2015 U-M Kellogg Eye Center Annual Report

UNIVERSITY OF MICHIGAN W.K. KELLOGG EYE CENTER 2015 ANNUAL REPORT

30

th Anniversary

~ Our Purpose ~ To improve lives through curing, preventing, and treating eye disease

TEAMWORK INTEGRITY INNOVATION CARING

Eye on the Future University of Michigan Kellogg Eye Center Annual Report 2015

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7

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21

Kellogg Celebrates 30th

Advances in Education and

Anniversary

Patient Care

4

15 Kellogg Faculty Develop Digital

Learning Tools

Event at the U-M Museum of Art Marks Milestone

6 Establishing the Qais A.

Farjo, M.D., Memorial Lectureship

16 Residents Push Forward

Innovations and Research

22

Global Initiatives 22 Kellogg Hosts Third Annual

International Night 24 Helping an Ethiopian Hospital

Establish an Ophthalmology

Residency Program

18 Eye Care Goes Back to School

Vision Restoration and Research 7

Kellogg Hosts First Meeting of Argus II® Retinal Prosthesis System Investigators

9

Kellogg Scientists Brief Congress on Vision Research

10 New Clinical Research Center

Offers More Trials 12 Kellogg Partners with U-M

Biointerfaces Institute to

Accelerate Therapeutic Advances

19 Eye Clinic Expands at the VA

For patient appointments, please call 734.763.8122.

Philanthropy in Support

Clinic phone numbers are online under “Patient Care” at www.kellogg.umich.edu

of Research 20 Kellogg Receives $3.5M Gift

from the Jerome Jacobson Foundation 21 Updates on Glaucoma

Research at Kellogg

Front cover: David Antonetti, Ph.D.; Elizabeth Du, M.D.; an image of the Kellogg Eye Center; Denise John, M.D.; Tyson Kim, M.D., Ph.D.; an image of a 3D embryonic stem cell culture from the lab of Robin Ali, Ph.D.; and Courtney Dewey, O.D. *This report covers the time period of July 1, 2014 through September 30, 2015.

Front row: Raymond Douglas, M.D., Ph.D., Shahzad Mian, M.D., and Denise John, M.D. Back row: Alan Sugar, M.D., Michael Smith-Wheelock, M.D., Thomas Gardner, M.D., M.S., and Paul Lee, M.D., J.D.

The Chair’s Perspective Dear Friends,

scientists are pursuing in collaboration with colleagues from around the University. For example, among our new initiatives

This past fall, the University of Michigan Department of

Ophthalmology and Visual Sciences, founded in 1872, celebrat-

Institute. This collaboration has taken shape with three projects

ed the 30th anniversary of the W.K. Kellogg Eye Center. The

aimed at exploring novel methods of diagnosing types of ocular

construction of the Kellogg Tower in 1985 enabled our depart-

tumors and new treatments for diabetic retinopathy and macular

ment to unify offices, laboratories and clinical spaces that were

degeneration.

scattered across seven medical campus buildings. The opening

of the Brehm Tower in 2010 provided room for expansion and

opened in June 2015, provides dedicated space at Kellogg for

the opportunity to work more closely with leading diabetes

our investigators to conduct clinical research in all areas of

researchers. These tremendous facilities have enabled our fac-

ophthalmology. The KCRC team works with our faculty and

ulty, staff and trainees to work more effectively at shaping the

our volunteer patients to move clinical trials forward with the

future of vision science and eye care. Within these buildings, it

goal of evaluating the effectiveness of new treatments. Some of

is the teamwork and ingenuity of our people that have been the

our current trials involve assessing innovative therapies for age-

hallmarks of research, education and patient care at Kellogg.

related macular degeneration, investigating novel approaches

to treating cancer around the eye and examining a new therapy

In this year’s Annual Report, you will have the opportunity

to learn about some of the new ideas in research that Kellogg 2

is a joint project with investigators at the U-M Biointerfaces

The new Kellogg Clinical Trials Center (KCRC), which

for the treatment of dry eye disease.

At Kellogg, we realize that sharing information and

Introduction to Cataract Surgery for residents and trainees

experience means a faster path to improvement. As you may

who will perform cataract surgery. The course, which is free

recall from last year’s Annual Report, Kellogg retinal surgeons

of charge and offered globally, has run twice with 545 people

performed the first four Argus II Retinal Prosthesis System

in 131 different countries completing the instruction.

