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ChapterInReview

Chapter4:TheActualECG:PaperandInk

BoxesandSizes

Calibration

WhereIsEachLeadRepresented?

TemporalRelationshipoftheECG

WhyIsTemporalSpacingImportant?

ChapterInReview

Chapter5:ECGTools

Calipers:TheECGInterpreter’sBestFriend

HowtoUseYourCalipers

ComparingWaveHeights

AddingWaveHeights

ComparingWidths

Axis-WheelRuler

ECGRulers

StraightEdge

Chapter6:TheBasicBeat

IntroductiontoBasicComponents

WaveNomenclature

IndividualComponentsoftheECGComplex

ThePWave

TheTpWave

ThePRSegment

ThePRInterval

TheQRSComplex

TheSTSegment

TheTWave

TheQTInterval

TheUWave

AdditionalIntervals

TheCardiacCycleandComplexFormation

ChapterInReview

Chapter7:TheRate

EstablishingtheRate

NormalandFastRates

BradycardicRates

Let’spracticecalculatingsomerates

Calculatetherates

ChapterInReview

Chapter8:Rhythms

MajorConcepts

General

PWaves

QRSComplexes

IndividualRhythms

SupraventricularRhythms

VentricularRhythms

HeartBlocks

ChapterInReview

PART2:ECGINTERPRETATION

Chapter9:ThePWave

Overview

ECGCaseStudy:PWaveBasics

PWaveMorphology

ECGCaseStudies:PWaveMorphology

AbnormalPWaves

P-mitrale

ECGCaseStudies:P-mitrale

P-pulmonale

ECGCaseStudies:P-pulmonale

IntraatrialConductionDelay(IACD)

ECGCaseStudies:BiphasicPWaves

BiatrialEnlargement

ECGCaseStudies:BiatrialEnlargement

ChapterInReview

Chapter10:ThePRInterval

ConductionOverview

PRDepression

ECGCaseStudy:PRIntervalDepression

MeasuringtheInterval

ShortPRInterval

ECGCaseStudy:ShortPRInterval

Wolff-Parkinson-WhiteSyndrome(WPW)

ECGCaseStudies:WPW

WPWSyndrome AdvancedInformation

ProlongedPRInterval

ECGCaseStudy:ProlongedPRInterval

ChapterInReview

Chapter11:TheQRSComplex

WhattoLookforintheQRSComplex

QRSHeight(Amplitude)

AbnormalAmplitude

ECGCaseStudies:PericardialEffusion

ECGCaseStudy:LargeQRSComplexes

LeftVentricularHypertrophy(LVH)

ElectrocardiogramCriteriaforLeftVentricularHypertrophy

IdentifyingLeftVentricularHypertrophy,StepbyStep

ECGCaseStudies:LeftVentricularHypertrophy

RightVentricularHypertrophy(RVH)

RVHandtheECG

ECGCaseStudies:RightVentricularHypertrophy

QRSDuration

ECGCaseStudies:QRSDuration

TheWide-QRSDifferential,Simplified QRSMorphology

ECGCaseStudies:QRSMorphology

QWaveSignificance

BenignQWaves

RespiratoryVariationofQWaves207

ECGCaseStudies:QWaveSignificance

Significant(Pathological)QWaves

TransitionZone

ECGCaseStudies:TransitionZone

QRSNotching

Osborn(J)Waves

ECGCaseStudies:QRSNotchingandOsbornWaves

ChapterInReview

Chapter12:TheElectricalAxis

HowtoCalculatetheElectricalAxis

IsolatingtheAxis

1

4

5

CausesofAxisDeviation

RightAxisDeviation LeftAxisDeviation

TheZAxis

TheZAxisPrecordialLeadSystem

MoreExamples:AddingtheZAxis

ZAxis:OtherApproaches

ChapterInReview

Chapter13:BundleBranchBlocksandHemiblocks

RightBundleBranchBlock

ECGFindingsinRightBundleBranchBlocks

TheQR′Wave

ECGCaseStudies:RightBundleBranchBlock

LeftBundleBranchBlock

CriteriaforDiagnosingLBBB

ECGCaseStudies:LeftBundleBranchBlock

IntraventricularConductionDelay(IVCD)

SummaryCommentsonBundleBranchBlocks

ECGCaseStudies:IntraventricularConductionDelay Hemiblocks

LeftAnteriorHemiblock

ECGCaseStudies:LeftAnteriorHemiblock

LeftPosteriorHemiblock

ECGCaseStudies:LeftPosteriorHemiblock

BifascicularBlocks

ECGCaseStudies:BifascicularBlock

ChapterInReview

Chapter14:STSegmentandTWaves

Basics

WhereIstheJPoint?

