Unlocking The Power Of Cellular Health For MS Support

The Wahls™ Paleo Diet Level 2 Cheat Sheet

Eat recommended foods according to your appetite.

6 to 12 oz. / 2x week

Get Involved in a Clinical Trial

For many, being in a clinical trial provides additional motivation to make and sustain dietary improvements. Having one family member in a diet study often helps the whole family improve their diet. Consider being in one of our upcoming trials today. Being in a clinical trial motivates us to improve other health behaviors. We do more exercise. We pay attention to our sleep and stress management strategies. It often helps the whole family take better care of themselves. Look over the list of trials and join a study today.

Changing the standard of care

Help us change the standard of care for people with chronic disease so they will be told that improving diet and other wellness behaviors is an important part of managing their illness. We need people like you to participate in a clinical trial to build the evidence

that changing what we eat, and our self-care routines can impact symptoms and improve quality of life.

Autoimmune And Other Chronic Health Conditions Registry

This is a patient registry for people with a variety of chronic health conditions. These conditions include optic neuritis, radiologically isolated syndrome, clinically isolated syndrome, multiple sclerosis, other neuroimmune conditions, other neurological conditions, other autoimmune conditions, mental health conditions, high blood pressure, obesity, high cholesterol, prediabetes, diabetes, insulin resistance, metabolic syndrome, heart disease, infertility, and other chronic diseases. We will periodically invite people in this registry to participate in future observational and interventional studies in the setting a variety of chronic disease states.

New Populations for a Study of an Online Wellness Program

While the study of MS patients is complete, we have added two new populations to our online wellness program study (NCT05057676).

We are inviting people with fibromyalgia or post-acute sequela of COVID 19 (also known as long COVID) to enroll. This study evaluates whether access to an online wellness course leads to reduced symptoms and improved quality of life in these conditions. You must be an adult and live in North America to participate in this online-only study.

Fibromyalgia Patients: If you have fibromyalgia, complete this survey to see if you are eligible to participate.

Post-acute sequela of COVID-19 Patients: If you have post-acute sequela of COVID-19, complete this survey to see if you are eligible to participate.

ABOUT DR. WAHLS

She conducts clinical trials that test the effect of nutrition and lifestyle Interventions to treat MS and other progressive health problems. She also teaches the public and medical community about the healing power of the Paleo diet and therapeutic lifestyle changes that restore health and vitality to our citizens. She hosts a Wahls Protocol® Seminar every August where anyone can learn how to implement the Protocol with ease and success.

CHANGING THE STANDARD OF CARE THROUGH PHILANTHROPIC SUPPORT FOR INNOVATIVE RESEARCH

Q: What will it take to change the Standard of Care for patients who are diagnosed with a neuroimmune condition?

A: A vision, a goal, a track record of success and an investment from those who care.

THE VISION

When all patients diagnosed with a neuroimmune condition will be told that it is vital to address diet and lifestyle as part of their treatment plan.

THE GOAL

Relentless pursuit of groundbreaking research and randomized controlled trials by a team of dedicated professionals lead by an expert in the field.

This brochure reviews the various types of projects and support that can help drive forward progress in changing the standard of care for multiple sclerosis and neuroimmune patients.

TRACK RECORD OF SUCCESS

2022 PUBLICATIONS

Dietary Approaches to Treating Multiple SclerosisRelated Symptoms Facilitators

frontiers

Opinion: The Role of the Registered Dietitian Nutritionist in Mu ltipl e Sclerosis Care

Tyler J Titcomb' " , Mona Bostick', Ahmed Z Obeidat-'

Neurology·

The most widely read and highly cited peer-reviewed neurology journal

Home Lat est Articles Current Issue Past Issues Residents & Fellows October

Editorial > Neurology. 2022 Oct 18;10.1212/WNL.0000000000201565. dOi: 10.1212/WNL.0000000000201565. Onfo,e ahead of pmt.

The Role of Diet in Multiple Sclerosis: Food for Thought

Rebecca Span 1 2 , Laura Ptc:cio 3 •, Annette M Langer-Gould s

Efficacy of Diet on Fatigue and Quality of Life in Multiple Sclerosis:

A

Systematic Review and Network Meta-analysis of Randomized Trials

IMPACT ON THE FIELD

Linda Snetse laar, Joshua JCheek, Sa r a Shuger Fox., 8 Heather S Healy, Marin L. Schweizer, Wei Bao.John Kamholz, e Tyter JTitcomb

PUBLISHED PAPERS

Wahls TL. Telling the world. Ann Intern Med 2008;149(1):61-62. PMID: 18591640

Reese D, Shivapour ET, Wahls TL, et al. Neuromuscular electrical stimulation and dietary interventions to reduce oxidative stress in a secondary progressive multiple sclerosis patient leads to marked gains in function: a case report. Cases J 2009;2:7601. PMCID: PMC2769364

Wahls TL. The seventy percent solution. J Gen Intern Med 2011;26(10):1215-1216. PMCID: PMC3181302

