Stanford University School of Medicine, Lorry I. Lokey Research Building

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LORRY I. LOKEY STEM CELL RESEARCH BUILDING

STANFORD UNIVERSITY SCHOOL OF MEDICINE

BACKGROUND

The California Institute of Regenerative Medicine (CIRM) was established in November 2004 with the passage of Proposition 71, the California Stem Cell Research and Cures Act, at a time when federal funding for embryonic stem cell research was severely constrained. The statewide ballot measure provided $3 billion in funding to promote stem cell research at California universities and research institutions and required setting up CIRM to oversee allocation of the money.

The Lorry I. Lokey Stem Cell Research Building is the result of a $43.6 million award from CIRM — the largest award to any recipient — as well as a generous gift from Lorry I. Lokey, the founder of Business Wire and a Stanford University alumnus. The remainder of the building’s budget was raised through private donations and University resources. The CIRM funding came with the stipulation that construction of the new building, beginning in 2008, must be completed in two years.

LORRY I. LOKEY STEM CELL RESEARCH BUILDING

STANFORD UNIVERSITY SCHOOL OF MEDICINE

OWNER

Stanford University

LOCATION

Palo Alto, California

DATE COMPLETE

August 2010

ARCHITECT

ZGF Architects LLP

ZGF DESIGN TEAM

PARTNER-IN-CHARGE Joseph Collins

PRINCIPAL DESIGNERS Paul Engels, Toby Hasselgren

PROJECT ARCHITECT Renee Kajimoto

INTERIOR DESIGNER Katy Krider

PROJECT TEAM Owen Turnbull, Curt Williams, Sienna Hill, Jill Asselineau, Kathy Berg, Curtis Pittman

INTEGRATED DESIGN COORDINATOR Craig Briscoe

SPECIFICATIONS WRITER Fred Chomowicz

RENDERINGS Colin McStravick

CONSULTANTS

LABORATORY PLANNER Jacobs Consultancy/GPR Planners Collaborative

MECHANICAL/ELECTRICAL/PLUMBING ENGINEER Gayner Engineers

STRUCTURAL ENGINEER Rutherford & Chekene

CIVIL ENGINEER BKF Engineers

LANDSCAPE ARCHITECT Tom Leader Studio

CURTAIN WALL Walters & Wolf

GRAPHICS/WAYFINDING & PRINT Anderson Krygier, Inc.

LIGHTING Francis Krahe & Associates, Inc.

ACOUSTICS Altermatt Associates

ELEVATORS Lerch Bates Inc.

WIND CONSULTANT Ambient Air Technologies, LLC

CONTRACTOR

The Whiting-Turner Contracting Company

DESIGN OVERVIEW

Taking its cues from both the historical architectural heritage of Stanford’s main campus and the mid-20th century modern vernacular of the Medical Campus, the Lokey Stem Cell Research Building’s architecture reflects the School of Medicine’s desire to create a modern medical research environment. Flexibility, cost effectiveness, and collaboration are hallmarks of the new facility. The building’s exterior, consisting primarily of limestone and glass, provides a prominent and distinctive new entry for the Stem Cell Biology and Regenerative Medicine Institute while creating a strong visual relationship with the existing Clark Center and Li Ka Shing Center for Learning and Knowledge.

The interior glazing of the atrium promotes privacy for stem cell research laboratories within the building while maximizing transparency and integration of indoor and outdoor community space within the footprint of the building and grounds. A large atrium lobby also serves as a pedestrian thoroughfare to other parts of the School of Medicine campus and provides an additional gathering space for the research community.

The project’s program has been directed by user needs, with labs and offices positioned to be as efficient as possible. In a faculty survey the design team discovered that a concept of “integrated neighborhoods” to promote collaboration among researchers was favored. Although large, open labs were desired, more integrated neighborhoods of a more intimate scale were thought to help counter some of the negatives associated with them, such as higher noise levels and lack of privacy.

BUILDING PROGRAM

The Lorry I. Lokey Stem Cell Research Building houses the Stanford Stem Cell Biology and Regenerative Medicine Institute, which is focused on making discoveries in stem cell research and translating them into pre-clinical applications, innovative therapies and treatments. The 204,640 GSF building also integrates the resources of the Stanford Cancer Center and the Stanford Institute for Neuro-Innovation & Translational Neurosciences to promote collaboration and discovery among researchers from multiple disciplines including cancer, neuroscience, cardiovascular medicine, transplantation, immunology, bioengineering and developmental biology. The project is designed to be LEED Silver equivalent and includes research and office space for 33 principal investigators and an underground connection to nearby research facilities.