STElevationorDepression

STSegmentShapes

TheTWave

ECGCaseStudies:STSegmentsandTWaves

IschemiaandInjury

ECGCaseStudies:IschemiaandInjury

StrainPattern

RightVentricularStrainPattern

ECGCaseStudies:RightVentricularStrainPattern

LeftVentricularStrainPattern

ECGCaseStudies:LeftVentricularStrainPattern

ECGComparisons:BenignChangesVersusInfarct

PericarditisRevisited

ECGCaseStudies:Pericarditis

STsandTWavesinBlocks

ECGCaseStudies:STsandTsinBlocks

ChapterInReview

Chapter15:AcuteMyocardialInfarction(AMI)

Introduction

ZonesofIschemia,Injury,andInfarction

AcuteCoronarySyndromes

InfarctandQWaves

QWaveInfarct

Non–QWaveInfarct

ECGProgressioninInfarct

ReciprocalChanges

InfarctRegionsontheECG

InfarctRegionsinCombination

AnteriorWallAMI

AnteroseptalMI

ECGCaseStudies:AnteroseptalAMI

AnteroseptalAMIwithLateralExtension

ECGCaseStudies:AnteroseptalAMIwithLateralExtension

LateralWallAMI

ECGCaseStudy:LateralWallAMI

InferiorWallAMI

ECGCaseStudies:InferiorWallAMI

InferolateralAMI

ECGCaseStudies:InferolateralAMI

ApicalAMI

ECGCaseStudies:ApicalAMI

AdditionalECGLeads

PlacingAdditionalRight-SidedLeads

PlacingAdditionalPosteriorLeads

RightVentricularAMI

CriteriaforRightVentricularInfarction

RightVentricularAMI:Summary

ECGCaseStudies:RightVentricularInfarction

PosteriorWallAMI

CarouselPoniesAreBadontheECG

PosteriorWallMI:Summary

ECGCaseStudies:PosteriorWallAMI

ECGCaseStudies:InferoposteriorAMI

ECGCaseStudies:Inferior-RV-PosteriorAMI

Conclusion

ChapterInReview

Chapter16:ElectrolyteandDrugEffects

HyperkalemiaandItsEffects

TheSpectrumofHyperkalemia

TWaveAbnormalitiesinHyperkalemia

ECGCaseStudies:TWaveChangesinHyperkalemia

IVCDandHyperkalemia

PWavesandHyperkalemia

ECGCaseStudies:IVCDandPWavesinHyperkalemia

OtherElectrolyteAbnormalities

Hypokalemia

Hypercalcemia

Hypocalcemia

ECGCaseStudies:OtherElectrolyteAbnormalities

DrugEffects

Digoxin

ECGCaseStudies:DrugEffects

ChapterInReview

Chapter17:PuttingItAllTogether

NewGround

TheQuestionsoftheGram

1.WhatIsMyGeneralImpression?

2 IsThereAnythingThatSticksOut?

3 WhatIstheRate?

4 WhatAretheIntervals?

5 WhatIstheRhythm?

6.WhatIstheAxis?

7 IsThereAnyHypertrophy?

8 IsThereAnyIschemiaorInfarction?

9 WhatIstheDifferentialDiagnosisoftheAbnormality?

10 HowCanIPutItAllTogetherwiththePatient?

TheBigPicture

PART3:TESTECGS

TestECGs

TestECGAnswers

Acronyms

AdditionalReadings Glossary

AuthorAcknowledgments

IwouldliketobeginbythankingallofthoseeducatorsandclinicianswhospentcountlesshoursteachingthespecificsofmedicineItwasthrough yourhardworkandperseverancethatwelearnhowtotreatpatientsYouallowustheprivilegeofbecominghealersBesecureintheknowledge that,justasripplesflowacrossapond,sotheripplesofknowledgethatyouhaveimpartedtousshallcontinueontheirjourneytolightthewayfor futurecliniciansWehopethatwehaveliveduptoyourexpectationsandhavenotletyoudown

Iwouldalsoliketothankallofthecountlessstudents,residents,paramedics,nurses,EMTs,physicianassistants,andtechniciansthathave askeduscountlessquestionsandcontinuallyquestionedourauthorityItisbyansweringyourquestionsthatwehoneourknowledgeandexpand ourabilitiestoteachYouallowustopassontheknowledgethatwehavelearnedandthisis,inouropinion,ourgreatesthonorAlwayscontinue toquestioneveryoneandchallengethe“standard”thinkingofthetime,becausestagnationistheworstthingthatcouldhappentomedicine

IwouldliketothankJones&BartlettLearningforhavingtheforesighttopublishabookthatdoesnotconformtothe“norm”Iwouldespeciallylike toexpressappreciationandheartfeltgratitudetotheeditorsofthefirstedition:TracyFoss,LorenMarshall,andCynthiaMacielKnowles,andthe editorsofthesecondedition:ChristineEmertonandCarolGuerreroTracy,thanksforbelievinginourproposalandforyoursupportthroughout thefirsteditionCarol,thanksforputtingupwiththedailyphonecallsandtheoccasionaltantrumYourinput,daybyday,moldedthisbookintoa realityLoren,yourinsightsandsuggestionswereappreciatedandinvaluableCynthia,yourhardworkandguidancetransformedthemanuscript intoabook.WethankallofJones&BartlettLearningforyourhardworkandfortheblood,sweat,andtearsthatyouhavepouredintoboth editions.

Finally,IwouldliketothankmyfamilyandfriendswhohavesacrificedtimeawaysothatIcouldaccomplishthisachievement.Iknowthatitistime thatwillneverbereplaced.Someofthepricespaidhavebeenhigh.Hopefully,thelivessavedbecauseoftheinformationpassedonwillbesome consolation.Ithankyou,loveyou,andwillbeforeverinyourdebt.

