UH Department of Medicine Annual Report 2022-2023

UH DEPARTMENT OF MEDICINE

ALOHA FROM THE CHAIR.

OUR FACULTY

DEPARTMENT LEADERSHIP

FACULTY BY DIVISION

FACULTY HIGHLIGHTS

DIVISION HIGHLIGHTS

MEDICAL STUDENT EDUCATION

GRADUATE MEDICAL EDUCATION

UNIVERSITY OF HAWAI'I INTERNAL MEDICINE RESIDENCY PROGRAM (UHIMRP)

CARDIOVASCULAR DISEASE (CVD) FELLOWSHIP PROGRAM

COMMUNITY ENGAGEMENT

AMERICAN COLLEGE OF PHYSICIANS (ACP) HAWAI'I CHAPTER

PAPAKOLEA HEALTH FAIR

AWARDS

CLINICAL FACULTY SERVICE AWARDS

ELIZABETH "LIZ" KEALI'IKUA'AINA TAM, M.D. MEMORIAL AWARD

RESEARCH ENDEAVORS

CENTER FOR CARDIOVASCULAR RESEARCH (CCR)

ALOHA FROM THE CHAIR

I would like to take this opportunity to present the Department of Medicine report. May 11, 2023 marked the end of Emergency for COVID-19, but we continue to emerge from the pandemic without complete knowledge of the long-term sequelae from infection and dealing with the acute healthcare provider shortages. Nevertheless, the past academic year was marked by the following successes for the Department:

53 active or new research grants for the Department's faculty totaling over $4,000,000 and 71 peer-reviewed research publications.

11 promotions including 3 full professors in the M-series

We honored the members of our clinical faculty who have unselfishly and steadfastly taught medical students and residents for over 10, 15, 20 and 30 years. (Without our 345+ clinical faculty, we would have neither an accredited medical school, nor an internal medicine residency program.)

In the spring of 2023, we submitted an application for a new UH Primary Care Internal Medicine Residency Program –the first application of a full residency program sponsored by UH in over 30 years! The goal is to fill the ranks of sorely needed primary care internists throughout the State of Hawaii.

We awarded the first recipient, Reid Ikeda MD, the inaugural Dr. Elizabeth Tam Award, which perpetually honors Dr. Tam’s core values during her tenure as the Department of Medicine Chair.

In response to the physician shortage especially on the Neighbor Islands, we implemented a recruitment strategy for primary care on the Neighbor Islands and hired two Department of Medicine faculty, Dr. Sydney Tatsuno and Dr. Dane Kurohara, who reside on Hawaii Island and Maui, respectively. These neighbor island physicians are instrumental in leading and building undergraduate and graduate medical education for the Department.

We celebrated the retirement of Dr. Roland Ng, who for decades played a key role in medical resident and student education at Kuakini Medical Center.

There is much work to be done in Academic Year 2023-2024 and I appreciate all of the important contributions and sacrifices that the Department of Medicine faculty and team offer to be able to grow and celebrate successes. I wish you another and even more successful year!