A number of design features contribute to this neighborhood concept. “Hot spots” intended for collaboration have been strategically located and designed to facilitate interaction amongst researchers. Principal investigator office suites are grouped together in pairs at the edge of each lab zone. The principal investigators’ highest priority was the proximity of their offices to their lab benches to enhance interactions with their research staff and other faculty. Additionally, administration offices are centrally located to coordinate critical programmatic functions.

Each of the three above-grade laboratory floors contains conference rooms that can accommodate various group sizes. While the conference rooms support planned and formal interactions, additional “hot spots” for unplanned, informal interactions are incorporated throughout the building and include open kitchen areas on the second and third floors.

The three above-grade floors are composed of two wings that accommodate five and six laboratories respectively. The basement floor contains the core labs shared by all researchers. To provide space for visiting researchers and benches for shared alternative research typologies, including translational research, 60 community benches are intermixed within the neighborhoods. Internal connections, corridors between labs and common equipment rooms provide additional opportunities for access and collaboration.

SIZE TOTAL 204,640 SF LABORATORIES 114,560 SF LAB SUPPORT 55,320 SF OFFICE 14,700 SF CONFERENCE 5,020 SF

SITE

The site, formerly a surface parking lot, occupies a strategic location in proximity to the Schools of Engineering, Humanities and Sciences — a key factor in promoting and enhancing collaborations among faculty, postdoctoral fellows, and graduate students of many different departments and schools. As the first of three Institute-based buildings, the Lokey Stem Cell Research Building begins to knit together a research precinct, define the southern edge of the Discovery Walk, and frame a new formal entry to Stanford’s School of Medicine. The School of Medicine’s 550 researchers, previously scattered in multiple locations, are now located within a 5-minute walk of 95% of all school of medicine facilities. An entry courtyard at the northeast corner of the building provides public gathering spaces that function as interaction and mixing points for faculty, researchers and visitors, and a “Discovery Walk” that borders the building forms an important pedestrian link between the School of Medicine research buildings and the broader academic community beyond.

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SITE PLAN
1 Lorry I. Lokey Stem Cell Research Building Discovery Walk School of Medicine Entry Courtyard Lorry I. Lokey Stem Cell Research Building Courtyard Center for Clinical Sciences Research Beckman Center for Molecular Biology Li Ka Shing Center for Learning and Knowledge Fairchild Center James H. Clark Center
1 3 5 6 7 2 8 N N 10 4 9
School of Medicine loading dock
ABOVE View from Campus Drive BELOW View from Discovery Walk/Courtyard
PHOTOGRAPHER © Robert Canfield Photography LEFT Entry from “Discovery Walk” RIGHT Three-Story Atrium Entry Lobby PHOTOGRAPHER © Robert Canfield Photography
FIRST FLOOR 1 Computational Labs 2 Wet Labs 3 Lab Support 4 Conference 5 Offices 6 Atrium 7 Main Entry 0' 16' 32' N N 0’ 15’ 30’ 1 4 5 6 2 4 4 5 5 5 5 7 3 3 5 2
SECOND
THIRD FLOOR 1 Administrative 2 Labs 3 Lab Support 4 Conference 5 Offices 6 Atrium 1 3 2 4 5 6 5 5 5 0' 16' 32' N N 0’ 15’ 30’ 3 2 5
/
T
1 Imaging 2 Mechanical 3 Electrical 4 BSL2 Suite 5 Lockers / Lounge 6 Conference 7 Core Labs 8 Holding Suites 9 Behavioral Testing 1 3 4 5 6 7 2 0' 16' 32' N N 0’ 15’ 30’ 8 9 8
LOWER LEVEL

RESEARCH NEIGHBORHOODS

Lab 1/Adjoining Office Suite

Lab 2/Adjoining Office Suite

Lab 3/Adjoining Office Suite

Lab 4/Adjoining Office Suite

Interaction Spaces

First floor plan shows the organization of the “research neighborhoods.” Each lab has its own office suite.

