The Groundbreaking Discovery of GG For Heart Health
Restores CoQ10 Harmony and Assists With Statin Management
Introducing the Experts
Dr. Joel Kahn
Meet our brand ambassador, Dr. Joel Kahn, MD. FACC, otherwise known as āAmericaās Healthy Heart Doctorā.
He is one of the world's leading cardiologists, a clinical professor of medicine, an integrative medicine practitioner and promoter of plant-based nutrition. He is a holistic cardiologist who strongly believes in the power of nutrition and supplements to help reduce disease risk, improve markers of heart health, and balance out dietary insufficiencies.
Dr. Joel Kahn has been an enormous asset to Xtendlife and continues his efforts to support in many ways. Dr. Kahn and Xtendlifeās unwavering mission to share good heart health advice, practices and supplements - so everyone can live a healthier, happier and longer life - is precisely why we've come together to design this informative guide to help you on your way to better health for many years to come.
Enjoy!
Dr. Joel Kahn, MD, FACC of Detroit, Michigan, co-host of Reversing Heart Disease Naturally Summit by DrTalks. Dr. Kahn is a practicing cardiologist and Clinical Professor of Medicine at Wayne State University School of Medicine. He has a triple board certification in Internal Medicine, Cardiovascular Medicine and Interventional Cardiology. He was also the first physician in the world to certify in Metabolic Cardiology with A4M/MMI and the University of South Florida.
Dr. Barrie Tan
Dr. Barrie Tan, PhD, American scientist and researcher, solved the problem of how to replenish GG in the body naturally. Dr. Tan is also a world expert on Vitamin E and Tocotrienols.
Dr. Tan has spent his career travelling and searching out solutions to issues that affect the health of our bodies. He was a pioneer in the field of Vitamin E and Tocotrienol research and uncovered a lot of misconceptions in the area of Vitamin E, which everyone should be aware of.
What is GG (Geranylgeraniol)?
Why Do CoQ10, Vitamin K2 and Skeletal Muscle Protein Matter?
- CoQ10 Importance and GG - The Role of Vitamin K2 and GG - Skeletal Muscle Protein and GG
The Remarkable Benefits of GG for Heart and Muscle Health
Uncover GG's pivotal role in managing SAMs - Research About GG - Who Should Take GG?
DrTalks - Heart Health Range Special!
What is GG (Geranylgeraniol)?
Have you ever heard of GG? No, itās not a trendy new acronym. Itās a naturally produced nutrient in your body with amazing health benefits. But thereās a good chance youāre not getting enough of it.
GG stands for geranylgeraniol, a type of lipid involved in the synthesis of several vital compounds in your body, such as coenzyme Q10, vitamin K2, and skeletal muscle proteins. These compounds are essential for maintaining your heart health, bone health, and muscle strength.
But hereās the catch: your GG levels can decline with age or due to certain medications, such as statins, bisphosphonates, and warfarin. This can also lead to reduced coenzyme Q10, vitamin K2 synthesis, as well as muscle loss and weakness - that can mean serious consequences for your health and well-being.
Fortunately, there is a way to restore your GG levels and reap its benefits through supplementation.
Scientists discovered that GG can be naturally derived from annatto, a plant from the Amazon Forest with bright red-orange seeds. Taking GG supplements regularly helps to support GG levels in the body, which further optimizes coenzyme Q10 production, vitamin K2 performance and skeletal muscle protein formation.
The Amazon Rainforest
Why Do CoQ10, Vitamin K2 and Skeletal Muscle Protein Matter?
Many of us recognize CoQ10 (Coenzyme Q10) as the heart's superhero. However, you might be curious about the connection between calcium, muscle protein, and heart well-being. Let's explore together. Firstly, it's crucial to understand a biological process in the body known as the mevalonate pathway. Cholesterol and GG are produced in this pathway at the cellular level, playing a vital role in heart health and beyond. Since CoQ10, vitamin K2, and muscle protein synthesis are also linked to the mevalonate pathway, it implies that cholesterol and GG can influence protein prenylation, impacting the cellular functions of CoQ10 and vitamin K2Ā¹'Ā²'Ā³'ā“ .
We know that elevated cholesterol levels can increase the risk of cardiovascular diseases. However, it's noteworthy that low levels of GG can also affect the health of the mevalonate pathway, consequently influencing CoQ10 levels, calcium deposits, and muscle strength.
The
Normal Healthy Mevalonate Pathway
CoQ10 Importance and GG
CoQ10 is short for Coenzyme Q10, it is a vital element for sustaining life and promoting overall well-being, it's especially crucial for cardiovascular health and energy production.
Low levels of CoQ10 can potentially lead to health issues such as fatigue, muscle pain and weaknessāµ. Factors like age, genetics, nutrition, and medications (statins) can hinder the body's natural CoQ10 production, particularly impacting those with chronic conditions like heart disease.
"People with chronic conditions have notoriously low levels of CoQ10"
Research found that people with chronic conditions such as heart disease and type 2 diabetes have notoriously low levels of CoQ10 in their system[5]. Hence ubiquinol supplementation is often recommended for people to help reduce cardiovascular health risks, especially for patients on statins.
