USC Michelson Center for Convergent Bioscience 2025 Annual Report

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USC MICHELSON CENTER FOR CONVERGENT BIOSCIENCE

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Since its establishment in 2017, the Michelson Center for Convergent Bioscience has played a transformative role in fostering national and global scientific collaborations. By bridging disciplines and integrating diverse research communities, the center accelerates discovery and innovation, expediting the translation of groundbreaking ideas into real-world applications. Its mission is rooted in the belief that dismantling traditional disciplinary silos leads to a more dynamic and effective research ecosystem— one that fosters novel insights, enhances exploration, and ultimately drives life-saving advancements in medicine and technology.

At the heart of this initiative is Michelson Hall, a state-ofthe-art, 190,000-square-foot research facility made possible by a $50 million donation from orthopedic spinal surgeon Dr. Gary Michelson and his wife, Alya Michelson. With a total project cost of $185 million, Michelson Hall provides the critical infrastructure necessary for pioneering scientific research. Designed to promote openness, collaboration, and the free exchange of ideas, the facility embodies Dr. Michelson’s vision for a research landscape that prioritizes convergence and shared knowledge.

The 2025 Michelson Center Annual Report provides a comprehensive overview of the center’s initiatives and achievements from January to December 2024. It highlights the work of Michelson Faculty, showcasing their contributions to scientific advancement and the broader social impact of their research. This report also details key milestones, awards, and recognitions earned by faculty members, as well as provides an in-depth look at the research facilities, institutes, and centers housed within Michelson Hall. Additionally, the report presents financial insights into research lab funding and core facility operations, underscoring the center’s commitment to transparency and sustainability in scientific innovation.

Michelson Faculty were awarded over $41M in new grants last year by government entities and foundation sponsors, for project start dates of 2024. As well, the USC Office of Research and Innovation (OORI) made over $1M in research and instrumentation grant awards to Michelson Faculty. OORI’s awards supported the purchase of a Cryogenic Deep Reactive Ion Etcher housed at the John O’Brien core facility. Grants also fostered commercialization efforts (planning grants for faculty submitting SBIR proposals to federal agencies), increased national and international research collaborations, and advanced student training and access to research labs, helping to shape the next generation of scientists and thought leaders.

Alya Michelson and Gary K. Michelson Grand opening and ribbon cutting of the USC Michelson Center for Convergent Bioscience. November 1, 2017

Recognizing the importance of moving research from the bench to the bedside, the USC Stevens Center for Innovation provided extensive support to faculty in the commercialization of their research successes, so they can be developed into products and services that improve human lives, solve problems, and fuel economic growth. Twentyfour Michelson Faculty hold a total of 102 active unique patents.

Over 220 manuscripts were published in peer-reviewed journals by Michelson Faculty, who recognize that sharing research knowledge through scientific publications is essential for advancing collective understanding, fostering innovation, and ensuring transparency in the scientific community.

Growth and Research Capabilities

The number of Michelson Faculty—USC researchers whose laboratory is located at Michelson Hall and/or who are faculty directors of Michelson centers, institutes, and/or core facilities—has seen significant growth since the center’s inception. From an initial cohort of 20 faculty members, the Michelson community now comprises 46 distinguished researchers (10 new additions in 2024 alone). These faculty members hold appointments across multiple USC Schools, including the USC Viterbi School of Engineering, the Keck School of Medicine at USC, the USC Dana and David Dornsife College of Letters, Arts and Sciences and, more recently, USC Cinematic Arts.

Last year also saw growth in the number of core facilities, centers and institutes. Michelson Hall is home to six cutting-edge research centers and institutes, each dedicated to advancing specific areas of bioscience and biomedical engineering. These centers play a vital role in fostering interdisciplinary collaborations and pushing the boundaries of scientific discovery. The latest addition is the Transformative Center for Nanomedicine and Drug Delivery (TND), dedicated to spearheading advancements in therapeutic delivery by innovating nanotechnology and biomaterials solutions for drug and gene therapies.

Six core research facilities within Michelson Hall provide state-of-the-art resources and specialized equipment, enabling researchers to conduct high-impact studies that drive progress in fields such as molecular imaging, genomics, nanomedicine, and biomedical informatics. The Dynamic Imaging Science Center core facility is home to a Siemens MAGNETOM Aera 0.55T MRI scanner, the only MRI scanner of its type currently available to researchers world-wide. The Cell Culture Core, one of two core facilities associated with the Michelson Center Bridge Institute, achieved a significant milestone by receiving its designation as a USC Recharge Center. This designation marks a pivotal expansion, opening its doors and expertise to the broader Southern California research community. Michelson Hall core facilities invoiced over $912,185 in charges to USC users, not including income derived from charges made to non-USC researchers in industry and academia.

We recognize and celebrate the scientific breakthroughs and societal impact of Michelson Faculty—passionate innovators and relentless pioneers dedicated to shaping a healthier future. Their commitment to pushing boundaries and forging new frontiers in medicine reflects a resolute pursuit of progress that transforms lives.

It is also with deep gratitude that we recognize Dr. Gary Michelson’s unwavering commitment to develop groundbreaking life-saving devices and therapeutics. We are inspired by his belief in the limitless potential of bioscience to achieve “undreamed-of advances in the biological sciences in the near future” and, ultimately, to “make life less unfair.”

The Michelson Center for Convergent Bioscience stands as a testament to his visionary leadership, harnessing the power of scientific excellence, collaboration, and innovation to build a brighter and healthier world.

Silvia da Costa, Ph.D. Director, Research Initiatives & Infrastructure

Our Faculty

46 Current Michelson Faculty

10 new Michelson Faculty named in 2024

New Michelson Faculty School

USC Cinematic Arts joins the Michelson Center family of schools

5 Promotions

Michelson Faculty were promoted as Interim Dean of the Dornsife College, Distinguished Professor, Department Chair, Professor, and Associate Professor

1 Appointed

Vice President of Science Grant Programs at the Chan Zuckerberg Initiative

Funding

$1M in USC OORI Research Grants

Awarded by the USC Office of Research and Innovation to Michelson Faculty

$41M in New Grants

Awarded to Michelson Faculty by government sponsors, foundations and corporate entities for projects with a 2024 start date

115 Active and Pending Patents

Currently held by 24 Michelson Faculty

19 New Patent Applications

Submitted by 14 Michelson Faculty in 2024 Honors & Awards

5 Awardees

Women’s Cancer Research Fund Research Award (two awarded); Nanotechnology Characterization Laboratory; American Chemical Society Award for Creative Invention; IEEE Flanagan Speech and Audio Processing Technical Field Award

6 Fellows

Alfred P. Sloan Research Fellow in Chemistry; Packard Fellow for Science and Engineering; Fellow of the Royal Society of Chemistry; Fellow of the American Academy of Microbiology (two awarded); Institute of Electrical and Electronics Engineers Fellow

2 Sr. Members Elected

Senior Member of the Institute of Electrical and Electronics Engineers; Senior Member of the National Academy of Inventors.

2 Named Clarivate Researchers

Web of Science Highly Cited Researcher in Biology & Biochemistry

Centers & Institutes

1 New Center

The Transformative Center for Nanomedicine and Drug Delivery was established with the aim to spearhead advancements in therapeutic delivery, increasing the number of Centers at Michelson Hall to six

Multi-Center Events

Over 650 attendees participated in five events sponsored jointly by Michelson Centers. Conference and meeting topics included Drug Discovery, CryoEM, Biological Data Visualization, Mass Spec, and PFAS

Areas of Research

Michelson Centers advance research in areas of Informatics, Imaging, Drug Discovery, Cancer, Biomedical and Nanomedicine, among others

Training the Next Generation

A muti-Center undergraduate seminar and poster session drew over 250 attendees

Core Facilities

Invoicing to USC Users Surpasses $910,000

Does not include income derived from charges made to non-USC researchers in industry and academia

$400,000 Instrumentation Grant Awarded

By the USC Office of Research and Innovation to the John O’Brien Nanofabrication core for the purchase of a Cryogenic Deep Reactive Ion Etcher

6 Core Facilities

Areas of research include Biomolecular Characterization, Nanoimaging, Nanofabrication, Cell Culture, Structural Biology, and Dynamic Imaging

Publications

220 Articles Published By Michelson Faculty in peerreviewed journals

Publications in Highly Ranked Journals

Includes 23 in Nature publications, 29 in American Chemical Society journals, as well as publications in PNAS, Cell, IEE, JAMA, among others

Over 30 Publishers & Publication Types

Includes research articles, open access, conference papers, and others

Publication Research Areas

Includes biomedical, clinical, engineering, biological, and chemical sciences, among others

Data reflect a reporting period from January 1 to December 31, 2024 of grants awarded to Michelson Faculty.

Grants Awarded by USC Office of Research and Innovation

Amount Awarded INSTRUMENTATION GRANT

Rehan Kapadia, USC Viterbi School of Engineering Cryogenic Deep Reactive Ion Etcher

SBIR/STTR PLANNING GRANT

$397,511.96

$300,000.00

Vsevolod Katritch, USC Dornsife College Novel Angiotensin AT2 Receptor Antagonists for Neuropathic Pain Treatment

SBIR/STTR PLANNING GRANT

$150,000.00

Peter Yingxiao Wang, USC Viterbi School of Engineering Engineering Ultrasound Controllable CAR T Cells Targeting Intracellular KRAS Mutants in Solid Tumor

COLLABORATIVE RESEARCH PLANNING GRANT

$100,000.00

Gianluca Lazzi, Keck School of Medicine of USC Planning grant for the NSF Science and Technology Center for Digital Twin Neuroscience Across Space and Time (DiTNAST)

RESEARCH GRANT

$50,000.00

Yasser Khan, USC Viterbi School of Engineering Skin-Line Wearable Sensor Development for Diagnostic ECG and MRI At 0.55 T

STUDENT TRAINING/COMMERCIALIZATION GRANT

Ellis Meng, USC Viterbi School of Engineering Happy Halls (Student Empowerment Award)

INTERNATIONAL COLLABORATION TRAVEL GRANT

$15,000.00

$5,000.00

Shrikanth Narayanan, USC Viterbi School of Engineering Multi-Modal Representation Modeling For Monitoring Neurodegenerative Diseases

Total $1,017,511.96

† New awards made for projects with 2024 start date.

as PI†

Data reflect a reporting period from January 1 to December 31, 2024 of grants submitted by Michelson Faculty.

New Proposals Submitted as PI†

New Proposals Submitted

New Proposals Submitted as PI (continued)†

Commercializing scientific research bridges innovation with practical applications, driving economic growth and societal progress.

Summary of IP & Licensing†

Active & Pending Patents

ACTIVE & PENDING PATENTS (TOTAL)

Scott E. Fraser

Ellis F Meng

Shrikanth Narayanan

Maryam Shanechi

Krishna Shrinivas Nayak

Niema Mohammed Pahlevan

Vsevolod Katritch

Rehan Rashid Kapadia

Peter Kuhn

Gianluca Lazzi

Francesco Cutrale

Eun Ji Chung

Justin Haldar

Richard W Roberts

Mercedeh Khajavikhan

Jeremy Mason

Yasser Khan

Valery Fokin

Terry Takahashi

Remo Rohs

Charles McKenna

Jayakanth Ravichandran

James Hicks

Cristina Zavaleta

Licenses Executed

LICENSES EXECUTED (TOTAL)

Shrikanth Narayanan

Francesco Cutrale, Scott Fraser

Vsevolod Katritch

Scott Fraser

James Hicks, Peter Kuhn

Ellis Meng

Valery Fokin, Vsevolod Katritch

Vadim Cherezov

Peter Kuhn

Matthew Robert Pratt

Krishna Nayak

Patent and licensing data provided by USC Stevens Center for Innovation, Sophia Database.

“ Every great advance in science has issued from a new audacity of imagination. — John Dewey

Patent Applications for Calendar Year 2024

Eun Ji Chung

Natural Killer Cell-Derived Extracellular Vesicles as Potential Anti-Viral Nanomaterials

Scott E. Fraser

A Hyperspectral Imaging System with Hybrid Unmixing

Vsevolod Katritch

Opto-Opioids for Light-Induced, Local, Reversible Peripherally Restricated Analgesia

Yasser Khan

Ingestible Sensor or Treatment System and Method with Localization from Magnetic-Field Generating Wearable Device

Gianluca Lazzi

Electric-Field Directed Nerve Regeneration

Ellis F Meng

Thin Film Endovascular Electrode Array and Method of Fabrication

Francesco Cutrale

A Hyperspectral Imaging System with Hybrid Unmixing

Rehan Rashid Kapadia

Method of Fabricating Least Defective Non-planar Bipolar Heterostructure Transistors

Mercedeh Khajavikhan

Optical Neural Networks with Gain from Parity Time Optical Couplers

Peter Kuhn

Identifying Non-Disease Patients Using a Disease Related Assay and Analysis in the Liquid Biopsy

Jeremy Mason

Identifying Non-Disease Patients Using a Disease Related Assay and Analysis in the Liquid Biopsy

Jayakanth Ravichandran

Non-Destructive Imaging of Polar Domains and Crystallographic Symmetry in the Scanning Electron Microscope

Valery Fokin

Compounds and Methods for Modulating GPCR Signaling

Vsevolod Katritch

Compounds and Methods for Modulating GPCR Signaling

Mercedeh Khajavikhan

Parity Time-Symmetric Coupled

Distributed Feedback Lasers for Tunable THz Wave Generation

Peter Kuhn

Liquid Biopsy Analytes to Define Cancer Stages

Jeremy Mason

Liquid Biopsy Analytes to Define Cancer Stages

Remo Rohs

System and Method to Design a Set of Drug Molecules for a Target Receptor

Meet Our Faculty

OVERVIEW

Faculty members are the driving force behind groundbreaking research, serving as both innovators and mentors in the pursuit of scientific discovery. Their expertise, curiosity, and dedication fuel the research enterprise, transforming ideas into tangible advancements that address pressing global challenges. Whether pioneering new medical treatments, developing sustainable technologies, or expanding our understanding of fundamental biological and physical processes, faculty researchers play a critical role in pushing the boundaries of knowledge.

Beyond their individual contributions, faculty members create and sustain dynamic research ecosystems that foster collaboration across disciplines. They lead teams of students, postdoctoral fellows, and colleagues, bringing together diverse perspectives to tackle complex problems from multiple angles. Their ability to secure competitive grants, establish research partnerships, and drive institutional initiatives ensures that universities remain at the forefront of innovation.

Faculty also serve as mentors and educators, shaping the next generation of scientists, engineers, and thought leaders. Through hands-on training, guidance, and collaboration, they instill the skills, critical thinking, and creativity necessary for young researchers to thrive. This mentorship is essential not only for advancing individual careers but also for ensuring the long-term sustainability and impact of research endeavors.

Michelson Faculty — USC researchers whose laboratory is located at Michelson Hall and/ or who are faculty directors of Michelson centers, institutes, and/ or core facilities — continue to grow in number, currently 46 from the original 20 named faculty, and who have appointments with the USC Viterbi School of Engineering, the Keck School of Medicine of USC, USC Cinematic Arts and/or the USC Dana and David Dornsife College of Letters, Arts and Sciences.

New Michelson Faculty include:

• Professor Alexander McDowell, R.D.I., William Cameron Menzies Endowed Chair in Production Design; Professor of Practice in Media Arts; Director of World Building Media Lab and 5D Global Studio, USC Cinematic Arts. Professor McDowell is an awardwinning designer and storyteller working at the intersection of emergent technologies and experiential media.

• Dr. Andrew Steen, Ph.D., Associate Professor of Biological Sciences and Earth Sciences, USC Dana and David Dornsife College of Letters, Arts and Sciences. Dr. Steen’s lab uses bioinformatics, rate measurements, organic carbon characterization, and machine learning to understand the physical and chemical environment of Earth microbes, their metabolic requirements and their environmental histories to better understand how they influence — and are influenced by — the Earth’s geochemical cycles.

• Dr. Francesco Cutrale, Ph.D., Research Associate Professor of Biomedical Engineering, USC Viterbi School of Engineering. Dr. Cutrale’s research focuses on developing innovative tools for hyperspectral, multiplexed and multimodal imaging in biomedical

“ The true scientist never loses the faculty of amazement.
— Hans Selye

The four-story USC Michelson Center for Convergent Bioscience is a catalyst for discoveries in biological science, imaging, engineering, and nanofabrication.

research and translating them into real world applications for industry.

• Dr. Helen Berman, Ph.D., Research Professor and Board of Governors Distinguished Professor Emerita of Chemistry and Chemical Biology, USC Dana and David Dornsife College of Letters, Arts and Sciences. A co-founder of the Protein Data Bank (PDB) archive launched in 1971, her research has focused on nucleic acids, proteinnucleic acid interactions, and collagen. She is currently working on the Inner Space: World in a Cell VR experience that provides a view of the inside of a pancreatic beta cell.

• Dr. Ishwar K. Puri, Ph.D., Senior Vice President, Research and Innovation; Professor of Aerospace and Mechanical Engineering, USC Office of Research & Innovation. Dr. Puri’s research focuses on using magnetic fields to organize materials, including cells and tissues.

• Dr. Kandis Leslie Abdul-Aziz, Ph.D., Gabilan Assistant Professor of Civil and Environmental Engineering, USC Viterbi School of Engineering. Dr. Abdul-Aziz also serves as Director of the Sustainable Lab, focusing on developing novel materials for sustainable catalytic processes for low-carbon chemical production.

• Dr. Matthew Robert Pratt, Ph.D., Professor of Chemistry, USC Dornsife College of Letters, Arts and Sciences. Dr. Pratt’s research aims to understand the molecular consequences of modifications to cellular processes associated with changes in metabolism and stress. These modifications may contribute to a variety

of human diseases, including neurodegeneration and cancer.

• Dr. Peter Yingxiao Wang, Ph.D., Dwight C. and Hildagarde E. Baum Chair in Biomedical Engineering; Professor of Biomedical Engineering, USC Viterbi School of Engineering. Dr Wang’s lab is focused on the integration of biotechnologies in cellular and molecular engineering for the development of geneticallyencoded biosensors and their application to visualize molecular events in live cells and animals.

• Dr. Richard Brutchey, Ph.D., Professor of Chemistry, USC Dana and David Dornsife College of Letters, Arts and Sciences. His research focuses on the interface between active matter physics and cell biology, with a focus on the cellular cytoskeleton.

• Dr. Wade Zeno, Ph.D., Assistant Professor of Chemical Engineering and Materials Science, USC Viterbi School of Engineering. Dr. Zeno’s team uses quantitative fluorescence techniques to understand and control biomolecular systems.

As faculty members continue to push the limits of what is possible, their work remains essential to the mission of research institutions and to the broader scientific community, driving innovation and advancing knowledge across disciplines. By fostering collaboration, mentoring future researchers, and securing critical funding, faculty play a pivotal role in sustaining a thriving research ecosystem that fuels continuous progress. Their discoveries not only shape the future of science and technology, but also have profound impacts on society, healthcare, and industry.

USC Viterbi School of Engineering

Gabilan Assistant Professor of Civil and Environmental Engineering

Dani Byrd, Ph.D.

USC Dornsife College of Letters, Arts and Sciences Professor of Linguistics

Moh El-Naggar, Ph.D.

USC Dornsife College of Letters, Arts and Sciences

Interim Dean, USC Dornsife College of Letters, Arts and Sciences; Dean’s Professor of Physics and Astronomy

Kandis Leslie Abdul-Aziz, Ph.D.

Helen Berman, Ph.D.

USC Dornsife College of Letters, Arts and Sciences

Research Professor and Board of Governors

Distinguished Professor Emerita of Chemistry and Chemical Biology

Vadim Cherezov, Ph.D.

USC Dornsife College of Letters, Arts and Sciences

Ester Dornsife Chair in Biological Sciences; Professor of Chemistry

Stacey Finley, Ph.D.

USC Viterbi School of Engineering

Nicole A. and Thuan Q. Pham Professor; Professor of Biomedical Engineering, Chemical Engineering and Materials Science, and Quantitative and Computational Biology

James Boedicker, Ph.D.

USC Dornsife College of Letters, Arts and Sciences

Professor of Physics and Astronomy

Eun Ji Chung , Ph.D.

USC Viterbi School of Engineering

Dr. Karl Jacob Jr. and Karl Jacob III Early Career Chair; Director, Transformative Center for Nanomedicine and Drug Delivery; Associate Professor of Biomedical Engineering, Chemical Engineering, Medicine and Surgery

Valery Fokin, Ph.D.

USC Dornsife College of Letters, Arts and Sciences

Professor of Chemistry

Richard Brutchey, Ph.D.

USC Dornsife College of Letters, Arts and Sciences

Professor of Chemistry

Francesco Cutrale, Ph.D.

USC Viterbi School of Engineering

Associate Professor of Research, Biomedical Engineering

Peter Foster, Ph.D.

USC Dornsife College of Letters, Arts and Sciences

Assistant Professor of Physics and Astronomy

Scott Fraser, Ph.D.

USC Office of the Provost

Provost Professor of Biological Sciences and Biomedical Engineering; Elizabeth Garrett Chair in Convergent Bioscience; Director, Translational Imaging Center

Vsevolod Katritch, Ph.D.

USC Dornsife College of Letters, Arts and Sciences

Professor of Quantitative & Computational Biology, Chemistry and Pharmacology; Co-Director, Center for New Technologies in Drug Discovery and Development (CNT3D)

Gianluca Lazzi, Ph.D.

Keck School of Medicine of USC

Provost Professor of Ophthalmology, Electrical Engineering, Clinical Entrepreneurship and Biomedical Engineering; Fred H. Cole Professorship in Engineering; Director, Institute for Technology and Medical Systems

Cornelius

Gati, Ph.D.

USC Dornsife College of Letters, Arts and Sciences

Assistant Professor of Biological Sciences, Chemistry, Quantitative and Computational Biology and Pharmacology and Pharmaceutical Sciences

Steve Kay, Ph.D.

Keck School of Medicine of USC

Provost Professor of Neurology, Biomedical Engineering and Quantitative Computational Biology; Director of Convergent Bioscience; Co-Director, Rosalie and Harold Rae Brown Center for Drug Development, NCCC

Jeremy Mason, Ph.D.

Keck School of Medicine of USC

Assistant Professor of Research of Urology; Director of Data Science, Convergent Science Institute in Cancer

Justin Haldar, Ph.D.

USC Viterbi School of Engineering

Professor of Electrical and Computer Engineering; Co-Director, Biomedical Imaging Group; Director, Signal and Image Processing Institute

Carl Kesselman, Ph.D.

USC Viterbi School of Engineering

William H. Keck Professor of Engineering, Industrial and Systems Engineering, Computer Science, Population and Public Health Sciences, and Biomedical Sciences

Alexander McDowell, R.D.I.

USC Cinematic Arts

William Cameron Menzies Endowed Chair in Production Design; Professor of Practice in Media Arts; Director of USC World Building Media Lab and 5D Global Studio

James Hicks, Ph.D.

