Zonmw JPI HDHL

19-06-2015

A healthy diet for a healthy life | 19 june 2015

JPI A Healthy Diet for a Healthy Life – 3rd International Conference

Table of contents 3rd international conference JPI HDHL 4

Introduction

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Opening

DR. MARTIJNTJE BAKKER Vice chair JPI HDHL

DR. JOHN BELL Director of Directorate F - Bioeconomy, DG Research & Innovation, European Commission.

10 Uniqueness of JPI HDHL DR. PAMELA BYRNE Chair of JPI HDHL

14 WHO Food and Nutritional Policies and Strategies in Europe and outcomes of the 2nd International Nutrition Conference DR. JOAO BREDA WHO Europe, Program Manager, Nutrition, Physical Activity and Obesity

22 Thoughts 26 Running Point Actions of JPI HDHL

- DEDIPAC BY DR. JEROEN LAKERVELD EMGO Institute for Health and Care Research VU University Medical Center

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- ENPADASI BY DR. JILDAU BOUWMAN TNO Quality of Life - FOODBALL BY PROF. DR. EDITH FESKENS Human Nutrition WUR

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EUROPEAN COLLABORATION Nutrition Security DEBATE WITH INDUSTRY How research and industry in the field of JPI HDHL can work together RESEARCH INFRASTRUCTURES Data sharing & standardisation DEDIPAC First accomplishments across three thematic area

56 The future of our science

CHALLENGES, CHANCES AND MY PERSONAL VIEW, VALEDICTORY PROF. DR. HANNELORE DANIEL Chair SAB

64 Closing Comments DR. PAMELA BYRNE Chair of JPI HDHL

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Introduction Dr. Martijntje Bakker Vice chair JPI HDHL

It is a meeting of cultures as well as a meeting of methods and minds. In the rich set of presentations of today we will see examples of what can be achieved when we can be open and invite each other to truly participate and share our experiences and knowledge If you want to join us and want broader and quicker results with your own research programmes, team up with us, and the 25 countries that are already actively participating.

If you have something to give or to gain from this program than please join forces.

“We have a very interesting program for the day. I look forward to our speakers and their messages.”

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The important thing for me is that we have made strong progress in the process of collaboration. This program requires the building of relationships and developing trust and we have seen a great acceleration of the projects in the last months.

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Opening by Dr. John Bell Director of Directorate F Bioeconomy, DG Research & Innovation, European Commission.

The challenge of alignment demands a life long effort. We are at the moment of truth for what it is that our mission should be. If we want to face the critical challenges we will need to continue our focus on working together in different, more cooperative and open ways. We are partners in these challenges to mobilize all the required efforts.

There is a real stirring need for a new agenda to actually make a change. We cannot face the challenges with the old assumptions. Regarding health: we’re moving into what could be seen as a perfect storm. In this storm there is a double burden of nutrition and health & wellbeing.

What should our agenda be as researchers? How can we mobilise the political forces so we can operate effectively? This requires conversation and agreement on what we think what needs to happen. It needs to be sufficiently ambitious and very effective if it is to address the challenges of our time. Research has really been a

game-changer for the European Union.

This has had a life long impact. We try to build an environment so it is easier to operate as research institutions, so we can innovate and further a knowledge based approach. Hoping for and simply wanting change is not enough. We are almost at a point of no return. Formulating a clear agenda will also require a paradigm shift. What do we want to actually achieve with our research and programs.

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Dr. John Bell: “Give us your feedback and what we can do to help you take a step forward.�

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Dr. John Bell: “If we want to face the critical challenges we will need to continue our focus on working together in different, more cooperative and open ways.�

With Horizon 2020 we have a strong and ambitious Framework in place that can give us the tools we need as researchers to achieve change. It is a flexible program that provides us with resources to do our work.

The internationalisation of the work we do is extremely important. What global researches are doing in this area is very impressive. The facilitator role researchers and the JPI play, is incredibly valuable and important. We need this as a way to receive the feedback from the field on what needs to be done. Taking research into the innovation and implementation space is a critical and vital next step.

This is a difficult challenge that needs to be discussed and addressed in the coming months and years. As a community we need to listen and learn. The research community needs to speak and be heard.

