SomethingaboutPeptideHexarelinyouneedto know
WhatisHexarelin?
DuetoHexarelinabilitytoincreasesecretionofnaturalGrowthHormone,mostofits effectsaresimilartothoseofsyntheticGH,althoughtoaslightlylesserextent.
Effectsofitsuseinclude:increaseinstrength,thegrowthofnewmusclefibres, increaseinthesizeofalreadyexistingmusclefibres,neuralprotection,joint rejuvenation,protectionandhealing.Also,theGHreceptorsinadipose(fat)tissue allowforpotentialfatreductionwithHexarelinuse.TheincreaseofcirculatingGH throughHexarelinusecauseslevelsofInsulin-LikeGrowthFactor(IGF-1)torisein theliver.IGF-1istheprimecauseofmusclegrowthinresponsetoGHstimulation. ThereisnoappetiteboostwithHexarelinuse(asopposedtoGHRP-6’sextreme
appetiteincrease)duetoitsinabilitytodrasticallyincreaseGhrelinlevelsthatare responsibleforaddedhungerandquickergastricemptying InstudieswhereHexarelinwasinjectedsubcutaneously,GrowthHormone, measuredthroughplasmaconcentrations,increasedsignificantlyandwithinthirty minutesofinjection.GHlevelsdecreasedbacktonormalaroundfourhourspost injection.TheGHincreasehasbeenfoundtobeeffectiveupto2mg/kg,anyfurther increaseindosewasfoundtobeineffectiveincausingaGHresponse.
ResearchshowedthatHexarelin’seffectonGHstimulationtaperedbetweenweeks 4through16.Separatingcyclesby4weeksoffperiods,avoidingthenegative feedbackloopandthenextcycleofHexarelinproducedthesamelevelofresultsas thefirstcycle.
Hexarelin(HexarelinAcetate)isasynthetichexapeptideinthegrowthfactorfamily whichstimulatesthereleaseofgrowthhormone(GH)anddoesnotinterferewiththe body’sabilitytoproduceitsownGH.Structurally,Hexarelin(HexarelinAcetate)is similarinstructuretoGHRP-6butwithouttheappetiteincreasebecauseofits inabilitytodrasticallyincreaseGhrelinlevelswhichisresponsiblefortheincreased appetiteandquickergastricemptyingHexarelinisasyntheticgrowthhormone secretagoguemadefromsixaminoacidsItcontainspowerfulgrowthhormone releasingpropertiesinthehumanbodyHexarelininstudiesoveracertainperiod
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hasshownthatitreducesvisceralfatHexarelin(HexarelinAcetate)likeother GrowthHormoneReleasingPeptidesismosteffectivesynergisticallywhen administeredwithGHRHsuchasSermorelinorModifiedGRF1-29
HowdoesHexarelinwork?
HexarelinfromAASrawissounlikeotherGHRP’savailabletoday.Manyconsider hexarelinasanunderdog.Itisoneofthemanysubstancesthathavenotreceived attentionbecauseitisthoughttolacksomeimportantqualitiesthatexcellent peptidesmusthave.Sufficetosaythathexarelinisapeptidethathasbeenhighly underestimated.Today,however,wewilltellyouwhythisspecificpeptidemustnot bepushedaside.
