Bending the cost curve through virtual diabetes care managment

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Bending the cost curve through virtual diabetes care management

R E A L W O R L D R O I A N A L Y S I S
2 | Cecelia Health - Health Plan ROI Analysis © 2023 Cecelia Health. All rights reserved. Outline Executive Summary 3 Figure 1 – Medical PMPM Costs for Members Enrolled vs. Not Enrolled 3 Background & Objectives .................................................................................................................... 4 Methodology ......................................................................................................................................... 4 Inclusion Criteria ............................................................................................................................. 4 Table 1: Members Enrolled with Continuous Enrollment 4 Population Profiles Prior to Matching .......................................................................................... 5 Table 2: Pre-Matched Means: Enrolled vs. Not Enrolled 5 Propensity Score Matching ............................................................................................................ 6 Table 3: Covariates Used for PSM 6 Equation 1: Generalized Logistic Regression Formula ......................................................... 6 Equation 2: Truncated Logistic Regression Formula Used for PSM 6 Figure 2: Side-by-side Distribution of Propensity Scores of Enrolled vs. Not Enrolled Populations .............................................................................................. 7 Table 4: Post-Matched Means: Enrolled vs. Not Enrolled 8 Table 5: Suggested Interpretation of Cohen's d Effect Size.................................................. 9 Figure 3: Standardized Mean Differences of Matched Covariate Used in PSM Model 9 Difference-in-differences ............................................................................................................. 10 Equation 3: PMPM Equation for Difference-in-differences 10 Equation 4: Six-month Cost Differential Equation for Difference-in-differences ...............10 Equation 5: Gross Savings Equation for Difference-in-differences 10 Equation 6: Costs Equation for Difference-in-differences ................................................... 10 Equation 7: ROI Equation for Difference-in-differences 10 Results ................................................................................................................................................. 11 Table 6: Difference-in-differences Analysis.......................................................................... 11 Table 7: Claims Costs, Where Diabetes is Primary Diagnosis 11 Table 8: Claims Costs by Place of Service ........................................................................... 12 Conclusion 12 References 12

Executive Summary

A Midwest health plan wanted to reach, engage, and empower more members living with diabetes through personalized virtual care. With Cecelia Health, the plan implemented a six (6)-month diabetes management solution that included clinical support and education from experienced Certified Diabetes Care & Education Specialists (CDCES). The Cecelia Health clinical team is specially trained to help individuals better understand how to selfmanage their condition. They build relationships that foster trust to address individual preferences as well as unique barriers to medication and care plan adherence, including social determinants of health.

Members enrolled in the Cecelia Health program realized lower medical per member per month (PMPM) costs compared to rising costs among those not enrolled as shown in Figure 1, and:

 38% reduced diabetes claims cost over six months compared to nonenrolled members, where diabetes was the primary diagnosis

 64% reduction in inpatient costs over six months compared to nonenrolled members

These impacts resulted in a 3.7x return on investment (ROI) for the plan

3 | Cecelia Health - Health Plan ROI Analysis © 2023 Cecelia Health. All rights reserved.
$839 $675 $825 $963 $0 $200 $400 $600 $800 $1,000 Six Month Pre PMPM Six Month Post PMPM Enrolled Not Enrolled
Figure 1 – Medical PMPM Costs for Members Enrolled vs. Not Enrolled

Background & Objectives

Cecelia Health is a virtual specialty medical practice providing holistic, chronic care management across a range of care and conditions. Cecelia Health’s clinicians empower members to understand their disease, remove barriers, and adhere to their medication and treatment plans.

