresa W. Fitzpatrick, PT, MBA and Christian M. Custodio, MD for their invaluable assistance in formulating the scope and content of this textbook.

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Contributors

Laura Andima, MD

Staff Anesthesiologist

VA Boston Healthcare System

Instructor Anesthesiology

Harvard Medical School

Cambridge, Massachusetts

Edward K. Avila, DO

Assistant Attending Neurologist Department of Neurology

Memorial Sloan-Kettering Cancer Center

New York, New York

Matthew N. Bartels, MD, MPH

John E. Dewey Associate Professor of Clinical Rehabilitation Medicine

Department of Rehabilitation Medicine

Columbia College of Physicians and Surgeons

Columbia University

New York, New York

Mark H. Bilsky, MD

Associate Attending Surgeon Department of Neurosurgery

Memorial Sloan-Kettering Cancer Center

Associate Professor Department of Neurological Surgery

Weill Cornell Medical College

New York, New York

Victoria Blinder, MD, MSc Department of Epidemiology and Biostatistics Health Outcomes Research Group Department of Medicine Breast Cancer Medicine Service Memorial Sloan-Kettering Cancer Center New York, New York

Patrick J. Boland, MD Attending Orthopaedic Surgeon Orthopaedic Service Department of Surgery Memorial Sloan-Kettering Medical Center New York, New York

Julia F. Boysen, PT Assistant Supervisor PM&R Rochester Methodist Hospital Rochester, Minnesota

Thomas H. Brannagan, III, MD

Associate Professor of Clinical Neurology Director, Peripheral Neuropathy Center Columbia University College of Physicians and Surgeons Co-director, EMG Laboratory

New York-Presbyterian Hospital New York, New York

Claudine Levy Campbell, OTR/L

Chief of Occupational Therapy

Rehabilitation Medicine Service

Department of Neurology

Memorial Sloan-Kettering Medical Center

New York, New York

Kristen E. Cardamone, DO

Fellow, Orthopedic Sports and Spine Rehabilitation

Beth Israel Medical Center

Continuum Center for Health and Healing/Spine Institute of New York

New York, New York

Barrie R. Cassileth, MS, PhD

Chief, Integrative Medicine Service

Department of Medicine

Memorial Sloan-Kettering Cancer Center New York, New York

Melissa M. Center, MPH

Epidemiologist

Surveillance and Health Policy Research

American Cancer Society Atlanta, Georgia

Leighton Chan, MD, PhD

Chief, Rehabilitation Medicine Department

National Institutes of Health Bethesda, Maryland

Andrea L. Cheville, MD, MSCE

Associate Professor of Physical Medicine and Rehabilitation

Mayo Clinic

Rochester, Minnesota

Dennis S. Chi, MD

Gynecology Service

Department of Surgery

Memorial Sloan-Kettering Cancer Center

New York, New York

Kenneth Cubert, MD

Associate Attending Anesthesiologist Pain Service

Department of Anesthesiology and Critical Care Medicine

Memorial Sloan-Kettering Cancer Center

New York, New York

Edward J. Cupler, MD

Associate Professor

Department of Neurology Director, Neuromuscular Disease Center

Oregon Health and Science University

Portland, Oregon

Christian M. Custodio, MD

Assistant Attending Physiatrist

Rehabilitation Medicine Service Department of Neurology

Memorial Sloan-Kettering Cancer Center New York, New York

Lisa M. DeAngelis, MD Chair Department of Neurology

Memorial Sloan-Kettering Cancer Center New York, New York

Robert W. DePompolo, MD Director

Cancer Rehabilitation Program Mayo Clinic Rochester, Minnesota

Tim Dillingham, MD Professor and Chairman Physical Medicine and Rehabilitation Medical College of Wisconsin Milwaukee, Wisconsin

Joseph J. Disa, MD

Associate Attending Surgeon Plastic and Reconstructive Surgery Service Memorial Sloan-Kettering Cancer Center New York, New York

Don S. Dizon, MD, FACP Assistant Professor Department of Obstetrics/Gynecology and Medicine

Warren Alpert Medical School Brown University Director, Medical Oncology and Integrative Care Co-Director, Center for Sexuality, Intimacy and Fertility Program in Women’s Oncology Women and Infants Hospital Providence, Rhode Island

Edward J. Dropcho, MD Professor, Department of Neurology Director, Neuro-Oncology Program Indiana University Medical Center Indianapolis, Indiana

