Science + Technology Solutions for Global Challenges

Science + Technology Solutions for Global Challenges

FUJIFILM Diosynth BioProcess Innovation Center

PARTNER. DISCOVER. TRANSFORM. We begin with partnership. Great ideas come from collaboration. Our approach crosses disciplines to inspire innovation.

Our process advances communities through discovery and design.

Science + Technology Practice

“The science of today is the technology of tomorrow.”

– Edward Teller

RTI Johnson Lab Upfit

The research and discovery taking place in laboratories both academic and commercial today has embraced a collaborative, investigative approach that drives results unimaginable in isolation. In an industry continuously redefining innovation, being a science and technology leader requires the creation of opportunities for formerly isolated fields of study to intersect, enabling new insights to be gained and fresh perspectives shared. In environments that promote interaction, our most talented scientific minds can uncover groundbreaking new solutions to the world’s biggest challenges.

Having designed more than 3.5 million square feet of complex research environments since 2010, Clark Nexsen’s collaborative process mirrors the changing landscape of R&D. Combined with a commitment to achieving our clients’ goals in design, budget, and schedule, our approach has allowed us to emerge as one of the region’s leading architecture and engineering firms in the science and technology market. We understand the trends driving facility design and the business implications of the choices our clients face.

As a trusted advisor, we work together to create spaces that promote multidisciplinary interaction and provide the flexibility to accommodate diverse, constantly shifting program requirements.

Contents

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INNOVATION & DISCOVERY The Science Behind the Building

ENVIRONMENT & AMENITIES Retaining & Attracting Top Talent

PARTNERSHIPS & DELIVERY Realizing Your Vision

ABOUT Firm Overview & Accolades

James B. Hunt Jr. Library, NCSU

01 INNOVATION & DISCOVERY The Science Behind the Building

Medicago is a company on the cutting-edge of vaccine development and production. In their Research Triangle Park facility, they are transforming access to vaccines through the production of plant-made pharmaceuticals.

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Today's research and development environments are fueled by a combination of investigative collaboration and access to cutting edge technology. Creating science and technology spaces that are flexible, state-of-the-art, and optimal has become the drive of today’s leading companies and research institutions. Life Science facilities have made a significant transition over the last 10-15 years from back of house facilities to being showcases of the great science that occurs within them. As these facilities have become more public, the desire for collaboration to occur has become a norm. Innovation in laboratory facility design has begun to include amenity spaces that foster collaboration and create a community culture inside and outside of the labs. It has become more prevalent in facilities for educational institutions, developer lead tenant laboratories, corporate research campuses, and in manufacturing facilities.

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Clark Nexsen Science + Technology / 01 Innovation & Discovery

Merging Pharma and the Greenhouse

Plant-made pharmaceuticals are anticipated to be a $100 billion industry by the year 2020. With the ability to produce 50 vaccine doses per plant, versus 1-2 doses using the traditional egg method, plant-made pharmaceuticals have tremendous capacity to protect our population from the flu, Ebola, Zika, and other diseases.

In production greenhouses like those at Medicago, plants are raised, submerged in a solution containing vaccine components, and go on to spend four weeks in an incubator, naturally replicating the vaccine to create up to 50 doses per plant and over 10 million doses per month in Medicago's North American facility.

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Clark Nexsen Science + Technology / 01 Innovation & Discovery

Flexibility For Varied Research

To meet the demands of rapidly changing research requirements, laboratory environments are increasingly called upon to be flexible and customizable.

RTI, a non-profit independent research and development company, primarily operates as a coop with researchers as tenants, making flexibility in their spaces a top priority. This laboratory renovation created spaces that support the flow of experiments for multiple groups: Analytical Chemistry (AC) group, Energy Technology Division (ETD), and Analytical Chemistry + Pharmaceuticals.

By designing new buildings and renovations that can be modified quickly and cost effectively, we support our clients in efficiently achieving their goals now and in the future.

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Clark Nexsen Science + Technology / 01 Innovation & Discovery

Interdisciplinary Collaboration

STEM, STEAM, and STEM-H demand is growing across the nation as students, private businesses, and institutions recognize the tremendous career opportunities in these fields. To create effective STEM teaching environments, designers and institutions must promote interdisciplinary collaboration, hands-on learning, and independent research.