Sincerely,

Scott Kuwada, MD Chair and Professor of Medicine

DEPARTMENT LEADERSHIP

Scott K. Kuwada, MD

Professor and Interim Chair

Todd B. Seto, MD, MPH

Associate Professor and Vice Chair

Dominic Chow, MD, PhD, MPH

Professor and Associate Chair of Research

Christie Izutsu, MD

Assistant Professor and Associate Chair of Undergraduate Medical Education

Miki Kiyokawa, MD

Assistant Professor and Associate Chair of Clinical Faculty

OUR PAID AND VOLUNTEER FACULTY

GENERAL MEDICINE - HOSPITAL MEDICINE

Gary Ahn, MD

Kristie Akamine, MD

Henry Cacanindin, MD

Bo Yin Chang, MD

Christina Chong, MD

Wayne Chun, MD

Irina Crook, MD

Serena Del Mundo, MD

Gautam Deshpande, MD

Mai-Linh Frascarelli, MD

Michael Furlong, MD

Ashish Goyal, MD

Joanna Griffin-Boyce, MD

Julianne Griswold, DO

Catherine Ho, MD

Ryan Honda, MD

Daniel Hong, MD

Dorothy Iwanski, DO

Susannah Jensen, MD

Diana Kim, MD

Miki Kiyokawa, MD

Christopher Kwock, MD

Jatinder Lachar, MD

Ynhu Le, MD

Qi Jie Nicholas Leo, MD

Henry Lew, MD

Kuo-Chiang Lian, MD

Yuree Lin, MD

Sandra Loo, MD

Van Luu, MD

George Macris, MD

Thomas Maglinao, MD

Monica Mau, MD

Larissa Medina, MD

Francisco Mercado Jr., MD

Fatema Merchant, MD

Christopher Middleman, MD

Keisuke Miyamoto, MD

Chi-Cheng Morehead-Yang, MD

Nani Morgan, MD

Kelly Nakamura, MD

Toni Narimasu, MD

Paul Nho, MD

Jennifer Nishioka, MD

Masayuki Nogi, MD

Neil Onizuka, MD

Ronald Pangilinan, MD

Robert Pangilinan, MD

Dawn Peterson, DO

Jason Pirga, MD

Stephanie Pyskir, MD

Malia Ramirez, MD

Young Soo Rho, MD

Makiko Sawada, MD

Hannah Schmitz, MD

David Spinks, MD

Alison Tamiya, MD

Aileen Tamura, MD

Raquel Tello, MD

Richa Varshney, MD

Alena Velasco-Hughes, MD

Christine Wang, MD

Travis Watai, MD

Jordan Winston, MD

Stephanie Yoshimura, MD

Satomi Zukeran, MD

Rachel Ackerman, MD

Julie Andrada, MD

Timothy Au, MD

Lisa Barville, MD

Steven Brauer, MD

Bryan Brown, MD

Francis Buto, MD

Vanessa Cabe, MD

Lisa Camara, MD

Boyuan Cao, MD

Dee-Ann Carpenter, MD

Li-Hsieh Chen, MD

Hausen Cheong, MD

Baron Ching, MD

Keila Ching, MD

Chelsea Ching-Endow, MD

Chisoo Choi, MD

Dominic Chow, MD, PhD

Bradley Chun, MD

John Chung, MD

Carrie Colmenares Roys, MD

Anne Dempsey, MD

Stephen Denzer, MD

Emily Diep, MD

Maegan Doi, MD

Nathaniel Enriquez, MD

Clayton Everline, MD

Yue Fang, MD

GENERAL MEDICINE - PRIMARY CARE

Janice Fong, MD

Victoria Fox-Behrle, MD

Daniel Gallares, MD

Mina Ganapathy, MD

Rebecca Gelber, MD

Martin Guerrero, MD

Amanda Haley, MD

Scott Himeda, MD

Deborah Hirose-Ridao, MD

Aaron Hoo, MD

Gregory Howick, MD

Jason Hughes, DO

Birendra Huja, MD

Noriko Hunter, MD

Malissa Iida-Takashima, MD

Elliot Kalauawa, MD

Florence Kan, MD

Janet Kao, MD

Naomi Karlen, MD

Jennifer Katada, MD

Misao (George) Kawamura, MD

Kelly Kawaoka, MD

Kenneth Kepler, MD

Elizabeth Kiefer, MD

Claudine Kimura, MD

Katherine Kingsley, MD

Elizabeth Koehler, MD

Jeremy Kort, DO

Dane Kurohara, MD

Todd Kuwaye, MD

Sharon Lawler, MD

Nicole Leong, MD

Sandy Liang, MD

Mark Lum, MD

Anthony Magliulo, MD

Robin Matsukawa, MD

Kenneth Minami, MD

John Misailidis, MD

Ashley Morisako, MD

Aaron Morita, MD

Ronald Morton, MD

Mitchell Motooka, MD

Stuart Nakamoto, MD

Travis Nakamura, MD

Ashlee Nekoba, MD

Stephen Oishi, MD

Reese Omizo, MD

Janet Onopa, MD

Vanessa Osedo-Bleecher, MD

Abhinetri Pandula, MD

Stefanie Park, MD

Elizabeth Quinn, MD

Glenn Rediger, MD

Tara Reed, MD

Aldrich Alden Ricalde, MD

Macario Rivera, Jr., MD

Cameron Ryan, MD

Daniel Saltman, MD

Florian Sattelmacher, MD

Kenneth Schwab, MD

Scott Serrano, MD

Robin Seto, MD

Dorothy Shigaki, MD

Craig Shikuma, MD

Royce Shimamoto, MD

Helen Sim, MD

Anthony Siu, MD

Matthew Slavin, MD

Lisa Sodetani, MD

John Taitano, MD

Brandon Takase, MD

Marissa Takase, MD

Laurie Tam, MD

Dawn Taniguchi, MD

Eugene Tareshawty, MD

Sydney Tatsuno, MD

Nadine Tenn Salle, MD

Laura Wong, MD

Lydia Wong Takazawa, MD

James Yess, MD

ALLERGY & IMMUNOLOGY

Matthew Lau, MD

John McDonnell, MD

Megan Motosue, MD

Bruce Nelson, MD

Marina Ostroukhova, MD

CARDIOLOGY

Omar Abdul Ghani, MD

Michael Aldridge, MD

Steven Azuma, MD

Ramy Badawi, MD

Denny Bales, MD

Dipanjan Banerjee, MD

Giselle Baquero Caranama, MD

William Boisvert, PhD

Michael Brodsky, MD

Michael Chan, MD

Sanah Christopher, MD

John Cogan, MD

Samuel Dacanay, MD

Osamu Fukuyama, MD

Paul Ho, MD

Randolph Hutter, MD

Gautham Kanagaraj, MD

John Kao, MD

Kris Kawamoto, MD

Anne Kemble Luo, MD

Zia Khan, MD

Alan Kuo, MD

Helaine Kwong, MD

Carol Lai, MD

Luke Lam, MD

Rachel Lee, MD

Joana Magno, MD

Jesus Pino Moreno, MD

Benjamin Plank, MD

Kahealani Rivera, MD

Kevin Salire, MD

Katie Schoenman, MD

Michelle Seidel Tallquist, PhD

Todd Seto, MD

Neal Shikuma, MD

Ralph Shohet, MD

David Singh, MD

Andrew So, MD

Michael Tanoue, MD

Margo Vassar, MD

Mahdi Veillet-Chowdhury, MD

Sekon Won, MD

DERMATOLOGY

John Boyer, MD

Kevin Dawson, MD

Wayne Fujita, MD

Miki Garcia, MD

Roman Glamb, MD

Sarah Grekin, MD

Frederick Harada, MD

Philip Hellreich, MD

Douglas Johnson, MD

ENDOCRINOLOGY

Michael Bornemann, MD

Isabel Casimiro, MD, PhD

Judith Dickert, MD

Sophia Hazel, DO

Paul Kim, MD

Jennifer Loh, MD

GASTROENTEROLOGY

Christopher Aoki, MD

Daniel Chan, MD

Larissa Fujii-Lau, MD

Daryl Fujiwara, MD

John Garvie, MD

James Grobe, MD

Shilpa Jain, MD

Ankur Jain, MD

Robert Jao, MD

Scott Kuwada, MD

Herbert Lim, MD

Kristi Lopez, MD

Joseph Manlolo, MD

Dylan Lee, MD

Christopher-Allan Lum, MD

Joseph McKinlay, MD

Westley Mori, MD

Carla Nip-Sakamoto, MD

Ethan Routt, MD

Greg Sakamoto, MD

Ryan Sato, MD

Steven Lum, MD

John Melish, MD

Alan Parsa, MD

Cindy Pau, MD

Kelsey Shikuma Lee, MD

Lisa Wong, MD

Traci Murakami, MD

Fernando Ona, MD

Mel Ona, MD

Gavin Park, MD

Anahita Rezaie, MD

Neal Shimoda, MD

Jennifer Tamai, MD

Chuong (Jason) Tran , MD

Naoky Tsai, MD

Matthew Tsushima, MD

Russell Yang, MD, PhD

Brandon Yim, MD

HEMATOLOGY/ ONCOLOGY

Jared Acoba, MD

Jeffrey Berenberg, MD

Jami Fukui, MD

Jon Fukumoto, MD

Brian Issell, MD

Jodi Kagihara, MD

Kaye Kawahara, MD

William Loui, MD

INFECTIOUS DISEASE

Erlaine Bello, MD

Joel Brown, MD

Sharon Chi, MD

Heath Chung, MD

Tarquin Collis, MD

Larry Day, MD

Jonathan Dworkin, MD

Louie Gangcuangco, MD

John Raymond Go, MD

Heidi Hillesland, MD

NEPHROLOGY

Rossini Botev, MD

Shiuh-Feng Sherwin Cheng, MD

Troy DeNunzio, MD

Chuong (Jason) Dinh, MD

Rick Hayashi, MD

James Ireland, MD

Christie Izutsu, MD

Brian Lee, MD

Gordon Nakano, MD

Ryon Nakasone, MD

Elizabeth Nakasone, MD, PhD

Jessica Rhee, MD

Kenneth Sumida, MD

David Tamura, MD

Naoto Ueno, MD, PhD

Nicolas Villanueva, MD

NEUROLOGY

Stacy Brown, MD

Michiko Bruno, MD

Monique Canonico, MD

Vivian Chin, MD

Karen DaSilva, MD

Todd Devere, MD

Alexandra Galati, MD

Fay Gao, MD

Brandon Hirota, MD

David Kaminskas, MD

Eric Kajioka, MD

Sarah Kemble Verhoef, MD

Joseph Koo, MD

Doanh Lu, MD

Francis Pien, MD

Brian Pien, MD

Cecilia Shikuma, MD

Benjamin Thomas, MD

John Vaz, MD

Royden Young, MD

Christopher Middleman, MD

David Na'ai, MD

Roland Ng, MD

Kunal Parekh, MD

Carmen Stanko, MD

Jared Sugihara, MD

Thomas Tasaki, MD

Kalani Yamamoto, MD

Matthew Koenig, MD

Christopher Kurahashi, MD

Kore Liow, MD

Jeffrey Liu, MD

Michael Lui, MD

J Douglas Miles, MD, PhD

Karen Morgenshtern Yacoby, MD

PAIN & PALLIATIVE CARE

Ilan Bernstein, MD

Michael Duick, MD

Merle Mirua Akamine, MD

Nicholas Muraoka, MD

Coswin Saito, MD

Maria Termulo, MD PC

Kazuma Nakagawa, MD

Beau Nakamoto, MD

Stuart Pang, MD

Viren Patel, MD

Katherine Podraza, MD

Ray Romero, MD

George Weber Ross, MD

Peter Rossi, MD

Michael Russo, MD

Rony Salem, MD

Terry Shimamoto, MD

Alan Stein, MD

Jason Viereck, MD, PhD

Melvin Wong, MD

Victoria Wong, MD

Melvin Yee, MD

PULMONARY/ CRITICAL CARE

Benjamin Berg, MD

Reid Ikeda, MD

Ehab Daoud, MD

Gehan Devendra, MD

T. Scott Gallacher, MD

Emilio Ganitano, MD

John Kot, MD

Brent Matsuda, MD

Alvin Furuike, MD

Julius Pham, MD

Bruce Soll, MD

Christopher Fiack, MD

Donald Helman, MD

Artur Krupa, MD

Janet Myers, MD

Jonathan Paladino, MD

Phillip Verhoef, MD

Danilo Ablan, MD

Nishal Brahmbhatt, MD

Anjuli Brighton, MD

Christian Castaneda, MD

Hangyul Chung-Esaki, MD

Graham Cormack, MD

Eric Crawley, MD

Samuel Evans, MD

Russell Gilbert, MD

Stephanie Guo, MD

Karin Halvorson, MD

Malcolm Haruno, MD

Hao Chih Ho, MD

Ryotaro Kato, MD

David Kim, MD

Karthik Kode, MD

Sailaja Kolli, MD

Sreenandh Krishnagopalan, MD

Gary Kuniyoshi, MD

Jordan Lee, MD

Peter Lee, MD

Anthony Migura, MD

Angelina Narashima, MD

Hiro Sung, MD

Kahoko Taki, MD

Brent Tatsuno, MD

Bradley Tokeshi, MD

Yash Trivedi, MD

Makoto Uchiyama, MD

Mark Valdez, MD

Timothy Vossler, MD

Thomas Wong, MD

James Yang, MD

Brandon Yim, MD

Roger Yim, MD

REHABILITATION MEDICINE

Cedric Akau, MD

Merle Miura-Akamine, MD

Nicholas Muraoka, DO

Coswin Saito, MD

Jordan Wang, MD

RHEUMATOLOGY

Mary Ann Antonelli, MD

Ken Arakawa, MD

David Finger, MD

Sadao Jinno, MD

James McKoy, MD

Jefferson Roberts, MD

Alberto Santos Ocampo, MD

Mari Shiraishi, MD

Kristine Uramoto, MD

Kelly Wachi, MD

RESEARCH

Yuka Eto, MD

Toshihiro Hatakeyama, MD, PhD

Christina Higa, PhD

Eun-Ran Kim, PhD

Jinseung Kim, PhD

Juok Park, PhD

Christoph Rettenmeier, PhD

Eri Sato, PhD

Scott Souza, PharmD

Victor “Andy” Stenger, PhD

Wesley Sumida, PharmD

Toshiko Tomisawa, PhD

Machiko Yagi, PhD

Hiroshi Yonekura, PhD

Zidan Yu, PhD

Guangxiang Zhang, PhD

2022-2023 FACULTY HIGHLIGHTS

JARED ACOBA, MD

ASSOCIATE PROFESSOR ONCOLOGY

Was promoted to Associate Professor. Continued the phase II study of TSR-022 in combination with TSR-042 for the treatment of advanced hepatocellular carcinoma (PI). Authored four peer-reviewed articles, including "Racial Disparities in Patient-Provider Communication During Telehealth Visits Versus Face-to-face Visits Among Asian and Native Hawaiian and Other Pacific Islander Patients With Cancer: Cross-sectional Analysis" which was published in JMIR Cancer and "Pancreatic cancer among Pacific Islanders: a comprehensive analysis of an understudied racial group" published in Ethnicity & Health.

DIPANJAN BANERJEE, MD, MS

ASSOCIATE PROFESSOR CARDIOLOGY DIVISION CHIEF

Was promoted to Associate Professor. Received an Excellence in Cardiology teaching award for the fourth consecutive year from the UH Internal Medicine Residency Program.

ERLAINE BELLO, MD

ASSOCIATE PROFESSOR INFECTIOUS DISEASE DIVISION CHIEF

Was appointed Interim Program Director, Primary Care Track, UHIMRP and continued to lead The Queen's Health Systems Infection Prevention and Control Department's COVID-19 activities.

BENJAMIN BERG, MD PROFESSOR PULMONARY/ SIM TIKI

Authored the book chapter "Remote Faculty Development Programs for Simulation Educators-Tips to Overcome Barriers" in Advances in Smart Healthcare Paradigms and Applications. Composed five peerreviewed articles including "Simulation Past, Present, and Future" published in Clin and Exp Emerg Med. Received an academic award from the Fellow Society of Simulation in Healthcare Academy. As an invited speaker, presented at 10 international workshops and conferences, including the Collaborative Co-Learning Simulation workshops (COCOSIM) and the Korean Society for Clinical Procedures and Education.

WILLIAM BOISVERT, PhD PROFESSOR CARDIOLOGY

Continued his research "NIH Monocytes and macrophages in HIV cardiovascular risk" (PI) and "AHA Lipid metabolism in the endothelium" (PI). Was part of the teams to author "Alterations in Renin–Angiotensin System (RAS) Peptide Levels in Patients with HIV" published in Metabolites and "Characterization of circulating fibrocytes in people living with HIV on stable antiretroviral therapy" published in ImmunoHorizons. As an invited speaker, presented his research at the Joint Meetings of Coronary Revascularization (JCR) and the Cardiac Regeneration and Vascular Biology Conference.

STACY BROWN, MD

ASSISTANT PROFESSOR NEUROLOGY

Continued her research “Genetic Determinants of Cerebrovascular Disease and Brain Resilience in Multi-Ancestral Hawaiian Populations" and “Perceptions of Genomic Medicine and Technology among Native Hawaiian Patients Enrolled in a Longitudinal Healthcare Engagement Program” (PI). Authored "A genome-wide association study of frailty identifies significant genetic correlation with neuropsychiatric, cardiovascular, and inflammation pathways" published in Geroscience. Presented her research at the National IDeA Symposium of Biomedical Research Excellence and the Society of Neurointerventional Surgery.

CHRISTINA CHONG, MD

ASSISTANT PROFESSOR HOSPITAL MEDICINE

Received Faculty Award for Excellence in Teaching from the UH Internal Medicine Residency Program for her second consecutive year. Collaborated with residents in authoring "Are Patients with HHV-8 Associated Castleman Disease Successfully Treated with Rituximab at Risk of Subsequently Developing HHV-8 Negative (Idiopathic) Castleman Disease?" and "Eosinophilic Myocarditis Presenting as Cardiac Tamponade: A Diagnostic Challenge", both published in the European Journal of Case Reports in Internal Medicine.

DOMINIC CHOW, MD, PhD, MPH PROFESSOR PRIMARY CARE

Was named Educator of the Year by the Hawaii Chapter of the American College of Physicians. Continued his research on the "Role of Monocyte/Macrophage in HIV-related Cardiovascular Risk" (PI) and "Unpacking the Mechanisms of Disparities for HIV-Related Hypertension in African American and Asian Pacific American Men who have Sex with Men (MSM) Study", along with five additional grants. Authored 11 peer-reviewed articles, including "Increased Transmigration of Intermediate Monocytes Associated with Atherosclerotic Burden in People with HIV on Antiretroviral Therapy" published in AIDS. Gave 6 presentations at national conferences, such as the 2022 CHEST Annual Meeting and the 2022 and 2023 Conference on Retroviruses and Opportunistic Infections (CROI).

EHAB DAOUD, MD

ASSOCIATE PROFESSOR CRITICAL CARE

Was promoted to Associate Professor. Received Faculty of the Year Award from JABSOM and Physician "Respiratory Champion" Award from the Hawaii Society of Respiratory Care for his second year. Continued to serve as the Founder and President of the Society of Mechanical Ventilation and Editor in Chief of the Journal of Mechanical Ventilation.

GEHAN DEVENDRA, MD

ASSISTANT PROFESSOR PULMONARY/ CRITICAL CARE DIVISION CHIEF

ing for his research "Factors Responsible for the Pulmonary Post-Acute Sequelae of SARS-CoV-2 in Hawaii" (PI). Authored three peer-reviewed Phenotypic alteration of low-density granulocytes pulmonary post-acute sequalae of SARS-CoV-2 p ed in Front Immunol. Presented at 10 speaking engagements held at conferences such as the 2023 American Thoracic Society International Conference, Conference on Retroviruses and Opportunistic Infections (CROI), and CHEST Nashville 2022.

LOUIE GANGCUANGCO, MD, MSc

ASSISTANT PROFESSOR INFECTIOUS DISEASE

Joined the Department in July 2022. Authored three peer-reviewed articles, including "The State of the HIV Epidemic in the Philippines: Progress and Challenges in 2023" in Tropical Medicine and Infectious Disease and "Factors associated with colorectal cancer screening adherence and the impact of COVID-19 on screening patterns in Connecticut, USA" in Internal Emergency Medicine. He is the new Principal Investigator of the Pacific AIDS Education and Training Center for the Hawaii and US-affiliated Pacific Islands, leading HIV education in the Pacific.

REID IKEDA, MD

MIKI KIYOKAWA, MD

ASSISTANT PROFESSOR HOSPITAL MEDICINE & ADDICTION MEDICINE

Was appointed Associate Chair of Clinical Faculty for the Department. Received two Outstanding Teaching Awards for General Psychiatry and Addiction Medicine, presented by the UH Department of Psychiatry. Continued her research "Facilitators and barriers to implementation of a pilot methamphetamine treatment program at a Level I trauma center" (Co-I). As an invited speaker, presented at the American College of Academic Addiction Medicine Weekly Didactic Sessions and the Hawai'i Department of Health Alcohol and Drug Abuse Division Webinar.

ASSOCIATE PROFESSOR PULMONARY/ CRITICAL CARE

Continued in his role as Program Director of the UH Internal Medicine Residency Program. Continued in his role as the American Lung Association of Hawaii and Leahi Fund Endowed Chair in Respiratory Health. Continued research projects focusing on "The Role of Biomarkers in Predicting the Successful Application of High-Flow Nasal Cannula (HFNC) in COVID-19 Pneumonia." Received the Elizabeth "Liz" Keali'ikua'aina Tam, MD Memorial Award.

ZIA KHAN, MD, MPH

ASSISTANT PROFESSOR CARDIOLOGY DIVISION CHIEF

ardiology Division Chief. Served as Chief of Queen’s d Medical Director of Enterprise Access for Queen’s Served as Board President of Hawaii Division of Association. Po’okela Award for Leader of the Year loped RIDGETRail Medical Education Certification Pathway Pilot for Cardiology.

MATTHEW KOENIG, MD

ASSOCIATE PROFESSOR ONCOLOGY

Continued his research “Kinā’ōle: Expanding Telestroke Coverage to the Prehospital Setting in Hawaii’s Rural Communities HRSA Telemedicine Network Grant Program (TNGP)” (PI).

DANE KUROHARA, MD

ASSISTANT PROFESSOR RIMARY CARE

Assistant Professor, our first departmental-funded n Maui island, a key step towards expanding our ms in neighbor islands.

SCOTT KUWADA, MD

INTERIM CHAIR AND PROFESSOR GASTROENTEROLOGY DIVISION CHIEF

Received three new grants for the academic year, including the new U54 award for increasing colorectal cancer screening in Pacific Islanders in Hawaii and Guam.

KUO-CHIANG LIAN, MD

ASSISTANT PROFESSOR HOSPITAL MEDICINE

Received his third award for Excellence in Teaching from the UH Internal Medicine Residency Program.

J. DOUGLAS MILES, MD, PhD

ASSISTANT PROFESSOR NEUROLOGY

Was awarded the grant "Streamlining the Generation of Neurology Exam Animations for Teaching and Assessment" (PI). Presented at 9 speaking engagements such as the International Association of Medical Science Educators (IAMSE) 2023 Annual Conference and the 3rd International Congress of Health Education and Research & AoME Annual Academic Meeting. As an invited speaker, presented “Why Do I Have to Repeat That? (Or, What the Heck is That Doctor Thinking?)” at the 2023 American Association of Electrodiagnostic Technologists (AAET) Annual Conference.

KAZUMA NAKAGAWA, MD

ASSOCIATE PROFESSOR NEUROLOGY DIVISION CHIEF

Authored "Forkhead box O3 longevity genotype may attenuate the impact of hypertension on risk of intracerebral haemorrhage" in J Hypertens. Was part of the team who authored "FOXO3, a Resilience Gene: Impact on Lifespan, Healthspan, and Deathspan", published in J Gerontol A Biol Sci Med Sci. Presented his research at the Congress of International Society of Hypertension and the Alzheimer's Association International Conference (AAIC).

KELLY NAKAMURA, MD

ASSISTANT PROFESSOR INTERNAL MEDICINE

Was appointed Assistant Professor and Medical Student Site Coordinator for Queen’s Medical Center.

RYON NAKASONE, MD

ASSISTANT PROFESSOR HEMATOLOGY & ONCOLOGY

Co-authored "Disaggregating Data on Pacific Islander Gastric Cancer Patients Reveals Survival Disparity" published in J Gastrointest Cancer.

CHRISTOPH RETTENMEIER, PhD

ASSISTANT RESEARCHER

UH MAGNETIC RESONANCE RESEARCH CENTER

Continued his research "Cell-to-cell death along myofibers in ischemic heart disease" and "Longitudinal Study of Early NAFLD Progression and the Gut Microbiome in Asian Americans, Native Hawaiians and Whites" along with 3 additional grants. Was part of the teams to present at conferences such as the ISMRM & ISMRT Annual Meeting & Exhibition and Anatomy Connected.

MICHELLE TALLQUIST, PhD PROFESSOR CARDIOLOGY

Continued her research "Role of Fibroblasts in Cardiovascular Inflammation" (PI) and "Role of Lipofibroblast in Alveolar Development" (PI) along with 3 additional grants. Presented "Functional Consequences of Fibroblast Loss in Tissue Homeostasis and Disease" as invited guest at conferences held by the American Heart Association's (AHA) Basic Cardiovascular Sciences (BCVS) and International Service for Heart Research (ISHR).

