UH Department of Medicine Annual Report 2022-2023

2022-2023

UH DEPARTMENT OF MEDICINE

ANNUAL REPORT

TABLE OF

CONTENTS ALOHA FROM THE CHAIR. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1 OUR FACULTY DEPARTMENT LEADERSHIP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 FACULTY BY DIVISION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3 FACULTY HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .8 DIVISION HIGHLIGHTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 MEDICAL STUDENT EDUCATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 GRADUATE MEDICAL EDUCATION UNIVERSITY OF HAWAI'I INTERNAL MEDICINE RESIDENCY PROGRAM (UHIMRP) . . . . . . . . . . . . 23 CARDIOVASCULAR DISEASE (CVD) FELLOWSHIP PROGRAM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 COMMUNITY ENGAGEMENT AMERICAN COLLEGE OF PHYSICIANS (ACP) HAWAI'I CHAPTER . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 PAPAKOLEA HEALTH FAIR . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 AWARDS CLINICAL FACULTY SERVICE AWARDS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 ELIZABETH "LIZ" KEALI'IKUA'AINA TAM, M.D. MEMORIAL AWARD . . . . . . . . . . . . . . . . . . . . . . . . . 35 RESEARCH ENDEAVORS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36 CENTER FOR CARDIOVASCULAR RESEARCH (CCR) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 HAWAI'I CENTER FOR AIDS (HICFA) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 UNIVERSITY OF HAWAI'I MAGNETIC RESONANCE RESEARCH CENTER (UHMRRC) . . . . . . . . . . . .45 PUBLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46 GRANTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52

ALOHA FROM THE CHAIR I would like to take this opportunity to present the annual 2022-2023 UH Department of Medicine report. May 11, 2023 marked the end of the federal Public Health Emergency for COVID-19, but we continue to emerge from the pandemic without complete knowledge of the long-term sequelae from infection and dealing with the acute healthcare provider shortages.

Nevertheless, the past academic year was marked by the following successes for the Department: 53 active or new research grants for the Department's faculty totaling over $4,000,000 and 71 peer-reviewed research publications.

11 promotions including 3 full professors in the M-series We honored the members of our clinical faculty who have unselfishly and steadfastly taught medical students and residents for over 10, 15, 20 and 30 years. (Without our 345+ clinical faculty, we would have neither an accredited medical school, nor an internal medicine residency program.)

In the spring of 2023, we submitted an application for a new UH Primary Care Internal Medicine Residency Program – the first application of a full residency program sponsored by UH in over 30 years! The goal is to fill the ranks of sorely needed primary care internists throughout the State of Hawaii.

We awarded the first recipient, Reid Ikeda MD, the inaugural Dr. Elizabeth Tam Award, which perpetually honors Dr. Tam’s core values during her tenure as the Department of Medicine Chair.

In response to the physician shortage especially on the Neighbor Islands, we implemented a recruitment strategy for primary care on the Neighbor Islands and hired two Department of Medicine faculty, Dr. Sydney Tatsuno and Dr. Dane Kurohara, who reside on Hawaii Island and Maui, respectively. These neighbor island physicians are instrumental in leading and building undergraduate and graduate medical education for the Department.

We celebrated the retirement of Dr. Roland Ng, who for decades played a key role in medical resident and student education at Kuakini Medical Center.

There is much work to be done in Academic Year 2023-2024 and I appreciate all of the important contributions and sacrifices that the Department of Medicine faculty and team offer to be able to grow and celebrate successes. I wish you another and even more successful year!

Sincerely, Scott Kuwada, MD Chair and Professor of Medicine 1

MAUI NŌ KA ‘OI

DEPARTMENT LEADERSHIP

Scott K. Kuwada, MD AGAF, FACP

Professor and Interim Chair

Dominic Chow, MD, PhD, MPH Professor and Associate Chair of Research

Todd B. Seto, MD, MPH Associate Professor and Vice Chair

Christie Izutsu, MD

Assistant Professor and Associate Chair of Undergraduate Medical Education

Miki Kiyokawa, MD

Assistant Professor and Associate Chair of Clinical Faculty

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OUR PAID AND VOLUNTEER FACULTY GENERAL MEDICINE - HOSPITAL MEDICINE

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Gary Ahn, MD

Henry Lew, MD

Stephanie Pyskir, MD

Kristie Akamine, MD

Kuo-Chiang Lian, MD

Malia Ramirez, MD

Henry Cacanindin, MD

Yuree Lin, MD

Young Soo Rho, MD

Bo Yin Chang, MD

Sandra Loo, MD

Makiko Sawada, MD

Christina Chong, MD

Van Luu, MD

Hannah Schmitz, MD

Wayne Chun, MD

George Macris, MD

David Spinks, MD

Irina Crook, MD

Thomas Maglinao, MD

Alison Tamiya, MD

Serena Del Mundo, MD

Monica Mau, MD

Aileen Tamura, MD

Gautam Deshpande, MD

Larissa Medina, MD

Raquel Tello, MD

Mai-Linh Frascarelli, MD

Francisco Mercado Jr., MD

Richa Varshney, MD

Michael Furlong, MD

Fatema Merchant, MD

Alena Velasco-Hughes, MD

Ashish Goyal, MD

Christopher Middleman, MD

Christine Wang, MD

Joanna Griffin-Boyce, MD

Keisuke Miyamoto, MD

Travis Watai, MD

Julianne Griswold, DO

Chi-Cheng Morehead-Yang, MD

Jordan Winston, MD

Catherine Ho, MD

Nani Morgan, MD

Stephanie Yoshimura, MD

Ryan Honda, MD

Kelly Nakamura, MD

Satomi Zukeran, MD

Daniel Hong, MD

Toni Narimasu, MD

Dorothy Iwanski, DO

Paul Nho, MD

Susannah Jensen, MD

Jennifer Nishioka, MD

Diana Kim, MD

Masayuki Nogi, MD

Miki Kiyokawa, MD

Neil Onizuka, MD

Christopher Kwock, MD

Ronald Pangilinan, MD

Jatinder Lachar, MD

Robert Pangilinan, MD

Ynhu Le, MD

Dawn Peterson, DO

Qi Jie Nicholas Leo, MD

Jason Pirga, MD

GENERAL MEDICINE - PRIMARY CARE Rachel Ackerman, MD

Janice Fong, MD

Dane Kurohara, MD

Cameron Ryan, MD

Julie Andrada, MD

Victoria Fox-Behrle, MD

Todd Kuwaye, MD

Daniel Saltman, MD

Timothy Au, MD

Daniel Gallares, MD

Sharon Lawler, MD

Florian Sattelmacher, MD

Lisa Barville, MD

Mina Ganapathy, MD

Nicole Leong, MD

Kenneth Schwab, MD

Steven Brauer, MD

Rebecca Gelber, MD

Sandy Liang, MD

Scott Serrano, MD

Bryan Brown, MD

Martin Guerrero, MD

Mark Lum, MD

Robin Seto, MD

Francis Buto, MD

Amanda Haley, MD

Anthony Magliulo, MD

Dorothy Shigaki, MD

Vanessa Cabe, MD

Scott Himeda, MD

Robin Matsukawa, MD

Craig Shikuma, MD

Lisa Camara, MD

Deborah Hirose-Ridao, MD

Kenneth Minami, MD

Royce Shimamoto, MD

Boyuan Cao, MD

Aaron Hoo, MD

John Misailidis, MD

Helen Sim, MD

Dee-Ann Carpenter, MD

Gregory Howick, MD

Ashley Morisako, MD

Anthony Siu, MD

Li-Hsieh Chen, MD

Jason Hughes, DO

Aaron Morita, MD

Matthew Slavin, MD

Hausen Cheong, MD

Birendra Huja, MD

Ronald Morton, MD

Lisa Sodetani, MD

Baron Ching, MD

Noriko Hunter, MD

Mitchell Motooka, MD

John Taitano, MD

Keila Ching, MD

Malissa Iida-Takashima, MD

Stuart Nakamoto, MD

Brandon Takase, MD

Chelsea Ching-Endow, MD

Elliot Kalauawa, MD

Travis Nakamura, MD

Marissa Takase, MD

Chisoo Choi, MD

Florence Kan, MD

Ashlee Nekoba, MD

Laurie Tam, MD

Dominic Chow, MD, PhD

Janet Kao, MD

Stephen Oishi, MD

Dawn Taniguchi, MD

Bradley Chun, MD

Naomi Karlen, MD

Reese Omizo, MD

Eugene Tareshawty, MD

John Chung, MD

Jennifer Katada, MD

Janet Onopa, MD

Sydney Tatsuno, MD

Carrie Colmenares Roys, MD

Misao (George) Kawamura, MD

Vanessa Osedo-Bleecher, MD

Nadine Tenn Salle, MD

Anne Dempsey, MD

Kelly Kawaoka, MD

Abhinetri Pandula, MD

Laura Wong, MD

Stephen Denzer, MD

Kenneth Kepler, MD

Stefanie Park, MD

Lydia Wong Takazawa, MD

Emily Diep, MD

Elizabeth Kiefer, MD

Elizabeth Quinn, MD

James Yess, MD

Maegan Doi, MD

Claudine Kimura, MD

Glenn Rediger, MD

Nathaniel Enriquez, MD

Katherine Kingsley, MD

Tara Reed, MD

Clayton Everline, MD

Elizabeth Koehler, MD

Aldrich Alden Ricalde, MD

Yue Fang, MD

Jeremy Kort, DO

Macario Rivera, Jr., MD

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ALLERGY & IMMUNOLOGY

DERMATOLOGY

Matthew Lau, MD John McDonnell, MD Megan Motosue, MD Bruce Nelson, MD Marina Ostroukhova, MD

John Boyer, MD Kevin Dawson, MD Wayne Fujita, MD Miki Garcia, MD Roman Glamb, MD Sarah Grekin, MD Frederick Harada, MD Philip Hellreich, MD Douglas Johnson, MD

CARDIOLOGY Omar Abdul Ghani, MD Michael Aldridge, MD Steven Azuma, MD Ramy Badawi, MD Denny Bales, MD Dipanjan Banerjee, MD Giselle Baquero Caranama, MD William Boisvert, PhD Michael Brodsky, MD Michael Chan, MD Sanah Christopher, MD John Cogan, MD Samuel Dacanay, MD Osamu Fukuyama, MD Paul Ho, MD Randolph Hutter, MD Gautham Kanagaraj, MD John Kao, MD Kris Kawamoto, MD Anne Kemble Luo, MD Zia Khan, MD

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Alan Kuo, MD Helaine Kwong, MD Carol Lai, MD Luke Lam, MD Rachel Lee, MD Joana Magno, MD Jesus Pino Moreno, MD Benjamin Plank, MD Kahealani Rivera, MD Kevin Salire, MD Katie Schoenman, MD Michelle Seidel Tallquist, PhD Todd Seto, MD Neal Shikuma, MD Ralph Shohet, MD David Singh, MD Andrew So, MD Michael Tanoue, MD Margo Vassar, MD Mahdi Veillet-Chowdhury, MD Sekon Won, MD

Dylan Lee, MD Christopher-Allan Lum, MD Joseph McKinlay, MD Westley Mori, MD Carla Nip-Sakamoto, MD Ethan Routt, MD Greg Sakamoto, MD Ryan Sato, MD

ENDOCRINOLOGY Michael Bornemann, MD Isabel Casimiro, MD, PhD Judith Dickert, MD Sophia Hazel, DO Paul Kim, MD Jennifer Loh, MD

Steven Lum, MD John Melish, MD Alan Parsa, MD Cindy Pau, MD Kelsey Shikuma Lee, MD Lisa Wong, MD

GASTROENTEROLOGY Christopher Aoki, MD Daniel Chan, MD Larissa Fujii-Lau, MD Daryl Fujiwara, MD John Garvie, MD James Grobe, MD Shilpa Jain, MD Ankur Jain, MD Robert Jao, MD Scott Kuwada, MD Herbert Lim, MD Kristi Lopez, MD Joseph Manlolo, MD

Traci Murakami, MD Fernando Ona, MD Mel Ona, MD Gavin Park, MD Anahita Rezaie, MD Neal Shimoda, MD Jennifer Tamai, MD Chuong (Jason) Tran , MD Naoky Tsai, MD Matthew Tsushima, MD Russell Yang, MD, PhD Brandon Yim, MD

HEMATOLOGY/ ONCOLOGY

NEUROLOGY

Jared Acoba, MD Jeffrey Berenberg, MD Jami Fukui, MD Jon Fukumoto, MD Brian Issell, MD Jodi Kagihara, MD Kaye Kawahara, MD William Loui, MD

Stacy Brown, MD Michiko Bruno, MD Monique Canonico, MD Vivian Chin, MD Karen DaSilva, MD Todd Devere, MD Alexandra Galati, MD Fay Gao, MD Brandon Hirota, MD David Kaminskas, MD Matthew Koenig, MD Christopher Kurahashi, MD Kore Liow, MD Jeffrey Liu, MD Michael Lui, MD J Douglas Miles, MD, PhD Karen Morgenshtern Yacoby, MD

Gordon Nakano, MD Ryon Nakasone, MD Elizabeth Nakasone, MD, PhD Jessica Rhee, MD Kenneth Sumida, MD David Tamura, MD Naoto Ueno, MD, PhD Nicolas Villanueva, MD

INFECTIOUS DISEASE Erlaine Bello, MD Joel Brown, MD Sharon Chi, MD Heath Chung, MD Tarquin Collis, MD Larry Day, MD Jonathan Dworkin, MD Louie Gangcuangco, MD John Raymond Go, MD Heidi Hillesland, MD

Eric Kajioka, MD Sarah Kemble Verhoef, MD Joseph Koo, MD Doanh Lu, MD Francis Pien, MD Brian Pien, MD Cecilia Shikuma, MD Benjamin Thomas, MD John Vaz, MD Royden Young, MD

NEPHROLOGY Rossini Botev, MD Shiuh-Feng Sherwin Cheng, MD Troy DeNunzio, MD Chuong (Jason) Dinh, MD Rick Hayashi, MD James Ireland, MD Christie Izutsu, MD Brian Lee, MD

Christopher Middleman, MD David Na'ai, MD Roland Ng, MD Kunal Parekh, MD Carmen Stanko, MD Jared Sugihara, MD Thomas Tasaki, MD Kalani Yamamoto, MD

Kazuma Nakagawa, MD Beau Nakamoto, MD Stuart Pang, MD Viren Patel, MD Katherine Podraza, MD Ray Romero, MD George Weber Ross, MD Peter Rossi, MD Michael Russo, MD Rony Salem, MD Terry Shimamoto, MD Alan Stein, MD Jason Viereck, MD, PhD Melvin Wong, MD Victoria Wong, MD Melvin Yee, MD

PAIN & PALLIATIVE CARE Ilan Bernstein, MD Michael Duick, MD Merle Mirua Akamine, MD Nicholas Muraoka, MD Coswin Saito, MD Maria Termulo, MD PC