USC Dornsife College of Letters, Arts and Sciences

Professor (Research) of Biological Sciences

Mercedeh Khajavikhan, Ph.D.

USC Viterbi School of Engineering

IBM Early Career Chair; Professor of Electrical and Computer Engineering

Charles McKenna, Ph.D.

USC Dornsife College of Letters, Arts and Sciences

Professor of Chemistry and Pharmacology and Pharmaceutical Sciences; Director, Center for Drug Discovery

Khalil Iskarous, Ph.D.

USC Dornsife College of Letters, Arts and Sciences

Professor of Linguistics

Yasser Khan, Ph.D.

USC Viterbi School of Engineering

Assistant Professor of Electrical and Computer Engineering

Ellis Meng, Ph.D.

USC Dornsife College of Letters, Arts and Sciences

Professor and Chair of Biomedical Engineering

Rehan Kapadia, Ph.D.

USC Viterbi School of Engineering

Associate Professor of Electrical and Computer Engineering

Peter Kuhn, Ph.D.

USC Dornsife College of Letters, Arts and Sciences

University Professor; Dean’s Professor of Biological Sciences, Medicine, Biomedical Engineering, Aerospace and Mechanical Engineering and Urology; Director, Convergent Science Institute in Cancer

Shrikanth Narayanan, Ph.D.

USC Viterbi School of Engineering

Vice President of Presidential Initiatives; University Professor; Niki & Max Nikias

Chair in Engineering; Research Director and Distinguished Principal Scientist, Information Sciences Institute

Krishna Nayak, Ph.D.

USC Viterbi School of Engineering

Dean’s Professor of Electrical and Computer Engineering; Director, the Signal and Image Processing Institute, the Dynamic Imaging Science Center and the Magnetic Resonance Engineering Laboratory

Remo Rohs, Ph.D.

USC Dornsife College of Letters, Arts and Sciences

Professor of Quantitative and Computational Biology, Chemistry, Physics and Astronomy and Computer Science

Peter Yingxiao Wang, Ph.D.

USC Viterbi School of Engineering

Dwight C. and Hildagarde E. Baum Chair in Biomedical Engineering; Professor of Biomedical Engineering, Molecular Microbiology and Immunology

Niema Pahlevan, Ph.D.

USC Viterbi School of Engineering

Gordon S. Marshall Early Career Chair in Engineering; Associate Professor of Aerospace and Mechanical Engineering and Medicine

Maryam Shanechi, Ph.D.

USC Viterbi School of Engineering

Andrew and Erna Viterbi Early Career Chair; Associate Professor of Electrical and Computer Engineering – Systems, Biomedical Engineering, and Computer Science

Kate White, Ph.D.

USC Dornsife College of Letters, Arts and Sciences

Gabilan Assistant Professor of Chemistry

Matthew Robert Pratt, Ph.D.

USC Dornsife College of Letters, Arts and Sciences Professor of Chemistry

Andrew Steen, Ph.D.

USC Dornsife College of Letters, Arts and Sciences

Associate Professor of Biological Sciences and Earth Sciences

Cristina Zavaleta, Ph.D.

USC Viterbi School of Engineering

Associate Professor of Biomedical Engineering

Ishwar K. Puri, Ph.D.

USC Office of Research & Innovation

Senior Vice President, Research and Innovation; Professor of Aerospace and Mechanical Engineering

Terry Takahashi, Ph.D.

USC Dornsife College of Letters, Arts and Sciences

Assistant Professor (Research) of Chemistry

Wade Zeno, Ph.D.

USC Viterbi School of Engineering

Assistant Professor of Chemical Engineering and Materials Science

Jayakanth Ravichandran, Ph.D.

USC Viterbi School of Engineering

Philip and Cayley MacDonald Endowed Early Career Chair; Associate Professor of Chemical Engineering and Materials Science and Electrical and Computer Engineering

Ye Tian, Ph.D.

USC Viterbi School of Engineering

Research Assistant Professor of Electrical and Computer Engineering

Richard Roberts, Ph.D.

USC Dornsife College of Letters, Arts and Sciences

Professor of Chemistry, Chemical Engineering and Materials Science and Biomedical Engineering

Jennifer Treweek, Ph.D.

USC Viterbi School of Engineering

WiSE Gabilan Assistant Professor of Biomedical Engineering

HONORS & AWARDS

Kandis Leslie Abdul-Aziz

Elected: 2024 Alfred P. Sloan Research Fellow in Chemistry, a prestigious honor bestowed upon exceptional early-career scientists. Their achievements and potential place them among the next generation of scientific leaders in the U.S. and Canada.

Richard L. Brutchey

Elected: Fellow of the Royal Society of Chemistry (FRSC), in recognition of his significant and impactful contributions to the field of chemistry, particularly in areas of materials synthesis and sustainability research. Dr. Brutchey’s research focuses on developing new methods for materials synthesis, with applications in catalysis, energy storage, and sustainability.

Helen Berman

Dr. Berman was recognized for her work on the Protein Data Bank (PDB) in a speech by 2024 Nobel laureate Dr. John Jumper, who received the prestigeous honor for his work on protein structre prediction. Dr. Jumper praised Berman’s pioneering efforts in establishing the PDB, a digital repository for 3D protein structures, thanking the “giants on whose shoulders we stand on,” acknowledging Dr. Berman and others for their foresight in creating this open-access resource. Reported in USC Dornsife News Briefs, October 11, 2024.

Vadim Cherezov

Selected: 2024 Web of Science (Clarivate) Highly Cited Researcher in Biology & Biochemistry. The honor recognizes scientists having a significant and broad influence in their field, demonstrated by publishing multiple papers that rank in the top 1% of citations for their field and year within the Web of Science database. Only 1 in 1,000 researchers globally are considered Highly Cited Researchers.

Eun Ji Chung

Awarded: 2024 Nanotechnology Characterization Laboratory (NCL) awardee. The award made to Dr. Chung provides support to the project Detection of cancer spread to the lymph nodes by molecular targeting of CCR2. NCI founded the Nanotechnology Characterization Lab (NCL) in 2004, in collaboration with the US Food and Drug Administration and National Institute of Standards and Technology, as a public–private partnership to advance the science needed to expedite the development of promising nanotech therapies and diagnostics.

Moh El-Naggar

Elected: Fellow of the American Academy of Microbiology. The American Academy of Microbiology, a prestigious honorific leadership group within the American Society for Microbiology, annually elects fellows, through a highly selective, peer-review process that is based on their exceptional scientific achievements and original contributions that have significantly advanced the field of microbiology. Reported in USC Dornsife News, February 19, 2024.

Appointed: Interim Dean of USC Dornsife College of Letters, Arts and Sciences. Dr. El-Naggar, formerly the divisional dean for physical sciences, replaced Dean Amber Miller. Reported in USC Dornsife News, June 14, 2024.

Stacey Finley

Named: 2024 Senior Member of the Institute of Electrical and Electronics Engineers (IEEE), the world’s largest technical professional organization dedicated to advancing technology for the benefit of humanity.

Valery Fokin

Awarded: American Chemical Society (ACS) Award for Creative Invention. The award recognizes Dr. Fokin as a single inventor for the successful application of research in chemistry and/or chemical engineering that contributes to the material prosperity and happiness of people. She is recognized for “the invention of catalyzed dipolar cycloadditions—bioorthogonal click reactions widely used in chemistry, biology, medicine, and materials science.” August 27, 2024

Scott E. Fraser

Appointed: Vice President of Science Grant Programs at the Chan Zuckerberg Initiative (CZI), a philanthropy founded by Priscilla Chan and her husband Mark Zuckerberg, in 2015. Dr. Fraser will oversee science funding programs and help advance the organization’s strategy to support promising research, technology platforms, organizations, and scientific networks.

Justin Haldar

Promoted: Dr. Haldar was promoted to Professor of Electrical and Computer Engineering. He is also CoDirector, Biomedical Imaging Group and Director, Signal and Image Processing Institute at the Viterbi School of Engineering.

James Hicks

Awarded: 2024 - 2025 Women’s Cancer Research Fund (WCRF) Research Award for his innovative research investigating cancer from various angles and making an impact.

Vsevolod Katritch

Selected: 2024 Web of Science (Clarivate) Highly Cited Researcher in Biology & Biochemistry. The honor recognizes scientists having a significant and broad influence in their field, demonstrated by publishing multiple papers that rank in the top 1% of citations for their field and year within the Web of Science database .

Yasser Khan

Awarded: 2024 Packard Fellow for Science and Engineering. The Packard Foundation recognized Dr. Khan’s ideas for using a miniaturized sensor network of brain implants and ingestible sensors to study brain-gut communication. Reported in USC Viterbi News. October 15, 2024.

Named: Senior Member of the National Academy of Inventors (NAI). The prestigious honor recognizes Dr. Kuhn’s exceptional innovation in developing technologies that have significantly benefited, or have the potential to benefit, society. The appointment also acknowledges his achievements in securing patents, licensing, and commercializing his inventions, as well as his commitment to mentoring the next generation of inventors. Reported in USC Today, February 27, 2024.

Appointed: Distinguished Professor. The Distinguished Professor appointment, USC’s highest academic honor, is presented annually to select outstanding faculty who have brought great distinction and honor to USC through their work. Their research enlightens and enriches collective understandings outside of USC and contributes to the advancement of society.

Awarded: The 2024 - 2025 Women’s Cancer Research Fund (WCRF) Research Award for his groundbreaking cancer research with impactful, multi-angle approaches.

Shrikanth Narayanan

Elected: Fellow of the American Academy of Microbiology. The American Academy of Microbiology, a prestigious honorific leadership group within the American Society for Microbiology, annually elects fellows based on their exceptional scientific achievements and original contributions that have significantly advanced the field of microbiology. Reported in USC Dornsife News, February 19, 2024.

Awarded: 2025 IEEE Flanagan Speech and Audio Processing Technical Field Award, recognizing Dr. Narayanan’s groundbreaking contributions to speech communications science and technologies that foster inclusive, human-centered engineering. His research aims to understand how humans communicate and apply these insights to improving the human condition and experience. Reported in USC Viterbi News, September 19, 2024.

Maryam Shanechi

Named: Blavatnik National Awards Finalist. Dr. Shanechi was selected as a Blavatnik National Awards for Young Scientists Finalist for the second year in row – one of just five finalists across all areas of Physical Sciences and Engineering in the nation in 2024. Reported in USC Viterbi News. September 12, 2024.

Promoted: Dr. Shanechi was promoted to Alexander A. Sawchuk Chair in Electrical and Computer Engineering and Professor of Electrical and Computer Engineering, Biomedical Engineering, and Computer Science, USC Ming Hsieh Department of Electrical and Computer Engineering. Dr. Shanechi works at the interface of AI, machine learning, and dynamical systems to develop algorithmic solutions for basic and clinical neuroscience problems. November 8, 2024

Elected: Institute of Electrical and Electronics Engineers (IEEE) Fellow, for her research contributions to brainmachine interfaces. The grade of Fellow recognizes unusual distinction in the profession and is conferred by the Board of Directors upon a person with an outstanding record of accomplishments in any of the IEEE fields.

Cristina Zavaleta

Promoted: Dr. Zavaleta was promoted to Associate Professor of Biomedical Engineering at Viterbi’s Alfred E. Mann Department of Biomedical Engineering. Her research focuses on the development, assessment and clinical translation of new nano-based molecular imaging strategies to help clinicians detect cancers with better sensitivity and specificity.

Helen Berman

Speaker: USC Information Sciences Institute, Conferences, Lectures, & Seminars. AI in structural biology: roots of success. Dr. Berman described the history of the effort to achieve the successful prediction of protein structures by AlphaFold 2 using AI methods and how this breakthrough opened the doors to new research in structural and cell biology. Marina del Rey, CA. April 19, 2024.

Chair: VIZBI 2024: 14th International Meeting on Visualizing Biological Data. The event was co-sponsored by the USC Michelson Center, the USC Bridge Institute, Frontiers in Bioinformatics and the KAUST Visual Computing Center (detailed in Centers and Institutes section). March 12-15, 2024.

James Boedicker

Speaker: SoCalSysBio 2024. Signal exchange within bacterial communities. The annual symposium, sponsored by the UCI Center for Complex Biological Systems, is now in its 13th year and brings together researchers from across California to share research, build community, and stimulate collaborations. Irvine, CA. March 16, 2024.

Invited Speaker: American Physical Society (APS), Evolutionary Dynamics I Dynamics of the CRISPR array. Dr. Boedicker spoke on how a quantitative model of CRISPR array content and dynamics will aid the development of many future applications that utilize the CRISPR arrays for genome editing and may elucidate how CRISPR shapes genome evolution. Minneapolis, MN. March 4, 2024

Eun Ji Chung

Selected team: LA BioStart Bootcamp Silver Spur Therapeutics, a company co-founded by Dr. Chung, participated in the event. The Cal State LA BioStart Bioscience Entrepreneurs Boot Camp is an intensive, five-week program designed to equip aspiring bioscience entrepreneurs with the skills to launch their own ventures. This boot camp is a joint initiative by Cal State LA, the Biocom Institute, and the Los Angeles Cleantech Incubator. Funded by the U.S. Economic Development Administration, the program is offered at no cost to eligible participants.

Selected team: NIH Entrepreneurship Bootcamp Silver Spur Therapeutics, a company co-founded by Dr. Chung company, participated in the event. The Bootcamp is designed to equip life science investigators and nascent companies with specialized innovation and entrepreneurship training.

Speaker: University of Michigan, Department of Materials Science and Engineering, Ann Arbor, MI. September 27, 2024.

Speaker: Yonsei University, Department of Chemical Engineering. Using nanoparticles to drive effective drug delivery in cardiovascular and kidney disease. Seoul, South Korea. June 5, 2024.

Speaker: Taejon Christian International School. Nanomedicine. Daejeon, South Korea. June 4, 2024.

Speaker: Korea Institute of Toxicology (KIT). Micelle platform for mitigating cardiovascular and kidney diseases. Daejeon, South Korea. June 4, 2024.

Speaker: Keio University. Using nanobiomaterials to drive effective drug delivery and outcomes. Tokyo, Japan. May 23, 2024.

Speaker: Vanderbilt University, Renal Research Conference. Using nanoparticles to drive effective drug delivery for cardiovascular and kidney diseases. Nashville, TN. May 3, 2024.

Speaker: Purdue University, US-Korea Joint Webinar Series on Biomedical Engineering, and Career Development Forum, From macroscale to nanoscale biomaterials, and my journey from Korea to the States. West Lafayette, IN. June 13-14th, 2024.

Speaker: American Association of Nephrology. Advances in Research Conference - Genome Engineering and RNABased Therapeutics: From Bench to Potentially Curative Medicines. Novel kidney delivery approaches for genetic medicines. San Diego, CA. October 23, 2024.

Speaker: 22nd International Nanomedicine and Drug Delivery Symposium (NanoDDS2024) Biomimetic nanoparticles for chronic diseases. Orlando, FL. September 13-15th, 2024.

Speaker: Inaugural webinar series, Korean-American Biomedical Engineering Society (KBMES). From macroscale to nanoscale biomaterials, and my journey from Korea to the States. June 14, 2024.

Speaker: POSTECH Symposium. Biologically inspired carriers for nanomedicine. Pohang, Korea. May 31-June 2, 2024.

Speaker: International Science and Engineering Fair from Society for Science, Nanomedicine Biomedical engineering finalist networking session. Los Angeles, CA. May 11-17, 2024.

Speaker: SelectBio Extracellular Vesicles/Exosomes and Nanoparticles, Engineering EVs for cardiovascular diseases (shown above) Miami, FL April 3-4, 2024.

Speaker: Controlled Release Society (CRS) 2024 Annual Meeting and Exposition. Manufacturing science and technology. The presentation addressed “fouling”, i.e. the deposition and consequent loss of material onto the channel walls when producing nanoparticles in microfluidic processes. Bologna, Italy. July 9, 2024.

Speaker: 3rd Annual Allies in Innovation Celebration, Alliance for SoCal Innovation, ASU California Center. Keynote Fireside Chat, with Drs. Scott Fraser and Gary Michelson. Los Angeles, February 22, 2024.

Organizer: 18th International Conference on Crystallization of Biological Macromolecules - ICCBM18 (shown above). Tempe, AZ. November 3-9, 2024.

Francesco Cutrale

Stacey Finley

Organizer: SoCalSysBio 2024. The annual Southern California Systems Biology symposium (shown above) brought together researchers from across California to share research, build community, and stimulate collaborations. UCI, Irvine, CA. March, 16, 2024

Invited Co-chair: Keystone Symposia - From Systems Immunology to Immunoengineering, a joint meeting with the Immunometabolism Across Scales: From Cells to Systems to Healthspan meeting. Vancouver, BC, Canada. January 11-15, 2026.

Invited Speaker: FASEB Science Research Conference. Mathematical modeling reveals design features of NK cellbased immunotherapy. St. Paul, MN. June 2024.

Invited Speaker: Conference for Emerging Black Academics in STEM. Modeling the tumor ecosystem: modeling across scales. Caltech, Pasadena, CA, April 2024.

Invited Speaker: Computational Medicine Program Symposium Tumor-immune ecosystem: quantitative insights from modeling across scales. Chapel Hill, NC. March 2024.

Invited Speaker: Gordon Research Conference on Immunoengineering Systems biology modeling of the tumor-immune ecosystem. Lucca, Italy, February 2024.

Speaker: Systems Biology Theory Lunch Exploring the tumor ecosystem: modeling across scales. Harvard University, Department of Systems Biology, November 22, 2024.

Speaker: Computational Health Seminar Series. Exploring the tumor-immune ecosystem using multi-scale computational modeling. Duke University, Center for Computational Health and Digital Health Innovation, October 30, 2024.

Speaker: Tissue Talks Seminar Series Applying computational modeling to study immune cell signaling, metabolism, and angiogenesis. Columbia University, October 2, 2024.

Speaker: Chemical and Biomolecular Engineering Seminar Exploring the tumor ecosystem: modeling across scales. University of California, Irvine, May 31, 2024.

Speaker: Wheldon School of Biomedical Engineering BME Distinguished Research Seminar Series, Exploring the tumor ecosystem: modeling across scales. Purdue University, April 24, 2024.

Speaker: Distinguished Lecture in Mathematical and Computational Biology Exploring the tumor-immune ecosystem using multi-scale computational modeling. University of California, Riverside, February 21, 2024.

Peter Foster

Invited Speaker: TU Dresden Physics of Living Systems (shown above). From cytoskeletal assemblies to living machines. The event brough together experimentalists and theorists from across disciplines, interested in identifying the emergent principles that control the dynamic organization of living matter, especially when these principles underlie biological function. Dresden, Germany. June 19, 2024.

Cornelius Gati

Speaker: 2024 Structural Biology Summit (shown above). The interdisciplinary summit brought together experts in the fields of single particle cryo-EM, cryo-ET, and MicroED as well as software developers in X-ray crystallography and computational modeling to discuss current developments, challenges, and future opportunities. UCLA Lake Arrowhead Lodge, CA. October 15-18, 2024.

Organizer: 9th Annual Southern California CryoEM Symposium. SoCal CryoEM 2024 (detailed in Michelson Events section). October 11, 2024,

Speaker: Chemistry and Pharmacology of Drug Abuse (CPDA) Conference. Structural basis of inverse agonism via inactive kappa opioid receptor: G protein complexes Boston, MA. August 1, 2024.

Justin Haldar

Host: ECE Seminar. Capturing life: Optical microscopy for in vivo deep tissue imaging at high spatiotemporal resolution. USC Ming Hsieh Department of Electrical and Computer Engineering, Los Angeles, CA. March 25, 2024.

Khalil Iskarous

Speaker: Yale University, Monday Colloquium The dynamical emergence of discreteness in phonology. Dynamical Systems Analysis (DSA) studies the quantitative variation in the states of natural systems and the qualitative differences in the behaviors of such systems. Dr. Iskarous presented an introduction to dynamical systems and how the dynamical approach is being currently extended to the description of syntactic structure. New Haven, CT. September 30, 2024.

Vsevolod Katritch

Co-Organizers: Drs. Katritch and Charles McKenna, 2nd Annual Drug Discovery Innovation Workshop (CNT3D+Bridge+MESH Academy) (detailed in Centers & Institutes section). February 23, 2024.

Speaker: Chemistry and Pharmacology of Drug Abuse (CPDA) Conference. Giga-scale ligand screening and design: new tools for computer driven drug discovery Boston, MA. August 1, 2024.

Mercedeh Khajavikhan

Host: MHI Physics Joint Seminar Series Non-Hermitian quantum dynamics: super quantum correlations and breaking the quantum speed limit. USC, Los Angeles, CA. November 1, 2024.

Speaker: Distinguished Lecturer Series Mack Planck Institute Guiding trojan beams using LaGrange points. Leuchs-Russell Auditorium at the Max Planck Institute for the Science of Light. Erlangen, Germany. May 23, 2024.

Presenter: Symposium - Integrated Photonics and Quantum Applications. Leading experts in the field at the interface of nanophotonics, mid-infrared sensing, special materials and integrated systems spoke on the propelling promising advances in the world of quantum science. Laval University, Quebec, Canada. November 5, 2024.

Panelist/Chair: AI West Med, USC Keck School of Medicine, 6th Annual Practical Urology, Annual Artificial Intelligence Session. Taxonomy/historical perspective/ multidisciplinary AI teams. The conference covered advanced robotic, endo-urologic, endoscopic, imagetargeted, focal therapy, microsurgical, prosthetic, reconstructive surgeries, and their complications, as well as medical therapies covering the entire range of urology. Los Angeles, CA. Feb 1-3, 2024.

Panelist: USC Women’s Conference 2024 The power of collaboration to fight cancer. Panelists included USC’s Drs. Kuhn, Jorge Nieva, and Assad Oberai. The panel was moderated by Amy Ross (USC Trustee). Los Angeles, CA. March 1, 2024.

Keynote speaker: 12th International Clinical Cancer Genomics Conference, Accelerating Progress in Precision Medicine for Cancer: The Time is Now, Session 4: New Approaches to Early Diagnosis and Treatment of Inherited Cancers. The promise of multi-cancer detection assays. The goal of the event (shown above) was to equip healthcare providers with practical tools and knowledge to accelerate progress in precision medicine for cancer. It provided an interdisciplinary educational forum comprising updates on state-of-the-art science in cancer genomics, including artificial intelligence, discussed real-world cases, curated interesting pedigrees, and prepared case summaries in order to disseminate new knowledge and evidence-based management of high-risk patients and their at-risk family members. Chicago, Il. April 19-21, 2024.

Peter Kuhn

Peter Kuhn (continued)

Keynote speaker: Charles University, AI4BS – Artificial Intelligence for Body and Soul How can AI contribute and improve physical and mental health of a human being? The one-day conference (shown above) focused on what artificial intelligence can offer, and already offers, to people to support their physical and mental health. Prague, Czech Republic. May 23, 2024.