A lot can be done, and there are many parties that are willing to take action, if the agenda is sufficiently clear. We want

to give you the support that you need to do your work. Give us your feedback and what we can do to help you take a step forward.

“Regarding health: we’re moving into what could be seen as a perfect storm.�

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Researchers are pioneers and innovators. As forward-thinking people we understand what needs to be done. It is our task to demonstrate what it is that needs to be done and how this can be done, to achieve a breakthrough. I firmly believe we need to step out of our comfort-zones and go beyond what we already know. What research achieves when we succeed in challenging ourselves impresses me every day.

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Dr. Pamela Byrne: “Tell us what you’re doing. Tell us what you need.”

Uniqueness of JPI HDHL Dr. Pamela Byrne, chair of JPI HDHL

The societal challenges of increasing diet related disease is not a local issue.

This is a global issue. If we don’t engage with the end-users, from the onset, our research will be only research and output. Output of research needs the end-user to achieve an actual outcome in the world. The same holds true for our strategic research agenda. If this gathers dust it is of no use. We need to identify how we will implement our research agenda, what steps we will need to take to achieving our objectives and ambitions.

The Joint Actions we have taken have not been an easy task. It has stretched

the resources of the member countries of the JPI HDHL and it requires a huge amount of effort. Bringing the right people together to achieve the impact that we desire demands a strong initiative, commitment and dedication. The JPI is not only about Joint Actions, joint initiatives and funding. It is also about maximizing the investment and maximizing impact through alignment. So we need you to tell us what you’re doing. Tell us what you need.

One joint activity which the JPI HDHL and FACCE have been collaborating on is a joint paper on research needs in the area of food security and nutrition security. This paper will serve as an input to the EC Online Consultation on the Role of Research in Global Food and Nutrition Security.. We hope our inputs will be taken up into a single roadmap for the different fields that have a strong relation.

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The past 5 years have been on an impressive journey. We now have over 25 partners including international partners New Zealand and Canada. It is through an open dialogue with all partners and related initiatives that we have begun to create meaningful change. The JPI HDHL is open to new partners, we are constantly seeking new partners and we continue to constantly engage when we see new opportunities. We invite everybody and anybody, from any country or institution to contact us to work together.

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We need to constantly stop and re-asses and adjust when this is necessary to stay relevant. Look back and look around us to ensure what we are doing still makes sense.

The JPI HDHL will be developing their second implementation plan over the next few months and this plan will cover the period 2016 - 2018. A longer timeframe regarding funding will give a more structural backdrop for our roadmap. We need to recognize that what we have done in the past years is an important strategic investment. We now need to build upon the strategic investment that has been made to date.

There is a need for us to be able to capture important data, critically analyse that data so that it can inform the future direction of research. When we critically analyse the data we can adjust the research to improve the quality and to move it towards implementation.

It is important to collaborate from the outset. It is important that we all consider the issue collectively, bringing together all our expertise and skillsets.

When we have identified the possible solution, each partner can then work individually on the components of that solution. We can then bring together all of the outputs to achieve the desired impact.

“With more open access we will be able to move further, much faster.�

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Dr. João Breda: “We really need the data.

We really need guidance and leadership. We need to move from rhetoric to practice. We need to move from thinking to doing.”

by dr. JoĂŁo Breda, WHO Europe, Program Manager, Nutrition, Physical Activity and Obesity

Congratulations are in order. We are reaching a new era in international collaboration. But business as usual will definitely not bring the solution. Body weight and diet are emerging as the most important risk factors for disease and disability. Noncummunicable diseases (NCDs) currently cause more deaths than all other causes together.

The second international conference on Nutrition (ICN2, November 2014) organised in Rome by FAO/WHO welcomed over 2200 participants – which represented more than 170 governments and

many stakeholder organisation, opinion leaders, researchers and development experts. The commitments from the Rome Declaration on Nutrition include preventing all forms of malnutrition, to enhance sustainable food systems promoting healthy diets throughout the life course. It also elaborates on the need to create enabling environments for citizens to make informed choices and the need to strengthen and facilitate contributions and actions by all stakeholders. The commitments will be implemented through the voluntary ICN2 framework of action existing out

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WHO Food and Nutritional Policies and Strategies in Europe and outcomes of the 2nd International Nutrition Conference

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of a set of policy options and strategies which governments may incorporate into their national development and investment plans, and consider in negotiating international agreements to achieve better nutrition for all.

