MISOPROST Tablet Composition Each tablet contains : Misoprostol (1% ) 20 mg. Equivalant to 200 mcg misoprostol 100% .
Related Articles ( 2019 ABORTION PILLS � Cytotec ⢸ Misotac ♀ EGYPT ) / Click here. Properties Misoprostol is a synthetic analogue of alprostadil (prostaglandin E1 which is used in the prophylaxis and treatment of peptic ulcers, particularly those induced by non steroidal inflammatory drugs (NSAIDS). Following oral administration, Misoprost (misoprostol) is rapidly absorbed and metabolised to its active form (misoprostol acid). Misoprost (misoprostol) has both anti secretory ( inhibiting gastric acid secretion) and mucosal protective properties . NSAIDS inhibit the synthesis of prostaglandin. the difficiency of which within the gastric mucosa may lead to diminishing bicarbonate and mucus secretion and may contribute to mucosal damage . In addition to its anti-secretory activity, Misoprost can increase bicarbonate and mucus production . Indications Misoprost (Misoprostol) is indicated for the prevention of NSAIDS (non steroidal anti-inflanunatory drugs, including aspirin)- induced gastric ulcers in patients at high risk of complications from gastric ulcer, eg. the elderly and patients with concomitant debilitating disease, as well as patients at high risk of developing gastric ulceration, such as patients with a history of ulcer, It has not been shown to prevent duodenal ulcers in patients taking NSAIDS. It should be taken for the duration of NSAID therapy. It has been shown to prevent gastric ulcers in controlled studies of three months' duration . It had no effect, compared to placebo, on gastro-intestnal pain or discomfort associated with NSAIDS use.
Contraindications
Allergy to prosraglandins . Pregnancy .
Side Effects Diarrhea, abdominal pain, flatulance, dyspepsia, nausea, vomiting, skin rashes, headache, constipation. Gynecological disorders include spotting, cramps, menestrual disorder, hypermenorrhea, dysmenorrhea, Post-menopausal vaginal bleeding .
Precautions and warntngs Misoprost should not be given to patients who are pregnant or who may become pregnant because of its abortifacient property . Misoprost is not excreted in human milk since it is rapidly metabolized throughout the body . However, it is not known if the active metabolite misoprostol acid is excreted in human milk . As such Misoprcst should not be administered to nursing mothers because the potential excretion of the active metabolite could cause significant diarrhea in nursing infants .
Dosage and administration The recommended adult oral dose of Misoprost for the prevention of NSAIDS - induced gastric ulcers is 200 mcg four rimes daily for the duration of NSAID therapy . Misoprost should be taken with a meal, and the last dose of the day should be at bedtime. If the 200 mcg dose cannot be tolerated, a dose of 100 mcg can be used .
Storage Store at room temprature away from light and humidity. Pack Carton box containing two PVC / AL. strips of 10 tablets each with inner pamphlet . Produced by : Chemical Industries Development (CID) For Multipharma Co. Original article URL : https://pharmacia1.com/2019/02/17/misoprost-tablets-original-pil/