Alex McDowell

Keynote speaker: VIZBI 2024, Design and storytelling (shown right, detailed in Centers & Institutes section). March 13-15, 2024.

Keynote speaker: FAB24 - Symposium on Technology 5.0, Fab Initiative: Symposium on Technology 5.0 and Fab Initiative - DistInc and World Building. The annual FABx Event (shown above) is a global convening of creative and innovative thinkers who share a passion for digital fabrication and technology to promote equity and social justice through technological, frugal, and innovative solutions that address relevant social problems. Puebla, Mexico. August 5, 2024.

Keynote speaker: NEOM Museum. NEOM is a region in northwest Saudi Arabia that is being built as a living laboratory for entrepreneurship and innovation. NEOM aims to empower the best talents to embody pioneering ideas and exceed boundaries in a world inspired by imagination; a global hub that is reimagining urbanism to be people-first and nature-friendly. Kingdom of Saudi Arabia. November 18, 2024.

Dr. McDowell was a keynote speaker on design and storytelling at the international conference on Visualizing Biological Data (VIZBI 2024).

Dr. Meng was a symposium chair at the 13th Congress of the International Society for Autonomic Neuroscience in Birmingham, UK.

Ellis Meng

Symposium Chair: 13th Congress of the International Society for Autonomic Neuroscience. Bioelectronic medicine. The meeting (shown left) brought together the international community working in the field of autonomic neuroscience, both fundamental and clinical. Birmingham, UK. July 25-27, 2024.

Executive Program Chair: 2025 Transducers Conference. The mission of the international conference (shown above) is to enhance the collective knowledge of the global transducers technical community and to stimulate its growth by providing an inclusive forum for communication, education, and collaboration. To be held in Orlando, FL. June 29-July 3, 2025.

Speaker: West Virgina University, Materials Science Seminar. Scaling polymer implantable electrode interfaces. Morgantown, WV. April 26, 2024.

Speaker: 9th International Winterschool on Bioelectronics Scaling polymer implantable electrode interfaces. Tirol, Austria. March 16-23, 2024.

Speaker: Gordon Research Conference on Neuroelectronic Interfaces. Translating neural technologies using NIHfunded open-source platforms. The Neuroelectronic Interfaces GRC is an international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. Galveston, TX. March 10-15, 2024.

Speaker: University of Arizona, Biomedical Engineering Departmental Seminar. Polymer-based microfabricated implants for neural applications. Tucson, AZ. February 12, 2024.

Shrikanth Narayanan

Organizing Committee Member: INTERSPEECH 2024 Conference Series: Speech and Beyond. The conference paper State-of-the-art speech production MRI protocol for new 0.55 Tesla scanners included contributions by USC/ Michelson Faculty authors Drs. Narayanan, Ye Tian and Dani Byrd. Kos Island, Greece. September 1-5, 2024.

Ishwar K. Puri

Speaker: 2024 USC Architecture Research Symposium (shown above). Resilient futures: bridging tradition and innovation in the living environment. Los Angeles, CA. April 11, 2024.

Invited Speaker: Renewable Hydrogen Storage and Transport Conference. Dinner, Banquet, and Poster Session. USC, Los Angeles, CA. March 11, 2024.

Jennifer Treweek

Hosted: USC Alfred E. Mann Department of Biomedical Engineering - Seminar series Bayesian exploration for intelligent haptics and medical diagnosis. USC, Los Angeles, CA. September 13, 2024.

Cristina Zavaleta

Speaker: Molecular Imaging Program at Stanford (MIPS) Seminar Series. A resurgence in nano: the many advantages of nanoparticle-based imaging contrast agents and their potential for clinical translation. November 7, 2024.

Kandis Leslie Abdul-Aziz

From drug-detection to eco-entrepreneurship. Dr. AbdulAziz (shown above), a recent addition to the USC Sonny Astani Department of Civil and Environmental Engineering, is challenging conventional notions of waste. As the Gabilan Assistant Professor of Civil and Environmental Engineering and Director of the Sustainable Catalysis and Materials Laboratory, she is pioneering groundbreaking research that transforms discarded materials into valuable resources. Her innovative approach has earned her recognition as a 2024 Alfred P. Sloan Research Fellow in Chemistry. Reported in USC Viterbi News, February 26, 2024.

Helen Berman

Pioneering crystallographer Dr. Helen Berman helped to set up the massive collection of protein structures that underpins the Nobel-prize-winning tool’s success. Dr. Berman was interviewed by Nature in their News Q&A feature on October 18, 2024 about her work that was recognized by recent Nobel-prize winning scientists Drs. David Baker and John Jumper. Reported in Nature News Q&A, October 18, 2024.

Vadim Cherezov

Scientists search for safer, less addictive pain medications amid America’s rising opioid crisis. Research by Dr. Cherezov is further enhancing the understanding of the structure and function of proteins such as µOR, helping scientists create better drug treatments. Reported in USC Dornsife News, July 11, 2024.

Eun Ji Chung

Nemirovsky Engineering and Medicine Opportunity (NEMO) Prize: USC’s Office of the Senior Vice President for Health Affairs has awarded the university’s inaugural NEMO Prizes to two teams of USC researchers. One of the winning projects, RNA-BASED nanoparticle therapy for polycystic kidney disease, was awarded to Drs. Ken Hallows and Nuria Pastor-Soler, both from the Keck School of Medicine, in collaboration with Dr. Chung. The trio aims to perfect a therapy to target the root cause of polycystic kidney disease before patients need dialysis or a kidney transplant. Reported in USC Today, February 26, 2024.

USC researchers aim to control tissue growth with gamechanging applications. A team of USC researchers, supported by a Chan Zuckerberg Initiative grant, is working to revolutionize tissue engineering. Led by Drs. Megan McCain (Viterbi) and Leonardo Morsut (Keck), and in collaboration with Dr. Chung, the team is developing techniques to control how cells grow into tissue (shown above), with potential applications in neuromuscular diseases and other conditions. Their research could lead to significant advancements in regenerative medicine. Reported in USC Viterbi News, March 25, 2024.

Moh El-Naggar

IBM agreement boosts USC’s quantum computing leadership. USC signed a new agreement with IBM that gives the university’s researchers cloud access to IBM quantum systems (shown right), among other benefits. The agreement accelerates the Frontiers of Computing “moonshot,” a more than $1 billion initiative. Dr. El-Naggar explained how “this agreement reinforces USC’s leadership in quantum information science. Our faculty experts were ahead of their time in applying emerging quantum computers to address grand challenges in health and energy.” Reported in The Quantum Insider, March 12, 2024.

Electric bacteria: Out of the darkness and into the light Dr. El-Naggar is exploring how certain species of bacteria (shown above) could provide an interface between the living and nonliving worlds. Instead of using oxygen as the final electron acceptor for cellular respiration, some bacteria can use iron or manganese, effectively “breathing” metal. By leveraging the evolutionary expertise embedded in these organisms, he aims to develop hybrid electronics. Reported in The Scientist. February 29, 2024.

Scott Fraser

The Chan Zuckerberg Initiative (CZI) announced multiinstitutional collaborations for developing technology to better understand cells. Dr. Fraser, CZI Vice President of Science Grant Programs, is driving the collaboration of lab projects nationwide, focusing on emerging technologies to engineer cell and tissue models and explore cell responses. Reported in Chan Zuckerberg Initiative News, February 29, 2024.

Dr. El-Naggar helped facilitate an agreement with IBM to establish USC’s IBM Quantum Innovation Center and propel USC researchers and students toward new discoveries.

Yasser Khan

From wearables to swallowables: USC engineering researchers create GPS-like smart pills with AI. This breakthrough represents a significant step forward in ingestible technology (shown above), which Dr. Khan believes could someday serve as a “Fitbit for the gut” and for early disease detection. Reported in Viterbi News, June 12, 2024.

Rehan Kapadia

From elevator pitch to proof-of-concept in less than half the time. Part of the promise of the California Defense Ready Electronics and Microdevices Superhub (CA DREAMS), led by USC Viterbi’s Information Sciences Institute, is to facilitate the acceleration of breakthroughs and solutions through a lab-to-fab model — where university nanofabrication laboratories work closely with larger manufacturing facilities. Drs. Kapadia and Augusto Gutierrez-Aitken (Northrop Grumman) forged one of the earliest DREAMS working relationships at the USC Information Sciences Institute. Reported in USC Viterbi News, October 10, 2024.

Force multiplier: California DREAMS combines capabilities from university nanofabs: Dr. Kapadia, codirector of MOSIS 2.0, which resides in DREAMS, is a USC-led coalition involving university and industry collaborators to accelerate microelectronics production for 5G/6G and electromagnetic warfare. The superhub is working to standardize equipment and best practices across its partners. Reported in USC Viterbi News, June 21, 2024.

Building the next generation of chips. USC has been chosen by the Department of Defense to lead one of eight regional hubs dedicated to advancing chip development and manufacturing in the U.S. This initiative, funded by the CHIPS and Science Act, provides USC with an initial $27 million and supports Dr. Kapadia’s research into next-generation electronic and photonic devices and their underlying material science. Reported in USC Viterbi Magazine. Spring 2024.

Vsevolod Katritch

Michelson Faculty researchers are developing effective new remedies to relieve pain — without the risk of addiction: Dr. Katritch is researching how to design cannabinoids that selectively target CB2, cellular receptors that interact with compounds from the cannabis plant, to reduce pain. Two of his recent studies, including one conducted in collaboration with Dr. Valery Fokin, discovered several new compounds that target CB2. Their goal is to offer relief for those suffering from neuropathy and other pain conditions — without affecting cognitive function. Reported in USC Dornsife Magazine, July 11, 2024.

Steve Kay

USC researchers uncover biological circuit that protects plants from extreme conditions. A groundbreaking study funded by the National Institutes of Health has revealed how plants use their internal clocks to respond to fluctuating water and salt levels. Led by Dr. Kay, this research builds on years of work exploring the role of circadian rhythms in both plant and animal life. These findings could be crucial for developing strategies to improve plant resilience in the face of climate change. Reported in Keck News February 5, 2024.

Scientific speed dating - a culture of collaboration to ignite discovery in medicine. Dr. Kay, head of USC’s convergent research initiatives, spurs team science to change the landscape of health. More than 100 researchers from the Keck School of Medicine and the USC Viterbi School of Engineering convened for a daylong meeting for a somewhat less scholarly tradition — scientific speed dating. The match to be made was between complex problems in human health and the latest advances in big data and artificial intelligence. The event created an opportunity for the formation of new cross-disciplinary teams, as engineers from Viterbi and the USC Information Sciences Institute cycled through informal conversations with medical practitioners and investigators. Reported in Keck News, January 09, 2024.

Mercedeh Khajavikhan

Trojan Photons: trapping light in nowhere land using Lagrange points. USC Viterbi School of Engineering researchers, including leader, Dr. Khajavikhan, have reported the first observation of an exotic class of guided optical waves called Trojan beams. Counterintuitively, these photonic wavefronts are trapped in nowhere land – in completely inconspicuous regions where no conventional waveguide structures exist. Reported in Viterbi News, January 5, 2024.

Peter Kuhn

Blood filtration offers hope in the fight against pancreatic cancer. In a groundbreaking advancement of a novel cancer treatment, researchers have successfully deployed Seraph® 100 blood filtration media to demonstrate removal of Circulating Tumor Cells (CTCs) from the blood of patients suffering from advanced pancreatic cancer. The published results are foundational for ExThera Medical’s circulating tumor cell reducing device, the ONCObind™ Procedure Hemoperfusion Filter (ONCObind™), to pave the way for improved longevity and better outcomes by reducing or eliminating cancer metastasis. Research in the Kuhn lab aims to remove CTCs to potentially interrupt the metastatic process and improve patient outcomes. This device represents an opportunity to significantly improve the care for patients with pancreatic cancer and is potentially applicable to other forms of cancer. Reported in Yahoo! Finance, July 18, 2024.

Cancer detective wants to use liquid biopsy to change how the disease is diagnosed and treated. Dr. Kuhn’s research on liquid biopsies is poised to revolutionize cancer diagnosis and treatment. His blood test offers a less invasive alternative to traditional tissue biopsies, enabling early detection of cancer cells and personalized treatment plans. By analyzing the genetic makeup of cancer cells circulating in the bloodstream, the liquid biopsy technology empowers doctors to tailor therapies to each patient’s specific tumor characteristics, potentially transforming cancer from a deadly disease into a manageable condition. Reported in USC Dornsife News, July 11, 2024

Gianluca Lazzi

Up to $47 million award supports collaborative eye transplant research co-led by USC. The USC Roski Eye Institute at the Keck School of Medicine is one of eight organizations leading the project, known as Total Human Eye-allotransplantation Innovation Advancement (THEIA). The USC team includes Dr. Kimberly Gokoffski, a neuroophthalmologist and surgeon-scientist at the Keck School of Medicine, Dr. Lazzi, director of the USC Institute for Technology and Medical Systems, Dr. Mark Humayun, the inventor of an FDA-approved “bionic eye” device for restoring vision, and Dr. Arthur Toga, a world-renowned expert in brain imaging. Reported in USC Keck News, December 16, 2024.

Ellis Meng

Revolutionizing heart care for newborns. Dr. Meng’s team is developing non-invasive shunt monitoring to improve survival rates for babies with congenital heart defects. The technology monitors blood flow in these critical shunts, detecting blockages and irregularities early enough for timely, potentially life-saving interventions. Reported in USC Viterbi News, December 17, 2024.

Shrikanth Narayanan

Signal processing pioneer’s tech has improved autism diagnosis. Dr. Narayanan’s lab has developed tools that can interpret emotional cues. His lab developed both machine intelligence and signal processing technologies to study human behavior that includes facial expressions, spoken language, and physiological indicators. The technology, which analyzes and interprets speech and language in social situations, is useful for children with autism who typically have a difficult time with social interactions Reported in IEEE Spectrum News, November 27, 2024.

Niema Pahlevan

Device designed at USC aims to provide warnings of supersilent heart attacks. The Medical Flow Physics Laboratory (MFPL) at USC Michelson Center for Convergent Bioscience, under the direction of Dr. Pahlevan, provides an alternative to existing diagnostic tools that require either expensive medical equipment like an electrocardiogram, implanted devices or blood tests for proteins released during a cardiovascular event. The researchers have created an “instantaneous, inexpensive, and non-invasive method” to detect heart attacks independently from chest pain or electrocardiograms. Reported in Viterbi News. April 7, 2024.

Matthew Robert Pratt

The Pratt lab helps to advance treatment of neurodegenerative diseases. The lab was one of the first to exploit the method of protein synthesis for the sitespecific installation of O-GlcNAc, providing a greater understanding of how to approach the treatment of elusive, neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Multiple Systems Atrophy. Reported in USC Dornsife News, February 22, 2024.

USC Office of Research & Innovation launched a new research-focused video series “Coffee With Ish”. The video series (shown right) highlights the innovative and impactful work being led across the university by USC faculty. In the first set of videos, and using an informal conversation format, Dr. Puri interviews faculty whose research covers critical topic areas, ranging from sustainability to artificial intelligence, with a precedent placed on key disciplines relevant to the university’s strategic priority areas. Reported in USC Office of Research & Innovation News, April 26, 2024.

USC Viterbi & India: accelerating a strong partnership. A USC Viterbi delegation accompanied USC leaders (shown above) to further highlight and multiply the ties between USC Viterbi and India. The USC Viterbi contingent joined a larger group headed by President Carol Folt, including Dr. Puri and other colleagues. The USC contingent visited India between Jan. 14 and Jan. 19, with stops in Mumbai, Bengaluru and Delhi. During the trip, the Viterbi School delegation signed a partnership agreement with the Indian Institute of Technology Hyderabad to deepen educational and research ties. Reported in USC Viterbi News, February 15, 2024.

Dr. Puri and the Office of Research and Innovation have launched a video series — Coffee with Ish — to highlight the innovative work being led across the university by USC faculty.

A team of USC Viterbi researchers, led by Dr. Ravichandran, is investigating new materials to produce the highquality chips required to meet future data processing demands.

Jayakanth Ravichandran

National Engineer’s Day: role of advanced degrees in shaping engineering. For National Engineers’ Day in India, Dr. Ravichandran discussed the importance of various skills and disciplines to solve problems. Reported in USC Viterbi News, September 14, 2024.

A new method to grow materials for the chips of the future. (shown left) A team of USC researchers, led by Dr. Ravichandran, is investigating how to grow sulfurcontaining materials in thin film form. Reported in USC Viterbi News, June 19, 2024.

Tiny displacements, giant changes in optical properties. When it comes to certain crystals, properties vary dramatically when measured from different angles. A study published in Advanced Materials described a new pathway to obtain novel optical and electronic properties from structural disorder. Dr. Ravichandran and collaborators found that tiny displacements of just a few picometers in the atomic structure of a crystal (shown above) could have minimal impacts on optical properties in one direction but produce giant functional enhancements when viewed from another angle. Such functional enhancements could have practical applications in imaging, remote sensing and even medicine. Reported in Washington University News, May 6, 2024.

USC Sea Grant receives nearly $2 million from the National Oceanic and Atmospheric Administration (NOAA). The award supports research to develop a novel technology to turn marine debris into laundry detergent and sustainable dyes for the fashion industry. Dr. Roberts and collaborators are developing a disruptive and sustainable method for upcycling ocean-bound plastic waste (shown above) across Southern California waterways, and to investigate the psychology behind eco-conscious choices. Reported in USC Dornsife, August 27, 2024.

Remo Rohs

How artificial intelligence and computational biology are reshaping the quest for better medicines. Dr. Rohs (shown above) discussed the ongoing research at USC’s Department of Quantitative and Computational Biology as well as the role of artificial intelligence and the importance of computation. Reported in USC Dornsife News, July 11, 2024.

Andrew Steen

New faculty members further elevate USC Dornsife’s natural sciences prowess. Dr. Steen is one of five natural science professors who joined Dornsife College in 2024. His research studies the physical and chemical environment of Earth microbes to further understand how they affect and are affected by Earth’s geochemical cycles. Reported in USC Dornsife News, August 27, 2024.

Richard

Peter Yingxiao Wang

Turning a tumor’s “shield” into a weapon against itself. The Wang Lab has developed a new approach that turns the tumor cell’s defense mechanisms (“shield” molecules) into a target for the Wang Lab’s engineered Chimeric Antigen Receptor (CAR) T-cells that are programmed to attack cancer. Reported in USC Viterbi News, April 22, 2024.

Cristina Zavaleta

The rotisserie-inspired device that could revolutionize cancer surgery. Dr. Zavaleta and her team built a device, dubbed the Raman Rotisserie (shown above), that physically rotates the tumor specimen, utilizing Raman spectroscopy to scan the surface of the excised tumor. The aim is to guide surgeons to more precisely remove the remaining tumor and improve the success rate of breast cancer lumpectomies. Reported in Viterbi News, April 4, 2024.

TRAINING THE NEXT GENERATION

Kandis Leslie Abdul-Aziz

Speaker: PhD Informational Webinar (shown above). The event provided students information on PhD research opportunities in civil and environmental engineering at USC. November 12, 2024.

Richard Brutchey

Host: USC-Cerritos College Summer Research Internship in Sustainability 2024 Program. Conceived in 2010 by Drs. Brutchey and Jeff Bradbury, Professor of Chemistry at Cerritos College, the program pairs Cerritos undergraduate students (shown above) with graduate student mentors from USC Dornsife’s Department of Chemistry. Dr. Brutchey hosted two undergraduate students at his lab. The goal is to encourage community college students to pursue degrees in STEM fields, bringing together students and faculty to collaborate on basic research aimed at making a real-world impact. June 3 – July 26, 2024.

Dani Byrd

Speaker: USC PhonLunch. Dr. Byrd conducted a Professionalization Workshop for students and faculty interested in research in the areas of phonetic/phonological linguistics. The topics of PhonLunch meetings vary from week to week and range from research presentations to professional development. Reported in USC Dornsife PhonLunch. September 30, 2024.

Khalil Iskarous

Speaker: USC PhonLunch: Dr. Iskarous conducted a meeting for students and faculty interested in research in the area of phonetic/phonological linguistics. Reported in USC Dornsife PhonLunch. September 23, 2024.

Speaker: USC Linguistics Department, Small Talks

Learning in toddlers and large language models: a crossdomain linguistic comparison. Small Talks is USiL’s (Undergraduate Students in Linguistics) recurring event where professors, industry professionals, and researchers engage in direct panel discussions, providing an opportunity for students to gain insights from experts across diverse linguistics fields. March 4, 2024.

Yasser Khan

Undergraduate student research: developing new wearable sweat-rate sensors. The project, led by graduate student mentor Mohammad Shafiqul Islam at the Khan lab, undergraduate student Sangwon Cha (shown above) aims to improve the sweat rate of sensing wearables by creating a lower cost and more accurate sweat sensor that could wirelessly connect to smartphones via Bluetooth. Reported in USC Viterbi News. November 20, 2024.

Peter Kuhn

Mentored by Dr. Kuhn, USC junior Anya Shah analyzes fluorescent images of blood samples collected from individuals undergoing a diagnostic workup for lung cancer. Her research, identifying a variety of tumor cells circulating in the blood, is aimed at increasing the accuracy of those diagnoses, thereby improving patient care. Reported in USC Dornsife News. July 11, 2024

Jeremy Mason

Speaker: USC Associated Students of Biomedical Engineering (ASBME) BIOMED Research Symposium. My path to a career in cancer research. The symposium spotlights biomedical research at USC and includes a student poster symposium. September 2024.

Alexander McDowell

Professor McDowell participated in and spoke at a number of training events for students, sponsored by USC’s World Building Media Lab, including the Infinity Festival (March 29), the SY Partners innovation group (June 21), as well as presentations by the DG Information of Public Diplomacy, Director Public Diplomacy Foreign Affairs of Indonesia (July 17), and Dain Olsen, President, National Association Media Arts Education (August 7).

USC Michelson Center for Convergent Bioscience houses 30 labs, Class 100 and 1,000 Nanotechnology cleanrooms, imaging suites, and a large conference and classroom center.

Ellis Meng

The Maseeh Entrepreneurship Prize Competition (MEPC) 2024-2025: Innovation Meets Imagination. MEPC is the largest student prize awarded by a school at USC. At the event, held at the Michelson Center, Dr. Meng, USC Viterbi’s Vice Dean of Technology, Innovation, and Entrepreneurship, announced that Dr. Fariborz Maseeh, the program’s benefactor (shown above), had pledged to increase support for the competition, raising the grand prize amount from $50,000 to $100,000. Since the competition was launched 15 years ago, there have been over 469 total participants and more than $292 million raised by MEPC companies. MEPC places a strong priority on teaching entrepreneurship to student engineers. Reported in USC Viterbi News. November 4, 2024.