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PULMONARY/ CRITICAL CARE Benjamin Berg, MD Reid Ikeda, MD Ehab Daoud, MD Gehan Devendra, MD T. Scott Gallacher, MD Emilio Ganitano, MD John Kot, MD Brent Matsuda, MD Alvin Furuike, MD Julius Pham, MD Bruce Soll, MD Christopher Fiack, MD Donald Helman, MD Artur Krupa, MD Janet Myers, MD Jonathan Paladino, MD Phillip Verhoef, MD Danilo Ablan, MD Nishal Brahmbhatt, MD Anjuli Brighton, MD Christian Castaneda, MD Hangyul Chung-Esaki, MD Graham Cormack, MD Eric Crawley, MD Samuel Evans, MD Russell Gilbert, MD Stephanie Guo, MD Karin Halvorson, MD

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REHABILITATION MEDICINE

Malcolm Haruno, MD

Cedric Akau, MD

Hao Chih Ho, MD

Merle Miura-Akamine, MD

Ryotaro Kato, MD

Nicholas Muraoka, DO

David Kim, MD

Coswin Saito, MD

Karthik Kode, MD

Jordan Wang, MD

Sailaja Kolli, MD Sreenandh Krishnagopalan, MD Gary Kuniyoshi, MD Jordan Lee, MD Peter Lee, MD Anthony Migura, MD Angelina Narashima, MD Hiro Sung, MD

RHEUMATOLOGY Mary Ann Antonelli, MD

Jefferson Roberts, MD

Ken Arakawa, MD

Alberto Santos Ocampo, MD

David Finger, MD

Mari Shiraishi, MD

Sadao Jinno, MD

Kristine Uramoto, MD

James McKoy, MD

Kelly Wachi, MD

Kahoko Taki, MD Brent Tatsuno, MD Bradley Tokeshi, MD Yash Trivedi, MD Makoto Uchiyama, MD Mark Valdez, MD Timothy Vossler, MD Thomas Wong, MD James Yang, MD Brandon Yim, MD Roger Yim, MD

RESEARCH Yuka Eto, MD

Scott Souza, PharmD

Toshihiro Hatakeyama, MD, PhD

Victor “Andy” Stenger, PhD

Christina Higa, PhD

Wesley Sumida, PharmD

Eun-Ran Kim, PhD

Toshiko Tomisawa, PhD

Jinseung Kim, PhD

Machiko Yagi, PhD

Juok Park, PhD

Hiroshi Yonekura, PhD

Christoph Rettenmeier, PhD

Zidan Yu, PhD

Eri Sato, PhD

Guangxiang Zhang, PhD

2022-2023

FACULTY HIGHLIGHTS JARED ACOBA, MD

ASSOCIATE PROFESSOR ONCOLOGY Was promoted to Associate Professor. Continued the phase II study of TSR-022 in combination with TSR-042 for the treatment of advanced hepatocellular carcinoma (PI). Authored four peer-reviewed articles, including "Racial Disparities in Patient-Provider Communication During Telehealth Visits Versus Face-to-face Visits Among Asian and Native Hawaiian and Other Pacific Islander Patients With Cancer: Cross-sectional Analysis" which was published in JMIR Cancer and "Pancreatic cancer among Pacific Islanders: a comprehensive analysis of an understudied racial group" published in Ethnicity & Health.

DIPANJAN BANERJEE, MD, MS ASSOCIATE PROFESSOR CARDIOLOGY DIVISION CHIEF

Was promoted to Associate Professor. Received an Excellence in Cardiology teaching award for the fourth consecutive year from the UH Internal Medicine Residency Program.

ERLAINE BELLO, MD

ASSOCIATE PROFESSOR INFECTIOUS DISEASE DIVISION CHIEF Was appointed Interim Program Director, Primary Care Track, UHIMRP and continued to lead The Queen's Health Systems Infection Prevention and Control Department's COVID-19 activities.

BENJAMIN BERG, MD PROFESSOR PULMONARY/ SIM TIKI

Authored the book chapter "Remote Faculty Development Programs for Simulation Educators-Tips to Overcome Barriers" in Advances in Smart Healthcare Paradigms and Applications. Composed five peerreviewed articles including "Simulation Past, Present, and Future" published in Clin and Exp Emerg Med. Received an academic award from the Fellow Society of Simulation in Healthcare Academy. As an invited speaker, presented at 10 international workshops and conferences, including the Collaborative Co-Learning Simulation workshops (COCOSIM) and the Korean Society for Clinical Procedures and Education.

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WILLIAM BOISVERT, PhD PROFESSOR CARDIOLOGY

Continued his research "NIH Monocytes and macrophages in HIV cardiovascular risk" (PI) and "AHA Lipid metabolism in the endothelium" (PI). Was part of the teams to author "Alterations in Renin–Angiotensin System (RAS) Peptide Levels in Patients with HIV" published in Metabolites and "Characterization of circulating fibrocytes in people living with HIV on stable antiretroviral therapy" published in ImmunoHorizons. As an invited speaker, presented his research at the Joint Meetings of Coronary Revascularization (JCR) and the Cardiac Regeneration and Vascular Biology Conference.

STACY BROWN, MD ASSISTANT PROFESSOR NEUROLOGY

Continued her research “Genetic Determinants of Cerebrovascular Disease and Brain Resilience in Multi-Ancestral Hawaiian Populations" and “Perceptions of Genomic Medicine and Technology among Native Hawaiian Patients Enrolled in a Longitudinal Healthcare Engagement Program” (PI). Authored "A genome-wide association study of frailty identifies significant genetic correlation with neuropsychiatric, cardiovascular, and inflammation pathways" published in Geroscience. Presented her research at the National IDeA Symposium of Biomedical Research Excellence and the Society of Neurointerventional Surgery.

CHRISTINA CHONG, MD ASSISTANT PROFESSOR HOSPITAL MEDICINE

Received Faculty Award for Excellence in Teaching from the UH Internal Medicine Residency Program for her second consecutive year. Collaborated with residents in authoring "Are Patients with HHV-8 Associated Castleman Disease Successfully Treated with Rituximab at Risk of Subsequently Developing HHV-8 Negative (Idiopathic) Castleman Disease?" and "Eosinophilic Myocarditis Presenting as Cardiac Tamponade: A Diagnostic Challenge", both published in the European Journal of Case Reports in Internal Medicine.

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DOMINIC CHOW, MD, PhD, MPH PROFESSOR PRIMARY CARE

Was named Educator of the Year by the Hawaii Chapter of the American College of Physicians. Continued his research on the "Role of Monocyte/Macrophage in HIV-related Cardiovascular Risk" (PI) and "Unpacking the Mechanisms of Disparities for HIV-Related Hypertension in African American and Asian Pacific American Men who have Sex with Men (MSM) Study", along with five additional grants. Authored 11 peer-reviewed articles, including "Increased Transmigration of Intermediate Monocytes Associated with Atherosclerotic Burden in People with HIV on Antiretroviral Therapy" published in AIDS. Gave 6 presentations at national conferences, such as the 2022 CHEST Annual Meeting and the 2022 and 2023 Conference on Retroviruses and Opportunistic Infections (CROI).

EHAB DAOUD, MD ASSOCIATE PROFESSOR CRITICAL CARE

Was promoted to Associate Professor. Received Faculty of the Year Award from JABSOM and Physician "Respiratory Champion" Award from the Hawaii Society of Respiratory Care for his second year.

Continued to serve as the Founder and President of the Society of Mechanical Ventilation and Editor in Chief of the Journal of Mechanical Ventilation.

GEHAN DEVENDRA, MD ASSISTANT PROFESSOR

PULMONARY/ CRITICAL CARE DIVISION CHIEF Was awarded funding for his research "Factors Responsible for the Development of Pulmonary Post-Acute Sequelae of SARS-CoV-2 Infection (PPASC) in Hawaii" (PI). Authored three peer-reviewed articles, including "Phenotypic alteration of low-density granulocytes in people with pulmonary post-acute sequalae of SARS-CoV-2 infection" published in Front Immunol. Presented at 10 speaking engagements held at conferences such as the 2023 American Thoracic Society International Conference, Conference on Retroviruses and Opportunistic Infections (CROI), and CHEST Nashville 2022.

LOUIE GANGCUANGCO, MD, MSc ASSISTANT PROFESSOR INFECTIOUS DISEASE

Joined the Department in July 2022. Authored three peer-reviewed articles, including "The State of the HIV Epidemic in the Philippines: Progress and Challenges in 2023" in Tropical Medicine and Infectious Disease and "Factors associated with colorectal cancer screening adherence and the impact of COVID-19 on screening patterns in Connecticut, USA" in Internal Emergency Medicine. He is the new Principal Investigator of the Pacific AIDS Education and Training Center for the Hawaii and US-affiliated Pacific Islands, leading HIV education in the Pacific.

REID IKEDA, MD

ASSOCIATE PROFESSOR PULMONARY/ CRITICAL CARE Continued in his role as Program Director of the UH Internal Medicine Residency Program. Continued in his role as the American Lung Association of Hawaii and Leahi Fund Endowed Chair in Respiratory Health. Continued research projects focusing on "The Role of Biomarkers in Predicting the Successful Application of High-Flow Nasal Cannula (HFNC) in COVID-19 Pneumonia." Received the Elizabeth "Liz" Keali'ikua'aina Tam, MD Memorial Award.

ZIA KHAN, MD, MPH

ASSISTANT PROFESSOR CARDIOLOGY DIVISION CHIEF Was appointed Cardiology Division Chief. Served as Chief of Queen’s Heart Institute and Medical Director of Enterprise Access for Queen’s Health Systems. Served as Board President of Hawaii Division of American Heart Association. Po’okela Award for Leader of the Year for QHS. Co-developed RIDGETRail Medical Education Certification Pathway Pilot for Cardiology.

MIKI KIYOKAWA, MD ASSISTANT PROFESSOR

HOSPITAL MEDICINE & ADDICTION MEDICINE Was appointed Associate Chair of Clinical Faculty for the Department.

Received two Outstanding Teaching Awards for General Psychiatry and Addiction Medicine, presented by the UH Department of Psychiatry. Continued her research "Facilitators and barriers to implementation of a pilot methamphetamine treatment program at a Level I trauma center" (Co-I). As an invited speaker, presented at the American College of Academic Addiction Medicine Weekly Didactic Sessions and the Hawai'i Department of Health Alcohol and Drug Abuse Division Webinar.

MATTHEW KOENIG, MD ASSOCIATE PROFESSOR NEUROLOGY Continued his research “Kinā’ōle: Expanding Telestroke Coverage to the Prehospital Setting in Hawaii’s Rural Communities HRSA Telemedicine Network Grant Program (TNGP)” (PI).

DANE KUROHARA, MD ASSISTANT PROFESSOR PRIMARY CARE

Was appointed as Assistant Professor, our first departmental-funded faculty member on Maui island, a key step towards expanding our education programs in neighbor islands.

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SCOTT KUWADA, MD

INTERIM CHAIR AND PROFESSOR GASTROENTEROLOGY DIVISION CHIEF Received three new grants for the academic year, including the new U54 award for increasing colorectal cancer screening in Pacific Islanders in Hawaii and Guam.

KUO-CHIANG LIAN, MD

ASSOCIATE PROFESSOR NEUROLOGY DIVISION CHIEF

Authored "Forkhead box O3 longevity genotype may attenuate the impact of hypertension on risk of intracerebral haemorrhage" in J Hypertens. Was part of the team who authored "FOXO3, a Resilience Gene: Impact on Lifespan, Healthspan, and Deathspan", published in J Gerontol A Biol Sci Med Sci. Presented his research at the Congress of International Society of Hypertension and the Alzheimer's Association International Conference (AAIC).

KELLY NAKAMURA, MD

ASSISTANT PROFESSOR HOSPITAL MEDICINE

ASSISTANT PROFESSOR INTERNAL MEDICINE

Received his third award for Excellence in Teaching from the UH Internal Medicine Residency Program.

Was appointed Assistant Professor and Medical Student Site Coordinator for Queen’s Medical Center.

J. DOUGLAS MILES, MD, PhD ASSISTANT PROFESSOR NEUROLOGY

Was awarded the grant "Streamlining the Generation of Neurology Exam Animations for Teaching and Assessment" (PI). Presented at 9 speaking engagements such as the International Association of Medical Science Educators (IAMSE) 2023 Annual Conference and the 3rd International Congress of Health Education and Research & AoME Annual Academic Meeting. As an invited speaker, presented “Why Do I Have to Repeat That? (Or, What the Heck is That Doctor Thinking?)” at the 2023 American Association of Electrodiagnostic Technologists (AAET) Annual Conference.

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KAZUMA NAKAGAWA, MD

RYON NAKASONE, MD ASSISTANT PROFESSOR HEMATOLOGY & ONCOLOGY

Co-authored "Disaggregating Data on Pacific Islander Gastric Cancer Patients Reveals Survival Disparity" published in J Gastrointest Cancer.

CHRISTOPH RETTENMEIER, PhD ASSISTANT RESEARCHER

UH MAGNETIC RESONANCE RESEARCH CENTER Continued his research "Cell-to-cell death along myofibers in ischemic heart disease" and "Longitudinal Study of Early NAFLD Progression and the Gut Microbiome in Asian Americans, Native Hawaiians and Whites" along with 3 additional grants. Was part of the teams to present at conferences such as the ISMRM & ISMRT Annual Meeting & Exhibition and Anatomy Connected.

MICHELLE TALLQUIST, PhD PROFESSOR CARDIOLOGY

Continued her research "Role of Fibroblasts in Cardiovascular Inflammation" (PI) and "Role of Lipofibroblast in Alveolar Development" (PI) along with 3 additional grants. Presented "Functional Consequences of Fibroblast Loss in Tissue Homeostasis and Disease" as invited guest at conferences held by the American Heart Association's (AHA) Basic Cardiovascular Sciences (BCVS) and International Service for Heart Research (ISHR).

TODD SETO, MD, MPH VICE CHAIR & PROFESSOR CARDIOLOGY

Continued working on seven extramural grants including "Hawaii Clinical Research Network for Health Equity" (Co-PI) and "Hawaii Interdisciplinary Mentored Career Development in HIV CoMorbidities" (Co-PI). Authored "Differences in COVID-19 Hospitalizations by Self-Reported Race and Ethnicity in a Hospital in Honolulu, Hawaii" in Preventing Chronic Disease along with 4 other publications. Presented "Performance of Society of Thoracic Surgeons and EuroSCORE II pre-surgical mortality risk score for cardiac surgery in a large majority-minority population" at the European Society of Cardiology Congress.

ROYCE SHIMAMOTO, MD ASSISTANT PROFESSOR HOSPITAL MEDICINE

Received his third Kuakini Teaching Award, in recognition of his contribution to the UH Internal Medicine Residency Program. Also received the Kaiser-Permanente Excellence in Clinical Teaching award, which celebrates exceptional teaching in the third and fourth year clinical curriculum.

RALPH SHOHET, MD PROFESSOR CARDIOLOGY Continued work on ultrasound-targeted microbubble-based gene delivery, publishing a paper that showed this method could deliver CRISPR tools effectively to the liver. Initiated a project to explore the sex-specific cardiac damage of methamphetamine, and continued work on the epigenetics and metabolic consequences of cardiac hypoxia. Supervised the tenth year of the cardiovascular training grant and submitted a successful renewal with Dr. Tallquist as the new PI.