The Health & Human Sciences Building at Western Carolina University is a cutting-edge facility that promotes collaboration between scientific disciplines as well as between faculty and students. Structured around a light-filled central atrium, labs, classrooms, a teaching clinic, and coffee shop share spaces for both collaboration and reflection. Responsive to its site, the building capitalizes on stunning mountain views with a 20,000 square foot roof garden.

LEED Gold Certified by the USGBC

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AIA Virginia Honor Award; AIA North Carolina Merit Award

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Clark Nexsen Science + Technology / 01 Innovation & Discovery

Advancing Cancer Treatment Research

Universities are frequently integral to groundbreaking advancements in research. At The University of North Carolina at Chapel Hill, the Lineberger Cell Expansion Center is devoted to cancer treatment research.

This 7,500 square foot renovation integrated office and laboratory support space in conjunction with 2,900 square feet of cleanroom space, divided into six cell expansion rooms.

In the expansion rooms, cellular material is expanded and transduced within biosafety cabinets, then treated with various therapeutic chemicals to test the effects. An equipment room housing a mixture of ultralow and liquid nitrogen freezers is also included within the cleanroom area to house samples. Adjacent to the cleanroom, a clinical storage room is provided with an attached utility room for glass-washing and cold storage.

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Clark Nexsen Science + Technology / 01 Innovation & Discovery

Innovation in Manufacturing

Efficient manufacturing is critical to pharma bottom lines. In an industry that relies on visionary investors, companies strive to be transparent, innovative, and fiscally responsible.

Humacyte's tenant upfit is centered on transparency and how they manufacture their product. Geared to grow their investor base by highlighting cutting-edge technology, the manufacturing facility supports semiautomatic production of the company’s Humacyl™ product family beginning with the HAV product line. This product line is a tissue-engineered vascular prosthesis intended as an alternate to autologous tissues or synthetic grafts, manufactured using a unique process that involves state-of-the-art tissue engineering techniques.

The manufacturing space is designed to accommodate the process, which begins with accepting and storing buffers and media (produced off-site and delivered by means of re-usable totes), upstream 2D manufacturing, 3D vessel manufacturing, de-cellularization, and finally packaging and labeling functions ahead of shipping product for use in the healthcare industry.

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“

I found the design team and project teams from the Clark Nexsen organization to be not only consummate professionals, but also engaged, interactive, and highly responsive to feedback and direction from me the client throughout the project.�

- Dr. Ted Lithgow, COO, Humactye, Inc.

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Clark Nexsen Science + Technology / 01 Innovation & Discovery

Glass Labs: Greenhouses Solving Global Problems The research conducted in greenhouses around the world has the potential to meaningfully impact human health on a global level. These "glass labs" support leading scientists as they explore agricultural and pharmaceutical advances.

Our extensive greenhouse design experience encompasses work with the private organizations such as Bayer, BASF, and Medicago as well as public clients including the USDA, the University of Georgia, Old Dominion University, and East Carolina University. Our projects include: ++ BASF Headhouse & Greenhouse Expansion ++ Bayer Greenhouse 1 ++ Bayer Greenhouse 5 ++ Bayer Greenhouse 6 ++ Medicago Production Greenhouse ++ University of Georgia Turfgrass Research & Education Facilities (three greenhouses/sites) ++ USDA Greenhouse, Charleston 22

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02 ENVIRONMENT & AMENITIES Retaining & Attracting Top Talent

The BioProcess Innovation Center utilizes transparency within the building and to the outdoor environment to enhance occupants' sense of wellbeing and connectivity.

The two story lobby space, with its overlooking walkway, demonstrates how this effort creates opportunities for impromptu, authentic social interaction.

In the competition for scientific talent, the workplace presents a unique playing field – where the tactics range from location, to amenities, to creative freedom. As biotech and pharmaceutical companies seek to appeal to a new generation of scientists, the definition of a high quality workplace continues to shift, emphasizing public space and a strong sense of community.

Architecturally, these are not new concepts, but aligning them with the parameters of schedule and budget that are ever-present in S+T facility design presents unique challenges.

The design of S+T facilities that appeal to top talent involves the intersection of environment and amenities. Crafting campuses and buildings that are engaging, operationally efficient, and respectful of their surrounding environment advances multiple business objectives. In the following pages, we'll explore how to create a vibrant, active R&D community.

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Clark Nexsen Science + Technology / 02 Environment & Amenities

Connectivity Enhances Workplace Community

With a design that is responsive to its site and emphasizes indooroutdoor connectivity, the BioProcess Innovation Center for FUJIFILM Diosynth Biotechnologies balances public and private spaces to support a sense of community in the workplace.