Shrikanth Narayanan

Speaker: Uniting Industry and Academia: 2024 Ming Hsieh Institute Research Festival. The day-long event celebrated innovative research by Ph.D. and undergraduate students through poster sessions and oral presentations, fostering collaboration among the USC Viterbi community, alumni and industry professionals. November 8, 2024

Interviewed: IEEE Professor Talk (shown above). Dr. Nayak spoke about his educational journey and research, which focuses on developing and clinically translating novel MRI technology. November 20, 2024.

Krishna Nayak

Centers & Institutes

Research centers and institutes foster collaboration, drive innovation and accelerate scientific advancements.

58 Overview

60 USC Michelson Center Events

64 The Bridge Institute

66 Translational Imaging Center

68 Center for Discovery Informatics

70 Center for New Technologies in Drug Discovery and Development

72 Convergent Science Institute in Cancer

74 Transformative Center for Nanomedicine and Drug Delivery

OVERVIEW

Fostering a spirit of inquiry and teamwork, research centers and institutes bring together diverse expertise, enabling groundbreaking research that addresses global challenges and pushes the frontiers of knowledge.

They are essential to driving progress across all fields of science, providing environments that support rigorous scholarship, foster collaboration, and inspire innovation.

Centers and institutes promote interdisciplinary research, encouraging researchers to work together, leading to novel insights and breakthroughs that would be impossible to achieve within more traditional, siloed research settings.

Furthermore, they play a vital role in disseminating knowledge to the broader public, fostering public understanding of scientific advancements and informing policy decisions. They are critical economic engines, fostering entrepreneurship and creating high-skilled jobs that fuel economic growth.

The USC Michelson Center for Convergent Bioscience is home to six centers and institutes. The most recent addition, the Transformative Center for Nanomedicine and Drug Delivery (TND), was established in 2024 by founding director Dr. Eun Ji Chung to spearhead advancements in therapeutic delivery.

Michelson centers and institutes are highly interdisciplinary and support a diverse network of scientists, engineers and scholars from USC Dornsife College of Letters, Arts and Sciences, USC Viterbi School of Engineering, USC Davis School of Gerontology, Keck School of Medicine of USC, and Children’s Hospital Los Angeles.

Importantly, Michelson centers and institutes serve as crucial training grounds for the next generation of researchers, offering unique opportunities for mentorship, hands-on experience and the development of essential skills. From the biomedical sciences to the social sciences, engineering, and environmental studies, they offer students exposure to cutting-edge research and immersive training that equips them with critical thinking abilities needed to tackle some of the world’s most pressing challenges and lead future advancements in their respective fields.

“ One finger cannot lift a pebble. — Hopi proverb

USC MICHELSON CENTER EVENTS

Research Centers and Institutes from diverse fields are vital to advancing knowledge and innovation. Holding joint events and conferences allows these institutions to collaborate effectively, exchanging expertise, ideas, and resources. Such collaborations lead to interdisciplinary solutions for complex global challenges, including climate change, public health, and technological progress. By coming together through these shared platforms, they can address multifaceted issues with a more comprehensive and impactful approach. These events foster creativity, accelerate technological development, and drive societal progress, making collaboration through joint gatherings essential for tackling the rapidly evolving challenges of today’s world.

Listed here are events held at the Michelson Center in 2024 that were jointly sponsored by various Michelson Institutes, Centers, and industry partners.

2nd Annual Drug Discovery Innovation Workshop

Organized by USC Drs. Vsevolod (Seva) Katritch and Charles McKenna and co-sponsored by CNT3D, the Bridge Institute and the MESH Academy, the event aimed to catalyze USC drug discovery and to spark drug research across the university. The workshop, held February 23, 2024, brought together over 200 scientists from USC and the SoCal biotech community to discuss new ways to expand and accelerate drug discovery efforts and develop new drug discovery technologies. The 3rd Drug Discovery Innovation Workshop will be held in Michelson Center on February 28, 2025.

Learn more about this event: Drug Discovery Innovation Workshop →

9th Annual SoCal CryoEM Symposium

Organized and hosted by Dr. Cornelius Gati and cosponsored by the USC Michelson Center, the Bridge Institute, Amgen, Thermo Fisher Scientific, Gatan, Nanosoft, Structura Biotechnology and the USC Core Center of Excellence in Nanoimaging, the event hosted nearly 300 researchers, enthusiasts and experts in cryoelectron microscopy to present, network and discuss cutting-edge CryoEM Structural Biology applications. The symposium, held October 11, 2024 at the USC Michelson Center and the Seeley Mudd building, featured a presentation by USC Professor Dr. Helen Berman, a keynote by Harvard Medical School Professor Hao Wu, as well as presentations by 15 graduate students and postdocs.

Learn more about this event: SoCal CryoEM Symposium →

14th International Meeting on Visualizing Biological Data

Co-sponsored by the USC Michelson Center, the Bridge Institute, Frontiers in Bioinformatics and the KAUST Visual Computing Center, the event, held March 12-15, 2024, was the first time VIZBI hosted their annual meeting on the west coast and included a satellite Masterclass Training session. Attended by more than 70 people, the meeting featured talks from 21 world-leading researchers, with a keynote presentation by Alex McDowell, RDI, USC Cinematic Arts. The event showcased visualizations that are transforming how life scientists view data, driving key advances in molecular biology, systems biology, biomedical science, and ecology. It brought together a diverse community, including bioinformaticians, data scientists, medical illustrators, graphic designers, and graphic artists, among others. USC Dr. Helen Berman served as Session Chair. Learn more about this event:

LA Mass Spec Day

The Los Angeles Metropolitan Mass Spectrometry (LAMMS) group organized the inaugural LA Mass Spec Day symposium at USC Michelson Center. The event, held April 2, 2024, facilitated networking and education for early-career scientists who are on the cusp of establishing their own research labs or venturing into the pharmaceutical and biotechnology industries. Event co-sponsors were Agilent, MOBILion, Bruker, Thermo Fisher Scientific, Waters, Evosep, Syft and Amgen.

Learn more about this event:

LA Mass Spec Day →

PFAS and Emerging Contaminants Seminar

The seminar, held April 24, 2024, highlighted the latest solutions to address challenging problems in environmental and related applications. Participating organizations included Blue Triton Brands, California Science Center Foundation, Enviro Labs, Irvine Ranch Water District, Los Angeles Department of Water and Power, MOBILion Systems, Orange County Sanitation District, Orange County Water District, Pacific Toxicology Laboratories, Physics Environmental Labs, Positive Lab Service, University of Southern California (Chemistry Department, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences and Keck School of Medicine of USC), USDA, USSL and UC Riverside.

Learn more about this event:

PFAS and Emerging Contaminants Seminar →

Bridge Undergraduate Science and BUGS Jr. Summer Research Finale Symposium

The 10th year of the BUGS/Jr. summer research programs was celebrated in a day-long summer finale symposium. Held August 3, 2024, the event has been hosted at Michelson Hall since 2018 and this year’s symposium featured 37 oral and 13 poster presentations by undergraduate students to an audience of more than 250 people. The program has become a catalyst for engagement with students and faculty across USC schools, including USC Dornsife School of Letters, Arts and Sciences, USC Viterbi School of Engineering, Keck School of Medicine of USC, USC Davis School of Gerontology, and USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences.

Learn more about this event:

BUGS and BUGS Jr. Symposium →

The BUGS and BUGS Jr. programs are training the next generation of students to surmount disciplinary boundaries, create professional networks, and engage in world-class research.

THE BRIDGE INSTITUTE

Steering Committee:

• Dr. Helen Berman, Bridge Institute Steering Committee Member

• Dr. Valery Fokin, Bridge Institute Steering Committee Member

• Dr. Stephen Bradforth, Bridge Institute Steering Committee Member

The Bridge Institute is a hub for groundbreaking biomedical research, dedicated to exploring the intricate connections between molecules, cells, and tissues. Through a unique blend of team-based science and artistic expression, it aims to uncover novel mechanisms that can revolutionize healthcare and improve human lives.

The Institute’s mission is to disrupt traditional research paradigms by fostering transdisciplinary convergence. By uniting experts from diverse fields—including science, engineering, medicine, and the arts—it aims to achieve radical progress in understanding and addressing complex biological challenges.

Building upon the legacy of the Michelson Center for Convergent Bioscience, the Bridge Institute serves as a nexus of intellectual capital. Its faculty, drawn from the USC Dornsife College of Letters, Arts and Sciences; the USC Viterbi School of Engineering; the Keck School of Medicine of USC; and the USC Cinematic Arts, bring together a wealth of expertise and creativity. By providing a collaborative platform that supports interdisciplinary research and training, the institute empowers researchers to explore new frontiers and make significant contributions to biomedical science.

Events

BCLA Healthcare Summit @ Michelson, Biotech Connection Los Angeles (BC-LA) hosted the 9th annual Healthcare Summit at Michelson Hall and was co-sponsored by the Bridge Institute. Attended by over 100 people, the event brought together leading experts, thought leaders, and innovators from the field of gene therapy. The event featured a keynote presentation by Dr. Nick Goeden, CTO Capsida Biotherapeutics, and panel that addressed the potential and emerging trends within gene therapy, offering attendees a comprehensive overview of current developments. May 17, 2024.

The Translational Imaging Center (TIC) aims to integrate cutting-edge imaging methods with biological research to translate scientific discoveries into applications that benefit medicine and health. The center supports both basic and translational research, focusing on innovation in imaging techniques that can enhance our understanding of cellular processes, tissue dynamics, and organ system functions.

Events

The SoCal Zebrafish Meeting: The conference, co-hosted with Children’s Hospital Los Angeles, brought together researchers from Southern California research institutions using zebrafish as a model system to present their work and collaborate. November 15, 2024.

Leica Mica Microhub Imaging Workshop - Seminar and hands-on demonstration of a Mica microscope, Leica’s automatic confocal and wide-field imaging system. July 16-19, 2024.

The TIC held quarterly Imaging Contests in 2024: Recent winners were graduate students Shahd Bawarith and Lynne Cherchia, and postdoctoral scholars Falk Schneider (above left; Tissue Zipper, image of Zebrafish hindbrain labeled with a green fluorescent membrane marker) and Masahiro Kitano (above right; Funky Fish, Confocal image of postfertilization zebrafish).

Training the Next Generation

The TIC provided students at all educational levels with research opportunities, including: Bence Peti-Peterdi, Ph.D. candidate for the SOAR - Student Opportunity for Academic Research program; Margaret Struble and Alexis Castaneda, Ph.D. candidates for the NSF Graduate Research Fellowship program; Margaret Struble and Oscar Alberto De La Fuente, Ph.D. candidates for the American Heart Association Predoctoral Fellowship; Ph.D. graduates Shanshan Cai (Biomedical Engineering), Peter Luu (Molecular Biology) and Anna Nadtochiy (Quantitative Computational Biology); as well as mentored undergraduates participating in the USC Bridge Institute’s BUGS (Bridge Undergraduate Science) program.

Confocal live image of a P0 (day of birth testis) seminiferous tubule (Image courtesy of Carol Readhead).

CENTER FOR DISCOVERY INFORMATICS

Center Director:

Convergent bioscience research is an interdisciplinary approach that integrates knowledge, methods, and technologies from multiple scientific fields—such as biology, chemistry, physics, engineering, and computer science—to address complex biological challenges. Such research flourishes in an environment where diverse data streams—from microscopy, mass spectrometry, flow cytometry, sequencing, and other modalities—intersect to create a rich and expansive body of knowledge. At Center for Discovery Informatics (CDI), discovery informatics plays a pivotal role in overcoming the challenges of data management, providing the essential abstractions, methods, and infrastructure that enable transformative discoveries in complex biological systems.

CDI bridges the gap between data and bioscience breakthroughs by offering user-friendly tools, highperformance computing, and a data-driven foundation that empowers researchers to navigate complex data, uncover hidden insights, and drive new discoveries, particularly in personalized healthcare solutions. The center supports collaborating scientists in addressing the critical challenge of effectively capturing, organizing, and sharing data as part of the discovery process. Additionally, CDI explores how integrating advanced technologies with everyday scientific practices can create opportunities for developing sophisticated analysis, data mining, visualization, and interaction methods.

Through its innovative research program, CDI is pioneering new approaches to data management and analysis, continuously pushing the boundaries of what is possible in complex biological systems. By combining expertise in computer science and informatics, CDI fosters a collaborative environment that transforms how knowledge is created, explored, and ultimately translated into meaningful benefits for humankind.

CENTER FOR NEW TECHNOLOGIES IN DRUG DISCOVERY AND DEVELOPMENT

Center Directors:

• Dr. Vsevolod Katritch, Co-Director

• Dr. Charles E. McKenna, Co-Director

The Dornsife Center for New Technologies in Drug Discovery and Development (CNT3D) develops, promotes, and applies cutting-edge technologies, including AI/ computational, systems and structural pharmacology, and click chemistry. In the two years since it was established, CNT3D has become a major research hub for the USC community and beyond, publishing over 60 collaborative papers, filing over 12 patent applications, and supporting the submission of more than 20 external grant proposals. Drug discovery campaigns in collaboration with several labs at USC Dornsife College of Arts, Letters, and Sciences, Keck School of Medicine of USC, and the USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences have led to the discovery of hits and leads for more than 10 key targets in pain, addiction, cancer, and Alzheimer’s disease.

The first company born from the CNT3D projects (AT2Rx Inc.) is pursuing further development of its preclinical candidate for treatment of neuropathic pain.

Institute Directors:

• Dr. Peter Kuhn, Director

• Dr. James Hicks, Deputy Director

• Dr. Jeremy Mason, Director of Data Science

• Dr. Liya Xu, Director of Applied Genomics

The vision of the Convergent Science Institute in Cancer (CSI-Cancer) is driven by a commitment to improve the quality of care for cancer patients through addressing complex challenges in cancer using convergent science. Placing the patient at the heart of its mission, CSICancer unites researchers from diverse disciplines to collaborate on groundbreaking research. The center aims to integrate patient data, model systems, and highcontent single-cell data with advanced machine learning techniques, transforming clinical observations into a deeper understanding of cancer’s physical and biological mechanisms. Research at CSI-Cancer is structured around the physical dynamics of cancer, examining spatial patterns and the temporal progression of the disease at cellular, individual, and population levels.

Events

115th American Association for Cancer Research (AACR) Annual Meeting 2024. Six poster presentations were made by CSI members at the conference, held in San Diego, CA, April 6-10, 2024.

Training the Next Generation

CSI-Cancer CURE Symposium. The Cancer Undergraduate Research Experience (CURE) program is the undergraduate program of USC Michelson CSI-Cancer Institute. The CURE Symposium is held twice a year and gives students an opportunity to present to a scientific community, as well as to mentors, friends, and family. Each student is assigned a mentor who helps them work on a research project, engage in project and institute meetings, and participate in institute activities. Twenty-one undergraduates presented their research at the 2024 annual symposium.

Center Director:

• Dr. Eun Ji Chung, Director

The Transformative Center for Nanomedicine and Drug Delivery (TND) was established in 2024 by founding director Dr. Eun Ji Chung with the aim to spearhead advancements in therapeutic delivery. Its interdisciplinary team, comprising experts from the USC Viterbi School of Engineering, USC Davis School of Gerontology, Keck School of Medicine of USC, and Children’s Hospital Los Angeles, is dedicated to innovating nanotechnology and biomaterials solutions for drug and gene therapies.

Supported by the Department of Biomedical Engineering, it aims to lead nanotechnology and biomaterials strategies to improve therapeutic outcomes and diagnostic capacity. Its mission is to create new therapeutic technologies and delivery solutions to combat diseases, to translate innovations for patient use, to develop a broad and strong network across academia, industry and the clinic, and to train the next generation of scientists and engineers who will lead new nanoscale to macroscale delivery advancements.

Additionally, at USC specifically, the Center will:

• Establish deeper and compelling research track records supported by institutional infrastructure in nanomedicine, drug delivery, and gene therapy;

• Support researchers that have viable drugs that require formulation science; and

• Scale and support the translational and research capabilities of nanomedicine and drug delivery efforts at USC.

Events

The TND sponsored a Therapeutics and Drug Delivery Retreat, held at the Langham Huntington, Pasadena, October 10, 2024. The goal of the retreat was to provide attendees opportunities to understand infrastructure, opportunities and challenges for therapeutic translation at the USC/Los Angeles community.

The day-long retreat was attended by 30 participants, all with an invested interest in therapeutic translation, from the Keck School of Medicine of USC, the USC’s Viterbi School of Engineering, Leonard Davis School of Gerontology, Norris Cancer Center, Stevens Center for Innovation, MESH Academy, Office of Research and Innovation, Advancement, Viterbi Office of Corporate and Foundation Relations, as well as Children’s Hospital Los Angeles and the Ellison Institute for Transformative Medicine. Sessions included Research and Advances into the Clinic and Unique Resources at USC, CHLA, and Los Angeles and Therapeutic Modalities for Diseases, Success and Failures from USC Research into the Clinic and Existing Infrastructure at USC and Los Angeles. Additionally, two panel discussions were held: Academic-Entrepreneurship, Industry Collaborations, Challenges and Opportunities at USC and Los Angeles, and Connecting People in Translational Therapeutic Research, Infrastructure Opportunities and Challenges, What Are Our Next Steps?

Core Facilities

Research core facilities are essential for providing advanced resources and expertise, enabling cutting-edge scientific discoveries.

In This Section

78 Overview

80 Agilent Center of Excellence in Biomolecular Characterization

82 Center of Excellence in Nano Imaging

84 John O’Brien Nanofabrication Laboratory

86 Bridge Institute Cell Culture Core

88 Bridge Institute Structural Biology Center Core

90 Dynamic Imaging Science Center

OVERVIEW

Michelson Hall’s shared core facilities serve as a hub where collaboration meets cutting-edge technology, providing researchers across disciplines with access to advanced instrumentation, worldclass technical expertise, and specialized consultation services. These facilities are designed not only to equip investigators with stateof-the-art tools but also to foster interdisciplinary synergy, breaking down research barriers and driving breakthroughs with national and global impact.

Operating on a fee-for-service model, the cores efficiently consolidate resources, ensuring equitable access to emerging and specialized research technologies that might otherwise be costprohibitive. The six core facilities housed within Michelson Hall support a diverse range of scientific endeavors, offering expertise and services in robotics, imaging, biomolecular characterization, and the development of novel peptides and antibody-like proteins, among many others. By expanding access to these critical resources, Michelson Hall strengthens the foundation for transformative discoveries and innovation.

In 2024, Michelson Hall core facilities invoiced over $912,185 in charges to USC users, not including income derived from charges made to non-USC researchers in industry and academia.

USC Support of Michelson Core Facilities

USC’s Office of Research and Innovation (OORI) Instrumentation Award is designed to expand the university’s research infrastructure by funding the purchase of cuttingedge instruments. OORI’s Shared Instrumentation Award provides costsharing support for instrumentation proposals submitted to programs such as the National Institutes of Health (NIH) S10 and the National Science Foundation (NSF) Major Research Instrumentation (MRI) program, along with other federal, state, and private funding sources.

Grants awarded in 2024 include a $397,511 Instrumentation Award to Michelson faculty Dr. Rehan Kapadia for the proposal Cryogenic Deep Reactive Ion Etcher for the purchase of an inductively coupled plasma (ICP) deep reactive ion etcher (DRIE) with atomic layer etching (ALE) module (PlasmaPro 100 Cobra 300). The instrument, to be housed at Michelson’s John O’Brien Nanofabrication core facility, will be utilized to carry out high-rate and high-precision etching of a range of semiconductor and polymer materials with state-of-theart control.

By equipping researchers with the tools they need, OORI is fostering groundbreaking discoveries and advancing Michelson Center leadership in scientific excellence. OORI’s award programs encourage collaborations between researchers and industry partners to create instruments with wider applicability and the potential to unlock entirely new research avenues. They also support the training of future leaders, allowing graduate and undergraduate students to gain invaluable hands-on experience with industry-standard equipment, preparing them for successful careers in research.

“ Science is not a collection of facts; it is a process of discovery.
— Robert Zubrin

AGILENT CENTER OF EXCELLENCE IN BIOMOLECULAR CHARACTERIZATION

Core Directors:

• Dr. Valery Fokin, co-Director

• Dr. Richard Roberts, co-Director

The Agilent Center of Excellence (COE) in Biomolecular Characterization is an example of the power of collaboration: a dynamic partnership between the Michelson Center, the University of Southern California, and Agilent Technologies, a global leader in life sciences, diagnostics, and applied chemical markets. Nestled within Michelson Hall at USC’s University Park campus, the COE represents a significant investment in the future of life sciences research.

This innovative research facility was conceived with a clear vision: to foster convergence. By bringing together researchers from diverse scientific and engineering disciplines, the Agilent COE facilitates multidisciplinary approaches to address some of the most pressing challenges in human health. The Center serves as a hub for collaborative exploration, driving the development of groundbreaking new drugs, diagnostics, and medical devices.

At the heart of the Agilent COE lies its commitment to providing access to cutting-edge technology. Equipped with an array of advanced instrumentation and technologies, the Center empowers diverse research groups, including faculty, graduate students, and the broader scientific community, welcoming researchers from institutions beyond USC to leverage the Center’s unique capabilities. This access is crucial for pushing the boundaries of scientific knowledge, to accelerate biomolecular characterization and propel advanced discoveries in the life sciences, translating research into tangible benefits for human health.

The breadth and versatility of the instrumentation housed within the facility support a wide spectrum of research activities, making the Agilent COE an asset for the entire region and contributing to the advancement of scientific understanding across numerous fields. This open-access model fosters collaboration, knowledge sharing, and accelerates the pace of innovation in the biomolecular sciences.

COE Events

Seminar: Agilent sustainability program introductory seminar: Implementing the Agilent sustainability goals to improve sustainability in operations and through innovative products and technologies, and to inform customers on how to achieve their sustainability objectives. July 17, 2024.

Seminar: Cell Analysis. The seminar introducing USC researchers and faculty members to Agilent’s latest cell analysis instrumentation and technologies. The focus was on how these tools can facilitate research and propel projects forward. November 7, 2024

CENTER OF EXCELLENCE IN NANO IMAGING

Core Directors:

• Dr. Jayakanth Ravichandran, co-Director

• Dr. James Boedicker, co-Director

The Core Center of Excellence in Nano Imaging (CNI) plays a crucial role in advancing scientific frontiers by fostering the development and application of cutting-edge nano-imaging tools. CNI’s core mission is to empower researchers to visualize, analyze, and interpret structures and features across the nano- to meso-scale, encompassing both engineered materials and natural systems, including complex biological structures. As a vital resource for the scientific community, CNI provides access to state-of-theart instrumentation and specialized expertise, enabling researchers to explore and understand the intricacies of the nanoscale.