TODD SETO, MD, MPH

VICE CHAIR & PROFESSOR CARDIOLOGY

Continued working on seven extramural grants including "Hawaii Clinical Research Network for Health Equity" (Co-PI) and "Hawaii Interdisciplinary Mentored Career Development in HIV CoMorbidities" (Co-PI). Authored "Differences in COVID-19 Hospitalizations by Self-Reported Race and Ethnicity in a Hospital in Honolulu, Hawaii" in Preventing Chronic Disease along with 4 other publications. Presented "Performance of Society of Thoracic Surgeons and EuroSCORE II pre-surgical mortality risk score for cardiac surgery in a large majority-minority population" at the European Society of Cardiology Congress.

ROYCE SHIMAMOTO, MD ASSISTANT PROFESSOR HOSPITAL MEDICINE

Received his third Kuakini Teaching Award, in recognition of his contribution to the UH Internal Medicine Residency Program. Also received the Kaiser-Permanente Excellence in Clinical Teaching award, which celebrates exceptional teaching in the third and fourth year clinical curriculum.

RALPH SHOHET, MD

PROFESSOR CARDIOLOGY

Continued work on ultrasound-targeted microbubble-based gene delivery, publishing a paper that showed this method could deliver CRISPR tools effectively to the liver. Initiated a project to explore the sex-specific cardiac damage of methamphetamine, and continued work on the epigenetics and metabolic consequences of cardiac hypoxia. Supervised the tenth year of the cardiovascular training grant and submitted a successful renewal with Dr. Tallquist as the new PI.

V. ANDREW STENGER, PhD PROFESSOR UH MAGNETIC RESONANCE RESEARCH CENTER

Continued his research "Radial Echo Volumar Imaging Grant" (PI), "Integrative Center for Precision Nutrition and Human Health", and "Effects of Intermittent Energy Restriction on Intra-Abdominal Fat and the Gut Microbiome: A Randomized Trial". Was part of the teams to present at conferences such as the Proceedings of the ISMRM & ISMRT Annual Meeting & Exhibition and the International Conference on Systems Engineering.

KENNETH SUMIDA, MD

ASSOCIATE PROFESSOR ONCOLOGY

Continued in his role as Director of Medical Education at Kuakini Medical Center and Adjunct Assistant Professor and Core Clinical faculty at the University of Hawai’i Cancer Center.

TRAVIS WATAI, MD

ASSISTANT PROFESSOR HOSPITAL MEDICINE

Was appointed Associate Program Director of the UH Internal Medicine Residency Program. Presented "Answers Lie in the Complete Blood Count: A case of Eosinophilic Granulomatosis with Polyangiitis presenting with Acute ST-wave Elevation Myocardial Infarction" at the 2022 CHEST Annual Meeting.

SYDNEY TATSUNO, MD

ASSISTANT PROFESSOR PRIMARY CARE

Was appointed as Assistant Professor, our first departmental-funded faculty member on Hawai’i island, a key step towards expanding our education programs in neighbor islands.

JAMES YESS, MD

ASSISTANT PROFESSOR PRIMARY CARE

Elected Chair of the Primary Care Advocacy Committee American College of Physicians Hawaii Division. Received Po’okela Award for Kilolani Native Hawaiian Care Team from the Queen's Health System. Was awarded the grants "Ola Hawaii Post Covid Pulmonary Long Covid Study" and "Perceptions of Genomic Medicine and Technology among Native Hawaiian Patient Enrolled in a Longitudinal Healthcare Engagement".

SION HIGHLIGHTS

faculty from a comprehensive array of subspecialties, including general electrophysiology, advanced cardiovascular imaging, advanced heart failure, and research. While we remain committed enhancing and improving Diseases, we additionally focused well as supporting faculty include:

FACULTY INITIATIVES

Initiating mentorships with cardiology faculty.

Developing subspecialty rotations for medical students, particularly in Advanced Heart Failure and Electrophysiology.

Formal didactics for the medical students, including ECG interpretation and physical exam teaching.

Mentorship for Project HEART, a medical student group designed to promote CPR in schools.

Precepting for blood pressure screening in Chinatown by medical students.

Developing a comprehensive Cardiac CT/MR educational curriculum for the fellows.

Offering the MS4 Cardiology elective (MED 545-C).

Drs. Seto and Banerjee were promoted to Full Professor. Dedicated monthly Cardiovascular Grand Rounds were started this year.

Hawai'i Cardiovascular Symposium, led by Dr. David Singh. Participation in planning of ACHD CATCH (Caring for Adults and Teens with Congenital Heart Disease) Conference by Dr. Anne Kemble.

Initiation of the RIDGETrail Medical Education

Certification Pathway for cardiologists on the inpatient teaching service.

Faculty serve as leaders local community organizations, including Dr. Vassar as Hawai'i American Academy of Cardiology President and Dr. Khan as Hawaii American Heart Association President.

GASTROENTEROLOGY

NEW FACULTY

Dr. Chuong Tran, Assistant Clinical Professor of Medicine, QUMG Liver Center and Transplant Center, graduated from JABSOM, completed residency and GI fellowship at Loma Linda, and completed transplant hepatology fellowship training at UCSF.

RESEARCH

Dr. Larissa Fujii-Lau, Assistant Clinical Professor was the lead- or co-author on 10 publications providing new guidelines for the American Society of Gastrointestinal Endoscopy.

Dr. Chuong Tran, Assistant Clinical Professor of Medicine, QUMG Liver Center and Transplant Center, was named the PI for a new federal grant (Hawaii Clinical Research Network for Health Equity [HICRN-HE] UG3MD018358) study on fatty liver disease (Main PI’s: Dr. Cecilia Shikuma, Dr. Todd Seto and Dr. Venkataraman Balaraman; mentor: Scott Kuwada, MD).

Dr. Scott Kuwada, Interim Chair and Professor of Medicine, Chief of Division of Gastroenterology, UH Cancer Center Seed Grant - Title: Meeting the looming epidemic of hepatocellular carcinoma in Hawaii. The aim of this grant is to recruit patients with metabolic disease associated steatohepatitis, which is overrepresented in Hawaii, with advanced fibrosis for for a dietary intervention trial. He was the senior author and co-author on two papers: Mansour MM, Obeidat AE, Darweesh M, Mahfouz R, Kuwada S, Pyrsopoulos NT. The Impact of Cirrhosis on Outcomes of Patients Admitted With Diabetic Ketoacidosis: A Nationwide Study. Cureus. 2022 Jun 12;14(6):e25870. Lee Anson Y, Kuwada SK. Use of an overthe-scope clip in managing adult anastomotic ulcer bleeding. J Surg Case Rep. 2023 Jun; 2023(6).

HOSPITAL MEDICINE

VISION STATEMENT

“As the leading Hospitalist Program in the Pacific Region, we foster a collaborative, supportive philosophy and value the strengths and wellbeing of each individual team member. We champion compassionate, high quality care, elevating patient experience and access. We are dedicated to life long learning, education and innovation.”

HOSPITALIST ACADEMIC PROGRAM

QUMG Hospitalists serve as the primary teaching attendings for learners

Manamana

UHIMRP and UHPC residents

JABSOM 3rd/4th year medical students

TAMC residents (elective), interns (this upcoming year)

Psychiatry interns

Teaching Structure/Size

4 Hospitalist Teaching Teams per day caring for ~50-55 Manamana

11 Dedicated Academic Hospitalists

Many more hospitalists hold clinical faculty appointments and rotate

HIGHLIGHTS

UHIMRP graduates pursue Primary Care (25%), Hospitalist Medicine

American Board of Internal Medicine board pass rate rolling 3 year 2020-2022, it was 89% (national average 87%).

>50% of our residents published or had an abstract accepted for pres year

88 UHIMRP graduates in the past 10 years are practicing in HI

14 are currently hospitalists with QUMG with 6 more joining this

**36 of 82 (44%) Manamana Hospitalists are JABSOM and/or UHIMRP graduates**

5 HOSPITALISTS WON EXCELLENCE IN TEACHING AWARDS

Dr. Sandra Loo

Dr. Kuo Lian

Dr. Christina Chong

Dr. Alena Velasco-Hughes

Dr. Hannah Schmitz

PUBLICATIONS/POSTER PRESENTATIONS

5 publications

5 poster presentations

NATIONAL CONFERENCES

4 Hospitalists served as Point of Care Ultrasound (POCUS) faculty at the joint UCSF-UH CME annual conference, 6/2023 (Royal Hawaiian) and anticipating this upcoming

STRATEGIES FOR IMPROVEMENT

Held 1st annual Hospitalist Faculty Development Retreat (5/2023)

Identified strategic goals for 2023-2024 Academic Year

upper level resident expectations

Aligned goals with Hospitalist Quality Projects

Increase faculty development through retreats, journal clubs,

Enhance resident night float academic experience

Embed case manager and social worker on 2 teaching teams

patient transitions

2023 Hospitalist Quality Projects with Academic focus

Standardize upper level resident expectations based on team structure

Revise resident progress note and H&P documentation templates

Launch Hospitalist Procedural Teaching Service

evercha expanded System, electives clinical faculty conside Activities

new ID colleagues entering clinical practice. ID faculty program leadership for UHIMRP.

in HIV. ID faculty support resident. While Dr Jonathan Dworkin’s Pandemic roles of many division members) was technically published in faculty also support UHIMRP research projects.

including but not limited to Infection Control, Medication/Pharmacy, input into and in some cases write policies and guidelines that serve on JABSOM committees and community Boards.

The Neurology Division is comprised of general neurologists and subspecialized neurologists with fellowship training in clinical neurophysiology, epilepsy, headache medicine, movement disorders, neuroimmunology, neurocritical care, neuromuscular medicine, sleep medicine and vascular neurology. All of the division members participate in the medical student and/or resident teaching programs; and some actively participate in clinical research.

Noteworthy accomplishments including collectively, through the Hawaii Stroke Coalition, with partnership of all the major hospitals in Hawaii, the quality and performance outcome for acute stroke treatment was shown to be significantly better than the U.S. mainland stroke centers.

TEACHING

As clinician-educators for the JABSOM medical students, residents and fellows, it is our obligation to inspire the students and trainees to become the future leaders of the field. Many of the division members participate in the Longitudinal Clinical Mentor program for the first and second-year medical students, as well as second-year medical students’ Clinical Skills Program during their Locomotor, Neurological, and Behavior System, 4th year inpatient and outpatient neurology elective, as well as Internal Medicine residents’ elective and selective rotations in outpatient and inpatient neurology.

RESEARCH

The Neurology Division’s overall research mission is to address health disparities among Native Hawaiians and other underserved population with various neurological conditions. The Queen’s Neuroscience Research program has 1) a research study funded by the Micheal J. Fox Foundation to assess disparities in care of Parkinson’s disease patients among Asian Americans, Native Hawaiians and Pacific Islanders, 2) NIH-funded multicenter study to assess disparities in blood pressure control and cognitive outcome among Native Hawaiians and Asians patients with intracerebral hemorrhage (REACH-ICH), 3) NIH/COBRE-funded study to investigate genetic determinants of cerebrovascular disease among multi-ancestral Hawaiian population. Hawaii Pacific Neuroscience sponsors multiple medical students to participate in research through their Summer Research Internship program. Both Queen’s Neuroscience Research and Hawaii Pacific Neuroscience research programs participate in multiple Phase I, II, and III clinical trials for various neurological disorders.

COMMUNITY OUTREACH

As clinician-educators for the JABSOM medical students, residents and fellows, it is our obligation to inspire the students and trainees to become the future leaders of the field. Many of the division members participate in the Longitudinal Clinical Mentor program for the first and second-year medical students, as well as second-year medical students’ Clinical Skills Program during their Locomotor, Neurological, and Behavior System, 4th year inpatient and outpatient neurology elective, as well as Internal Medicine residents’ elective and selective rotations in outpatient and inpatient neurology.

NEPHROLOGY

DIVISION OVERVIEW

The Division of Nephrology is dedicated to excellence in patient care, education and clinical advancements in the field of nephrology. As providers, we collaborate to manage complex patients across the state with chronic kidney disease and a growing transplant center which serves the entire Pacific basin. As educators, we facilitate the nephrology rotations for students and residents, paving the way for future nephrologists.

Roland Ng Retirement Celebration Community Nephrologists

nephrologists in private practice settings who partner with each of the major provide 24-hour coverage for both established and new patients in all high for conditions including acute kidney injury, end-stage renal disease

rotation involving inpatient and outpatient management of a variety of inpatient consultative service at Kuakini Medical Center and the Queen’s hemodialysis & peritoneal dialysis rounds, CKD clinic and transplant clinic. There research and develop individualized clinical rotations. Similar offerings interested in an in-depth two- or four-week experience in nephrology. Our division conferences including grand rounds for the University and Transplant Center, Session, MD3 and the surgery residency program.

several papers in JASN and in collaboration with NKF to highlight the kidney Pacific Islanders, as well as the overall growing need for greater nephrology conjunction with the state’s federally qualified healthcare centers to promote CKD patients and with the medical school on strategies to address these

PULMONARY/ CRITICAL CARE

DIVISION OVERVIEW

The Division of Critical Care Medicine spans multiple intensive care units (ICU) throughout Hawaii including staffing via virtual health to the Big Island and Kauai. We have staff that serves the ICUs at Queens Medical Center- Manamana, Queens Medical Center- West, Straub Medical Center, Pali Momi Medical Center, Kuakini Medical Center and Kaiser Monanalua Hospital. We have a total of over 100 ICU beds between our hospitals and have a range of ICU services including medical intensive care, cardiac intensive care, medical and surgical critical intensive care and also extracorporeal membrane oxygenation (ECMO). Over 7000 patients per year are admitted through our hospitals and treat a range of illness including septic shock, acute respiratory failure, pulmonary hypertension, heart failure, post cardiac arrest and post cardiac surgery. We also cannulate about 40 ECMO cases per year. The key staff of the simulation center at JABSOM is included in our faculty. Our physicians are a critical asset in the training of critical care medicine for the University of Hawaii Internal Medicine Residency Program, Tripler Internal Medicine Residency Program, University of Hawaii Family Medicine Residency Program, and the Kaiser Internal Medicine Residency Program.

