Assistive technologies dec:jan

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21/11/14

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INNOVATION FOR INDEPENDENCE

ISSUE 100 DECEMBER 2014/JANUARY 2015 £6.95

Studies to repair damaged spinal cord set to start

By Nicola Hyde CLINICAL studies will start next year in a pioneering project that uses cells from the nose to repair damaged nerves in the spinal cord and potentially ‘cure’ paralysis. A state-of-the-art clean room to culture cells is currently being completed at the UCL Institute of Neurology which will lead the research into use of Olfactory Ensheathing Cells (OECs) to repair brachial plexus avulsion, an injury common in motorcycle accidents when the nerve roots are pulled out of the spinal cord and the arm is left paralysed. The pioneering research from Professor Geoff Raisman was plunged into the spotlight last month when it appeared on BBC One's Panorama programme. The patient, Darek Fidyka, was paralysed after suffering stab wounds to the back in 2010, leaving an 8mm gap in his spinal cord. Scientists used the OECs that regenerate damaged cells in our nose to make repairs to his spinal cord. Professor Raisman first discovered OECs in 1985 and in 1997 successfully showed that they could be used to treat spinal injuries in rats. He has spent the past decade developing spinal repair techniques for patients.

He said: “It is immensely gratifying to see that years of research have now led to the development of a safe technique for transplanting cells into the spinal cord.

“I believe we stand on the threshold of a historic advance and that the continuation of our work will be of major benefit to mankind. “I believe we have now opened the door to a treatment of spinal cord injury that will get patients out of wheel chairs. “Our goal now is to develop this first procedure to a point where it can be rolled out as a worldwide general approach.” For the experimental treatment, Darek first underwent brain surgery to remove one of his olfactory bulbs, it was placed in a cell culture for two weeks to produce OECs. These were then injected into the spinal cord above and below the injury, and four strips of nerve tissue were taken from the ankle and patched across the 8mm gap. These formed ‘bridges’ for the spinal nerve fibres to grow across. Three months after the surgery, Darek’s left thigh muscle began to grow and after six months he was starting to walk within the rehabilitation centre with the help of a physiotherapist and leg braces.

A woman has modelled in a Marilyn Monroe inspired photo shoot – wearing a running blade encrusted with crystals. Belinda Gatland wanted the shimmering prosthesis for a charity photo shoot. Prosthetist Bob Watts worked closely with GlamSticks to create the glamorous end result. Belinda modelled the crystal leg to re-enact one of the most iconic images of the 20th Century; the infamous moment when Marilyn’s white dress blows up as she stands over a subway grate. Full story page 7


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