FLEXIBILITY / MODULARITY OF LABS

Laboratory infrastructure was developed to provide for ultimate flexibility over time, whether changing equipment and instrumentation for new faculty needs, or accommodating new research programs and principal investigators. The concept of a modular lab unit serves as the basic building block, with 33 modular lab units in total, each measuring 1,260 SF. Each lab module accommodates 16 benches and 12 desks; four additional desks can be flexibly configured so that up to 16 lab technicians can be accommodated in each lab.

To further maximize flexibility, ZGF adopted a generous 1:1 lab-to-lab support ratio throughout the building. The types of uses for the support space include: tissue culture, microscopy, controlled environment (cold and warm rooms), shared instrument, darkroom, radio isotope, and autoclave. This flexible support space can be changed from instrumentation rooms to tissue culture rooms or other specialized functions as required to support various research activities. It can also be reverted to a generic lab module design if desired. Overall, there is more than 169,000 SF dedicated to research and research support space, with a total of 528 lab benches and 396 lab desks.

Flexibility and modular concepts are also applied to lab furnishings. Benches are moveable with shelving connected to the bench instead of the building. Bench utilities are accessed from the ceiling with “quick connects” for each bench. Bench heights are adjustable to meet individual criteria and ADA requirements. Under-bench casework is on castors to allow interchangeability of types and styles of casework.

The building design clusters laboratories and lab support space together, while administrative and communal space are likewise clustered. The modular layout achieves a 65% net-to-gross ratio, demonstrating a cost effective solution when measured against peer buildings, with overall building efficiency typically measuring between 55% and 60%.

Interaction Space Off Main Connecting Stair

PHOTOGRAPHER © Robert Canfield Photography LEFT Informal “Hotspot” Adjacent to Lab RIGHT More Formal Conference Rooms PHOTOGRAPHER © Robert Canfield Photography Classrooms and Informal Meeting Spaces Adjacent to Connecting Stairs PHOTOGRAPHER © Robert Canfield Photography

ART PROGRAM

Within the building, there is a “marriage of art and science.” According to institute director Irving Weissman, MD, artwork throughout the Lokey Stem Cell Research Building inspires creativity and hope while reminding researchers of the human condition.

The largest installation is the Tre Stelle di Lapislazzuli (Italian for “Three Stars of Lapis Lazuli”) Chandelier by Dale Chihuly, composed of 2,071 pieces of blue glass. The work of art garnishing the atrium, with a length of more than 33 feet, spans three stories and weighs 4,300 pounds. It was commissioned for Stanford by the My Blue Dots Foundation, a nonprofit organization with the purpose of combining art with science to create healing, hope and health.

SUSTAINABLE DESIGN STRATEGIES

Stanford has a long-standing commitment to resource conservation and sustainability. Reflecting that commitment, the Lorry I. Lokey Stem Cell Research Building has been designed to adhere to Stanford’s meticulous Guidelines for Sustainable Buildings and to reflect guidelines set forth by programs such as the U.S. Green Building Council’s Leadership in Energy and Environmental Design (LEED) Rating System. More specifically, following Stanford’s sustainability metrics, the building is designed to exceed LEED Silver benchmarks.

Extensive sustainable-design features have been incorporated into the design of the Lokey Stem Cell Research Building, including:

• Fixed sun shades on the East, West and South facades to reduce solar heat gain

• Distributed heating and cooling system with sophisticated controls

• Clerestory glazing in the atrium and daylight glazing in the labs to increase natural light while reducing the need for electric light use

• Rapidly renewable resources, such as bamboo, incorporated where appropriate

• Reclaimed and local materials used for the project site and building’s interior spaces

• A high-efficiency lighting system utilizing zoned photo sensors and occupancy sensors to reduce the need for artificial lighting

• A reduction in water use through rain water harvesting, bio-swales, drought-tolerant indigenous landscaping and low-flow fixtures/ toilets as well as reclaimed water from Stanford’s Co-Gen Facility used for irrigation and toilet flushing

Due to the air volume needed to maintain a healthy environment, lab buildings use approximately 400% more energy than a standard office building. A recent energy survey of labs at Stanford has measured the Lokey Stem Cell Research Building as the most energy-efficient lab building on campus, primarily due to the mechanical system design.

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