(Argus II) implantations in the United States since FDA approv-

al. To improve the Argus II patient experience, Kellogg hosted

this year was Devon Ghodasra, M.D., vitreo-retinal surgery

the first meeting of Argus II Investigators. Over 50 retinal sur-

fellow, who was awarded the Raymond R. Margherio Award

geons, researchers and rehabilitation professionals from around

for his research on vitreous cytokines. In addition, Thomas

the world who have worked with the implant, met to discuss

W. Gardner, M.D., M.S., Professor, was awarded the Retina

and share approaches, surgical and rehabilitation techniques

Society Award of Merit in Retina Research honoring Charles

®

Among those at Kellogg honored for their achievements

and outcomes. Five additional implantations have since been performed at Kellogg. Worldwide, the Argus II has now been implanted in over 130 patients in 29 centers in the United States, Europe and the Middle East.

Expanding a commitment to global

initiatives, two of our faculty members served as advisors in establishing a stateof-the-art residency training program for ophthalmologists at the St. Paul Hospital Millennium Medical College in Addis Ababa, Ethiopia. The program, one of only four in the country, began training

L. Schepens, which recognizes outstand-

“Together, we are partners in solving eye disease and are excited and eager to accomplish even more in

”

the coming years.

ing national achievement in retina research.

Mark W. Johnson, M.D., Professor and head of Kellogg’s Retina and Uveitis Service, was elected to serve as the new president of the Retina Society.

From developing new treatments and educational innovations to cultivating leaders in the field, the people of Kellogg have done and continue to do much to advance the visual sciences and the care of our patients.

In 2015, Kellogg had more than 163,000 patient visits and performed more than

—Paul P. Lee, M.D., J.D.

7,600 surgical procedures. As our patient

its first six residents last year. We are

volumes grow, we are more motivated than

excited to work with our Ethiopian colleagues to develop the

ever to achieve our goal of improving lives through curing,

program and an eye care center that will become a regional

preventing, and treating eye disease.

center of excellence. We also welcomed Thomas Lietman, M.D.,

Director of the F. I. Proctor Foundation, as our Center for

research and successes. You helped make the achievements

International Ophthalmology’s third Scholar-in-Residence,

of the last year and the last 30 years possible. Together, we

benefiting from his expertise in trachoma and other ocular

are partners in solving eye disease and are excited and eager

infectious diseases throughout the world.

to accomplish even more in the coming years.

We want to thank all who have contributed to our growth,

Two of our faculty members have developed innovative

ways to make information and training more accessible.

Jonathan Trobe, M.D., Professor, authored The Eyes Have It, an educational app for iOS and Android, cataloging 134 eye

Paul P. Lee, M.D., J.D.

conditions, 410 images, more than 40 narrated animations and

F. Bruce Fralick Professor and

patient videos, six screening examination videos and an eye

Chair, Ophthalmology and Visual Sciences

anatomy review. Assistant Professor Elizabeth Du, M.D., has

Director, W.K. Kellogg Eye Center

developed a comprehensive four-week Coursera online class

30 Years of Service Growing to better serve our patients and expanding our research to find new treatments to cure blinding eye diseases.

PATIENT VISITS

1985 2015 36,852

163,232

SURGERIES

1,825 7,681

FACULTY

15 96

RESEARCH FUNDING

$0.9M

$14M 3

Mr. and Mrs. Dan Kachnowski share a toast.

Jerry May, Vice President of the U-M Office of Development, chats with Thomas Varbedian, M.D.

Mr. and Mrs. John Breen, Jerome Jacobson Foundation.

KELLOGG CELEBRATES 30TH ANNIVERSARY Marking an Important Milestone in our Eye Center’s Growth and History

Mr. and Mrs. John R. Breen announced a $3.5M gift from

the Jerome Jacobson Foundation. “Jerome’s friends often heard how Dr. Lichter, his longtime physician, assured him that with proper management of his condition—through medication

Last fall, Kellogg celebrated its 30th anniversary with an event

and surgeries when necessary—he would have sight on the last

at the University of Michigan Museum of Art. Among our

day of his life. And he did,” says Mr. Breen, co-trustee of the

many honored guests were Paul A. Sieving, M.D., Ph.D., former

Foundation.

faculty member and founder of Kellogg’s Center for Retinal and

Macular Degeneration and current Director of the National Eye

Swaroop, Ph.D., former Kellogg faculty member and current

Institute at the National Institutes of Health; and Linh Nguyen,

Chief of the Neurobiology-Neurodegeneration and Repair

chief operating officer of the W.K. Kellogg Foundation.

Laboratory at the National Eye Institute, returned to give

the inaugural address of the Qais A. Farjo, M.D., Memorial

Paul R. Lichter, M.D., M.S., Founding Director of the

W.K. Kellogg Eye Center and former Chair of the Department

Earlier in the day, at Kellogg’s Fall Reunion, Anand

Lectureship.

of Ophthalmology and Visual Sciences for 34 years, highlighted the remarkable growth and change during the last three decades.

