Holistic Health Telomere Study

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Life Length biotechnology laboratories Study on the Holistic Complex

Results February 2022


THE CLP HOLISTIC COMPLEX HAS A PROVEN PROTECTIVE ROLE ON TELOMERE SHORTENING AND HEALTHY AGING CLINIQUE LA PRAIRIE PRODUCTS ARE ABOUT THOROUGHLY SCIENCE-BACKED SOLUTIONS. A LIFESCIENCE STUDY ABOUT THE CLP HOLISTIC COMPLEX (THAT IS AT THE CORE OF EACH HOLISTIC HEALTH SUPPLEMENT) SHOWS THAT IT HAS BENEFICIAL EFFECTS BY DECREASING THE RATE OF TELOMERE SHORTENING AND PRESERVING TELOMERE LENGTH UNDER NORMAL CONDITIONS, THUS CONTRIBUTING TO LONGEVITY.

WHAT IS A TELOMERE? Our genes are organized inside the cell nucleus as DNA molecules called chromosomes. Telomeres are short repetitive sequences of DNA at the end of each human chromosome, forming a protective cap. Telomeres play vital roles in multiple cellular processes because they protect chromosomes from end-toend fusions and chromosomal instability.


WHAT HAPPENS AS WE AGE? As cell division occurs, telomeres become successively shorter until chromosomes reach a critical length and can no longer replicate, which means that cells can no longer divide and they become senescent or die. Lack of cell repair and accumulation of senescent cells can deteriorate an organ or tissue.

"SINCE SHORTER TELOMERES HAVE BEEN IMPLICATED IN DNA INSTABILITY, CHRONIC DISEASES, AND ONCOGENESIS, THE RATE OF TELOMERE SHORTENING IS CRITICAL TO IMPROVING HEALTH AND SLOWING AGING."

TELOMERE LENGTH HAS BEEN RECOGNIZED AS ONE OF THE BEST BIOMARKERS OF AGING Considerable efforts have been made over the past few decades to develop measures of aging impact which are reliable, precise, and robust. An accelerated telomere attrition rate is also a common feature of age-related diseases. Evidence shows that reduction in telomere length is associated with failure of cell division and senescence of normal cells and that oxidative stress and inflammation can contribute to a greater shortening of telomeres. Oxidative stress is a condition that occurs when there is an excess of free radicals produced during metabolic processes in the body’s cells. The imbalance between free radicals and antioxidants plays a significant role in aging, causing changes in proteins, lipids, and DNA.


One major consequence of oxidative stress is DNA damage, which includes telomere shortening and modification of the structure of DNA, altering its coding properties, and interfering with cell processes. Oxidative stress can be triggered by factors such as diet, lifestyle, pollution, and radiation, as well as by the body’s natural immune response, causing inflammation that disappears after the immune system repairs an injury or fights off infection. Chronic inflammation associated with aging and conditions like autoimmune diseases, cancer, diabetes, hepatitis, inflammatory bowel disease, and others, or long-term exposure to irritants such as industrial chemicals or polluted air, can accelerate telomere loss and cause cellular senescence. Over time, chronic inflammation can trigger the immune system to attack healthy tissue and organs and increase your risk of age-related conditions.


ABOUT THE IN-VITRO EXPANSION STUDY CONDUCTED BY LIFE LENGTH LABORATORIES TO INVESTIGATE THE PROTECTIVE EFFECT OF THE CLP HOLISTIC COMPLEX ON TELOMERES Study design: Telomere-length measurement using telomere analysis technology The CLP Holistic Complex was tested on human cells (primary fibroblasts) to investigate its effect on telomere length. In this eight-week-long expansion study, the laboratory analyzed how different doses of the complex simulate the aging process that cells undergo for more extended periods. Telomere length was measured using Life Length’s proprietary CLIA (#99D2112462), and ISO 15189 accredited Telomere Analysis Technology (TAT®).

Study Results: THE TELOMERE STUDY SHOWED THAT THE TELOMERE SHORTENING ASSOCIATED WITH CELL AGING WAS MUCH SLOWER WITH THE CLP HOLISTIC COMPLEX SUPPLEMENTATION WHEN COMPARED TO THE UNTREATED (CONTROL) GROUP.


CELL PROFILE AFTER 8 WEEKS OF TREATMENT WITH HOLISTIC COMPLEX

PERCENTAGES OF CELLS (%)

16

Treatment with HH resulted in more cells with longer telomeres Treatment with HH resulted in less cells with shorter telomeres Control - Week 8 HH_1.56 - Week 8

10000

18000

TELOMERE LENGTH (BP)

After eight weeks of expansion, the intake of Holistic Health supplements resulted in fewer cells with short telomeres and more cells with long telomeres.

Conclusion: The study demonstrated that the CLP Holistic Complex featured in all Holistic Health supplements has a protective effect on telomeres, decreasing telomere-shortening rate, which results in cells reaching senescence later and thus delaying the aging process.

