K01 Grants
renal cell carcinoma patients. My long-term career goals include pursing additional NIH funding as an independent investigator and lead a multi-disciplinary team in advancing data-driven medicine. In doing so, I hope to inspire future scientists to pursue challenges in biomedical data science and guide them in the same tradition of mentorship that is being given to me. Public Health Relevance: There currently exists a critical, unmet need to improve methods of selecting effective therapy for advanced kidney cancer, the most lethal of urologic cancers. The proposed mentored career development award will focus on identifying molecular markers of treatment success by developing an informatics toolkit that incorporates molecular data into a large, well-annotated institutional database of patients with advanced kidney cancer. The scientific findings of this grant will be used to identify the most effective treatment based on individual tumor biology and accelerate discovery in the molecular biology of kidney cancer. Address; Adoption; base; Big Data; Binding (Molecular Function); Bioinformatics; Biological Assay; Biology; Biometry; cancer care; cancer therapy; career; Caring; Characteristics; Clinical; Clinical Data; Clinical Sciences; Clinical Trials; clinically relevant; Collaborations; companion diagnostics; Computer software; Computers; Data; data exchange; data management; database query; Databases; Decision Making; design; Development; Disease; Education; effective therapy; exome; Exons; flexibility; Funding; Future; Gene Expression Profile; genome-wide; Genomics; Goals; Grant; Healthcare; Human; Imagery; Immune response; immunogenic; Immunotherapy; improved; Individual; Informatics; inhibitor/antagonist; K-Series Research Career Programs; Knowledge; Lead; Link; Malignant neoplasm of prostate; Malignant Neoplasms; Medical; Medicine; Mentors; Mentorship; Methods; methylome; Molecular; Molecular Analysis; Molecular Biology; molecular marker; mTOR Inhibitor; Oncologist; oncology; Online Systems; Operative Surgical Procedures; Outcome; Palate; Patient Care; Patients; Peptides; Pharmaceutical Preparations; precision medicine; protein aminoacid sequence; public health relevance; Registries; Renal carcinoma; Renal Cell Carcinoma; repository; Research; Research Infrastructure; Research Personnel; Research Project Grants; response; Risk; RNA; Sampling; Science; Scientist; skills; Specimen; success; Technology; The Cancer Genome Atlas; Time; Tissues; tool; tool development; Translating; Translational Research; Treatment outcome; treatment response; tumor; Tumor Biology; Tumor Pathology; Tumor Specific Peptide; Tyrosine Kinase Inhibitor; United States National Institutes of Health; Urologic Cancer; Urologic Oncology; Urologist; Work
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