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Lymphocytesworktogetherwithothercellsintheimmunesystemtodefendthebodyagainstinvasionbybacteria,viruses,parasites,andotherforeignNonHodgkinlymphoma(NHL)isamongthesevenmostcommoncancersaffectingadultsintheU.S.ThenumberofnewcasesofNHLintheUSnearlydoubled betweenbuthavesinceremainedstableItchinessonNon-Hodgkinlymphomarepresentsawidespectrumofillnessesthatvaryfromthemostindolenttothemost aggressivemalignanciesJS(12)AcademicUnitofClinicalOncology,Non-Hodgkinlymphomasymptomscaninclude:Painless,enlargedlymphnodesinyour neck,groinorarmpitLancet;–PublishedOnlineRankCasesASR(World)MortalityDiffuselargeBcellisthemostcommontypeofintermediateaggressive NHLThetypeoflymphomaisimportantforprognosisandforguidingtreatmentHodgkinlymphomahasanincidenceof2–3per,individualsperyearThe incidenceofNHLintheUnitedStates(US)nearlydoubledbetweenand,whiletherateshavesincestabilizedVariousfactorsseemtofavortheoccurrenceof HL.ThesignificantlyincreasedriskofidenticaltwinsstronglyindicatestheroleofgeneticsinHLItaimstoimprovecareforpeoplewithnon-Hodgkin'slymphoma byNon-Hodgkinlymphomasarelymphoidmalignantneoplasmswithdiversebiologicalandclinicalbehavior.Inadditiontoadiseasepeakinthethirdadeoflife, thereisasecondpeakintheagegroupoveryears[12,13]GLOBOCANIncidenceTheyarisefromlymphocytesthatareatIntroductionPatientstypically presentwithpersistentpainlesslymphadenopathy,Non-HodgkinLymphomaThereareoverdifferenttypesofNHLdefinedintheWHOclassificationof hematologicmalignanciesAnestimateof,newcasesofNHLwillbediagnosedintheUSbytheendofNON-HODGKINLYMPHOMA:Males 1RWDSSOLFDEOH1RGDWDAgestandardized(World)incidencerates,Non-Hodgkinlymphoma,males,allagesLeukemia&LymphomaSocietyBlood CancerLeadersLLSCOMMUNICATIONisKEY!LymphomaisnotjustonetypeofcancerAguideforpeoplewithcancer,theirfamiliesandfriendsNONHODGKINLYMPHOMA.AguideNon-Hodgkinlymphoma(NHL)isamongthesevenmostcommoncancersaffectingadultsintheU.S.Thenumberofnew casesofNHLintheUSnearlydoubledbetweenNon-HodgkinlymphomaForinformation&support,callUnderstandingNon-HodgkinLymphomaNonHodgkinlymphoma(NHL)isaneoplasmofthelymphoidtissuesoriginatingfromBcellprecursors,matureBcells,Tcellprecursors,andmatureTcellsAn estimateof,newcasesofNHLwillbediagnosedintheUSin7UnderstandingNon-HodgkinLymphomaChapterUnderstandingtheDiseaseNon-Hodgkin lymphoma(NHL)isatypeofbloodcancerthataffectsspecializedwhitebloodcellscalledlymphocytesRankDeathsASR(World)CancerThisguidelinecovers diagnosingandmanagingnon-Hodgkin'slymphomainpeopleagedyearsandoverNon-Hodgkinlymphomacomprisesvarioussubtypes,eachwithdifferent epidemiologies,etiologies,immunophenotypic,genetic,clinicalfeatures,andresponsetotherapyNon-Hodgkinlymphoma(NHL)istheseventhmostcommon canceraffectingadultsintheUnitedStates.Fatigue(extremetiredness).Shortnessofbreath.