TomasBGarcia,MD

PublisherAcknowledgments

Jones&BartlettLearningandtheauthorwouldliketothankthefollowingpeopleforreviewingthistext

JohnAmtmann,EdD

Professor AppliedHealthScience MontanaTech

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Director,DoctorofNursingPracticeProgram

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DirectorofHealthandPublicSafety DavidsonCountyCommunityCollege

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DedicationandBiography

IdedicatethisbooktothetwomostwonderfulandamazingpeopleIknow,myMomandDadThankyouforthelove,understanding,support,and toleranceyouhavegivenmethroughouttheyearsYouhavebeenmyinspirationandmyfoundationinlifeAlsotothelightofmylife,myson DanielYouhaveaddedadepthtomylifethatgoesbeyondmerewordsIloveyouandIamproudtobeyourDadFinally,tomysisterSonia, who,fromthetimeIwasborn,wasalwaysthereforme

TomasBGarcia,MD

DrTomasBGarciareceivedhisundergraduatedegreefromFloridaInternationalUniversityWhileapplyingtomedicalschool,DrGarciawas licensedandpracticedasanEMTinthestateofFloridaDrGarciareceivedhismedicaldegreefromtheUniversityofMiami Hecompletedhis internshipandresidencyatJacksonMemorialHospitalinMiami,FloridaandsubsequentlyreceivedboardcertificationinbothInternalMedicine andEmergencyMedicineDrGarciataughtandpracticedintheEmergencyDepartmentsoftheBrighamandWomen’sHospital/Harvard MedicalSchoolinBoston,MassachusettsandGradyMemorialHospital/EmoryMedicalSchoolinAtlanta,GeorgiaHismainareaofinterestis emergencycardiaccareandhelecturesnationallyontopicsrelatedtotheseissues

Foreword

Electrocardiography:TheArtofInterpretation

Ismedicineanartorascience?ThatquestionhasbeenaskedthousandsoftimesinthepastandcontinuestobeaskedtothisdayIthinkthe answerliessomewhereinthemiddleItisbothanartandascienceWeusesciencetogiveussomeobjectiveanswers,drugs,tools,andto provefactsThescienceofmedicinecanbelearnedbyanyoneandrequiresonlyhardworkandperseveranceItistheartofmedicine,however, whichhastobefelt,loved,nurtured,andfinallyacceptedifwearetobecomegoodclinicians

WhenIteachmedicalstudentsphysicaldiagnosis,theyspendthefirstcoupleofweeksmerelyobservingpatientsfromafarTheyarenottotalkto thepatientsortoexaminethemTheironlydutyistoansweronesimplequestion:Isthepatientsickornotsick?Theyonlyhaveabout10to15 secondstomakeuptheirmindssotheycannotrationalizetoomuchTheirdecisionhastobemadefromthegut,basedoninformationthatthey gainedthroughobservationeitherconsciouslyorunconsciouslyItsoundscomplicatedandyetstudentsamazemewithhowquicklytheylearnthis taskandhoweffectivelytheycanputtheselessonstouseThisinternaldecisionmakerisaninnatepartofusallandwillneversteeryouwrong Allwehavetodoistodevelopit

SowhatdoesthishavetodowithECGs?Simple wearegoingtousethesameapproachtolearnelectrocardiography Theonlywaytolearn electrocardiographyistolookatthousandsofECGsandanswerthequestion,“sickornotsick”MostbooksaboutECGsforgetthisonesimple factandinsteadgoonforpagesandpageswritingabouttheECGsandvariationsthatcanbeseen,followedbyoneexampleECGfindingsare notasuniqueasfingerprints,buttheydovaryfrompersontopersonIfyouonlyseeonesampleECGforeachpathologybutneverseethepicture perfectexampleagaininyourlife,youwillneverbeabletodiagnoseit

ThecomplexlanguagethatisusedinelectrocardiographycanbeconfusingandoverwhelmingMostpeoplebuyanadvancedtextbookon electrocardiography,begintoreadit,andthenquicklygiveupSoundfamiliar?Youhavetobeverycompetentatelectrocardiographytobeable tounderstandthewrittenworddescribingthepossiblevariationsThesimplewaytolearnaboutECGsandonethathasbeenlargely underutilizedistoseevariousexamplesandtodevelopafeelforwhatyouarelookingatAfterawhile,youwillbegintofeelyourguttellingyou whetherthepatientis“sickornotsick”TheprocessoflearningtointerpretECGsisnotunlikelearningtothrowaballYoucanreadaboutthe throw,thetrajectories,thespin,andtheaccuracy,butunlessyouseeafewballsthrownandthrowhundredsorthousandsyourself,youwillnever reallylearnknowhowtothrowaballInthesameway,youneedtoseehundredsofECGsbeforeyoubecomecomfortableBythetimeyoufinish thisbook,youwillfeellikeyouarebeginningtounderstandtheterminologyandtheconceptsAfteryourereadthisbook,youwillfeelvery comfortable