CNI offers comprehensive support services tailored to researchers at all levels of experience, including training programs designed to equip new users with the skills and knowledge necessary to effectively utilize the core’s advanced instrumentation. CNI also recognizes the importance of collaboration beyond academia and extends its services to industry and other external partners, facilitating the translation of research discoveries into practical applications.

The core’s state-of-the-art facility houses a suite of advanced instrumentation, including a powerful array of electron microscopes, sophisticated X-ray tools, and a range of complementary instruments. This latest technology provides researchers with the essential tools needed to probe the complexities of the nanoscale world, driving innovation and discovery across a multitude of scientific fields. CNI’s commitment to open access to these resources establishes it as a vital hub for nano-imaging research and a key contributor to the advancement of scientific knowledge.

The Core’s administrative structure is comprised of CoDirectors, who provide strategic vision and leadership. An Internal Advisory Committee, composed of experts in the field, provides guidance and ensures that CNI remains at the forefront of nano-imaging research. This leadership structure ensures that CNI is responsive to the evolving needs of the scientific community and remains firmly dedicated to its core mission.

The “Clean Room” at the John O’Brien Nanofabrication Laboratory.

JOHN O’BRIEN NANOFABRICATION LABORATORY

Core Directors:

• Dr. Rehan Kapadia, Director

• Dr. Shiva Bhaskaran, Associate Director

The Michelson Center is committed to advancing research and education in the critical field of nanotechnology, and its nanofabrication facilities stand as a cornerstone of this commitment. These facilities comprise two distinct cleanrooms: the John O’Brien Nanofabrication Laboratory, dedicated to cutting-edge research, and the Powell Teaching Laboratory, focused on hands-on education and training.

As vital core facilities, these cleanrooms are accessible to all members of the USC research community, from faculty and students to postdoctoral researchers and staff. Furthermore, recognizing the importance of collaboration and knowledge sharing, these facilities are also available to external users from other academic institutions, industry partners, and government agencies.

The combined capabilities of the O’Brien and Powell Laboratories provide researchers with access to a comprehensive suite of advanced instrumentation. This breadth of equipment enables the facilities to support the diverse and evolving research activities at USC, spanning a wide range of disciplines. From fundamental studies of quantum transport, pushing the boundaries of our understanding of matter at the atomic level, to innovative nano/bioconvergent research, integrating nanotechnology with biological systems for applications in medicine, environmental science, and more, the nanofabrication facilities provide the essential tools and resources.

Researchers can fabricate novel materials, create intricate devices, and develop new processes, all within a controlled and state-of-the-art environment. The O’Brien Nanofabrication Laboratory serves as the primary research hub, equipped with advanced tools for nanofabrication, characterization, and analysis. Researchers utilize this space to explore new frontiers in areas such as semiconductor devices, microfluidics, photonics, and nanomaterials.

The Powell Teaching Laboratory plays a critical role in training the next generation of scientists and engineers. This dedicated teaching space provides students with hands-on experience in nanofabrication techniques, allowing them to develop practical skills and a deep understanding of the principles underlying nanotechnology. By providing access to these facilities, USC is cultivating a pipeline of skilled professionals who will contribute to the advancement of this rapidly evolving field.

The USC nanofabrication facilities are not isolated entities. They are integral components of a thriving research ecosystem at USC, complementing several other core facilities on campus. This interconnected network of resources fosters collaboration, accelerates research progress, and maximizes the impact of USC’s investment in research infrastructure. The continued development and support of these facilities are essential to maintaining USC’s leadership in this critical area of science and engineering.

Awards

In May 2024, Michelson Faculty member Dr. Rehan Kapadia was awarded a grant in the amount of $397,511 from USC’s Office of Research and Innovation Instrumentation Award program for the proposal Cryogenic Deep Reactive Ion Etcher for the purchase of a PlasmaPro 100 Cobra 300 to be housed at Michelson’s John O’Brien Nanofabrication core facility.

BRIDGE INSTITUTE CELL CULTURE CORE

Core Director:

The Bridge Institute Core Facility (BCCC) specializes in a range of essential cell culture services, providing researchers with the critical resources and expertise they need to advance their work. Its core competencies include baculovirus expression using SF9 insect cells, mammalian expression utilizing HEK-293F suspension cells, and the specialized plating of adherent cells for high-quality imaging. Beyond these specialized services, the core facility also provides essential support in cell maintenance, cell banking, mycoplasma testing, cell culture lab setup, and expert consulting. This comprehensive suite of services streamlines the research process, allowing investigators to focus on their core scientific questions.

In 2024 the core facility achieved a significant milestone: its designation as a USC Recharge Center. This designation marks a pivotal expansion, opening its doors and expertise to the broader Southern California research community. This expansion has fostered new collaborations and facilitated the sharing of knowledge and resources within the scientific community. By making its expertise and advanced technologies available to a wider audience, the core facility is accelerating the pace of discovery and contributing to the advancement of critical research areas.

The impact of the core facility is evident in the significant contributions it has made to a diverse range of research projects. Its work has been instrumental in supporting the crystallization and structure determination of numerous G protein-coupled receptors (GPCRs), a critical area of research with implications for drug discovery, within the laboratories of Dr. Raymond Stevens and Dr. Vadim Cherezov. The facility has also supported antibody expression and soluble protein expression, further demonstrating its versatility and impact. Beyond GPCR research, the core facility supports the work of Dr. Kate White in pancreatic beta cell signaling, providing crucial resources for understanding and combating diabetes. It also contributes to the cutting-edge cryoEM studies of GPCRs and solute carriers led by Dr. Cornelius Gati, as well as the innovative work of Dr. Peter Foster exploring the physics of living systems, including cytoskeletal activity and physical bioenergetics. Furthermore, the facility supports Dr. Scott Fraser’s team in their pioneering efforts in imaging and molecular analysis of intact biological systems, pushing the boundaries of our understanding of complex biological processes.

With its expertise in a wide range of cell culture activities, the Bridge Institute CCC welcomes projects beyond its existing portfolio and encourages collaborations with external labs. The facility is equipped to support a variety of both adherent and suspension cell cultures, operating under both BSL1 and BSL2 conditions, ensuring the safety and integrity of research conducted within its walls. The foundation’s support is critical in enabling the core facility to continue its vital work, providing researchers with the essential resources they need to make groundbreaking discoveries and translate those discoveries into tangible benefits for human health.

BRIDGE INSTITUTE STRUCTURAL BIOLOGY CENTER CORE

Core Directors:

• Dr. Fariborz Nasertorabi, Director

• Dr. Gye Won Han, Co-Director

The Structural Biology Center (SBC) serves as a premier core facility providing specialized services and expertise in molecular biology, biochemistry, and structural biology. With a broad repertoire of biochemical research capabilities, the SBC supports scientists in navigating the complex journey from gene to protein, including protein expression, stability, characterization, and complex formation. The center also plays a pivotal role in solving the three-dimensional structures of macromolecules using X-ray crystallography and single-particle Cryo-Electron Microscopy (Cryo-EM), offering researchers essential tools for understanding biomolecular mechanisms at the atomic level.

Over the past ten years, SBC has provided high-impact services and expert consultation to more than fifty research laboratories at USC and beyond, contributing to significant advancements in biomedical and biochemical research. The center has also developed unique methodologies and protocols, tailored to meet the evolving needs of its collaborators.

Recognizing the power of collaboration in driving scientific innovation, SBC has launched SBC@Bridge, a unifying initiative designed to connect structural biology groups across USC. Established by a consortium of researchers newly integrated into the university, SBC@Bridge fosters an interactive and interdisciplinary research environment, strengthening ties between labs and enhancing productivity through shared knowledge and resources.

Beyond providing world-class structural biology services, SBC plays a crucial role in advancing training of the next generation of researchers. Through specialized workshops, hands-on training sessions, and mentorship programs, the SBC equips students, postdoctoral fellows, and faculty with the skills and knowledge to leverage advanced techniques such as X-ray crystallography and Cryo-Electron Microscopy (Cryo-EM). By nurturing a community of skilled structural biologists, SBC ensures that expertise continues to grow and evolve, contributing to sustained scientific progress.

As a driving force behind groundbreaking discoveries, the SBC remains committed to excellence, accessibility, and innovation. Its dedication to supporting researchers, facilitating collaboration, and advancing structural biology not only strengthens biomedical research at USC but also has a far-reaching impact on the broader scientific community. Through its continued efforts, SBC is shaping the future of molecular and structural biology, paving the way for new insights into the fundamental mechanisms of life and the development of novel therapeutic strategies.

DYNAMIC IMAGING SCIENCE CENTER

DISC Management and Oversight Board:

• Dr. Dani Byrd, Management and Oversight Board (MOB) member

• Dr. Justin Haldar, MOB member

• Dr. Khalil Iskarous, MOB member

• Dr. Shrikanth Narayanan, MOB member

• Dr. Krishna Nayak, MOB member

The Dynamic Imaging Science Center (DISC) is dedicated to advancing an understanding of human movement and physiological function in both health and disease through the development and application of cutting-edge, noninvasive imaging technologies. By integrating advanced imaging techniques with real-time physiological monitoring, DISC provides researchers with an unparalleled platform to investigate the biomechanics and underlying processes that govern essential human functions, including movement, speech, and cardiopulmonary activity. Through this interdisciplinary approach, the center is paving the way for groundbreaking discoveries that have the potential to transform clinical diagnostics, rehabilitation strategies, and therapeutic interventions.

DISC is supported through a collaborative partnership between the National Science Foundation (NSF), the USC Viterbi School of Engineering, and Siemens Healthineers. This strategic alliance brings together leading experts in engineering, imaging technology, and healthcare to drive breakthrough discoveries and innovative solutions. To support its diverse research activities, The core facility is administered by a Management and Oversight Board and is staffed by a full-time research scientist and an on-site scientist from Siemens, ensuring that researchers have access to technical expertise, cutting-edge imaging tools, and ongoing advancements in MRI technology.

At the core of DISC’s capabilities is a state-of-the-art 0.55 Tesla whole-body MRI scanner, specifically optimized for capturing dynamic biological processes with unprecedented clarity. Unlike conventional imaging systems, this highperformance MRI is uniquely designed to visualize realtime movement and physiological responses, enabling scientists to analyze complex, time-sensitive interactions within the body. The system is further enhanced by a comprehensive suite of physiological monitoring tools, including electromyography (EMG), respiratory sensors, and cardiac monitoring devices, allowing for synchronized imaging and physiological data collection. This integration ensures a more precise and holistic understanding of the human body’s dynamic functions.

Beyond its technological innovations, DISC serves as a collaborative hub where engineers, neuroscientists, physiologists, and clinicians come together to push the boundaries of medical imaging and human performance research. Through interdisciplinary partnerships, the center facilitates novel studies on neuromuscular disorders, speech impairments, respiratory conditions, and cardiovascular function, among other critical areas.

A fundamental part of DISC’s mission is to train the next generation of scientists and clinicians in dynamic imaging technologies. Through specialized workshops, hands-on training sessions, and research opportunities, the center provides students, postdoctoral researchers, and faculty with the expertise needed to leverage these powerful tools in their own investigations.

By continuously innovating and expanding its capabilities, DISC is shaping the future of biomedical research and clinical practice. With its commitment to technological excellence, interdisciplinary collaboration, and education, DISC is not only driving scientific discovery but also opening new avenues for diagnosing, treating, and understanding a wide range of human health conditions and performance research.

The Dynamic Imaging Science Center core facility is home to a Siemens MAGNETOM Aera 0.55T MRI scanner, the only MRI scanner of its type currently available to researchers worldwide.

Publications

Publications are the building blocks of science, sharing knowledge and advancing

This Section

OVERVIEW

Scientific publications play a crucial role in advancing knowledge and fostering innovation within academic and research communities. They serve as a primary means of disseminating new discoveries, experimental results, and theoretical advancements to a wider audience, contributing to the collective intellectual growth of society. These publications are not only the cornerstone of academic achievement but also a testament to the rigorous inquiry and collaboration that underpin meaningful scientific progress.

For university centers, scientific publications serve as an essential tool for building academic reputation and demonstrating the impact of their research initiatives. High-quality publications signal to external stakeholders—such as funding agencies, industry partners, and the wider scientific community—that the center is contributing valuable insights and advancing the frontiers of knowledge. Moreover, they highlight the center’s commitment to rigorous scholarship and foster an environment where students and researchers can engage with the latest developments in their discipline. These publications, in turn, often attract new collaborations, support opportunities, and recognition from both within and outside the academic community.

A strong record of publications not only reflects the university center’s academic excellence but also underscores its role in addressing real-world issues through scientific inquiry. For students, publishing their work fosters a sense of accomplishment and provides valuable experience in the communication and dissemination of research, further enhancing their academic and professional development.

In 2024, over 220 manuscripts were published in peer-reviewed journals by Michelson Faculty, who recognize that sharing research knowledge through scientific publications is essential for advancing collective understanding, fostering innovation, and ensuring transparency in the scientific community.

“ There is a single light of science, and to brighten it anywhere is to brighten it everywhere.
— Isaac Asimov

MANUSCRIPTS & PUBLICATIONS

Kandis Leslie Abdul-Aziz

Jo, S.; Woo, J. H.; Kim, J. E.; Kim, T. Y.; Ryu, H. J.; Hwang, B.; Kim, J. C.; Lee, S. C.; Gilliard-AbdulAziz, K. L. Harnessing Ammonia as a Hydrogen Carrier for Integrated CO. ACS Appl Mater Interfaces 2024, 16 (51), 7057570586. DOI: 10.1021/acsami.4c16632.

Jo, S.; Gilliard-AbdulAziz, K. L. Self-Regenerative NiDoped CaTiO. Small 2024, 20 (36), e2401156. DOI: 10.1002/smll.202401156.

Helen Berman

Lawson, C. L.; Kryshtafovych, A.; Pintilie, G. D.; Burley, S. K.; Černý, J.; Chen, V. B.; Emsley, P.; Gobbi, A.; Joachimiak, A.; Noreng, S.; et al. Outcomes of the EMDataResource cryo-EM ligand modeling challenge. Nature Methods 2024, 21 (7), 1340-1348. DOI: 10.1038/ s41592-024-02321-7.

Zalevsky, A.; Sagendorf, J.; Tangmunarunkit, H.; et al. IHMCIF: An extension of the PDBx/mmCIF data standard for integrative structure determination methods. J Mol Biol 2024, 436 (17), 168546. DOI: 10.1016/j.jmb.2024.168546.

Vallat, B.; Berman, H. M. Structural highlights of macromolecular complexes and assemblies. Curr Opin Struct Biol 2024, 85, 102773. DOI: 10.1016/j. sbi.2023.102773.

James Boedicker

Zhao, F.; Niman, C. M.; Ostovar, G.; Chavez, M. S.; Atkinson, J. T.; Bonis, B. M.; Gralnick, J. A.; El-Naggar, M. Y.; Boedicker, J. Q. Red-light-induced genetic system for control of extracellular electron transfer. ACS Synth Biol 2024, 13 (5), 1467-1476. DOI: 10.1021/acssynbio.3c00684.

Ostovar, G.; Boedicker, J. Q. Phenotypic memory in quorum sensing. PLoS Comput Biol 2024, 20 (7), e1011696. DOI: 10.1371/journal.pcbi.1011696

Richard L. Brutchey

Pan, B.; Madani, M. S.; Forsberg, A. P.; Brutchey, R. L.; Malmstadt, N. Solvent dependence of ionic liquid-based pt nanoparticle synthesis: Machine learning-aided in-line monitoring in a flow reactor. ACS Nano 2024, 18 (37), 25542-25551. DOI: 10.1021/acsnano.4c05807.

Karadaghi, L. R.; Williamson, E. M.; To, A. T.; Forsberg, A. P.; Crans, K. D.; Perkins, C. L.; Hayden, S. C.; LiBretto, N. J.; Baddour, F. G.; Ruddy, D. A.; et al. Multivariate Bayesian optimization of CoO nanoparticles for CO. J Am Chem Soc 2024, 146 (20), 14246-14259. DOI: 10.1021/ jacs.4c03789.

Kleinhanns, T.; Milillo, F.; Calcabrini, M.; Fiedler, C.; Horta, S.; Balazs, D.; Strumolo, M. J.; Hasler, R.; Llorca, J.; Tkadletz, M.; et al. A route to high thermoelectric performance: solution-based control of microstructure and composition in Ag2Se. Advanced Energy Materials 2024, 14 (22), 2400408. DOI: https://doi.org/10.1002/ aenm.202400408.

Pan, B.; Karadaghi, L. R.; Brutchey, R. L.; Malmstadt, N. A Multistep, multicomponent extraction and separation microfluidic route to recycle water-miscible ionic liquid solvents. Ind Eng Chem Res 2024, 63 (1), 489-497. DOI: 10.1021/acs.iecr.3c03312.

Dani Byrd

Oh, M.; Byrd, D.; Goldstein, L.; Narayanan, S. S. Vertical larynx actions and intergestural timing stability in Hausa ejectives and implosives. Phonetica 2024. DOI: 10.1515/ phon-2023-0052.

Vadim Cherezov

Barekatain, M.; Liu, Y.; Archambeau, A.; Cherezov, V.; Fraser, S.; White, K. L.; Hayes, M. A. Insulator-based dielectrophoresis-assisted separation of insulin secretory vesicles. Elife 2024, 13. DOI: 10.7554/eLife.74989.

Belousov, A.; Maslov, I.; Orekhov, P.; Khorn, P.; Kuzmichev, P.; Baleeva, N.; Motov, V.; Bogorodskiy, A.; Krasnova, S.; Mineev, K.; et al. Monitoring GPCR conformation with GFP-inspired dyes. iScience 2024, 27 (8), 110466. DOI: 10.1016/j.isci.2024.110466.

Raskovalov, A.; Kim, D.; Cherezov, V. ONE-GO: Direct detection of context-dependent GPCR activity. Cell Res 2024, 34 (8), 543-544. DOI: 10.1038/s41422-024-00966-9.

Kim, D.; Liu, W.; Viner, R.; Cherezov, V. Native mass spectrometry prescreening of G protein-coupled receptor complexes for cryo-EM structure determination. Structure 2024, 32 (12), 2206-2219.e2204. DOI: 10.1016/j. str.2024.10.004.

Eun Ji Chung

Patel, N.; Avery, E.; Chung, E. J. Supramolecular hydrogels for sustained extracellular vesicle delivery. MRS Communications 2024, 14 (5), 1037-1044. DOI: 10.1557/ s43579-024-00589-6.

Huang, Y.; Wang, J.; Mancino, V.; Pham, J.; O’Grady, C.; Li, H.; Jiang, K.; Chin, D.; Poon, C.; Ho, P. Y.; et al. Oral delivery of nanomedicine for genetic kidney disease. PNAS Nexus 2024, 3 (5), pgae187. DOI: 10.1093/pnasnexus/ pgae187.

Lim, S. A.; Ho, N.; Chen, S.; Chung, E. J. Natural killer cell-derived extracellular vesicles as potential antiviral nanomaterials. Advanced Healthcare Materials 2024, 13 (19), 2304186. DOI: https://doi.org/10.1002/ adhm.202304186.

Huang, Y.; Osouli, A.; Pham, J.; Mancino, V.; O’Grady, C.; Khan, T.; Chaudhuri, B.; Pastor-Soler, N. M.; Hallows, K. R.; Chung, E. J. Investigation of basolateral targeting micelles for drug delivery applications in polycystic kidney disease. Biomacromolecules 2024, 25 (5), 2749-2761. DOI: 10.1021/acs.biomac.3c01397.

Trac, N.; Chen, Z.; Oh, H. S.; Jones, L.; Huang, Y.; Giblin, J.; Gross, M.; Sta Maria, N. S.; Jacobs, R. E.; Chung, E. J. MRI detection of lymph node metastasis through molecular targeting of C-C Chemokine Receptor Type 2 and monocyte hitchhiking. ACS Nano 2024, 18 (3), 2091-2104. DOI: 10.1021/acsnano.3c09201.

Suzuki, I.; Xing, H.; Giblin, J.; Ashraf, A.; Chung, E. J. Nanoparticle-based therapeutic strategies for mitochondrial dysfunction in cardiovascular disease. J Biomed Mater Res A 2024, 112 (6), 895-913. DOI: 10.1002/jbm.a.37668.

Francesco Cutrale

Parra, A.; Denkova, D.; Burgos-Artizzu, X. P.; Aroca, E.; Casals, M.; Godeau, A.; Ares, M.; Ferrer-Vaquer, A.; Massafret, O.; Oliver-Vila, I.; et al. METAPHOR: Metabolic evaluation through phasor-based hyperspectral imaging and organelle recognition for mouse blastocysts and oocytes. Proc Natl Acad Sci U S A 2024, 121 (28), e2315043121. DOI: 10.1073/pnas.2315043121.

Moh El-Naggar

Che, T.; Varga, B.; Bernhard, S. M.; El Daibani, A.; Zaidi, S.; Lam, J.; Aguilar, J.; Appourchaux, K.; Nazarova, A.; Kouvelis, A.; et al. Structure-guided design of partial agonists at an opioid receptor. Res Sq 2024. DOI: 10.21203/ rs.3.rs-4664764/v1.

Yang, T.; Chavez, M. S.; Niman, C. M.; Xu, S.; El-Naggar, M. Y. Long-distance electron transport in multicellular freshwater cable bacteria. Elife 2024, 12. DOI: 10.7554/ eLife.91097.

Zhao, F.; Niman, C. M.; Ostovar, G.; Chavez, M. S.; Atkinson, J. T.; Bonis, B. M.; Gralnick, J. A.; El-Naggar, M. Y.; Boedicker, J. Q. Red-light-induced genetic system for control of extracellular electron transfer. ACS Synth Biol 2024, 13 (5), 1467-1476. DOI: 10.1021/acssynbio.3c00684.

Stacey Finley

Mangrum, D. S.; Finley, S. D. Modeling the heterogeneous apoptotic response of caspase-mediated signaling in tumor cells. J Theor Biol 2024, 590, 111857. DOI: 10.1016/j. jtbi.2024.111857.Tangella, N.; Cess, C. G.; Ildefonso, G. V.; Finley, S. D. Integrating mechanism-based T cell phenotypes into a model of tumor-immune cell interactions. APL Bioeng 2024, 8 (3), 036111. DOI: 10.1063/5.0205996.

Gelbach, P. E.; Cetin, H.; Finley, S. D. Flux sampling in genome-scale metabolic modeling of microbial communities. BMC Bioinformatics 2024, 25 (1), 45. DOI: 10.1186/s12859-024-05655-3.

Nogalska, A.; Eerdeng, J.; Akre, S.; Vergel-Rodriguez, M.; Lee, Y.; Bramlett, C.; Chowdhury, A. Y.; Wang, B.; Cess, C. G.; Finley, S. D.; et al. Age-associated imbalance in immune cell regeneration varies across individuals and arises from a distinct subset of stem cells. Cell Mol Immunol 2024. DOI: 10.1038/s41423-024-01225-y.

