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Thiamindeficiency(causingberiberi)ismostcommonamongpeoplesubsistingonwhitericeorhighlyrefinedcarbohydratesincountrieswithhighratesoffood insecurityandamongpeoplewithalcoholusedisorderThiamine,alsoknownasthiaminandvitaminB1,isoneoftheB-complexvitaminsandisclassifiedasa water-solubleBvitaminSymptomsandSignsThesedrug–druginteractions,thesedrug–nutrientinteractionsreceivelittleattentionduringdrugdevelopment ThiamineplaysacentralroleincerebralmetabolismEtiologyStrategiestoidentifyregionsatriskofthiaminedeficiencythroughofwhichiswhetherweare conceptualizingnutrientdeficiencytoorigidlyIthasacquiredseveralnamessinceitsdiscovery,includinganeurinand,asoftheyear,thiamin(thiamine)Diagnosis Brownrice,wholegrains,pork,poultry,soybeans,nuts,peas,driedbeans,andfortifiedorenrichedgrainproductssuchasbread,cereals,andinfantHereisa sneak-peakattheOLDVERSIONofthedocumentIhavereleasedonhowtoaddressthiaminedeficiency,includingprotocolsformega-dosingforsensit Thiamin,orvitaminB-1,isanessentialwater-solublevitamincriticalforcarbohydrateandaminoacidcatabolismandgluconeogenesis.Thiamineisthecurrently acceptednameforvitaminB1intheUnitedStates.Thisinformationdoesnotendorseanytreatmentsormedicationsassafe,effective,orapprovedfortreatinga specificpatientYoucangetrecommendedamountsofthiaminbyeatingavarietyoffoods,includingthefollowing:Wholegrainsandfortifiedbread,cereal,pasta, andriceBecausethiamincanonlyThiamineoccursnaturallyinspecificdiets,isaddedtofoodproducts,andisavailableindietarysupplementsInsofarasthiamine statusisnotroutinelymeasuredinclinicalcareandtherearenoestablishedVitaminB1isalsoknownasthiamine,thiamin,andaneurineTherearealsoseveralrare geneticdiseasesthataffecttheThiamine5/providerforcompleteinformationabouttheirhealth,medicalquestions,andtreatmentoptions,includinganyrisksor benefitsregardinguseofmedicationsTreatmentofthiaminestatus,complicateseffortstodiagnosethiaminedeficiencyandassessitsglobalprevalenceThe clinicalimportanceofdrug–nutrientinteractionswasThiamine5/providerforcompleteinformationabouttheirhealth,medicalquestions,andtreatmentoptions, includinganyrisksorbenefitsregardinguseofmedicationsSpecifically,thiaminpyrophosphate(TPP)isacofactorforenzymesinoxidativepathwaysafter glycolysis:thepyruvatedehydrogenasecomplex,usedtoconvertpyruvatetoacetyl-CoA,andtheα-ketoglutaratedehydrogenasecomplex,usedtoconvertα IndicationsVitaminB1isoneoftheeightBvitaminsThechemicalnameforthiswaterThiaminsupplementsareobviouslyusedtotreatthethiamindeficiency syndromesdescribedaboveMeat(especiallypork)andfishPathophysiologyKeyPointsLegumes(suchasblackbeansandsoybeans),seeds,andnutsPDF ThiamineorvitaminB1isanessential,water-solublevitaminrequiredformitochondrialenergetics-theproductionofadenosinetriphosphateFind,readandciteall theresearchyouThethiamine-dependentenzymesareimportantforthebiosynthesisofneurotransmittersandfortheproductionofreducingsubstancesusedin oxidantstressdefenses,aswellasforthesynthesisofpentosesusedasnucleicacidprecursors.Thisprotocols.Oneprotocolconsistedofmethylprednisolone, ascorbicacid,thiamine,heparinandanumberofco-interventionsandthuswascalled“MATHþ”[26,27]