YouneedtorememberthatspecificfindingscanrepresentvariousdiseaseprocessesFromthatlistofpotentialdiseases,youwilldevelopalist ofdifferentialdiagnosesforeachproblemfoundontheECGWewillteachyouhowtodiagnosebiatrialenlargement,rightventricular hypertrophy,andright-sidedstrainWewillgiveyouthebackgroundnecessarytodiagnoseseveremitralstenosis,butitwillbeuptoyoutotalkto thepatientandtoexaminethemtodetermineifthisisanaccuratediagnosisThisisbecauseyouneedreal-timeinterpretationandareallive patienttobecompletelycorrectwhenyouinterpretanECGForexample,itisdifficultsometimestointerpretmildSTsegmentelevationinV1 andV2inapatientwithhypertensionIsitleftventricularhypertrophy(LVH)withstrainorisitaninjury?TherearecertaincriteriaforLVHwith strain,butoccasionallythisisnotasclear-cutasitmayseemWell,theanswerismadesimplerifyouhavethepatientinfrontofyouIfthepatient isvisitingyoubecausetheystubbedtheirtoe,it’sprobablyLVHwithstrainIfthepatientisdiaphoreticandclutchinghischest,thediagnosismost likelywouldbeischemiaandinjuryThiscanalsoworkinreverse,ie,anECGcanguideyourexamanddiagnosisTherehavebeenmanytimes whenIhavebeenshownanECGandIhavetoldthecliniciantogobackandpickupsomeinterestingfindingonphysicalexaminationAgood exampleisaventricularaneurysmTheECGwillinformyouofthepresenceoftheaneurysmandtheaneurysmalheaveonphysicalevidencewill confirmdiagnosis

WhenyouinterpretECGs,youhavetobeabletoputtheknowledgethatyouhavegainedfrominterpretationoftheECGandtranslateittoyour patientAlloftheECGsinthisbookwereobtainedfromrealpatientsTheinterpretationsthatwewillofferaretheinterpretationswemadebythe patients’bedsidesYoucandisagreewithsomeofthemandthat’sokayTherearealotofhardandfastrulesinelectrocardiography,buthowyou interpretanECGwilldependonhowyouweretaughtandyourmoodatthetimeyouinterprettheECGYoucanask20cardiologiststheir opinionsonanECGandyouwouldprobablygetalotofdifferentanswersIfyoushowthemthesameECGthenextday,youwouldprobablyget moredifferentinterpretationsfromthesamegroupWhenitcomestointerpretation,peoplejustdon’tseemtoagreeonmuchThekeyisto understandtheconceptswearetryingtoofferyousothatyoucanusetheminyoureverydaypracticeAnECGwillofferyouawealthof knowledgeaboutapatientItcantellyouabouttheirpastandtheirfuture(prognosis)Itcantellyouabouttheirelectrolyteproblems,systemic illnesses,andtheiranatomyNotbadforasimplebedsidetest

Ihavebeenaskedbyafewhundredstudentstoteachthemwhattheyreallyneedtoknow.Icansumuptheanswerinoneshort,concise statement:YouneedtoknowthechangesthatyourspecificpatientpresentedyouontheirECG!Youneverknowwhatwillbeimportantatanyone pointinyourcareer;anyonefactcancostthepatienttheirlifeandwillcostyoucountlesshoursofguilt,andpossiblymillionsofdollars! ElectrocardiographicinterpretationisthesamewhetheranEMT,paramedic,nurse,resident,attendingphysician,orcardiologistperformsit.You cannotlearnjustenoughtogetby.Doesaparamedicoranurseneedtoknowthechangesofhyperkalemiathatcanleadtoalethalarrhythmia? Doesaresidentneedtoknowthatanaxisshiftcanbeasignificantsignofcardiacdiseaseorofaheartattack?Towhomisitmoreimportantto knowthatanacutebifascicularblockbreaksdownintocompleteheartblockandpossiblyasystoleinthesettingofischemia?Itisimportantto you!

Wearegoingtohelpyouunderstandthebasicsofelectrocardiography,thescienceWearegoingtoteachyouusingaprogrammedlearning systemthat,wefeel,willmakeiteasyforyoutolearnatyourownpaceDon’ttrytodoeverythingatonce,becauseitwilloverwhelmyouWhen youarefirststartingout,sticktotheLevel1(blue)material,whichcontainsthebasicteachingpointswrittenforbeginners(seepiv,HowtoUse ThisBook)Asyouadvance,youcangobackandreadthemoreintermediateandadvancedteachingpointsatyourownpaceThisisabook thatismeanttobeusedoverandoveragainuntilyouhaveprogressedthroughallthreelevelsEachtimeyouuseityouwillfindsomeadditional pearls

Inclosing,IwouldliketostatethatyouneedtolookateverythingatyourdisposalandtrustyourselfwhenyouareinterpretinganECG Don’tlet anyonetalkyououtofsomethingthatyouknowistrue JustsmileatthemanddowhatisbestforthepatientYouwillnotgowrong RememberthatanexpertissomeonewhoknowsonemorefactthanyoudoHowever,thatonefactmaynotberelevanttoyourcasesoyoumay bethetrueexpert!

PART1

TheBasics

Part1coversECGbasicsMostoftheboxesarepresentedasLevel1materialAnyonedealingwithECGsshouldbeextremelyfamiliarwiththe informationinthispartIfyouareanexperiencedclinician,youcanskimovertheinformationbutshouldnotskipoveritcompletelyMakesurethat youunderstandthematerialthoroughlybeforegoingontoPart2

NOTE

PediatricelectrocardiographyisnotcoveredinthistextbookduetotheextensiveamountofmaterialrequiredtocoverthistopicThereaderis referredtoatextbookonthespecificsubjectofpediatricelectrocardiography

HowtoReadanECG

ThemajorityofthisbookisgearedtowardbreakingdownthevarioussectionsoftheECGanditscomplexesThechaptersteachyouwhateach partoftheECGrepresentsandtherespectiveabnormalitiesEachsectioncoversthepathologyassociatedwithawaveorintervaloftheECGby usingaproblems-orientedapproachthatconsistsofexaminingthelistofpossiblecausesforapathologicalwaveorintervalanddetermininghow theserelatetotheothercomplexesThislistofpossiblecausesiscalledthedifferentialdiagnosis

