ASMA SEVERO RESPUESTA A BRONCODILATADORES

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Received: 29 January 2019

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Accepted: 12 July 2019

DOI: 10.1002/ppul.24473

ORIGINAL ARTICLE: ASTHMA

Clinical significance of the bronchodilator response in children with severe asthma |

Andrea M. Coverstone MD1

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Anne M. Fitzpatrick PhD

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Sally E. Wenzel MD

Leonard B. Bacharier MD1 4

William Gerald Teague MD 7

Benjamin M. Gaston MD

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Wendy C. Moore MD

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Sima Ramratnam MD

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Ngoc P. Ly MD, MPH

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John V. Fahy MD, MSc 15

Kenneth B. Schechtman PhD

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Bradley S. Wilson MA2

Eugene R. Bleecker MD 11

Nizar N. Jarjour MD

Huiqing Yin‐DeClue PhD

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David T. Mauger PhD14 15

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Wanda Phipatanakul MD, MS5 8

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Jonathan S. Boomer PhD15

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Mario Castro MD, MPH

1 Department of Pediatrics, Washington University School of Medicine in Saint Louis, St. Louis, Missouri

Abstract Background: Our objective was to determine those characteristics associated with

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Department of Ophthalmology and Visual Sciences, Washington University School of Medicine in Saint Louis, St. Louis, Missouri 3

Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 4

Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 5

Department of Pediatrics, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts 6

Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 7

Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, Ohio 8

Department of Medicine, University of Arizona, Tucson, Arizona 9 Department of Medicine, Wake Forest University School of Medicine, Winston‐Salem, North Carolina 10

Department of Pediatrics, University of Wisconsin School of Medicine, Madison, Wisconsin

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Department of Medicine, University of Wisconsin School of Medicine, Madison, Wisconsin

reversibility of airflow obstruction and response to maximal bronchodilation in children with severe asthma through the Severe Asthma Research Program (SARP). Methods: We performed a cross‐sectional analysis evaluating children ages 6 to 17 years with nonsevere asthma (NSA) and severe asthma (SA). Participants underwent spirometry before and after 180 µg of albuterol to determine reversibility (≥12% increase in FEV1). Participants were then given escalating doses up to 720 µg of albuterol to determine their maximum reversibility. Results: We evaluated 230 children (n = 129 SA, n = 101 NSA) from five centers across the United States in the SARP I and II cohorts. SA (odds ratio [OR], 2.08, 95% confidence interval [CI], 1.05‐4.13), second‐hand smoke exposure (OR, 2.81, 95%CI, 1.23‐6.43), and fractional exhaled nitric oxide (FeNO; OR, 1.97, 95%CI, 1.35‐2.87) were associated with increased odds of airway reversibility after maximal bronchodilation, while higher prebronchodilator (BD) FEV1% predicted (OR, 0.91, 95%CI, 0.88‐0.94) was associated with decreased odds. In an analysis using the SARP III cohort (n = 186), blood neutrophils, immunoglobulin E (IgE), and FEV1% predicted were significantly associated with BD reversibility. In addition, children with BD response have greater healthcare utilization. BD reversibility was associated with reduced lung function at enrollment and 1‐year follow‐up though less decline in lung function over 1 year compared to those without reversibility.

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Department of Pediatrics, University of California, San Francisco, San Francisco, California

Conclusions: Lung function, that is FEV1% predicted, is a predictor of BD response in children with asthma. Additionally, smoke exposure, higher FeNO or IgE level, and low peripheral blood neutrophils are associated with a greater likelihood of BD

Pediatric Pulmonology. 2019;1-10.

wileyonlinelibrary.com/journal/ppul

© 2019 Wiley Periodicals, Inc.

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