Austin Duffy, MD Clinical Fellow

Medical Oncology Branch

National Cancer Institute Bethesda, Maryland

Erin Embry, MS CCC-SLP

Instructor, Clinical Supervisor, Graduate Advisor Department of Speech-Language Pathology and Audiology

New York University

New York, New York

Noel G. Espiritu, DPT

Chief Physical Therapist Rehabilitation Medicine Service Department of Neurology

Memorial Sloan-Kettering Cancer Center New York, New York

Mill Etienne, MD Fellow, Division of Epileptology Department of Neurology Columbia University New York, New York

Azeez Farooki, MD

Assistant Attending Physician Endocrinology Service Department of Medicine Memorial Sloan-Kettering Cancer Center

New York, New York

Mark A. Ferrante MD Associate Professor Co-Director, Neuromuscular Division Director, EMG Laboratory Department of Neurology University of Texas Health Science Center San Antonio, Texas

Teresa W. Fitzpatrick, PT, MBA Rehabilitation Manager Rehabilitation Medicine Service Department of Neurology

Memorial Sloan-Kettering Cancer Center New York, New York

Kevin Fox, MD

Marianne T. and Robert J. MacDonald Professor in Breast Cancer Care Excellence Department of Medicine

Hospital of the University of Pennsylvania Philadelphia, Pennsylvania

Debora Julie Franklin, PhD, MD

Director Cancer Rehabilitation

Assistant Professor Department of Rehabilitation Medicine

Thomas Jefferson University Philadelphia, Pennsylvania

Stacey Franz, DO, MSPT Fellow, Musculoskeletal Medicine, Interventional Spine Care, Sports Medicine & Pain Management Kessler Institute for Rehabilitation University of Medicine and Dentistry of New Jersey Newark, New Jersey

Mark A. Frattini, Md, PhD Assistant Member Department of Medicine Memorial Sloan-Kettering Medical Center New York, New York

Megan L. Freeland, PT, DPT Physical Therapist Rehabilitation Medicine Service Department of Neurology Memorial Sloan-Kettering Cancer Center New York, New York

Gail Louise Gamble, MD Medical Director Cancer Rehabilitation Rehabilitation Institute of Chicago Chicago, Illinois

Sandy B. Ganz, PT, DSc, GCS Director of Rehabiliation Amsterdam Nursing Home New York, New York

Susan V. Garstang, MD Assistant Professor Department of Physical Medicine and Rehabilitation University of Medicine and Dentistry of New Jersey Newark, New Jersey

Lynn H. Gerber, MD Director, Center for Chronic Illness and Disability Department of Global and Community Health College of Health and Human Services George Mason University Fairfax, Virginia

Jorge E. Gomez, MD Assistant Professor of Medicine

UM Sylvester Comprehensive Cancer Center Miller School of Medicine University of Miami Miami, Florida

Clifton L. Gooch, MD

Professor and Chairman Department of Neurology

University of South Florida College of Medicine Tampa, Florida

Eric Graf

Senior Research Assistant Neuromuscular Disease Center

Oregon Health and Sciences University Portland, Oregon

Sean A. Grimm, MD

Assistant Professor of Neurology Feinberg School of Medicine Northwestern University Chicago, Illinois

Jyothirmai Gubili, MS

Assistant Editor

Integrative Medicine Service

Memorial Sloan-Kettering Cancer Center New York, New York

Amitabh Gulati, MD

Assistant Attending Anesthesiologist

Pain Service

Department of Anesthesiology and Critical Care Medicine

Memorial Sloan-Kettering Cancer Center

New York, New York

Sakir Humayun Gultekin

Assistant Professor Department of Pathology

Director, Neuromuscular Pathology Laboratory

Oregon Health and Science University Portland, Oregon

Georgi Guruli, MD, PhD

Associate Professor

Director of Urologic Oncology Department of Surgery

Virginia Commonwealth University School of Medicine

Richmond, Virginia

James Han, MD

Resident Physician

Department of Physical Medicine and Rehabilitation

Hospital of the University of Pennsylvania Philadelphia, Pennsylvania

Maryann Herklotz, PT Assistant Chief Physical Therapist Rehabilitation Medicine Service Department of Neurology

Memorial Sloan-Kettering Cancer Center New York, New York

Robin C. Hindery, MS Medical Writer Integrative Medicine Service Department of Medicine

Memorial Sloan-Kettering Cancer Center New York, New York

Margaret L. Ho, MA, CCC-SLP Supervisor, Speech and Swallowing Services Head and Neck Service Department of Surgery