We now have more and more data we can actually compare, across countries because of the synchronisation of how we do research and analyse the date.

One of the most challenging points is that we see a huge inequality regarding diseases across countries. The term health is often far too marginally addressed in international discussions about food and food-security.

WHO provides upstream policy advice to set national targets. 6 global targets for nutrition to be attained by 2025 have been set. If we want to achieve these targets We really need the data. We really need guidance and leadership.

We need to move from rhetoric to practice. We need to move from thinking to doing.�

“One of the most challenging points is that we see a huge inequality regarding diseases across countries.”

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Dr. João Breda: “Body weight and diet are emerging as the most important risk factors for disease and disability.”

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Thoughts?

Bram Moeskops: TP Organics (ETP)

My hope for the JPI program and today is that it brings more attention to how the specific qualities of organic foods can contribute to healthier lifestyles.

Peter Clarys:

Vrije Universiteit Brussel Belgium

Compiling and connecting all the available data across research and across countries is necessary to come to compelling and powerful evidence. We can use this evidence to base our policies upon and to distill accurate knowledge regarding health and nutrition.

Actively stimulating and facilitating contact by the JPI is a very important element for me.

Nikola Schulz:

Forschungszentrum Jülich

James Conway:

Member of the Management Board of JPI HDHL (Ireland) I hope we can go home and stimulate greater national support for these European initiatives. This is not a transient issue or one-time event, it deserves and requires a solid follow through. We really need a clear idea regarding how we should progress and how we can differentiate this program form other programs.

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It’s important to establish real connections on a European level.

If we want to achieve our ambitions, we need to actively make the time to regularly reflect on the actions and programs.

It requires looking beyond borders of countries as well as connecting different European programs.

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Rapheal Caplan: European Commission.

Belgium

Our common objectives are clear.

In my opinion the next step is an explicit and very clear roadmap .

From a practical point of view we need to translate our objectives into steps and actions to take, going forward. If we can formulate that next step, we can move forward.

Liis Kambek:

Ann Joeleht:

National Institute for Health Developers Estonia

National Institute for Health Developers Estonia

I believe strongly in the paneuropean cooperation in Nutrition security and our ability to assure a safe supply of nutritious food for the future generations. We should stop wasting resources and we should stop wasting food. Collaborate!

The joining of the common interest and efforts is the key takeaway for me today. It’s a gradual process and the information on how to engage with industries is valuable and helpful for me.

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Running Joint Actions of JPI HDHL DEDIPAC by dr. Jeroen Lakerveld, (EMGO Institute for Health and Care Research VU University Medical Center) DEDIPAC (Determinants of Diet and Physical Activity) is a Knowledge Hub to integrate and develop infrastructure for research across Europe. DEDIPAC aims to understand the determinants, at both the individual and group levels, regarding dietary, physical activity and sedentary behaviours using a broad multidisciplinary approach, and to translate this knowledge into a more effective promotion of a healthy diet and physical activity.

“Coordination of an overall research effort is challenging and it has complex issues.”

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Dr. Jeroen Lakerveld: “Our overall aim is to develop a Knowledge Hub. Europe provides a very valuable environment for research, due to the different cultural, behavioral en economic variance.”

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Dr. Jeroen Lakerveld: “The collaborations and consortiums that are in place prove we are slowly but surely succeeding in our aims.�

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Running Joint Actions of JPI HDHL ENPADASI by dr. Jildau Bouwman, (TNO Quality of Life) ENPADASI consists of a consortium of 51 research groups from 9 countries.

The main objective of the ENPADASI Knowledge Hub is to deliver an open access research infrastructure that will contain data from a wide variety of nutritional studies, ranging from mechanistic/interventions to epidemiological studies including a multitude of phenotypic outcomes that will facilitate combined analyses in the future. ENPADASI will focus on 1) database development 2) integration of existing databases 3) training of researchers to use the database.

“The resolving of data-sharing issues is extremely important in increasing the power of research.”

“Stimulating the sharing of data and studies requires that we understand the perceived advantages and disadvantages researchers have.”

“Assessing the qualities of studies is a very important element when we want to combine and integrate data.”

