20 most important things You need to know about Lorcaserin HCL powder(1)

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20 most important things You need to know about Lorcaserin HCL powder(1)

20 most important thingsYou need to know about Lorcaserin HCLpowder(1)......................................... 1 I.Raw Lorcaserin HCL powder basic Characters:.......................................................2 1.What is Lorcaserin hydrochloride powder?............................................................. 2 2. Lorcaserin HCL powder（Belviq）.......................................................................... 3 3. Who can take Lorcaserin HCL powder ( Belviq)?.................................................. 4 4. Who should not take Lorcaserin HCL powder?...................................................... 4 5. How does Lorcaserin hydrochloride powder works?............................................. 5 (1) Mechanism of action — Lorcaserin hydrochloride powder......................... 5 (2) Lorcaserin hydrochloride • Pharmacokinetics:.............................................. 6 (3) Lorcaserin hydrochloride powder works on Obesity.................................... 6

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I.Raw Lorcaserin HCL powder basic Characters:

Name:

Lorcaserin hydrochloride powder

CAS:

1431697-94-7

Molecular Formula: C11H15Cl2N Molecular Weight:

232.1525

Melt Point:

212°C

Storage Temp:

-20℃

Color:

White powder

1.What is Lorcaserin hydrochloride powder?

Lorcaserin hydrochloride powder affects chemical signals in the brain that control appetite. Lorcaserin hydrochloride powder works by helping you feel full with smaller meals. Lorcaserin hydrochloride powder is used together with diet and exercise to treat obesity. Lorcaserin hydrochloride powder is sometimes used to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure. Lorcaserin hydrochloride powder will not treat any underlying health condition (such as heart disease, diabetes, high blood pressure). Keep taking any other medications your doctor has prescribed to treat these conditions.Lorcaserin hydrochloride powder may also be used for purposes not listed in this medication guide.

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2. Lorcaserin HCL powderďźˆBelviq

Lorcaserin HCL powder, brand name:Belviq, main ingredients:Lorcaserin HCL powder, which is used along with diet and bodybuilding to treat obesity,for fat loss.The medicine is sometimes given to treat obesity associated with high cholesterol, high blood pressure, or type 2 diabetes.drug lorcaserin is in a class of drugs known as serotonin receptor agonists. lorcaserin powder works by targeting chemicals in the brain that affect appetite.

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3. Who can take Lorcaserin HCL powder ( Belviq)?

The FDA approved the medication for people who are obese (with a body mass index, or BMI, of 30 or higher) or who are overweight (with a BMI of 27 or above) and also have at least one weight-related health condition such as Type 2 diabetes, high blood pressure or high cholesterol.

4. Who should not take Lorcaserin HCL powder?

• Lorcaserin HCL powder may be execrated in mothers’ milk, therefore it is recommended to discontinue its use or not start therapy while nursing.

• Patients who have serotonin syndrome or neuroleptic malignant syndrome.

• Patients who have defected heart valve(s).

• Patients suffering from severe depression.

• Patients on anti-diabetic medications or those who experience sudden low blood sugar episodes due to anti-diabetic medications.

• Patients who experience priapism, an extended erection in their penis lasting more than 4 hours, must discontinue the use of Lorcaserin HCL powder.

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5. How does Lorcaserin hydrochloride powder works?

(1) Mechanism of action — Lorcaserin hydrochloride powder The Lorcaserin hydrochloride powder works by controlling appetite — specifically by activating brain receptors for serotonin, a neurotransmitter that triggers feelings of satiety and satisfaction. Intake of food is controlled by satiety center, located in ventromedial nucleus of hypothalamus and hunger center present in lateral hypothalamus.Various inputs from higher centers and gastrointestinal tracts converge in arcuate nucleus, where two types of neurons controlling food intake is present. Firstly, food intake stimulatory group producing agouti-related protein and neuropeptide Y; and secondly, food intake inhibitory group containing cocaine and amphetamine regulated transcript (CART) and pro-opiomelanocortin (POMC) neurons. POMC contains 5-HT 2C receptors, which when activated releases alpha-melanocyte-stimulating hormone (alfa-MSH).Both inhibitory and stimulatory neurons further projects paraventricular nucleus in the hypothalamus.Paraventricular nucleus contains melanocyte 4 receptors (MC4R) that inhibits appetiteIn therapeutic doses lorcaserin acts as a selective 5-HT 2C agonist on POMC neurons, which in turn causes release of alfa MSH. 5

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Further alfa MSH acts on MC4R in paraventricular nucleus in the hypothalamus, leading to decrease in appetite. In supratherapeutic doses, lorcaserin also acts on 5-HT 2B and 5-HT 2A receptors.

(2) Lorcaserin hydrochloride • Pharmacokinetics: Lorcaserin hydrochloride is rapidly absorbed in gastrointestinal tract and is delayed with fatty meals. Peak plasma concentration is achieved in 1.5-2 h, with half-life of 11h. It is evenly distributed in cerebrospinal fluid and central nervous system. Lorcaserin hydrochloride is 70% plasma protein bound and metabolized in liver, with major metabolite being lorcaserin hydrochloride sulfamate, and its excretion is mainly through urine (92%) and minor excretion through faces.

(3) Lorcaserin hydrochloride powder works on Obesity The lorcaserin hydrochloride works by controlling appetite — specifically by activating brain receptors for serotonin, a neurotransmitter that triggers feelings of satiety and satisfaction. Serotonin is also involved in mood; many antidepressant drugs work by preventing the reuptake of serotonin and keeping brain receptors bathed in the chemical. Researchers at Arena say their drug is designed to seek out only the serotonin receptors that affect appetite.

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