Memorial Sloan-Kettering Cancer Center New York, New York

Jimmie C. Holland, MD

Wayne E. Chapman Chair in Psychiatric Oncology Attending Psychiatrist Department of Psychiatry and Behavioral Sciences

Memorial Sloan-Kettering Cancer Center New York, New York

Dory Hottensen, LCSW Senior Social Worker, Palliative Care Department of Social Work New York-Presbyterian Hospital Weill Cornell Medical Center New York, New York

Clifford A. Hudis, MD Chief, Breast Cancer Medicine Service Department of Medicine

Memorial Sloan-Kettering Cancer Center New York, New York

Ahmedin Jemal, DVM, PhD Department of Epidemiology and Surveillance Research

American Cancer Society Atlanta, Georgia

Juan Miguel Jimenez-Andrade, PhD Research Assistant Professor Department of Pharmacology University of Arizona Tucson, Arizona

C. George Kevorkian, MD

Associate Professor and Vice Chair

Department of Physical Medicine and Rehabilitation

Baylor College of Medicine

Chief of Service

Department of Physical Medicine and Rehabilitation

St. Luke’s Episcopal Hospital

Houston, Texas

Juliana Khowong, MD

Clinical Instructor

Department of Rehabilitation Medicine

Columbia University College of Physicians and Surgeons

New York, New York

Elizabeth M. Kilgore, MD, MS, FAAPM&R

Assistant Professor of Clinical Rehabilitation Medicine

Georgetown University Medical Center Director, Cancer Rehabilitation Program

National Rehabilitation Hospital

Washington, DC

Tari A. King, MD

Assistant Attending Surgeon Breast Service

Department of Surgery

Jeanne A. Petnek Junior Faculty Chair

Memorial Sloan-Kettering Cancer Center

New York, New York

Guenther Koehne, MD, PhD

Attending Physician

Allogeneic Bone Marrow Transplantation Service

Department of Medicine

Memorial Sloan-Kettering Cancer Center

Assistant Professor

Weill Cornell Medical College of Cornell University

New York, New York

George Krol, MD

Attending Neuroradiologist

Department of Radiology

Neuroradiology Service

Memorial Sloan-Kettering Cancer Center

Professor of Clinical Radiology

Weill Cornell Medical College of Cornell University

New York, New York

Michael Krychman, MD, FACOG

Medical Director

The Sexual Medicine Center at Hoag

Executive Director

The Southern California Center for Sexual Health and Survivorship Medicine

Newport Beach, California

Associate Clinical Professor

University of Southern California Los Angeles, California

Heather J. Landau, MD

Assistant Attending Hematology Service Department of Medicine

Memorial Sloan-Kettering Cancer Center New York, New York

Christine Laviano, OTR/L

Head Occupational Therapist Acute Care

Rehabilitation Medicine Service Department of Neurology NewYork-Presbyterian Hospital Columbia University Medical Center New York, New York

Rebecca Leboeuf, MD

Assistant Professor of Medicine

Assistant Attending Physician Endocrinology Service Department of Medicine

Memorial Sloan-Kettering Cancer Center New York, New York

Taryn Y. Lee, MD

Assistant Professor of Medicine Division of Geriatrics and Gerontology

Weill Cornell Medical College of Cornell University

Assistant Attending Physician

New York-Presbyterian Hospital New York, New York

Marsha Leight, PT

Senior Physical Therapist

Rehabilitation Medicine Service Department of Neurology

Memorial Sloan-Kettering Cancer Center New York, New York

Jon Lewis, MD

Neuroradiology Fellow

Department of Radiology

Neuroradiology Service

New York-Presbyterian Medical Center

Memorial Sloan-Kettering Cancer Center

New York, New York

Su Hsien Lim, MD

Medical Oncology and Hematology, PC

Yale-New Haven Shoreline Medical Center

Guilford, Connecticut

C. David Lin, MD

Ida and Theo Rossi Di Montelera Assistant Professor of Rehabilitation Medicine Department of Rehabilitation

Weill Cornell Medical College of Cornell University Assistant Attending

New York-Presbyterian Hospital

Weill Cornell Medical Center

New York, New York

Julie Lin, MD

Assistant Attending Physiatrist Physiatry Department

Hospital for Special Surgery Assistant Professor Department of Rehabilitation Medicine

