The Essential Guide to Primary Sclerosing Cholangitis by Bertus Eksteen

Primary Sclerosing Cholangitis is a chronic liver disease that affects the bile ducts, causing inflammation and scarring that can ultimately lead to serious liver damage Understanding Primary Sclerosing Cholangitis is vital because it often progresses silently, making early detection challenging As explained by Bertus Eksteen, this disease is characterized by the gradual narrowing and obstruction of

bile ducts inside and outside the liver, impairing bile flow, a fluid essential for the digestion and absorption of fats Over time, the bile buildup causes damage to liver cells, leading to fibrosis and cirrhosis

The exact cause of Primary Sclerosing Cholangitis remains unclear, but it is believed to involve an abnormal immune response that triggers inflammation in the bile ducts This condition frequently occurs alongside inflammatory bowel diseases, especially ulcerative colitis, suggesting a link between immune system dysfunction and the disease Symptoms may develop slowly, including fatigue, itching, jaundice (yellowing of the skin and eyes), abdominal pain, and fever or chills due to bile duct infections. Unfortunately, many patients are diagnosed during routine testing for abnormal liver function or after complications arise

Diagnosing Primary Sclerosing Cholangitis involves a combination of blood tests to check liver enzymes, imaging techniques like magnetic resonance cholangiopancreatography (MRCP), and sometimes liver biopsy to assess the extent of damage While this disease has no cure, managing symptoms and slowing progression are key goals Treatments may include medications to reduce itching, antibiotics to control infections, and procedures to open narrowed bile ducts. In advanced cases, liver transplantation may become necessary

Living with Primary Sclerosing Cholangitis requires ongoing medical care and monitoring to detect complications such as bile duct cancer or liver failure Patients are encouraged to maintain a healthy lifestyle, avoid alcohol, and work closely with their healthcare providers. Research continues to explore new therapies and better understand the disease mechanisms

Primary Sclerosing Cholangitis is a complex condition that demands awareness and careful management to improve quality of life and outcomes Early diagnosis and proper care can help patients navigate this challenging disease