Chiral chemicals Market report by 78398

CHIRAL CHEMICALS MARKET SIZE Scope of the Study Chiral Chemicals report covers the methods of preparation and separation of chiral substances and the various Applications of Chiral Chemicals in the market. The Methods of preparation and separation of chiral chemicals include Traditional, Asymmetric, Biological and Other methods (such as Membrane Separation Methods, Chiral Discriminators etc). Traditional methods include Diastereomeric Crystallization, Chromatography and Chiral Pool. Asymmetric methods include Synthesis and Catalysis. Biological methods include Bio-catalysis and Kinetic Resolution. The Application areas covered include Pharmaceutical, Agrochemical, Flavors/Fragrances and Other Applications (such as Chromatography, Synthons etc). The report provides an in depth analysis of each of the methods and application areas by their respective categories. The study includes estimates and projections for the total global Chiral Technology market and also key regional markets that include North America, Europe, Asia-Pacific, Japan and Rest of World. Estimates and projections are illustrated graphically. Business profiles of 41 major companies are discussed in the report. The report serves as a guide to global Chiral Chemical industry, as it covers more than 400 companies that are engaged in Chiral Chemical R&D, discovery, testing and supply of products and services. Major Contract Research Organizations serving Chiral Chemical industry are also covered in the Corporate Directory section of this report. Information related to recent product releases, product developments, partnerships, collaborations, and mergers and acquisitions is also covered in the report. Chiral Chemicals report is an ideal research tool providing strategic business intelligence to the corporate sector. This report may help strategists, investors, laboratories, pharmaceutical companies, contract research organizations, biotechnology companies and drug approval authorities in - Gauging Competitive Intelligence  Identifying Key Growth Areas and Opportunities  Understanding Geographic Relevance to Product  Knowing Regional Market Sizes and Growth Opportunities and Restraints  Keeping Tab on Emerging Technologies  Equity Analysis  Tapping New Markets

Analytics and Data Presented in this Report Pertain to Several Parameters Such as –  Global And Regional Market Sizes, Market Shares, Market Trends  Product (Global And Regional) Market Sizes, Market Shares, Market Trends  Technology Trends  Corporate Intelligence  Key Companies By Sales, Brands, Products  Consumer Behavioral Patterns

RITMIR009: Chiral Chemicals – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com

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 Other Strategic Business Affecting Data

Research Methodology RI Technologies publishes business intelligence reports by going through a cycle of diligent research and analysis activity. Research is done using both online and offline resources. The study outline of this report is sketched on the following lines – global market analysis, regional market analysis, product segmentation, global and regional market analysis by product segment, market trends, M&A, R&D, competitive landscape, technology trends, and other key drivers. Current data helps in analyzing the future of the industry and is also helpful for doing market evaluations, and estimating the market size for the future.

This report is uniquely researched and the methodology includes:  Need and Scope of Study  Product Definitions  Segmental Analysis  Regional Analysis  Exclusive Data Analytics  Corporate Intelligence  Feedback

Right from concept to final compilation of this report, both primary and secondary research methods are applied. We have provided exclusive feedback forms/pre-release questionnaires for this report to use the information for authentication of our own findings. Secondary research includes government publications, investment research reports, web based surveys, website information of both companies and markets, and other offline resources such as print publications and CDs. Our compilation of easy to navigate PDF reports is essential value addition resources for leading and growing companies.

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II. REPORT SYNOPSIS

Chiral Chemicals In Greek, the word “chiral” means ‘similar to hand.’ Therefore, these words have been selected to express the inability of an object to superimpose itself on its reflection. The concept can be explained more clearly with an example like the human hands. Left hand is a mirror image of the right hand, and the right hand is a mirror image of left hand. If one palm is superimposed with the other, thumb of one hand would be lying under the little finger of the hand on top, and little finger of the hand on bottom would be lying under the thumb of hand on top. Even the index finger of one hand will not be below the index finger of the other hand. So the hands are said to exhibit chirality. It is difficult to imagine any axis of rotation that would bring about perfect superimposition in the case of human hands. Absence of such improper rotation axis that facilitates superimposition makes the hands or any object, chiral. By converse logic, objects that have a mirror plane or an inversion center, which allows improper rotation axis to operate in such a manner that it is possible to superimpose one half with the other, are not chiral. Symmetrical structures are divisible into equal parts, which have exactly corresponding features, like the left thumb for right thumb, left index finger for right index finger, and so on in human hands. It is the improper rotation axis; however, that determines the chiral characteristics in these structures. Improper rotation facilitates superimposibility by rotating the object 360 degrees on an axis perpendicular to its reflection. If the object is not superimposable after such rotation, then it is chiral. Like objects, molecules with right and left hand structures, also exhibit chirality. Chiral Chemicals have two forms, which are mirror images of one another. Collectively, these forms are referred to as enantiomers. Each molecule forming the enantiomeric pair is an optical isomer of the other. A molecule is said to be an optical isomer of another, when it has same chemical composition as the other but there is no scope for superimposing one on the other. Therefore, enantiomers are stereoisomers, i.e., they are identical twins as far as chemical composition is concerned, but they can be differentiated easily because of spatial orientation of the molecules in them. Optical isomers are used in many applications of all branches of chemistry, biochemistry and pharmacology. They are formed when a molecule has some asymmetric center. Take for example the carbon compounds. Carbon can bond with four different groups because it has a valency of four. If it does bond in such a manner, each such group becomes a stereocenter. In other words, each group bonding to carbon can have a mirror image in another molecule. Therefore, the number of enantiomers is directly proportionate to the number of groups attached to carbon. When a molecule contains more than one carbon, then the number of groups attached to each one of them increases the probability of stereocenters. Some of these stereocenters may or may not invert.