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Dr. Jildau Bouwman: “The mechanisms behind diseases are very complex. This requires high-power research.”

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Dr. Jildau Bouwman: “Sharing and aligning study-designs helps in data sharing and it helps to increase the quality and reach of research.�

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prof. dr. Edith Feskens: “Dietary assessment is extremely population specific and prone to error and especially when it involves selfreporting, it can easily become unreliable.�

Running Joint Actions of JPI HDHL FOODBALL by prof. dr. Edith Feskens, (Human Nutrition WUR)

Data-mining from food purchasing and other data-analysis approaches can be used additionally to bio-markers or it might be included in validation studies in the future.

Every step we add to the dietary assessment approach involves new steps and new information to consider, with which it becomes more and more complex. In a way it feels like searching for a Holy Grail, which we know we might never find.

“The current state of dietary assessment is stuck in the past.”

“There is urgency to the work we are doing, because it acutely shows we really need better tools.”

“The biomarker approach offers an opportunity for innovation. It requires a different and analytical approach that can partly resolve concerns.”

“Food-metabolomics is a promising field. With this combined approach we aim to build upon the methods so we can improve, add to and modernise the dietary assessment.”

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The project aim at the validation of biomarkers and the investigation of intake/exposure and nutritional status of biomarkers in the area of nutrition and health.

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Prof. Dr. Martin Scholten: “Is eating less meat more sustainable? ” Dr. João Breda: “70-80% Of what we eat should be fruits and vegetables.”

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Workshop 1: European Collaboration: Nutrition Security Chair: Dr. Pamela Byrne Dr. Micheal Grusak (USDA-ARS), prof. dr. Martin Scholten (Wageningen University), prof. dr. Lynn Frewer (Centre for Rural Economy School of Agriculture, Food and Rural Development) and dr. Joao Breda (WHO)

Lynn Frewer opened the floor with introducing nutrition security as a wicked problem – though we need a solution and the multiple drivers of food insecurity need to be dealt with simultaneously. Truly transdisciplinary research combining natural and social sciences,

food safety and nutrition and availablilty is needed. Innovation should combine societal priorities and requirements with technological possibilities. Integrated dataset are needed to escape from disciplinary silos.

Michael Grusak spoke about the nutritional impacts of climate change on major food and forage crops. “We need more information and a better understanding on nutritional impacts of climate change on major food and forage crops to facilitate breeding efforts to counteract nutrient declines. We need more detailed information on regional consumption patterns and health status to model/predict where nutritional problems will occur and which foods to target for health improvement. Furtermore coordination across the whole food change is essential and therefore we need interdisciplinary teams linking research in nutrition, agriculture, food industry, environment, policy etc.”.

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One of the greatest challenges of the 21st century is on providing nutrition security while dealing with climate change. Often the focus of the debate and research is limited to food security – however access to food and the consumption of safe and nutritious food are important aspects of this challenge.

This workshop was a follow up of the joint FACCE-JPI – JPI HDHL event in the EC pavilion at the EXPO in Milan, and built on the output of the Grand Debate to provide further input into the common paper that the two JPIs will deliver on Nutrition Security. The paper will feed into the strategy and activities of the JPIs and will be hand over to the EC in September 2015.

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While Martin Scholten raised the question: Is eating less meat more sustainable?

“In an ecosystem, biomass is being used efficiently; we should be nature inspired and make more proteins out of grass.” Martin Scholten argues that from an ecological perspective the environmental arguments to exclude nutritious animal products from a diet are not valid. When approaching food production in a more holistic way – livestock can play a key role e.g. to maintain the quality of the soil and to convert raw biomass into nutritious food.

This does require a change in approach – e.g. regarding what to feed the animal and to have a public health approach for livestock as a healthy animal is a more environmental friendly animal. Cooperation between FACCE JPI and JPI HDHL is promising to enable a Climate Smart and Sustainable Nutrition Security approach.

Joao Breda brings in the public health perspective of nutrition security. He argues the importance to strengthen the governance, alliances and networks to ensure a health-in-all-policies approach.

Sustainability and food security involve balance. We need to think about healthy diets – but how do we define a healthy diet? Food security is more complex tahn just providng food for everyone.

Most of the Europeans that suffer from

obesity are food-insecure. We need to provide more food but also better food by more balanced diets. We need to reinforce health systems to promote healthy diets and create an environment that supports a healthy diet.