THE DATA SUPPORT A POTENTIAL ROLE FOR THE HOLISTIC HEALTH SUPPLEMENTS AS PART OF A HEALTHY DIET IN MITIGATING THE NEGATIVE EFFECTS OF AGING MECHANISMS, CONTRIBUTING TO LONGEVITY.


ABOUT THE HOLISTIC COMPLEX


AN UNPARALLELED CORE COMPLEX THAT TARGETS THE FIVE PILLARS OF HOLISTIC WELLNESS. DEEPLY AT A CELLULAR LEVEL. FIVE POWERFUL BIOACTIVES ONE HOLISTIC COMPLEX I - SYNERITHIN > Immune-protection, anti-inflammatory responses, environmental shield. II - NEUROMICS > Stress reactivity, mood balance, cognitive performance. III - NIEHANYL > Rejuvenation, stress-relief, multi-purpose body balance, longevity. IV - IMMUCELL > Natural immune system, gut balance. V - FIXENTIN > Reduction of inflammation, contribution to cellular health, healthy aging.


SYNERITHIN Antixodiant & antiinflammation

FIXENTIN

NEUROMICS

Senolytic Action

Neuro-modulation

IMMUCELL

NIEHANYL

Immunity

Rejuvenation


THE COMPLEX WORKS IN SYNERGY WITH THE BEST FOUNDATION AND ENHANCING INGREDIENTS. In each formula, our team of lifescience experts have reinforced the Holistic Complex with carefully selected micronutrients and plant extracts to elevate the overall performance.

EACH FORMULA HELPS YOU ACHIEVE YOUR GOAL DAY AFTER DAY. IMMUNITY REGENERATION ESSENTIAL NUTRIENTS AND VITAMINS SLEEP-WAKE CYCLE DETOX ENERGY AND BRAIN BOOST


ARTICLE - BIBLIOGRAPHY (1)

Aubert G, Lansdorp PM. “Telomeres and aging”. Physiol Rev. 2008 Apr;88(2):557-79.

(2) Prasad KN, Wu M, Bondy SC. “Telomere shortening during aging: Attenuation by antioxidants and anti-inflammatory agents”. Mech Ageing Dev. 2017 Jun;164:61-66. (3) Vaiserman, Alexander, and Dmytro Krasnienkov. “Telomere Length as a Marker of Biological Age: State-of-The-Art, Open Issues, and Future Perspectives.” Frontiers in Genetics, vol. 11, 21 Jan. 2021, 10.3389/fgene.2020.630186. (4)

Shammas MA. “Telomeres, lifestyle, cancer, and aging”. Curr Opin Clin Nutr Metab Care. 2011;14(1):28-34.

(5) Barnes RP, Fouquerel E, Opresko PL. “The impact of oxidative DNA damage and stress on telomere homeostasis”. Mech Ageing Dev. 2019 Jan;177:37-45. (6) Claudia P. Gonzalez-Hunt, Mandheer Wadhwa, Laurie H. Sanders, “DNA damage by oxidative stress: Measurement strategies for two genomes”. Current Opinion in Toxicology, Volume 7, 2018, Pages 87-94. (7) Coluzzi E, Leone S, Sgura A. “Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork Arrest. Cells”. 2019 Jan 3;8(1):19. (8) Kordinas V, Ioannidis A, Chatzipanagiotou S. “The Telomere/Telomerase System in Chronic Inflammatory Diseases. Cause or Effect?”. Genes (Basel). 2016 Sep 3;7(9):60. (9) Hohensinner PJ, Goronzy JJ, Weyand CM. “Telomere dysfunction, autoimmunity and aging”. Aging Dis. 2011 Dec;2(6):524-37. Epub 2011 Dec 2. (10) Jose Shyam Sushama, Bendickova Kamila, Kepak Tomas, Krenova Zdenka, Fric Jan, “Chronic Inflammation in Immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex”. Journal Frontiers in Immunology, vol 8, 2017, page 1078. (11)

John Jesitus, “Inflammation and Aging”. Dermatology Times, July 2019, vol 40, 7.

(12)

Saretzki G. Telomeres, Telomerase and Ageing. Subcell Biochem. 2018;90:221-308. doi: 10.1007/978-981-13-2835-0_9.

(13) Figueroa, Reynel and Lindenmaier, Heike and Hergenhahn, Manfred and Nielsen, Kirsten Vang and Boukamp, Petra, “Telomere Erosion Varies during in Vitro Aging of Normal Human Fibroblasts from Young and Adult Donors”. American Association for Cancer Research. 2000, vol 60, 11, 2770-2774. (14) Cherif H, Tarry JL, Ozanne SE, Hales CN. “Ageing and telomeres: a study into organ- and gender-specific telomere shortening”. Nucleic Acids Res. 2003;31(5):1576-1583. (15) Epel ES, Merkin SS, Cawthon R, et al. “The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men”. Aging (Albany NY). 2008;1(1):81-88. Published 2008 Dec 4.


C O N T A C T US HOLISTIC.HEALTH@LAPRAIRIE.CH + 4 1 21 98 9 34 81 cliniquelaprairie-hh.com

Clinique La Prairie Holistic Health | 1815 Clarens-Montreux | Switzerland


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