RITMIR009: Chiral Chemicals – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com

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Therefore, they generate permutations and combinations of images that are not mirror images, and are also not superimposable. Such molecules are known as diastereomers. Diastereomers cannot be called enantiomers. Each molecule forming the diastereomeric pair has same chemical composition, but these molecules differ in spatial orientation of one or more of the compounds attached to the asymmetry sources, which are the carbon atoms in our example.

Segmentation of Chiral Chemicals Exhibit 1. Segmentation of Global Chiral Chemicals Market by Method of Preparation/ Separation Method of Preparation/Separation

Application

Traditional

Pharmaceutical

Asymmetric

Agrochemical

Biological

Flavors/Fragrances

Other (1)

Other (2)

(1) Other includes Membrane Separation Methods (2) Other includes Chromatography © RIT, 2013

Exhibit 2. Segmentation of Fields in Method of Preparation/Separation Traditional

Asymmetric

Biological

Diastereomeric Crystallization

Synthesis

Bio-catalysis

Chromatography

Catalysis

Kinetic Resolution

Chiral Pool

RITMIR009: Chiral Chemicals – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com

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Chiral Chemicals – Global Market Analysis Global Chiral Chemicals market is projected to reach about US$ XX.XX billion by 2020 from an estimated US$ XX.XX billion in 2012, growing at a compounded annual growth rate (CAGR) of XX.XX % during the analysis period 2005-2020. Exhibit 3. Chiral Chemicals – Global Value Market Estimations and Predictions (2005-2020) in US$ Billion Year

Value

2005

XX.XX

2006

XX.XX

2007

XX.XX

2008

XX.XX

2009

XX.XX

2010

XX.XX

2011

XX.XX

2012

XX.XX

2013

XX.XX

2014

XX.XX

2015

XX.XX

2016

XX.XX

2017

XX.XX

2018

XX.XX

2019

XX.XX

2020

XX.XX

CAGR %

XX.XX

US$ Billion

2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020

RITMIR009: Chiral Chemicals – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com

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Analysis by Application Global market for Pharmaceutical Application of Chiral Chemicals is the highest with a market share of about XX.XX % throughout the analysis period (2005-2020) and is projected to reach US$ XX.XX billion by 2020 from an estimated US$ XX.XX billion in 2012, registering a CAGR of XX.XX % during the analysis period 2005-2020. Agrochemical Application is projected to have the highest CAGR of almost XX.XX% and the second largest market value of US$ XX.XX billion in 2020. Flavors/Fragrances are projected to have the second fastest CAGR of XX.XX %. Exhibit 4. Chiral Chemicals by Application – Global Value Market Estimations and Predictions (2005-2020) in US$ Billion for Pharmaceutical, Agrochemical, Flavors/Fragrances and Other Year/Application

Pharmaceutical

Agrochemical

Flavors/Fragrances

Other

Total

2005

XX.XX

2006

XX.XX

2007

XX.XX

2008

XX.XX

2009

XX.XX

2010

XX.XX

2011

XX.XX

2012

XX.XX

2013

XX.XX

2014

XX.XX

2015

XX.XX

2016

XX.XX

2017

XX.XX

2018

XX.XX

2019

XX.XX

2020

XX.XX

CAGR%

XX.XX

US$ Billion

2005

2006

2007

2008

2009

Pharmaceutical

2010

2011

2012

Agrochemical

2013

2014

2015

2016

2017

Flavors/Fragrances

RITMIR009: Chiral Chemicals – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com

2018

2019

2020

Other

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Exhibit 5. List of Major Global Companies S. No

Company

Country

Albemarle Corporation

USA

Alps Pharmaceutical Ind. Co., Ltd.