MEDICAL STUDENT ATION

Burns School of Medicine (JABSOM)'s MD program is its use of Problem-Based Learning (PBL) and Community-based Medicine. Students are trained in affiliated hospitals and clinics, which gives them real-world from the start. Through PBL, our first and second are educated to think critically, to identify and information and learning issues by evaluating and data, and apply their new knowledge to the problem Departmental faculty hold key leadership and in PBL and Longitudinal Clinical Preceptorship mentoring students in clinical problem solving and communication with patients, their families, and other the health team. Third year students are introduced and depth of Inpatient and Ambulatory Internal Medicine, the foundation for all clinical specialties. During their required Internal Medicine Clerkship, they receive supervised, formative experiences in the evaluation and management of patients, spending 4 weeks in an inpatient setting and a semester in an outpatient setting. Fourth year medical students rotate through required and elective learning opportunities in general medicine and internal medicine subspecialties based on their interests and career goals. Our department alone offers a range of twenty fourth-year courses in both inpatient and outpatient settings, including neighbor islands. As a whole, our medical education program enables learners to achieve JABSOM's graduation objectives and helps assure accreditation of the school by the Liaison Committee on Medical Education while educating current and future healthcare professionals and leaders.

UNIVERSITY OF HAWAII

INTERNAL MEDICINE RESIDENCY PROGRAM (UHIMRP)

UH Internal Medicine Residency Program White Coat 2023. Deborah Dimaya photo taken on June 29, 2023.

A MESSAGE FROM THE PROGRAM DIRECTOR

I view UHIMRP as an extended family that emphasizes teamwork between our faculty, residents, students, and program staff. We aim to provide exceptional patient care, and to cultivate an optimal learning environment that is characterized by collegiality, shared responsibility, and professionalism.

Hawaii is a special place with rich diversity, and the spirit of Aloha should guide our interactions with patients and colleagues.

Mahalo, Dr. Reid Ikeda UHIMRP Program Director

OUR MISSION

Our MISSION is that residents, faculty and staff of UHIMRP will be dedicated to the service of our community in Hawai‘i and the Pacific through education, research and quality patient care.

OUR VISION

Our VISION is to become an ‘ohana (family) characterized by teamwork and mutual respect in a supportive learning environment. We envision a future in which we are integrated with the community, responsive and adaptive to change, and internationally renowned for excellence in patient care and the quality of our residents, faculty and medical education.

Noppawit Aiumtrakul,MD

ShuheiHattori,MD

DillonTacdol,MD

KyleAlimurung,MD

JulieHong,MD*

KensukeTakaoka,MD

KevinBenavente,DO

MohammadKhan,MD

R.HarisRizwan,MD

OUR RESIDENTS

LEVEL 1

Chinnawat Arayangkool,MD

KelseyKwong,MD

ArvinJeremyTan,MD

BolinChang,MD

Chesta,MD

JasonKuniyoshi,MD LandonKozai,MD

JoshuaTaylor,MD** HarukiSawada,MD

NicoleChong,MD**

AikoMurakami,MD

Manasawee Tanariyakul,MD

LEVEL 2

KyleDeacon,MD

JosephLee,MD

WitinaTechasatian,MD

TitusDavid,MD

StevenNamiki,MD

JonathanEstaris,MD

*Preliminary Track

**Primary Care Pathway

OsamaHasan,MD

KevinEdward Nebrejas,MD CarlyPappo,MD*

MaluikeauTang,MD** KristineVo,MD

MikiYokokawa,MD

BryanAaron Ganzon,MD

MaanGozun,MD 1/29/22-1/28/23

Thiratest Leesutipornchai,MD TarynMiyake,MD

BrendanTran,DO** ChaseWarashina,MD

GavinHa,MD

AndrewPham,MD

AmandaWasko,MD

MarciChock,MD 9/22/21-8/23/2022

BrysaKato,MD

HoryunChoi,MD

KoichiKeitoku,MD

TorreyCzech,MD

NobuhikoKimura,MD

ChristinaPark,MD

KeithSablan,MD

LEVEL 3

JosephGo,MD**

ChengchengLi,MD 09/28/22-09/27/23

ParthavShah,MD

AlisonGoo,MD** Robert Holm-Kennedy,DO

DanielMiyamoto,MD

BryceTanaka,MD

CHIEF MEDICAL RESIDENTS

NathanielEnriquez,MD

FlorenceKan,MD

ASSOCIATE PROGRAM DIRECTORS

TravisWatai,MD

RickyHuang,MD

ToddNagamine,DO

JihunYeo,DO

YoshitoNishimura,MD 09/01/22-08/31/23

StephanieYoshimura,MD 12/16/21-12/15/22

GeneYoshikawa,MD

PRIMARY CARE TRACK PROGRAM DIRECTOR

ErlaineBello,MD

JamesYess,MD

UH Internal Medicine Residency Program Graduation. Taken on June 2, 2023.

RESIDENT OF THE YEAR AWARD

Yoshito Nishimura, MD

EXCELLENCE IN RESEARCH

First Year:

Jonathan Estaris, MD

Second Year:

Maan Gozun, MD

Witina Techasatian, MD

Landon Kozai, MD

Third Year:

Yoshito Nishimura, MD

Parthav Shah, MD

QMC: OUTSTANDING INTERN & UPPER

Intern:

Nicole Chong, MD

Upper:

Yoshito Nishimura, MD

KMC: OUTSTANDING INTERN & UPPER

Intern:

Maluikeau Tang, MD

Upper:

Koichi Keitoku, MD

QEC: EXCELLENCE IN AMBULATORY MEDICINE

First Year:

Arvin Tan, MD

Second Year:

Kevin Benavente, MD

Third Year:

Todd Nagamine, MD

STRAUB: OUTSTANDING INTERN FOR STRAUB

MEDICAL CENTER ICU

Kelsey Kwong, MD

GOLDEN CRAB AWARD (SECRET)

Yoshito Nishimura, MD

OUTSTANDING TEAM PLAYERS

First Year:

Steven Namiki, MD

Second Year:

Haruki Sawada, MD

Jason Kuniyoshi, MD

Third Year:

Chengcheng Li, MD

Horyun Choi, MD

RECOGNITIONS:

Nicole Chong, MD

Manasawee Tanariyakul, MD

Kristine Vo, MD

Kevin Benavente, MD

Bolin Chang, MD

Chesta, MD

Kyle Deacon, MD

Bryan Ganzon, MD

Gavin Ha, MD

Mohammad Khan, MD

Landon Kozai, MD

Haris Rizwan, MD

Witina Techasatian, MD

Chase Warashina, MD

Amanda Wasko, MD

Alison Goo, MD

Brysa Kato, MD

Nobuhiko Kimura, MD

Daniel Miyamoto, MD

Todd Nagamine, MD

Bryce Tanaka, MD

Jihun Yeo, MD

CARDIOVASCULAR DISEASE (CVD) FELLOWSHIP

FELLOWSHIP EDUCATION

New cardiac CT/MRI rotation and curriculum: Lead by Dr. Veillet-Chowdhury.

Developing a new CCU/HF rotation curriculum for the fellows.

Development of cardiology didactic curriculum lead by Dr. Omar Abdul Ghani.

Wellness Curriculum Development lead by Dr. Margo Vassar.

Faculty Participation with the RIDGE trial run by Dr. Bryan Brown for faculty teaching education: Dr. Zia Khan, Dr. Helaine Kwong, Dr. Nath Limpruttidham, Dr. Michael Tanoue, Dr. Alan Kuo, Dr. Jesus Pino-Moreno.

MEDICAL SCHOOL EDUCATION INITIATIVES:

Project CARE: Please see attached document. Lead with Dr. Helaine Kwong.

Medical Student Mentorship Program: We have faculty involved in medical student mentorship: Dr. Omar Abdul Ghani.

Cardiovascular disease fellows volunteered in medical students’ educational activities throughout the year.

COMMUNITY/PHYSICIAN EDUCATIONAL DEVELOPMENTS:

Hawaii Cardiovascular Symposium 6/2023, lead by Dr. David Singh.

Caring for Adults and Teens with Congenital Heart Disease 10/2022: Dr. Anne Kemble-Lou on the planning committee.

PROJECT CARE

Project CARE (CPR and Rescue Empowerment), previous Project HEART, is a student-run organization at JABSOM that aims to connect with local public high school students who are pursuing a healthcare career and enrich their education by providing mentorship, promoting healthy lifestyles, and teaching them skills that will translate to their future profession.

IN PROGRESS/FUTURE DIRECTIONS:

QUMG CVD FELLOWS

FIRST YEAR FELLOWS

SECOND YEAR FELLOWS

THIRD YEAR FELLOWS

Increase high school visits to teach students about first aid, CPR, heart and lung physician exam, and different careers in the healthcare field

Update the case-based curriculum to incorporate other healthcare roles such as EMTs, nurses, dietitians, and physical therapists

Create a pamphlet with information about the education and training requirements for several healthcare careers, with emphasis on programs in Hawaii

Develop a new partnership with AMR to teach CPR at health fairs in the community; received resources including CPR kits

Expand our student team and created new leadership roles to direct our endeavors in connecting with more high schools, developing curriculum, and building relationships with community organizations

AndrewLee,MD KimberlyVu,MD

MonikaBernas,MD

NathLimpruttidham,MD JamesZhang,MD IsaacMizrahi,MD

RahulAhuja,DO

BenitaTjoe,MD GagandeepRajpal,MD PoojaDhruva,MD

AMERICAN COLLEGE OF PHYSICIANS (ACP) HAWAI’I CHAPTER

The American College of Physicians (ACP) Hawai’i Chapter received the Gold Level of the 2023 Chapter Excellence Award. The award recognizes truly extraordinary chapters that surpass excellence in chapter management. We are in the company of 54 other outstanding chapters. In order to achieve the Gold Level of the Chapter Excellence Award, chapters must meet nineteen Bronze criteria, seventeen Silver criteria and multiple Gold level activities. Criteria include such activities as having a legislative action plan or agenda, holding a volunteerism/community service activity, holding multiple stand-alone meetings, having revenue sources outside of dues and meeting registration fees, implementing a strategic plan, implementing a formal recruitment and retention plan and measuring outcomes, conducting various activities for Medical Students, Residents and Early Career Physicians.

2023 HAWAII CHAPTER

ANNUAL SCIENTIFIC MEETING

ABSTRACT COMPETITION WINNERS

RESIDENT RESEARCH

First Place: Horyun Choi, MD

"Phenobarbital for Alcohol Withdrawal: Systematic Review"

Second Place: Andrew Pham, MD

"The Role of Biomarkers in Predicting High Flow Nasal Cannula (HFNC) Success in COIVD-19 ARDS"

Third Place: Maan Gozun, MD

"Echocardiographic validity of the electrocardiographic diagnosis of left atrial enlargement in the elderly Asian population"

STUDENT RESEARCH

First Place: Amanda Chau, MD

"Mobility Device Use and Frailty Progression in Older Adults with Mobility Impairment"

Second Place: Mikayla Sonnleitner, MD

"Characteristics of Older Adults with Positive Neurocognitive Screens in the Geriatric ED"

Third Place: Eduardo Biala, Jr., MD

"Validation of the Edmonton Frail Scale-Acute Care in patients ≥ 65 years undergoing surgery"

Chapter Governor Dr. Sam Evans (left), Third Place Resident Research Winner Dr. Maan Gozun (center), and Program Chair Dr. Kuo-Chiang Lian (right).

TOP FELLOW RESEARCH PRESENTATION

Gull Mahvish, MD

"Improving Communication Skills Amongst Clinicians Through Formal Evidence Based Training"

TOP RESIDENT CASE PRESENTATION

Helena Holmgren, MD

"A Heart Stopping Case; Young Woman with Cardiac Tamponade, Right Atrial Mass, and Miliary Lung Nodules"

TOP MEDICAL STUDENT CASE PRESENTATION

Shirley Cheng

"Breast Nodular Fasciitis in a Postmenopausal Woman: A Case Report and Review of Recent Literature"

PAPAKOLEA ʻOHANA HEALTH FAIR

Our department recognizes the importance of community engagement and outreach in promoting health and wellness in Hawaii. Through partnerships with community organizations, and healthcare providers, we have been actively involved in health promotion activities, screenings, and educational seminars aimed at raising awareness about preventive health measures and disease management. Our participation in the Papakolea Ohana Health Fair each year brings together faculty, students, residents, and the community, providing an opportunity for all participants to exchange cultural and health practices.

The year 2023 has been marked by notable achievements and significant progress in the Department of Medicine. As we reflect on our accomplishments and challenges, we reaffirm our commitment to excellence, innovation, and service in the pursuit of improving human health and well-being. We extend our sincere gratitude to our faculty, staff, students, collaborators, and funding agencies for their dedication, support, and contributions to the success of the Department of Medicine research endeavors. Together, we are making a difference in advancing medical knowledge and improving the health and well-being of the people of Hawaii and beyond.

Looking ahead, the Department of Medicine is poised to continue its trajectory of excellence in research, education, and community engagement. We remain committed to addressing the evolving healthcare needs of our diverse population, fostering collaboration across disciplines, and translating research findings into tangible improvements in patient care and public health outcomes.

In appreciation of the enduring dedication of our Clinical Faculty Members towards our academic mission, the Department of Medicine has been honoring those who have volunteered on our faculty for more than 20 years. Service awards are being presented by medical students, residents, and other department members to recognize the extensive commitment of our longstanding Clinical Faculty.

CLINICAL FACULTY AWARDS

Steven Azuma, MD

36 Years of Service

Denny Bales, MD

36 Years of Service

Jeffrey Berenberg, MD

34 Years of Service

John Boyer, MD

24 Years of Service

Lisa Camara, MD

23 Years of Service

Monique Canonico, 24 Years of Service

Boyuan Cao, MD

25 Years of Service

John Cogan, MD

22 Years of Service

Wayne Fujita, MD

22 Years of Service

Osamu Fukuyama, 39 Years of Service

Gregory Howick, MD

33 Years of Service

Birendra Huja, MD

27 Years of Service

Elliot Kalauawa, MD

39 Years of Service

Carmen Stanko, MD

37 Years of Service

Alan Stein, MD

23 Years of Service

Jared Sugihara, MD

47 Years of Service

ELIZABETH "LIZ" KEALI'IKUA'AINA TAM, M.D. MEMORIAL AWARD

Inaugural Awardee - Reid Ikeda, MD Award Presented Wednesday, May 10th, 2023

Left to Right: Scott Kuwada, MD, AGAF, FACP (Department Interim Chair), Kaeo Tam (Dr. Tam's Brother), Reid Ikeda, MD, FACP (Awardee), Dee-Ann Carpenter, MD (Elizabeth Tam Committee Chair)

Awarded to a JABSOM Department of Medicine faculty member who emulates the passion, grace, leadership, and dedication of Dr. Elizabeth “Liz” Keali‘ikua’āina Tam, who fostered lifelong learning in clinical care, research, and teaching while advocating for cultural humility and equity in medicine in addition to advancing lung health in Hawaii.

