Ways to Manage Menopausal Symptoms Menopause comes with a host of symptoms that can make you feel awful emotionally and physically. Due primarily to declining levels of the hormone, estrogen, the unfamiliar and erratic symptoms that lead to and through “the change,” can wreak havoc on your overall sense of wellbeing. During the years of fertility, estrogen naturally fluctuates throughout the month, commensurate with a woman’s menstrual cycle. Then after 3 decades or so of having a monthly period, women enter perimenopause, which is a years-long process that reflects changing levels of estrogen related to decreasing fertility.