Japan

Altus Pharmaceuticals, Inc.

USA

Anhui Biochem United Pharmaceutical Co., Ltd.

China

Avecia Biologics Limited

BASF Aktiengesellschaft

Germany

More…. © RIT, 2013

Market Overview Chiral technology has made tremendous progress so much so that it can now be developed with ease. This has been made easier with the increase in chiral analytical techniques that are capable of differentiating between enantiomers either during development of the drug or while monitoring its results in the body. Despite the fact that chiral drugs have been in use much before the arrival of modern medicine, it is only now that chiral drugs in the pharmaceutical industry has gained so much attention. This is largely due to the understanding that enantiomers often show different bioactivity and metabolic fates. In addition there is also a commercial reason where pharmaceutical companies have the chance to extend patent coverage after expiry of patents on racemic drugs. This can take place through the development of the chiral switch enantiomers with suitable bioactivity. The usual protocol on drug design and development involves making the isomer mixtures first after which the preferred isomer is selected. Recently there have been many developments in medicinal chemistry that makes use of automated rapid synthesis. This is based on connecting building blocks in a particular manner and this is combined with automated bioscreening for therapeutic activity and selectivity determination. Information gathered must be exact to validate the use of single isomers.

RITMIR009: Chiral Chemicals – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com

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Global Market Analysis Global Chiral Chemicals market is projected to reach about US$ XX.XX billion by 2020 from an estimated US$ XX.XX billion in 2012, growing at a compounded annual growth rate (CAGR) of XX.XX % during the analysis period 2005-2020. North America is expected to have the highest market value of US$ XX.XX billion in 2012 with a market share of XX.XX %. Europe is the second largest market with a market value of US$ XX.XX billion in 2020. Japan is the fastest growing market with a CAGR of XX.XX % and is closely followed by Asia-Pacific with a CAGR of XX.XX %. Exhibit 6. Chiral Chemicals – Global Market Estimations & Predictions (2005-2020) by Geographic Region for North America, Europe, Asia-Pacific, Japan and Rest of World in US$ Million Year /Region

North American

Europe

Asia-Pacific

Japan

Rest of World

Total

2005

XX.XX

2006

XX.XX

2007

XX.XX

2008 2009

XX.XX XX.XX

2010 2011

XX.XX XX.XX

2012

XX.XX

2013 2014

XX.XX XX.XX

2015 2016

XX.XX XX.XX

2017 2018

XX.XX XX.XX

2019 2020

XX.XX XX.XX

CAGR%

XX.XX

US$ Million

2005

2006

2007

2008

North American

2009

2010 Europe

2011

2012

2013

Asia-Pacific

2014

2015

2016

2017

Japan

2018

2019

2020

Rest of World

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CHIRAL CHEMICALS â&#x20AC;&#x201C; THE OUTLOOK Global Chiral Chemicals market is expected to grow at XX.XX% compounded annually from 2005 through 2020. The United States is the leading market for Chiral Chemicals with a market share of more than XX.XX % globally in 2009. The United States is projected to maintain the leading position throughout the analysis period with a drop in its share upto XX.XX % by the end of the analysis period (2020). Due to the cost advantage and access to the latest technology, Asia-Pacific and Japan are the fastest growing markets for Chiral Chemicals with a compounded annual growth of XX.XX % and XX.XX % respectively. Today synthetic and chiral drugs are commercially available. However, many of these chiral drugs are racemic mixtures. It is important for a chiral drug to be present in a pure therapeutically active form so as to avoid the possibility of any untoward effects. Therefore there is an urgency to develop a suitable technology for the analysis and separation of racemic drugs. The most important use of chiral technology is in its application in chiral drugs. Usually the most therapeutically effective form of a drug is the single enantiomer. The pharmacological activity of combined enantiomers has a positive effect thereby making the drugs more effective as racemates. However, there are some drugs where the desired enantiomer is converted into another one by the body thereby making the use of only one enantiomer a drawback. The process by which a drug is metabolized by the body is an important factor that not only defines the fate of a drug but its effect on the body as well. A large part of bioorganic molecules are found to be chiral. This is the reason why researchers are keen to study the separation of chiral compounds. Chiral technology and the progress that has been made on this front have had a positive effect on the pharmaceutical industry with regard to the research and manufacture of drugs. Chiral technology now plays an important role in normal drug design by helping in not just the formation but also the discovery of new receptor-based as well as enzyme-inhibiting small molecule drugs. This is seen especially in drugs that require high selectivity of action. The availability of many new technologies in abundance instead of single-enantiomer chiral drugs makes this technology more acceptable. However, due to the emergence of highly sophisticated and complex mechanisms of synthesis and separation of Chiral Chemicals a number of small, high technology companies have provided a niche for themselves which are primarily for contract or outsource manufacturing. These companies aid large corporations to develop chiral drugs based on their particular products. Major companies such as Avecia, UK, and Dow Chemical's Chirotech Technology Ltd., in the United States strive to maintain broad portfolios of chiral chemicals and technologies. BASF AG (Germany) is one of the leading Chiral companies globally with a varied pipeline of chiral products including Chiral Flavors and Fragrances. Daicel Chemical Industries in Japan is another leading company in Asia-Pacific which provides Chiral stationary phases and Columns for use in Chromatography and also Chiral enzymes.