YoumustknowthathexarelinisnotyourtypicalGHRP.Itsstructureasahexapeptide makesitanexcellentchanneltopromotingtheincreasedreleaseofgrowth hormonesAlthoughitsmodeofactionhasnotbeenfullyunderstoodbyexperts,itis wellknownthatitactsonboththehypothalamicareaandpituitaryglandMore importantly,itistheonepeptidethatisabletoproducethelargestamountsofgrowth hormones
Similartomostpeptides,hexarelinisabletoincreasethereleaseofnaturalgrowth hormones.Moreimportantly,itdoesnotdecreasethenaturalabilityofthebodyto
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releasegrowthhormonesSeveralstudieshavealsoshownthatitincreasesfatloss, strengthenconnectivetissues,improvetheelasticityoftheskinandincreasemitosis, meiosisandbonemineraldensity Studies,however,haveshownthatoncehexarelinisinjectedviathesubcutaneous route,itactivatesthefunctioningofthepituitaryglandthroughapulse.Similarto GHRP-6,ithelpsimprovethecirculationofgrowthhormoneswithinthebody. DespitehavingsimilaritieswithGHRP-6,itactsdifferentlyinsomeways.Forone thing,itdoesnotcauseanyhungerissues.Itistruethathexarelinisabletoincrease growthhormonelevelinthebodyhowever,itisalsoabletodecreases somatostati–oneofthemaincausesofnon-productionofgrowthhormones.This meansthattherewillbeincreasedlevelsofgrowthhormones.
WithitsabilitytoraiseIGF-1andgrowthhormonelevels,itcanworkasanexcellent PCTtoolsforindividualswhoarecyclingoffwithsyntheticIGF-1orothergrowth hormones.Itisalsobestthatusersmustneverunderestimateitspotencyparticularly inincreasinglevelsofprolactinandcortisol.Ithasthestrongestaffinitytoincrease cortisolandprolactincomparedtootheravailableGHRP’s
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ThebenefitsofHexarelin
①LeanMuscleGrowth
Youarenotaloneifyoufeelunhappyaboutyourweightorbodycomposition. However,findingasafeandreliablesupplementforgainingleanmuscleisnot alwayseasy.Therearesomanydrugonthemarketandsomeofthemfeaturemore harmfulsideeffectsthantheconditionit’sattemptingtotreat.
Fortunately,theinitialresearchonHexarelinispromisingandmanystandbehindthe peptideintheweightliftingcommunityHexarelinisknowntostimulatenatural growthhormoneproductionwhichcontributestoleanmusclegrowthThepeptide servesasahighlyselectiveagonistoftheGHSRandInsulin-likeGrowthFactor1 (IGF-1)Italsoactscomparabletoghrelininactivatingthegrowthhormone secretagoguereceptorwhilesuppressinginhibitorslikesomatostatinThosethatuse Hexarelininfitnessandbodybuildingnoticeimpressiveresultsintermsofmuscle andstrengthgains.
②FatBurning&WeightLoss
Buildingleanmuscleisonlypossiblebyfirstremovingunwantedfat.It’sadilemma thatmanyofusstrugglewithwhileattemptingtomaintainhealthyeatingand exercisehabits. Fortunately,Hexareliniscapableofacceleratingweightlossbytargetingcritical
naturalprocessesinthebodyTherapidfatlosseffectcanassistyouinreaching yourweightlossgoalsfasterthaneverMoreimportantly,you’lldosoinafarmore safeandeffectivemannercomparedtootherharmfuldrugsordietprogramsThe combinationoffatburningandleanmusclegainsfromHexarelincanleadtoa completebodyoverhaul
③ImprovesStrengthandFlexibility
Whilereceivingacompletebodymakeoveryoualsoinheritthebenefitsofimproved strengthandflexibility.
Hexarelinisknowntovastlyimprovetendonandligamentstrength.Additionally,the peptideislinkedtoenhancedflexibilityandoveralljointhealth.It’scrucialtofocuson tendons,ligaments,andmusclesasyouagebecausetheyareespeciallyatriskfor injury. Consequently,you’llachievelittleifyouarestuckonthesidelinebecauseofa lingeringinjury.Hexarelinnotonlyenablesyoutorecoverandhitthegymsoonerbut avoidsseriousinjuriesinthefirstplacethankstothegainsinflexibility
④StrongerRecovery&AthleticPerformance
Thereareaddedbenefitstolosingweight,gainingleanmuscle,andimproving overallstrength/flexibility
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Forstarters,you’llrecoverfasterwhichgrantsyoutheopportunitytoreturntothe gymandgetbacktoworkRecoveryisessentialtoweightlossandmusclegains,so findingsupplementsthataidinthatprocessisvital
HexarelinisknowntopromotefasterrecoveryfrominjuriesandtrainingIt’s especiallyresistanttomusculoskeletalinjuriesthathamperprogressinthegym. Moreover,you’llwitnessoverallimprovementsinathleticperformanceasaresult.
