Big Arrow | Patient Advocacy Credentials

NYC / SF / NICE

Patient Advocacy

Agency Credentials

Hello!

Welcome to Big Arrow Group

As a strategic planning and communications agency, we distinguish ourselves by our focus on rare disease and specialized care. We rely on unique insights that help our clients connect with and activate their target audiences. Our mission of direction & velocity. See how it sets us apart.

We’re Proud of What Makes Us Different

We focus on the intersection of rare and care. Our difference is born from 21 years of experience in rare disease and patient advocacy. We bring a full-spectrum understanding, from the science to the solution to the soul of healthcare itself, in order to improve the infrastructure of care itself.

Care is not just treatment — it's everything around it. We mobilize physicians, healthcare teams, systems, and communities to improve how people live with rare disease. That means orchestrating every brand, communication, and support that makes every interaction count. For us, action is advocacy practical, purposeful, and personal.

We commit to empathize, innovate, and go further, faster. In rare disease, the challenges are known patient identification, professional education, and trust. What sets us apart is our ability to integrate every resource to move from insight to impact quickly and meaningfully. As the category grows, so does the need to distill complexity into clarity. We lead — so patients can move forward.

We Know Rare

20 years of rare disease experience

HCP, patient, payer comms, branded and non -branded

Pre-marketing conditioning and launches

Extensive partnership with patient organizations New digital applications to find, convert and support patients

(Amicus)

bullosa SD-101 - (Amicus)

(Sanofi)

(Amicus)

(Sanofi)

(Pre -transplant) Idefirix (Hansa)

(Biomarin)

Infantile Spasms Epilepsy

(Pyros)

Nephropathic cystinosis Procysbi (Horizon; Chiesi)

Niemann-Pick Type C In development (Amicus)

(Sanofi)

+ Opfolda (Amicus)

(Biogen)

We Know Care

Experience with all forms of healthcare delivery and content development

Patient Advocacy

Support along the entire patient journey

General and specialized hospitals

Health technology, diagnostics and social media

Healthcare Delivery Payers Care/ Support

Empathy Is Our Foundation for Activating Patient Groups

We rely on our own extensive body of ethnographic research to truly understand patient and family experiences to address the needs of the rare disease community.

We understand patient advocates’ influence on decisionmaking, from drug development to reimbursement to raising awareness.

• We overlay our knowledge of regulatory rules, limitations, and opportunities, in both the US (FDA) and Europe (EMA), which include CHMP, HTA, and its scientific committees

We identify where we can intervene to encourage patient engagement efficiently with tailored messaging, tactics, content, and social media.

Big Arrow possesses deep experience with many advocacy groups in the US and Europe, including agency -of-record assignments.

We apply our own clinical and commercial experiences to help you inform and educate more physicians; and to find, start, and keep more people with a rare condition on therapy.

Trends in Patient Advocacy

Findings and insights that are grounded in two decades of rare disease advocacy experience – what we're seeing, shaping, and learning from our ongoing work with patients, caregivers, and advocacy leaders.

1. From Isolation to Belonging

Rare disease patients, once scattered and unseen, are increasingly finding each other through digital platforms and forming empowered, self -sustaining communities

2. Advocacy Must Shift from Crisis to Momentum

Traditional messaging around struggle and scarcity is giving way to narratives of progress, hope, and collective achievement, reshaping how organizations communicate their value

3. The Rise of Universal Topics in Rare Storytelling

Themes like adolescence, gender-specific experiences, and accessibility are creating common ground across disease states, enabling more inclusive and engaging advocacy.

4. Ownership Is the New Empowerment

Patients and caregivers are no longer passive recipients of information—they want tools to selfadvocate, read clinical studies, and participate in their care journeys

5. Emotional Intelligence Is the New Competitive Advantage

Healthcare communication is moving beyond data to storytelling that balances empathy, optimism, and credibility, especially when addressing overlooked or stigmatized conditions

6. AI Is Reshaping Content, Outreach, and Understanding

From SEO to patient education, AI is enhancing how content is created, targeted, and translated into engagement across all health conditions.

7. Omnichannel Advocacy Is Becoming Essential

Reaching patients requires a mix of organic social, paid search, peer platforms, and educationdriven tools—single-channel strategies no longer suffice in today's advocacy ecosystem.

8. Unprecedented cuts in medical research only increases the competition for less money

With a 40% reduction in NIH funding, rescinding grants, and the gradual dismantling of the FDA, it falls upon patient advocates to take a greater, more vocal role in influencing public policy.

We Optimize Online Engagement to Find, Start, and Keep Patients

Our teams offer omni-digital marketing strategy, activation, and optimization services to raise disease brand awareness and decrease time to diagnosis.