The plan partnered with Cecelia Health to expand and scale their existing diabetes management program in a cost-effective way, launching Cecelia Health’s virtual care platform in February 2022, including:

 Cecelia Health team of Certified Diabetes Care and Education Specialists (CDCES) providing dedicated care management support

 Member engagement over a six (6)-month period

 Personalized and programmatic member journey with timely and relevant curriculum to encourage and reinforce positive behavior change

 Omnichannel outbound member communications

 Eligible members can re-enroll for three (3) months after the initial six (6)-month enrollment with a maximum of three (3) re-enrollments allowed per member Program objectives included improving the member’s understanding of diabetes, reducing HbA1c levels, HEDIS gap closures, improving member satisfaction, and making behavior and lifestyle changes that lead to long-term health outcomes and quality of life. These objectives should impact lowering healthcare cost such as reduction in medical spend and inpatient cost. The purpose of this study is to analyze and quantify the cost benefits of the virtual program and determine the return on investment to the health plan

Methodology Inclusion Criteria

To be eligible for the case study, members must have enrolled in or been referred to (but not enrolled in) the Cecelia Health diabetes management program between February 1, 2022, and March 31, 2022. This date enrollment date for those enrolled and referral date for those referred is the “program date.” Members must also have continuous enrollment with the plan for six months prior to and including the month of enrollment with Cecelia Health and six months post the month of enrollment with Cecelia Health. After applying continuous enrollment constraints, the enrolled population loses just 15 members as seen in Table 1

4 | Cecelia Health - Health Plan ROI Analysis © 2023 Cecelia Health. All rights reserved.
Cohort Members Members with Continuous Enrollment Enrolled 179 164
Table 1: Members Enrolled with Continuous Enrollment

Population Profiles Prior to Matching

Prior to running propensity score matching (see Propensity Score Matching section below), exploratory data analysis was performed to compare the member population enrolled in Cecelia Health to those members referred but not enrolled. Table 2 shows the mean values for the metrics that are available to be used in the propensity score matching model prior to matching. All spend values have been transformed into a six-month PMPM for ease of comparison.

An immediate takeaway is that the members who enrolled in Cecelia Health tend to:

 Be nine (9) years older on average, more likely to be on Medicare

 Have an average total medical PMPM of ~$838 prior to enrollment

 Have an average inpatient PMPM of ~$291 prior to enrollment

 Have an average amount of inpatient visits at twice the rate of those not enrolled

5 | Cecelia Health - Health Plan ROI Analysis_18Jul2023
Metric Enrolled Means NotEnrolled Means Member Age (Years) 67.2 58.2 Gender - Female 50.6% 52.8% Plan - Medicaid 17.7% 61.5% Plan - Medicare 81.7% 33.9% Language - English 86.0% 81.9% Language - Spanish 9.8% 1.9% Language - Arabic 0.0% 0.9% Language - Hmong 0.0% 3.4% Language - Somali 1.2% 5.7% Language - Vietnamese 0.0% 0.7% Total Medical Spend - Pre* $838.55 $771.17 Diabetes Medical Spend - Pre* $108.39 $79.50 Chronic Kidney Disease Medical Spend - Pre* $0.00 $0.39 Cancer Medical Spend - Pre $3.52 $2.41 Surgical Medical Spend - Pre* $3.06 $17.35 Inpatient Medical Spend - Pre* $290.84 $190.72 Emergency Dept. Medical SpendPre* $29.24 $48.73 Outpatient Medical Spend - Pre* $100.26 $108.49 Urgent Care Medical Spend - Pre* $2.68 $2.10 Office Medical Spend - Pre* $129.19 $123.74 Telehealth Medical Spend - Pre* $7.71 $8.05 Inpatient Visit Count - Pre 1.4 0.7 Emergency Dept. Visit Count - Pre 0.6 0.8 Outpatient Visit Count - Pre 2.6 2.4 Urgent Care Visit Count - Pre 0.2 0.1 Office Visit Count - Pre 6.0 5.4 Telehealth Visit Count - Pre 0.3 0.4
to PMPM
Table 2: Pre-Matched Means: Enrolled vs. Not Enrolled
*Transformed

Propensity Score Matching

To measure the outcomes of the population that enrolled in the Cecelia Health diabetes management program against those who did not choose to enroll, a statistical technique known as propensity score matching (PSM) was leveraged to create a population of those who did not enroll that looks statistically similar to the population that did enroll. PSM uses logistic regression to calculate the log-likelihood that a member would enroll in the Cecelia Health program

The logistic regression regresses demographic information, total medical spend, medical spend by disease state, total healthcare utilization, and healthcare utilization by disease state to calculate the log-likelihood of a member enrolling in the Cecelia Health program. The loglikelihood of an individual who elected to enroll in the Cecelia Health program was then paired with an individual who did not enroll but, had the same or similar log-likelihood of enrolling with the understanding that the individuals resemble one another across many dimensions.