AsyoureviewtheECG,lookateachwaveandintervalandcreatelistsofabnormalitiesthatyoufindinthemYouwillthenhaveseverallistsFind outwhatdiseasesorsyndromesarecommontoallofthoselists;thatdiseaseorsyndromewillbe,withalmostcompletecertainty,thediagnosis Beforeyoustartthebook,wewouldliketoofferthefollowingstepstoguideyouinECGinterpretationThesestepswillbecomesecondnature afterreviewanduseDon’tworryifyouareunfamiliarwithsomeoftheterminology youwillbecomefamiliarwithitwhenyoureadthechapters ThemostimportanttasknowistodevelopalogicalapproachtoexaminingandinterpretingtheECGYoucanadjustthissystem,asyouneedto, tomatchyourparticularstyle

1. Getageneralimpressionofwhatisgoingonandkeepitforemostinyourmind.

LookattheECGforafewsecondsandseewhatstrikesyouasthemostimportantdetailIsitischemia,arrhythmia,electrolyteproblems,pacer

problems,orsomethingelse?Don’tletthedetailsoverwhelmyou instead,formthebigpicturefirstandkeepitinyourmindasyoumoveonto interprettheECGEventually,youwilllearnhowtobreakdowntheECGandmethodicallyderiveaninterpretation

2 LookattheECGsequentiallyandinminutedetail

ThisisthesecondconceptthatinvolvesallofthestepsbelowWhenstartingout,trytouseanECGthatcontainsarhythmstripatthebottomthat correlateswiththeleadsabove itwillmakeyourlifemucheasierLookatthebeatsIftheylookdifferent,breakthemdownandfigureoutwhich arethenormalbeatsandwhicharetheabnormalbeatsLookatthenormalbeatsfirsttodetermineyourintervals,axis,blocks,etcThenlookat theabnormalbeatsandfigureoutwhatiscausingthemAretheyPACs,PVCs,aberrantconduction,pacedbeats,orsomethingelse?

3. Whatistherate?

• Isitfastorslow?

• Ifitisirregular,whatistherange?

• Whataretheintervals:PR,QRS,QTc,PP,RR?

• Arethereirregularitiesinanyoftheintervals,forexample,PRdepression?

4 Whatistherhythm?

• Isitfastorslow?

• Regularorirregular?

• Groupedorungrouped?

• CanyouseePwaves?Aretheyallthesame?

• Isthereone-to-oneconductionofthePwavestotheQRScomplexes?

• Wideornarrow?

5 Whatistheaxis?

• Whatquadrantdoesitfallinto?

• Whatistheisoelectriclimblead?

• Whereisthetransitionzoneintheprecordials?

• Calculatetheexactaxis(AdvancedcliniciansshouldalsocalculatetheP,T,andSTaxes)

• Doestheexactaxistellyouanything?

6. Isthereanyevidenceofhypertrophy?

• Leftatrial?

• Rightatrial?

• Biatrial?

• Leftventricular?

• Rightventricular?

• Biventricular?

• Leftorrightstrainpattern?

7. Isthereanyevidenceofischemiaorinfarction?

• ArethereregionalTwaveabnormalities?

• ArethereregionalSTsegmentabnormalities?•ArethereregionalQwaves?

8 HowcanIputitalltogether?

ThinkofallthefindingsandtrytocomeupwithacommonthemetothedifferentialdiagnosisthatyouhavedevelopedThinkofeverythingand overlooknothingBesuretoconsidertherate,rhythm,axis,hypertrophy,intervalabnormalities,blocks,andSTandTwaveabnormalities

9. CanIputitalltogetherwithmypatient’ssignsandsymptoms?

DothediagnosisandfindingsontheECGmakesensewiththepatient’spresentingsignsandsymptoms?CantheECGbeapresentationofa problemorthecauseofsomepre-existingcondition?Askyourself,“HowcanIusetheinformationtoadequatelytreatthepatient?”

10 Whatismyfinaldiagnosis?

Listyourfinalsinglediagnosisoryourabbreviatedlistofdifferentialdiagnoses

Inclosing,don’tforgetthatittakestimetolearntointerpretECGsSomeoftheconceptswementioninthelistabovemaybeaboveyourlevel now,butnotforlong!Themoreyouusethebook,thebetteryouwillbecomeLastly,havefun!Lifeisshort

GrossAnatomy

SinceyouarelearningECGinterpretationyoulikelyarealreadyfamiliarwithbasicanatomyHowever,areviewisneverabadthing,soweare goingtocoverthebasicanatomyoftheheartandthenconcentrateontheelectricalconductionsystem

Theheartsitsinthemiddleofthechestataslightanglepointingdownward,totheleft,andslightlyanteriorTakealookatFigure1-1

Now,let’slookattheheartitselfFirst,fromananteriorview,andthenincross-section

Figure1-1:Locationoftheheartinthechestcavity

AnteriorView

Therightventricle(RV)dominatestheanteriorview.MostoftheanteriorsurfaceoftheventriclesconsistsoftheRVsurface.Akeypointto rememberisthat,thoughtheRVdominatesthisvisualview,theleftventricle(LV)dominatestheelectricalview.Wewillreviewthisinmoredetail inthechapter,IndividualVectors,whenwediscussvectors

