what’s new
Tensiometer
Molecular analysis profiling to identify cancer driver events
The DCAT 9 tensiometer from DataPhysics Instruments now includes intuitive software as well
The Affymetrix Concurrent Mo-
as an extended choice of different
lecular Analysis Profiling (Co-
measuring methods.
MAP) program enables cancer
The weight-based measurements
researchers to gain rapid insight
of the surface and interfacial ten-
into the functional impact of
sion are automatically steered and
DNA copy-number alterations
evaluated using the DuNoüy ring or
by combining whole-genome
the Wilhelmy plate method. In addition to the different dynamic and
copy-number data with gene expression profiles to easily visualise and identify cancer driver events.
static analysis options which can be
Recent whole-genome DNA analysis of cancer samples has demonstrated that copy-
used to evaluate temperature, the
number alterations affect more of the genome than any other DNA abnormality. Many
Langmuir trough offers a method
of these alterations are ‘drivers’ of cancer, while others are merely ‘passenger’ events.
of investigating surface coatings
Deciphering which DNA alterations are driver or passenger events has been a challenge.
or molecular self-organisation processes by chemical substances.
The CoMAP capability enables the concurrent correlation of genome-wide gene expression changes with copy-number alterations, helping to identify and prioritise the
The product is available in three
number of potential driver events - which in turn can lead to the identification of func-
different variants: DCAT 9, without
tional biomarkers. This is particularly valuable to researchers studying C class tumours,
TV 70 (temperature-controllable
which are characterised by functional copy-number changes, as opposed to somatic
vessel); DCAT 9T, including TV 70;
mutations (M class).
and DCAT 9M, including TV 70 and
The capability is included in the Affymetrix Chromosome Analysis Suite (ChAS) 3.0
a built-in magnetic stirrer. The inno-
Software, enabling researchers to analyse and visualise the functional impact of copy-
vative design and the high-quality
number changes on gene expression in cancer samples, including degraded FFPE tissue.
device components are said to
The capability instantaneously combines and correlates whole-genome copy-number data
ensure optimal support in research,
with mRNA and miRNA data generated from Affymetrix tools such as OncoScan FFPE
development and quality control.
Assay Kit, GeneChip Human Transcriptome Array 2.0 and GeneChip miRNA 4.0 Array.
Particle & Surface Sciences Pty Ltd
Correlation maps may be generated for all RefSeq genes or a customised gene list.
www.pss.aus.net
The approach enables researchers to go from samples to insights in just three days. Millennium Science Pty Ltd www.mscience.com.au
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LAB+LIFE SCIENTIST - June 2015 | 25