The generic mathematical representation of the logistic regression is represented by Equation 1. A truncated representation of the logistic regression model used for this study is represented by Equation 2 with Table 3 representing all the covariates (or member characteristics) used. Prior to PSM, all continuous covariates are scaled between 0 and 1.

Equation 1: Generalized Logistic Regression Formula

+

+ �������� ��������

Equation 2: Truncated Logistic Regression Formula Used for PSM

enrolled���� = ����0 + ����1 �������������������� ���������������� ���� + ����2

���� + +

Propensity Score Matching Covariates

Member Age

Gender - Female

Language - English

Language - Spanish

Language - Arabic

Language - Hmong

Language - Somali

Language - Vietnamese

Total Medical Spend - Pre

Diabetes Medical Spend - Pre

Chronic Kidney Disease Medical Spend - Pre

Cancer Medical Spend - Pre

Surgical Medical Spend - Pre

Inpatient Medical Spend - Pre

Emergency Dept. Medical Spend - Pre

Outpatient Medical Spend - Pre

Urgent Care Medical Spend - Pre

Office Medical Spend - Pre

Telehealth Medical Spend - Pre

Inpatient Visit Count - Pre

Emergency Dept. Visit Count - Pre

Outpatient Visit Count - Pre

Urgent Care Visit Count - Pre

Office Visit Count - Pre

Telehealth Visit Count - Pre

6 | Cecelia Health - Health Plan ROI Analysis © 2023 Cecelia Health. All rights reserved.
log ���� 1 ���� = ����0 + ����1 ����1 + ����2 ����2
������������������������������������������������
�������� ���������������� ����������������������������������������ℎ����������������ℎ������������
����
Table 3: Covariates Used for PSM

After PSM, exploratory data analysis looks to ensure the balance between those enrolled in the Cecelia Health program and those not enrolled in the Cecelia Health program is statistically similar. Checking the distribution of propensity scores, or the log-likelihood that a member would enroll in the Cecelia Health program, demonstrates an even distribution between those who enrolled compared to those who did not enroll as seen in Figure 2

The resulting means of the variables used for the model after matching look more similar between those who enrolled in the Cecelia Health program compared to those who did not enroll, as shown in Table 4 The cohorts look much more similar to one another, with the average age of individuals in the cohort measuring as approximately 67 years old, the enrolled cohort having a PMPM within 2% of the not enrolled cohort, fulfilling the parallel slope assumption for the difference-in-differences (see below Difference-in-differences section), and both cohorts having similar emergency room utilization. While the Plan - Medicare and Plan - Medicaid covariates were considered but ultimately excluded from in the model, the prevalence of those plans is much more comparable now between the enrolled and not enrolled cohorts when comparing the balance between Table 3 and Table 4

7 | Cecelia Health - Health Plan ROI Analysis © 2023 Cecelia Health. All rights reserved.
Figure 2: Side-by-side Distribution of Propensity Scores of Enrolled vs. Not Enrolled Populations