Taking advantage of the facility's natural, wooded setting, the exterior and walkway act as an intentional extension of the building. Outdoor courtyards provide opportunities for connectivity with other people as well as with the surrounding natural setting. On the interior, the use of transparency, a balance of public spaces, and the two-story lobby with its overlooking walkway create opportunities for impromptu, authentic social interaction. By activating the BioProcess Innovation Center through interior and exterior views and environments crafted for collaboration, the design translates to higher degrees of human wellbeing and satisfaction.

AIA North Carolina Honor Award

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Environment & Resiliency

The new catchphrase in conversations about sustainability, "resilient design" takes awareness of and respect for the surrounding environment to a new level.

The UNC Coastal Studies Institute is a highly sustainable, resilient research building. Located in the Outer Banks of North Carolina, CSI’s program enables the structure to withstand sea level rise and other future realities of the coastal environment.

"The design has already established a reputation for beauty and functionality," said Nancy White, Executive Director of the Coastal Studies Institute, "it will serve us well in recruiting the best faculty, providing the best experience for the faculty and students, and conducting top-notch multi disciplinary, integrative, inter-institutional research."

LEED Gold Certified by the USGBC; AIA North Carolina COTE Award for Sustainability Chicago Athenaeum International Architecture Award for Best New Global Design AIA North Carolina Design Award AIA Virginia Design Award

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Clark Nexsen Science + Technology / 02 Environment & Amenities

Smart Buildings

The future of smart buildings promises a user and owner experience that is transformed by technology. From information distribution, to analytics, to energy efficiency, this technology has the potential to leave no aspect of building operation untouched.

Fitts-Woolard Hall at NC State University integrates smart building technology that supports key areas of energy conservation and occupant safety. Lighting and HVAC controls systems are integrated and can be viewed in a common interface for better oversight, while the fire alarm system leverages the "bulletin board" video monitors throughout the facility to alert occupants in the event of a fire (in addition to traditional alarms). Additionally, students and faculty will have access to information about the building's energy consumption and sustainability, also through the building's video monitors.

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Clark Nexsen Science + Technology / 02 Environment & Amenities

Attracting S+T Tenants

Developers in the science and technology market are focused on creating environments that attract S+T tenants, which is fundamentally tied to creating those environments in a way that promotes a high-quality of work and human interaction.

Cutting edge research and office space is an expectation for companies in the S+T market sector. What can distinguish a developer's facility and attract tenants lies in capitalizing on shared, public, and outdoor space in a way that positively impacts their business.

Fostering collaboration between researchers is key to innovation and advancement. As a result, S+T companies are looking for facilities that promote the exchange of ideas both in and out of laboratory space. Outside-the-box amenities such as beer gardens, game spaces, and rooftop patios are contributing to a vibrant, social environment that transforms the office facility into a hub of activity beyond core work hours. Restaurants, coffee shops, and fitness centers are being introduced in new and innovative ways that enhance their appeal and cost-effectiveness.

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Amenities that Appeal to Top Talent

Attracting and retaining scientific talent is a top priority in a highly competitive employment landscape.

Companies whose offices reflect an engaging, positive culture and a focus on what matters to employees stand to win.

While we can't define your corporate culture, we can help you define and create amenities that will make you stand out. From gyms, to cafes, to beer gardens, thinking outside-the-box to establish amenities that are both unique and purposeful is key. These spaces aren't just nice to have, they intentionally foster connections between employees and promote collaboration and wellbeing. Pictured right, integrating a brewery on site is both unexpected and positive for the campus environment.

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Clark Nexsen Science + Technology / 02 Environment & Amenities

Creating Urban Appeal & Activity

For suburban R&D campuses, activating the environment and experience for tenants and their employees is key to success. To create a sense of urban activity, campuses must integrate mixed-use attributes such as coffee shops, food trucks, and appealing outdoor space.

By functioning as self-contained mini-cities, suburban campuses can create a vibrant, engaging environment for tenants and their employees.

To simulate the urban experience and the sense of action that accompanies it, the integration of these mixed use elements must be innovative.

Not just dining - but an active space for a variety of food trucks; a brewery; a connected cafe. By thinking outside-the-box about amenities on campus, developers can support their tenants in compelling interaction and building collaboration between scientists.

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“

I truly appreciate the design of our lab space.