V. ANDREW STENGER, PhD PROFESSOR

UH MAGNETIC RESONANCE RESEARCH CENTER Continued his research "Radial Echo Volumar Imaging Grant" (PI), "Integrative Center for Precision Nutrition and Human Health", and "Effects of Intermittent Energy Restriction on Intra-Abdominal Fat and the Gut Microbiome: A Randomized Trial". Was part of the teams to present at conferences such as the Proceedings of the ISMRM & ISMRT Annual Meeting & Exhibition and the International Conference on Systems Engineering.

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KENNETH SUMIDA, MD ASSOCIATE PROFESSOR ONCOLOGY Continued in his role as Director of Medical Education at Kuakini Medical Center and Adjunct Assistant Professor and Core Clinical faculty at the University of Hawai’i Cancer Center.

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SYDNEY TATSUNO, MD ASSISTANT PROFESSOR PRIMARY CARE Was appointed as Assistant Professor, our first departmental-funded faculty member on Hawai’i island, a key step towards expanding our education programs in neighbor islands.

TRAVIS WATAI, MD

JAMES YESS, MD

ASSISTANT PROFESSOR HOSPITAL MEDICINE

ASSISTANT PROFESSOR PRIMARY CARE

Was appointed Associate Program Director of the UH Internal Medicine Residency Program. Presented "Answers Lie in the Complete Blood Count: A case of Eosinophilic Granulomatosis with Polyangiitis presenting with Acute ST-wave Elevation Myocardial Infarction" at the 2022 CHEST Annual Meeting.

Elected Chair of the Primary Care Advocacy Committee American College of Physicians Hawaii Division. Received Po’okela Award for Kilolani Native Hawaiian Care Team from the Queen's Health System.

Was awarded the grants "Ola Hawaii Post Covid Pulmonary Long Covid Study" and "Perceptions of Genomic Medicine and Technology among Native Hawaiian Patient Enrolled in a Longitudinal Healthcare Engagement".

DIVISION HIGHLIGHTS CARDIOLOGY DIVISION OVERVIEW

The Cardiology Division is comprised of faculty from a comprehensive array of subspecialties, including general cardiology, interventional cardiology, electrophysiology, advanced cardiovascular imaging, advanced heart failure, and cardiovascular basic science and outcomes research. While we remain committed to enhancing and improving our Fellowship Program in Cardiovascular Diseases, we additionally focused on increasing our support of undergraduate medical education at JABSOM this year, as well as supporting faculty development to further promote a culture of education. Specific activities by the Division include:

UNDERGRADUATE AND GRADUATE MEDICAL EDUCATION Initiating formal medical student mentorships with cardiology faculty.

Developing subspecialty rotations for medical students, particularly in Advanced Heart Failure and Electrophysiology.

Formal didactics for the medical students, including ECG interpretation and physical exam teaching.

Mentorship for Project HEART, a medical student group designed to promote CPR in schools.

Precepting for blood pressure screening in Chinatown by medical students.

Developing a comprehensive Cardiac CT/MR educational curriculum for the fellows.

Offering the MS4 Cardiology elective (MED 545-C).

FACULTY INITIATIVES Drs. Seto and Banerjee were promoted to Full Professor.

Dedicated monthly Cardiovascular Grand Rounds were started this year.

Hawai'i Cardiovascular Symposium, led by Dr. David Singh.

Participation in planning of ACHD CATCH (Caring for Adults and Teens with Congenital Heart Disease) Conference by Dr. Anne Kemble.

Initiation of the RIDGETrail Medical Education Certification Pathway for cardiologists on the inpatient teaching service.

Faculty serve as leaders local community organizations, including Dr. Vassar as Hawai'i American Academy of Cardiology President and Dr. Khan as Hawaii American Heart Association President.

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GASTROENTEROLOGY NEW FACULTY

Dr. Chuong Tran, Assistant Clinical Professor of Medicine, QUMG Liver Center and Transplant Center, graduated from JABSOM, completed residency and GI fellowship at Loma Linda, and completed transplant hepatology fellowship training at UCSF.

RESEARCH

Dr. Larissa Fujii-Lau, Assistant Clinical Professor was the lead- or co-author on 10 publications providing new guidelines for the American Society of Gastrointestinal Endoscopy.

Dr. Chuong Tran, Assistant Clinical Professor of Medicine, QUMG Liver Center and Transplant Center, was named the PI for a new federal grant (Hawaii Clinical Research Network for Health Equity [HICRN-HE] UG3MD018358) study on fatty liver disease (Main PI’s: Dr. Cecilia Shikuma, Dr. Todd Seto and Dr. Venkataraman Balaraman; mentor: Scott Kuwada, MD).

Dr. Scott Kuwada, Interim Chair and Professor of Medicine, Chief of Division of Gastroenterology, UH Cancer Center Seed Grant - Title: Meeting the looming epidemic of hepatocellular carcinoma in Hawaii. The aim of this grant is to recruit patients with metabolic disease associated steatohepatitis, which is overrepresented in Hawaii, with advanced fibrosis for a dietary intervention trial. He was the senior author and co-author on two papers: Mansour MM, Obeidat AE, Darweesh M, Mahfouz R, Kuwada S, Pyrsopoulos NT. The Impact of Cirrhosis on Outcomes of Patients Admitted With Diabetic Ketoacidosis: A Nationwide Study. Cureus. 2022 Jun 12;14(6):e25870. Lee Anson Y, Kuwada SK. Use of an overthe-scope clip in managing adult anastomotic ulcer bleeding. J Surg Case Rep. 2023 Jun; 2023(6).

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HOSPITAL MEDICINE VISION STATEMENT

“As the leading Hospitalist Program in the Pacific Region, we foster a collaborative, supportive philosophy and value the strengths and wellbeing of each individual team member. We champion compassionate, high quality care, elevating patient experience and access. We are dedicated to life long learning, education and innovation.”

- 4/20/2023 Hospitalist Leadership Team Retreat

HOSPITALIST ACADEMIC PROGRAM QUMG Hospitalists serve as the primary teaching attendings for learners on the Internal Medicine Inpatient Service at: Manamana UHIMRP and UHPC residents JABSOM 3rd/4th year medical students TAMC residents (elective), interns (this upcoming year) Psychiatry interns Teaching Structure/Size 4 Hospitalist Teaching Teams per day caring for ~50-55 Manamana inpatients (15% of total census) 11 Dedicated Academic Hospitalists Many more hospitalists hold clinical faculty appointments and rotate periodically through teaching

HIGHLIGHTS UHIMRP graduates pursue Primary Care (25%), Hospitalist Medicine (25%), and Fellowship (50%) American Board of Internal Medicine board pass rate rolling 3 year average from 2019-2021 was 94%. During COVID, 2020-2022, it was 89% (national average 87%). >50% of our residents published or had an abstract accepted for presentation at a conference in the past academic year 88 UHIMRP graduates in the past 10 years are practicing in HI 14 are currently hospitalists with QUMG with 6 more joining this year **36 of 82 (44%) Manamana Hospitalists are JABSOM and/or UHIMRP graduates** 16

5 HOSPITALISTS WON EXCELLENCE IN TEACHING AWARDS Dr. Sandra Loo Dr. Kuo Lian Dr. Christina Chong Dr. Alena Velasco-Hughes Dr. Hannah Schmitz

PUBLICATIONS/POSTER PRESENTATIONS 5 publications 5 poster presentations

NATIONAL CONFERENCES 4 Hospitalists served as Point of Care Ultrasound (POCUS) faculty at the joint UCSF-UH CME annual conference, 6/2023 (Royal Hawaiian) and anticipating this upcoming

6 HOSPITALISTS SERVE IN ACADEMIC LEADERSHIP ROLES Dr. Travis Watai Associate Program Director, UHIMRP Dr. Christina Chong Director of Medical Education, QMC/UHIMRP Dr. David Spinks UHIMRP Firm Advisor, UHIMRP Dr. Kuo Lian Chair, Clinical Competency Committee, UHIMRP Dr. Kelly Nakamura MS3 Clerkship Site Director, JABSOM Dr. Dennis Bolger Director of Clinical Skills, JABSOM/Office of Medical Education

STRATEGIES FOR IMPROVEMENT Held 1st annual Hospitalist Faculty Development Retreat (5/2023) with a follow up mini retreat (1/2023) Identified strategic goals for 2023-2024 Academic Year – improving intern documentation and standardizing upper level resident expectations Aligned goals with Hospitalist Quality Projects Increase faculty development through retreats, journal clubs, and teaching opportunities Enhance resident night float academic experience Embed case manager and social worker on 2 teaching teams to improve multi-disciplinary team communication and patient transitions 2023 Hospitalist Quality Projects with Academic focus Standardize upper level resident expectations based on team structure Revise resident progress note and H&P documentation templates Launch Hospitalist Procedural Teaching Service 17

INFECTIOUS DISEASE DIVISION OVERVIEW The Division of Infectious Diseases (ID) activities reflect the wide scope of the specialty and the transitioning COVID-19 Pandemic times. We are largely an unpaid Clinical department with paid faculty funded for research or residency activities. We provide outpatient, acute inpatient, intensive care unit and long term care facility consultations for the diagnosis and management of identified or suspected bacterial, viral, fungal, parasitic and even prion diseases. We are consulted on patients with perplexing fevers, fatigue, weight loss, lab abnormalities and even delusions of infection. We continue to provide COVID-19 care and expertise at all levels. We provide and oversee home and outpatient intravenous antibiotic infusion programs. Some of us provide primary care for HIV-infected individuals. We actively participate in Infection Prevention and Control programs at the hospital and health systems levels as well as Public Health and policy oversight at the state Department of Health level. We serve in leadership roles in hospital-based Antibiotic Stewardship Programs. We work closely with the Microbiology and Molecular Departments of the major clinical laboratories to assess the value of new diagnostic testing and ongoing review of everchanging antibiotic susceptibility patterns. While the majority of us work on Oahu, the Division membership has expanded to Kauai, Maui and Hawaii island. We provide care in all of the health systems including The Queen’s Health System, Hawaii Pacific Health, Kuakini Health System, Castle Adventist Health and Kaiser Permanente.

TEACHING AND MENTORSHIP We offer electives in Infectious Diseases and HIV to JABSOM 4th year med students and UHIMRP residents. ID faculty generously use their respective clinical practice patients and sites to deliver these elective experiences; the majority of ID faculty are in private practices. We serve as faculty mentors for resident research projects and for residents considering and applying for ID fellowship. We give ID Board review and ID topic-based didactic lectures for UHIMRP Scholarly Activities Sessions. ID faculty members also serve as mentors for new ID colleagues entering clinical practice. ID faculty provide program leadership for UHIMRP.

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RESEARCH/PUBLICATIONS The primary area of funded research continues to be in HIV. ID faculty support resident. While Dr Jonathan Dworkin’s book “Plague Doctors” (which recounts the early Pandemic roles of many division members) was technically published in 2021, it became more widely available in the 2022. ID faculty also support UHIMRP research projects.

COMMUNITY SERVICE We serve on multiple hospital and health system including but not limited to Infection Control, Medication/Pharmacy, Department of Medicine, ICU committees. We provide input into and in some cases write policies and guidelines that relate to infectious diseases and infection control. We serve on JABSOM committees and community Boards.

NEUROLOGY DIVISION OVERVIEW

The Neurology Division is comprised of general neurologists and subspecialized neurologists with fellowship training in clinical neurophysiology, epilepsy, headache medicine, movement disorders, neuroimmunology, neurocritical care, neuromuscular medicine, sleep medicine and vascular neurology. All of the division members participate in the medical student and/or resident teaching programs; and some actively participate in clinical research.

Noteworthy accomplishments including collectively, through the Hawaii Stroke Coalition, with partnership of all the major hospitals in Hawaii, the quality and performance outcome for acute stroke treatment was shown to be significantly better than the U.S. mainland stroke centers.

TEACHING

As clinician-educators for the JABSOM medical students, residents and fellows, it is our obligation to inspire the students and trainees to become the future leaders of the field. Many of the division members participate in the Longitudinal Clinical Mentor program for the first and second-year medical students, as well as second-year medical students’ Clinical Skills Program during their Locomotor, Neurological, and Behavior System, 4th year inpatient and outpatient neurology elective, as well as Internal Medicine residents’ elective and selective rotations in outpatient and inpatient neurology.

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RESEARCH The Neurology Division’s overall research mission is to address health disparities among Native Hawaiians and other underserved population with various neurological conditions. The Queen’s Neuroscience Research program has 1) a research study funded by the Micheal J. Fox Foundation to assess disparities in care of Parkinson’s disease patients among Asian Americans, Native Hawaiians and Pacific Islanders, 2) NIH-funded multicenter study to assess disparities in blood pressure control and cognitive outcome among Native Hawaiians and Asians patients with intracerebral hemorrhage (REACH-ICH), 3) NIH/COBRE-funded study to investigate genetic determinants of cerebrovascular disease among multi-ancestral Hawaiian population. Hawaii Pacific Neuroscience sponsors multiple medical students to participate in research through their Summer Research Internship program. Both Queen’s Neuroscience Research and Hawaii Pacific Neuroscience research programs participate in multiple Phase I, II, and III clinical trials for various neurological disorders.

COMMUNITY OUTREACH As clinician-educators for the JABSOM medical students, residents and fellows, it is our obligation to inspire the students and trainees to become the future leaders of the field. Many of the division members participate in the Longitudinal Clinical Mentor program for the first and second-year medical students, as well as second-year medical students’ Clinical Skills Program during their Locomotor, Neurological, and Behavior System, 4th year inpatient and outpatient neurology elective, as well as Internal Medicine residents’ elective and selective rotations in outpatient and inpatient neurology.

NEPHROLOGY DIVISION OVERVIEW

The Division of Nephrology is dedicated to excellence in patient care, education and clinical advancements in the field of nephrology. As providers, we collaborate to manage complex patients across the state with chronic kidney disease and a growing transplant center which serves the entire Pacific basin. As educators, we facilitate the nephrology rotations for students and residents, paving the way for future nephrologists.

Roland Ng Retirement Celebration Community Nephrologists 20

The division consists of 16 board-certified nephrologists in private practice settings who partner with each of the major health care systems in the state. Together, we provide 24-hour coverage for both established and new patients in all high acuity settings, offering consultative services for conditions including acute kidney injury, end-stage renal disease management and transplant.

For the residency program, we offer a clinical rotation involving inpatient and outpatient management of a variety of renal diseases. Residents are supervised on an inpatient consultative service at Kuakini Medical Center and the Queen’s Medical Center. They also participate in hemodialysis & peritoneal dialysis rounds, CKD clinic and transplant clinic. There is also an opportunity to participate in clinical research and develop individualized clinical rotations. Similar offerings exist for fourth-year medical students interested in an in-depth two- or four-week experience in nephrology. Our division also provides didactic education at various conferences including grand rounds for the University and Transplant Center, Queen Emma Clinics, Scholarly Activities Session, MD3 and the surgery residency program.

Collectively, the division has published several papers in JASN and in collaboration with NKF to highlight the kidney health disparities for Native Hawaiians and Pacific Islanders, as well as the overall growing need for greater nephrology resources in the state. Work is ongoing in conjunction with the state’s federally qualified healthcare centers to promote culturally sensitive multidisciplinary care for CKD patients and with the medical school on strategies to address these needs.