Table 4: Post-Matched Means: Enrolled vs. Not Enrolled

8 | Cecelia Health - Health Plan ROI Analysis © 2023
Health.
Cecelia
All rights reserved.
Metric Enrolled Means Not Enrolled Means Member Age^ 67.2 67.9 Gender - Female^ 50.6% 47.0% Plan - Medicaid 17.7% 26.8% Plan - Medicare 81.7% 71.3% Language - English^ 86.0% 82.3% Language - Spanish^ 9.8% 8.5% Language - Arabic^ 0.0% 0.0% Language - Hmong^ 0.0% 0.0% Language - Somali^ 1.2% 0.0% Language - Vietnamese^ 0.0% 1.2% Total Medical Spend - Pre*^ $838.55 $824.95 Diabetes Medical Spend - Pre*^ $108.39 $103.58 Chronic Kidney Disease Medical Spend - Pre*^ $0.00 $0.00 Cancer Medical Spend - Pre*^ $3.52 $3.92 Surgical Medical Spend - Pre*^ $3.06 $44.32 Inpatient Medical Spend – Pre*^ $290.84 $221.51 Emergency Dept. Medical Spend - Pre*^ $29.24 $25.39 Outpatient Medical Spend - Pre*^ $100.26 $160.57 Urgent Care Medical Spend - Pre*^ $2.68 $2.46 Office Medical Spend - Pre*^ $129.19 $140.58 Telehealth Medical Spend - Pre*^ $7.71 $3.52 Inpatient Visit Count - Pre^ 1.39 0.54 Emergency Dept. Visit Count - Pre^ 0.59 0.58 Outpatient Visit Count - Pre^ 2.63 2.36 Urgent Care Visit Count - Pre^ 0.16 0.13 Office Visit Count - Pre^ 5.98 5.80 Telehealth Visit Count - Pre^ 0.29 0.18 *Transformed to PMPM ^Used as covariate in matching

Standardized mean differences (or Cohen’s d) are measured for each covariate used in the PSM model to ensure the differences between each covariate will not have an oversized impact on the analysis. The most common interpretation for standardized mean difference was initially suggest by Jacob Cohen and updated by Shlomo S. Sawilowsky (Sawilowsky, S [2009]). Those values can be found in Table 5

Using this interpretation, it is observed that after matching, the standardized mean differences are all categorized as having a small or very small impact on the analysis as represented by Figure 3

9 | Cecelia Health - Health Plan ROI Analysis_18Jul2023
Effect size d Very small 0.01 Small 0.2 Medium 0.5 Large 0.8 Very large 1.2 Huge 2
Table 5: Suggested Interpretation of Cohen's d Effect Size Figure 3: Standardized Mean Differences of Each Matched Covariate Used in PSM Model

Difference-in-differences

To measure the plan’s return on investment (ROI) for the Cecelia Health diabetes management program, a difference-indifferences was performed. Difference-indifferences attempts to measure the differential effect of the impact the Cecelia Health program has had on those who enrolled versus those who did not enroll but looks statistically similar to those who did. The main assumption for difference-indifferences is the “parallel trend assumption.” For the purposes of this study, the parallel trend assumption is the six (6)month medical spend in the pre-period for the enrolled population compared to the nonenrolled population. PSM is used to ensure the two populations have a similar six (6)month medical spend leading up to the program date.

Equation 3 through Equation 7 represents the difference-in-differences used to calculate the return on investment, where c represents the cohort (enrolled or not enrolled), and t represents the period (pre or post).

Equation 3: PMPM Equation for Difference-in-differences

Equation 4: Six-month Cost Differential Equation for Difference-in-differences

Equation 5: Gross Savings Equation for Difference-in-differences

Equation 6: Costs Equation for Difference-indifferences

Equation 7: ROI Equation for Difference-indifferences

������������������������������������������������������������������������

10 | Cecelia Health - Health Plan ROI Analysis © 2023 Cecelia Health. All rights reserved.
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6����������������ℎ���������������������������������������������������������������� = ��������������������� ,����=������������ �������������������� ,����=���������������� � ∗ ����������������������������������������������������,���� ∗ ����������������ℎ���������������������������������������������������������������������������������������� ,����
������������������������������������������������ = 6����������������ℎ��������������������������������������������������������������������=�������������������������������� 6����������������ℎ��������������������������������������������������������������������=��������������������������������������������
���������������������������������������� = ∑ ������������������������������������������������=�������������������������������� ∗ 390 + ∑ ��������������������������������������������������������=�������������������������������� ∗ 195
= ������������������������������������������������ ����������������������������������������

Results

Members who enrolled in February and March of 2022 demonstrate a six (6)-month total cost differential of $161,376. Those who did not enroll had a six (6)-month cost differential of -$135,792. The difference between the two is a gross savings of $297,168. For the enrolled population, there were 164 enrollments and 82 reenrollments for a total cost of $79,950. This reveals a return-on-investment of 3.72 : 1.