For more information about these gifts, see pages 6 and 20.

Aisha Faridi, Amjad Ahmad, M.D., John Arendshorst, M.D., Linda Katz, M.D., and Douglas Katz, M.D., at the 30th anniversary event.

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Paul Lichter, M.D., M.S., Paul Lee, M.D., J.D., and Linh Nguyen, COO, W.K. Kellogg Foundation.

Paul R. Lichter, M.D., M.S., at the podium.

“Our vision was for Kellogg to become one of the finest eye centers in the nation and that has been realized.

We now have the facilities and, more importantly, the people to shape the

”

future of eye care and vision science.

— Paul R. Lichter, M.D., M.S. James Woolliscroft, M.D., former Dean of the U-M Medical School, shares a moment with Michael Staebler, J.D.

30th Anniversary celebration at the University of Michigan Museum of Art. 5

Kellogg faculty and alumni gather at Fall Reunion Day to celebrate the introduction of the first Qais A. Farjo, M.D., Memorial Lecture.

THE QAIS A. FARJO, M.D., MEMORIAL LECTURESHIP A Fitting Tribute to One of Our Department’s Most Beloved Alumni

Anand Swaroop, Ph.D., and Paul A. Sieving, M.D., Ph.D., join in the celebration.

Anastas Farjo, M.D., Anand Swaroop, Ph.D., Muno Farjo, M.D., Rand Farjo, M.D., Deena Farjo, Rafid Farjo and Reem Farjo.

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The Qais A. Farjo, M.D., Memorial Lectureship was created through the generosity of those who were touched by Dr. Farjo’s life and highlights his broad expertise in research, clinical care and education. The lectureship will enable the Department to host speakers who will share advances in their specialties, from translational research to collaborative care, to innovative surgical techniques.

A remarkable physician, surgeon, researcher and mentor, Dr. Farjo completed his medical degree, residency and fellowship at the University of Michigan before joining the faculty of the Department of Ophthalmology and Visual Sciences.

Dr. Farjo is known for his contributions to basic research through his characterization of the NRL gene, now known as a master transcription factor governing photoreceptor cell fate during development. He also served as medical director of the Michigan Eye-Bank. Dr. Farjo died in February 2014 after fighting a courageous battle against cancer.

The inaugural address was given by Anand Swaroop, Ph.D., former faculty member and Chief of the NeurobiologyNeurodegeneration and Repair Laboratory at the National Eye Institute, during the 21st Annual Fall Reunion Day.

Kellogg hosts the first worldwide meeting of Argus II investigators.

WORLDWIDE NETWORK OF ARGUS II® INVESTIGATORS JOIN FORCES Collective Experience Draws Specialists from Top Tier Institutions Around the World

challenges and reflect on what we’ve learned,” says K. Thiran Jayasundera, M.D., Assistant Professor. “The need for open communication is central—not just between different segments of people in one institution, but across institutions—so that

In 2014, Kellogg retinal surgeons performed the first four

as a group we can refine this process that will ultimately benefit

Argus II Retinal Prosthesis System (Argus II) implantations

our patients.”

in the United States of an artificial retinal sensing device, or

“bionic eye,” which was approved in 2013 by the U.S. Food

favorable results, as well as new challenges. The event focused

®

and Drug Administration. Five additional

Initial experiences with the Argus II implant have delivered on four areas of optimization—patient

implantations have since been performed at

“This was a significant event, the first

Kellogg. The device is intended for patients

of its kind, marking a critical juncture

rehabilitation and surgical technique.

blinding eye disease. Worldwide, Argus II has

for all of us to share experiences,

of an Argus II treatment, which starts with

now been implanted in over 130 patients in

highlight challenges and reflect on

screening patients to find the right fit to

the Middle East.

what we’ve learned.”

tations and the correct motivations,” says

— K. Thiran Jayasundera, M.D.

with retinitis pigmentosa, a degenerative and

29 centers in the United States, Europe and In 2015, Kellogg hosted the first meeting

of Argus II Investigators, providing an oppor-

selection, device programming, visual “The meeting covered the entire process

ensure that each patient has realistic expecByron L. Lam, M.D., Professor and Robert Z. & Nancy J. Green Chair in Ophthalmol-

tunity for over 50 retinal surgeons, researchers and rehabilita-

ogy at the Bascom Palmer Eye Institute. “There were produc-

tion professionals to sit together in one room to discuss surgical

tive technical discussions particularly about how to make the

techniques and outcomes.

implantation more successful and how to avoid some of the

adverse events that can occur.”