PULMONARY/ CRITICAL CARE DIVISION OVERVIEW The Division of Critical Care Medicine spans multiple intensive care units (ICU) throughout Hawaii including staffing via virtual health to the Big Island and Kauai. We have staff that serves the ICUs at Queens Medical Center- Manamana, Queens Medical Center- West, Straub Medical Center, Pali Momi Medical Center, Kuakini Medical Center and Kaiser Monanalua Hospital. We have a total of over 100 ICU beds between our hospitals and have a range of ICU services including medical intensive care, cardiac intensive care, medical and surgical critical intensive care and also extracorporeal membrane oxygenation (ECMO). Over 7000 patients per year are admitted through our hospitals and treat a range of illness including septic shock, acute respiratory failure, pulmonary hypertension, heart failure, post cardiac arrest and post cardiac surgery. We also cannulate about 40 ECMO cases per year. The key staff of the simulation center at JABSOM is included in our faculty. Our physicians are a critical asset in the training of critical care medicine for the University of Hawaii Internal Medicine Residency Program, Tripler Internal Medicine Residency Program, University of Hawaii Family Medicine Residency Program, and the Kaiser Internal Medicine Residency Program.

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MEDICAL STUDENT EDUCATION The John A. Burns School of Medicine (JABSOM)'s MD program is unique in its use of Problem-Based Learning (PBL) and Community-based Medicine. Students are trained in affiliated community hospitals and clinics, which gives them real-world experience from the start. Through PBL, our first and second year students are educated to think critically, to identify and define new information and learning issues by evaluating and researching data, and apply their new knowledge to the problem at hand. Our Departmental faculty hold key leadership and teaching roles in PBL and Longitudinal Clinical Preceptorship (LCP), mentoring students in clinical problem solving and effective communication with patients, their families, and other members of the health team. Third year students are introduced to the breadth and depth of Inpatient and Ambulatory Internal Medicine, the foundation for all clinical specialties. During their required Internal Medicine Clerkship, they receive blankasdf supervised, formative experiences in the evaluation and management of patients, spending 4 weeks in an inpatient setting and a semester in an outpatient setting. Fourth year medical students rotate through required and elective learning opportunities in general medicine and internal medicine subspecialties based on their interests and career goals. Our department alone offers a range of twenty fourth-year courses in both inpatient and outpatient settings, including neighbor islands. As a whole, our medical education program enables learners to achieve JABSOM's graduation objectives and helps assure accreditation of the school by the Liaison Committee on Medical Education while educating current and future healthcare professionals and leaders.

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UNIVERSITY OF HAWAII

INTERNAL MEDICINE RESIDENCY PROGRAM (UHIMRP)

UH Internal Medicine Residency Program White Coat 2023. Deborah Dimaya photo taken on June 29, 2023.

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A MESSAGE FROM THE PROGRAM DIRECTOR I view UHIMRP as an extended family that emphasizes teamwork between our faculty, residents, students, and program staff. We aim to provide exceptional patient care, and to cultivate an optimal learning environment that is characterized by collegiality, shared responsibility, and professionalism.

Hawaii is a special place with rich diversity, and the spirit of Aloha should guide our interactions with patients and colleagues.

Mahalo, Dr. Reid Ikeda UHIMRP Program Director

OUR MISSION

Our MISSION is that residents, faculty and staff of UHIMRP will be dedicated to the service of our community in Hawai‘i and the Pacific through education, research and quality patient care.

OUR VISION

Our VISION is to become an ‘ohana (family) characterized by teamwork and mutual respect in a supportive learning environment. We envision a future in which we are integrated with the community, responsive and adaptive to change, and internationally renowned for excellence in patient care and the quality of our residents, faculty and medical education.

UHIMRP 2022-23 Chief Medical Residents 24

OUR RESIDENTS

*Preliminary Track

**Primary Care Pathway

LEVEL 1

Noppawit Aiumtrakul, MD

Kyle Alimurung, MD

Chinnawat Arayangkool, MD

Nicole Chong, MD**

Titus David, MD

Jonathan Estaris, MD

Osama Hasan, MD

Shuhei Hattori, MD

Julie Hong, MD*

Kelsey Kwong, MD

Aiko Murakami, MD

Steven Namiki, MD

Kevin Edward Nebrejas, MD

Carly Pappo, MD*

Dillon Tacdol, MD

Kensuke Takaoka, MD

Arvin Jeremy Tan, MD

Manasawee Tanariyakul, MD

Maluikeau Tang, MD**

Kristine Vo, MD

Miki Yokokawa, MD

LEVEL 2

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Kevin Benavente, DO

Bolin Chang, MD

Chesta, MD

Kyle Deacon, MD

Bryan Aaron Ganzon, MD

Maan Gozun, MD 1/29/22‐1/28/23

Gavin Ha, MD

Mohammad Khan, MD

Landon Kozai, MD

Jason Kuniyoshi, MD

Joseph Lee, MD

Thiratest Leesutipornchai, MD

Taryn Miyake, MD

Andrew Pham, MD

R. Haris Rizwan, MD

Haruki Sawada, MD

Joshua Taylor, MD**

Witina Techasatian, MD

Brendan Tran, DO**

Chase Warashina, MD

Amanda Wasko, MD

LEVEL 3

Marci Chock, MD 9/22/21 ‐ 8/23/2022

Horyun Choi, MD

Torrey Czech, MD

Joseph Go, MD**

Alison Goo, MD**

Robert Holm‐Kennedy, DO

Ricky Huang, MD

Brysa Kato, MD

Koichi Keitoku, MD

Nobuhiko Kimura, MD

Chengcheng Li, MD 09/28/22‐09/27/23

Daniel Miyamoto, MD

Todd Nagamine, DO

Yoshito Nishimura, MD 09/01/22‐08/31/23

Christina Park, MD

Keith Sablan, MD

Parthav Shah, MD

Bryce Tanaka, MD

Jihun Yeo, DO

Stephanie Yoshimura, MD 12/16/21‐12/15/22

CHIEF MEDICAL RESIDENTS

Nathaniel Enriquez, MD

Florence Kan, MD

ASSOCIATE PROGRAM DIRECTORS

Travis Watai, MD

Erlaine Bello, MD

Gene Yoshikawa, MD

PRIMARY CARE TRACK PROGRAM DIRECTOR

James Yess, MD

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UH Internal Medicine Residency Program Graduation. Taken on June 2, 2023.

AWARDS THE INTERN OF THE YEAR Nicole Chong, MD Arvin Tan, MD Maluikeau Tang, MD

RESIDENT (UPPER) OF THE YEAR Todd Nagamine, MD

EXCELLENCE IN MEDICAL STUDENT TEACHING AWARD Yoshito Nishimura, MD

EXCELLENCE IN ULTRASOUND SIMULATION TRAINING AWARD Kevin Benavente, MD

RYDER ONOPA MOST INSPIRATIONAL RESIDENT OF THE YEAR AWARD Yoshito Nishimura, MD

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EXCELLENCE IN RESEARCH First Year: Jonathan Estaris, MD Second Year: Maan Gozun, MD Witina Techasatian, MD Landon Kozai, MD Third Year: Yoshito Nishimura, MD Parthav Shah, MD

QMC: OUTSTANDING INTERN & UPPER Intern: Nicole Chong, MD Upper: Yoshito Nishimura, MD

KMC: OUTSTANDING INTERN & UPPER Intern: Maluikeau Tang, MD Upper: Koichi Keitoku, MD

QEC: EXCELLENCE IN AMBULATORY MEDICINE First Year: Arvin Tan, MD Second Year: Kevin Benavente, DO Third Year: Todd Nagamine, MD

STRAUB: OUTSTANDING INTERN FOR STRAUB MEDICAL CENTER ICU Kelsey Kwong, MD

GOLDEN CRAB AWARD (SECRET) Yoshito Nishimura, MD

OUTSTANDING TEAM PLAYERS First Year: Steven Namiki, MD Second Year: Haruki Sawada, MD Jason Kuniyoshi, MD Third Year: Chengcheng Li, MD Horyun Choi, MD

RECOGNITIONS: Nicole Chong, MD Manasawee Tanariyakul, MD Kristine Vo, MD Kevin Benavente, DO Bolin Chang, MD Chesta, MD Kyle Deacon, MD Bryan Ganzon, MD Gavin Ha, MD Mohammad Khan, MD Landon Kozai, MD

Haris Rizwan, MD Witina Techasatian, MD Chase Warashina, MD Amanda Wasko, MD Alison Goo, MD Brysa Kato, MD Nobuhiko Kimura, MD Daniel Miyamoto, MD Todd Nagamine, MD Bryce Tanaka, MD Jihun Yeo, MD 28

CARDIOVASCULAR DISEASE (CVD) FELLOWSHIP FELLOWSHIP EDUCATION

New cardiac CT/MRI rotation and curriculum: Lead by Dr. Veillet-Chowdhury.

Developing a new CCU/HF rotation curriculum for the fellows.

Development of cardiology didactic curriculum lead by Dr. Omar Abdul Ghani.

Wellness Curriculum Development lead by Dr. Margo Vassar.

Faculty Participation with the RIDGE trial run by Dr. Bryan Brown for faculty teaching education: Dr. Zia Khan, Dr. Helaine Kwong, Dr. Nath Limpruttidham, Dr. Michael Tanoue, Dr. Alan Kuo, Dr. Jesus Pino-Moreno.

MEDICAL SCHOOL EDUCATION INITIATIVES:

Project CARE: Please see attached document. Lead with Dr. Helaine Kwong.

Medical Student Mentorship Program: We have faculty involved in medical student mentorship: Dr. Omar Abdul Ghani.

Cardiovascular disease fellows volunteered in medical students’ educational activities throughout the year.

COMMUNITY/PHYSICIAN EDUCATIONAL DEVELOPMENTS:

Hawaii Cardiovascular Symposium 6/2023, lead by Dr. David Singh.

Caring for Adults and Teens with Congenital Heart Disease 10/2022: Dr. Anne Kemble-Lou on the planning committee.

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QUMG CVD FELLOWS FIRST YEAR FELLOWS

Rahul Ahuja, DO

Pooja Dhruva, MD Gagandeep Rajpal, MD

Benita Tjoe, MD

SECOND YEAR FELLOWS

PROJECT CARE

Project CARE (CPR and Rescue Empowerment), previous Project HEART, is a student-run organization at JABSOM that aims to connect with local public high school students who are pursuing a healthcare career and enrich their education by providing mentorship, promoting healthy lifestyles, and teaching them skills that will translate to their future profession.

Monika Bernas, MD

Andrew Lee, MD

Kimberly Vu, MD

THIRD YEAR FELLOWS

Nath Limpruttidham, MD

Isaac Mizrahi, MD

James Zhang, MD

IN PROGRESS/FUTURE DIRECTIONS:

Increase high school visits to teach students about first aid, CPR, heart and lung physician exam, and different careers in the healthcare field Update the case-based curriculum to incorporate other healthcare roles such as EMTs, nurses, dietitians, and physical therapists Create a pamphlet with information about the education and training requirements for several healthcare careers, with emphasis on programs in Hawaii Develop a new partnership with AMR to teach CPR at health fairs in the community; received resources including CPR kits Expand our student team and created new leadership roles to direct our endeavors in connecting with more high schools, developing curriculum, and building relationships with community organizations 30

AMERICAN COLLEGE OF PHYSICIANS (ACP) HAWAI’I CHAPTER

The American College of Physicians (ACP) Hawai’i Chapter received the Gold Level of the 2023 Chapter Excellence Award. The award recognizes truly extraordinary chapters that surpass excellence in chapter management. We are in the company of 54 other outstanding chapters. In order to achieve the Gold Level of the Chapter Excellence Award, chapters must meet nineteen Bronze criteria, seventeen Silver criteria and multiple Gold level activities. Criteria include such activities as having a legislative action plan or agenda, holding a volunteerism/community service activity, holding multiple stand-alone meetings, having revenue sources outside of dues and meeting registration fees, implementing a strategic plan, implementing a formal recruitment and retention plan and measuring outcomes, conducting various activities for Medical Students, Residents and Early Career Physicians.

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2023 HAWAII CHAPTER ANNUAL SCIENTIFIC MEETING ABSTRACT COMPETITION WINNERS RESIDENT RESEARCH

First Place: Horyun Choi, MD "Phenobarbital for Alcohol Withdrawal: Systematic Review" Second Place: Andrew Pham, MD "The Role of Biomarkers in Predicting High Flow Nasal Cannula (HFNC) Success in COIVD-19 ARDS" Third Place: Maan Gozun, MD "Echocardiographic validity of the electrocardiographic diagnosis of left atrial enlargement in the elderly Asian population"

STUDENT RESEARCH First Place: Amanda Chau, MD "Mobility Device Use and Frailty Progression in Older Adults with Mobility Impairment" Second Place: Mikayla Sonnleitner, MD "Characteristics of Older Adults with Neurocognitive Screens in the Geriatric ED"

Positive

Third Place: Eduardo Biala, Jr., MD "Validation of the Edmonton Frail Scale-Acute Care in patients ≥ 65 years undergoing surgery"

Chapter Governor Dr. Sam Evans (left), Third Place Resident Research Winner Dr. Maan Gozun (center), and Program Chair Dr. Kuo-Chiang Lian (right).

TOP FELLOW RESEARCH PRESENTATION Gull Mahvish, MD "Improving Communication Skills Amongst Clinicians Through Formal Evidence Based Training"

TOP RESIDENT CASE PRESENTATION Helena Holmgren, MD "A Heart Stopping Case; Young Woman with Cardiac Tamponade, Right Atrial Mass, and Miliary Lung Nodules"

TOP MEDICAL STUDENT CASE PRESENTATION Shirley Cheng "Breast Nodular Fasciitis in a Postmenopausal Woman: A Case Report and Review of Recent Literature" 32

PAPAKOLEA ʻOHANA HEALTH FAIR

Our department recognizes the importance of community engagement and outreach in promoting health and wellness in Hawaii. Through partnerships with community organizations, and healthcare providers, we have been actively involved in health promotion activities, screenings, and educational seminars aimed at raising awareness about preventive health measures and disease management. Our participation in the Papakolea Ohana Health Fair each year brings together faculty, students, residents, and the community, providing an opportunity for all participants to exchange cultural and health practices.

The year 2023 has been marked by notable achievements and significant progress in the Department of Medicine. As we reflect on our accomplishments and challenges, we reaffirm our commitment to excellence, innovation, and service in the pursuit of improving human health and well-being. We extend our sincere gratitude to our faculty, staff, students, collaborators, and funding agencies for their dedication, support, and contributions to the success of the Department of Medicine research endeavors. Together, we are making a difference in advancing medical knowledge and improving the health and well-being of the people of Hawaii and beyond.

Looking ahead, the Department of Medicine is poised to continue its trajectory of excellence in research, education, and community engagement. We remain committed to addressing the evolving healthcare needs of our diverse population, fostering collaboration across disciplines, and translating research findings into tangible improvements in patient care and public health outcomes.