GG is the building block of CoQ10Ā¹, encouraging the natural production of CoQ10 in the body system. Supplementing GG and CoQ10 together can also enhance the bioavailability of CoQ10. Additionally, GG only has a third of the CoQ10 molecular weight, which means it can easily diffuse inside cells and organelles.
GG
Smallest of the "small molecules"
Easy to absorb into cellular membranes
CoQ10
Largest of the "small molecules"
Difficult to absorb & get into membranes
The Role of Vitamin K2 and GG
Vitamin K2 plays a crucial role in various biological functions, with a primary focus on blood clotting and bone metabolism. Its activation of proteins is essential for directing calcium deposition toward bones and teeth, preventing undesirable accumulation in arteries, and causing arterial calcification6 .
The mevalonate pathway contributes to vitamin K2's efficacy by providing GG (geranylgeraniol), supporting the proper functioning and cellular localization of the activated proteins.
Chemical Structure
CoQ10 Chemical Structure
Skeletal Muscle Protein and GG
When we talk about skeletal muscle protein, we're talking about the superhero of muscles and bones. Skeletal muscle protein is vital for the structural integrity & function of muscles, including overall muscle strength and endurance. These are important for people over 50, especially for those who are on statin drugs. Adequate protein intake and the promotion of muscle protein synthesis are essential for maintaining optimal health and wellbeing.
GG in the mevalonate pathway ā it's like the behind-the-scenes hero, which indirectly influences skeletal muscle protein synthesis through its role in post-translational modifications, supporting muscle growth and function7
The Remarkable Benefits of GG for Heart and Muscle Health
By replenishing natural levels of coenzyme Q10, vitamin K2, and skeletal muscle proteins, GG offers protection against age-related physical decline, maintains structural integrity, and combats muscle fatigue
The effects of GG supplementation are far-reaching. Here are just a few you can expect from adding GG to your health regimen
ā¢ GG supports healthy cholesterol levels and prevents calcium buildup in your arteries, which can lower your risk of heart disease and stroke.
ā¢ GG enhances your heart muscle function and energy production, which can improve your cardiac output and endurance.
ā¢ GG stimulates protein synthesis and prevents muscle wasting, which can increase your muscle mass and strength
ā¢ GG reverses muscle fatigue and weakness, which can improve your physical performance and quality of life. Muscle fatigue and weakness are also common side effects of statin drugs.
ā¢ GG increases your bone mineralization and prevents bone loss, which can reduce your risk of osteoporosis and fractures.
Sounds impressive, right?
Dr. Barrie Tan, a researcher on lipid-soluble nutrients, has conducted several studies on GG and its effects on human health. He has found that GG can restore coenzyme Q10 and vitamin K2 levels in people who take statins, bisphosphonates, or warfarin, and improve their cardiovascular and skeletal health. He has also found that GG can increase muscle protein synthesis and reverse muscle fatigue and weakness in older adults
Uncover GG's Pivotal Role in Managing SAMs*
High cholesterol is a common health concern for many, over 40 million Americans rely on prescription statins to keep it in check. That's a staggering number, and it's not slowing down ā from 2002 to 2012 statin use almost doubled, and it may reach 80 million by 2030.
Statin usage nearly doubled from 2002-2012 40 million Americans currently take statins The number of statin users is expected to double again in the next 10 years.
However, a significant chunk of statin users are facing some hiccups. Why? Because statins interfere with the production of GG in the mevalonate pathway, and when it takes a hit, so does CoQ10 (a vital energy booster for your body) and vitamin K2, causing common side-effects such as muscle pain and weakness
According to research in March 2022Ā¹āµ, muscle pain is strongly linked to statin use, with 73.5% of individuals experiencing this discomfort, often leading them to consider discontinuing their medication.
*SAMs stands for Statin-Associated Muscle Symptoms
Statin Usage in the United States
Research About GG
Recent studies, such as the one published in the Journal of Clinical Lipidology in 20237, have indicated that GG supplementation can alleviate muscle pain and enhance muscle strength in individuals undergoing statin therapy. Patients who incorporated GG into their regimen reported feeling better and expressed higher satisfaction with their treatment compared to those who did not.
The study also indicated that CoQ10 is, at best, a partial statin solution, whereas GG may be a better solution to address SAMs (statin-associated muscle symptoms)16. Hence CoQ10 and GG combination may be used as a āstatin companionā to satisfy the unmet need generated by statinās usage7 .
Who Should Take GG?
View Full Study
Overall, anyone who wants to support the health of the heart, bones, and muscles could benefit from GG by replenishing the loss of GG due to aging or medications.
If you are already on statins and having side effects, such as muscle discomfort, GG supplementation is highly recommended. It has the potential to complement statin therapy for individuals experiencing SAMs, such as muscle pain and weakness.
A FRIENDLY REMINDER:
Before starting any supplement regimen, it is advisable to consult with your doctor, especially if you have a diagnosed heart condition or are taking any medications.