“We need more information on nutritional impacts of Climate Change on major food and forage crops.”

“We need to think about healthy diets – but how do we define a healthy diet?”

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Prof. Dr. Lynn Frewer “Innovation should combine societal priorities and requirements with technological possibilities.�

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Workshop 2: Debate with industry: how research and industry in the field of JPI HDHL can work together Chair: Dr. Duane Mellor (EFAD) Dr Grigoris Risvas (European Federation of Associations of Dieticians); dr. Chris Birt (European Public Health Association) and dr.

Rolf Bos (Top institute Food and Nutrition, TIFN)

Dr. Duane Mellor set out the ground rules and aimed to drive towards recommendations for research collaborations/funding that are transparent and supporting ‘Healthier Diets for Healthier Lives’.

Dr. Chris Birt is convinced that industry should never be involved in public health research because profit is their ‘core business’.

Dr. Grigoris talked about encouraging collaboration in the interest of scientific discovery and public health. Public Private Partnership is needed to support change. But said there should be two

main rules/principals: 1.There must be a benefit for the public.

2. The researchers are in control of the idea, design and reserach must be controlled by scientists and published without restrictions.

Rolf Bos said that if we want to compete with the US and China we need to integrate Research and Development to: - Increase our export position - Get a higher added value - Turn knowledge into value Every company has a social responsibility, it is more than only making money.

Colleboration is based on trust: understanding, transparant & constructive colleboration is required.

The JPI HDHL should look into ‘best practices’ on colleboration between research and industry and develop a framework for this type of colleboration.

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Leading on innovation in nutrition and health research or spinning their web of influence? This workshop explored transparent collaboration between the food industry and research organisations through a debate of speakers pro-, against and working with the industry.

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Dr. Chris Birt: “Food systems are constructed not to deliver optimal human health but to maximise profits.”

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Dr. Grigoris Risvas: “ Public Private Partnership is needed to support change.”

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Workshop 3: Research Infrastructures (RI): data sharing & standardisation

The main aim of this workshop was to explore and advance the synergy between research and infrastructures by discussing the common interests.

Thereby applicants took into account the: - Scientific need: What do you need as a scientist form the RI and what could you contribute?

- Governance: What governance issues need to be settled, what are your needs and experiences?

-Technology: How have you solved your technical data/tool challenges, how can colleagues benefit?

- Experience from existing / emerging RIs: The DISH-RI is in its infancy. What is the way forward.

The workshop started with a short introduction of the chair prof. dr. Pieter van ’t Veer. He gave a presentation regarding EURODISH. EURODISH is studying the need for food and health research infrastructures in Europe. The EURODISH consortium has formulated

a conceptual design for an overarching Research Infrastructure (RI) so-called ‘DISH-RI’. DISH-RI is a RI that is specific for studying food in relation to nutrition and health and connects the currently fragmented pieces of research on determinants, intake, status and health (DISH). DISH-RI enables researchers in Europe (and beyond) to efficiently conduct EU-wide food, nutrition and health research.

“Well-described ontology’s together with the highresolution data can provide unique services to stakeholders and

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Chair: prof. dr. Pieter van ’t Veer (EURODISH) prof. dr. Lars Ove Dragsted (FOODBAL), dr. Jildau Bouwman (ENPADASI), Nadia Slimani (IARC), Anne Loyen MsC (DEDIPAC) and Andrew Smith (ELIXIR)

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citizens.”

DISH-RI will facilitate interdisciplinary research, will allow to facilitate unlocking currently inaccessible data and will stimulate development of interoperable tools and services to the research community. This way, DISH-RI will enable cutting- edge research that serves to advance the knowledge needs formulated in H2020, JPI-HDHL, and by food industries as public and private stakeholders. Subsequently the Joint Actions ENPADASI, DEDIPAC and FOODBALL shared their experience regarding data sharing and standardisation as well as ELIXIR (European infrastructure for biological information) and IARC (International Agency for Research on Cancer, WHO).

After the presentations small group discussions took place to explore and advance the synergy between research and infrastructures by discussing the common interests. Some conclusions from the workshop are: - TOOLS for assessment: Ontology’s (‘definitions and grammar’) for what we are aiming to assess are unique to the Food and Health field. And if definitions are different how are the data/measurements quantitatively and qualitatively related? Apart from being unique, this is highly relevant to reproducibility and standardisation of research in this area.