RITMIR009: Chiral Chemicals â&#x20AC;&#x201C; A Market Insight Report, July 2013 ÂŠ RI Technologies - www.researchimpact.com

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IV. PRODUCT TECHNOLOGY/RESEARCH Definition and Overview of Chiralty An object that possesses a mirror image different from itself is termed as chiral. The unique feature of chiral molecule is that it forms a pair of isomers, which are mirror images of each other. The basic distinction between Chiral and achiral molecules can only be understood by analyzing the symmetry of their molecules. In case there are two sets of molecule that are attached to the same central carbon atom, the molecule is considered to possess a plane of symmetry. If the molecule is cut and the left-hand side is an exact reflection of the right-hand side it is termed as achiral. In case the group contains four molecules then there is no definite symmetry anywhere in the molecule. The molecule, which does not have a definite plane of symmetry, is termed as chiral. The carbon atom that contains four different groups attached is responsible for the lack of symmetry and this is termed as a chiral centre or an asymmetric carbon atom. The molecule that is attached to two carbon atoms and forms a plane of symmetry is called achiral. The chiral molecules only exhibit isomerism.

Concept of Chiral Technology The molecule is termed as chiral if it shows some variation from its mirror image and on the contrary if it does not exhibit any variation from its mirror image it is simply called “achiral”. The alphabets ‘D’ and ‘L’ are used as prefixes to make out which molecular hand is being represented. The alphabet ‘D’ indicates the right and ‘L’ is an indicator of left. Same chemical is used in both of its construction. It is important too clearly demark the different forms as it results in chemical reactions. Thus the technology that is applied to differentiate between the to forms is called Chiral technology

Prominent Principles Governing Chiral Technology The Chiral HPLC columns are formed by the process of immobilizing single enantiomers into the stationary phase. The Resolution completely depends on the formation of transient diastereoisomers onto the outer surface of the column packing. The formation of stable diastereoisomer is directly proportional to the one retained, the stable is the most retained and on the contrary the unstable will be the one to be eluted first. In order to demark between enantiomers there is a requirement of minimum of three points of interaction and this would aid in chiral identification. The forces that accomplish this lead interaction are considered very weak and they require cautious optimization by regulation of the mobile phase and the temperature to exploit selectivity. Chromatography is a multi-step technique employed for separation and it is accomplished by carrying out large number of interactions. But an excellent resolution can only be achieved by a free energy of interaction difference between the enantiomers and the stationary phase.

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The various intermolecular forces that are responsible for chiral identification are pi-pi interactions, polar/ionic interactions, hydrogen bonding and hydrophobic effects. The intermolecular forces can be enhanced using the formation of inclusion complexes and binding them to particular sites like peptide or receptor in complex phases. An expert in the field can easily analyze these intermolecular forces by selecting apt mobile phases. The best example to suit this statement would be the way polar interactions are controlled by the pH. Exhibit 7. Major Drugs, Companies and Sales in the Chiral Pharmaceutical Industry Drug

Generic Name

Major Company

Indication

Sales in US$ Millions

Approved Year

Celexa

Citalopram

H.Lundbeck A/S / Forest Laboratories

Depression

$28.4 (2006)

1998

Lexapro

Escitalopram Oxalate

H.Lundbeck A/S / Forest Laboratories

Depression and Anxiety

$2,105.9

2002

Prilosec

Omeprazole

Astra Merck

Heartburn

$174.6 (2006)

Nexium

Esomeprazole Magnesium

AstraZeneca

Duodenal ulcer disease, erosive esophagitis ,

$6700 (2006)

(2006) 1998 2001

Heartburn and Gastroesophageal Reflux Disease (GERD) Ditropan

Oxybutynin Chloride

Alza Corporation

Overactive bladder

$244.6 (2006)

1999

Norvasc

Amlodipine Besylate

Pfizer

Hypertension and angina

$2,149 (2006)

1992

Rhinocort Aqua

Budesonide

AstraZeneca

Seasonal or Perennial Allergic Rhinitis

$254.7 (2006)

1999

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Knowing Regional Market Sizes and Growth Opportunities and Restraints

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

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Equity Analysis

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Tapping New Markets

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