ā¢ Manage arterial calcification
ā¢ Support healthy blood pressure and circulation
ā¢ Manage cholesterol and inflammation
ā¢ Heart and artery support from a cellular level
ā¢ Manage arterial calcification
ā¢ Healthy cholesterol balance
ā¢ Support muscle health and cellular function
ā¢ Support CoQ10 production and cholesterol synthesis
ā¢ Recommended for statin users
ā¢ Superior fish oil with 700 mg of DHA per serving
ā¢ Premium ubiquinol CoQ10
ā¢ Support heart and brain health
ā¢ Highly bioavailable form of magnesium.
ā¢ Support cardiovascular and muscle health
ā¢ Promote sleep and brain function
Xtendlife's Science-Based Supplements for Heart Health
Statin Side Effect Support
GG Pure is a natural source of Geranylgeraniol (GG), specially formulated to support those taking statins. It helps maintain healthy CoQ10 levels and supports cholesterol synthesis, promoting muscle comfort and healthy aging.
LEARN MORE
CoQ10 Synthesis and Energy Production
GG is the building block of CoQ10, responsible for energy production in muscles, particularly the heart. GG supplementation may support the natural production of CoQ10.
Support Muscle Comfort
Age-related muscle pain & deterioration are often related to aging, but can be made worse by taking statin medication. Research suggests that GG supplementation can maintain normal muscle health and function.
Support for Bones
GG Pure supports the normal uptake of calcium into bones and teeth while inhibiting calcification of soft tissues such as blood vessels.
Natural, Science-Backed Formulation
GG Pure is formulated with the trademarked ingredient GG-GoldĀ®, which has been featured in numerous independent studies over the decades for its efficacy and safety.
Advanced Ubiquinol for Heart Health
Xtend-Quinol fuels the body with ubiquinol, the active form of CoQ10 to revitalise cells and restore natural energy levels, supports heart health and healthy aging.
LEARN MORE
High Dose of CoQ10
CoQ10 helps generate energy for cells, particularly the heart. Xtend-Quinol provides the body with a direct source of CoQ10 as ubiquinol, the bioactive form the body prefers.
Bioavailable Formulation
Xtend-Quinol is formulated using a unique absorption technology. It includes GG acting as a natural stabilizer to increase the bioavailability of ubiquinol CoQ10 for better absorption.
Healthy Aging Benefits
Your CoQ10 levels decline with age and medications such as statins, which may lead to health issues like muscle weakness, and loss of energy. Xtend-Quinol may help mitigate these health issues.
Natural, Science-Backed Ingredients
Xtend-Quinol is formulated with the trademarked ingredients DuoQuinolĀ®, and GG-GoldĀ®, which has been featured in numerous independent studies over the decades for its efficacy and safety.
"I believe heart disease is preventable, we know the factors. Heart disease is reversible, we know how to do it - even if youāve already suffered a heart attack.
How? Through lifestyle change and great supplements. Thatās why Iām so glad I found Xtendlifeās range of heart support supplements. Theyāve literally blown me away.ā
Dr. Joel Kahn, MD, FACC, "America's Healthy Heart Doctor"
About Xtendlife: Who We Are
Xtendlife is a natural supplement company located in the beautiful land of New Zealand. Founded over 25 years ago, the company strives to provide dietary supplements containing only the best possible ingredients.
The Xtendlife supplements and quality meet the approval of āAmericaās Healthy Heart Doctorā - leading cardiologist, Dr. Joel Kahn17
Evidence-Based Nutrition for Your Heart
In 2022, Xtendlife was nominated as one of the 10 Best Companies in Nutraceutical Market, November 2022.
Xtendlife is on a mission to provide people with the foundation for better health that enhances their quality of life - using the power of science and nature alongside our core values: Integrity, Purity, Innovation
Natural Products Made in New Zealand
1 STOFFEL, W. et al. Synthese der K Vitamine and Ubichionone. Agnew Chem. 1960;72(17);627-627
2 https://r-statistics.co/Complete-Ggplot2-Tutorial-Part1-With-R-Code.html
3 https://www.wholefoodsmagazine.com/articles/3268-a-new-supplement-brings-many-health-benefits-gg
4 https://www.xtend-life.com/blogs/supplement-ingredients/geranylgeraniol
5 https://www.mayoclinic.org/drugs-supplements-coenzyme-q10/art-20362602
6 https://pubmed.ncbi.nlm.nih.gov/34785587/
7 https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1246589/full
8 https://www.casi.org/node/1060
9 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315720/ 10 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646228/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646229/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646230/
https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.120.046542
https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1246589/full
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034880/#
CAMPIA, I. et al. Geranylgeraniol prevents the cytotoxic effects of mevastatin in THP-1cells, without decreasing the beneficial effects on cholesterol synthesis. British Journal of Pharmacology. Dec 2009;158(7);1777-1786.
17 https://insightscare.com/xtend-life-natural-products-a-natural-scientific-way-to-xtend-quality-healthy-living/