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CLINICAL FACULTY AWARDS

In appreciation of the enduring dedication of our Clinical Faculty Members towards our academic mission, the Department of Medicine has been honoring those who have volunteered on our faculty for more than 20 years. Service awards are being presented by medical students, residents, and other department members to recognize the extensive commitment of our longstanding Clinical Faculty.

Steven Azuma, MD 36 Years of Service

Gregory Howick, MD 33 Years of Service

Carmen Stanko, MD 37 Years of Service

Denny Bales, MD 36 Years of Service

Birendra Huja, MD 27 Years of Service

Alan Stein, MD 23 Years of Service

Jeffrey Berenberg, MD Elliot Kalauawa, MD 34 Years of Service 39 Years of Service

Jared Sugihara, MD 47 Years of Service

John Boyer, MD 24 Years of Service

Joseph Koo, MD 20 Years of Service

Thomas Tasaki, MD 34 Years of Service

Lisa Camara, MD 23 Years of Service

Matthew Lau, MD 28 Years of Service

Nadine Tenn Salle, MD 20 Years of Service

Monique Canonico, MD Jeffrey Liu, MD 24 Years of Service 28 Years of Service

Melvin Wong, MD 30 Years of Service

Boyuan Cao, MD 25 Years of Service

Ronald Morton, MD 34 Years of Service

Lisa Wong, MD 21 Years of Service

John Cogan, MD 22 Years of Service

Stuart Pang, MD 31 Years of Service

Royden Young, MD 21 Years of Service

Wayne Fujita, MD 22 Years of Service

Francis Pien, MD 20 Years of Service

Osamu Fukuyama, MD Robin Seto, MD 39 Years of Service 27 Years of Service

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ELIZABETH "LIZ" KEALI'IKUA'AINA TAM, M.D. MEMORIAL AWARD Inaugural Awardee - Reid Ikeda, MD Award Presented Wednesday, May 10th, 2023

Pictured Left to Right: Scott Kuwada, MD, AGAF, FACP (Department Interim Chair), Kaeo Tam (Dr. Tam's Brother), Reid Ikeda, MD, FACP (Awardee), Dee-Ann Carpenter, MD (Elizabeth Tam Committee Chair) Awarded to a JABSOM Department of Medicine faculty member who emulates the passion, grace, leadership, and dedication of Dr. Elizabeth “Liz” Keali‘ikua’āina Tam, who fostered lifelong learning in clinical care, research, and teaching while advocating for cultural humility and equity in medicine in addition to advancing lung health in Hawaii.

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RESEARCH

ENDEAVORS

The Department of Medicine at the University of Hawaii has continued to make significant strides in advancing medical knowledge, improving patient care, and fostering innovative research initiatives throughout the academic year 2022-2023. With a dedicated team of researchers, clinicians, and support staff, we have achieved notable successes in various areas of medical research, education, and community engagement. Our commitment to excellence in healthcare and scientific discovery remains unwavering as we navigate the challenges and opportunities of the ever-evolving landscape of medicine.

Prioritizing the reduction of health disparities among Hawaii’s diverse populations remains a core focus of our department. Through community-based participatory research and initiatives promoting health equity, we are actively engaged in efforts to diminish disparities in healthcare access and enhance health outcomes within underserved communities. Our faculty members within the Department of Medicine are actively participating in two significant research infrastructure and training grants funded by the National Institutes of Health (NIH): the Center for Pacific Innovations, Knowledge, and Opportunities (PIKO) and Ola HAWAII. These grants offer crucial funding and mentorship opportunities for early-career investigators, facilitating their growth and development as researchers.

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IN GRANT FUNDING RECEIVED THIS ACADEMIC YEAR

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PUBLICATIONS

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GRANTS

ANY OTHER INFO/ STATS? IMAGE?

DOM RESEARCH ENDEAVORS

2022-2023 BY THE NUMBERS

$4.31M+

CENTER FOR PACIFIC INNOVATIONS, KNOWLEDGE, AND OPPORTUNITIES (PIKO) Through funding from the Institutional Development Award Networks of Clinical and Translational Research (IDeACTR), the Center for PIKO has been established to foster the development and to facilitate the implementation of innovative and evidence-based clinical and translational (CTR) projects aimed at improving the health of Indigenous Pacific People (IPP, defined as Native Hawaiians, Pacific Islanders and Filipinos) and other underserved populations in Hawaii. The PIKO collaborative, which represents a partnership between the University of Hawaii (UH), Hawaii Pacific University (HPU), Chaminade University of Honolulu (CUH), and a large statewide network of 18 practice-based organizations (PBO) and other community-based organizations (CBO), will develop new and leverage existing resources to ensure real-world impact.

OLA HAWAII Achieving health and wellness for the communities in Hawaii, which suffer disproportionately from genetic, environmental and socio-economic disparities in health and healthcare access, is the rationale for the proposed Research Centers in Minority Institutions (RCMI) Specialized Center. The strategic goal of the Center, named Ola HAWAII, is to grow and support a community of health disparities investigators and collaborators (the “workforce”) to harness the power of diverse thought (the “thinkforce”) to determine the causes of and interventions for health disparities in the Pacific.

The Department of Medicine comprises three primary research units: (1) the Center for Cardiovascular Research, (2) the Hawai‘i Center for AIDS Research, and (3) the Magnetic Resonance Imaging Center.

Accomplishments from each of these units over the past year are detailed in the Highlights Section below.

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THE CENTER FOR CARDIOVASCULAR RESEARCH

The purpose of the Center for Cardiovascular Research (the CCR) is to train the next generation of cardiovascular investigators and produce a better understanding of cardiac disease. The CCR is a community of scientists that includes the labs of 5 principal investigators on the third floor of the BioScience Building at JABSOM: Drs. William Boisvert, Takashi Matsui, Ralph Shohet, Michelle Tallquist, and Ken Zhang. Several other faculty collaborate with these investigators and utilize resources of the Center including Drs. Olivier LeSaux, Noemi Polgar, Kathryn Shunke, Ben Fogelgren, and Mariana Gerschenson. Each laboratory has distinct areas of focus, Dr. Boisvert the immunology of atherosclerosis, Dr. Matsui signaling and programmed cell death, Dr. Shohet hypoxia and gene delivery, Dr. Tallquist the cardiac fibroblast, and Dr. Zhang the use of induced pluripotent cardiomyocytes to understand cardiac pathology. During fiscal year 2023 important accomplishments included 1. Continued or new grant funding, 2. Publications, and 3. Career progress of our trainees. We also provide echocardiography services to investigators doing cardiovascular research.

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GRANTS

Highlights include our T32 training grant, the first at the University, which has enabled us, over the past 10 years, to support three graduate students and three postdoctoral fellows every year.

During fiscal 2023 we submitted an application for a third 5-year cycle of funding which received an excellent score and will begin in August of 2024. This cycle will be led by Dr. Tallquist with Dr. Shohet serving as deputy director. This grant has also helped to inspire two subsequent successful T32 applications, one a collaboration between the Cancer Center and USC, and the other a collaboration between the School of Nutrition and the Bioinformatics Dept at JABSOM. Dr. Shohet has played an advisory role for both of these. Dr. Tallquist and Shohet also worked closely with Dr. Penner to submit a COBRE grant from Queens Medical Center (not funded) and with Dr. Shepherd to submit a joint COBRE John and Andrew are NHLBI K99 MOSAIC from the Cancer Center and JABSOM (under review). Other scholars, the first at the University. The award important grants have included continued success in funding the supports them as postdocs for two years and independence of our young investigators with two K99-R00 then with R01 level funding for three years as awards, the first to Andrew Knutson, a Native Hawaiian they embark on their independent careers. investigator in Dr. Shohet’s lab and a second to John Yap, a Native Hawaiian investigator with Dr. Boisvert, who has the additional distinction distinction of having completed his undergraduate and graduate education as a quadriplegic trainee. Dr. Matsui obtained HCF funding for his studies of how cell death can propagate down cardiac fibers in infarction. Dr. Zhang obtained funding from Ola Hawaii and has played a key role in recent submissions of the Bioinformatics T32 and COBRE applications. We have had extraordinary success in obtaining predoctoral and postdoctoral awards for our young investigators as well.

PUBLICATIONS

Dr. Tallquist’s group continued to work on cardiac fibrosis, lung development, and analysis of SARS-CoV-2 infection in lung fibrosis and testes dysfunction. This work resulted in three accepted and 4 submitted publications that are currently under review. Dr. Shohet had a publication on using a novel form of gene delivery to deliver Crispr constructs to the liver of mice as well as a joint publication with the GenTAC Registry investigators on vertebral tortuosity in Ehlers-Danlos Syndrome. Dr. Boisvert collaborated with the AIDS group on three publications on cardiovascular risk and with investigators in Spain on two publications relating to the relationship of body fat to atherosclerosis. This also led to a submitted R0-1. Dr. Matsui has continued to work on ferroptosis, publishing both a review article and book chapter in this area.

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These leaders of cardiology research met at the 6th annual International Hawaii Cardiovascular Symposium in February 2023.

The IHCVS is organized by Dr. Matsui of the CCR and Lorrie Kirshenbaum of the University of Manitoba.

TRAINING

Two of Dr. Tallquist’s students graduated in 2023. Jack Heckl is currently an MD/PhD at Caltech and the Kaiser Permanente School of Medicine. Jasmine Chen, an AHA pre-doctoral fellowship awardee, graduated in December 2023.

Dr. Shohet’s graduate student Katie Lee obtained an AHA predoc award for her thesis work on cardiac metabolism and his postdoc April Darrow received both an AHA postdoc award and an Ola Hawaii pilot award for her work on methamphetamine cardiomyopathy. All faculty participate in training of medical students with Drs. Tallquist, Matsui, and Shohet leading PBL groups. Dr. Matsui also organizes the annual International Hawaii Cardiovascular Symposium, that brings investigators from around the world to discuss recent basic advances in heart disease. Dr. Shohet also plays a role in our Cardiology Fellowship, based at Queens Medical Center, where he helps to admit, train, and evaluate clinical fellows.

ADMINISTRATIVE CONTRIBUTIONS

The faculty of the CCR provides a substantial amount of administrative leadership at the School. Dr. Tallquist in particular has served as Cell and Molecular Biology graduate chair, Institutional Biosafety Committee rep, Graduate Council rep, Undergraduate Research Opportunities Council rep, JABSOM Faculty Senate-vice chair, JABSOM curriculum committee, and Senate Executive Committee-vice chair. Dr. Matsui serves as Chair of Anatomy, Physiology, and Biochemistry. Dr. Boisvert serves on the Student Standing and Promotion Committee and has recently become interim Chair of Tropical Medicine. Dr. Shohet, who is the Director of the CCR, served on several tenure and promotion committees and is presently on the Dean Search Advisory Committee.

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HAWAI'I CENTER FOR AIDS RESEARCH (HICFA)

From left to right (top): Eduardo Manzano, Dr. Louie Gangcuangco, Nancy Hanks RN, Lorna Nagamine RN, Greg Milne, Dr. Dominic Chow (Director, Clint Spencer Clinic), Dr. Cecilia Shikuma (Director, HICFA), Debbie Ogata-Arakaki RN From left to right (bottom): Rachel Ouye, Diana Vares-Lum, Cris Milne APRN 42

The Hawaii Center for AIDS (HICFA is a University of Hawaii Board of Regents’ approved Center of Excellence for HIV research, training and care. HICFA maintains an office, a processing laboratory, and a clinic on the Kakaako campus which doubles both as research clinic space and space for our fee-for-service Clint Spencer HIV clinic. It is involved in the training of graduate students as well as medical students and residents. In research, laboratory research is conducted by 5 Dept of Tropical Medicine faculty affiliated with HICFA and clinical research activities by 3 Dept of Medicine faculty (C Shikuma, D Chow and L Gangcuangco). HICFA maintains an infrastructure for HIV clinical trials (research physicians, clinical research coordinators, processing lab, research pharmacist, research clinic space) and has a long history of providing patients living with HIV in Hawaii access to the latest HIV/AIDS antiretroviral therapy trials. Currently HICFA participates in Gilead’s phase 2 trial assessing the combination of oral weekly Islatravir in combination with Lenacapavir (GS-US-563-6041) to control HIV viremia. Over the past decade, as the health of this population has improved, HICFA’s primary HIV research focus has turned to the chronic age-related complications of HIV and the role of HIV immune activation is this process. We have published extensively on how monocyte/macrophage immune activation instigated by HIV contributes to the higher risk of cardiovascular disease and cognitive impairment in this population. HICFA now intends to address the final frontier of HIV research – that of HIV cure. It is in the early stages of planning a small collaborative early phase clinical trial involving 2 medications, auranofin and buthionine sulfoximine (BSO), intended to leverage the body’s antioxidant pathways to reduce the HIV latent reservoir. A research supply of BSO has been successfully obtained from the National Cancer Institute and a request for FDA IND is planned following re-analysis and re-vialing of BSO.

Front Sitting from left to right (HIV Cured Individuals): Marck Franke, “Dusseldorf Patient”; Adam Castillejo, “The London Patient”; Paul Edmonds,“City of Hope Patient” Back Standing from left to right: Dr. Louie Gangcuangco (Assistant Professor, Dept of Medicine), Timothy McCormick (Hawaii State Dept of Health), Dr. Thomas J. Hope (Northwestern University) Hawaii to Zero Conference, 2023

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HICFA conducts its research and care activities in close collaboration with the community and programs involved in assisting individuals with or at risk for HIV. This includes the State of Hawaii Department of Health Harm Reduction Branch and the state’s Ryan White and STD programs, community physicians and other health clinics involved in HIV care, and various AIDS Service Organizations (ASO) on Oahu and the neighbor islands. In September of 2023, with educational grant funding received from ViiV Healthcare, HICFA organized and held the 5th ‘Hawaii to Zero’ (H20; zero HIV deaths, zero new infections, zero stigma) conference, inviting 200 attendee to the Ala Moana Hotel for a full day of lectures from leaders in the field followed by community dialog on topics ranging from HIV prevention to optimal care of those infected to the possibility of HIV cure. Attendees included researchers, physicians, pharmacists, nurses, case managers and people living with and at risk for HIV from all islands. The highlight of this conference was the attendance of not one but THREE of the total of only 5 individuals in the world known to have been cured of HIV - Adam Castillejo, Marc Franke and Paul Edmonds. They shared their individual stories on stage about overcoming HIV and answered questions from the audience about how the cure has impacted them.

HICFA investigators, research associates, and staff at the 2023 Hawaii to Zero Conference: zero new HIV infections, zero HIV-related deaths, and zero stigma

In 2020 with the beginning of the COVID-19 pandemic, HICFA pivoted to take on research on SARS CoV2. Currently, some COVID related research projects HICFA is involved in include the national NIH-funded multi-center RECOVER cohort study (https://recovercovid.org/) designed to study the pathobiology of Long COVID; the 5 year Ola HAWAII project ‘Factors Responsible for the Development of Pulmonary Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) in Hawaii’ (Project MPI G Devendra, Assistant Professor Dept Medicine and J Park, Assistant Professor Dept of Tropical Medicine); the Leahi Foundation grant ‘Role of Anti-idiotype Autoantibodies (AA) directed against ACE2 in the Development of Pulmonary Post-Acute Sequelae of SARS-CoV2 Infection’ (PI C Shikuma); and the Angus Foundation grant ‘COVID-19 Infection in Hawaii’ (PI T Seto/C Shikuma).