Bisht B, Darling WG, Grossmann RE, et al. A multimodal intervention for patients with secondary progressive multiple sclerosis: feasibility and effect on fatigue. J Altern Complement Med. 2014;20(5):347-355. PMCID: PMC4011484

Wahls T, Rubenstein L, Hall M, Snetselaar L. Assessment of dietary adequacy for important brain micronutrients in patients presenting to a traumatic brain injury clinic for evaluation. Nutr Neurosci 2014;17(6):252-259. PMID: 24074905

Bisht B, Darling WG, Shivapour ET, et al. Multimodal intervention improves fatigue and quality of life in subjects with progressive multiple sclerosis: a pilot study. Degener Neurol Neuromuscul Dis 2015;5:19-35. PMCID: PMC6361513

Bisht B, Darling WG, White EC, et al. Effects of a multimodal intervention on gait and balance of subjects with progressive multiple sclerosis: a prospective longitudinal pilot study. Degener Neurol Neuromuscul Dis 2017;7:79-93. PMCID: PMC6053103

Irish AK, Erickson CM, Wahls TL, et al. Randomized control trial evaluation of a modified Paleolithic dietary intervention in the treatment of relapsing-remitting multiple sclerosis: a pilot study. Degener Neurol Neuromuscul Dis 2017;7:1-18. PMCID: PMC6053098

Lee JE, Bisht B, Hall MJ, et al. A multimodal, nonpharmacologic intervention improves mood and cognitive function in people with multiple sclerosis. J Am Coll Nutr 2017;36(3):150-168. DOI: 10.1080/07315724.2016.1255160

Wahls T, Scott MO, Alshare Z, et al. Dietary approaches to treat MS-related fatigue: comparing the modified Paleolithic (Wahls Elimination) and low saturated fat (Swank) diets on perceived fatigue in persons with relapsing-remitting multiple sclerosis: study protocol for a randomized controlled trial. Trials 2018;19(1):309. PMCID: PMC5987638

Chenard CA, Rubenstein LM, Snetselaar LG, et al. Nutrient composition comparison between the low saturated fat Swank diet for multiple sclerosis and healthy U.S.-style eating pattern. Nutrients 2019;11(3):616. PMCID: PMC6470969

Chenard CA, Rubenstein LM, Snetselaar LG, Wahls TL. Nutrient composition comparison between a modified Paleolithic diet for multiple sclerosis and the recommended healthy U.S.-style eating pattern. Nutrients 2019;11(3) :537. PMCID: PMC6470485

Fellows Maxwell K, Wahls T, Browne RW, et al. Lipid profile is associated with decreased fatigue in individuals with progressive multiple sclerosis following a diet-based intervention: results from a pilot study. PLoS One 2019;14(6):e0218075. PMCID: PMC6581256

Zhang Y, Chhonker YS, Bala V, et al. Reversed phase UPLC/APCI-MS determination of vitamin K(1) and menaquinone-4 in human plasma: application to a clinical study. J Pharm Biomed Anal 2020;183:113147. PMID: 32086127

Lee JE, Titcomb TJ, Bisht B, et al. A modified MCT-based ketogenic diet increases plasma beta-hydroxybutyrate but has less effect on fatigue and quality of life in people with multiple sclerosis compared to a modified Paleolithic diet: a waitlist-controlled, randomized pilot study. J Am Coll Nutr 2021;40(1):13-25. PMID: 32213121

Titcomb TJ, Brooks L, Smith KL, et al. Change in micronutrient intake among people with relapsing-remitting multiple sclerosis adapting the Swank and Wahls diets: an analysis of weighed food records. Nutrients 2021;13(10).3507. PMCID: PMC8540533

Wahls T, Titcomb T, Bisht B, et al. Patient empowerment and the exclusion of dietary intervention studies. Comment on "Diet and Multiple Sclerosis: Scoping Review of Web-Based Recommendations." Interact J Med Res 2021;10(1):e17063. PMCID: PMC7929754

Wahls TL, Titcomb TJ, Bisht B, et al. Impact of the Swank and Wahls elimination dietary interventions on fatigue and quality of life in relapsing-remitting multiple sclerosis: the WAVES randomized parallel-arm clinical trial. Mult Scler J Exp Transl Clin 2021;7(3):20552173211035399. PMCID: PMC8326636

Dean C, Parks S, Titcomb TJ, et al. Facilitators of and barriers to adherence to dietary interventions perceived by women with multiple sclerosis and their support persons. Int J MS Care 2022;24(5):235-241. PMCID: PMC9461720

Elliott-Wherry AN, Lee JE, Pearlman AM, et al. The Wahls Behavior Change Model for complex chronic diseases: a clinician's guide. Degener Neurol Neuromuscul Dis 2022;12:111-125. PMCID: PMC9469801

Titcomb TJ, Bao W, Du Y, Liu B, Snetselaar LG, Wahls TL. Association of multiple sclerosis with risk of mortality among a nationally representative sample of adults in the United States. Mult Scler J Exp Transl Clin 2022;8(2):20552173221104009. PMCID: PMC9158421