- DATA obtained in research (and to be connected): The RI could and should enable a much higher level of resolution in nutrition research, in all pillars of the DISH, i.e. time & place specific food consumption and lifestyle data, food and nutrient intake/biomarker data, X-omics on metabolism/function and eventually risk factors.

- SERVICES: For most RIs the scientific community is a key stakeholder and the RI provides further services to policy (EU, national) and in the public and private domain (competitiveness).

On top of this generic RI-characteristic, DISH-RI also addresses the EU-citizens themselves, i.e. they are both provider and user of data.

- Privacy/ethics and legal issues differ depending on the type of data. RIs and JPI HDHL should join forces to resolve data privacy issues.

- Work done in one project or RI should not be duplicated, therefore it should be clear who does what (funders can help with organizing meetings).

- Maintenance and access to research data (for re-analysis, secondary analyses, linkage and sharing) after ending of the project is a very important and big challenge.

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“That there isn’t a dedicated Food and Nutrition Research Infrastructure on the ESFRI roadmap is not a justification in itself that there should be. Define the user need!’’

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Workshop 5: DEDIPAC: first accomplishments across three thematic area Chair: dr. Jeroen Lakerveld (EMGO Institute for Health and Care Research VU University Medical Center) Dr. Janas Harrington (University College Cork), prof. dr. Nanna Lien (University of Oslo) and dr. Marieke de Craemer (Ghent University).

DEDIPAC KH is the first pilot action to contribute to the Determinants of Diet and Physical Activity pillar of the Strategic Research Agenda (SRA) of the JPI HDHL, started at the end of 2013. Within DEDIPAC, a European trans-disciplinary research network of selected research groups (42) and scientists (300) from 12 JPI countries, (“knowledge hub�) carry out joint trans- and multidisciplinary activities to integrate biological, behavioural and social sciences expertise. The aim is to contribute to a better understanding of how biological, ecological, psychological, sociological, economic and socio-economic factors influence consumer decision- making and how to translate that knowledge into the development of strategies for effective disease prevention in target populations.

After the presentation the discussion with the participants started. The huge amount of work that has been done, but also the complexity of the field was

what interested the participants. The main question: how to sustain what has been, and will be, achieved by the network after the end of DEDIPAC? Some conclusions were: here is very little ongoing international surveillance of behaviour though there is need for such surveillance based on harmonised and validated methods and the toolbox that DEDIPAC will provide can contribute to this need.

Furthermore more attention in research and policy is needed for contextual determinants (environment, cultural background etc and leadership methods should be further explored to make the best use of multidisciplinary approaches.

- more attention to contextual determinats (environment, cultural background etc.)

- need for leadership methods to make best use of multidisciplinary approaches

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The workshop started with short quiz.

Three presentations elborating on the first accomplishments and expected outcomes of the three thematic areas of DEDIPAC followed: Area 1: Assessment and harmonisation of methods for future research, surveillance and monitoring, and evaluation of interventions and policies.

(Dr. Janas Harrington) Area 2: Determinants of dietary behaviour, physical activity and sedentary behaviour across the life course and in vulnerable groups.

(Prof. dr. Nanna Lien) Area 3: Evaluation and benchmarking of public health and policy interventions aimed at improving dietary behaviour, physical activity and sedentary behaviour across the life course. This workshop will elaborate on the first accomplishments of DEDIPAC and the expected outcomes.

(Dr. Marieke de Craemer)

“The Knowlegde Hub is looking for options to sustain and continue the work.�

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Question from the audience “How are stakeholders involved in development in the policy toolbox?�

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Full members

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Observers

Austria Belgium Canada Cyprus Czech Republic Denmark Estonia Finland France Germany Ireland Italy Latvia New Zealand Norway Romania Poland Slovakia Slovenia Spain Sweden Switzerland The Netherlands Turkey United Kingdom

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The future of our science: challenges, chances and my personal view.

