From Reddit & Quora 12 Questions(Hotly Debated) About NMN(1)

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From Reddit & Quora: 12 Questions(Hotly Debated) About NMN(1)

As we all know, Anti-aging products is a permanent topic and many people study this field for long time, At 2018, there is new drugs for anti-aging and it caused a craze on anti-aging products, this new products called “NMN”. NMN(β-Nicotinamide Mononucleotide) as a new type of anti-aging supplements is very popular. Taking NMN supplements or adding some NMN powder into breakfast is very common seen things since 2020. What information we should know about NMN and how to buy NMN powder online, all questions are concerned by most of people who ready use NMN powder or supplements. Today, we have collect the most discussed topics online from reddit and quora on NMN, hope these answers can help you to know NMN and buy genuine NMN powder online.

What Is NMN Powder?

NMN is short for nicotinamide mononucleotide(CAS:1094-61-7), a naturally occurring molecule present in all species. On the molecular level, it is a ribonucleotide, a basic structural unit of nucleic acid RNA. In form it consists of a nicotinamide group, a ribose and a phosphate group. NMN is a Vitamin B3 (niacin) derivative. It occurs naturally and can be made from dietary sources such as fruits, milk, and vegetables.

In the body, NMN is used to generate nicotinamide adenine dinucleotide (NAD+), a powerful and essential molecule that is found 1

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in every cell of the body. So, Taking NMN powder is one way in which NAD+ levels in the cell can be increased, then achieve the purpose of anti-aging.

For now, there are several ways to produce NMN raw materials in factory, also called NMN powder. As far as I know, I have known 2 ways from factory which manufacture NMN powder: Method 1 for manufacture NMN powder: Catalyst method(Industrial Grade) This manufactured product only for Industrial chemical reaction use, not suitable for human, they will not need to detect the heavy metal, microbiological indicator inside the powder, it is dangerous.

Method 2 for manufacture NMN powder: Enzymatic method(Food Grade) By this method, the NMN powder is safe for people use, and no Reagent residue, even use external standard method to test the quality, the result still no less 98% purity. (there are some products just simple dry the mother liquid to get the powder, and use the HPLC method to test the purity, it is also no less than 98%, but when it use external standard method to measure, then the difference will obvious.

AASraw is a manufacturer factory to produce NMN powder in China and what method we used is enzymatic method, every batch NMN powder will be tested before sell out and the purity shows 99% min, the quality is stable. We have made agreements with several large supplements company and supply NMN powder for them at long term.

There is no doubt that the Enzymatic method is good choice for most of factories. So, please confirm this with your supplier of NMN powder before you buy NMN bulk powder.

What Does NAD+ Have To Do With NMN? NAD stands for nicotinamide adenine dinucleotide. From bacteria to primates, it is one of the most abundant and crucial molecules in 2

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cellular metabolism. In a other way, every body have NAD substance, we would probably die in 30 seconds without the presence of NAD+.

That tell us NAD+ is very important substance for our body, it can support our body work as normal every day.

NAD+ works as a shuttle bus, transferring electrons across one cellular molecule to another.It helping turn nutrients into energy as a key player in metabolism and working as a helper molecule for proteins that regulate other cellular functions. These processes are incredibly important.Other functions of NAD+ include regulating the sleep/wake cycle. NAD+ drives sirtuins to regulate metabolism and maintain stable chromosomes. The molecule also helps with repairing damaged DNA.

So, it is very important to keep NAD+ level of our body. That also told us we get younger by increasing NAD+ level, help us fight aging.

Then what we should increase our NAD+ level?

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As the scientists said, there are three ways to increase NAD+ level: Adjusted dietary regimen. Diets high in fats and low in carbohydrates, such as keto or Atkins-style diet, promote the state of ketosis. When your body is in ketosis, you use fat for energy instead of glucose. This technique increases the ratio of NAD+ to NADH, thereby protecting your body from oxidation.

NAD+ Supplementation. Your body has a finite ability to produce NAD+, so finding a supplement from a reputable producer who offers purity guarantees is a painless way to boost these levels in your body.

These supplements include nicotinamide, nicotinic acid, nicotinamide mononucleotide (NMN), and nicotinamide riboside (NR). 【Nicotinic acid converts to NAD+ through three steps. In the first step, the enzyme NAPRT converts nicotinic acid to nicotinic acid mononucleotide (NAMN). In the second step, the enzyme, NMNAT, converts NAMN to nicotinic acid adenine dinucleotide (NAAD). The enzyme, NAD+ synthetase (NADS) then converts NAAD to NAD+.

NAD+ biosynthesis in the salvage pathway involves nicotinamide’ s conversion to NMN via an enzyme, phosphoribosyltransferase, NMNAT. The enzyme converts NMN to NAD+.】 Practicing intermittent fasting. While severe calorie restriction or long periods of fasting are not recommended for most adults, brief or intermittent fasting can show similar results. Intermittent fasting is a more sustainable way of introducing your body to longer periods without eating, raising your NAD+ levels in much the same way as ketosis.

Unfortunately, a high fat-diet may not be advisable if you have diabetes, heart disease, or increased LDL cholesterol. Similarly, fasting may not be advisable for those with medical conditions and is often difficult to continue over time. Thus, supplementing with NMN powders or other NAD supplements is often the safest and most convenient way to promote the increased production of NAD. After we know NAD+ and how it works, I guess that you must know why we need take NMN powder? How does it works when NMN powder into our body. In a easy way, NMN is the precursor of NAD+ 4

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before entering our body. Taking NMN powder can increase NAD+ level and help us beat the speed of aging.

Is NMN Powder Safe Supplements?

Most of the data so far has come from animals, which have not shown any side effects. Long-term mice study also showed no toxicity, serious side effects, or increased mortality rate throughout the 12 month intervention period. As far as we know, A human trial was recently conducted out of Japan. The purpose of the trial was to determine if NMN powder was safe to take. NMN was administered to 10 healthy men. Dosages of 100, 250, and 500 mg NMN were given.

The single oral administrations of NMN did not cause any significant clinical symptoms or changes in main biomarkers like heart rate, blood pressure, oxygen saturation, and body temperature. The trial helps to confirm that, in general, NMN powder is safe and well-tolerated; to that end, the trial can be considered a success. This study also measured sleep quality, and found no differences before and after the NMN consumption.

Due to the limited number of human trials, scientists are continuing to explore the side effects of NMN, striving to obtain more clinical data from human trials, in order to ensure that this new anti-aging product is officially launched.

At the same time, we have to talk about Dr. David Sinclair who is one of the 100 most influential people in the world by Time Magazine, has been taking NMN supplements for years with friends in the aging industry. He shared the experience with us after he take NMN powder for long time. He said: “I always takes 1 gram of NMN every day, along with other supplements including resveratrol, metformin, and aspirin. I have not experienced anything other than stomach upset so far.” He also reminded of that we should keep NMN powder in a cool climate or ideally in a fridge, because NMN degrades to Nicotinamide poison your body when NMN is stored in hot/warm temperatures.

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