Villa AT, Tu BH, Titcomb TJ, et al. Association between improved metabolic risk factors and perceived fatigue during dietary intervention trial in relapsing-remitting multiple sclerosis: a secondary analysis of the WAVES trial. Front Neurol 2022;13:1022728. PMCID: PMC9892773

Wahls TL. Dietary approaches to treating multiple sclerosis-related symptoms. Phys Med Rehabil Clin N Am 2022;33(3):605-620. PMID: 35989054

Titcomb TJ, Liu B, Wahls TL, et al. Comparison of the ketogenic ratio of macronutrients with the low-carbohydrate diet score and their association with risk of type 2 diabetes in postmenopausal women: a secondary analysis of the Women's Health Initiative. J Acad Nutr Diet 2023;123(8):1152-1161.e4. PMCID: PMC10279805

Plafker SM, Titcomb T, Zyla-Jackson K, et al. Overview of diet and autoimmune demyelinating optic neuritis: a narrative review. Immunometabolism (Cobham) 2023;5(2):e00022. PMCID: PMC10144304

Shemirani F, Titcomb TJ, Saxby SM, et al. Association of serum homocysteine, folate, and vitamin B(12) and mood following the Swank and Wahls elimination dietary interventions in relapsing-remitting multiple sclerosis: secondary analysis of the WAVES trial. Mult Scler Relat Disord 2023;75:104743. PMID: 37148578

Snetselaar LG, Cheek JJ, Fox SS, et al. Efficacy of diet on fatigue and quality of life in multiple sclerosis: a systematic review and network meta-analysis of randomized trials. Neurology 2023;100(4):e357-e366. PMID: 36257717

Titcomb TJ, Sherwood M, Ehlinger M, et al. Evaluation of a web-based program for the adoption of wellness behaviors to selfmanage fatigue and improve quality of life among people with multiple sclerosis: A randomized waitlist-control trial. Mult Scler Relat Disord 2023;77:104858. PMID: 37399671

Crippes LJ, Saxby SM, ShemiraniF,Bisht B, Gill C, Rubenstein LM, Ten Eyck P, Carr LJ, Darling WG, Hoth KF, Kamholz J, Snetselaar LG,Titcomb TJ, Wahls TL. Diet-induced changes in functional disability are mediated by fatigue in relapsing-remitting multiple sclerosis: A secondary analysis of the WAVES randomized parallel-arm trial. Mult Scler Exp Trans Clin 2023;9(4):20552173231209417. PMCID: PMC10617283

Titcomb TJ, Richey P, Casanova R, Wahls TL et al. Association of type 2 diabetes mellitus with dementia-related and nondementia-related mortality among postmenopausal women: a secondary competing risks analysis of the women's health initiative. Alzheimers Dement 2024;10(1):234-242. PMCID: PMC10916943

Saxby SM, Shemirani F, Crippes et al. Effects of a remote multimodal intervention involving diet, walking program, and breathing exercise on quality of life among newly diagnosed people with multiple sclerosis: a quasi-experimental non-inferiority pilot study. Degener Neurol Neuromuscular Dis 2024;14:1-14. PMCID: PMC10787513

Shemirani F, Pingel WR, Titcomb TJ, et al. The effect of dietary interventions on inflammatory biomarkers among people with multiple sclerosis: A protocol for systematic review and meta-analysis of randomized controlled trials. PlosOne 2024;19(2):e0297510. PMCID: PMC10849228

Saxby SM, Haas C, Shemirani F, et al. Association between improved serum fatty acid profiles and cognitive function during a dietary intervention trial in relapsing-remitting multiple sclerosis. Int J MS Care 2024;26(2):61-68. PMCID: PMC10930804

BOOKS

Minding My Mitochondria, 2nd ed. Iowa City, IA: TZ Press, 2010. ISBN-13: 978-0-9821750-8-8

The Wahls Protocol Cooking for Life: The Revolutionary Modern Paleo Plan to Treat All Chronic Autoimmune Conditions. New York, NY: Penguin Random House, 2017. ISBN: 9780399184772

The Wahls Protocol: A Radical New Way to Treat All Chronic Autoimmune Conditions Using Paleo Principles. New York, NY: Penguin Random House, 2020. ISBN: 978-1-58333-521-5

TRIALS CURRENTLY OPEN TO PATIENTS

Efficacy of Diet on Quality of Life in Multiple Sclerosis (EDQ). University of Iowa Health Care, clinicaltrials.gov (NCT05007483)

Autoimmune Intervention Mastery Course Study (AIM). clinicaltrials.gov (NCT05057676), terrywahls.com

PARTICIPANT REGISTRY

To be notified of open and upcoming studies, please fill out our registration form, found at terrywahls.com/trials

PHILANTHROPIC OPPORTUNITIES

SUPPORT TYPE COST (USD)

• Analysis of banked biospecimens

• Funding for specific research team members $50 - $200 thousand (research intern, PhD student, postdoctoral scholar, study coordinator)

• Pilot studies (new disease or intervention)

• Large randomized trials $250 - $500 thousand

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