HICFA’s clinical research/trials infrastructure serve as the Clinical Research Resource Cores for 2 research infrastructure grants at the medical school: Ola HAWAII (https://ola.jabsom.hawaii.edu/) and PIKO (https://piko.jabsom.hawaii.edu/).

This Core provides clinical research consultation for researchers interested in clinical research projects. Dr. Dominic Chow, JABSOM Professor of Medicine, serves as the Program Director of Ola HAWAII. HICFA is involved in 2 other initiatives important to promoting research in Hawaii. The Hawaii Clinical Research Network for Health Equity (NIMHD UG3MD08358; MPI C Shikuma, T Seto and V Balaraman) will merge the electronic health records (EHR) of the Queen’s Health System and Hawaii Pacific Health to create the beginnings of a de-identified Hawaiiwide Data Network that can be queried for research questions important to Hawaii and its population. This initial Data Network is anticipated to contain data on approximately 70% of Hawaii’s population. This grant will also initiate 2 projects at a community clinic level, at Kalihi Palama and Waikiki Health, focused on early detection of fatty liver disease utilizing portable FibroScans in our community’s health disparity population (Project PI C Tran, Assistant Professor Medicine) and in our HIV population (Project PI L Gangcuangco, Assistant Professor Medicine).

HICFA’s most recent initiative involves participation in the IDeA State Consortium for Clinical Research Resource Center (ISCORE-RC; NIGMS U24GM150446, PI S Hodder [West Virginia], Hawaii Site PI: C Shikuma). This grant intends to increase clinical trials in IDeA States (of which Hawaii is one) through communication of opportunities, effective marketing, and workforce development. Particularly exciting is the Clinical Research Coordinator training program to be offered by ISCORE-RC which will combine an extensive didactic on-line training program with a preceptor supervised hands-on clinical research experience locally in Hawaii. A certificate will be awarded following a final evaluation process.

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UNIVERSITY OF HAWAII

MAGNETIC RESONANCE RESEARCH CENTER (UHMRRC) The University of Hawaii Magnetic Resonance Research Center (UHMRRC) is located in the Department of Medicine at the John A. Burns School of Medicine (JABSOM). The UHMRRC has access to a 3 Tesla MRI scanner located at Queens Medical Center that has capabilities to perform whole body scans for both clinical and research purposes. The Center is staffed by two Medicine faculty V. Andrew Stenger, PhD and Christoph Rettenmeier, PhD and two staff members Zidan Yu, PhD and Steven Bucthal, PhD. All four members have extensive experience with the use of MRI for research and clinical applications. The faculty and staff are located on the 7th floor of the UH Medical Tower at the QMC campus.

Drs. Christoph Rettenmeier (left), V. Andrew Stenger (center), and Zidan Yu (right).

There are currently five NIH funded projects, one DOD funded project and one Hawaii Community Foundation project being run in the Center. These projects range from MRI methods development to the study of disease. A large focus is on the use of MRI to image brain function (fMRI) non-invasively in vivo (Stenger, Andres, Grills) for investigating drug addiction as well as mild traumatic brain injury, the latter of which is a collaboration between JABSOM and Tripler Army Medical Center. There are also three studies (Rettenemier, LeMarchand, Lim) for imaging liver fat and fibrosis to probe a range of diseases including NASH and links to cancer and dietary interventions. These involve collaborations between JABSOM, PBRC, and the UHCC. Finally, there is pilot study from the Hawaii Community Foundation (Matsui, JABSOM Department of Anatomy) to use diffusion MRI to probe heart disease.

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PUBLICATIONS

FACULTY CLINICAL FACULTY CVD FELLOWS RESIDENTS

1. Acoba JD, Hirano T, Nakasone R, Rho YS. Pancreatic cancer among Pacific Islanders: a comprehensive analysis of an understudied racial group. Ethn Health. 2023 Jul;28(5):650-660. doi: 10.1080/13557858.2022.2116631. Epub 2022 Aug 28. PMID: 36036201.

2. Acoba JD, Sumida K, Berenberg J. Overcoming racial disparities in cancer clinical trial enrollment of Asians and Native Hawaiians.

Contemp Clin Trials Commun. 2022 May 27;28:100933. doi: 10.1016/j.conctc.2022.100933. PMID: 36688088; PMCID: PMC9846448.

3. Acoba JD, Yin C, Meno M, Abe J, Pagano I, Tamashiro S, Fujinaga K, Braun-Inglis C, Fukui J. Racial Disparities in Patient-Provider Communication During Telehealth Visits Versus Face-to-face Visits Among Asian and Native Hawaiian and Other Pacific Islander Patients With Cancer: Cross-sectional Analysis. JMIR Cancer. 2022 Dec 9;8(4):e37272. doi: 10.2196/37272. PMID: 36485021; PMCID: PMC9789492.

4. Asante I, Lu A, Mitchell BI, Boisvert WA, Shikuma CM, Chow DC, Louie SG. Alterations in Renin-Angiotensin System (RAS) Peptide Levels in Patients with HIV. Metabolites. 2022 Dec 31;13(1):61. doi: 10.3390/metabo13010061. PMID: 36676986; PMCID: PMC9860813.

5. Bennett JP, Liu YE, Quon BK, Kelly NN, Leong LT, Wong MC, Kennedy SF, Chow DC, Garber AK, Weiss EJ, Heymsfield SB, Shepherd JA. Threedimensional optical body shape and features improve prediction of metabolic disease risk in a diverse sample of adults. Obesity (Silver Spring).

2022 Aug;30(8):1589-1598. doi: 10.1002/oby.23470. PMID: 35894079; PMCID: PMC9333197.

6. Berg BW. Simulation: past, present, and future. Clin Exp Emerg Med. 2023 Jun;10(2):125-128. doi: 10.15441/ceem.23.044. Epub 2023 Apr 24. PMID: 37095704; PMCID: PMC10350354.

7. Bhagavathula AS, Bansil S, Nishimura Y. Google Trends in Breast and Cervical Cancer Searches From 2008 to 2021: An Infodemiology Study.

Cureus. 2023 May 15;15(5):e39035. doi: 10.7759/cureus.39035. PMID: 37323300; PMCID: PMC10266303.

8. Chin JM, Chen E, Wright T, Bravo RM, Nakashima E, Kiyokawa M, Karasaki K, Estrada P, Ghatnekar R, Lee MJ, Bartholomew ML. Urine drug screening on labor and delivery. Am J Obstet Gynecol MFM. 2022 Nov;4(6):100733. doi: 10.1016/j.ajogmf.2022.100733. Epub 2022 Aug 26.

PMID: 36038068.

9. Chow DC, Saiki KMW, Siriwardhana C, Lozano Gerona J, Vanapruks S, Ogle J, Premeaux TA, Ndhlovu LC, Boisvert WA. Increased Transmigration of Intermediate Monocytes Associated with Atherosclerotic Burden in People with HIV on Antiretroviral Therapy. AIDS. 2023 Jun 1;37(7):1177-1179. doi:10.1097/QAD.0000000000003534. Epub 2023 Mar 3. PMID: 36927653.

10. Cobb MS, Tao S, Shortt K, Girgis M, Hauptman J, Schriewer J, Chin Z, Dorfman E, Campbell K, Heruth DP, Shohet RV, Dawn B, Konorev EA. Smad3 promotes adverse cardiovascular remodeling and dysfunction in doxorubicin-treated hearts. Am J Physiol Heart Circ Physiol. 2022 Dec 1;323(6):H1091-H1107. doi: 10.1152/ajpheart.00312.2022. Epub 2022 Oct 21. PMID: 36269647; PMCID: PMC9678413.

11. Czech T, Shah P, Lee G, Watanabe G, Ogasawara C, Noh T. Cerebral toxoplasmosis in a patient with combined variable immunodeficiency.

Surg Neurol Int. 2022 Aug 12;13:354. doi: 10.25259/SNI_532_2022. PMID: 36128152; PMCID: PMC9479566.

12. Czech T, Sugihara S, Nishimura Y. Characteristics of hair loss after COVID-19: A systematic scoping review. J Cosmet Dermatol. 2022 Sep;21(9):3655-3662. doi: 10.1111/jocd.15218. Epub 2022 Jul 19. PMID: 35801366; PMCID: PMC9349634.

13. Dean LS, Chow DC, Ndhlovu LC, Boisvert WA, Chang SP, Shikuma CM, Park J. Characterization of Circulating Fibrocytes in People Living with HIV on Stable Antiretroviral Therapy. Immunohorizons. 2022 Nov 1;6(11):760-767. doi: 10.4049/immunohorizons.2200085. PMID: 36445359; PMCID: PMC10402248.

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14. Dean LS, Devendra G, Jiyarom B, Subia N, Tallquist MD, Nerurkar VR, Chang SP, Chow DC, Shikuma CM, Park J. Phenotypic alteration of low-density granulocytes in people with pulmonary post-acute sequalae of SARS-CoV-2 infection. Front Immunol. 2022 Dec 15;13:1076724. doi: 10.3389/fimmu.2022.1076724. Erratum in: Front Immunol. 2023 Apr 28;14:1209624. PMID: 36591237; PMCID: PMC9797994.

15. Di Stefano L, Ogburn EL, Ram M, Scharfstein DO, Li T, Khanal P, Baksh SN, McBee N, Gruber J, Gildea MR, Clark MR, Goldenberg NA, Bennani Y, Brown SM, Buckel WR, Clement ME, Mulligan MJ, O'Halloran JA, Rauseo AM, Self WH, Semler MW, Seto T, Stout JE, Ulrich RJ, Victory J, Bierer BE, Hanley DF, Freilich D. Hydroxychloroquine/chloroquine for the treatment of hospitalized patients with COVID-19: An individual participant data meta-analysis. PLoS One. 2022;17(9):e0273526. doi: 10.1371/journal.pone.0273526. eCollection 2022. PubMed PMID: 36173983; PubMed Central PMCID: PMC9521809.

16. Di Stefano L, Ogburn EL, Ram M, Scharfstein DO, Li T, Khanal P, Baksh SN, McBee N, Gruber J, Gildea MR, Clark MR, Goldenberg NA, Bennani Y, Brown SM, Buckel WR, Clement ME, Mulligan MJ, O'Halloran JA, Rauseo AM, Self WH, Semler MW, Seto T, Stout JE, Ulrich RJ, Victory J, Bierer BE, Hanley DF, Freilich D; Pandemic Response COVID-19 Research Collaboration Platform for HCQ/CQ Pooled Analyses.

Hydroxychloroquine/chloroquine for the treatment of hospitalized patients with COVID-19: An individual participant data meta-analysis. PLoS One. 2022 Sep 29;17(9):e0273526. doi: 10.1371/journal.pone.0273526. PMID: 36173983; PMCID: PMC9521809.

17. Donlon TA, Morris BJ, Masaki KH, Chen R, Davy PMC, Kallianpur KJ, Nakagawa K, Owens JB, Willcox DC, Allsopp RC, Willcox BJ. FOXO3, a Resilience Gene: Impact on Lifespan, Healthspan, and Deathspan. J Gerontol A Biol Sci Med Sci. 2022 Aug 12;77(8):1479-1484. doi: 10.1093/gerona/glac132. PMID: 35960854; PMCID: PMC9373965.

18. Estaris J, Bansil S, Nishimura Y. Steroid-Responsive Encephalopathy Associated With Autoimmune Thyroiditis Masquerading Sepsis.

Cureus. 2023 May 10;15(5):e38826. doi: 10.7759/cureus.38826. PMID: 37303426; PMCID: PMC10252151.

19. Fujii-Lau LL, Thosani NC, Al-Haddad M, Acoba J, Wray CJ, Zvavanjanja R, Amateau SK, Buxbaum JL, Wani S, Calderwood AH, Chalhoub JM, Coelho-Prabhu N, Desai M, Elhanafi SE, Fishman DS, Forbes N, Jamil LH, Jue TL, Kohli DR, Kwon RS, Law JK, Lee JK, Machicado JD, Marya NB, Pawa S, Ruan W, Sawhney MS, Sheth SG, Storm A, Thiruvengadam NR, Qumseya BJ; (ASGE Standards of Practice Committee Chair [20202023]). American Society for Gastrointestinal Endoscopy guideline on role of endoscopy in the diagnosis of malignancy in biliary strictures of undetermined etiology: methodology and review of evidence. Gastrointest Endosc. 2023 Nov;98(5):694-712.e8. doi: 0.1016/j.gie.2023.06.007.

Epub 2023 Jun 10. PMID: 37307901.

20. Gangcuangco LMA, Rivas T, Basnet A, Ryu DY, Qaiser M, Usman R, Costales VC. Factors associated with colorectal cancer screening adherence and the impact of COVID-19 on screening patterns in Connecticut, USA. Intern Emerg Med. 2022 Nov;17(8):2229-2235. doi: 10.1007/s11739-022-03053-2. Epub 2022 Aug 3. PMID: 35922730; PMCID: PMC9362104.

21. Gangcuangco LMA, Eustaquio PC. The State of the HIV Epidemic in the Philippines: Progress and Challenges in 2023. Trop Med Infect Dis. 2023 Apr 30;8(5):258. doi: 10.3390/tropicalmed8050258. PMID: 37235306; PMCID: PMC10224495.

22. Giannakopoulos S, Strange DP, Jiyarom B, Abdelaal O, Bradshaw AW, Nerurkar VR, Ward MA, Bakse J, Yap J, Vanapruks S, Boisvert WA, Tallquist MD, Shikuma C, Sadri-Ardekani H, Clapp P, Murphy SV, Verma S. In vitro evidence against productive SARS-CoV-2 infection of human testicular cells: Bystander effects of infection mediate testicular injury. PLoS Pathog. 2023 May 18;19(5):e1011409. doi: 10.1371/journal.ppat.1011409. PMID: 37200377; PMCID: PMC10231791.

23. Gozun M, Keitoku K, Kimura N, Sawada H, Pham A, Yeo J, Hagiya H, Nishimura Y. Cefepime-induced neurotoxicity: systematic review. J Antimicrob Chemother. 2022 Oct 28;77(11):2908-2921. doi: 10.1093/jac/dkac271. PMID: 35971666.

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24. Ha G, Kwong K, Tanaka B, Nishimura Y, Chong C. Are Patients with HHV-8 Associated Castleman Disease Successfully Treated with Rituximab at Risk of Subsequently Developing HHV-8 Negative (Idiopathic) Castleman Disease? Eur J Case Rep Intern Med. 2023 Jun 20;10(7):003904. doi: 10.12890/2023_003904. PMID: 37455698; PMCID: PMC10348438.

25. Hedges JR, Chow DC, Fogelgren B, Braun KL, Tsark JU, Ordinado S, Berry MJ, Yanagihara R, Mokuau N. Health Disparities Investigator Development through a Team-Science Pilot Projects Program. Int J Environ Res Public Health. 2023 Mar 30;20(7):5336. doi: 10.3390/ijerph20075336. PMID: 37047951; PMCID: PMC10094603.