Putting up a crystal ball and looking into the future, I dare to say the future of scientists in Europe is in danger. I’m lucky, as a German scientist I don’t need the money from Brussels. But many others from other countries do need the money desperately to fund their research. I hope the commission rethinks how things are done since funding rates in the Horizon 2020 program are extremely far too low.

reported the overall lack of reproducibility of findings in the life and social sciences with between 50% and 85% of all reported studies classified as not reproducible. We thus need a largescale Reproducibility Initiative and that also in the food-diet-health relationship.

Replicability needs to get a lot more attention and critical independent verification is of highest importance if we want our work to mean anything.

The output numbers of scientific articles from Europe has increased steadily and shows currently higher growth rates than those of the US. Scientific knowledge doubles every nine years.

But we don’t see any of this return in the investment of structural quality of research and funding. It looks like quantity is far more important than quality.

That to me seems the wrong way to go.

That sciences goes wrong is now also in public debate. A series of papers

Since we also build careers on citation and h-indices for these not-reproducible studies, the science systems based on numerical measures seems to fail crossly. We thus need urgently need a new Assessment of Science Initiative that takes other measures for example societal impact and trust based on peer judgement into account.

Many problems in current science arise from entropy. Science has reached a

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Valedictory prof. dr. Hannelore Daniel (Chair SAB)

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Dr. Pamela Byrne: “You have presented us with important challenges to consider and it has been a privilege to be able to work with you.�

Other problems in current science arise from an insufficient level of standardisation and the lack of incentives for standardisation efforts. And this applies for some fundamental routines and measurements such as for example oral glucose tolerance tests in experimental animals and humans. We thus need a Standardisation Initiative.

Standardised approaches should be developed via ISO (international organisation for standardisation). Funding organisation should make funding dependent on standardized methods and procedures and enforce thereby a better quality and reproducibility of the research done.

Science communication, framing and food messaging are also import topics to address. Trust in science – in particular in the food, diet and health area – is declining and that requires as well measures for improvement. We thus need the Science Communication Initiative with quality assurance. “If we rate hotel and put five stars on a resort, why can we not put 5 stars on something communicated to the public as a scientific community.”

It is my dream that Europe is a place where all these things are improved. In my heart I desire that we as scientists and the people of Europe start this process to become the centre of excellence in trust and quality of science.

Make Europe a better place for better science.

“We see complete ignorance of previous findings and decades of safety assessment” in some studies making major claims on diet effects on human health.“

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very high level of granularity and a lack of perception of importance of details.

We create very artificial experimental realities as best practise but then we draw conclusions for real life. We see complete ignorance in high level studies on previous knowledge and scientific claims in particular on human health based on some rodent studies that bare proper dose-response relationships.

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Closing comments Dr. Pamela Byrne, chair of JPI HDHL The JPI HDHL has achieved a lot over the last 2 years. We invested over E51m in strategic research areas; we have identified and are working with other initiatives to find impactful solutions to address this global challenge; we have used innovative tools to explore the complexity of this area; we have developed strategic partnerships across the globe.

But there is much more to do. In the coming years we will continue to mobilise the appropriate resources, invest strategically, build new and strengthen existing partnerships to develop practical, innovative and sustainable solutions that will enable consumers in Europe and beyond to live a healthy life.

Through working in collaboration with our partners across the world, we will all be in a position to make a real difference in people’s lives. We are really interested in your input to our future please send us your thoughts and your ideas to ensure that we can achieve our goals.

Dr. Pamela Byrne: “Please send us your thoughts and your ideas to ensure that we can achieve our goals.�

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Colofon 3rd international conference JPI HDHL JPI HDHL thanks everybody who contributed to this magazine and the third international conference of JPI HDHL. The HDHL CSA has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement n.

277673.

JPI HDHL project manager & CSA coordinator Jolien Wenink (jpihdhl@zonmw.nl)

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Contact Us

MB Chair: Pamela Byrne: chair@healthydietforhealthylife.eu JPI HDHL project manager and CSA coordinator: Jolien Wenink (jpihdhl@zonmw.nl) www.healthydietforhealthylife.eu

Visuele Notulen www.visuelenotulen.nl info@visuelenotulen.nl Art direction Diederik Vrijhoef Magazine Design Charlotte Porskamp Fotografie Jet van Gaal Copywriter Wim Kuper Editor Anouk Verbruggen

Production

www.decongresbalie.nl info@decongresbalie.nl

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Thanks to

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