Figure1-2:Anteriorviewoftheheart

TheHeartinCrossSection

Hereisacross-sectionalviewoftheheart(Figure1-3)Inthefollowingsections,wewillcoverthefunctionoftheheartasapumpandreviewthe electricalconductionsystemingreaterdetail

Figure1-3:Cross-sectionalviewoftheheart

TheHeartasaPump

Theheartconsistsoffourmainchambers:thetwoatriaandthetwoventriclesTheatriaemptyintotheircorrespondingventriclesTheleft ventricleemptiesintotheperipheralcirculatorysystem,andtherightventricleemptiesintothepulmonarysystemVeinsbringbloodtotheheart, whilearteriestakebloodawayfromtheheartAsFigure1-4shows,thisisaclosedsystemBloodcirculatesinsidethisclosedsystemoverand over,takingupoxygeninthelungsandgivingituptotheperipheraltissuesThisisasimplisticexplanationofaverycomplicatedsystem,butit willsufficeforourpurposesatthistime

Figure1-4:Theheartasapump

PumpFunctionSimplified

Itissimplesttothinkofthecirculatorysystemasanengineerwould:asystemofinterconnectedpumpsandpipes

TakealookatFigure1-5

WeseethattherearefourpumpsinsequenceThetwosmallprimerpumpsaretheatria,whosesolepurposeistopushasmallamountofblood intothetwolargerones,theventriclesTheventriclesdifferinsizeandintheamountofpressurethattheycangenerateBecauseoftheone-way valvesfoundinthevenoussystem,bloodcanonlyflowforward

Figure1-5:Simplifiedpumpfunctionofthecirculatorysystem(Bluerepresentsdeoxygenatedblood;redrepresentsoxygenatedblood)

TheElectricalConductionSystem

TheelectricalconductionsystemoftheheartismadeupofspecializedcellsSomeofthesearespecializedforpacemakingfunctionsandsome forthetransmissionoftheimpulsesthattravelthroughthemWewillbreakdownthesysteminthefollowingparagraphsanddescribethe functionsofeachofthepartsingreaterdetail

ThemainfunctionofthesystemistocreateanelectricalimpulseandtransmititinanorganizedmannertotherestofthemyocardiumThisisan electrochemicalprocessthatcreateselectricalenergythatispickedupbytheelectrodeswhenweperformanelectrocardiogram(ECG)(More onthisinthechapter,IndividualVectors)

Figure1-6:Theelectricalconductionsystem

Thespecializedconductionsystemisinterwovenwiththemyocardialtissueitselfandisonlydistinguishablewithcertainstainsundera microscopeSoinlookingatFigure1-7,keepinmindthatthesystemisactuallyintheheartwallsTheatrialmyocytesareinnervatedbydirect contactfromonecelltoanother;thefirstcellinnervatesthesecond,thesecondinnervatesthethird,andsoonTheinternodalpathwaystransmit theimpulsefromthesino-atrial(SA)nodetotheAVnodeThePurkinjesystemencirclestheentireventricles,justundertheendocardium,andis thefinalcomponentoftheconductionsystemThePurkinjecellsinnervatethemyocardialcellsthemselves

Figure1-7:Theelectricalconductionsystemoftheheart

PacemakerFunction

Whatisthepacemakerfunctionoftheheart,andwhydoweneedit?Thepacemakerdictatestherateatwhichtheheartwillcyclethroughits pumpingactiontocirculatethebloodThepacemakercreatesanorganizedbeatingofallofthecardiaccells,inaspecializedsequence,to produceeffectivepumpingactionItsetsthepacethatalloftheothercellswillfollowLet’slookatananalogy

ImaginethateachcelloftheheartrepresentsasinglemusicianWhenwehaveafewdozenofthesemusicians,wehaveanorchestra the heartNow,ifeachmusiciandecidestoplaywheneverheorshewantsto,theywouldmakeanunrecognizablejumbleofsoundThemusicians needabeatorsignaltocuethemwhentostarttoplay,directthemwhentocomeintothepieceandwhentoleave,andcoordinatetheiractionsto createabeautifulmelodyInmusic,thatpacemakeristheunderlyingbeatkeptbythedrummerortheconductorInsectionsthatareswift,the beatincreasesInsectionsthatareslowandsoft,thebeatdecreasesThesamethinghappensintheheart;duringexercisethepacespeedsup, andduringrestitslows

Aswehavementioned,therearespecializedcellswhosefunctionistocreateanelectricalimpulseandactastheheart’spacemakerThemain areathatfillsthisimportantfunctionistheSAnode,foundinthemuscleoftherightatriumThisarearespondstotheneedsofthebody, controllingthebeatbasedoninformationitreceivesfromthenervous,circulatory,andendocrinesystemsThemainpacemakerpacesatarate of60to100beatsperminute(BPM),withanaverageof70

PacemakerSettings

Onethingweknowaboutthebodyisthateverythinghasabackup.Everycellintheconductionsystemiscapableofsettingthepace.However, theintrinsicrateofeachtypeofcellisslowerthanthecellsthatprecedeit.ThismeansthatthefastestpaceristheSAnode,thenextfastestisthe AVnode,andsoon.Thefastestpacersetsthepacebecauseitcausesalltheonesthatcomeafterittoresetaftereachbeat.Inthisway,the slowerpacerswillneverfire.Ifthefasterpacerdoesn’tfireforsomereason,thenextfastestwillbethereasabackuptoensurefunctionthatisas closetonormalaspossible.