⑤ImprovesSleepQuality&OverallWell-Being
AnotherbenefittoHexarelinistestimonialsregardinghowthepeptideimproves overallsleepquality.Theenhancementofphysicalcapabilityalongwiththe traditionalexertionofworkingoutgenerallyleadstopeacefulnights.
And,sincesleepissoessentialtooverallhealth,thepeptidecontributestoa strongersenseofwell-being.Losingweightandgettingstrongerleadstoimproved self-esteemandconfidence.
You’llnotonlysleepbetterbutfeelbetterthankstothepositiveeffectsofHexarelin
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SideeffectsofHexarelin
Thankfully,thereportedsideeffectsofHexarelinareminimal.
Themostcommonsideeffectsincludefeelingsoffatigueorlethargy.It’sduetothe abilityofthegrowthhormonetoalsoincreaseadesireforsleep.However,keeping thedosagelowcaneasilyoffsetthisissue.Excess/highdosagesofHexarelinmay contributetowaterretention.
Anothersideeffectthathasbeenreportedistinglingornumbnessinthehandsor feet
Thosethatexperiencesymptomsshouldlowerthedosageorconsiderremoving fromsupplementationaltogether
It’sbesttospeakwithaphysicianbeforeuseifyoualreadytakeotherprescription medication.
Hexarelinvsotherpeptides
HexarelinvsIpamorelin
Whilethemechanismofactionandprimarybenefitsforbothpeptidesarequite similar,thedifferencearisesinthesecondarybenefitsIpamorelinisprovento
improvebonedensity,whilehexarelinenhancescardiovascularhealth
HexarelinvsGHRP-6
ThesebothpeptidesfunctioninthesamewayHowever,GHRP-6(9)doesn’teasily stimulateotherneuroendocrinepathwayslikehexarelinIntermsofpotency, GHRP-6hasarelativelyshorterhalf-lifetoworkinthebodythanhexarelin.Therefore, hexarelinwinstheraceagainstGHRP-6forsure!
References
[1]SucklingK(2006)."Discontinueddrugsin2005:cardiovasculardrugs".Expert OpiniononInvestigationalDrugs.15(11):1299–308.doi:10.1517/13543784.15.
11.1299.PMID17040192.S2CID21632578。
[2]EzioGhigo(1999).GrowthHormoneSecretagogues:BasicFindingsandClinical Implications.Elsevier.pp.178–.ISBN978-0-444-82933-7.
[3]RahimA,O'NeillPA,ShaletSM(1998)."Growthhormonestatusduring long-termhexarelintherapy"TheJournalofClinicalEndocrinology&Metabolism 83(5):1644–9doi:101210/jcem8354812PMID9589671
[4]GhigoE,ArvatE,GianottiL,ImbimboBP,LenaertsV,DeghenghiR,et al(1994)"Growthhormone-releasingactivityofhexarelin,anewsynthetic
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hexapeptide,afterintravenous,subcutaneous,intranasal,andoral administrationinman"TheJournalofClinicalEndocrinology&Metabolism78
(3):693–8doi:101210/jcem7838126144PMID8126144
[5]Imbimbo,BP;Mant,T;Edwards,M;Amin,D;Dalton,N;Boutignon, F.;Lenaerts,V.;Wďż˝thrich,P.;Deghenghi,R.(1994)."Growth hormone-releasingactivityofhexarelininhumans".EuropeanJournalofClinical Pharmacology.46(5):421–5.doi:10.1007/bf00191904.PMID7957536.
S2CID19573322.
[6]C.R.Ganellin;DavidJ.Triggle(21November1996).Dictionaryof PharmacologicalAgents.CRCPress.pp.617–.ISBN978-0-412-46630-4.
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