for Pregnant Women with Preeclampsia HELLP is on the Way
S
wollen ankles. Nausea.
complain of tingling fingers,
Headaches. Heartburn.
unusual swelling of the face,
The usual suspects in any
and vision problems, but
pregnancy, especially in the third
still look like a reasonably
trimester. With their due date
healthy pregnant person.
looming, most women endure these
Malaise and nausea don’t
discomforts knowing that the trials
warrant yet another trip
will soon be over. But for some,
to the gynecologist, she
these symptoms mask a deadly
thinks. But deep within
disorder, one of four potentially fatal
her system, her red blood
hypertensive disorders of pregnancy.
cells are exploding. The
Our grandmothers spoke of
“H” in HELLP, hemolysis,
“toxemia of pregnancy” in worried
is the rupturing of red
voices. To the older generation, a
blood cells and releasing
healthy pregnant woman could be
hemoglobin into the
stricken as if by poison, and dead
blood plasma. Elevated Liver
within a few hours.
enzymes and Low Platelet count all
Today the condition is known as preeclampsia, from the Greek word for lightning. Affecting up to 8 percent of pregnancies worldwide, it is impossible to predict. High blood pressure and protein in the
contribute to the HELLP syndrome. Traditional blood work takes several hours: coagulation panel, liver enzymes, renal functions. How can HELLP be diagnosed safely and effectively, and even inexpensively,
“It potentially can be sold in the drugstore,” Pyayt explains, “for the price of a pregnancy test.” In simple terms, a small box, which can be purchased or even created
in a matter of minutes?
on a 3D printer, slides over the
untreated, eclampsia can follow,
Enter Team Hemolix and Anna
the flash. A small blood sample is
including seizures and organ
Pyayt, PhD, assistant professor,
placed in the box, and allowed to
and director of the Innovative
remain still for seven minutes. The
Biomedical Instruments and Systems
app calibrates its environment in
(IBIS) Lab at the University of South
the box, takes a flash picture of the
Florida. And a free smartphone app.
vial, and analyzes the colors of the
And seven minutes. And a very
plasma and blood, now separating
small vial or a capillary tube with of
into layers. The app results are read
blood.
instantly and can be emailed to the
urine are the first symptoms. Left
failure. One of the most insidious complications of preeclampsia is aptly called “HELLP syndrome.” A woman can
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- By Janet Dawald
back of a smart phone, in front of
doctor in a matter of seconds.