Pictured

RESEARCH ENDEAVORS

The Department of Medicine at the University of Hawaii has continued to make significant strides in advancing medical knowledge, improving patient care, and fostering innovative research initiatives throughout the academic year 2022-2023. With a dedicated team of researchers, clinicians, and support staff, we have achieved notable successes in various areas of medical research, education, and community engagement. Our commitment to excellence in healthcare and scientific discovery remains unwavering as we navigate the challenges and opportunities of the ever-evolving landscape of medicine.

Prioritizing the reduction of health disparities among Hawaii’s diverse populations remains a core focus of our department. Through community-based participatory research and initiatives promoting health equity, we are actively engaged in efforts to diminish disparities in healthcare access and enhance health outcomes within underserved communities. Our faculty members within the Department of Medicine are actively participating in two significant research infrastructure and training grants funded by the National Institutes of Health (NIH): the Center for Pacific Innovations, Knowledge, and Opportunities (PIKO) and Ola HAWAII. These grants offer crucial funding and mentorship opportunities for early-career investigators, facilitating their growth and development as researchers.

53 GRANTS 71 PUBLICATIONS $4.31M+ IN GRANT FUNDING RECEIVED THIS ACADEMIC YEAR 2 0 2 22 0 2 3 B Y T H E N U M B E R S D O M R E S E A R C

CENTER FOR PACIFIC INNOVATIONS, KNOWLEDGE, AND OPPORTUNITIES (PIKO)

Through funding from the Institutional Development Award Networks of Clinical and Translational Research (IDeACTR), the Center for PIKO has been established to foster the development and to facilitate the implementation of innovative and evidence-based clinical and translational (CTR) projects aimed at improving the health of Indigenous Pacific People (IPP, defined as Native Hawaiians, Pacific Islanders and Filipinos) and other underserved populations in Hawaii. The PIKO collaborative, which represents a partnership between the University of Hawaii (UH), Hawaii Pacific University (HPU), Chaminade University of Honolulu (CUH), and a large statewide network of 18 practice-based organizations (PBO) and other community-based organizations (CBO), will develop new and leverage existing resources to ensure real-world impact.

OLA HAWAII

Achieving health and wellness for the communities in Hawaii, which suffer disproportionately from genetic, environmental and socio-economic disparities in health and healthcare access, is the rationale for the proposed Research Centers in Minority Institutions (RCMI) Specialized Center. The strategic goal of the Center, named Ola HAWAII, is to grow and support a community of health disparities investigators and collaborators (the “workforce”) to harness the power of diverse thought (the “thinkforce”) to determine the causes of and interventions for health disparities in the Pacific.

The Department of Medicine comprises three primary research units: (1) the Center for Cardiovascular Research, (2) the Hawai‘i Center for AIDS Research, and (3) the Magnetic Resonance Imaging Center. Accomplishments from each of these units over the past year are detailed in the Highlights Section below.

THE CENTER FOR CARDIOVASCULAR RESEARCH

The purpose of the Center for Cardiovascular Research (the CCR) is to train the next generation of cardiovascular investigators and produce a better understanding of cardiac disease. The CCR is a community of scientists that includes the labs of 5 principal investigators on the third floor of the BioScience Building at JABSOM: Drs. William Boisvert, Takashi Matsui, Ralph Shohet, Michelle Tallquist, and Ken Zhang. Several other faculty collaborate with these investigators and utilize resources of the Center including Drs. Olivier LeSaux, Noemi Polgar, Kathryn Shunke, Ben Fogelgren, and Mariana Gerschenson. Each laboratory has distinct areas of focus, Dr. Boisvert the immunology of atherosclerosis, Dr. Matsui signaling and programmed cell death, Dr. Shohet hypoxia and gene delivery, Dr. Tallquist the cardiac fibroblast, and Dr. Zhang the use of induced pluripotent cardiomyocytes to understand cardiac pathology. During fiscal year 2023 important accomplishments included 1. Continued or new grant funding, 2. Publications, and 3. Career progress of our trainees. We also provide echocardiography services to investigators doing cardiovascular research.

John and Andrew are NHLBI K99 MOSAIC scholars, the first at the University. The award supports them as postdocs for two years and then with R01 level funding for three years as they embark on their independent careers.

GRANTS

Highlights include our T32 training grant, the first at the University, which has enabled us, over the past 10 years, to support three graduate students and three postdoctoral fellows every year. During fiscal 2023 we submitted an application for a third 5-year cycle of funding which received an excellent score and will begin in August of 2024. This cycle will be led by Dr. Tallquist with Dr. Shohet serving as deputy director. This grant has also helped to inspire two subsequent successful T32 applications, one a collaboration between the Cancer Center and USC, and the other a collaboration between the School of Nutrition and the Bioinformatics Dept at JABSOM. Dr. Shohet has played an advisory role for both of these. Dr. Tallquist and Shohet also worked closely with Dr. Penner to submit a COBRE grant from Queens Medical Center (not funded) and with Dr. Shepherd to submit a joint COBRE from the Cancer Center and JABSOM (under review). Other important grants have included continued success in funding the independence of our young investigators with two K99-R00 awards, the first to Andrew Knutson, a Native Hawaiian investigator in Dr. Shohet’s lab and a second to John Yap, a Native Hawaiian investigator with Dr. Boisvert, who has the additional distinction

distinction of having completed his undergraduate and graduate education as a quadriplegic trainee. Dr. Matsui obtained HCF funding for his studies of how cell death can propagate down cardiac fibers in infarction. Dr. Zhang obtained funding from Ola Hawaii and has played a key role in recent submissions of the Bioinformatics T32 and COBRE applications. We have had extraordinary success in obtaining predoctoral and postdoctoral awards for our young investigators as well.

PUBLICATIONS

Dr. Tallquist’s group continued to work on cardiac fibrosis, lung development, and analysis of SARS-CoV-2 infection in lung fibrosis and testes dysfunction. This work resulted in three accepted and 4 submitted publications that are currently under review. Dr. Shohet had a publication on using a novel form of gene delivery to deliver Crispr constructs to the liver of mice as well as a joint publication with the GenTAC Registry investigators on vertebral tortuosity in Ehlers-Danlos Syndrome. Dr. Boisvert collaborated with the AIDS group on three publications on cardiovascular risk and with investigators in Spain on two publications relating to the relationship of body fat to atherosclerosis. This also led to a submitted R0-1. Dr. Matsui has continued to work on ferroptosis, publishing both a review article and book chapter in this area.

These leaders of cardiology research met at the 6th annual International Hawaii Cardiovascular Symposium in February 2023. The IHCVS is organized by Dr. Matsui of the CCR and Lorrie Kirshenbaum of the University of Manitoba.

TRAINING

Two of Dr. Tallquist’s students graduated in 2023. Jack Heckl is currently an MD/PhD at Caltech and the Kaiser Permanente School of Medicine. Jasmine Chen, an AHA pre-doctoral fellowship awardee, graduated in December 2023. Dr. Shohet’s graduate student Katie Lee obtained an AHA predoc award for her thesis work on cardiac metabolism and his postdoc April Darrow received both an AHA postdoc award and an Ola Hawaii pilot award for her work on methamphetamine cardiomyopathy. All faculty participate in training of medical students with Drs. Tallquist, Matsui, and Shohet leading PBL groups. Dr. Matsui also organizes the annual International Hawaii Cardiovascular Symposium, that brings investigators from around the world to discuss recent basic advances in heart disease. Dr. Shohet also plays a role in our Cardiology Fellowship, based at Queens Medical Center, where he helps to admit, train, and evaluate clinical fellows.

ADMINISTRATIVE CONTRIBUTIONS

The faculty of the CCR provides a substantial amount of administrative leadership at the School. Dr. Tallquist in particular has served as Cell and Molecular Biology graduate chair, Institutional Biosafety Committee rep, Graduate Council rep, Undergraduate Research Opportunities Council rep, JABSOM Faculty Senate-vice chair, JABSOM curriculum committee, and Senate Executive Committee-vice chair. Dr. Matsui serves as Chair of Anatomy, Physiology, and Biochemistry. Dr. Boisvert serves on the Student Standing and Promotion Committee and has recently become interim Chair of Tropical Medicine. Dr. Shohet, who is the Director of the CCR, served on several tenure and promotion committees and is presently on the Dean Search Advisory Committee.

HAWAI'I CENTER FOR AIDS RESEARCH (HICFA)

From left to right (top): Eduardo Manzano, Dr. Louie Gangcuangco, Nancy Hanks RN, Lorna Nagamine RN, Greg Milne, Dr. Dominic Chow (Director, Clint Spencer Clinic), Dr. Cecilia Shikuma (Director, HICFA), Debbie Ogata-Arakaki RN

From left to right (bottom): Rachel Ouye, Diana Vares-Lum, Cris Milne APRN

The Hawaii Center for AIDS (HICFA is a University of Hawaii Board of Regents’ approved Center of Excellence for HIV research, training and care. HICFA maintains an office, a processing laboratory, and a clinic on the Kakaako campus which doubles both as research clinic space and space for our fee-for-service Clint Spencer HIV clinic. It is involved in the training of graduate students as well as medical students and residents. In research, laboratory research is conducted by 5 Dept of Tropical Medicine faculty affiliated with HICFA and clinical research activities by 3 Dept of Medicine faculty (C Shikuma, D Chow and L Gangcuangco). HICFA maintains an infrastructure for HIV clinical trials (research physicians, clinical research coordinators, processing lab, research pharmacist, research clinic space) and has a long history of providing patients living with HIV in Hawaii access to the latest HIV/AIDS antiretroviral therapy trials. Currently HICFA participates in Gilead’s phase 2 trial assessing the combination of oral weekly Islatravir in combination with Lenacapavir (GS-US-563-6041) to control HIV viremia. Over the past decade, as the health of this population has improved, HICFA’s primary HIV research focus has turned to the chronic age-related complications of HIV and the role of HIV immune activation is this process. We have published extensively on how monocyte/macrophage immune activation instigated by HIV contributes to the higher risk of cardiovascular disease and cognitive impairment in this population. HICFA now intends to address the final frontier of HIV research – that of HIV cure. It is in the early stages of planning a small collaborative early phase clinical trial involving 2 medications, auranofin and buthionine sulfoximine (BSO), intended to leverage the body’s antioxidant pathways to reduce the HIV latent reservoir. A research supply of BSO has been successfully obtained from the National Cancer Institute and a request for FDA IND is planned following re-analysis and re-vialing of BSO.

Front Sitting from left to right (HIV Cured Individuals): Marck Franke, “Dusseldorf Patient”; Adam Castillejo, “The London Patient”; Paul Edmonds,“City of Hope Patient”

Back Standing from left to right: Dr. Louie Gangcuangco (Assistant Professor, Dept of Medicine), Timothy McCormick (Hawaii State Dept of Health), Dr. Thomas J. Hope (Northwestern University) Hawaii to Zero Conference, 2023

HICFA conducts its research and care activities in close collaboration with the community and programs involved in assisting individuals with or at risk for HIV. This includes the State of Hawaii Department of Health Harm Reduction Branch and the state’s Ryan White and STD programs, community physicians and other health clinics involved in HIV care, and various AIDS Service Organizations (ASO) on Oahu and the neighbor islands. In September of 2023, with educational grant funding received from ViiV Healthcare, HICFA organized and held the 5th ‘Hawaii to Zero’ (H20; zero HIV deaths, zero new infections, zero stigma) conference, inviting 200 attendee to the Ala Moana Hotel for a full day of lectures from leaders in the field followed by community dialog on topics ranging from HIV prevention to optimal care of those infected to the possibility of HIV cure. Attendees included researchers, physicians, pharmacists, nurses, case managers and people living with and at risk for HIV from all islands. The highlight of this conference was the attendance of not one but THREE of the total of only 5 individuals in the world known to have been cured of HIV Adam Castillejo, Marc Franke and Paul Edmonds. They shared their individual stories on stage about overcoming HIV and answered questions from the audience about how the cure has impacted them.

HICFA investigators, research associates, and staff at the 2023 Hawaii to Zero Conference: zero new HIV infections, zero HIV-related deaths, and zero stigma

In 2020 with the beginning of the COVID-19 pandemic, HICFA pivoted to take on research on SARS CoV2. Currently, some COVID related research projects HICFA is involved in include the national NIH-funded multi-center RECOVER cohort study (https://recovercovid.org/) designed to study the pathobiology of Long COVID; the 5 year Ola HAWAII project ‘Factors Responsible for the Development of Pulmonary Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) in Hawaii’ (Project MPI G Devendra, Assistant Professor Dept Medicine and J Park, Assistant Professor Dept of Tropical Medicine); the Leahi Foundation grant ‘Role of Anti-idiotype Autoantibodies (AA) directed against ACE2 in the Development of Pulmonary Post-Acute Sequelae of SARS-CoV2 Infection’ (PI C Shikuma); and the Angus Foundation grant ‘COVID-19 Infection in Hawaii’ (PI T Seto/C Shikuma).

Research Resource Cores for 2 research infrastructure https://ola.jabsom.hawaii.edu/) and PIKO (https://piko.jabsom.hawaii.edu/). interested in clinical research projects. Dr. Dominic Director of Ola HAWAII.

HICFA is involved in 2 other initiatives important to promoting research in Hawaii. The Hawaii Clinical Research Network for Health Equity (NIMHD UG3MD08358; MPI C Shikuma, T Seto and V Balaraman) will merge the electronic health records (EHR) of the Queen’s Health System and Hawaii Pacific Health to create the beginnings of a de-identified Hawaiiwide Data Network that can be queried for research questions important to Hawaii and its population. This initial Data Network is anticipated to contain data on approximately 70% of Hawaii’s population. This grant will also initiate 2 projects at a community clinic level, at Kalihi Palama and Waikiki Health, focused on early detection of fatty liver disease utilizing portable FibroScans in our community’s health disparity population (Project PI C Tran, Assistant Professor Medicine) and in our HIV population (Project PI L Gangcuangco, Assistant Professor Medicine).

HICFA’s most recent initiative involves participation in the IDeA State Consortium for Clinical Research Resource Center (ISCORE-RC; NIGMS U24GM150446, PI S Hodder [West Virginia], Hawaii Site PI: C Shikuma). This grant intends to increase clinical trials in IDeA States (of which Hawaii is one) through communication of opportunities, effective marketing, and workforce development. Particularly exciting is the Clinical Research Coordinator training program to be offered by ISCORE-RC which will combine an extensive didactic on-line training program with a preceptor supervised hands-on clinical research experience locally in Hawaii. A certificate will be awarded following a final evaluation process.