Figure1-8:Intrinsicratesofpacingcells

TheSinoatrial(SA)Node

TheSAnode,theheart’smainpacemaker,isfoundinthewalloftherightatriumatitsjunctionwiththesuperiorvenacavaItsbloodsupplycomes

fromtherightcoronaryarteryin59%ofcasesIn38%,thebloodsupplyoriginatesfromtheleftcoronaryartery,andinthelast3%,itarisesfrom both

Figure1-9:SAnode

TheInternodalPathways

Therearethreeinternodalpathways:anterior,middle,andposterior.TheirmainpurposeistotransmitthepacingimpulsefromtheSAnodeto theAVnode.Inaddition,thereisasmalltractofspecializedcellsknownastheBachmannbundlethattransmitstheimpulsesthroughtheinteratrialseptumAllofthesepathwaysarefoundinthewallsoftherightatriumandtheinter-atrialseptum

Figure1-10:Internodalpathways

TheAtrioventricular(AV)Node

TheAVnodeislocatedinthewalloftherightatriumjustnexttotheopeningofthecoronarysinus,thelargestveinoftheheart,andtheseptal leafletofthetricuspidvalveItisresponsibleforslowingdownconductionfromtheatriatotheventriclesjustlongenoughforatrialcontractionto occurThisslowingallowstheatriato“overfill”theventriclesandhelpsmaintaintheoutputoftheheartatamaximumlevelTheAVnodeisalways suppliedbytherightcoronaryartery

AVnode

TheBundleofHis

TheBundleofHisstartsattheAVnodeandeventuallygivesrisetoboththerightandleftbundlebranchesItisfoundpartiallyinthewallsofthe rightatrium,andintheinterventricularseptumTheHisbundleistheonlyrouteofcommunicationbetweentheatriaandtheventricles

Figure1-12:BundleofHis

TheLeftBundleBranch(LBB)

TheleftbundlebeginsattheendoftheHisbundleandtravelsthroughtheinterventricularseptumTheleftbundlegivesrisetothefibersthatwill innervatetheLVandtheleftfaceoftheinterventricularseptumItfirstconnectstoasmallsetoffibersthatinnervatetheuppersegmentofthe interventricularseptumThiswillbethefirstareatodepolarize,meaningthattheheart’scellsfireTheleftbundleendsatthebeginningoftheleft anterior(LAF)andleftposteriorfascicles(LPF)

Figure1-11:

Figure1-13:Leftbundlebranch(LBB)

TheRightBundleBranch(RBB)

Therightbundle,whichalsostartsattheHisbundle,givesrisetothefibersthatwillinnervatetheRVandtherightfaceoftheinterventricular septumItterminatesinthePurkinjefibersassociatedwithit

Figure1-14:Rightbundlebranch(RBB)

TheLeftAnteriorFascicle(LAF)

TheLAF,alsoknownastheleftanteriorsuperiorfascicle,travelsthroughtheleftventricletothePurkinjecellsthatinnervatetheanteriorand superioraspectsoftheleftventricleItisasingle-strandedfascicle,incomparisontotheLPF

Figure1-15:Leftanteriorfascicle(LAF)

TheLeftPosteriorFascicle(LPF)

TheLPFisafan-likestructureleadingtothePurkinjecellsthatwillinnervatetheposteriorandinferioraspectsoftheleftventricle.Itisverydifficult toblockthisfasciclebecauseitissowidelydistributed,ratherthanbeingjustonestrand.

Figure1-16:Leftposteriorfascicle(LPF)

ThePurkinjeSystem

ThePurkinjesystemismadeupofindividualcellsjustbeneaththeendocardium.Theyarethecellsthatdirectlyinnervatethemyocardialcellsand initiatetheventriculardepolarizationcycle.

Figure1-17:Purkinjesystem.

REMINDER

Sothatthepathologythatwewillpresentintherestofthebookcanbeunderstood,itiscriticaltounderstandtheheart’selectricalconduction systemThispathologycoversaberrantlytransmittedbeats,bundleblocks,fascicularblocks,AVblocks,andrhythmdisturbancesWesuggestat thispointthatyougobackoverthesystemafewtimesuntilyouarefamiliarwithitscomponentsandthewaythatthepacedelectricalimpulse travelsthroughtheheart

ThisismeanttobeacursoryreviewofcardiacandconductionsystemanatomyWewillspendmoretimeonvariousaspectsofthesystemaswe discusstheindividualpathologicstatesForamoreextensivereviewofthesubject,trythebooksmentionedintheAdditionalReadingssection

CHAPTERINREVIEW

1. Visually,therightventricledominatestheanteriorviewoftheheart.TrueorFalse.

2 TherightventriclepumpsthebloodthroughtheperipheralcirculationTrueorFalse

3. Whichofthestatementsbelowisincorrect:

A Theelectricalconductionsystemoftheheartismadeupofspecializedcells

B. Theconductionsystemisinterwovenintothemyocardialtissue

C. Theconductionsystemisvisibleunderthemicroscopewithoutspecialstains

D TheinternodalpathwaystransmittheimpulsebetweentheSAnodeandtheAVnode

Matchthefollowingcorrectly:

4. SAnode

5 Atrialcells

6. AVnode

7. Hisbundle

8. Purkinjecells

9. Myocardialcells

10. TheAVnodeisalwayssuppliedby:

A Theleftanteriordescendingartery

B. Theposteriordescendingartery

C Therightcoronaryartery

D. Theleftcircumflexartery

E. Thefirstdiagonalartery

40–45BPM

30–35BPM

60–100BPM

20–40BPM

55–60BPM

45–50BPM

Whydoyouneedtoknowaboutthegenerationofelectricalactivityinacellandtheeffectofelectrolytesontheelectrocardiogram(ECG)?