26. Hirami Y, Nishimura MF, Urata T, Morimoto M, Maekawa Y, Yoshino T, Nishimura Y, Sato Y. Comparison of serum sIL-2R and LDH levels in patients with intravascular large B-cell lymphoma and patients with advanced stage diffuse large B-cell lymphoma. J Clin Exp Hematop. 2023 Mar 28;63(1):25-31. doi: 10.3960/jslrt.22043. Epub 2023 Mar 26. PMID: 36843068; PMCID: PMC10158718.

27. Ing CT, Clemens B, Ahn HJ, Kaholokula JK, Hovmand PS, Seto TB, Novotny R. Food Insecurity and Blood Pressure in a Multiethnic Population. Int J Environ Res Public Health. 2023 Jun 28;20(13). doi: 10.3390/ijerph20136242. PubMed PMID: 37444090; PubMed Central PMCID: PMC10341426.

28. Jujo S, Sakka BI, Lee-Jayaram JJ, Kataoka A, Izumo M, Kusunose K, Nakahira A, Oikawa S, Kataoka Y, Berg BW. Medical student mediumterm skill retention following cardiac point-of-care ultrasound training based on the American Society of Echocardiography curriculum framework. Cardiovasc Ultrasound. 2022 Oct 12;20(1):26. doi: 10.1186/s12947-022-00296-z. PMID: 36224597; PMCID: PMC9554392.

29. Kandah F, Deol T, Dhruva P, Chandler Z, Musa T, Velarde G. A Case of Postpartum Takotsubo (Stress) Cardiomyopathy. Case Rep Cardiol.

2022 Aug 4;2022:4739742. doi: 10.1155/2022/4739742. PMID: 35967747; PMCID: PMC9371808.

30. Khawaja M, Qadeer YK, Siddiqui R, Chelu MG, Aiumtrakul N, Pickett JK, Brugada R, Brugada J, Brugada P, Krittanawong C. Brugada Syndrome within Asian Populations: State-of-the-Art Review. Cardiogenetics. 2023; 13(2):61-74. doi: 10.3390/cardiogenetics13020007.

31. Kiyokawa M, Quattlebaum THN. Implications for a System of Care in Hawai'i: Primary Care Integration of Substance Use Disorder Treatment. Hawaii J Health Soc Welf. 2022 Dec;81(12 Suppl 3):62-68. PMID: 36660279; PMCID: PMC9783814.

32. Kozai L, Nishimura Y. Clinical characteristics of blue rubber bleb nevus syndrome in adults: systematic scoping review. Scand J Gastroenterol. 2023 Jul-Dec;58(10):1108-1114. doi: 10.1080/00365521.2023.2214263. Epub 2023 May 21. PMID: 37211745.

33. Kozai L, Tan A, Nebrejas KE, Warashina C, Nishimura Y. Collagenous Gastritis Is an Underdiagnosed Cause of Anemia and Abdominal Pain: Systematic Scoping Review. Dig Dis Sci. 2023 Jul;68(7):3103-3114. doi: 10.1007/s10620-023-07938-w. Epub 2023 Apr 6. PMID: 37022603.

34. Kreidieh O, Varley AL, Romero J, Singh D, Silverstein J, Thosani A, Varosy P, Hebsur S, Godfrey BE, Schrappe G, Justice L, Zei PC, Osorio J. Practice Patterns of Operators Participating in the Real-World Experience of Catheter Ablation for Treatment of Symptomatic Paroxysmal and Persistent Atrial Fibrillation (REAL-AF) Registry. J Interv Card Electrophysiol. 2022 Nov;65(2):429-440. doi: 10.1007/s10840-022-01205-0.

Epub 2022 Apr 19. PMID: 35438393.

35.Kuniyoshi J, Kwock M, Silangcruz K, Techasatian W, Nishimura Y. THE CHATTERJEE PHENOMENON: A DEMONSTRATION OF CARDIAC MEMORY IN PACED RHYTHMS. Eur J Case Rep Intern Med. 2023 Mar 3;10(3):003798. doi: 10.12890/2023_003798. PMID: 36969518; PMCID: PMC10035617.

36.KuwabaraJT,HaraA,BhutadaS,GojanovichGS,ChenJ,HokutanK,ShettigarV,LeeAY,DeAngeloLP,HecklJR,Jahansooz JR, Tacdol DK, Ziolo MT, Apte SS, Tallquist MD. Consequences of PDGFRα+ fibroblast reduction in adult murine hearts. Elife. 2022 Sep 23;11:e69854. doi: 10.7554/eLife.69854. PMID: 36149056; PMCID: PMC9576271.

37. Kuwabara JT, Hara A, Heckl JR, Peñ a B, Bhutada S, DeMaris R, Ivey MJ, DeAngelo LP, Liu X, Park J, Jahansooz JR, Mestroni L, McKinsey TA, Apte SS, Tallquist MD. Regulation of extracellular matrix composition by fibroblasts during perinatal cardiac maturation. J Mol Cell Cardiol.

2022 Aug;169:84-95. doi: 10.1016/j.yjmcc.2022.05.003. Epub 2022 May 13. PMID: 35569524; PMCID: PMC10149041.

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38. Kwee SA, Wong LL, Ludema C, Deng CK, Taira D, Seto T, Landsittel D. Target Trial Emulation: ADesign Tool for Cancer Clinical Trials. JCO Clin Cancer Inform. 2023 Jan;7:e2200140. doi: 10.1200/CCI.22.00140. PubMed PMID: 36608311; PubMed Central PMCID: PMC10166475.

39. Lee AY, Kuwada SK. Use of an over-the-scope clip in managing adult anastomotic ulcer bleeding. J Surg Case Rep. 2023 Jun 30;2023(6):rjad350. doi: 10.1093/jscr/rjad350. PMID: 37397066; PMCID: PMC10314710.

40. Luu JM, Wei J, Shufelt CL, Asif A, Tjoe B, Theriot P, Bairey Merz CN. Clinical Practice Variations in the Management of Ischemia With No Obstructive Coronary Artery Disease. J Am Heart Assoc. 2022 Oct 4;11(19):e022573. doi: 10.1161/JAHA.121.022573. Epub 2022 Sep 29.

PMID: 36172938; PMCID: PMC9673699.

41. Mahfouz R, Douglas MF, Obeidat AE, Darweesh M, Mansour MM, Shah P, Aldiabat M, Aljabiri Y, Fishman A. Impact of Atrial Fibrillation on Patients With Inflammatory Bowel Disease Admitted for Colectomy. Cureus. 2022 Aug 10;14(8):e27849. doi: 10.7759/cureus.27849. PMID: 36110442; PMCID: PMC9462059.

42.Miyoshi T, Ida H, Nishimura Y, Ako S, Otsuka F. Effects of Yoga and Mindfulness Programs on Self-Compassion in Medical Professionals during the COVID-19 Pandemic: An Intervention Study. Int J Environ Res Public Health. 2022 Sep 30;19(19):12523. doi: 10.3390/ijerph191912523. PMID: 36231820; PMCID: PMC9566664.

43. Nakagawa K, Chen R, Greenberg SM, Ross GW, Willcox BJ, Donlon TA, Allsopp RC, Willcox DC, Morris BJ, Masaki KH. Forkhead box O3 longevity genotype may attenuate the impact of hypertension on risk of intracerebral haemorrhage. J Hypertens. 2022 Nov 1;40(11):22302235. doi: 10.1097/HJH.0000000000003249. Epub 2022 Aug 3. PMID: 35943066; PMCID: PMC9553272.

44. Nguyen TB, Lac Q, Abdi L, Banerjee D, Deng Y, Zhang Y. Harshening stem cell research and precision medicine: The states of human pluripotent cells stem cell repository diversity, and racial and sex differences in transcriptomes. Front Cell Dev Biol. 2023 Jan 4;10:1071243. doi: 10.3389/fcell.2022.1071243. PMID: 36684445; PMCID: PMC9848738.

45. Nishikori A, Nishimura MF, Nishimura Y, Otsuka F, Maehama K, Ohsawa K, Momose S, Nakamura N, Sato Y. Idiopathic Plasmacytic Lymphadenopathy Forms an Independent Subtype of Idiopathic Multicentric Castleman Disease. Int J Mol Sci. 2022 Sep 7;23(18):10301. doi: 10.3390/ijms231810301. PMID: 36142213; PMCID: PMC9499480.

46. Nishimura Y, Choi H, Colgan B, Kistler H, Mercado F. Current evidence and clinical utility of phenobarbital for alcohol withdrawal syndrome. Eur J Intern Med. 2023 Jun;112:52-61. doi: 10.1016/j.ejim.2023.03.006. Epub 2023 Mar 21. PMID: 36935249.

47. Nishimura Y. Daptomycin-Related Rhabdomyolysis Complicated by Severe Hyperkalemia and Acute Kidney Injury. Cureus. 2022 Sep 29;14(9):e29764. doi: 10.7759/cureus.29764. PMID: 36324366; PMCID: PMC9617813.

48. Nishimura Y. Primary Care, Burnout, and Patient Safety: Way to Eliminate Avoidable Harm. Int J Environ Res Public Health. 2022 Aug 16;19(16):10112. doi: 10.3390/ijerph191610112. PMID: 36011747; PMCID: PMC9408659.

49. Obeidat A, Silangcruz K, Kozai L, Wien E, Fujiwara Y, Nishimura Y. Clinical Characteristics and Outcomes of Gastritis Associated With Immune Checkpoint Inhibitors: Scoping Review. J Immunother. 2022 Oct 1;45(8):363-369. doi: 10.1097/CJI.0000000000000435. Epub 2022 Aug 16. PMID: 35972801.

50. Pan D, Li C, Wu S, Ma L. Surgical Treatment & Long-term Follow Up of Giant Spherical Coronary Artery Aneurysm with Fistula to Left Ventricle: A Case Report. Heart Surg Forum. 2022 Sep 28;25(5):E674-E675. doi: 10.1532/hsf.4959. PMID: 36317899.

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51. Park J, Dean LS, Jiyarom B, Gangcuangco LM, Shah P, Awamura T, Ching LL, Nerurkar VR, Chow DC, Igno F, Shikuma CM, Devendra G. Elevated circulating monocytes and monocyte activation in COVID-19 convalescent individuals. Front Immunol 2023 Apr 3;14:1151780. doi: 10.3389/fimmu.2023.1151780. eCollection 2023. PMID: 37077911 PMCID: PMC10106598.

52. RECOVER Consortium (Chow D). Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection. JAMA. 2023 Jun 13;329(22):1934-1946. doi: 10.1001/jama.2023.8823. PMID: 37278994; PMCID: PMC10214179.

53. RECOVER Consortium (D Chow). Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design. PLoS One. 2023 Jun 23;18(6):e0286297. doi: 10.1371/journal.pone.0286297. eCollection 2023.PMID: 37352211.

54. Sawada H, Czech T, Silangcruz K, Kozai L, Obeidat A, Wien EA, Nishimura MF, Nishikori A, Sato Y, Nishimura Y. Clinicopathological characteristics of gastric IgG4-related disease: Systematic scoping review. J Gastroenterol Hepatol. 2022 Oct;37(10):1865-1872. doi: 10.1111/jgh.15980. Epub 2022 Aug 21. PMID: 35949057.

55. Sentell TL, Agner JL, Davis J, Mannem S, Seto TB, Valente TW, Vawer M, Taira DA. Social networks in patients hospitalized with preventable conditions for heart disease and diabetes in Hawai'i by health literacy. Chronic Illn. 2022 Sep;18(3):517-531. doi: 10.1177/1742395320987892. Epub 2021 Jan 26. PMID: 33497289.

56. Seto BK, Nishizaki L, Akaka G, Kimura JA, Seto TB. Differences in COVID-19 Hospitalizations by Self-Reported Race and Ethnicity in a Hospital in Honolulu, Hawaii. Prev Chronic Dis. 2022 Nov 17;19:E72. doi: 10.5888/pcd19.220114. PMID: 36395004; PMCID: PMC9673976.

57. Shah P, Benavente K, Yeo J, Czech T, Techasatian W, Daoud EG. Diaphragmatic Pacing in Spinal Cord Injury. J Mech Vent 2022; 3(2):63-71. doi: 10.53097/JMV.10049.

58. Shah P, Chock M, Nishimura Y, et al. Ciprofloxacin-induced crystal nephropathy and allergic interstitial nephritis: Case report and Review Of literature. AIM Clinical Cases. 2022;1:e220243. doi: 10.7326/aimcc.2022.0243.

59. Takashiki R, Komatsu J, Nowicki M, Moritoki Y, Okazaki M, Ohshima S, Hasegawa H, Nomura K, Ouchi G, Berg BW, Shirakawa H, Nakayama K, Takahashi N. Improving performance and self-efficacy of novice nurses using hybrid simulation-based mastery learning. Jpn J Nurs Sci. 2023 Apr;20(2):e12519. doi: 10.1111/jjns.12519. Epub 2022 Nov 21. PMID: 36410049.

60. Tanariyakul M, Chang B, Keitoku K, Su M, Hagiya H, Nishimura Y. Clinical Characteristics of Strongyloidiasis during the COVID-19 Pandemic: Systematic Scoping Review. Am J Trop Med Hyg. 2023 Mar 20;108(5):901-905. doi: 10.4269/ajtmh.22-0671. PMID: 36940666; PMCID: PMC10160902.

61.Techasatian W, Gozun M, Morihara C, Pham A, Benavente K, Nagamine T, Nishimura Y. Hamartoma of mature cardiac myocytes: systematic review. Cardiovasc Pathol. 2023 Jul-Aug;65:107538. doi: 10.1016/j.carpath.2023.107538. Epub 2023 Apr 7. PMID: 37031829.

62. Tokumasu K, Nishimura Y, Sakamoto Y, Obika M, Kataoka H, Otsuka F. Differences in Stress Perception of Medical Students Depending on In-Person Communication and Online Communication during the COVID-19 Pandemic: A Japanese Cross-Sectional Survey. Int J Environ Res Public Health. 2023 Jan 15;20(2):1579. doi: 10.3390/ijerph20021579. PMID: 36674333; PMCID: PMC9865011.

63. Umbarkar P, Tousif S, Singh AP, Anderson JC, Zhang Q, Tallquist MD, Woodgett J, Lal H. Fibroblast GSK-3α Promotes Fibrosis via RAF-MEKERK Pathway in the Injured Heart. Circ Res. 2022 Sep 16;131(7):620-636. doi: 10.1161/CIRCRESAHA.122.321431. Epub 2022 Sep 2. PMID: 36052698; PMCID: PMC9481711.

64. Umei N, Nishimura M, Ichiba S, Sakamoto A, Berg BW. The Need for an Adult Intensive Care Unit Boot Camp for Residents and Fellows: A Cross-Sectional Survey among Intensive Care Unit Directors. J Nippon Med Sch. 2022 Aug 27;89(4):443-453. doi: 10.1272/jnms.JNMS.2022_89-412. Epub 2022 May 30. PMID: 35644548.