UNIVERSITY OF HAWAII MAGNETIC RESONANCE RESE

The University of Hawaii Magne Research Center (UHMRRC) is located Department of Medicine at the John School of Medicine (JABSOM). The access to a 3 Tesla MRI scanner loc Medical Center that has capabilities whole body scans for both clinical purposes. The Center is staffed by faculty V. Andrew Stenger, PhD Rettenmeier, PhD and two staff members Yu, PhD and Steven Bucthal, PhD. members have extensive experience of MRI for research and clinical applications. faculty and staff are located on the UH Medical Tower at the QMC campus.

Drs. Christoph Retteinmeier (left), V. Andrew Stenger (center), and Zidan Yu (right).

There are currently five NIH funded projects, one DOD funded project and one Hawaii Community Foundation project being run in the Center. These projects range from MRI methods development to the study of disease. A large focus is on the use of MRI to image brain function (fMRI) non-invasively in vivo (Stenger, Andres, Grills) for investigating drug addiction as well as mild traumatic brain injury, the latter of which is a collaboration between JABSOM and Tripler Army Medical Center. There are also three studies (Rettenemier, LeMarchand, Lim) for imaging liver fat and fibrosis to probe a range of diseases including NASH and links to cancer and dietary interventions. These involve collaborations between JABSOM, PBRC, and the UHCC. Finally, there is pilot study from the Hawaii Community Foundation (Matsui, JABSOM Department of Anatomy) to use diffusion MRI to probe heart disease.

PUBLICATIONS

FACULTY CLINICAL FACULTY CVD FELLOWS RESIDENTS

1. Acoba JD,HiranoT, Nakasone R, RhoYS.PancreaticcanceramongPacificIslanders:acomprehensiveanalysisofanunderstudiedracial group.EthnHealth.2023Jul;28(5):650-660.doi:10.1080/13557858.2022.2116631.Epub2022Aug28.PMID:36036201.

2. Acoba JD, Sumida K, Berenberg J.OvercomingracialdisparitiesincancerclinicaltrialenrollmentofAsiansandNativeHawaiians. ContempClinTrialsCommun.2022May27;28:100933.doi:10.1016/j.conctc.2022.100933.PMID:36688088;PMCID:PMC9846448.

3. Acoba JD, YinC,MenoM,AbeJ,PaganoI,TamashiroS,FujinagaK,Braun-InglisC,FukuiJ.RacialDisparitiesinPatient-Provider CommunicationDuringTelehealthVisitsVersusFace-to-faceVisitsAmongAsianandNativeHawaiianandOtherPacificIslanderPatientsWith Cancer:Cross-sectionalAnalysis.JMIRCancer.2022Dec9;8(4):e37272.doi:10.2196/37272.PMID:36485021;PMCID:PMC9789492.

4.AsanteI,LuA,MitchellBI, Boisvert WA, Shikuma CM, Chow DC, LouieSG.AlterationsinRenin-AngiotensinSystem(RAS)PeptideLevelsin PatientswithHIV.Metabolites.2022Dec31;13(1):61.doi:10.3390/metabo13010061.PMID:36676986;PMCID:PMC9860813.

5.BennettJP,LiuYE,QuonBK,KellyNN,LeongLT,WongMC,KennedySF, Chow DC,GarberAK,WeissEJ,HeymsfieldSB,ShepherdJA.Threedimensionalopticalbodyshapeandfeaturesimprovepredictionofmetabolicdiseaseriskinadiversesampleofadults.Obesity(SilverSpring). 2022Aug;30(8):1589-1598.doi:10.1002/oby.23470.PMID:35894079;PMCID:PMC9333197.

6. Berg BW. Simulation:past,present,andfuture.ClinExpEmergMed.2023Jun;10(2):125-128.doi:10.15441/ceem.23.044.Epub2023Apr 24.PMID:37095704;PMCID:PMC10350354.

7.BhagavathulaAS,BansilS, Nishimura Y.GoogleTrendsinBreastandCervicalCancerSearchesFrom2008to2021:AnInfodemiologyStudy. Cureus.2023May15;15(5):e39035.doi:10.7759/cureus.39035.PMID:37323300;PMCID:PMC10266303.

8.ChinJM,ChenE,WrightT,BravoRM,NakashimaE, Kiyokawa M,KarasakiK,EstradaP,GhatnekarR,LeeMJ,BartholomewML.Urinedrug screeningonlaboranddelivery.AmJObstetGynecolMFM.2022Nov;4(6):100733.doi:10.1016/j.ajogmf.2022.100733.Epub2022Aug26. PMID:36038068.

9. Chow DC,SaikiKMW,SiriwardhanaC,LozanoGeronaJ,VanapruksS,OgleJ,PremeauxTA,NdhlovuLC,BoisvertWA.Increased TransmigrationofIntermediateMonocytesAssociatedwithAtheroscleroticBurdeninPeoplewithHIVonAntiretroviralTherapy.AIDS.2023 Jun1;37(7):1177-1179.doi:10.1097/QAD.0000000000003534.Epub2023Mar3.PMID:36927653.

10.CobbMS,TaoS,ShorttK,GirgisM,HauptmanJ,SchriewerJ,ChinZ,DorfmanE,CampbellK,HeruthDP, Shohet RV,DawnB,KonorevEA. Smad3promotesadversecardiovascularremodelinganddysfunctionindoxorubicin-treatedhearts.AmJPhysiolHeartCircPhysiol.2022Dec 1;323(6):H1091-H1107.doi:10.1152/ajpheart.00312.2022.Epub2022Oct21.PMID:36269647;PMCID:PMC9678413.

11. Czech T, Shah P, LeeG,WatanabeG,OgasawaraC,NohT.Cerebraltoxoplasmosisinapatientwithcombinedvariableimmunodeficiency. SurgNeurolInt.2022Aug12;13:354.doi:10.25259/SNI5322022.PMID:36128152;PMCID:PMC9479566.

12. Czech T, SugiharaS, Nishimura Y.CharacteristicsofhairlossafterCOVID-19:Asystematicscopingreview.JCosmetDermatol.2022 Sep;21(9):3655-3662.doi:10.1111/jocd.15218.Epub2022Jul19.PMID:35801366;PMCID:PMC9349634.

13.DeanLS, Chow DC,NdhlovuLC, Boisvert WA,ChangSP, Shikuma CM,ParkJ.CharacterizationofCirculatingFibrocytesinPeopleLiving withHIVonStableAntiretroviralTherapy.Immunohorizons.2022Nov1;6(11):760-767.doi:10.4049/immunohorizons.2200085.PMID: 36445359;PMCID:PMC10402248.

14.DeanLS, Devendra G,JiyaromB,SubiaN, Tallquist MD,NerurkarVR,ChangSP, Chow DC, Shikuma CM,ParkJ.Phenotypicalterationof low-densitygranulocytesinpeoplewithpulmonarypost-acutesequalaeofSARS-CoV-2infection.FrontImmunol.2022Dec15;13:1076724. doi:10.3389/fimmu.2022.1076724.Erratumin:FrontImmunol.2023Apr28;14:1209624.PMID:36591237;PMCID:PMC9797994.

15.DiStefanoL,OgburnEL,RamM,ScharfsteinDO,LiT,KhanalP,BakshSN,McBeeN,GruberJ,GildeaMR,ClarkMR,GoldenbergNA,Bennani Y,BrownSM,BuckelWR,ClementME,MulliganMJ,O'HalloranJA,RauseoAM,SelfWH,SemlerMW, Seto T,StoutJE,UlrichRJ,VictoryJ,Bierer BE,HanleyDF,FreilichD.Hydroxychloroquine/chloroquineforthetreatmentofhospitalizedpatientswithCOVID-19:Anindividual participantdatameta-analysis.PLoSOne.2022;17(9):e0273526.doi:10.1371/journal.pone.0273526.eCollection2022.PubMedPMID: 36173983;PubMedCentralPMCID:PMC9521809.

16.DiStefanoL,OgburnEL,RamM,ScharfsteinDO,LiT,KhanalP,BakshSN,McBeeN,GruberJ,GildeaMR,ClarkMR,GoldenbergNA,Bennani Y,BrownSM,BuckelWR,ClementME,MulliganMJ,O'HalloranJA,RauseoAM,SelfWH,SemlerMW, Seto T,StoutJE,UlrichRJ,VictoryJ,Bierer BE,HanleyDF,FreilichD;PandemicResponseCOVID-19ResearchCollaborationPlatformforHCQ/CQPooledAnalyses. Hydroxychloroquine/chloroquineforthetreatmentofhospitalizedpatientswithCOVID-19:Anindividualparticipantdatameta-analysis.PLoS One.2022Sep29;17(9):e0273526.doi:10.1371/journal.pone.0273526.PMID:36173983;PMCID:PMC9521809.

17.DonlonTA,MorrisBJ,MasakiKH,ChenR,DavyPMC,KallianpurKJ, Nakagawa K,OwensJB,WillcoxDC,AllsoppRC,WillcoxBJ.FOXO3,a ResilienceGene:ImpactonLifespan,Healthspan,andDeathspan.JGerontolABiolSciMedSci.2022Aug12;77(8):1479-1484.doi: 10.1093/gerona/glac132.PMID:35960854;PMCID:PMC9373965.

18. Estaris J,BansilS, Nishimura Y.Steroid-ResponsiveEncephalopathyAssociatedWithAutoimmuneThyroiditisMasqueradingSepsis. Cureus.2023May10;15(5):e38826.doi:10.7759/cureus.38826.PMID:37303426;PMCID:PMC10252151.

19. Fujii-Lau LL,ThosaniNC,Al-HaddadM, Acoba J,WrayCJ,ZvavanjanjaR,AmateauSK,BuxbaumJL,WaniS,CalderwoodAH,ChalhoubJM, Coelho-PrabhuN,DesaiM,ElhanafiSE,FishmanDS,ForbesN,JamilLH,JueTL,KohliDR,KwonRS,LawJK,LeeJK,MachicadoJD,MaryaNB, PawaS,RuanW,SawhneyMS,ShethSG,StormA,ThiruvengadamNR,QumseyaBJ;(ASGEStandardsofPracticeCommitteeChair[20202023]).AmericanSocietyforGastrointestinalEndoscopyguidelineonroleofendoscopyinthediagnosisofmalignancyinbiliarystricturesof undeterminedetiology:methodologyandreviewofevidence.GastrointestEndosc.2023Nov;98(5):694-712.e8.doi:0.1016/j.gie.2023.06.007. Epub2023Jun10.PMID:37307901.

20. Gangcuangco LMA,RivasT,BasnetA,RyuDY,QaiserM,UsmanR,CostalesVC.Factorsassociatedwithcolorectalcancerscreening adherenceandtheimpactofCOVID-19onscreeningpatternsinConnecticut,USA.InternEmergMed.2022Nov;17(8):2229-2235.doi: 10.1007/s11739-022-03053-2.Epub2022Aug3.PMID:35922730;PMCID:PMC9362104.

21. Gangcuangco LMA,EustaquioPC.TheStateoftheHIVEpidemicinthePhilippines:ProgressandChallengesin2023.TropMedInfectDis. 2023Apr30;8(5):258.doi:10.3390/tropicalmed8050258.PMID:37235306;PMCID:PMC10224495.

22.GiannakopoulosS,StrangeDP,JiyaromB,AbdelaalO,BradshawAW,NerurkarVR,WardMA,BakseJ,YapJ,VanapruksS, Boisvert WA, Tallquist MD, Shikuma C,Sadri-ArdekaniH,ClappP,MurphySV,VermaS.InvitroevidenceagainstproductiveSARS-CoV-2infectionof humantesticularcells:Bystandereffectsofinfectionmediatetesticularinjury.PLoSPathog.2023May18;19(5):e1011409.doi: 10.1371/journal.ppat.1011409.PMID:37200377;PMCID:PMC10231791.

23. Gozun M, Keitoku K, Kimura N, Sawada H, Pham A, Yeo J,HagiyaH, Nishimura Y. Cefepime-inducedneurotoxicity:systematicreview.J AntimicrobChemother.2022Oct28;77(11):2908-2921.doi:10.1093/jac/dkac271.PMID:35971666.

24.HaG,KwongK,TanakaB, Nishimura Y, Chong C.ArePatientswithHHV-8AssociatedCastlemanDiseaseSuccessfullyTreatedwith RituximabatRiskofSubsequentlyDevelopingHHV-8Negative(Idiopathic)CastlemanDisease?EurJCaseRepInternMed.2023Jun 20;10(7):003904.doi:10.12890/2023003904.PMID:37455698;PMCID:PMC10348438.

25.HedgesJR, Chow DC,FogelgrenB,BraunKL,TsarkJU,OrdinadoS,BerryMJ,YanagiharaR,MokuauN.HealthDisparitiesInvestigator DevelopmentthroughaTeam-SciencePilotProjectsProgram.IntJEnvironResPublicHealth.2023Mar30;20(7):5336.doi: 10.3390/ijerph20075336.PMID:37047951;PMCID:PMC10094603.

26.HiramiY,NishimuraMF,UrataT,MorimotoM,MaekawaY,YoshinoT, Nishimura Y, SatoY.ComparisonofserumsIL-2RandLDHlevelsin patientswithintravascularlargeB-celllymphomaandpatientswithadvancedstagediffuselargeB-celllymphoma.JClinExpHematop.2023 Mar28;63(1):25-31.doi:10.3960/jslrt.22043.Epub2023Mar26.PMID:36843068;PMCID:PMC10158718.

27.IngCT,ClemensB,AhnHJ,KaholokulaJK,HovmandPS, Seto TB,NovotnyR.FoodInsecurityandBloodPressureinaMultiethnic Population.IntJEnvironResPublicHealth.2023Jun28;20(13).doi:10.3390/ijerph20136242.PubMedPMID:37444090;PubMedCentral PMCID:PMC10341426.

28.JujoS,SakkaBI,Lee-JayaramJJ,KataokaA,IzumoM,KusunoseK,NakahiraA,OikawaS,KataokaY, Berg BW.Medicalstudentmediumtermskillretentionfollowingcardiacpoint-of-careultrasoundtrainingbasedontheAmericanSocietyofEchocardiographycurriculum framework.CardiovascUltrasound.2022Oct12;20(1):26.doi:10.1186/s12947-022-00296-z.PMID:36224597;PMCID:PMC9554392.

