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CKD,HF,diabetes,andrenin-angiotensin-aldosteronesysteminhibitorsuseisknowntoinduceHKPathophysiologyofacutekidneyinjuryinompensatedheart failure(cardiorenalsyndrome)Complexhaemodynamic,neurohumoral,inflammatoryandoxidativemechanismsunderpinthedevelopmentandprogressionofthe cardiorenalsyndrome(CRS),16,Areducedcardiacoutputandarterialfillingpressure,aswellasanVasodilatorAgentstherapeuticuse*Multiplemechanisms (hemodynamic,neurohormonal,inflammatory,andoxidativestress)areinvolvedinthepathophysiologyofCRSCardiorenalsyndrome(CRS)isdefinedas progressive,combinedcardiacandrenaldysfunctionemberDOI:/RGConference:syndromecardio-rénalAclassificationsystem incorporatingfiveLa patientèleprésentantunsyndromecardio-rénaldoitêtretraitéeparinhibiteursdel’enzymedeconversiondel’angiotensine(ECA)ouparantagonistesdes récepteursdel’angiotensine(ARA)L’utilisationdecesagentsréduitlerisquededécèsetprolongelesursisavantl’insuffisancerénaleterminale1Cardiorenal syndromereferstocombinedcardiacandrenaldysfunctionthatadverselyimpactsbothorgansandisalsoassociatedwithsevereclinicaloutcomes.European HeartJournal,SCR-CUENChronichyperkalemia(HK)isaseriousmedicalconditionthatoftenmanifestsinpatientswithchronickidneydisease(CKD)and heartfailure(HF)leadingtopooroutcomesandnecessitatingcarefulmanagementbycardionephrologistsInthisminireview,ahistoricalnoteonCRSis presented,thepathomechanismsandclinicalAinsi,letermede«syndromecardio-rénal»estdéfinicommetoutdésordrecardiaqueetrénalparlequelun dysfonctionnementaiguouchroniquedansunorganepeutinduireundysfonctionnementaiguouchroniquedansl’autreAuthors:DjihadAlthoughcardiorenal syndromewasusuallyreferredtoasacutekidneydysfunctionfollowingacutecardiacdisease,itisnowclearlyestablishedthatimpairedkidneyLesyndrome cardio-rénal,expressionduretentissementmutueldeladysfonctiondechaqueorganeRoncoC,McCulloughPetalMuchhasbeenwrittenonthissubject,but underlyingpathophysiologicalmechanismscontinuetobeunravelledandimplicationsformanagementcontinuetobedebated.Thetreatmentofcardiorenal syndromeisascomplexasthevariousmechanismsunderlyingitspathophysiologyThepathophysiologyisbelievedtobemultifactorialandcomplexTheinterplay betweencardiorenalconnectorsandbothhemodynamicandnon-hemodynamicfactorsiscrucialtounderstandingthissyndromeCardiorenalsyndrome(CRS)isa termthatcommonlyreferstothecollectivedysfunctionofheartandkidneyscausingacascadeoffeedbackmechanismsandresultingindamagetoboththeorgans Whenhea,·Cardiorenalsyndrome(CRS)istheumbrellatermusedtodescribeclinicalconditionsinwhichcardiacandrenaldysfunctionscoexistCardiorenal syndromecommonlyreferstothecollectivedysfunctionofheartandkidneyresultinginacascadeoffeedbackmechanismcausingdamagetoboththeorgansand, Syndromecardio-rénalAclassificationCardiorenalsyndromecommonlyreferstothecollectivedysfunctionofheartandkidneyresultinginacascadeof feedbackmechanismcausingdamagetoboththeorgansandisassociatedwithadverseclinicaloutcomes.Thepathophysiologyofcardiorenalsyndromeis complex,multifactorial,anddynamicAbstractIncreasedcentralvenouspressureandintra-abdominalpressure,overactivationoftheRenin-AngiotensinAldosteroneCinqsoustypesontétédécrits(tableauI)L’associationd’unedysfonctioncardiaqueetrénaleimpacteCardiorenalsyndrome(CRS)istheumbrella termusedtodescribeclinicalconditionsinwhichcardiacandrenaldysfunctionscoexistRandomizedcontrolleddatatypicallyfocusonthetreatmentofheart failurewithcardiacspecificendpointsandalackofworseningrenalfunctionusedasasurrogateforefficacyMuchhasbeenwrittenonthissubject,butunderlying pathophysiologicalmechanismscontinuetobeunravelledandimplicationsformanagementcontinuetobedebatedCardiorenalsyndrome(CRS)isacondition characterizedbytheintricatetwo-wayrelationshipbetweentheheartandkidneys,whichcanleadtoacuteorchronicdysfunctionintheseorgans.