BecausebeforeyoucanunderstandwhatanECGdoes,youneedtoknowhowitgetsitsinformationElectrolytesarethemeansbywhichthecell develops“electricity”Youalsoneedtoknowaboutelectrolytesbecauseimbalancescancauselife-threateningproblemsForexample,ifyou knewthatpeaked,sharpTwaveswereasignofhyperkalemia(elevatedpotassium),orthataprolongedQTintervalcouldbeasignof hypocalcemiaorhypomagnesemia,youmightavertaseriousarrhythmiaIttakesonlyminutesinsomecasestogofrompeakedTwavesto asystole(Bytheway,pacersdonotworkinhyperkalemia!)AlittleknowledgeaboutelectrolytesandtheireffectsontheECGpatternscansave thepatient andyou

TounderstandwhytheECGisalteredbyanelectrolyteabnormality,wewillreviewthewayinwhichthemyocardialcellbecomespolarizedand depolarized,andthebiochemicalmechanismsthatallowthecelltocontractWewilltrytomaketheconceptsaspainlessaspossible,sobear withusThisisintendedtobeonlyaverybasicdiscussionofthetopic,whichyoucansupplementwithagoodphysiologytextbookasneeded

MechanicsofContraction

Imaginethattheheartismadeupofaseriesofsmallbarrelsorcells(Figure2-1)Eachofthesebarrelsismadeupoftwohalvesthatslideover eachotherandareheldtogetherbyinterlockingpieces(actinandmyosinproteins)Theactinmoleculesareattachedtotheoutsideedgesofthe barrelwall,andthemyosinmoleculesareinterspersedbetweentheactinmolecules

Figure2-1:Myocardialcell(myocyte)

Theoutsidesofthebarrels(cells)arefusedtogethertoformlongbands,ormyofibrils(Figure2-2)Thesebands,inturn,areheldtogetherside-tosidebywire(connectivetissue)toformsheets,whicharecoveredwithfluid(extracellularfluid)Themainfunctionofthebandsistocontractand expandWhenoneofthebarrelscontracts,thewholesheetshortensbyasmallamountWhenallofthebarrelscontract,thewholesheetshortens significantlyThesheetreturnstoitsstartingsizeasallofthebarrelsrelaxThesheetsarearrangedtoformthefoursacsthatconstitutetheheart: twosmall,thinonesontop(theatria)andtwolarge,thickonesonbottom(theventricles)

Figure2-2:Barrelsareheldtogether,formingmyofibrilsandsheets

IonMovementandPolarity

Thefluidinsideandoutsideofthebarrelcontainswater,salts,andproteinsThefluidsarenotthesame,however;theconcentrationsofsalt moleculesandproteinsaredifferentineachoneInliquids,saltsbreakdownintopositivelyandnegativelychargedparticlesknownasions (Figure2-3)Inotherwords,anionisapositivelyornegativelychargedparticleinasolutionInthebody,themainpositivelychargedionsare sodium(Na+),potassium(K+),andcalcium(Ca++)Chloride(Cl)isthemainnegativelychargedion

Figure2-3:Saltsinaliquidmediumturnintopositivelyandnegativelychargedions

Ifthecellwerenotalive,theconcentrationsofalloftheionsandchargeswouldbethesameonbothsidesofthebarrelwall(thecellmembrane) However,alivecellmaintainsdifferencesintheseconcentrationsacrossthecellmembrane(Figure2-4)Theinsideofthecellhasahigher potassiumconcentration,whereastheoutsidehasahigherconcentrationofsodiumThehigherpositivechargeoutsidethecellthuscauses relativelymorenegativechargeinsidethecellTheoutsideofthecellwallalsohasmorecalcium,whichaddstothegreaterpositivecharge outsidethecellThisdifferencebetweenthechargesoutsideandinsideofthecellwallisknownasitselectricalpotential

ChargesandionsnaturallywanttocancelthemselvesoutandmaintainneutralityThecellwallisnotacompletelyimpermeablemembraneItis semi-permeable,becauseitcontainssmallleaksthatletsomeoftheionsintoandoutofthecellThenaturaltendencyisforsodiumtoenterand potassiumtoexitTomaintainanelectricalpotential,thecellmusthavesomewayofpushingtheionsaroundagainsttheirwishesEnterthe sodium-potassiumATPasepumps(bluedotsinfigures)Thepumpsactivelymoveionsaroundtomaintaintherestingconcentrationandcharge ofthecellNow,howdoesthepumpdothat?ThepumpusesATP,thebody’sfuelpellet,topushoutthreesodiumions(threepositivecharges) andbringintwopotassiumions(twopositivecharges)TheresultisagreaternumberofpositivechargesoutsidethebarrelthaninsideInother words,theoutsidesolutionhasapositivecharge,whiletheinnersolutionhasamorenegativechargeBecauseofthispumpingaction,the electricalpotentialoftherestingmyocyteisapproximately 70to 90mV

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