Building for Life Campaign: Case for Support

Campaign CAS E FO R S UP PORT

The

Roslyn and Leonard Stoler

Center for Advanced Medicine HOME OF THE

TABLE OF CONTENTS EXECUTIVE SUMMARY........................................................................................................................5 OUR HISTORY.........................................................................................................................................6 MEETING TODAY’S NEEDS - BUILDING FOR OUR FUTURE.................................................8 THE ROSLYN AND LEONARD STOLER CENTER FOR ADVANCED MEDICINE...........12 BEYOND THE BRICKS AND MORTAR..........................................................................................17 OUR CALL TO ACTION: INVEST IN BETTER HEALTH AND BETTER LIVES.................26

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UNIVERSITY OF MARYLAND MEDICAL SYSTEM / UNIVERSITY OF MARYLAND CANCER NETWORK

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Research Institutions

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to people who have less than we have. People with

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Our deepest wish is that we can bring some light cancer are suffering physically and mentally, and if we can help them in any way, we’re satisfied.

— Leonard and Roslyn Stoler

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EXECUTIVE SUMMARY The University of Maryland Medical System (UMMS) and University of Maryland Medical Center (UMMC) are powerful forces for good—for the hundreds of thousands of patients we treat each year, the City of Baltimore, our region, and increasingly the nation. Our premier cancer center, the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC), is dedicated to improving our patients’ lives. The half a billion dollars in research our UM School of Medicine physician-scientists conduct every year translates into advanced care for patients in Maryland and around the world.

This is the work of an academic center like UMGCCC, where clinical care, research, training, and education come together to accelerate and translate innovative discoveries into promising new treatments and therapies for our patients and their families.

To address our urgent need to expand patient care and advance critical areas of cancer research, UMGCCC is undertaking a substantial transformation—one that will create a new and enhanced building and take our clinical programs to the next level. To achieve these goals, we have launched the Building for Life Campaign to: •

Support the creation of the Roslyn and Leonard Stoler Center for Advanced Medicine, a cutting-edge facility designed to change the nature of patient care, and;

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Provide funding to advance clinical care, patient support services, research, training, and education.

The Building for Life Campaign seeks to raise over $55 million and marks a watershed moment for the institution. The reimagined Cancer Center will lift the entire UMMS enterprise and grow the capacity, quality, and renown of everything we do.

In addition, the investment from the campaign will: •

Enhance our ability to provide higher quality of care for our patients and their loved ones,

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Accelerate the development of promising treatments across our cancer specialties, and;

•

Train the next generation of cancer experts.

This effort will enhance cancer care and treatment not only at our flagship medical center, but at each of our 13 member hospitals under UMMS—ultimately changing and saving countless lives.

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Stewart and Marlene Greenebaum, provided the $10M founding gift for UMGCCC in 1996 after Mrs. Greenebaum’s successful treatment and recovery from breast cancer.

OUR HISTORY UMGCCC precursor, Baltimore Cancer Research Center (BCRC) is operated as part of a National Cancer Institue (NCI) program

1965-1972

BCRC moves to U MD campus, continues a NCI program

1970

Landmark MOPP trial for Hodgkin’s Disease published

1974-1982

University of Maryland Cancer Center (UMCC) renamed UMGCC to honor philanthropists Marlene and Stewart Greenebaum

1982

U MD Cancer Center established

1996

2001

State of Maryland Cigarette Restitution funding begins and has provided $151,000,000 in research funding to Cancer Center, through 2019 6

Drs. Angela and Harry Brodie’s invention of a class of drugs called “aromatase inhibitors” has changed the way breast cancer is treated around the world.

Angela Brodie wins Kettering Prize honoring her development of aromatase inhibitors for breast cancer treatment

Unsuccessful application for NCI designation

2002

2004

2005

Kevin Cullen, MD becomes UMGCC Director

Maryland Governor Larry Hogan treated for lymphoma at UMGCC

2008

UMGCC becomes a NCI-designated Cancer Center – renewed 2011

2015

State appropriates $125,000,000 to support construction of new tower to house UMGCCC clinical facilities. Construction scheduled 2021

2016

2019

UMGCC renews CCSG, elevated to Comprehensive status.