Sheen, J.; Curtin, L.; Finley, S.D.; Konstorum, A.; McGee, R.; Craig, M. Integrating diversity, equity, and inclusion into preclinical, clinical, and public health mathematical models. Bulletin of Mathematical Biology 2024, 86, 56. DOI: 10.1007/s11538-024-01282-4.

Tserunyan, V.; Finley, S.D. Information-Theoretic Analysis of a model of CAR-4-1BB-mediated NFκB activation. Bulletin of Mathematical Biology 2023, 86, 5. DOI: 10.1007/s11538-023-01232-6.

Valery Fokin

Grotsch, K.; Sadybekov, A. V.; Hiller, S.; Zaidi, S.; Eremin, D.; Le, A.; Liu, Y.; Smith, E. C.; Illiopoulis-Tsoutsouvas, C.; Thomas, J.; et al. Virtual screening of a chemically diverse “superscaffold” library enables ligand discovery for a key GPCR target. ACS Chem Biol 2024, 19 (4), 866-874. DOI: 10.1021/acschembio.3c00602.

Judd, K. D.; Parsons, S. W.; Eremin, D. B.; Fokin, V. V.; Dawlaty, J. M. Visualizing partial solvation at the airwater interface. Chem Sci 2024, 15 (22), 8346-8354. DOI: 10.1039/d4sc01311e.

Aggarwal, S.; Vu, A.; Eremin, D. B.; Persaud, R.; Fokin, V. V. Arenes participate in 1,3-dipolar cycloaddition with in situ-generated diazoalkenes. Nat Chem 2023, 15 (6), 764772. DOI: 10.1038/s41557-023-01188-z.

Aggarwal, S.; Richards, W. J.; Fokin, V. V. Generation and aerobic oxidation of azavinyl captodative radicals. J Am Chem Soc 2023. DOI: 10.1021/jacs.3c06068.

Dawlaty, J. M.; Majumder, T.; Eremin, D. B.; Delibas, B.; Sarkar, A.; Fokin, V.V. Calibrating the oxidative capacity of microdroplets. Angew Chem Int Ed Engl 2024, e202414746. DOI: 10.1002/anie.202414746.

Peter Foster

Alam, S.; Najma, B.; Singh, A.; Laprade, J.; Gajeshwar, G.; Yevick, H. G.; Baskaran, A.; Foster, P. J.; Duclos, G. Active Fréedericksz transition in active nematic droplets. Physical Review X 2024, 14 (4), 041002. DOI: 10.1103/ PhysRevX.14.041002.

Najma, B.; Wei, W. S.; Baskaran, A.; Foster, P. J.; Duclos, G. Microscopic interactions control a structural transition in active mixtures of microtubules and molecular motors. Proc Natl Acad Sci U S A 2024, 121 (2), e2300174121. DOI: 10.1073/pnas.2300174121.

Scott E. Fraser

Parra, A.; Denkova, D.; Burgos-Artizzu, X. P.; Aroca, E.; Casals, M.; Godeau, A.; Ares, M.; Ferrer-Vaquer, A.; Massafret, O.; Oliver-Vila, I.; et al. METAPHOR: Metabolic evaluation through phasor-based hyperspectral imaging and organelle recognition for mouse blastocysts and oocytes. Proc Natl Acad Sci U S A 2024, 121 (28), e2315043121. DOI: 10.1073/pnas.2315043121.

Luu, P.; Fraser, S. E.; Schneider, F. More than double the fun with two-photon excitation microscopy. Commun Biol 2024, 7 (1), 364. DOI: 10.1038/s42003-024-06057-0.

Luu, P.; Nadtochiy, A.; Zanon, M.; Moreno, N.; Messina, A.; Petrazzini, M. E. M.; Torres Perez, J. V.; KeomaneeDizon, K.; Jones, M.; Brennan, C. H.; et al. Neural basis of number sense in larval zebrafish. bioRxiv 2024. DOI: 10.1101/2024.08.30.610552.

Zhou, H.; Li, I.; Bramlett, C. S.; Wang, B.; Hao, J.; Yen, D. P.; Ando, Y.; Fraser, S. E.; Lu, R.; Shen, K. Label-free metabolic optical biomarkers track stem cell fate transition in real time. Sci Adv 2024, 10 (19), eadi6770. DOI: 10.1126/sciadv.adi6770.

Winter, C. M.; Szekely, P.; Popov, V.; Belcher, H.; Carter, R.; Jones, M.; Fraser, S. E.; Truong, T. V.; Benfey, P. N. SHR and SCR coordinate root patterning and growth early in the cell cycle. Nature 2024, 626 (7999), 611-616. DOI: 10.1038/s41586-023-06971-z.

Frei, M. S.; Sanchez, S. A.; Liu, L.; Schneider, F.; Wang, Z.; Hakozaki, H.; Li, Y.; Lyons, A. C.; Rohm, T. V.; Olefsky, J. M.; et al. Far-red chemigenetic biosensors for multidimensional and super-resolved kinase activity imaging. bioRxiv 2024. DOI: 10.1101/2024.02.10.579766.

Pollalis, D.; Calle, A. G.; Martinez-Camarillo, J. C.; Ahluwalia, K.; Hinman, C.; Mitra, D.; Lebkowski, J.; Lee, S. Y.; Thomas, B. B.; Ahmed, F.; et al. Scaling up polarized RPE cell supernatant production on parylene membrane. Exp Eye Res 2024, 240, 109789. DOI: 10.1016/j. exer.2024.109789.

Barekatain, M.; Liu, Y.; Archambeau, A.; Cherezov, V.; Fraser, S.; White, K. L.; Hayes, M. A. Insulator-based dielectrophoresis-assisted separation of insulin secretory vesicles. Elife 2024, 13. DOI: 10.7554/eLife.74989

Cornelius Gati

Yadav, R.; Gati, C. Packaging monoamine neurotransmitters. Cell Res 2024, 34 (3), 185-186. DOI: 10.1038/s41422-023-00922-z.

Posa, L.; Romano, G.; Ji, X.; Khan, S.; Paz, B. M.; Han, G. W.; Nazarova, A. L.; Zaidi, S. A.; Ranjbar, M.; Pleil, K.; et al. An opioid efficacy switch for reversible optical control of peripheral analgesia. bioRxiv 2025. DOI: 10.1101/2024.12.16.628735.

Justin Haldar

Kung, H. T.; Cui, S. X.; Kaplan, J. T.; Joshi, A. A.; Leahy, R. M.; Nayak, K. S.; Haldar, J. P. Diffusion tensor brain imaging at 0.55T: A feasibility study. Magn Reson Med 2024, 92 (4), 1649-1657. DOI: 10.1002/mrm.30156.

Wang, J.; An, D.; Haldar, J. P. The “hidden noise” problem in MR image reconstruction. Magnetic resonance in medicine 2024, 92 (3), 982-996. DOI: 10.1002/mrm.30100.

James Hicks

Sirivolu, S.; Schmidt, M. J.; Prabakar, R. K.; Kuhn, P.; Hicks, J.; Berry, J. L.; Xu, L. Single-cell somatic copy number alteration profiling of vitreous humor seeds in retinoblastoma. Ophthalmic Genet 2024, 1-4. DOI: 10.1080/13816810.2024.2374886.

Schmidt, M. J.; Naghdloo, A.; Prabakar, R. K.; Kamal, M.; Cadaneanu, R.; Garraway, I. P.; Lewis, M.; Aparicio, A.; Zurita-Saavedra, A.; Corn, P.; et al. Polyploid cancer cells reveal signatures of chemotherapy resistance. bioRxiv 2024, 2024.2008.2019.608632. DOI: 10.1101/2024.08.19.608632.

Prabakar, R. K.; Schmidt, M. J.; Kuhn, P.; Hicks, J. GeTMoR: Simultaneous genomic, transcriptomic, and morphological profiling of rare single cells. bioRxiv 2024, 2024.2009.2029.615279. DOI: 10.1101/2024.09.29.615279

Khalil Iskarous

Coleman, J.; Krishnamachari, B.; Khalil, I.; Rosales, R. LLM-Assisted rule based machine translation for low/noresource languages. Cornell University Library, arXiv.org: Ithaca, 2024.

Rehan Kapadia

Ahsan, R.; Wu, Z.; Jalal, S. A. A.; Kapadia, R. Ultralow power electronic analog of a biological Fitzhugh-Nagumo neuron. ACS Omega 2024, 9 (16), 18062-18071. DOI: 10.1021/acsomega.3c09936.

Ahsan, R.; Chae, H. U.; Jalal, S. A. A.; Wu, Z.; Tao, J.; Das, S.; Liu, H.; Wu, J. B.; Cronin, S. B.; Wang, H.; et al. Ultralow power in-sensor neuronal computing with oscillatory retinal neurons for frequency-multiplexed, parallel machine vision. ACS Nano 2024, 18 (34), 2378523796. DOI: 10.1021/acsnano.4c09055.

Chae, H. U.; Shrewsbury, B.; Ahsan, R.; Povinelli, M. L.; Kapadia, R. GaAs mid-IR electrically tunable metasurfaces. Nano Lett 2024, 24 (8), 2581-2588. DOI: 10.1021/acs. nanolett.3c04687.

Chae, H. U.; Wu, Z.; Yu, Y.; Kim, H. g.; Sanchez Vazquez, J.; Lee, C.-H.; Yu, M.; Kapadia, R. Monolithic growth of Patternable III–V on LiNbO3. Crystal growth & design 2024, 24 (11), 4466-4472. DOI: 10.1021/cs.cgd.4c00116.

Hokyo, H.; Ito, K.; Kalia, R. K.; Kapadia, R.; Nakano, A.; Shimamura, K.; Shimojo, F.; Vashishta, P. Photoinduced negative differential resistance at a graphene/silicon interface: a nonadiabatic quantum molecular dynamics study. J Phys Chem Lett 2024, 15 (36), 9226-9232. DOI: 10.1021/acs.jpclett.4c02272.

Zhao, B.; Chen, H.; Ahsan, R.; Hou, F.; Hoglund, E. R.; Singh, S.; Shanmugasundaram, M.; Zhao, H.; Krayev, A. V.; Htoon, H.; et al. Photoconductive effects in single crystals of BaZrS3. ACS Photonics 2024, 11 (3), 1109-1116. DOI: 10.1021/acsphotonics.3c01563.

Vsevolod Katritch

Souza-Silva, I. M.; Peluso, A. A.; Mortensen, C.; Nazarova, A. L.; Stage, T. B.; Sumners, C.; Katritch, V.; Steckelings, U. M. Development of an automated, high-throughput assay to detect angiotensin AT. Peptides 2024, 172, 171137. DOI: 10.1016/j.peptides.2023.171137.

Shin, J.; Park, J.; Jeong, J.; Lam, J. H.; Qiu, X.; Wu, D.; Kim, K.; Lee, J. Y.; Robinson, C. V.; Hyun, J.; et al. Constitutive activation mechanism of a class C GPCR. Nat Struct Mol Biol 2024, 31 (4), 678-687. DOI: 10.1038/ s41594-024-01224-7.

Rao, S.; Sadybekov, A.; DeWitt, D. C.; Lipka, J.; Katritch, V.; Herring, B. E. Detection of autism spectrum disorderrelated pathogenic trio variants by a novel structure-based approach. Mol Autism 2024, 15 (1), 12. DOI: 10.1186/ s13229-024-00590-9.

Nikas, S. P.; Ji, L.; Liu, Y.; Georgiadis, M. O.; Dopeshwarkar, A.; Straiker, A.; Kudalkar, S.; Sadybekov, A. V.; Dvorakova, M.; Katritch, V.; et al. Chiral Me-2arachidonoyl Glycerols: The first potent endocannabinoid glyceride templates with stability to COX-2. ACS Med Chem Lett 2024, 15 (6), 965-971. DOI: 10.1021/ acsmedchemlett.4c00175.

Lam, J. H.; Nakano, A.; Katritch, V. Scalable computation of anisotropic vibrations for large macromolecular assemblies. Nat Commun 2024, 15 (1), 3479. DOI: 10.1038/ s41467-024-47685-8.

Havel, V.; Kruegel, A. C.; Bechand, B.; McIntosh, S.; Stallings, L.; Hodges, A.; Wulf, M. G.; Nelson, M.; Hunkele, A.; Ansonoff, M.; et al. Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models. Nat Commun 2024, 15 (1), 8118. DOI: 10.1038/s41467-02451856-y.

Grotsch, K.; Sadybekov, A. V.; Hiller, S.; Zaidi, S.; Eremin, D.; Le, A.; Liu, Y.; Smith, E. C.; Illiopoulis-Tsoutsouvas, C.; Thomas, J.; et al. Virtual screening of a chemically diverse “superscaffold” library enables ligand discovery for a key GPCR target. ACS Chem Biol 2024, 19 (4), 866-874. DOI: 10.1021/acschembio.3c00602.

Deshpande, D.; Chhugani, K.; Ramesh, T.; Pellegrini, M.; Shiffman, S.; Abedalthagafi, M. S.; Alqahtani, S.; Ye, J.; Liu, X. S.; Leek, J. T.; et al. The evolution of computational research in a data-centric world. Cell 2024, 187 (17), 44494457. DOI: 10.1016/j.cell.2024.07.045.

Che, T.; Varga, B.; Bernhard, S. M.; El Daibani, A.; Zaidi, S.; Lam, J.; Aguilar, J.; Appourchaux, K.; Nazarova, A.; Kouvelis, A.; et al. Structure-guided design of partial agonists at an opioid receptor. Res Sq 2024. DOI: 10.21203/ rs.3.rs-4664764/v1.

Arroyo-Urea, S.; Nazarova, A. L.; Carrión-Antolí, Á.; Bonifazi, A.; Battiti, F. O.; Lam, J. H.; Newman, A. H.; Katritch, V.; García-Nafría, J. A bitopic agonist bound to the dopamine 3 receptor reveals a selectivity site. Nat Commun 2024, 15 (1), 7759. DOI: 10.1038/s41467-024-51993-4.

Steve Kay

Heller, H. C.; Herzog, E.; Brager, A.; Poe, G.; Allada, R.; Scheer, F.; Carskadon, M.; de la Iglesia, H. O.; Jang, R.; Montero, A.; et al. The negative effects of travel on student athletes through sleep and circadian disruption. J Biol Rhythms 2024, 39 (1), 5-19. DOI: 10.1177/07487304231207330.

Liang, T.; Yu, S.; Pan, Y.; Wang, J.; Kay, S. A. The interplay between the circadian clock and abiotic stress responses mediated by ABF3 and CCA1/LHY. Proc Natl Acad Sci U S A 2024, 121 (7), e2316825121. DOI: 10.1073/ pnas.2316825121.

Martínez-Vasallo, C.; Cole, B.; Pérez-Alemany, J.; OrtizRamírez, C. I.; Gallego-Bartolomé, J.; Chory, J.; Kay, S. A.; Nohales, M. A. GIGANTEA adjusts the response to shade at dusk by directly impinging on

Phytochrome Interacting Factor 7 function. Proc Natl Acad Sci U S A 2024, 121 (30), e2315778121. DOI: 10.1073/ pnas.2315778121.

Porco, S.; Yu, S.; Liang, T.; Snoeck, C.; Hermans, C.; Kay, S. A. The clock-associated LUX ARRHYTHMO regulates high-affinity nitrate transport in Arabidopsis roots. Plant J 2024. DOI: 10.1111/tpj.17080.

Chan, P.; Nagai, Y.; Wu, Q.; Hovsepyan, A.; Mkhitaryan, S.; Wang, J.; Karapetyan, G.; Kamenecka, T.; Solt, L. A.; Cope, J.; et al. Advancing clinical response against glioblastoma: evaluating SHP1705 CRY2 activator efficacy in preclinical models and safety in Phase I trials. bioRxiv 2024. DOI: 10.1101/2024.09.17.613520.

Pan, Y.; Chiu, T. P.; Zhou, L.; Chan, P.; Kuo, T. T.; Battaglin, F.; Soni, S.; Jayachandran, P.; Li, J. J.; Lenz, H. J.; et al. Targeting circadian transcriptional programs through a cis-regulatory mechanism in triple negative breast cancer. bioRxiv 2024. DOI: 10.1101/2024.04.26.590360.

Carl Kesselman

Schuler, R.; Kesselman, C. Creating thriving datacentric communities from basic research to commercial applications. In 2024 IEEE 20th International Conference on e-Science (e-Science), 16-20 Sept. 2024, 2024; pp 1-3. DOI: 10.1109/e-Science62913.2024.10678730.

Nguyen, V.; Iyengar, S.; Rasheed, H.; Apolo, G.; Li, Z.; Kumar, A.; Nguyen, H.; Bohner, A.; Dhodapkar, R.; Do, J.; et al. Expert-level detection of referable glaucoma from fundus photographs in a safety net population: the AI and teleophthalmology in Los Angeles initiative. medRxiv 2024, 2024.2008.2025.24312563. DOI: 10.1101/2024.08.25.24312563.

Li, Z.; Kesselman, C.; D’Arcy, M.; Pazzani, M.; Xu, B. Y. Deriva-ML: A continuous FAIRness approach to reproducible machine learning models. In 2024 IEEE 20th International Conference on e-Science (e-Science), 16-20 Sept. 2024, 2024; pp 1-10. DOI: 10.1109/e-Science62913.2024.10678671.

Rasheed, H.; Iyengar, S.; Nguyen, V.; Li, Z.; Kumar, A.; Lee, A.; Duong, A.; Wong, B.; Gluckstein, J.; Hong, K.; et al. Development and validation of a deep learning algorithm to automate detection of referable glaucoma in a safety net teleretinal program. Investigative Ophthalmology & Visual Science 2024, 65 (7), 372-372. (acccessed 10/31/2024).

Vallat, B.; Webb, B. M.; Westbrook, J. D.; Goddard, T. D.; Hanke, C. A.; Graziadei, A.; Peisach, E.; Zalevsky, A.; Sagendorf, J.; Tangmunarunkit, H.; et al. IHMCIF: An extension of the PDBx/mmCIF data standard for integrative structure determination methods. J Mol Biol 2024, 436 (17), 168546. DOI: 10.1016/j.jmb.2024.168546.

Mercedeh Khajavikhan

Luo, H.; Wei, Y.; Pyrialakos, G. G.; Khajavikhan, M.; Christodoulides, D. N. Guiding charged particles in vacuum via Lagrange points. Nat Commun 2024, 15 (1), 6882. DOI: 10.1038/s41467-024-51083-5.

Luo, H.; Wei, Y.; Pyrialakos, G. G.; Khajavikhan, M.; Christodoulides, D. N. Publisher correction: guiding charged particles in vacuum via Lagrange points. Nat Commun 2024, 15 (1), 7944. DOI: 10.1038/s41467-024-52420-4.

Liu, Y. G. N.; Lee, J.; Khajavikhan, M. Coupled distributed feedback laser system at 820 nm for THz beat-frequency generation. Optics letters 2024, 49 (15), 4274. DOI: 10.1364/OL.530574.

Yasser Khan

Abdigazy, A.; Arfan, M.; Shao, J.; Islam, M. S.; Hassan, M. F.; Khan, Y. 3D gas mapping in the gut with AI-enabled ingestible and wearable electronics. Cell Reports Physical Science 2024, 5 (7). DOI: 10.1016/j.xcrp.2024.101990 (acccessed 2024/11/01).

Khan, Y.; Mauriello, M. L.; Nowruzi, P.; Motani, A.; Hon, G.; Vitale, N.; Li, J.; Kim, J.; Foudeh, A.; Duvio, D.; et al. On stress: combining human factors and biosignals to inform the placement and design of a skin-like stress sensor. In Proceedings of the 2024 CHI Conference on Human Factors in Computing Systems, Honolulu, HI, USA; 2024.

Abdigazy, A.; Arfan, M.; Lazzi, G.; Sideris, C.; Abramson, A.; Khan, Y. End-to-end design of ingestible electronics. Nature Electronics 2024, 7 (2), 102-118. DOI: 10.1038/ s41928-024-01122-2.

Peter Kuhn

Bagheri, P.; Eremina, O. E.; Fernando, A.; Kamal, M.; Stegis, I.; Vazquez, C.; Shishido, S. N.; Kuhn, P.; Zavaleta, C. A systematic approach toward enabling maximal targeting efficiency of cell surface proteins with actively targeted SERS nanoparticles. ACS Appl Mater Interfaces 2024, 16 (13), 15847-15860. DOI: 10.1021/acsami.3c18959.

Bai, L.; Courcoubetis, G.; Mason, J.; Hicks, J. B.; Nieva, J.; Kuhn, P.; Shishido, S. N. Longitudinal tracking of circulating rare events in the liquid biopsy of stage III-IV non-small cell lung cancer patients. Discov Oncol 2024, 15 (1), 142. DOI: 10.1007/s12672-024-00984-4.

Clarke, C. A.; Mitchell, B. L.; Putcha, G.; Alme, E.; Bach, P.; Beer, J. P.; Beer, T. M.; Beidelschies, M. A.; Hoyos, J.; Klein, E.; et al. Lexicon for blood-based early detection and screening: BLOODPAC consensus document. Clin Transl Sci 2024, 17 (9), e70016. DOI: 10.1111/cts.70016.

Dorff, T. B.; Blanchard, M. S.; Adkins, L. N.; Luebbert, L.; Leggett, N.; Shishido, S. N.; Macias, A.; Del Real, M. M.; Dhapola, G.; Egelston, C.; et al. PSCA-CAR T cell therapy in metastatic castration-resistant prostate cancer: a phase 1 trial. Nat Med 2024, 30 (6), 1636-1644. DOI: 10.1038/ s41591-024-02979-8.

Ghoreifi, A.; Shishido, S. N.; Sayeed, S.; Courcoubetis, G.; Huang, A.; Schuckman, A.; Aron, M.; Desai, M.; Daneshmand, S.; Gill, I. S.; et al. Blood-based liquid biopsy: A promising noninvasive test in diagnosis, surveillance, and prognosis of patients with upper tract urothelial carcinoma. Urol Oncol 2024, 42 (4), 118.e119-118.e117. DOI: 10.1016/j.urolonc.2024.02.001.

Resnick, K.; Shah, A.; Mason, J.; Kuhn, P.; Nieva, J.; Shishido, S. N. Circulation of rare events in the liquid biopsy for early detection of lung mass lesions. Thorac Cancer 2024, 15 (29), 2100-2109. DOI: 10.1111/17597714.15429.

Shishido, S. N.; Lin, E.; Nissen, N.; Courcoubetis, G.; Suresh, D.; Mason, J.; Osipov, A.; Hendifar, A. E.; Lewis, M.; Gaddam, S.; et al. Cancer-related cells and oncosomes in the liquid biopsy of pancreatic cancer patients undergoing surgery. NPJ Precis Oncol 2024, 8 (1), 36. DOI: 10.1038/ s41698-024-00521-0.