Table 6 is a tabular representation of the equations laid out above (see Difference-in-differences section)

Diving deeper into the outcomes, Table 7 represents the claims costs for the enrolled and not enrolled population where diabetes is the primary diagnosis. Both cohorts have similar PMPMs in the pre period. Those enrolled saw a 16% reduction in their PMPM in the post period where those not enrolled saw a 22% increase in PMPM.

Table 8 represents the claims costs for the enrolled and not enrolled population by place of service. The aim of the Cecelia Health diabetes program is to help members better manage their diabetes and other comorbidities to reduce the cost burden of inpatient and emergency department utilization. Both cohorts have elevated PMPMs for inpatient hospital and emergency room places of service in the pre period. This is expected, as individuals who opt into disease management programs often have had an inpatient admission or an emergency department visit prior to enrollment. The enrolled population realized a 71% reduction in inpatient hospital PMPM compared to only a 7% reduction for the not enrolled population. The enrolled population also demonstrated a 3% reduction in emergency room PMPM compared to a 24% increase for the not enrolled population.

11 | Cecelia Health - Health Plan ROI Analysis © 2023 Cecelia Health. All rights reserved.
Cohort Members PMPM Pre (6 months) PMPM Post (6 months) 6 Month Cost Differential Gross Savings Costs ROI Enrolled 164 $839 $675 $161,376 $297,168 $79,950 3.72x Not Enrolled 164 $825 $963 -$135,792
Table 6: Difference-in-differences Analysis
Cohort Members Diabetes Claims Cost Diabetes PMPM Diabetes PMPM Reduction PMPM Difference Pre Post Pre Post Enrolled 164 $98,301 $82,616 $99.90 $83.96 15.96% 37.97% Not Enrolled 164 $95,102 $116,037 $96.65 $117.92 -22.01%
Table 7: Claims Costs, Where Diabetes is Primary Diagnosis

Conclusion

Cecelia Health's diabetes management program has shown an incredible 3.7x return on investment for the plan through reductions in costs for diabetes (16%), inpatient (71%) and emergency department (3%) claims. The ability to bend the cost curve for at-risk populations is the result of personalized clinical support and education, increased health accountability realized through the setting and meeting of SMART goals, behavior and lifestyle changes, and increased care plan adherence

References

Sawilowsky, S (2009). "New effect size rules of thumb". Journal of Modern Applied Statistical Methods. 8 (2): 467–474. doi:10.22237/jmasm/1257035100. http://digitalcommons.wayne.edu/jmasm/vol8/iss2/26/

About Cecelia Health

Cecelia Health is a virtual specialty medical practice for proactive health condition management. Since 2009, our clinician-led, tech-enabled practice supports the clinical, social, and behavioral needs of patients while leveraging rich sources of data for insights to focus care and measure outcomes. The clinician-patient relationships we build result in high engagement rates, increased patient satisfaction, and durable health outcomes. Our solution is adaptable and scalable to health organizations such as health plans, health providers, retail healthcare, and life sciences.

12 | Cecelia Health - Health Plan ROI Analysis © 2023 Cecelia Health. All rights reserved.
Place of Service Cohort Members Medical Claims Cost PMPM PMPM Reduction PMPM Difference Pre Post Pre Post Inpatient Hospital Enrolled 164 $286,184 $82,405 $290.84 $83.74 71.2% 64.2% Not Enrolled 164 $217,749 $202,448 $221.29 $205.74 7.0% Emergency RoomHospital Enrolled 164 $25,032 $24,193 $25.44 $24.59 3.3% 27.6% Not Enrolled 164 $19,949 $24,794 $20.27 $25.20 -24.3%
Table 8: Claims Costs by Place of Service

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