Reference Analytical Standards and How to Choose Them?

Reference Analytical Standards and How to Choose Them?

Who Uses Reference Materials?

Reference materials or Certificate Reference Material (CRM) are essential for confirming the accuracy and consistency of test data. Reference material has been proven to be suitable for its specific applications in a measuring procedure. A primary factor in its usage is that it is consistent with regard to one or more specific qualities. Reference materials may range from simple crystal structures to pure or blended mixtures. These blends can be highly complicated matrix-based elements that can be utilized for measurement. Composite materials give quality assurance benchmarks to check the accuracy and potentially increase precision through process validation, while quality and quality or solutions can be employed in process validation or provide transparency to the International System of Units (SI).

Reference Materials - SI Units and Metrological Traceability

One of the most important aspects of the range of reference materials is metrological traceability. The original phrase of measurement is SI unit in metrological traceability. SI defines the seven units of measurements that are used for precision. These are the following: ● Length - meter (m) ● Time - second (s) ● Amount of substance - mole (mole) ● Electric current - ampere (A) ● Temperature - kelvin (K) ● Luminous intensity - candela (cd) ● Mass - kilogram (kg)

Reference Materials - The Hierarchy

There are five main grades of qualities in the hierarchy of reference materials. They are primary standards, national metrology, CRMs, analytical standards, reference materials, and research chemicals or grades. For each advanced level the certification level and requirements of traceability increase. The guidelines of ISO comprises ISO Guide 31, ISO 17034 and ISO/IEC 17025.

What Is Measured In Each Grade of Reference Materials?

For the five grades of quality, the identity and purity of the material are analyzed. For the primary standards stability and content are required. Sometimes the analytical standards are quality controlled because the materials obey the ISO Guide 80.

Certificate Of Analysis For Reference Materials

The Certificate of Analysis (CoA) comes after the reference material grade or CRM. There are different quality guidelines that are important to recognize: stability, purity, accuracy, homogeneity, and consistency. ●

Stability - With the help of the real-time study of stability the expiration date is established.

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Accuracy - Differentiated between various independent compositions and compared to a main source or with a certified source.

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Purity - There should be no impurity or corruption and with the good material, it has to be consistent.

Homogeneity - Over a series of flask or vials or ampoules.

Consistency - New pieces are verified with the previous materials for consistency.

Want To Learn More?

Here is a source for further understanding of reference analytical standards.