Apoptosis Market report by 78398

APOPTOSIS MARKET SIZE Scope of the Study This report gives an insight into Apoptosis Mechanism, by Molecular Pathways – Caspase Activators and Inhibitors, Protease/Proteasome Inhibitors, Bcl-2 Modulators and p53 Modulators. The study also focuses on major diseases for which the treatment is based on apoptosis comprising Cancer, Neurodegenerative Diseases, Cardiovascular Diseases and other apoptosis based diseases including HIV infection, Organ Transplant Rejection and MODS. The study provides global market analysis for apoptosis related therapeutic products by the above apoptosis molecular pathways and also by the disease areas. The study includes estimates and projections for the total global apoptosis related therapeutic products market. Projections and estimates are also graphically illustrated by geographic regions encompassing United States, Europe, Japan and Rest of World. Business profiles of 59 major companies are discussed in the report. The report serves as a guide to global apoptosis market, as it covers more than 290 companies that are engaged in apoptosis research, testing and supply of products and services. Major Contract Research Organizations and Universities serving apoptosis market are also covered in the Corporate Directory section of this report. Information related product developments, partnerships, collaborations, and mergers and acquisitions are also covered in the report. Apoptosis Mechanism report is an ideal research tool providing strategic business intelligence to the corporate sector. This report may help strategists, investors, laboratories, pharmaceutical companies, contract research organizations, biotechnology companies and drug approval authorities in- Gauging Competitive Intelligence  Identifying Key Growth Areas and Opportunities  Understanding Geographic Relevance to Product  Knowing Regional Market Sizes and Growth Opportunities and Restraints  Keeping Tab on Emerging Technologies  Equity Analysis  Tapping New Markets

Analytics and data presented in this report pertain to several parameters such as –  Global And Regional Market Sizes, Market Shares, Market Trends  Product (Global And Regional) Market Sizes, Market Shares, Market Trends  Technology Trends  Corporate Intelligence  Key Companies By Sales, Brands, Products  Consumer Behavioral Patterns

RITMIR008: Apoptosis – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com

Sample Page - 1

 Other Strategic Business Affecting Data

Research Methodology RI Technologies publishes business intelligence reports by going through a cycle of diligent research and analysis activity. Research is done using both online and offline resources. The study outline of this report is sketched on the following lines – global market analysis, regional market analysis, product segmentation, global and regional market analysis by product segment, market trends, M&A, R&D, competitive landscape, technology trends, and other key drivers. Current data helps in analyzing the future of the industry and is also helpful for doing market evaluations, and estimating the market size for the future.

This report is uniquely researched and the methodology includes:  Need and Scope of Study  Product Definitions  Segmental Analysis  Regional Analysis  Exclusive Data Analytics  Corporate Intelligence  Feedback

Right from concept to final compilation of this report, both primary and secondary research methods are applied. We have provided exclusive feedback forms/pre-release questionnaires for this report to use the information for authentication of our own findings. Secondary research includes government publications, investment research reports, web based surveys, website information of both companies and markets, and other offline resources such as print publications and CDs. Our compilation of easy to navigate PDF reports are essential value addition resources for leading and growing companies.

RITMIR008: Apoptosis – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com

Sample Page - 2

II. REPORT SYNOPSIS FOREWORD Apoptosis Apoptosis is a method of planned life relinquishment by a cell in a multicellular organism. With the defective process of this biological occurrence being recognized in several life threatening diseases, research work in this area has increased dramatically. Apoptosis is considered to play a prominent and pivotal role in growth and homeostasis of metazoans. The enormous research carried out in the past few years in the field of apoptosis has led to the detection of thousands of genes that contribute and rule the phenomenon of execution, initiation, and regulation of apoptosis. The research pattern earlier was more focused on creating a better understanding of genetic and cell biological features. Attention has now shifted towards organized biochemical and structural analysis, which has led to transparency in the study of various phenomena involved in apoptosis process. Sometimes, the phenomenon of apoptosis comes as a boon, especially when a virus invades the body and causes some viral infections. In such conditions apoptosis can prevent an invading virus and deprive it of a safe place to breed. In a similar way, useless cells are wiped out during growth, metamorphosis, and tissue turnover. This systematic phenomenon is termed commonly as programmed cell death or apoptosis. This phenomenon plays a central role in the operation of the immune and nervous systems. Apoptosis also plays a major role in eradicating cancerous cells. This report analyzes global market for the following apoptosis molecular pathways and the therapeutics products for apoptosis based diseases. Synopsis chapter of the report gives the summary of the global market for apoptosis related therapeutic products by apoptosis molecular pathways and by therapeutic areas for each geographic region – the US, Europe, Japan and Rest of World.