The view of the forest provides such a peaceful energy to the lab. It's like our own little piece of heaven.�

- Tasha Jones, FUJIFILM Diosynth Biotechnologies USA, Inc.

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03 PARTNERSHIPS & DELIVERY Realizing Your Vision

Bayer stands as an example of a strong partnership that has led to the completion of many successful design and construction projects.

In the world of S+T, time is money.

Regardless of complexity, companies in this sector need their facilities to be designed, constructed, and operational as rapidly as possible.

Today more than ever, public and private clients in the science and technology sector are seeking ways to fast track project design and construction while controlling costs. Strong, effective partnerships are central to successfully executing fast track, design-build projects. As a firm that has contracted in multiple ways to deliver design services, we understand the balance between client, developer, tenant, contractor, and designer. By working collaboratively and constantly seeking opportunities for innovation, S+T facilities can meet timelines, budgets, and still exceed expectations.

Additionally, these public and private clients are increasingly looking for opportunities to work together, collaborating on groundbreaking research and sharing the financial burden of new facilities. Public-private partnership (P3) is one of the hottest topics in project delivery, and for good reason. Done right, P3 can be incredibly successful. The following pages explore successful partnerships and project delivery approaches.

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Working with Bayer to Feed a Hungry World

Our partnership with Bayer now spans nearly a decade and has delivered nearly 50 projects.

Since 2010, Bayer has invested nearly $150 million in their Research Triangle Park (RTP) campus, which now houses both their North American Headquarters as well as their Global Seeds Headquarters. This investment represents meaningful impact for RTP in terms of job creation and economic success as well as the world at large, as Bayer develops technologies to meet the world’s growing demand for food.

In 2008, the Clark Nexsen partnership with Bayer began on a small renovation, creating a space that would serve as a telepresence room enabling their employees in RTP to connect with colleagues all over the world. In the years since then, our two companies have partnered on nearly 50 projects, spanning research greenhouses, laboratory renovations and expansions, new lab buildings, office space and infrastructure upgrades, and seed and chemical processing facilities – contributing to Bayer’s position as a global leader in agricultural technology.

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We worked with Clark Nexsen on a very challenging fast paced design/build project.

Clark Nexsen deploys a very effective and efficient team approach which enables all specialists to fully understand the overall project requirements and keep abreast of project status and critical issues. Clark Nexsen was found to be knowledgeable, prepared, engaged and responsive whenever necessary.�

- Michael Wanner, CFO & Executive President of Operations, Medicago

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Clark Nexsen Science + Technology / 03 Partnerships & Delivery

Public-Private Partnerships (P3)

Arguably the hottest topic in alternative delivery methods these days, publicprivate partnerships provide an opportunity for the private and public sectors to come together to finance and deliver capital projects.

The world of R&D has long thrived on partnerships between private companies and research institutions.

P3 for S+T takes that partnership to the next level with developers engaging with both S+T companies and colleges and universities to develop facilities that promote collaboration and discovery.

In the case of the Health Sciences Center, Henderson County took a leadership role in facilitating the development of a facility to serve Pardee Hospital, Wingate University, and Blue Ridge Community College.

This integrated environment emphasizes transparency and creates opportunities for students, teachers, and patients to engage with each other.

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Clark Nexsen Science + Technology / 03 Partnerships & Delivery

Developer-Led DesignBuild

Delivered via developer-led designbuild, Medicago's Research Triangle Park facility was completed, from design through construction, in just 11 months.

Partnership is never more important - or more complex - than in a developer-led design-build. Working with a designer who is responsive and collaborative is key to meeting the expectations of all parties - developer, tenant, and contractor. The 97,000 square foot Medicago facility, encompassing greenhouses, labs, and office space, reflects a successful partnership that delivered on design-build goals for speed and cost control without sacrificing technical quality.

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Clark Nexsen Science + Technology / 03 Partnerships & Delivery

Single-Source Design Resource for BASF

BASF leverages our capability as a streamlined, single-source for design services to meet ongoing lab upfit and industrial needs.

BASF’s long partnership with Clark Nexsen now spans more than 40 projects including master planning, R&D expansion, lab upfits, and manufacturing and industrial projects. In addition to significant projects including a campus master plan and headhouse and greenhouse expansion, our team has worked closely with BASF on many lab upfits. Frequently, these involve the renovation and repurposing of one to four lab spaces to meet the research needs of incoming users. As a trusted partner, we serve BASF by seamlessly completing projects that enable their R&D efforts.

