(MK-677 Powder) Ibutamoren Powder Usage Tips(1)

www.aasraw.com

(MK-677 Powder) Ibutamoren Powder Usage Tips(1)

(MK-677 Powder) Ibutamoren Powder UsageTips(1)............................................................................ 1 1.What’s (MK-677 Powder) Ibutamoren Powder?...................................................... 2 2.(MK-677 Powder) Ibutamoren Powder Main Benefits............................................ 3 1) Ibutamoren Helps Build Muscles...................................................................... 4 2) Ibutamoren Reduce Muscle Wasting............................................................... 4 3) Ibutamoren Increases Bone Density................................................................ 5 4) Ibutamoren Improves Sleep...............................................................................5 5) Ibutamoren Combats Aging and May Increase Longevity............................5 6) Ibutamoren May Have Nootropic Effects.........................................................6 7) Ibutamoren is Beneficial in Treating Growth Hormone Deficiency..............6 8) Ibutamoren May Help with Wound Healing and Tissue Regeneration.......7 9) Ibutamoren May Help with Hangovers.............................................................7

1

AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com

www.aasraw.com

1.What’s (MK-677 Powder) Ibutamoren Powder?

(MK-677 Powder) Ibutamoren Powder is a drug that may improve longevity, bone density, cognitive ability, strength, and metabolism. It’s being investigated for Alzheimer’s disease, frailty in the elderly, and growth hormone deficiency.

MK-677 is also used by athletes to gain a competitive edge in sports. MK-677 binds to the ghrelin receptor, mimicking the effects of ghrelin. These effects included increased appetite, muscle mass, bone mineral density, angiogenesis, VEGF expression, protection of the heart, and modulation of glucose and energy homeostasis.

Ibutamoren is frequently discussed on online forums for its anabolic muscle-building properties. It is available over the counter and used by those wishing to increase their growth hormone levels.

However, clinical studies of this compound are relatively few. In the text below, we will highlight what is known about ibutamoren so far.

Ibutamoren (also known as ibutamoren mesylate or MK-677), promotes the secretion of the growth hormone (GH) and increases insulin-like growth factor 1 (IGF-1).

Ibutamoren increases growth hormone levels, by mimicking the action of the hormone ghrelin, and binding to one of the ghrelin receptors (GHSR) in the brain. Activated GHSR stimulates growth hormone release from the brain.

GHSR is found in brain regions that control appetite, pleasure, mood, biological rhythms, memory, and cognition. Therefore, we can expect that ibutamoren may also affect these functions. However, so far, clinical studies describe only the effects ibutamoren has on appetite – and as expected, like ghrelin, ibutamoren increases it.

A great thing about ibutamoren is that it increases growth hormone levels with little or no increase in other hormones, such as cortisol. Cortisol suppresses the immune system, reduces wound healing, and impairs learning and memory, and it’s usually not good to have this hormone elevated.

2

AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com

www.aasraw.com

2.(MK-677 Powder) Ibutamoren Powder Main Benefits

The health benefits of MK-677 look promising. Growth hormone declines with aging, and MK-677 has proved in randomized, placebo-controlled trials to reverse this decline 1.

This is a classic approach to longevity research. Figure out what hormones, neurotransmitters or other signals decline with aging. Next, see if restoring levels also reverses the effects of aging.

I first became interested in MK-677 because I was researching the relationship between sleep and growth hormone.

Before I discuss the benefits, side effects, and dosage of (MK-677 Powder) Ibutamoren Powder, let’s back up and discuss growth hormone itself.

3

AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com

www.aasraw.com

1) Ibutamoren Helps Build Muscles Ibutamoren is frequently used as an anabolic substance, to increase lean body mass i.e. create bigger muscles. It is orally active and can be taken once a day.

These are all benefits compared with other growth hormone stimulators.

As previously mentioned, ibutamoren increases growth hormone levels and IGF-1. Both growth hormone and IGF-1, in turn, increase muscle mass, muscle strength, and reduce body fat.

In healthy obese men, a two-month treatment with ibutamoren increased lean mass, and transiently increased basal metabolic rate (BMR).

2) Ibutamoren Reduce Muscle Wasting In food-deprived healthy volunteers, ibutamoren reversed diet-induced protein loss, that could cause muscle wasting.

In elderly patients with hip fracture, ibutamoren improved gait speed, muscle strength and reduced the number of falls.

4

AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com

www.aasraw.com

3) Ibutamoren Increases Bone Density Growth hormone (GH) increases bone turnover and eventually bone density.

However, because of the increased turnover in subjects treated with growth hormone, bone density can initially decrease before increasing. Basically, it takes time (> 1 year) to see the bone density increase.

In healthy obese male volunteers, ibutamoren increased bone turnover.

In elderly adults, ibutamoren increased bone building, as measured by osteocalcin, a marker of bone turnover.

In post-menopausal women, ibutamoren increased bone mineral density, which helps increase bone strength and prevent osteoporosis.

4) Ibutamoren Improves Sleep A study showed that in both younger and elderly subjects, ibutamoren improved sleep quality and REM (rapid eye movement) sleep duration.

Apart from scientific studies, there have been many reports of subjective improvements in sleep quality, across various online forums.

5) Ibutamoren Combats Aging and May Increase Longevity Growth Hormone (GH) secretion and muscle mass both decline from mid-puberty throughout life.

In a study in the elderly, daily ibutamoren increased GH and IGF-1 levels to those of healthy young adults without serious adverse effects. IGF-1 is known to have beneficial effects on longevity.

5

AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com

www.aasraw.com

In another study, ibutamoren rejuvenated the growth hormone profile in obese subjects.

6) Ibutamoren May Have Nootropic Effects Some people use ibutamoren as a nootropic because it acts on the ghrelin receptor, which has nootropic effects. You can read more about these effects in the post on ghrelin. Science is, however, yet to study if and how ibutamoren affects cognitive performance.

Two indirect mechanisms by which ibutamoren can improve brain function: Ibutamoren increases IGF-1, which is known to improve memory and learning.

Ibutamoren also increases REM sleep duration and sleep quality. And we know that sleep is essential for good cognitive function.

A study questioned the association of low IGF-1 and Alzheimer’s disease, and whether ibutamoren could be of help. However, in this study, ibutamoren was ineffective at slowing the progression of Alzheimer’s in humans.

7) Ibutamoren is Beneficial in Treating Growth Hormone Deficiency Ibutamoren can increase growth hormone, IGF-1, and IGFBP-3 levels in children with growth hormone deficiency. Furthermore, these effects are achieved without changing the concentrations of prolactin, glucose, triiodothyronine (T3), thyroxine (T4), thyrotropin, cortisol or insulin.

In severely GH-deficient men, ibutamoren increased IGF-1 and growth hormone, with no significant changes in cortisol, PRL, and thyroid hormone levels. However, insulin and glucose were increased.

6

AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com

www.aasraw.com

8) Ibutamoren May Help with Wound Healing and Tissue Regeneration Growth hormone increases tissue regeneration and wound healing, so ibutamoren may help with these.

There are individual reports of ibutamoren being helpful, but scientific studies are lacking.

9) Ibutamoren May Help with Hangovers This one is anecdotal, but people report curing hangovers with ibutamoren.

7

AASraw Biochemical Technology Co.,Ltd aas14@aasraw.com