New York-Presbyterian Hospital

New York, New York

Todd A. Linsenmeyer, MD

Director of Urology

Kessler Institute for Rehabilitation

West Orange, New Jersey

Professor Department of Surgery

Professor

Department of Physical Medicine and Rehabilitation University of Medicine and Dentistry of New Jersey

Newark, New Jersey

Eric Lis, MD

Associate Attending Neuroradiologist

Director of Neurointerventional Radiology Department of Radiology

Neuroradiology Service

Memorial Sloan-Kettering Cancer Center New York, New York

Laura Locati, MD Instituto Nazionale Tumori Department of Medical Oncology Milan, Italy

Paul Magda, DO Clinical Assistant Professor of Neurology Department of Neurology St. Vincent’s Catholic Medical Center-Manhattan New York, New York

Robert G. Maki, MD, PhD Associate Member and Co-Director Adult Sarcoma Program Department of Medicine

Memorial Sloan-Kettering Cancer Center New York, New York

Vicky Makker Assistant Member Gynecologic Medical Oncology Service Department of Medicine

Memorial Sloan-Kettering Cancer Center New York, New York

Patrick W. Mantyh, PhD Professor Department of Pharmacology University of Arizona Tucson, Arizona

Enrica Marchi, MD Herbert Irving Comprehensive Cancer Center New York, New York

Madhu Mazumdar, PhD, MA, MS Professor of Biostatistics in Public Health Chief, Division of Biostatistics and Epidemiology Department of Public Health

Weill Cornell Medical College of Cornell University New York, New York

Christopher Mazzone Neuroradiology Research Assistant Department of Radiology

Neuroradiology Service

Memorial Sloan-Kettering Cancer Center New York, New York

Heather L. McArthur, MD, MPH Clinical Research Fellow Breast Cancer Medicine Service Department of Medicine

Memorial Sloan-Kettering Cancer Center New York, New York

Colleen M. McCarthy, MD, MS

Assistant Attending Surgeon Plastic and Reconstructive Service Department of Surgery

Memorial Sloan-Kettering Cancer Center New York, New York

William McKinley, MD

Director, Spinal Cord Injury Medicine Professor of Physical Medicine and Rehabilitation

Virginia Commonwealth University Medical Center Richmond, Virginia

Sarah A. McLaughlin, MD

Assistant Professor of Surgery Department of Surgery Mayo Clinic Jacksonville, Florida

Veronica McLymont, MD, RD, CDN

Director Food and Nutrition Services

Memorial Sloan-Kettering Cancer Center New York, New York

Amit B. Mehta, MD

Anesthesiologist and Interventional Pain Physician

Premier Pain Specialists Co-founder Co-director of the Division of Pain Management at MacNeal Hospital Chicago, Berwyn, and Schaumburg, Illinois

Neel Mehta, MD

Resident Department of Anesthesiology Weill Cornell Medical College of Cornell University New York, New York

Christina A. Meyers, PhD, ABPP Professor and Chief

Section of Neurophysiology

M.D. Anderson Cancer Center Houston, Texas

Amanda Molnar, MSPT

Senior Physical Therapist

Rehabilitation Medicine Service Department of Neurology

Memorial Sloan-Kettering Cancer Center

New York, New York

Alexei Morozov, MD, PhD Fellow, Hermatology-Oncology Department of Medicine

Memorial Sloan-Kettering Cancer Center New York, New York

Carol D. Morris, MD, MS Associate Attending Surgeon Orthopedic Surgery Service Department of Surgery

Memorial Sloan-Kettering Cancer Center New York, New York

Natalie Moryl, MD Assistant Attending Pain and Palliative Care Service Department of Medicine

Memorial Sloan-Kettering Cancer Center New York, New York

Rajaram Nagarajan, MD, MS Assistant Professor of Pediatrics Department of Pediatrics Cincinnati Children’s Hospital Medical Center University of Cincinnati College of Medicine Cincinnati, Ohio

Stephen D. Nimer, MD Chief, Hematology Service Vice Chair, Faculty Development Department of Medicine

Alfred Sloan Chair

Memorial Sloan-Kettering Cancer Center New York, New York

Owen A. O’Connor, MD, PhD Director Lymphoid Development and Malignancy Program Herbert Irving Comprehensive Cancer Center Chief, Lymphoma Service College of Physicians and Surgeons

New York-Presbyterian Hospital Columbia University New York, New York

Michael W. O’Dell, MD Chief of Clinical Services Department of Rehabilitation Medicine