Our industrial engineering team also provides regular support for BASF’s manufacturing facilities.

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Nimble & Flexible Relationship Structure

The world of S+T design and construction changes rapidly, and we are prepared to support you by changing with it. Our experience working with developers, contractors, and directly with clients benefits all parties.

The BioProcess Innovation Center for FUJIFILM Diosynth Biotechnologies has its roots in a direct relationship between Clark Nexsen and FUJIFILM. During the design process, the client elected to explore a land-lease and partner with a developer, at which time we supported them by making an introduction to Alexandria Real Estate Equities. We focus on a contract and structure that meets our client's needs, and our experience working with multiple parties makes this a seamless effort.

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04 ABOUT Firm Overview & Accolades

Clark Nexsen is a transdisciplinary architecture and engineering firm providing innovative design solutions to U.S. and global clients. With 10 offices spanning Virginia, North Carolina, Georgia, and Texas, our people work to shape the future by discovering opportunities to transform the way we live in and experience our world. Leveraging the strength of multiple disciplines, we actively collaborate across intersecting areas of expertise to gain new perspectives, inspire innovation, and deliver high-performing, sustainable projects.

Our firm of more than 400 professionals delivers solutions for architecture, engineering, planning, interior design, and landscape architecture. Our expertise encompasses science and technology, higher education, K-12, healthcare, institutional, and public work for local and national clients.

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Clark Nexsen Higher Education / 04 About

Select Accolades

To develop innovative solutions for our clients, we remain committed to excellence in every aspect of our work.

Since 1920, this commitment to the client experience and exceptional design quality has been reflected by our many repeat clients and industry accolades. ++

2018 ARCHITECT Magazine Top 50 Design (#20)

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2017 AIA NC Firm of the Year

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98 AIA design awards

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325+ total design awards

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#24 Building Design + Construction’s list of the Top Architecture/Engineering Firms

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#24 Building Design + Construction’s list of the Top S+T Architecture Firms

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Building Design + Construction’s Top S+T Architecture Firms Ranking

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Clark Nexsen Higher Education / 04 About

Integrated Design Enhances Sustainability

We believe it is our social responsibility to advance our communities through innovative, sustainable design.

Sustainability and green design must positively impact long-term environmental, economic, and social roots.

As a transdisciplinary architecture, engineering, and planning firm, Clark Nexsen offers a collaborative, solutions-oriented design approach that addresses integral systems, structures, and finishes of a project - and environmental, economic, and social impacts. We refer to this approach as 'Integrated Design.' In addition to the LEED Rating System, our staff is experienced with Green Globes, Energy Star, the Institute for Sustainable Infrastructure’s Envision tool, and other mechanisms for designing sustainable outcomes.

By leveraging the intersections of our diverse knowledge base, we embrace an integrated design approach that has led to the delivery of more than 120 LEED certified, pending, or self-certified projects.

Through our commitment to the AIA 2030 Challenge, we are holding ourselves accountable to continue innovating and implementing new sustainable strategies.

87 LEED Certified projects complete; 120+ projects are LEED Certified, pending certification, or self-validated

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Clark Nexsen Higher Education / 04 About

Select Science + Technology Clients

Alexandria Real Estate Equities Argos Therapeutics Aurobindo Pharma USA BASF Bayer bioMĂŠrieux Board of Regents - University System of Georgia Braeburn Pharmaceuticals Chimerix Duke University FUJIFILM Diosynth Biotechnologies Germanna Community College GREER Humacyte KBI Biopharma LabCorp Longfellow Real Estate Partners Longwood University Mayne Pharma Medicago Moultrie Technical College National Institutes of Health North Carolina State University Novartis

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Old Dominion University Pearl Therapeutics Pfizer Raychem Corporation Reichhold Research Triangle Institute Savannah River National Laboratory Scynexis, Inc. Texas State University The University of North Carolina at Chapel Hill U.S. Coast Guard U.S. Department of Agriculture (USDA) UNC Coastal Studies Institute UNC Lineberger Cancer Center Underwriters Laboratories University of Georgia University of North Carolina at Wilmington Virginia Institute of Marine Science Virginia Military Institute Virginia Tech Wake Technical Community College Western Carolina University Xanofi Zoetis

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Together we discover, inspire, and shape ideas that transform our world.

clarknexsen.com