Name changed to UMGCCC

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MEETING TODAY’S NEEDS BUILDING FOR OUR FUTURE UMMC was established in 1823 in partnership with the nation’s first public medical school. We remain wholly committed to improving lives and lifting our community.

As the excellence of the services we provide at UMGCCC has grown, so has the demand for quality cancer care. Our patient volumes have more than tripled in the past 15 years, yet our physical space has stayed the same. In addition, we have been at the forefront of major advancements that have been made in cancer research and treatments in the past decade, but we need continued support of our research endeavors to push forward scientific discovery from the research bench to the patient bedside.

Today, as the demand for cancer care has greatly increased, our dispersed facilities have become a barrier to providing the best coordinated care.

Depending on a patient’s needs, care could be delivered in four or five locations at UMMC, requiring additional time for navigating the campus and causing additional stress. Our sense of urgency in consolidating care is accelerated by research linking higher levels of stress with worsening of the disease.

We also want to increase our support services around patient care and community outreach; recruit new talent and retain established faculty; and host advanced trainings for our physicians, nurses, and medical students. Enhancing these priorities will strengthen all of our cancer services within UMGCCC.

Black man, my experience at the UMMC has been affirming, comprehensive and lifesaving.

— Alfred Diggs, UMGCCC Community Advisory

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As a 20+ year prostate cancer survivor and

Board member 8

UMGCCC AT A GLANCE:

We have provided

Our health education

37,000+ free cancer

programs reach more than

screenings since 2001.

Research focused on improving access to care and treatment outcomes for minorities, who represent a majority

(56%)

of the patients in our clinical

218 clinical trials open

30,000 people

We treat

3,000+

new cancer patients/year

52,000+ outpatient visits/year

$105 million total cancer research funding in our most recent year

trials, compared to 2%-17% nationally.

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UMGCCC RESEARCHERS ARE MAKING A CRITICAL IMPACT ON THE FIGHT AGAINST CANCER

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Drs. Angela and Harry Brodie’s invention of a class of drugs called “aromatase inhibitors” has changed the way breast cancer is treated around the world. Aromatase inhibitors reduce death from breast cancer by nearly 40 percent in post-menopausal patients, saving the lives of hundreds of thousands of women around the world.

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UMGCCC investigators have developed new drugs for prostate and pancreatic cancer. Clinical trials underway at the center are providing new hope for patients with those diseases.

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UMGCCC has become a national leader in the emerging field of immunotherapy. Already successful in lymphoma and leukemia, new cellular therapies invented here are moving to clinical trials in myeloma and solid tumors.

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Cancer center investigators have responded to the COVID-19 pandemic, re-purposing drugs developed for leukemia and bone marrow transplantation to fight the potentially life threatening effects of COVID infection.

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innovation is demonstrated by every employee for every patient, and from every walk of life. In the terrifying and often frantic world of a cancer diagnosis, the gift of compassionate, coordinated care delivered in a state-of-the-art facility cannot be overstated. UMGCCC is not just a hospital, it’s the heart of the community and home to thousands of dedicated employees and patients in urgent need.

— Dana Deighton, Grateful Patient

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UMGCCC’s unmatched culture of compassion and

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THE ROSLYN AND LEONARD STOLER CENTER FOR ADVANCED MEDICINE The new Center will be built onto the front of our 22 South Greene Street hospital tower and main entrance, with six floors dedicated to cancer care. Further growth would accommodate additional floors on top of this new structure.

This is about changing how we care for patients and their families in their most urgent time of need. The new Center will enable us to provide an environment of healing from the moment our patients and their families walk in the door.

By consolidating UMGCCC we will integrate many cancer therapies into a single site. We will streamline each patient’s care by unlocking the ability to deliver team-based care in new ways.