New York-Presbyterian Hospital

Weill Cornell Medical Center Professor of Clinical Rehabilitation Medicine

Weill Cornell Medical College of Cornell University New York, New York

Kristen M. O’Dwyer, MD

Leukemia Service

Department of Medicine

Memorial Sloan-Kettering Cancer Center

New York, New York

Kevin C. Oeffinger, MD

Attending and Member

Director

Adult Long Term Follow Up Program Departments of Pediatrics and Medicine

Memorial Sloan-Kettering Cancer Center

New York, New York

Gary C. O’Toole, BSc, MCh, FRCS

Consultant, Orthopaedic Surgeon

St. Vincent’s University Hospital

Cappagh National Orthopaedic Hospital Dublin, Ireland

Lora Packel, MS, PT, CCS

Assistant Professor Department of Physical Therapy University of the Sciences Philadelphia, Pennsylvania

Meena J. Palayekar, MD

Department of Obstetrics and Gynecology

Saint Peter’s University Hospital

New Brunswick, New Jersey

Desiree A. Pardi, MD, PhD

Assistant Professor of Medicine

Division of Geriatrics and Gerontology

Weill Cornell Medical College of Cornell University Director, Palliative Care Service

New York-Presbyterian Hospital New York, New York

Rebecca A. Parks, MS, OTR/L, BCP, FAOTA

U.S. Public Health Service

National Institutes of Health Bethesda, Maryland

Snehal Patel, MD

Attending Surgeon Head and Neck Service Department of Surgery

Memorial Sloan-Kettering Cancer Center

New York, New York

Mackenzi Pergolotti, MS, OTR/L Assistant Chief of Occupational Therapy Rehabilitation Medicine Service Department of Neurology Memorial Sloan-Kettering Cancer Center New York, New York

Lucinda Pfalzer, PhD, PT, FACSM Department of Physical Therapy University of Michigan-Flint Flint, Michigan

David G. Pfister, MD Member and Attending Physician Chief, Head and Neck Medical Oncology Co-leader, Head and Neck Cancer Disease Management Team

Memorial Sloan-Kettering Cancer Center New York, New York

Cynthia G. Pineda, MD, FAAPM&R Assistant Profesor of Clinical Rehabilitation Medicine

Georgetown University Medical Center Staff Physiatrist National Rehabilitation Hospital Washington, DC

Tara Post, OTR/L, ATP Supervisor, Occupational Therapy Department of Rehabilitation Medicine New York-Presbyterian Hospital Weill Cornell Medical Center New York, New York

David William Pruitt, MD Assistant Professor, Clinical Pediatrics and Clinical PMSR Department of Pediatrics Cincinnati Children’s Hospital Medical Center University of Cincinnati College of Medicine Cincinnati, Ohio

Hanna Chua Rimner, BScPT Senior Physical Therapist Rehabilitation Medicine Service Department of Neurology

Memorial Sloan-Kettering Cancer Center New York, New York

Justin C. Riutta, MD, FAAPMR Director of Lymphedema and Breast Cancer Rehabilitation

William Beaumont Hospital

Royal Oak, Michigan

Corey Rothrock, MD

Clinical Instructor, Orthopedic Surgery

Musculoskeletal Oncology

Norton Cancer Institute

University of Louisville

Louisville, Kentucky

Yvonne Saenger, MD

Assistant Professor

Department of Medicine, Hematology and Medical Oncology

Mount Sinai School of Medicine

New York, New York

Leonard B. Saltz, MD

Attending Oncologist

Gastrointestinal Oncology Service

Department of Medicine

Memorial Sloan-Kettering Cancer Center

Professor of Medicine

Weill Cornell Medical College of Cornell University

New York, New York

Sonia K. Sandhu, DO

Assistant Professor

Co-Director, Intraoperative Neurophysiologic Monitoring

Department of Neurology and Neuroscience

Weill Cornell Medical College of Cornell University

New York-Presbyterian Hospital

New York, New York

Annelise Savodnik, PT, MPT, CLT

Senior Physical Therapist

Rehabilitation Medicine Service

Department of Neurology

Memorial Sloan-Kettering Cancer Center

New York, New York

Oksana Sayko, MD

Assistant Professor

Department of Physical Medicine and Rehabilitation

Medical College of Wisconsin

Milwaukee, Wisconsin

Elizabeth Schack, RN, GNP, CNS

Nurse Practitioner

Palliative Care Service

New York-Presbyterian Hospital

Weill Cornell Medical Center

New York, New York

Mary J. Scherbring, CNS, RN

Prior Clinical Nurse Specialist on Cancer and Adaptation Team

Mayo Clinic

Rochester, Minnesota

Eric Schwabe, PT, MS

Supervisor, Physical Therapy

The Sue and John L. Weinberg Inpatient Rehabilitation Center

Department of Rehabilitation

New York-Presbyterian Hospital

Weill Cornell Medical Center

New York, New York

Julie K. Silver, MD

Assistant Professor

Harvard Medical School Chief Editor of Books

Harvard Health Publications Countway Library Boston, Massachusetts

Susan F. Slovin, MD, PhD

Associate Attending Oncologist Genitourinary Oncology Service Department of Medicine