29.KandahF,DeolT, Dhruva P,ChandlerZ,MusaT,VelardeG.ACaseofPostpartumTakotsubo(Stress)Cardiomyopathy.CaseRepCardiol. 2022Aug4;2022:4739742.doi:10.1155/2022/4739742.PMID:35967747;PMCID:PMC9371808.

30.KhawajaM,QadeerYK,SiddiquiR,CheluMG, Aiumtrakul N,PickettJK,BrugadaR,BrugadaJ,BrugadaP,KrittanawongC.Brugada SyndromewithinAsianPopulations:State-of-the-ArtReview. Cardiogenetics.2023;13(2):61-74.doi:10.3390/cardiogenetics13020007.

31. Kiyokawa M,QuattlebaumTHN.ImplicationsforaSystemofCareinHawai'i:PrimaryCareIntegrationofSubstanceUseDisorder Treatment.HawaiiJHealthSocWelf.2022Dec;81(12Suppl3):62-68.PMID:36660279;PMCID:PMC9783814.

32. Kozai L, Nishimura Y. Clinicalcharacteristicsofbluerubberblebnevussyndromeinadults:systematicscopingreview.ScandJ Gastroenterol.2023Jul-Dec;58(10):1108-1114.doi:10.1080/00365521.2023.2214263.Epub2023May21.PMID:37211745.

33. Kozai L, Tan A, Nebrejas KE, Warashina C, Nishimura Y.CollagenousGastritisIsanUnderdiagnosedCauseofAnemiaandAbdominal Pain:SystematicScopingReview.DigDisSci.2023Jul;68(7):3103-3114.doi:10.1007/s10620-023-07938-w.Epub2023Apr6.PMID: 37022603.

34.KreidiehO,VarleyAL,RomeroJ, Singh D,SilversteinJ,ThosaniA,VarosyP,HebsurS,GodfreyBE,SchrappeG,JusticeL,ZeiPC,OsorioJ. PracticePatternsofOperatorsParticipatingintheReal-WorldExperienceofCatheterAblationforTreatmentofSymptomaticParoxysmaland PersistentAtrialFibrillation(REAL-AF)Registry.JIntervCardElectrophysiol.2022Nov;65(2):429-440.doi:10.1007/s10840-022-01205-0. Epub2022Apr19.PMID:35438393.

35.Kuniyoshi J,KwockM,SilangcruzK, Techasatian W, Nishimura Y.THECHATTERJEEPHENOMENON:ADEMONSTRATIONOFCARDIAC MEMORYINPACEDRHYTHMS.EurJCaseRepInternMed.2023Mar3;10(3):003798.doi:10.12890/2023003798.PMID:36969518;PMCID: PMC10035617.

36.KuwabaraJT,HaraA,BhutadaS,GojanovichGS,ChenJ,HokutanK,ShettigarV,LeeAY,DeAngeloLP,HecklJR,JahansoozJR,TacdolDK,ZioloMT,Apte SS, Tallquist MD.ConsequencesofPDGFRα+fibroblastreductioninadultmurinehearts.Elife.2022Sep23;11:e69854.doi: 10.7554/eLife.69854.PMID:36149056;PMCID:PMC9576271.

37.KuwabaraJT,HaraA,HecklJR,PenaB,BhutadaS,DeMarisR,IveyMJ,DeAngeloLP,LiuX,ParkJ,JahansoozJR,MestroniL,McKinseyTA, ApteSS, Tallquist MD.Regulationofextracellularmatrixcompositionbyfibroblastsduringperinatalcardiacmaturation.JMolCellCardiol. 2022Aug;169:84-95.doi:10.1016/j.yjmcc.2022.05.003.Epub2022May13.PMID:35569524;PMCID:PMC10149041.

38.KweeSA,WongLL,LudemaC,DengCK,TairaD, Seto T,LandsittelD.TargetTrialEmulation:ADesignToolforCancerClinicalTrials.JCO ClinCancerInform.2023Jan;7:e2200140.doi:10.1200/CCI.22.00140.PubMedPMID:36608311;PubMedCentralPMCID:PMC10166475.

39.LeeAY, Kuwada SK.Useofanover-the-scopeclipinmanagingadultanastomoticulcerbleeding.JSurgCaseRep.2023Jun 30;2023(6):rjad350.doi:10.1093/jscr/rjad350.PMID:37397066;PMCID:PMC10314710.

40.LuuJM,WeiJ,ShufeltCL,AsifA, Tjoe B,TheriotP,BaireyMerzCN.ClinicalPracticeVariationsintheManagementofIschemiaWithNo ObstructiveCoronaryArteryDisease.JAmHeartAssoc.2022Oct4;11(19):e022573.doi:10.1161/JAHA.121.022573.Epub2022Sep29. PMID:36172938;PMCID:PMC9673699.

41.MahfouzR,DouglasMF,ObeidatAE,DarweeshM,MansourMM, Shah P,AldiabatM,AljabiriY,FishmanA.ImpactofAtrialFibrillationon PatientsWithInflammatoryBowelDiseaseAdmittedforColectomy.Cureus.2022Aug10;14(8):e27849.doi:10.7759/cureus.27849.PMID: 36110442;PMCID:PMC9462059.

42.MiyoshiT,IdaH, Nishimura Y,AkoS,OtsukaF.EffectsofYogaandMindfulnessProgramsonSelf-CompassioninMedicalProfessionals duringtheCOVID-19Pandemic:AnInterventionStudy.IntJEnvironResPublicHealth.2022Sep30;19(19):12523.doi: 10.3390/ijerph191912523.PMID:36231820;PMCID:PMC9566664.

43. Nakagawa K,ChenR,GreenbergSM,RossGW,WillcoxBJ,DonlonTA,AllsoppRC,WillcoxDC,MorrisBJ,MasakiKH.ForkheadboxO3 longevitygenotypemayattenuatetheimpactofhypertensiononriskofintracerebralhaemorrhage.JHypertens.2022Nov1;40(11):22302235.doi:10.1097/HJH.0000000000003249.Epub2022Aug3.PMID:35943066;PMCID:PMC9553272.

44.NguyenTB,LacQ,AbdiL, Banerjee D,DengY,ZhangY.Harsheningstemcellresearchandprecisionmedicine:Thestatesofhuman pluripotentcellsstemcellrepositorydiversity,andracialandsexdifferencesintranscriptomes.FrontCellDevBiol.2023Jan4;10:1071243. doi:10.3389/fcell.2022.1071243.PMID:36684445;PMCID:PMC9848738.

45.NishikoriA,NishimuraMF, Nishimura Y,OtsukaF,MaehamaK,OhsawaK,MomoseS,NakamuraN,SatoY.IdiopathicPlasmacytic LymphadenopathyFormsanIndependentSubtypeofIdiopathicMulticentricCastlemanDisease.IntJMolSci.2022Sep7;23(18):10301.doi: 10.3390/ijms231810301.PMID:36142213;PMCID:PMC9499480.

46. Nishimura Y, Choi H,ColganB,KistlerH,MercadoF.Currentevidenceandclinicalutilityofphenobarbitalforalcoholwithdrawal syndrome.EurJInternMed.2023Jun;112:52-61.doi:10.1016/j.ejim.2023.03.006.Epub2023Mar21.PMID:36935249.

47. Nishimura Y. Daptomycin-RelatedRhabdomyolysisComplicatedbySevereHyperkalemiaandAcuteKidneyInjury.Cureus.2022Sep 29;14(9):e29764.doi:10.7759/cureus.29764.PMID:36324366;PMCID:PMC9617813.

48. Nishimura Y.PrimaryCare,Burnout,andPatientSafety:WaytoEliminateAvoidableHarm.IntJEnvironResPublicHealth.2022Aug 16;19(16):10112.doi:10.3390/ijerph191610112.PMID:36011747;PMCID:PMC9408659.

49.ObeidatA,SilangcruzK, Kozai L,WienE,FujiwaraY, Nishimura Y.ClinicalCharacteristicsandOutcomesofGastritisAssociatedWith ImmuneCheckpointInhibitors:ScopingReview.JImmunother.2022Oct1;45(8):363-369.doi:10.1097/CJI.0000000000000435.Epub2022 Aug16.PMID:35972801.

50.PanD, Li C,WuS,MaL.SurgicalTreatment&Long-termFollowUpofGiantSphericalCoronaryArteryAneurysmwithFistulatoLeft Ventricle:ACaseReport.HeartSurgForum.2022Sep28;25(5):E674-E675.doi:10.1532/hsf.4959.PMID:36317899.

51.ParkJ,DeanLS,JiyaromB, Gangcuangco LM, Shah P,AwamuraT,ChingLL,NerurkarVR, Chow DC,IgnoF, Shikuma CM, Devendra G. ElevatedcirculatingmonocytesandmonocyteactivationinCOVID-19convalescentindividuals.FrontImmunol2023Apr3;14:1151780.doi: 10.3389/fimmu.2023.1151780.eCollection2023.PMID:37077911PMCID:PMC10106598.

52.RECOVERConsortium(Chow D).DevelopmentofaDefinitionofPostacuteSequelaeofSARS-CoV-2Infection.JAMA.2023Jun 13;329(22):1934-1946.doi:10.1001/jama.2023.8823.PMID:37278994;PMCID:PMC10214179.

53.RECOVERConsortium(D Chow).ResearchingCOVIDtoEnhanceRecovery(RECOVER)adultstudyprotocol:Rationale,objectives,and design.PLoSOne.2023Jun23;18(6):e0286297.doi:10.1371/journal.pone.0286297.eCollection2023.PMID:37352211.

54. Sawada H, Czech T, Silangcruz K, Kozai L,ObeidatA,WienEA,NishimuraMF,NishikoriA,SatoY, Nishimura Y.Clinicopathological characteristicsofgastricIgG4-relateddisease:Systematicscopingreview.JGastroenterolHepatol.2022Oct;37(10):1865-1872.doi: 10.1111/jgh.15980.Epub2022Aug21.PMID:35949057.

55.SentellTL,AgnerJL,DavisJ,MannemS, Seto TB,ValenteTW,VawerM,TairaDA.Socialnetworksinpatientshospitalizedwithpreventable conditionsforheartdiseaseanddiabetesinHawai'ibyhealthliteracy.ChronicIlln.2022Sep;18(3):517-531.doi: 10.1177/1742395320987892.Epub2021Jan26.PMID:33497289.

56.SetoBK,NishizakiL,AkakaG,KimuraJA, Seto TB.DifferencesinCOVID-19HospitalizationsbySelf-ReportedRaceandEthnicityina HospitalinHonolulu,Hawaii.PrevChronicDis.2022Nov17;19:E72.doi:10.5888/pcd19.220114.PMID:36395004;PMCID:PMC9673976.

57. Shah P,BenaventeK,YeoJ, Czech T, Techasatian W, Daoud EG. DiaphragmaticPacinginSpinalCordInjury.JMech Vent2022;3(2):63-71.doi:10.53097/JMV.10049.

58. Shah P, Chock M, Nishimura Y,etal.Ciprofloxacin-inducedcrystalnephropathyandallergicinterstitialnephritis:CasereportandReview Ofliterature.AIMClinicalCases.2022;1:e220243.doi:10.7326/aimcc.2022.0243.

59.TakashikiR,KomatsuJ,NowickiM,MoritokiY,OkazakiM,OhshimaS,HasegawaH,NomuraK,OuchiG, Berg BW,ShirakawaH,Nakayama K,TakahashiN.Improvingperformanceandself-efficacyofnovicenursesusinghybridsimulation-basedmasterylearning.JpnJNursSci.2023 Apr;20(2):e12519.doi:10.1111/jjns.12519.Epub2022Nov21.PMID:36410049.

60. Tanariyakul M, Chang B, Keitoku K,SuM,HagiyaH, Nishimura Y.ClinicalCharacteristicsofStrongyloidiasisduringtheCOVID-19 Pandemic:SystematicScopingReview.AmJTropMedHyg.2023Mar20;108(5):901-905.doi:10.4269/ajtmh.22-0671.PMID:36940666; PMCID:PMC10160902.

61.Techasatian W, Gozun M,MoriharaC, Pham A, Benavente K, Nagamine T, Nishimura Y. Hamartomaofmaturecardiacmyocytes: systematicreview.CardiovascPathol.2023Jul-Aug;65:107538.doi:10.1016/j.carpath.2023.107538.Epub2023Apr7.PMID:37031829.

62.TokumasuK, Nishimura Y,SakamotoY,ObikaM,KataokaH,OtsukaF.DifferencesinStressPerceptionofMedicalStudentsDependingon In-PersonCommunicationandOnlineCommunicationduringtheCOVID-19Pandemic:AJapaneseCross-SectionalSurvey.IntJEnvironRes PublicHealth.2023Jan15;20(2):1579.doi:10.3390/ijerph20021579.PMID:36674333;PMCID:PMC9865011.

63.UmbarkarP,TousifS,SinghAP,AndersonJC,ZhangQ, Tallquist MD,WoodgettJ,LalH.FibroblastGSK-3αPromotesFibrosisviaRAF-MEKERKPathwayintheInjuredHeart.CircRes.2022Sep16;131(7):620-636.doi:10.1161/CIRCRESAHA.122.321431.Epub2022Sep2.PMID: 36052698;PMCID:PMC9481711.

64.UmeiN,NishimuraM,IchibaS,SakamotoA, Berg BW. TheNeedforanAdultIntensiveCareUnitBootCampforResidentsandFellows:A Cross-SectionalSurveyamongIntensiveCareUnitDirectors.JNipponMedSch.2022Aug27;89(4):443-453.doi: 10.1272/jnms.JNMS.202289-412.Epub2022May30.PMID:35644548.

65.Veillet-ChowdhuryM,DabbaghGS,BentonSMJr,HillAM,LeeJH,SingletonMJ,FazioGP,HarveyJE,SamadyH, Singh D,KhanjiMY, NazarianS,PuglieseF,Obeng-GyimahE,SchulerBT,ChahalCAA.CT-GuidedDirectCurrentCardioversionforAtrialArrhythmiasDuringthe COVID-19Pandemic.JACCCardiovascImaging.2023Jan;16(1):135-137.doi:10.1016/j.jcmg.2022.08.009.Epub2022Oct19.PMID: 36599561.

66. Vo K, Nishimura Y,YokoyamaJ, Wasko A, Miyake T, Vu K, Zhang J, Pino Moreno J, Banerjee D,KimL, Chong C.Eosinophilic MyocarditisPresentingasCardiacTamponade:ADiagnosticChallenge.EurJCaseRepInternMed.2022Sep20;9(9):003564.doi: 10.12890/2022003564.PMID:36299841;PMCID:PMC9586496.