We will create a new, cutting-edge facility, and accelerate our work in these areas: •

Treating Hematologic Malignancies and

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Advanced cancer diagnostic services

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Treating early and late-stage cancers

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Outpatient chemotherapy infusion

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Robust Clinical trials

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Advanced oncologic surgery

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Innovative Research protocols

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Bone Marrow Transplant and advanced

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Multi-disciplinary outpatient care

immunotherapies

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Attracting the best physicians, nurses,

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Molecular profiling

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Advanced radiation therapies

rare/complex tumors

and staff

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We will expand space devoted to UMGCCC by 50 percent. The new UMGCCC will include:

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Urgent Care Center A new Center wholly devoted to

All new outpatient clinic and infusion space designed with options that match

compromised immune systems do not

patient preference for seating, personal

have to go to a general emergency

interactions, and other therapies

room and are seen immediately by

(radiation oncology will remain in

doctors and staff who are experts in

current UMMC space)

cancer care Entrance

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and access for the building and include a healing garden for patients and their

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New technologies in patient spaces, public areas, and staff offices, that maximize efficiency and enhance experience and education

A research space dedicated for medical capabilities Inpatient Services Two new inpatient floors with amenities that include exercise facilities for

loved ones Technology

Clinical Research Space research, enabling us to expand our

A new, modern, and inviting entrance for to streamline patient check-in, security

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Outpatient Clinics

cancer patients, ensuring those with

patients and visitors will include a lobby

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patients, respite areas for families, and

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all-private accommodations Cancer Pharmacy A dedicated pharmacy for prepping and mixing chemotherapy and other medications/treatments

Bone Marrow Transplant & Immunotherapy A floor dedicated to inpatient and outpatient transplants and other novel immunotherapies 13

The new lobby/entrance at UMMC

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New additions will alleviate stress for our patients and their families throughout the treatment process. They will provide better ways to deliver cancer care by:

DEEPENING excellence in patient outcomes Incorporating new research discoveries developed by clinical researchers to promote healing, facilitate innovation, and support better processes and reduced wait times

INCREASING access to care by extending our capacity to treat patients Expanding inpatient and outpatient spaces and supporting new care, such as multiweek cell transplant therapy delivered as an outpatient treatment

EXPANDING research capabilities Investing in our discovery-based medicine, enabling us to provide the most advanced care and develop more cutting-edge treatment therapies to help people live longer

ENHANCING the integration of holistic care Co-locating and integrating clinical care professionals with team members providing services such as psychological counseling, social work and nutrition

equipment and ample spaces for amazingly talented people to produce cutting-edge research, there’s no limit to what the Center will accomplish for the benefit of Marylanders and the world beyond.

— William E. “Brit” Kirwan, PhD, Building for Life Campaign Chair

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With superb facilities for patient care, state-of-the-art

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Aaron Rapoport, MD is a professor at the UM School of Medicine and an oncologist at UMGCCC who helped pioneer T-cell immunotherapy for blood cancers 16

BEYOND THE BRICKS AND MORTAR The Building for Life Campaign creates an incredible opportunity for UMGCCC to strengthen and expand our care and research priorities.

For UMGCCC to continue its leadership role as one of the top academic medical centers and be counted among the premier institutions of medical education and research in the world, it must: •

Invigorate innovative research,

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Sustain and grow its outstanding faculty, and;

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Provide first-rate training to a continuum of cancer care providers.

In addition, UMGCCC strives to enhance the patient experience in every way possible.

A cancer diagnosis can happen to anybody despite their age and background. It is important to not only physically heal the patient, but offer services that reduce stress, ease the financial burden, and inspire emotional healing. Providing these resources helps the patient to focus on what’s most important—beating cancer.

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INVIGORATE INNOVATIVE RESEARCH Every day, we are advancing new discoveries in basic cancer biology and applying this knowledge to innovative therapies and prevention strategies for our cancer patients.

Our goal is also to ensure that clinical trial enrollments reflect the demographics of our area and that research priorities are aligned with our goals in addressing socioeconomic disparities in healthcare. We will continue our work to remedy health-outcome disparities based on race, by utilizing research that seeks to understand underlying causes of differences. Our faculty leads the nation in the number of clinical trials underway involving African Americans.

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The potential for future research is limitless, and we currently have over 200 researchers working in five specific programs at UMGCCC:

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Experimental Therapeutics: create and test new therapies for solid tumors and blood cancers. We investigate early molecular detection to guide new treatment approaches and assess the responses.