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65. Veillet-Chowdhury M, Dabbagh GS, Benton SM Jr, Hill AM, Lee JH, Singleton MJ, Fazio GP, Harvey JE, Samady H, Singh D, Khanji MY, Nazarian S, Pugliese F, Obeng-Gyimah E, Schuler BT, Chahal CAA. CT-Guided Direct Current Cardioversion for Atrial Arrhythmias During the COVID-19 Pandemic. JACC Cardiovasc Imaging. 2023 Jan;16(1):135-137. doi: 10.1016/j.jcmg.2022.08.009. Epub 2022 Oct 19. PMID: 36599561.

66. Vo K, Nishimura Y, Yokoyama J, Wasko A, Miyake T, Vu K, Zhang J, Pino Moreno J, Banerjee D, Kim L, Chong C. Eosinophilic Myocarditis Presenting as Cardiac Tamponade: A Diagnostic Challenge. Eur J Case Rep Intern Med. 2022 Sep 20;9(9):003564. doi: 10.12890/2022_003564. PMID: 36299841; PMCID: PMC9586496.

67. Wieland J, Quinn K, Stenger K, Cheng S, Acoba J. Patient Understanding of Oncologic Radiology Reports: Is Access to Electronic Medical Records Helpful? J Cancer Educ. 2023 Jun;38(3):895-899. doi: 10.1007/s13187-022-02204-5. Epub 2022 Aug 19. PMID: 35984630.

68. Yagi MS, Numanoi S, Matsumoto Y, Masuda M, Berg BW. Factors facilitating independent training using human patient simulators for nursing students, Journal of Clinical Simulation Research (Japan), 2022, Volume 9, Pages 3-11. doi:10.57441/jcsr.9.0_3.

69.Ye Y, Noche RB, Szejko N, Both CP, Acosta JN, Leasure AC, Brown SC, Sheth KN, Gill TM, Zhao H, Falcone GJ. A genome-wide association study of frailty identifies significant genetic correlation with neuropsychiatric, cardiovascular, and inflammation pathways. Geroscience. 2023 Aug;45(4):2511-2523. doi: 10.1007/s11357-023-00771-z. Epub 2023 Mar 16. PMID: 36928559; PMCID: PMC10651618.

70. Yeo J, Shah P, Keitoku K, Gozun M, Franck CL, Daoud EG. Mechanical power in AVM-2 versus conventional ventilation modes in various ARDS lung models: A bench study. J Mech Vent 2022; 3(3):110-122. doi: 10.53097/JMV.10056.

71. Yu Z, Chen S, Tang Z, Tang Y, Ling Z, Wang H, Gong T, Gao Z, Devendra G, Huang G, Chen W, Deng Y. Mitochondria-derived small RNAs as diagnostic biomarkers in lung cancer patients through a novel ratio-based expression analysis methodology. Genes Dis. 2022 Aug 7;10(3):1055-1061. doi: 10.1016/j.gendis.2022.07.013. PMID: 37396544; PMCID: PMC10308114.

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GRANTS

FACULTY CLINICAL FACULTY

1. Administrative Supplements to Enhance Inclusion of Native Hawaiian/Other Pacific Islander Populations in Minority Health and Health Disparities Research. PI: Chow D. Funded by NIH; $125,000 awarded on 9/1/2021; project period 9/1/21 - 8/30/2024.

2. American Lung Association of Hawaii and Leahi Fund Endowed Chair in Respiratory Health (research). Director: Ikeda R. Funded locally; $40,000 awarded on 9/23/2022; project period 9/24/2022 - 6/30/2024.

3. A Phase 2 Randomized, Open-Label, Active-Controlled Study Evaluating the Safety and Efficacy of an Oral Weekly Regimen of Islatravir in Combination With Lenacapavir in Virologically Suppressed… (non-research). PI: Shikuma C. Funded by Gilead Sciences, Inc.; $4,10,416 awarded on 4/28/2023; project period 3/16/2023 - 11/30/2026.

4. Association of microbiome on blood pressure and hypertension in HIV participants on suppressive antiretroviral therapy (research). PI: Chow D. Locally funded; $30,000 awarded on 5/1/2020; project period 5/1/2020 - 4/30/2023.

5. Cardiovascular Complications of HIV (HRSA). Co-PI: Seidel Tallquist M. Funded by NIH; $800,000 awarded on 8/18/2018; project period 8/18/2018 - 6/30/2023.

6. Cell-to-cell death along myofibers in ischemic heart disease (research). Other: Rettenmeier C. Funded locally; $60,000 awarded on 7/1/2022; project period 7/1/2022 - 1/1/2024.

7. COBRE-Diabetes in NCE (research). Pilot Project Coordinator: Shohet R. Funded by NIH; $1,500,000 awarded on 8/1/2012; project period 8/1/2012 - 7/31/2022.

8. COBRE-Diabetes Pilot Project (research). PI: Brown S. Funded by UH; $50,000 awarded on 6/20/2022; project period 8/1/2023 7/31/2024.

9. COVID-19 Infection in Hawaii (research). Co-PI: Chow D. Local funding; $150,000 awarded on 9/1/2021; project period 10/1/2022 3/30/2024.

10. Creative Pedagogy Award (research). PI: Miles J. Funded by UH; $3,000 awarded on 4/30/2023; project period 7/1/2023-6/30/2024.

11. Development and Validation of a Novel Tool to Assess Sodium Intake for Heart Disease Prevention in a Multiethnic Population (research). Other: Seto T. Funded locally; $59,190 awarded on 7/1/2022; project period 7/1/2022 - 1/1/2024.

12. Directed evolution of a sequence-specific targeting technology… (research). Other: Shohet R. Funded by NIH; awarded on 4/1/2021; project period 4/1/2021 - 3/31/2025.

13. Effect of Immulina Supplements on Inflammatory Biomarkers Correlated With Clinical Symptoms in Patients With Long COVID (PASC) (research). PI: Shikuma C. Funded by the University of Mississippi; $12,500 awarded on 1/17/2024; project period 12/1/2022 7/31/2023.

14. Effects of Intermittent Energy Restriction on Intra-Abdominal Fat and the Gut Microbiome: A Randomized Trial (research). Other: Stenger, A. PI: LeMerchand. Funded by NIH, $2,500,000 awarded on 9/21/2021; project period 9/21/2021 - 8/31/2026.

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15. Evaluation of treatment predictors reflecting beta-catenin activation in hepatocellular carcinoma (research). Other: Rettenmeier C. Funded by NIH; $2,600,000 awarded on 6/24/2021; project period 07/01/2021 - 06/30/2026.

16. Facilitators and barriers to implementation of a pilot methamphetamine treatment program at a Level I trauma center (research). Co-I: Kiyokawa M. Funded locally. $14,575 awarded on 6/13/2022; project period 7/1/2022 - 1/1/2024.

17. Factors Responsible for the Development of Pulmonary Post-Acute Sequelae of SARS-CoV-2 Infection (PPASC) in Hawaii (research). PI: Devendra G. Funded by NIH; $300,000 awarded on 9/1/2022; project period 9/1/2022 - 5/31/2027.

18. Hawai’i Clinical Research Network for Health Equity (research). PI: Shikuma C. Co-PI: Seto T. Other: Gangcuangco L. Funded by NIH; $3,105,250 awarded on 9/23/2022; project period 9/24/2022 - 6/30/2024.

19. Hawai’i Health Equity Research and Outreach Network (HAWAI’I HERON) (research). Co-PI: Seto T. Funded by FDA; $550,000 awarded on 6/1/2023; project period 6/1/2023 - 5/31/2025.

20. Hawaii Interdisciplinary Mentored Career Development in HIV Co-Morbidities (training). Co-PI: Seto T. Funded by NIH; $1,558,000 awarded on 8/1/2018 project period 8/1/2018 - 6/30/2024.

21. Hawaii Pacific Islands Mammography Registry (research). Other: Seto T. Funded by NIH; $165,360 awarded on 4/1/2023; project period 4/1/2023 - 3/31/2028.

22. Hawaii to Zero (non-research). PI: Shikuma C. Funded by Viiv healthcare; $94,954 awarded on 5/4/2023; project period 3/24/2023 11/30/2023.

23. Hispanic, black and pacific islander perspectives on COVID-19 outreach strategies and patient centered outcomes (HEAR US) (research). Co-PI: Seto T. Funded by FDA; $969,000 awarded on 4/1/2022; project period 4/1/2022 - 3/31/2024.

24. Integrative Center for Precision Nutrition and Human Health (research). Other: Rettenmeier C, Stenger VA. PI: Berry. Funded by NIH; $7,500,000 awarded on 12/01/2021; project period 12/01/2021 - 11/30/2026.

25. John & Violet Kay Summer Research Fellowship. Other: Chow D. Funded by Iolani High School Student Summer Fellowship program; $2,000 awarded on 6/1/2021; project period 6/1/2021 - 8/21/2023.

26. Kinā’ōle: Expanding Telestroke Coverage to the Prehospital Setting in Hawaii’s Rural Communities HRSA Telemedicine Network Grant Program (TNGP). PI: Koenig M. Funded by HRSA; $1,200,000 awarded; project period 2019 - 2023.

27. Kuakini Reimbursement Agreement (non-research). PI: Kuwada S. $137,636 awarded on 7/29/2022; project period 7/1/2022 6/30/2023.

28. Lesion Composition and Quantitative Imaging Analysis on Breast Cancer Diagnosis (research). Other: Seto T. Funded by NIH; $79,000 awarded on 8/9/2021; project period 8/9/2021 - 7/31/2026.

29. Longitudinal Study of Early NAFLD Progression and the Gut Microbiome in Asian Americans, Native Hawaiians and Whites (research). Other: Rettenmeier C. Funded by NIH; $3,342,000 awarded on 9/26/2022; project period 9/26/2022 - 6/30/2027.

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30. Monocytes and macrophages in HIV cardiovascular risk (research). PI: Boisvert W. Funded by NIH. Project period 2017 - 2023.

31. Mouse Model of SARSCoV2 (research). PI: Seidel Tallquist M. Funded locally; $50,000 awarded on 12/1/2020; project period 12/1/2020 - 6/30/2023.

32. Ola Hawaii Post Covid Pulmonary Long Covid Study (research). Other: Yess J. Funded by NIH; awarded on 9/1/2022; project period 9/1/2022 - 9/1/2024.

33. Ola HAWAII Team-Science Pilot Projects Program Native Hawaiian Experiences and Perceptions of Primary Care at Queen Emma Clinic. PI: Yess, J. 34. Pacific Basin Telehealth Resource Center (PBTRC) Contributor – UH Telecommunications and Social Informatics (TASI). Other: Berg, B. PI: Okamura, N. 2022.

35. Pacific Simulators (PACSIM) Contributor (HRSA). Other: Berg, B. PI: Withey, K. Project period 2021 - 2022.

36. Perceptions of Genomic Medicine and Technology among Native Hawaiian Patients Enrolled in a Longitudinal Healthcare Engagement Program (research). PI: Brown, S. Other: Yess, J. Funded by Hawaii Community Foundation (HCF) Medical Research; $60,000 awarded on 6/20/2022; project period 10/1/2022 - 3/30/2024.

37. Pacific AIDS Education and Training Center (PAETC)-Hawaii and US-Affiliated Pacific Islands (HRSA). Co-PI: Gangcuangco L. Funded by HRSA; $186,338 awarded on 9/26/2023; project period 7/1/2023 - 6/30/2024.

38. Phase II study of TSR-022 in combination with TSR-042 for the treatment of advanced hepatocellular carcinoma (research). PI: Acoba JD. Funded by GlaxoSmithKline plc (GSK); $533,966 awarded on 4/9/2018; project period 4/9/2018 - 4/9/2025.

39. Radial Echo Volumar Imaging Grant (research). PI: Stenger, VA. Other: Rettenmeier C. Funded by NIH; $900,000 awarded on 7/9/2020; project period 07/15/2020 - 03/31/2024.

40. Regulation of Metabolism by PKM2 in the Mouse Heart (non-research). PI: Shohet R. Funded by AHA; $137,636 awarded on 7/29/2022; project period 7/1/2022 - 6/30/2023.

41. Role of Anti-Idiotype Autoantibodies (AA) Directed Against ACE2 in the Development of Pulmonary Post-Acute Sequelae of SARSCoV2 Infection (PASC) (research). PI: Shikuma C. Funded by Leahi Foundation (HCF) $60,000 awarded on 7/26/2023; project period 12/1/2022 - 6/1/2024.

42. Role of Fibroblasts in Cardiovascular Inflammation (research). PI: Seidel Tallquist, M. Funded by NIH; $275,000 awarded on 8/18/20218; project period 2/1/2021 - 1/31/2023.

43. Role of Lipofibroblast in Alveolar Development (research). PI: Seidel Tallquist, M. Funded by NIH; $2,000,000 awarded on 2/1/2021; project period 08/18/2018 - 06/30/2023.

44. Role of Monocyte/Macrophage in HIV-related Cardiovascular Risk (research). PI: Chow, D. Funded by NIH; $1,200,000 awarded on 9/1/2018; project period 9/1/2018 - 8/30/2022.

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45. Queen Emma Land Company (QELC) Reimbursement Agreement (non-research). PI: Kuwada, S. $613,439 awarded on 8/26/2022.

7/1/2022 - 6/30/2023.

46. Queen’s Medical Center (QMC) Reimbursement Agreement (non-research). PI: Kuwada, S. $47,112 awarded on 8/2/2022. 7/1/2022 - 6/30/2023.

47. Ryan White Part B Care Act grants (HRSA). PI: Chow, D. Co-PI: Gangcuangco, L. Other: Lu D, Shikuma C, Shiramizu, B. $300,000 awarded on 1/1/2021; project period 1/1/2023 - 12/31/2023.

48. Training in Cardiovascular Research at the University of Hawaii (HRSA). PI: Shohet, R. Other: Seidel Tallquist, M. Funded by NIH; $500,000 awarded on 8/1/2018; project period 8/1/2018 - 7/31/2023.

49. Transformational Project Award - Lipid metabolism in the endothelium (research). PI: Boisvert, W. Funded by AHA. Project period 2020 - 2023.

50. Ultrasound-directed gene therapy for Hemophilia B (research). PI: Shohet, R. Funded by Chun Foundation; $24,000 awarded on 6/1/2023; project period 7/1/2023 - 6/30/2024.

51. University of Hawai’i Cancer Center Seed Grant (research). PI: Kuwada, S. Funded by UH; $17,000 awarded on 4/1/2022; project period 4/1/2022 - 6/30/2023.

52. Unpacking the Mechanisms of Disparities for HIV-Related Hypertension in African American and Asian Pacific American Men who have Sex with Men (MSM) Study (research). Co-PI: Chow, D. Funded by NIH; $2,100,00 awarded on 9/1/2018; project period 9/1/2018 8/30/2022.

53. QI and Population Health Initiatives - Native Hawaiian Population. Other: Yess, J.

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MAHALO TO OUR DONORS We are deeply grateful for the support received over the past year via the Department of Medicine Enhancement Fund, the Elizabeth Tam Memorial Fund, and other University of Hawai’i Foundation Accounts. Private, often anonymous donations have helped us to fulfill our departmental mission in multiple ways, including: Faculty development Research endeavors Neighbor island outreach Resident and medical student academic development Staff professional development Clinical Faculty recognition Visiting professorships To donate or learn more about our work, please contact Executive Director of Development, Julie Inouye at (808) 692-0873 or Julie.Inouye@uhfoundation.org