Segmentation of Apoptosis Exhibit 1. Segmentation of Global Apoptosis Related Products Market by Molecular Pathways and Therapeutic Areas Molecular Pathways

Therapeutic Areas

Caspases

Cancer

Protease Inhibitors

Neurodegenerative Diseases

Bcl-2 Modulators

Cardiovascular Diseases

p53 Modulators

*Other (2)

*Other (1) (1) Includes TRAIL, IAPs, MLK Inhibitor, Factor 5A, Protein Kinase Pathway Modulators, Lysophosphatidic Acid Acyltransferase, Nicotinic Acetylcholine Receptor Agonist and HSP27

(2) Includes MODS, organ transplant rejection and HIV infection

RITMIR008: Apoptosis – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com

Sample Page - 3

Exhibit 2. Segmentation of Global Apoptosis Market by Imaging/Detection Technologies for Cancer Apoptosis Imaging Technologies (Cancer) Molecular Imaging Flow Cytometry Optical Imaging *Other (3) (3) Includes Fluorescence Microscopy,Ultrasound, etc. © RIT, 2013

Analysis of Apoptosis Related Products by Molecular Pathways Caspases Caspases are considered as the members of cysteine proteases. These are the enzymes containing critical cysteine residues responsible for cleaving other proteins after aspartic acid residue. This process is considered an exception among the regular proteases. The name ‘caspases’ comes from the molecular function of the compound "cysteine-aspartic-acid-proteases”. Caspases are considered a vital requirement to undergo cell apoptosis or rather programmed cell death in enhancement of various stages of adult life. This vital role has earned it the name of “executioner”. The other function of caspases includes maturating of cytokines of immune system. Unsuccessful apoptosis is considered to breed tumor growth and autoimmune disorders. The study of apoptosis and the one that occurs in Ischemia or Alzheimer’s disease is the center of research these days. These researches have identified the prominence of caspases. Caspases are broadly classified into – Initiator Caspases and Effector Caspases Global caspase activators and inhibitors market is projected to reach US$XX.XX billion by 2020 from an estimated US$ XX.XX billion in 2012, registering a CAGR of XX.XX % during the analysis period 2005-2020. The United States caspase activators and inhibitors market was estimated at US$ XX.XX million in 2012 and is projected to reach about US$ XX.XX billion in 2020. Growing at a CAGR of XX.XX % during the period 2005-2020, the US is further projected to retain the leading position. The US also represents the fastest growing market during the same analysis period. Europe represents the second largest market for caspase activators and inhibitors, while Japan represents the second fastest growing market. European market was estimated at US$ XX.XX million in 2012 and is projected to attain the value of US$ XX.XX billion by 2020.

RITMIR008: Apoptosis – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com

Sample Page - 4

Exhibit 3. Caspase Activators and Inhibitors - Global Value Market Estimations & Predictions (2005 -2020) in US$ Million by Geographic Region for United States, Europe, Japan and Rest of World† Year /Region

United States

Europe

Japan

Rest of World

Total

2005

XX.XX

2006

XX.XX

2007

XX.XX

2008

XX.XX

2009

XX.XX

2010

XX.XX

2011

XX.XX

2012

XX.XX

2013

XX.XX

2014

XX.XX

2015

XX.XX

2016

XX.XX

2017

XX.XX

2018

XX.XX

2019

XX.XX

2020

XX.XX

CAGR%

XX.XX

# Represents Western Europe only † Comprises Asia-Pacific (excluding Japan), Eastern Europe, Latin America, Middle East and Africa © RIT Figures, 2013

US$ Million

2005

2006

2007

2008

United States

2009

2010

2011 Europe

2012

2013

2014

2015

2016

Japan

RITMIR008: Apoptosis – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com

2017

2018

2019

2020

Rest of World

Sample Page - 5

REGIONAL MARKET ANALYSIS Europe Growing at a CAGR of XX.XX % for the period 2005 through 2020, European apoptosis related therapeutic products market is projected to reach US$ XX.XX billion by 2020 from an estimated US$ XX.XX billion in 2012. Exhibit 4. Apoptosis Related Products – European Value Market Estimations & Predictions (2005 - 2020) in US$ Million Year