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Hormone Related Cancers: develop strategies for improving diagnosis, informing treatment, and evaluating patient responses to treatments by better understanding these types of cancers so we can reduce morbidity and mortality.

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Molecular and Structural Biology: conduct highly innovative laboratory research aimed at bringing new drugs to the clinical setting. We look for how genetic damage and instability in cancer cells can be taken advantage of, and how RNA biology and gene expression that are coopted by cancer cells to drive tumor growth, can be suppressed.

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Population Science: better identify the causes of cancer, understand cancer-related behavior and outcomes, and translate basic discovery into behavioral interventions to prevent and control cancer. We seek to identify the molecular, genetic, and lifestyle determinants related to cancers in the United States and globally, and identify the psychosocial influences impacting how cancers behave.

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Tumor Immunology and Immunotherapy: conduct highly innovative laboratory research and clinical trials focused specifically on how the body’s immune system can be used effectively to fight certain cancers.

Based on our research, we are well positioned to make a significant impact along the cancer continuum in our region and the nation in the years ahead.

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SUSTAIN AND GROW OUR OUTSTANDING FACULTY Endowed professorships are among the highest honors in an academic medical setting. Those who hold endowed professorships are nationally and internationally recognized faculty who lead significant research efforts and attract the best students who want to work with acknowledged leaders.

Endowing a professorship recognizes a professor’s extraordinary impact in their field and provides funds in perpetuity for novel education, research, and clinical care projects.

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PROVIDE FIRST-RATE TRAINING AND EDUCATION UMCCCC provides a robust pipeline of cancer-focused research and education that spans from middle-school through post-graduate training.

One of our primary missions is to integrate education and training with cuttingedge cancer research activities. Our goal is to provide first-rate cancer research training to a continuum of cancer researchers to inspire in individuals a longterm commitment to cancer.

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Fellowships: Post-doctoral fellowship are important mechanisms for supporting future leaders in medicine. Fellows are young physicians who have completed their medical education and residency and seek additional, specialized training to hone their knowledge, gain experience under the mentorship of recognized experts, and acquire the latest specialized skills and tools to diagnose, treat, and prevent illnesses. Fellows are trained to provide advanced patient care and gain research experience by participating in the conduct of clinical trials and developing research grant

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proposals.

Certifications: We encourage nurses to become Oncology Nurse Certified and give them the opportunity to design and implement various research and operations projects.

The CURE Scholars Program: Launched in 2015, the University of Maryland, Baltimore (UMB) CURE Scholars Program is a groundbreaking year-round program that seeks to empower middle school and high school students in West Baltimore for competitive and rewarding research, health care, and STEM-related career opportunities. The program hopes to inspire dedication to higher education and STEM careers that will empower the students and their community to help alleviate medical and educational disparities.

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PATIENT SUPPORT SERVICES An important focus of our work at UMGCCC has always been to ensure that the innovations and therapies created here reach all of the citizens of our community. We are proud of our proven track record of success. In this next exciting phase for UMGCCC, we want to ensure that we continue to apply discoveries and strategies to the entire Maryland community and beyond with a specific focus on cancer disparities – the differences in prevention, detection, and outcomes of various groups, based on their socio-economic status and other factors.

“Financial Toxicity” describes the effects of financial stressors on patients.

Reducing such toxicity is part of the care UMGCCC provides. Many of our patients lack the financial means to get to and from appointments, or fund portions of their care. We make every effort to provide services for our patients that they may not normally have access to during their treatment. UMGCCC’s outstanding Social Work team assesses all patients in need and works to provide them with appropriate resources in the following areas: Transportation: The average cancer patient will make over 100 visits to the cancer center during the course of their care. For those without reliable transportation we offer to arrange rides through a special discounted rate with Lyft. For those who are here daily and can’t afford the parking costs, we subsidize and discount costs.

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Prescription Drugs: Uninsured or under-insured patients without prescription insurance are vulnerable to lapses in care. While we do everything possible to find drug manufacturer assistance programs to provide free drugs, when possible, there are many patients in need who are not be able to take advantage of such opportunities. Our partnership with the UMMC pharmacy can source drugs at the lowest price thanks to donor funds.