Memorial Sloan-Kettering Cancer Center New York, New York

Rebecca G. Smith, MD, MS

Assistant Professor and Chief, Division of Cancer Rehabilitation

Department of Physical Medicine and Rehabilitation Hospital of the University of Pennsylvania Philadelphia, Pennsylvania

Beth Solomon, MS, CCC-SLP

Chief, Speech Language Pathology Section Rehabilitation Medicine Department National Institutes of Health Bethesda, Maryland

David Spriggs, MD Head, Division of Solid Tumor Oncology

Winthrop Rockefeller Chair in Medical Oncology

Memorial Sloan-Kettering Cancer Center

New York, New York

Argyrios Stampas, MD

Resident Physician

Department of Physical Medicine and Rehabilitation Hospital of the University of Pennsylvania Philadelphia, Pennsylvania

Michelle Stern, MD

Assistant Clinical Professor

Columbia University College of Physicians and Surgeons

New York-Presbyterian Hospital

New York, New York

Jessica Stiles, MD

Department of Psychiatry and Behavioral Sciences

Memorial Sloan Kettering Cancer Center

New York, New York

David Martin Strick, PhD, PT

Senior Lymphedema Therapist

Mayo Clinic

Rochester, Minnesota

Michael D. Stubblefield, MD

Assistant Attending Physiatrist

Rehabilitation Medicine Service

Department of Neurology

Memorial Sloan-Kettering Cancer Center

Assistant Professor of Rehabilitation Medicine

Weill Cornell Medical College of Cornell University

New York, New York

Ping Sun, DPT

Senior Physical Therapist

Rehabilitation Medicine Service

Department of Neurology

Memorial Sloan-Kettering Cancer Center

New York, New York

Sharlynn M. Tuohy, PT, MBA

Assistant Chief Physical Therapist

Rehabilitation Medicine Service

Department of Neurology

Memorial Sloan-Kettering Cancer Center

New York, New York

Robert Michael Tuttle, MD

Professor of Medicine

Attending Physician

Endocrinology Service

Department of Medicine

Memorial Sloan-Kettering Cancer Center

New York, New York

Tracy L. Veramonti, PhD

Neuropsychologist

The Institute for Rehabilitation and Research

Memorial Hermann Hospital

Clinical Assistant Professor

Department of Physical Medicine and Rehabilitation

Baylor College of Medicine

Houston, Texas

Louis H. Weimer, MD

Associate Clinical Professor of Neurology Director, EMG laboratory

Co-director, Columbia Neuropathy Research Center

Columbia University College of Physicians and Surgeons

New York, New York

Talia R. Weiss, MD

Department of Psychiatry and Behavioral Sciences

Memorial Sloan-Kettering Cancer Center

New York, New York

Golda B. Widawski, PT, MPT

Senior Physical Therapist Department of Rehabilitation Medicine

New York-Presbyterian Hospital

Weill Cornell Medical Center

New York, New York

Jill R. Wing, PT, DPT

Assistant Chief Physical Therapist

Rehabilitation Medicine Service Department of Neurology

Memorial Sloan-Kettering Cancer Center

New York, New York

Jedd D. Wolchok, MD, PhD

Associate Attending Melanoma and Sarcoma Service Department of Medicine

Memorial Sloan-Kettering Cancer Center

New York, New York

Yoshiya Yamada, MD, FRCPC

Assistant Attending Radiation Oncologist Department of Radiation Oncology

Memorial Sloan-Kettering Cancer Center

New York, New York

David S. Younger, MD

Chief of Neuromuscular Diseases

Associate Clinical Professor Department of Neurology

New York University School of Medicine

New York, New York

Jasmine Zain, MD

Assistant Clinical Professor

Columbia University Medical Center

New York, New York

Cancer Rehabilitation

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PRINCIPLES OF CANCER AND CANCER TREATMENT

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