Value

2005

XX.XX

2006

XX.XX

2007

XX.XX

2008

XX.XX

2009

XX.XX

2010

XX.XX

2011

XX.XX

2012

XX.XX

2013

XX.XX

2014

XX.XX

2015

XX.XX

2016

XX.XX

2017

XX.XX

2018

XX.XX

2019

XX.XX

2020

XX.XX

CAGR%

XX.XX

US$ Million

2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020

RITMIR008: Apoptosis – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com

Sample Page - 6

III. MARKET DYNAMICS Market Overview Over the last half a decade, availability of apoptosis related products (drugs, kits and reagents) has increased enormously. The global market for apoptosis related products is growing fast owing to increasing evidence of role of apoptosis in mechanism of action for large number of diseases such as Cancer; Neurodegenerative Diseases including Alzheimer’s, Parkinson’s, Multiple Sclerosis and Rheumatoid Arthritis; Cardiovascular Disease; and other apoptosis based diseases including organ transplant rejection and HIV infection. In terms of application, majority of apoptosis related products find application in various cancers such as breast melanoma, lung and prostate. Neurodegenerative diseases is the second largest end use sector for apoptosis related products followed by cardiovascular diseases. This phenomenon is expected to continue throughout the analysis period 2005-2020.

Global Market Analysis Global market for apoptosis related products is projected to reach about US$ XX.XX billion by 2020 from an estimated US$ XX.XX billion in 2012, growing at a Compounded Annual Growth Rate (CAGR) of XX.XX % during the analysis period, 2005-2020. The United States was estimated as the largest market for apoptosis related products in 2012 with a share of XX.XX %, valued at US$ XX.XX billion (2012), and is projected to reach US$ XX.XX billion by 2020 to retain its position with market share increasing to XX.XX %. The US is also projected to be the fastest growing market with a CAGR of XX.XX %. Europe is projected as the second largest (XX.XX % market share in 2012) market during the same analysis period, while Japan is projected to be the second fastest growing (XX.XX % during 2005-2020) market. In 2012, the market for apoptosis related therapeutic products in Europe and Japan was estimated at US$ XX.XX billion and US$ XX.XX billion respectively Rest of World, Asia-Pacific (excluding Japan), Eastern Europe, Latin America, Africa and Middle East, region’s market for apoptosis related products was estimated at about US$ XX.XX million for 2012.

RITMIR008: Apoptosis – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com

Sample Page - 7

Exhibit 5. Apoptosis Related Products – Global Value Market Estimations & Predictions (2005 - 2020) in US$ Million by Geographic Region for United States, Europe#, Japan and Rest of World† Year /Region

United States

Europe

Japan

Rest of World

Total

2005

XX.XX

2006

XX.XX

2007

XX.XX

2008

XX.XX

2009

XX.XX

2010

XX.XX

2011

XX.XX

2012

XX.XX

2013

XX.XX

2014

XX.XX

2015

XX.XX

2016

XX.XX

2017

XX.XX

2018

XX.XX

2019

XX.XX

2020

XX.XX

CAGR%

XX.XX

# Represents Western Europe only † Comprises Asia-Pacific (excluding Japan), Eastern Europe, Latin America, Middle East and Africa © RIT Figures, 2013

US$ Million

2005

2006

2007

2008

United States

2009

2010

2011 Europe

2012

2013

2014

2015

2016

Japan

RITMIR008: Apoptosis – A Market Insight Report, July 2013 © RI Technologies - www.researchimpact.com

2017

2018

2019

2020

Rest of World

Sample Page - 8

IV. PRODUCT RESEARCH Disease Areas Connected with Apoptosis Diseases requiring apoptosis-based treatments include cancer, neurodegenerative diseases, cardiovascular diseases and other important apoptosis based diseases including organ transplant rejection, HIV infection, and multiple organ dysfunction syndrome (MODS).

Cancer Cancer research has delivered outstanding progress in understanding the biology and genomics of cancer, in the last 5-6 years. Foremost of these progresses is that the recognition of apoptosis and its regulatory genes have an effect on melanoma. In return, other oncogenical changes stimulate apoptosis and override apoptosis during multistage carcinogenesis by making selective pressures. Apoptosis associates cancer therapeutics with cancer genetics by providing conceptual structure, as similar changes that suppress apoptosis during tumor development.

Major Companies in Global Cancer Market In 2010, Roche Group/ Genentech bagged top position for cancer therapeutic products market with XX.XX % of total sales of global top 10 companies. Novartis AG, Sanofi-Aventis and Amgen, Inc. ranked second, third and fourth respectively in the above year. Exhibit 6. Global Market for Cancer Therapeutic Products (2010): Percentage Breakdown of Market Share for Top 10 Companies Company Name

Market Share

Roche Group

XX.XX

Novartis AG

XX.XX

Sanofi-Aventis

XX.XX

Amgen, Inc.

XX.XX

AstraZeneca plc

XX.XX

Eli Lily & Co.

XX.XX

Celgene Corp.

XX.XX

Pfizer, Inc.

XX.XX

Bristol Myers Squibb Co.

XX.XX

Merck & Co.