Emergency Stabilization: Some patients require help covering the cost of their basic needs such as a month of rent, a utility payment, filling their tank with gas, or a meal. It is important to have funds onhand to help cover some of these short-term stabilization needs.

Hotel/Lodging: While our partnership with the American Cancer Society’s Hope Lodge in Baltimore has served many patients over the years with overnight lodging, their capacity can be limited at times. A patient or their family member may need a night or two at a local hotel before beginning treatment. Funds to cover this are important to give a patient a strong start to their care.

Social Workers: The Social Work team managing access for all of the resources outlined above can be stretched thin because the patient need is more than we can resource. Expanding this team on a permanent basis would serve the community and the patients of Baltimore in the manner needed.

PATIENT NAVIGATORS UMGCCC has dedicated clinical/administrative coordinators for our breast, gastro-intestinal, and head and neck programs, who supplement the physician and nurse teams in coordinating care for first-time and long-term patients. Our goal is to expand the service to other cancer types including lung/thoracic cancers and gynecologic oncology. We have an opportunity to advance the role of all navigators across our medical system as referrals of the most complicated cases come to UMGCCC from around the UMMS network of cancer centers.

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Our State takes enormous pride in all that the Greenebaum Cancer Center has accomplished. When I was diagnosed with stage three Non-Hodgkin’s Lymphoma, I came to the Greenebaum Cancer Center for my care. I came to appreciate the Center’s work in ways I could not have imagined. Thanks

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to the world-class care I received, I have the opportunity to continue serving the people of this great State.

— Governor Larry Hogan, Grateful Patient

From left to right: First Lady Yumi Hogan, Governor Larry Hogan, and Jaymi Sterling

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Every patient at UMGCCC is treated by a multidisciplinary care team that creates a highly personalized plan to meet their individual needs.

opportunity for UMGCCC to enhance patient experiences, increase access to care, and

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This campaign presents an extraordinary

change the nature of cancer care for those in Baltimore, Maryland, and beyond.

— Kevin J. Cullen, MD, Director, UMGCCC

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OUR CALL TO ACTION: INVEST IN BETTER HEALTH AND BETTER LIVES A cancer diagnosis can happen to anybody—young or old, rich or poor. Access to quality, leading-edge care is essential to all for survival.

As part of an academic medical center, UMGCCC is unique in its ability to deliver state-of-the-art clinical care to current patients while improving the health and wellbeing of future patients through discovery and training of next-generation caregivers. Our faculty-physicians are experts in their field and patients can be confident that they receive the most up-to-date treatment recommendations.

UMGCCC is committed to enhancing care for all cancer patients. The Building for Life Campaign will accelerate what our care teams can accomplish through investments in research, education, and patient support services. The new Roslyn and Leonard Stoler Center for Advanced Medicine will enhance the experience of all patients, families, care providers, and staff for generations to come. Ultimately, it presents a singular opportunity to improve lives and health outcomes for patients.

Thanks to the investment of Roslyn and Leonard Stoler—combined with a $125 million capital grant from Maryland along with UMMC resources—we are moving forward with construction of the Roslyn and Leonard Stoler Center for Advanced Medicine. The Building for Life Campaign has also received generous support from donors to fund professorships, innovative research, and programs that enhance the patient experience. To make real the future we envision, we seek to secure significant additional philanthropy to support our $55 million campaign goal.

Join us in elevating lives.

Your gift will transform lives, save lives, and extend lives.

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To move faster, to increase our impact, to bring even more benefits to patients, we need partners who share our vision.

[

This effort requires collaboration among our state, corporate and foundation partners, and individual investors.

From left to right: Mohan Suntha, MD, President and CEO of UMMS; Kevin J. Cullen, MD, Director, UMGCCC; William E. “Brit” Kirwan, PhD, Building for Life Campaign Chair

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UNIVERSITY OF MARYLAND MEDICAL CENTER 22 S. GREENE ST. BALTIMORE, MD 21201 PHONE: 410-328-5770 | EMAIL: UMMS-FOUNDATION@UMM.EDU 1.2022