Shishido, S. N.; Hart, O.; Jeong, S.; Moriarty, A.; Heeke, D.; Rossi, J.; Bot, A.; Kuhn, P. Liquid biopsy approach to monitor the efficacy and response to CAR-T cell therapy. J Immunother Cancer 2024, 12 (2). DOI: 10.1136/jitc-2023007329.

Sirivolu, S.; Schmidt, M. J.; Prabakar, R. K.; Kuhn, P.; Hicks, J.; Berry, J. L.; Xu, L. Single-cell somatic copy number alteration profiling of vitreous humor seeds in retinoblastoma. Ophthalmic Genet 2024, 1-4. DOI: 10.1080/13816810.2024.2374886.

Shishido, S. N.; Suresh, D.; Courcoubetis, G.; Ye, B.; Lin, E.; Mason, J.; Park, K.; Lewis, M.; Wang, R.; Lo, S. K.; et al. Determining the efficacy of ExThera Seraph100 blood filtration in patients diagnosed with pancreatic cancer through the liquid biopsy. BJC Reports 2024, 2 (1), 47. DOI: 10.1038/s44276-024-00069-3.

Schmidt, M. J.; Naghdloo, A.; Prabakar, R. K.; Kamal, M.; Cadaneanu, R.; Garraway, I. P.; Lewis, M.; Aparicio, A.; Zurita-Saavedra, A.; Corn, P.; et al. Polyploid cancer cells reveal signatures of chemotherapy resistance. bioRxiv 2024, 2024.2008.2019.608632. DOI: 10.1101/2024.08.19.608632.

Prabakar, R. K.; Schmidt, M. J.; Kuhn, P.; Hicks, J. GeTMoR: Simultaneous genomic, transcriptomic, and morphological profiling of rare single cells. bioRxiv 2024, 2024.2009.2029.615279. DOI: 10.1101/2024.09.29.615279

Gianluca Lazzi

Morales, A. W.; Du, J.; Iseri, E.; Lazzi, G. AI in bioelectromagnetics for the assessment of safety and neurorestoration strategies during electrical stimulation therapies. In 2024 IEEE-APS Topical Conference on Antennas and Propagation in Wireless Communications (APWC), 2-6 Sept. 2024, 2024; pp 1-1. DOI: 10.1109/ APWC61918.2024.10701924.

Nguyen, T. D.; Maggi, A.; Lazzi, G.; Sideris, C. A 12 V compliant multichannel dual mode neural stimulator with 0.004% charge mismatch and a 4×VDD tolerant on-chip discharge switch in low-voltage CMOS. IEEE SolidState Circuits Letters 2024, 7, 283-286. DOI: 10.1109/ LSSC.2024.3467341.

Iseri, E.; Nguyen, T. D.; Sideris, C.; Gokoffski, K. K.; Lazzi, G. Improving stimulation tolerance for implantable neurostimulators through enhanced capacitive conduction. In 2024 IEEE INC-USNC-URSI Radio Science Meeting (Joint with AP-S Symposium), 14-19 July 2024, 2024; pp 412-412. DOI: 10.23919/INC-USNCURSI61303.2024.10632503.

Lazzi, G. Bioelectromagnetics for the treatment of neurodegenerative conditions - is there hope? In memory of W. Ross Stone. In 2024 IEEE INC-USNC-URSI Radio Science Meeting (Joint with AP-S Symposium), 14-19 July 2024, 2024; pp 220-220. DOI: 10.23919/INC-USNCURSI61303.2024.10632415.

Pahlavan, P.; Iseri, E.; Ghiam, B. K.; Silliman, T.; Huang, C.; Cavaleri, J.; Lee, D. J.; Gokoffski, K. K.; Lazzi, G. Generating electric fields along the human optic nerve to promote axonal regeneration. In 2024 IEEE INCUSNC-URSI Radio Science Meeting (Joint with AP-S Symposium), 14-19 July 2024, 2024; pp 402-402. DOI: 10.23919/INC-USNC-URSI61303.2024.10632338.

Niu, G.; Silliman, T.; Simonyan, A.; Pahavan, P.; Lazzi, G.; Gokoffski, K. K. Electric fields direct growth of human embryonic stem cell-derived retinal ganglion cell axons in vitro. Investigative Ophthalmology & Visual Science 2024, 65 (7), 953-953. (acccessed 11/1/2024).

Lu, A.; Ebright, B.; Naik, A.; Tan, H. L.; Cohen, N. A.; Bouteiller, J. C.; Lazzi, G.; Louie, S. G.; Humayun, M. S.; Asante, I. Hydroxypropyl-Beta Cyclodextrin barrier prevents respiratory viral infections: A Preclinical Study. Int J Mol Sci 2024, 25 (4). DOI: 10.3390/ijms25042061.

Morales, A. W.; Du, J.; Warren, D. J.; Fernández-Jover, E.; Martinez-Navarrete, G.; Bouteiller, J. C.; McCreery, D. C.; Lazzi, G. Machine learning enables non-Gaussian investigation of changes to peripheral nerves related to electrical stimulation. Sci Rep 2024, 14 (1), 2795. DOI: 10.1038/s41598-024-53284-w.

Abdigazy, A.; Arfan, M.; Lazzi, G.; Sideris, C.; Abramson, A.; Khan, Y. End-to-end design of ingestible electronics. Nature Electronics 2024, 7 (2), 102-118. DOI: 10.1038/ s41928-024-01122-2.

Jeremy Mason

Bai, L.; Courcoubetis, G.; Mason, J.; Hicks, J. B.; Nieva, J.; Kuhn, P.; Shishido, S. N. Longitudinal tracking of circulating rare events in the liquid biopsy of stage III-IV non-small cell lung cancer patients. Discov Oncol 2024, 15 (1), 142. DOI: 10.1007/s12672-024-00984-4.

Ghoreifi, A.; Shishido, S. N.; Sayeed, S.; Courcoubetis, G.; Huang, A.; Schuckman, A.; Aron, M.; Desai, M.; Daneshmand, S.; Gill, I. S.; et al. Blood-based liquid biopsy: a promising noninvasive test in diagnosis, surveillance, and prognosis of patients with upper tract urothelial carcinoma. Urol Oncol 2024, 42 (4), 118.e119-118.e117. DOI: 10.1016/j.urolonc.2024.02.001.

Mahmoodifar, S.; Pangal, D. J.; Neman, J.; Zada, G.; Mason, J.; Salhia, B.; Kaisman-Elbaz, T.; Peker, S.; Samanci, Y.; Hamel, A.; et al. Comparative analysis of the spatial distribution of brain metastases across several primary cancers using machine learning and deep learning models. J Neurooncol 2024, 167 (3), 501-508. DOI: 10.1007/s11060-024-04630-5.

Resnick, K.; Shah, A.; Mason, J.; Kuhn, P.; Nieva, J.; Shishido, S. N. Circulation of rare events in the liquid biopsy for early detection of lung mass lesions. Thorac Cancer 2024, 15 (29), 2100-2109. DOI: 10.1111/17597714.15429.

Shishido, S. N.; Lin, E.; Nissen, N.; Courcoubetis, G.; Suresh, D.; Mason, J.; Osipov, A.; Hendifar, A. E.; Lewis, M.; Gaddam, S.; et al. Cancer-related cells and oncosomes in the liquid biopsy of pancreatic cancer patients undergoing surgery. NPJ Precis Oncol 2024, 8 (1), 36. DOI: 10.1038/ s41698-024-00521-0.

Alexander McDowell

Practices for Futurecasting, contributing Chapter, UNESCO, Publ. October 2024.

Charles McKenna

Alnajjar, K. S.; Wang, K.; Alvarado-Cruz, I.; Chavira, C.; Negahbani, A.; Nakhjiri, M.; Minard, C.; Garcia-Barboza, B.; Kashemirov, B. A.; McKenna, C. E.; et al. Modifying the basicity of the dNTP leaving group modulates precatalytic conformational changes of DNA polymerase β. Biochemistry 2024, 63 (11), 1412-1422. DOI: 10.1021/acs. biochem.4c00065.

Seebald, L. M.; Haratipour, P.; Jacobs, M. R.; Bernstein, H. M.; Kashemirov, B. A.; McKenna, C. E.; Imperiali, B. Uridine bisphosphonates differentiate phosphoglycosyl transferase superfamilies. J Am Chem Soc 2024, 146 (5), 3220-3229. DOI: 10.1021/jacs.3c11402.

Shi, B. Y.; Sriram, V.; Wu, S. Y.; Huang, D.; Cheney, A.; Metzger, M. F.; Sundberg, O.; Lyons, K. M.; McKenna, C. E.; Nishimura, I.; et al. Novel bisphosphonate-based cathepsin K-triggered compound targets the enthesis without impairing soft tissue-to-bone healing. Front Bioeng Biotechnol 2024, 12, 1308161. DOI: 10.3389/ fbioe.2024.1308161.

Tollefson, A. E.; Riemann, S. B.; Ying, B.; Spencer, J. F.; Overhulse, J. M.; Kashemirov, B. A.; Wold, W. S. M.; McKenna, C. E.; Toth, K. Oral USC-093, a novel homoserinamide analogue of the tyrosinamide (S)-HPMPA prodrug USC-087 has decreased nephrotoxicity while maintaining antiviral efficacy against human adenovirus infection of Syrian hamsters. Antiviral Res 2024, 222, 105799. DOI: 10.1016/j.antiviral.2024.105799.

Ellis Meng

Sands, I.; Demarco, R.; Thurber, L.; Esteban‐Linares, A.; Song, D.; Meng, E.; Chen, Y. Interface‐mediated neurogenic signaling: the impact of surface geometry and chemistry on neural cell behavior for regenerative and brain–machine interfacing applications. Advanced materials (Weinheim) 2024, 36 (33), e2401750-n/a. DOI: 10.1002/ adma.202401750.

Shrikanth Narayanan

Adeboye, O.; Cooke, G.; White, K.; Tate, S.; Zafonte, R.; Narayanan, S.; Mehl, M.; Shin, M.; Dhand, A. Abstract

TP14: SocialBit: a novel smartwatch sensor to detect social interaction frequency in stroke survivors. Stroke 2024, 55 (Suppl_1), ATP14-ATP14. DOI: doi:10.1161/str.55.suppl_1.

TP14. Ashvin, A.;

Lahiri, R.; Kommineni, A.; Bishop, S.; Lord, C.; Kadiri, S. R.; Narayanan, S. Evaluation of state-of-the-art ASR models in child-adult interactions. arXiv preprint arXiv:2409.16135 2024.

Booth, B. M.; Narayanan, S. S. People make mistakes: otaining accurate ground truth from continuous annotations of subjective constructs. Behavior Research Methods 2024, 56 (8), 8784-8800. DOI: 10.3758/s13428-024-02503-3.

Cabrera, A.; Avramidis, K.; Narayanan, S. Early detection of coffee leaf rust through convolutional neural networks trained on low-resolution images. arXiv preprint arXiv:2407.14737 2024.

Chang, M. Y.; Heidary, G.; Beres, S.; Pineles, S. L.; Gaier, E. D.; Gise, R.; Reid, M.; Avramidis, K.; Rostami, M.; Narayanan, S. Artificial intelligence to differentiate pediatric pseudopapilledema and true papilledema on fundus photographs. Ophthalmology Science 2024, 4 (4), 100496. DOI: https://doi.org/10.1016/j.xops.2024.100496.

Chang, M.; Avramidis, K.; Sharma, R.; Borchert, M.; Narayanan, S. Saliency analysis of eye tracking in children with cortical/cerebral visual impairment (CVI) enabled by machine learning. Investigative Ophthalmology & Visual Science 2024, 65 (7), 1501-1501.

Chochlakis, G.; Potamianos, A.; Lerman, K.; Narayanan, S. Aggregation artifacts in subjective tasks collapse large language models’ posteriors. arXiv preprint arXiv:2410.13776 2024.

Chochlakis, G.; Potamianos, A.; Lerman, K.; Narayanan, S. The strong pull of prior knowledge in large language models and its impact on emotion recognition. arXiv preprint arXiv:2403.17125 2024.

Feng, T.; Dimitriadis, D.; Narayanan, S. Can synthetic audio from generative foundation models assist audio recognition and speech modeling? arXiv preprint arXiv:2406.08800 2024.

Feng, T.; Zhang, T.; Avestimehr, S.; Narayanan, S. ModalityMirror: Improving audio classification in modality heterogeneity federated learning with multimodal distillation. arXiv preprint arXiv:2408.15803 2024.

Kommineni, A.; Bose, D.; Feng, T.; Kim, S. H.; TagerFlusberg, H.; Bishop, S.; Lord, C.; Kadiri, S.; Narayanan, S. Towards child-inclusive clinical video understanding for autism spectrum disorder. arXiv preprint arXiv:2409.13606 2024.

Kuo, P. B.; Tanana, M. J.; Goldberg, S. B.; Caperton, D. D.; Narayanan, S.; Atkins, D. C.; Imel, Z. E. Machine-learningbased prediction of client distress from session recordings. Clinical Psychological Science 2024, 12 (3), 435-446. DOI: 10.1177/21677026231172694.

Laukkanen, A.-M.; Kadiri, S. R.; Narayanan, S.; Alku, P. Can a machine distinguish high and low amount of social creak in speech? Journal of Voice 2024. DOI: https://doi. org/10.1016/j.jvoice.2024.09.050.

Lee, J.; Kommineni, A.; Feng, T.; Avramidis, K.; Shi, X.; Kadiri, S.; Narayanan, S. Toward fully-end-to-end listened speech decoding from EEG Signals. arXiv preprint arXiv:2406.08644 2024.

Nguyen, H.; Foley, S.; Huang, K.; Shi, X.; Feng, T.; Narayanan, S. Speech2rtMRI: speech-guided diffusion model for real-time MRI video of the vocal tract during speech. arXiv preprint arXiv:2409.15525 2024.

Oh, M.; Byrd, D.; Goldstein, L.; Narayanan, S. Vertical larynx actions and intergestural timing stability in Hausa ejectives and implosives. 2024. DOI: doi:10.1515/phon2023-0052

Xu, A.; Feng, T.; Tager-Flusberg, H.; Lord, C.; Narayanan, S. Data efficient child-adult speaker diarization with simulated conversations. arXiv preprint arXiv:2409.08881 2024.

Xu, A.; Huang, K.; Feng, T.; Shen, L.; Tager-Flusberg, H.; Narayanan, S. Exploring speech foundation models for speaker diarization in child-adult dyadic interactions. arXiv preprint arXiv:2406.07890 2024.

Zhang, T.; Feng, T.; Ni, Y.; Cao, M.; Liu, R.; Butler, K.; Weng, Y.; Zhang, M.; Narayanan, S..; Avestimehr, S. Creating a lens of Chinese culture: a multimodal dataset for Chinese pun rebus art understanding. arXiv preprint arXiv:2406.10318 2024.

Krishna Nayak

Brandhorst, S.; Levine, M. E.; Wei, M.; Shelehchi, M.; Morgan, T. E.; Nayak, K. S.; Dorff, T.; Hong, K.; Crimmins, E. M.; Cohen, P.; et al. Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk. Nat Commun 2024, 15 (1), 1309. DOI: 10.1038/s41467-024-45260-9.

Campbell-Washburn, A. E.; Varghese, J.; Nayak, K. S.; Ramasawmy, R.; Simonetti, O. P. Cardiac MRI at low field strengths. J Magn Reson Imaging 2024, 59 (2), 412-430. DOI: 10.1002/jmri.28890.

Keenan, K. E.; Tasdelen, B.; Javed, A.; Ramasawmy, R.; Rizzo, R.; Martin, M. N.; Stupic, K. F.; Seiberlich, N.; Campbell-Washburn, A. E.; Nayak, K. S. T1 and T2 measurements across multiple 0.55T MRI systems using open-source vendor-neutral sequences. Magn Reson Med 2025, 93 (1), 289-300. DOI: 10.1002/mrm.30281.

Kung, H. T.; Cui, S. X.; Kaplan, J. T.; Joshi, A. A.; Leahy, R. M.; Nayak, K. S.; Haldar, J. P. Diffusion tensor brain imaging at 0.55T: a feasibility study. Magn Reson Med 2024, 92 (4), 1649-1657. DOI: 10.1002/mrm.30156.

Lee, N. G.; Bauman, G.; Bieri, O.; Nayak, K. S. Replication of the bSTAR sequence and open-source implementation. Magn Reson Med 2024, 91 (4), 1464-1477. DOI: 10.1002/ mrm.29947.

Lim, Y.; Kumar, P.; Nayak, K. S. Speech production realtime MRI at 0.55 T. Magn Reson Med 2024, 91 (1), 337343. DOI: 10.1002/mrm.29843.

Qin, Q.; Alsop, D. C.; Bolar, D. S.; Hernandez-Garcia, L.; Meakin, J.; Liu, D.; Nayak, K. S.; Schmid, S.; van Osch, M. J. P.; Wong, E. C.; et al. Erratum to: Velocity-selective arterial spin labeling perfusion MRI: a review of the state of the art and recommendations for clinical implementation (Magn Reson Med. 2022; 88:1528-1547). Magn Reson Med 2024, 92 (2), 881. DOI: 10.1002/mrm.30099.

Shih, S. F.; Tasdelen, B.; Yagiz, E.; Zhang, Z.; Zhong, X.; Cui, S. X.; Nayak, K. S.; Wu, H. H. Improved liver fat and R2* quantification at 0.55 T using locally lowrank denoising. Magn Reson Med 2024. DOI: 10.1002/ mrm.30324.

Tasdelen, B.; Lee, N. G.; Cui, S. X.; Nayak, K. S. Improved abdominal T1 weighted imaging at 0.55T. Magn Reson Med 2024, 92 (6), 2580-2587. DOI: 10.1002/mrm.30224.

Tian, Y.; Nayak, K. S. New clinical opportunities of lowfield MRI: heart, lung, body, and musculoskeletal. MAGMA 2024, 37 (1), 1-14. DOI: 10.1007/s10334-023-01123-w.

Tian, Y.; Nayak, K. S. Real-time water/fat imaging at 0.55T with spiral out-in-out-in sampling. Magn Reson Med 2024, 91 (2), 649-659. DOI: 10.1002/mrm.29885.

Toews, A. R.; Lee, P. K.; Nayak, K. S.; Hargreaves, B. A. Comprehensive assessment of nonuniform image quality: application to imaging near metal. Magn Reson Med 2024, 92 (6), 2358-2372. DOI: 10.1002/mrm.30222.

Zhao, Z.; Lee, N. G.; Nayak, K. S. Multidimensional RF pulse design with consideration of concomitant field effects. Magn Reson Med 2024. DOI: 10.1002/mrm.30311.

Niema Pahlevan

Alavi, R.; Dai, W.; Mazandarani, S. P.; Arechavala, R. J.; Herman, D. A.; Kleinman, M. T.; Kloner, R. A.; Pahlevan, N. M. Adverse cardiovascular effects of nicotine delivered by chronic electronic cigarettes or standard cigarettes captured by cardiovascular intrinsic frequencies. J Am Heart Assoc 2024, 13 (18), e035462. DOI: 10.1161/ JAHA.124.035462.

Alavi, R.; Mazandarani Sohrab, P.; Dai, W.; Arechavala, R.; Herman, D.; Kleinman, M.; Kloner Robert, A.; Pahlevan Niema, M. Detection of adverse effects of chronic e-cigarette and standard cigarette on ventricular and arterial functions in rats using intrinsic frequencies of carotid pressure waveforms. Journal of the American College of Cardiology 2024, 83 (13_Supplement), 1809-1809. DOI: 10.1016/S0735-1097(24)03799-9.

Liu, J.; Bilgi, C.; Bregasi, A.; Mitchell, G. F.; Pahlevan, N. M. Noninvasive left ventricle pressure-volume loop determination method with cardiac magnetic resonance imaging and carotid tonometry using a physics-informed approach. IEEE Journal of Biomedical and Health Informatics 2024, 28 (9), 5487-5496. DOI: 10.1109/ JBHI.2024.3412671.

Jin, W.; Rinderknecht, D.; Chiu, W. B.; Krupa, A.; Jerdonek, C.; Cook, K. R.; Pahlevan, N. M. Incorporating intrathoracic pressure fluctuation can improve noninvasive prediction of left ventricular end-diastolic pressure. European Heart Journal 2024, 45 (Supplement_1). DOI: 10.1093/eurheartj/ ehae666.3541.

Pahlevan, N. M.; Alavi, R.; Liu, J.; Ramos, M.; Hindoyan, A.; Matthews, R. V. Detecting elevated left ventricular end diastolic pressure from simultaneously measured femoral pressure waveform and electrocardiogram. Physiol Meas 2024, 45 (8). DOI: 10.1088/1361-6579/ad69fd.

Vaidya, A.; Niroumandi, S.; Mazandarani Sohrab, P.; Wolfson, A.; Pahlevan Niema, M. Left ventricle pulsatile workload from a single pressure waveform using physicsbased machine learning approach and cardiovascular disease events in the Framingham Heart Study. Journal of the American College of Cardiology 2024, 83 (13_Supplement), 2451-2451. DOI: 10.1016/S0735-1097(24)04441-3.

Vaidya, A.; Niroumandi, S.; Mazandarani Sohrab, P.; Wolfson, A.; Pahlevan Niema, M. Prognostic value of aortic characteristic impedance calculated from a single carotid waveform using hybrid intrinsic frequency-machine learning approach. Journal of the American College of Cardiology 2024, 83 (13_Supplement), 1988-1988. DOI: 10.1016/S0735-1097(24)03978-0.

Vaidya, A.; Niroumandi, S.; Mazandarani Sohrab, P.; Wolfson, A.; Pahlevan Niema, M. Single pressure waveform calculation of total arterial compliance predict heart failure events in Framingham Heart Study. Journal of the American College of Cardiology 2024, 83 (13_Supplement), 712-712. DOI: 10.1016/S0735-1097(24)02702-5.

Zhou, L.; Rafiei, D.; Mogadam, E.; Alavi, R.; Pahlevan Niema, M.; Mehra Anilkumar, O. Indirect ballistic injury resulting in shockwave-induced NSTEMI. Journal of the American College of Cardiology 2024, 83 (13_Supplement), 3394-3394. DOI: 10.1016/S0735-1097(24)05384-1.

Matthew Robert Pratt

Balana, A. T.; Mahul-Mellier, A. L.; Nguyen, B. A.; Horvath, M.; Javed, A.; Hard, E. R.; Jasiqi, Y.; Singh, P.; Afrin, S.; Pedretti, R.; et al. Author Correction: O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nat Chem Biol 2024, 20 (5), 656. DOI: 10.1038/s41589-024-01587-4.

Balana, A. T.; Mahul-Mellier, A. L.; Nguyen, B. A.; Horvath, M.; Javed, A.; Hard, E. R.; Jasiqi, Y.; Singh, P.; Afrin, S.; Pedretti, R.; et al. O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nat Chem Biol 2024, 20 (5), 646-655. DOI: 10.1038/s41589-024-01551-2.