XX.XX

Total

100.00

Sample Page - 9

Exhibit 7. Sales of Approved Drugs - Apoptosis Inhibitors & Inducers Brand Name

Generic Name

Indication

Sales (2009)

Tarceva

erlotinib hydrochloride Non-Small Cell Lung Cancer

US$1.3 billion

Sutent

sunitinib malate

Advanced renal cell carcinoma and gastrointestinal stromal tumor (GIST) XX.XX

Thalomid

thalidomide

Oncology & Immunomodulators

XX.XX

XXXXX

Human Pancreatic Cancer

XX.XX

XXXXX

Peripheral T-cell lymphoma

XX.XX

XXXXX

B-cell non-Hodgkin lymphoma

XX.XX

XXXXX

Cutaneous t-cell lymphoma

XX.XX

XXXXX

Colon Cancer

XX.XX

XXXXX

CML, GIST Chronic Myelogenous Leukemia, GI Stromal Tumors

XX.XX

XXXXX

Colon Cancer

XX.XX

XXXXX

Cancer

XX.XX

XXXXX

Prostate Cancer

XX.XX

XXXXX

Bone Cancer

XX.XX

XXXXX

Colon Cancer

XX.XX

XXXXX

Breast Cancer

XX.XX

XXXXX

Breast Cancer

XX.XX

APOPTOSIS MOLECULAR PATHWAYS - THE MARKET OUT LOOK Global apoptosis related products market is projected to grow at an unbelievable CAGR XX.XX % during the analysis period 2005 through 2020. This enormous growth is mainly due to the evidence of apoptosis’ pivotal role in the mechanism of action in key disease areas including cancer, neurodegenerative diseases and cardiovascular disorders. The growth is also owing to increasing incidences of neurodegenerative cases in major markets such as the United States and Japan. Intense research and development efforts by pharmaceutical giants such as Roche, Novartis, SanofiAventis, Astra-Zeneca, Johnson & Johnson, Pfizer, Eli-Lilly and Bristol-Myers Squibb, new and innovative apoptosis related products (kinase kits and reagents) and drugs are being introduced into the market. The phenomenon keeps the hopes of apoptosis market growth alive in the years to come. Currently, apoptosis market is experiencing quite a few consolidations such as acquisition of stake in Tanox by Genetech, research partnership between Takeda and XOMA, acquisition of Qiaer Bio by Aida, acquisition of Serologicals by Millipore and acquisition of BioSource by Invitrogen. These amalgamations are expected to create a tough and neck-to-neck competition between major players in the industry. The United States, expected to account for about XX.XX % of global market in 2010, is projected to remain the single largest market for apoptosis related therapeutic products. Japan is also expected to increase its market share from XX.XX % estimated in 2012 to XX.XX % in 2020. As this report covers only key Western European markets such as Germany, the UK and France, the estimated market for Europe represents Western Europe only. Western European market is projected to lose its dominance partially by the end of the review period, due to the emerging markets in Rest of World such as Asia-Pacific countries, Eastern European countries, and Latin American countries. The key upcoming markets in Rest of World region include China, India, Brazil and Eastern European countries.

Sample Page - 10

About RI Technologies RI Technologies is a premier source of market research on the Biotechnology & Healthcare sector. We emphasize on factual insights and forecasts with maximum global coverage. RI Technologies is constantly monitoring the biotechnology & Healthcare industry, tracking market trends, and forecasting industry based on specialized analysis. The life sciences sector is an ever growing marketplace with emerging technologies in areas of discovery, design and development.

Research – As Good as the Methodology is! 

Gauging Competitive Intelligence



Identifying Key Growth Areas and Opportunities



Understanding Geographic Relevance to Product



Knowing Regional Market Sizes and Growth Opportunities and Restraints



Keeping Tab on Emerging Technologies



Equity Analysis



Tapping New Markets

© COPYRIGHT The copyright and publication rights to all RI Technologies' reports and other products are the property of the company. Plagiarism of any kind accounts to violation of copyright laws. Any type of reproduction of the material without express permission is not allowed. The buyer, under no circumstances, shall license, resell or repackage, or sell data without prior permission of the company.

DISCLAIMER RI Technologies sells content in good faith. The company is not liable to the buyer for any implications arising out of the usage of data for any particular purpose. The company makes no representations or warranties for the accuracy or completeness of the data. While extreme caution and effort is practiced for data compilation and presentation, the company does not accept any responsibility for findings in the study which are a cumulative effort of primary and secondary research resources. The studies do not endorse or promote any product or company. RI Technologies, its affiliates, partners, distributors, and contractors are not liable for inaccuracies or incompleteness of the reports. User discretion is recommended for the usage of the data.

Sample Page - 11

Sample Page - 12