67.WielandJ,QuinnK,StengerK,ChengS, Acoba J.PatientUnderstandingofOncologicRadiologyReports:IsAccesstoElectronicMedical RecordsHelpful?JCancerEduc.2023Jun;38(3):895-899.doi:10.1007/s13187-022-02204-5.Epub2022Aug19.PMID:35984630.

68.YagiMS,NumanoiS,MatsumotoY,MasudaM, Berg BW.Factorsfacilitatingindependenttrainingusinghumanpatientsimulatorsfor nursingstudents,JournalofClinicalSimulationResearch(Japan),2022,Volume9,Pages3-11.doi:10.57441/jcsr.9.0_3.

69.YeY,NocheRB,SzejkoN,BothCP,AcostaJN,LeasureAC, Brown SC,ShethKN,GillTM,ZhaoH,FalconeGJ.Agenome-wideassociation studyoffrailtyidentifiessignificantgeneticcorrelationwithneuropsychiatric,cardiovascular,andinflammationpathways.Geroscience.2023 Aug;45(4):2511-2523.doi:10.1007/s11357-023-00771-z.Epub2023Mar16.PMID:36928559;PMCID:PMC10651618.

70. Yeo J, Shah P, Keitoku K, Gozun M,FranckCL, Daoud EG.MechanicalpowerinAVM-2versusconventionalventilation modesinvariousARDSlungmodels:Abenchstudy.JMechVent2022;3(3):110-122.doi:10.53097/JMV.10056.

71.YuZ,ChenS,TangZ,TangY,LingZ,WangH,GongT,GaoZ, Devendra G,HuangG,ChenW,DengY.Mitochondria-derivedsmallRNAsas diagnosticbiomarkersinlungcancerpatientsthroughanovelratio-basedexpressionanalysismethodology.GenesDis.2022Aug 7;10(3):1055-1061.doi:10.1016/j.gendis.2022.07.013.PMID:37396544;PMCID:PMC10308114.

GRANTS

CLINICAL FACULTY

1. Administrative Supplements to Enhance Inclusion of Native Hawaiian/Other Pacific Islander Populations in Minority Health and Health Disparities Research. PI: Chow D. FundedbyNIH;$125,000awardedon9/1/2021;projectperiod9/1/21-8/30/2024.

2. American Lung Association of Hawaii and Leahi Fund Endowed Chair in Respiratory Health (research). Director: Ikeda R. Funded locally;$40,000awardedon9/23/2022;projectperiod9/24/2022-6/30/2024.

3. A Phase 2 Randomized, Open-Label, Active-Controlled Study Evaluating the Safety and Efficacy of an Oral Weekly Regimen of Islatravir in Combination With Lenacapavir in Virologically Suppressed… (non-research). PI: Shikuma C. FundedbyGileadSciences, Inc.;$4,10,416awardedon4/28/2023;projectperiod3/16/2023-11/30/2026.

4. Association of microbiome on blood pressure and hypertension in HIV participants on suppressive antiretroviral therapy (research). PI: Chow D. Locallyfunded;$30,000awardedon5/1/2020;projectperiod5/1/2020-4/30/2023.

5. Cardiovascular Complications of HIV (HRSA). Co-PI: Seidel Tallquist M. FundedbyNIH;$800,000awardedon8/18/2018;project period8/18/2018-6/30/2023.

6. Cell-to-cell death along myofibers in ischemic heart disease (research). Other: Rettenmeier C. Fundedlocally;$60,000awardedon 7/1/2022;projectperiod7/1/2022-1/1/2024.

7. COBRE-Diabetes in NCE (research). Pilot Project Coordinator: Shohet R. FundedbyNIH;$1,500,000awardedon8/1/2012;project period8/1/2012-7/31/2022.

8. COBRE-Diabetes Pilot Project (research). PI: Brown S. FundedbyUH;$50,000awardedon6/20/2022;projectperiod8/1/20237/31/2024.

9. COVID-19 Infection in Hawaii (research). Co-PI: Chow D. Localfunding;$150,000awardedon9/1/2021;projectperiod10/1/20223/30/2024.

10. Creative Pedagogy Award (research). PI: Miles J. FundedbyUH;$3,000awardedon4/30/2023;projectperiod7/1/2023-6/30/2024.

11. Development and Validation of a Novel Tool to Assess Sodium Intake for Heart Disease Prevention in a Multiethnic Population (research). Other: Seto T. Fundedlocally;$59,190awardedon7/1/2022;projectperiod7/1/2022-1/1/2024.

12. Directed evolution of a sequence-specific targeting technology… (research). Other: Shohet R. FundedbyNIH;awardedon4/1/2021; projectperiod4/1/2021-3/31/2025.

13. Effect of Immulina Supplements on Inflammatory Biomarkers Correlated With Clinical Symptoms in Patients With Long COVID (PASC) (research). PI: Shikuma C. FundedbytheUniversityofMississippi;$12,500awardedon1/17/2024;projectperiod12/1/20227/31/2023.

14. Effects of Intermittent Energy Restriction on Intra-Abdominal Fat and the Gut Microbiome: A Randomized Trial (research). Other: Stenger, A. PI:LeMerchand.FundedbyNIH,$2,500,000awardedon9/21/2021;projectperiod9/21/2021-8/31/2026.

15. Evaluation of treatment predictors reflecting beta-catenin activation in hepatocellular carcinoma (research). Other: Rettenmeier C. FundedbyNIH;$2,600,000awardedon6/24/2021;projectperiod07/01/2021-06/30/2026.

16. Facilitators and barriers to implementation of a pilot methamphetamine treatment program at a Level I trauma center (research). Co-I: Kiyokawa M. Fundedlocally.$14,575awardedon6/13/2022;projectperiod7/1/2022-1/1/2024.

17. Factors Responsible for the Development of Pulmonary Post-Acute Sequelae of SARS-CoV-2 Infection (PPASC) in Hawaii (research). PI: Devendra G. FundedbyNIH;$300,000awardedon9/1/2022;projectperiod9/1/2022-5/31/2027.

18. Hawai’i Clinical Research Network for Health Equity (research). PI: Shikuma C. Co-PI: Seto T. Other: Gangcuangco L. Fundedby NIH;$3,105,250awardedon9/23/2022;projectperiod9/24/2022-6/30/2024.

19. Hawai’i Health Equity Research and Outreach Network (HAWAI’I HERON) (research). Co-PI: Seto T. FundedbyFDA;$550,000 awardedon6/1/2023;projectperiod6/1/2023-5/31/2025.

20. Hawaii Interdisciplinary Mentored Career Development in HIV Co-Morbidities (training). Co-PI: Seto T. FundedbyNIH;$1,558,000 awardedon8/1/2018projectperiod8/1/2018-6/30/2024.

21. Hawaii Pacific Islands Mammography Registry (research). Other: Seto T. FundedbyNIH;$165,360awardedon4/1/2023;project period4/1/2023-3/31/2028.

22. Hawaii to Zero (non-research). PI: Shikuma C. FundedbyViivhealthcare;$94,954awardedon5/4/2023;projectperiod3/24/202311/30/2023.

23. Hispanic, black and pacific islander perspectives on COVID-19 outreach strategies and patient centered outcomes (HEAR US) (research). Co-PI: Seto T. FundedbyFDA;$969,000awardedon4/1/2022;projectperiod4/1/2022-3/31/2024.

24. Integrative Center for Precision Nutrition and Human Health (research). Other: Rettenmeier C, Stenger VA. PI:Berry.Fundedby NIH;$7,500,000awardedon12/01/2021;projectperiod12/01/2021-11/30/2026.

25. John & Violet Kay Summer Research Fellowship. Other: Chow D. FundedbyIolaniHighSchoolStudentSummerFellowshipprogram; $2,000awardedon6/1/2021;projectperiod6/1/2021-8/21/2023.

26. Kinā’ōle: Expanding Telestroke Coverage to the Prehospital Setting in Hawaii’s Rural Communities HRSA Telemedicine Network Grant Program (TNGP). PI: Koenig M. FundedbyHRSA;$1,200,000awarded;projectperiod2019-2023.

27. Kuakini Reimbursement Agreement (non-research). PI: Kuwada S. $137,636awardedon7/29/2022;projectperiod7/1/20226/30/2023.

28. Lesion Composition and Quantitative Imaging Analysis on Breast Cancer Diagnosis (research). Other: Seto T. FundedbyNIH; $79,000awardedon8/9/2021;projectperiod8/9/2021-7/31/2026.

29. Longitudinal Study of Early NAFLD Progression and the Gut Microbiome in Asian Americans, Native Hawaiians and Whites (research). Other: Rettenmeier C. FundedbyNIH;$3,342,000awardedon9/26/2022;projectperiod9/26/2022-6/30/2027.

30. Monocytes and macrophages in HIV cardiovascular risk (research). PI: Boisvert W. FundedbyNIH.Projectperiod2017-2023.

31. Mouse Model of SARSCoV2 (research). PI: Seidel Tallquist M. Fundedlocally;$50,000awardedon12/1/2020;projectperiod 12/1/2020-6/30/2023.

32. Ola Hawaii Post Covid Pulmonary Long Covid Study (research). Other: Yess J. FundedbyNIH;awardedon9/1/2022;projectperiod 9/1/2022-9/1/2024.

33. Ola HAWAII Team-Science Pilot Projects Program Native Hawaiian Experiences and Perceptions of Primary Care at Queen Emma Clinic. PI: Yess, J.

34. Pacific Basin Telehealth Resource Center (PBTRC) Contributor – UH Telecommunications and Social Informatics (TASI). Other: Berg, B. PI:Okamura,N.2022.

35. Pacific Simulators (PACSIM) Contributor (HRSA). Other: Berg, B. PI:Withey,K.Projectperiod2021-2022.

36. Perceptions of Genomic Medicine and Technology among Native Hawaiian Patients Enrolled in a Longitudinal Healthcare Engagement Program (research). PI: Brown, S. Other: Yess, J. FundedbyHawaiiCommunityFoundation(HCF)MedicalResearch;$60,000 awardedon6/20/2022;projectperiod10/1/2022-3/30/2024.

37. Pacific AIDS Education and Training Center (PAETC)-Hawaii and US-Affiliated Pacific Islands (HRSA). Co-PI: Gangcuangco L. FundedbyHRSA;$186,338awardedon9/26/2023;projectperiod7/1/2023-6/30/2024.

38. Phase II study of TSR-022 in combination with TSR-042 for the treatment of advanced hepatocellular carcinoma (research). PI: Acoba JD. FundedbyGlaxoSmithKlineplc(GSK);$533,966awardedon4/9/2018;projectperiod4/9/2018-4/9/2025.

39. Radial Echo Volumar Imaging Grant (research). PI: Stenger, VA. Other: Rettenmeier C. FundedbyNIH;$900,000awardedon 7/9/2020;projectperiod07/15/2020-03/31/2024.

40. Regulation of Metabolism by PKM2 in the Mouse Heart (non-research). PI: Shohet R. FundedbyAHA;$137,636awardedon 7/29/2022;projectperiod7/1/2022-6/30/2023.

41. Role of Anti-Idiotype Autoantibodies (AA) Directed Against ACE2 in the Development of Pulmonary Post-Acute Sequelae of SARSCoV2 Infection (PASC) (research). PI: Shikuma C. FundedbyLeahiFoundation(HCF)$60,000awardedon7/26/2023;projectperiod 12/1/2022-6/1/2024.

42. Role of Fibroblasts in Cardiovascular Inflammation (research). PI: Seidel Tallquist, M. FundedbyNIH;$275,000awardedon 8/18/20218;projectperiod2/1/2021-1/31/2023.

43. Role of Lipofibroblast in Alveolar Development (research). PI: Seidel Tallquist, M. FundedbyNIH;$2,000,000awardedon2/1/2021; projectperiod08/18/2018-06/30/2023.

44. Role of Monocyte/Macrophage in HIV-related Cardiovascular Risk (research). PI: Chow, D. FundedbyNIH;$1,200,000awardedon 9/1/2018;projectperiod9/1/2018-8/30/2022.

45. Queen Emma Land Company (QELC) Reimbursement Agreement (non-research). PI: Kuwada, S. $613,439awardedon8/26/2022. 7/1/2022-6/30/2023.

46. Queen’s Medical Center (QMC) Reimbursement Agreement (non-research). PI: Kuwada, S. $47,112awardedon8/2/2022.7/1/2022 -6/30/2023.

47. Ryan White Part B Care Act grants (HRSA). PI: Chow, D. Co-PI: Gangcuangco, L. Other: Lu D, Shikuma C, Shiramizu, B. $300,000 awardedon1/1/2021;projectperiod1/1/2023-12/31/2023.

48. Training in Cardiovascular Research at the University of Hawaii (HRSA). PI: Shohet, R. Other: Seidel Tallquist, M. FundedbyNIH; $500,000awardedon8/1/2018;projectperiod8/1/2018-7/31/2023.

49. Transformational Project Award - Lipid metabolism in the endothelium (research). PI: Boisvert, W. FundedbyAHA.Projectperiod 2020-2023.

50. Ultrasound-directed gene therapy for Hemophilia B (research). PI: Shohet, R. FundedbyChunFoundation;$24,000awardedon 6/1/2023;projectperiod7/1/2023-6/30/2024.

51. University of Hawai’i Cancer Center Seed Grant (research). PI: Kuwada, S. FundedbyUH;$17,000awardedon4/1/2022;project period4/1/2022-6/30/2023.

52. Unpacking the Mechanisms of Disparities for HIV-Related Hypertension in African American and Asian Pacific American Men who have Sex with Men (MSM) Study (research). Co-PI: Chow, D. FundedbyNIH;$2,100,00awardedon9/1/2018;projectperiod9/1/20188/30/2022.

53. QI and Population Health Initiatives - Native Hawaiian Population. Other: Yess, J.

MAHALO TO OUR DONORS

We are deeply grateful for the support received over the past year via the Department of Medicine Enhancement Fund, the Elizabeth Tam Memorial Fund, and other University of Hawai’i Foundation Accounts. Private, often anonymous donations have helped us to fulfill our departmental mission in multiple ways, including:

Faculty development

Research endeavors

Neighbor island outreach

Resident and medical student academic development

Staff professional development

Clinical Faculty recognition

Visiting professorships

To donate or learn more about our work, please contact Executive Director of Development, Julie Inouye at (808) 692-0873 or Julie.Inouye@uhfoundation.org