Javed, A.; Johnson, O. T.; Balana, A. T.; Volk, R. F.; Langen, A.; Ahn, B. S.; Zaro, B. W.; Gestwicki, J. E.; Pratt, M. R. O-GlcNAc modification of HSP27 alters its protein interactions and promotes refolding of proteins through the BAG3/HSP70 co-chaperone. Protein Sci 2024, 33 (10), e5173. DOI: 10.1002/pro.5173.

Liu, S.; Daley, E. J.; Tran, L. M.; Yu, Z.; Reyes, M.; Dean, T.; Khatri, A.; Levine, P. M.; Balana, A. T.; Pratt, M. R.; et al. Backbone modification provides a long-acting inverse agonist of pathogenic, constitutively active PTH1R variants. J Am Chem Soc 2024, 146 (10), 6522-6529. DOI: 10.1021/ jacs.3c09694.

Morales, M. M.; Pratt, M. R. The post-translational modification O-GlcNAc is a sensor and regulator of metabolism. Open Biol 2024, 14 (10), 240209. DOI: 10.1098/rsob.240209.

Pratt, M. R.; Prescher, J. A. Carolyn Bertozzi: Building new bonds between molecules, fields, and communities. Cell Chem Biol 2024, 31 (8), 1383-1385. DOI: 10.1016/j. chembiol.2024.07.015.

Wang, B.; Pratt, M. R. Potential for targeting small heat shock protein modifications. Trends Pharmacol Sci 2024, 45 (7), 583-585. DOI: 10.1016/j.tips.2024.04.002.

Ishwar K. Puri

Datta, P.; Moolayadukkam, S.; Prasad Sahu, R.; Ganguly, R.; Sen, S.; Puri, I. K. Deciphering the hydrodynamics of lipid-coated microbubble sonoluminescence for sonodynamic therapy. Ultrason Sonochem 2024, 111, 107090. DOI:10.1016/j.ultsonch.2024.107090.

Datta, P.; Moolayadukkam, S.; Chowdhury, D.; Rayes, A.; Lee, N. S.; Sahu, R. P.; Zhou, Q.; Puri, I. K. Recent advances and future directions in sonodynamic therapy for cancer treatment. BME Frontiers 0 (ja) 2024. DOI: doi:10.34133/bmef.0080.

Datta, P.; Lee, N. S.; Moolayadukkam, S.; Sahu, R. P.; Yu, X.; Guo, T.; Zhou, Q.; Wang, Y.; Puri, I. K. In vitro sonodynamic therapy using a high throughput 3d glioblastoma spheroid model with 5-ALA and TMZ sonosensitizers. Advanced Healthcare Materials n/a (n/a), 2402877. 2024. DOI: https://doi.org/10.1002/ adhm.202402877.

Jayakanth Ravichandran

Balakrishnan, P. P.; Ferenc Segedin, D.; Chow, L. E.; Quarterman, P.; Muramoto, S.; Surendran, M.; Patel, R. K.; LaBollita, H.; Pan, G. A.; Song, Q.; et al. Extensive hydrogen incorporation is not necessary for superconductivity in topotactically reduced nickelates. Nature Communications 2024, 15 (1), 7387. DOI: 10.1038/ s41467-024-51479-3.

Chen, H.; Liu, Y.; Kumarasubramanian, H.; Surendran, M.; Ravichandran, J. A strategy for fabricating microscale freestanding single-crystalline complex oxide device arrays. ACS Applied Electronic Materials 2024. DOI: 10.1021/ acsaelm.4c01480.

Chen, H.; Ravichandran, J. A system built for both deterministic transfer processes and contact photolithography. Advanced Engineering Materials 2024, 26 (20), 2401228. DOI: https://doi.org/10.1002/ adem.202401228.

Chen, H.; Singh, S.; Mei, H.; Ren, G.; Zhao, B.; Surendran, M.; Wang, Y.-T.; Mishra, R.; Kats, M. A.; Ravichandran, J. Molten flux growth of single crystals of quasi-1D hexagonal chalcogenide BaTiS3. Journal of Materials Research 2024, 39 (13), 1901-1910. DOI: 10.1557/s43578-024-01379-5.

Humphrey, N.; Tsung, A.; Singh, S.; Irshad, A.; Zhao, B.; Narayan, S.; Ravichandran, J.; Mallikarjun Sharada, S. The hydrogen evolution activity of BaZrS3, BaTiS3, and BaVS3 chalcogenide perovskites. ChemPhysChem 2024, 25 (13), e202300953. DOI: https://doi.org/10.1002/cphc.202300953.

Surendran, M.; Singh, S.; Chen, H.; Wu, C.; Avishai, A.; Shao, Y.-T.; Ravichandran, J. A hybrid pulsed laser deposition approach to grow thin films of chalcogenides. Advanced Materials 2024, 36 (19), 2312620. DOI: https:// doi.org/10.1002/adma.202312620.

Surendran, M.; Rollag, J. R.; Stevens, C. E.; Fu, C.T.; Kumarasubramanian, H.; Wang, Z.; Schlom, D. G.; Gibson, R.; Hendrickson, J. R.; Ravichandran, J. Epitaxial rare-earth-doped complex oxide thin films for infrared applications. ACS Applied Electronic Materials 2024, 6 (5), 3539-3544. DOI: 10.1021/acsaelm.4c00303.

Ye, K.; Menahem, M.; Salzillo, T.; Knoop, F.; Zhao, B.; Niu, S.; Hellman, O.; Ravichandran, J.; Jaramillo, R.; Yaffe, O. Differing vibrational properties of halide and chalcogenide perovskite semiconductors and impact on optoelectronic performance. Physical Review Materials 2024, 8 (8), 085402. DOI: 10.1103/PhysRevMaterials.8.085402.

Yu, R.; Shrewsbury, B. K.; Wu, C.; Kumarasubramanian, H.; Surendran, M.; Ravichandran, J.; Povinelli, M. L. Growth of VO2-ZnS thin film cavity for adaptive thermal emission. Applied Physics Letters 2024, 125 (12). DOI: 10.1063/5.0222653

Zhao, B.; Ren, G.; Mei, H.; Wu, V. C.; Singh, S.; Jung, G. Y.; Chen, H.; Giovine, R.; Niu, S.; Thind, A. S.; et al. Giant modulation of refractive index from picoscale atomic displacements. Advanced Materials 2024, 36 (24), 2311559. DOI: https://doi.org/10.1002/adma.202311559.

Zhao, B.; Chen, H.; Ahsan, R.; Hou, F.; Hoglund, E. R.; Singh, S.; Shanmugasundaram, M.; Zhao, H.; Krayev, A. V.; Htoon, H.; et al. Photoconductive effects in single crystals of BaZrS3. ACS photonics 2024, 11 (3), 1109-1116. DOI: 10.1021/acsphotonics.3c01563.

Remo Rohs

Bonnell, V. A.; Zhang, Y.; Brown, A. S.; Horton, J.; Josling, G. A.; Chiu, T. P.; Rohs, R.; Mahony, S.; Gordân, R.; Llinás, M. DNA sequence and chromatin differentiate sequencespecific transcription factor binding in the human malaria parasite Plasmodium falciparum. Nucleic Acids Res 2024, 52 (17), 10161-10179. DOI: 10.1093/nar/gkae585.

Jiang, Y.; Chiu, T. P.; Mitra, R.; Rohs, R. Probing the role of the protonation state of a minor groove-linker histidine in Exd-Hox-DNA binding. Biophys J 2024, 123 (2), 248-259. DOI: 10.1016/j.bpj.2023.12.013.

Li, J.; Rohs, R. Deep DNAshape webserver: prediction and real-time visualization of DNA shape considering extended k-mers. Nucleic Acids Res 2024, 52 (W1), W7-W12. DOI: 10.1093/nar/gkae433.

Li, J.; Chiu, T. P.; Rohs, R. Predicting DNA structure using a deep learning method. Nat Commun 2024, 15 (1), 1243. DOI: 10.1038/s41467-024-45191-5.

Mitra, R.; Cohen, A. S.; Sagendorf, J. M.; Berman, H. M.; Rohs, R. DNAproDB: an updated database for the automated and interactive analysis of protein-DNA complexes. Nucleic Acids Res 2024. DOI: 10.1093/nar/ gkae970.

Mitra, R.; Li, J.; Sagendorf, J. M.; Jiang, Y.; Cohen, A. S.; Chiu, T. P.; Glasscock, C. J.; Rohs, R. Geometric deep learning of protein-DNA binding specificity. Nat Methods 2024, 21 (9), 1674-1683. DOI: 10.1038/s41592-02402372-w.

Mitra, R.; Cohen, A. S.; Rohs, R. RNAscape: geometric mapping and customizable visualization of RNA structure. Nucleic Acids Res 2024, 52 (W1), W354-W361. DOI: 10.1093/nar/gkae269.

Sagendorf, J. M.; Mitra, R.; Huang, J.; Chen, X. S.; Rohs, R. Structure-based prediction of protein-nucleic acid binding using graph neural networks. Biophys Rev 2024, 16 (3), 297-314. DOI: 10.1007/s12551-024-01201-w.

Mitra, R.; Huang, J.; Chen, X. S.; Rohs, R. Structure-based prediction of protein-nucleic acid binding using graph neural networks. Biophys Rev 2024, 16 (3), 297-314. DOI: 10.1007/s12551-024-01201-w.

Weller, J. A.; Rohs, R. Structure-based drug design with a deep hierarchical generative model. J Chem Inf Model 2024, 64 (16), 6450-6463. DOI: 10.1021/acs.jcim.4c01193.

Maryam Shanechi

Sani, O. G.; Pesaran, B.; Shanechi, M. M. Dissociative and prioritized modeling of behaviorally relevant neural dynamics using recurrent neural networks. Nat Neurosci 2024, 27 (10), 2033-2045. DOI: 10.1038/s41593-02401731-2.

Andrew Steen

Rosengard, S. Z.; Moura, J. M. S.; Spencer, R. G. M.; Johnson, C.; McNichol, A.; Steen, A. D.; Galy, V. Depthpartitioning of particulate organic carbon composition in the rising and falling stages of the Amazon River. Geochemistry, Geophysics, Geosystems 2024, 25 (6), e2023GC011273. DOI: https://doi.org/10.1029/2023GC011273.

Ruff, S. E.; Hrabe de Angelis, I.; Mullis, M.; Payet, J. P.; Magnabosco, C.; Lloyd, K. G.; Sheik, C. S.; Steen, A. D.; Shipunova, A.; Morozov, A.; et al. A global atlas of subsurface microbiomes reveals phylogenetic novelty, large scale biodiversity gradients, and a marine-terrestrial divide. bioRxiv 2024, 2024.2004.2029.591682. DOI: 10.1101/2024.04.29.591682.

Shore Selene, F. H.; Ptacek, M.; Steen Andrew, D.; Fozo Elizabeth, M. A simple BLASTn-based approach generates novel insights into the regulation and biological function of type I toxin-antitoxins. mSystems 2024, 9 (7), e0120401223. DOI: 10.1128/msystems.01204-23.

Sipes, K.; Buongiorno, J.; Steen, A. D.; Abramov, A. A.; Abuah, C.; Peters, S. L.; Gianonne, R. J.; Hettich, R. L.; Boike, J.; Garcia, S. L.; et al. Depth-specific distribution of bacterial MAGs in permafrost active layer in Ny Ålesund, Svalbard (79 N). Systematic and Applied Microbiology 2024, 47 (6), 126544. DOI: https://doi.org/10.1016/j. syapm.2024.126544.

Coon, G. R.; Williams, L.; Matthews, A.; Diaz, R.; Kevorkian, R. T.; LaRowe, D.; Steen, A. D.; Lapham, L.; Lloyd, K. G. Control of hydrogen concentrations by microbial sulfate reduction in two contrasting anoxic coastal sediments. Frontiers in Microbiology 2024, 15, Original Research. DOI: 10.3389/fmicb.2024.1455857.

Terry Takahashi

Haas, S. S.; Ge, R.; Agartz, I.; Amminger, G. P.; Andreassen, O. A.; Bachman, P.; Baeza, I.; Choi, S.; Colibazzi, T.; Cropley, V. L.; et al. Normative modeling of brain morphometry in clinical high risk for psychosis. JAMA Psychiatry 2024, 81 (1), 77-88. DOI: 10.1001/ jamapsychiatry.2023.3850.

Hirayama, K.; Takahashi, T.; Yan, X.; Koga, T.; Osu, R. Somatosensory stimulation on the wrist enhances the subsequent hand-choice by biasing toward the stimulated hand. Sci Rep 2024, 14 (1), 22726. DOI: 10.1038/s41598024-73245-7.

Zhu, Y.; Maikusa, N.; Radua, J.; Sämann, P. G.; FusarPoli, P.; Agartz, I.; Andreassen, O. A.; Bachman, P.; Baeza, I.; Chen, X.; et al. Using brain structural neuroimaging measures to predict psychosis onset for individuals at clinical high-risk. Mol Psychiatry 2024, 29 (5), 1465-1477. DOI: 10.1038/s41380-024-02426-7.

Ye Tian

Yagiz, E.; Garg, P.; Cen, S. Y.; Nayak, K. S.; Tian, Y. Simultaneous multi-slice cardiac real-time MRI at 0.55T. Magn Reson Med 2024. DOI: 10.1002/mrm.30364.

Boudreau, M.; Karakuzu, A.; Cohen-Adad, J.; Bozkurt, E.; Carr, M.; Castellaro, M.; Concha, L.; Doneva, M.; Dual, S. A.; Ensworth, A.; et al. Repeat it without me: crowdsourcing the T. Magn Reson Med 2024, 92 (3), 1115-1127. DOI: 10.1002/mrm.30111.

Amerom, J. v.; Tian, Y.; Goolaub, D.; Wood, J.; Detterich, J.; Nayak, K.; Macgowan, C. Fetal cardiac 3D cine imaging at 0.55T - whole heart slice-to-volume reconstruction from real-time spiral MRI. Journal of Cardiovascular Magnetic Resonance 2024, 26. DOI: 10.1016/j.jocmr.2024.101012.

Goolaub, D. S.; Tian, Y.; Amerom, J. v.; Wood, J.; Detterich, J.; Nayak, K.; Macgowan, C. Multiresolution comparison of fetal CINE MRI at 0.55T. Journal of Cardiovascular Magnetic Resonance 2024, 26. DOI: 10.1016/j. jocmr.2024.100104.

Tian, Y.; Nayak, K. S. New clinical opportunities of lowfield MRI: heart, lung, body, and musculoskeletal. MAGMA 2024, 37 (1), 1-14. DOI: 10.1007/s10334-023-01123-w.

Tian, Y.; Nayak, K. S. Real-time water/fat imaging at 0.55T with spiral out-in-out-in sampling. Magn Reson Med 2024, 91 (2), 649-659. DOI: 10.1002/mrm.29885.

Vitouš, J.; Jiřík, R.; Stračina, T.; Hendrych, M.; Nádeníček, J.; Macíček, O.; Tian, Y.; Krátká, L.; Dražanová, E.; Nováková, M.; et al. T1 mapping of myocardium in rats using self-gated golden-angle acquisition. Magn Reson Med 2024, 91 (1), 368-380. DOI: 10.1002/mrm.29846.

Jordanova, K. V.; Fraenza, C. C.; Martin, M. N.; Tian, Y.; Shen, S.; Vaughn, C. E.; Walsh, K. J.; Walsh, C.; Sappo, C. R.; Ogier, S. E.; et al. Paramagnetic salt and agarose recipes for phantoms with desired T1 and T2 values for low-field MRI. NMR Biomed 2025, 38 (1), e5281. DOI: 10.1002/ nbm.5281.

Jennifer Treweek

Eliahoo, P.; Setayesh, H.; Hoffman, T.; Wu, Y.; Li, S.; Treweek, J. B. Viscoelasticity in 3D cell culture and regenerative medicine: measurement techniques and biological relevance. ACS Mater Au 2024, 4 (4), 354-384. DOI: 10.1021/acsmaterialsau.3c00038.

Peter Yingxiao Wang

Tang, M.; Qu, Y.; He, P.; Yao, E.; Guo, T.; Yu, D.; Zhang, N.; Kiratitanaporn, W.; Sun, Y.; Liu, L.; et al. Heatinducible CAR-T overcomes adverse mechanical tumor microenvironment in a 3D bioprinted glioblastoma model. Materials Today Bio 2024, 26, 101077. DOI: https://doi. org/10.1016/j.mtbio.2024.101077.

Zhu, L.; Man, C.-W.; Harrison, R. E. S.; Wu, Z.; Limsakul, P.; Peng, Q.; Hashimoto, M.; Mamaril, A. P.; Xu, H.; Liu, L.; et al. Engineering a Programmed Death-Ligand 1-targeting monobody via directed evolution for synnotchgated cell therapy. ACS Nano 2024, 18 (11), 8531-8545. DOI: 10.1021/acsnano.4c01597.

Kate White

Li, W.; Li, A.; Yu, B.; Zhang, X.; Liu, X.; White, K. L.; Stevens, R. C.; Baumeister, W.; Sali, A.; Jasnin, M.; et al. In situ structure of actin remodeling during glucose-stimulated insulin secretion using cryo-electron tomography. Nat Commun 2024, 15 (1), 1311. DOI: 10.1038/s41467-02445648-7.

Deshmukh, A.; Chang, K.; Cuala, J.; Vanslembrouck, B.; Georgia, S.; Loconte, V.; White, K. L. Subcellular feature-based classification of α and β cells using soft X-ray tomography. Cells 2024, 13 (10). DOI: 10.3390/ cells13100869.

Barekatain, M.; Liu, Y.; Archambeau, A.; Cherezov, V.; Fraser, S.; White, K. L.; Hayes, M. A. Insulator-based dielectrophoresis-assisted separation of insulin secretory vesicles. Elife 2024, 13. DOI: 10.7554/eLife.74989.

Cristina Zavaleta

Aron, A.; Zavaleta, C. Current and developing lymphatic imaging approaches for elucidation of functional mechanisms and disease progression. Mol Imaging Biol 2024, 26 (1), 1-16. DOI: 10.1007/s11307-023-01827-4.

Bagheri, P.; Eremina, O. E.; Fernando, A.; Kamal, M.; Stegis, I.; Vazquez, C.; Shishido, S. N.; Kuhn, P.; Zavaleta, C. A systematic approach toward enabling maximal targeting efficiency of cell surface proteins with actively targeted SERS nanoparticles. ACS Appl Mater Interfaces 2024, 16 (13), 15847-15860. DOI: 10.1021/acsami.3c18959.

Czaja, A.; Jiang, A. J.; Blanco, M. Z.; Eremina, O. E.; Zavaleta, C. A Raman topography imaging method toward assisting surgical tumor resection. NPJ Imaging 2024, 2 (1), 2. DOI: 10.1038/s44303-024-00006-6.

Czaja, A.; Awad, S.; Eremina, O. E.; Fernando, A.; Zavaleta, C. Assessment of unmixing approaches for the quantitation of SERS nanoparticles in highly multiplexed spectral images. Journal of Raman Spectroscopy 2024, 55 (5), 566580. DOI: https://doi.org/10.1002/jrs.6653.

Eremina, O. E.; Vazquez, C.; Larson, K. N.; Mouchawar, A.; Fernando, A.; Zavaleta, C. The evolution of immune profiling: will there be a role for nanoparticles? Nanoscale Horiz 2024. DOI: 10.1039/d4nh00279b.

Wade Zeno

Bouzos, N.; Zeno, W. F. Membrane fission by clathrin. Biophysical Journal 2024, 123 (3), 92a. DOI: 10.1016/j. bpj.2023.11.677.

Johnson, D. H.; Kou, O. H.; Bouzos, N.; Zeno, W. F. Protein-membrane interactions: sensing and generating curvature. Trends Biochem Sci 2024, 49 (5), 401-416. DOI: 10.1016/j.tibs.2024.02.005.

Johnson, D. H.; Zeno, W. F. Synergy between the structured and disordered regions of alpha-synuclein in membrane remodeling. Biophysical Journal 2024, 123 (3), 74a. DOI: 10.1016/j.bpj.2023.11.523.

Kim, J.; Johnson, D. H.; Bharucha, T. S.; Yoo, J. M.; Zeno, W. F. Graphene quantum dots inhibit lipid peroxidation in biological membranes. ACS Appl Bio Mater 2024, 7 (8), 5597-5608. DOI: 10.1021/acsabm.4c00688.

Kou, O. H.; Johnson, D. H.; Zeno, W. F. Influence of membrane physiochemical properties on dynamic binding interactions with alpha-synuclein. Biophysical Journal 2024, 123 (3), 371a. DOI: 10.1016/j.bpj.2023.11.2262.

Pizarro Carbajal, B. S.; Zeno, W. F. Characterizing synthetic cell penetrating nanodiscs for therapeutic delivery. Biophysical Journal 2024, 123 (3), 558a. DOI: 10.1016/j. bpj.2023.11.3377.

Appendix

An overview of faculty productivity: measuring impact, innovation, and scholarly achievements.

In This Section

120 Faculty Overview & Collaborations

FACULTY OVERVIEW & COLLABORATIONS

This section highlights the significant contributions of Michelson Faculty in advancing knowledge, driving innovation, and fostering academic excellence. It provides a comprehensive look at faculty research output, publications, grants, and collaborative efforts, showcasing the impact of their work on both the academic community and beyond. By recognizing their achievements, we celebrate the dedication and expertise of Michelson Faculty, whose efforts continue to shape the future of research and education.

Note

The Profile and Network Charts on the following pages exclude publications with more than 25 authors, as well as non-USC collaborators, with the exception of Drs. Peter Foster and Helen Berman, as their affiliations in the Dimensions database are still associated with their previous research institution, prior to joining USC. Data and graphics from Dimensions database and platform, part of Digital Science.

“ Once you took the first step, anything was possible. — Katherine Johnson
Kandis Leslie Abdul-Aziz

Richard Brutchey
Dani Byrd
Vadim Cherezov

Francesco Cutrale
Moh El-Naggar
Stacey Finley

Fokin

Valery
Peter Foster

Cornelius Gati
Justin Haldar
James Hicks
Rehan Kapadia

Steve Kay

Mercedeh
Yasser Khan

Gianluca Lazzi

Jeremy

Charles McKenna

Ellis Meng
Shrikanth Narayanan

Niema Pahlevan

Ishwar K. Puri

Jennifer Treweek

Kate White
Cristina Zavaleta
Wade Zeno

USC MICHELSON CENTER FOR CONVERGENT BIOSCIENCE

We thank Araceli Roach for the layout, graphic arts and design, Amy Wood for information gathering, as well as creating the Appendix tables and charts, and Michael Yarsky for proofreading.

Silvia da Costa, Ph.D. Director, Research Initiatives and Infrastructure Editor and Scientific Writer

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