“This was a significant event, the first of its kind, marking

a critical juncture for all of us to share experiences, highlight

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Robert J. Greenberg, M.D., Ph.D., Chairman of Second

Optimizing visual rehabilitation

Sight Medical Products, the device manufacturer, noted that the

In visual rehabilitation, therapists help patients learn how to

meeting marks an important milestone. “This is the first time

interpret the new kinds of visual signals they perceive and then

that a critical mass from around the world is together sharing

incorporate them into daily activities. “To use the device to its

their great experiences with the technology,” says Dr. Greenberg.

fullest, patients must complete a two-pronged rehabilitation

“There is a real sense of excitement.”

program: in-clinic rehabilitation with an occupational or low

vision therapist and community rehabilitation with an orien-

Moving forward, Dr. Greenberg expects that the external

system for the next generation Argus II will be available in some

tation and mobility specialist,” says occupational therapist

markets worldwide beginning in late 2016.

Ashley Howson, M.S., OTR/L. “As part of the rehabilitation process, therapists provide training and guided practice to help

Selecting the right patient

the patient learn how to use the device to increase independence

Genetic counselor and Assistant Research Scientist Kari E.

and quality of life with meaningful activities such as identifying

Branham, M.S., CGC, works with patients during the screening

where a loved one is standing, sorting laundry or detecting lines

process to see if they are candidates for the Argus II implant.

in a crosswalk.”

“A great deal of effort must be put into the patient selection process. The process from pre-op to rehabilitation is rigorous with the requirement of a series of visits,” says Ms. Branham.

“Completing a comprehensive evaluation by an occupational therapist before surgery helps identify learning styles, cognitive and physical impairments, psychological concerns, and to continue conversations with patients about setting reasonable goals, managing expectations and staying motivated throughout the long rehabilitation process.”

Fine tuning the device programming Electrophysiologist and Assistant Professor Naheed W. Khan, Ph.D., assesses outcomes and works with device programming at Kellogg. “If the patient is to perceive visual signals, the device must be programmed correctly and adjusted over time,” says Dr. Khan. “Device programming requires two to three sessions, which can be arduous for the patient, but this step can determine the quality of visual performance and whether the patient can use the device successfully.”

Evaluating surgical outcomes Along with selecting the right patient, fine tuning the device and optimizing visual rehabilitation, Dr. Jayasundera reflected on some of the surgical variables that could improve patient outcomes. “Based on a very small sample size, it appears that younger patients may have better visual function after surgery, possibly due to a healthier residual inner retina,” he explains.

“We also concluded that we may not need to exclude patients with staphyloma, an abnormal protrusion of the uveal tissue via a weakness in the eyeball, but rather should adapt our surgical technique. Moreover, there is a need to develop surgical strategies to avoid hypotony, an intraocular pressure of 5 mm Hg or less, and conjunctival erosion.”

Proposed modifications to the device include new glasses

and a vector processing unit with increased comfort, longer battery life, improved ease of use, custom camera, improved telemetry, faster processing and new filters.

THE ARGUS USERS' SUPPORT GROUP In 2015, the Kellogg Argus II team hosted the First Argus II® Retinal Prosthesis System Users' Support Group. The meeting provided a platform for our Argus II users to share their experiences with the device with one another, the Kellogg Argus II team, and engineers at Second Sight, the device manufacturer.

Donna Chapman, Linda Schulte and Mary Hawkins at the first Argus II® Retinal Prosthesis System Users' Support Group held at Kellogg.

KELLOGG SCIENTISTS SELECTED

BY THE NATIONAL ALLIANCE FOR EYE AND VISION RESEARCH TO BRIEF CONGRESS

Rajesh Rao, M.D., (left) and Jason Miller, M.D., Ph.D., update members of the United States Congress.

Rajesh C. Rao, M.D., Assistant Professor, and postdoctoral

says Dr. Rao. “From gene therapy to stem cells to preci-

fellow and incoming resident Jason Matthew-Lewis Miller,

sion medicine, we have never been at a more promising time

M.D., Ph.D., were among 22 scientists selected to update

in translating cutting-edge technologies to patient care for

members of the U.S. Congress on ophthalmic science last fall

diseases such as age-related macular degeneration, diabetic

by the National Alliance for Eye and

retinopathy, inherited retinal degenerations

Vision Research (NAEVR) Emerging

“I am honored to represent young vision

Vision Scientists Program, a coalition of

scientists at Kellogg and across the coun-

55 professional, consumer and industry

and eye cancers.”

Dr. Rao explains that there remains a great deal of work to do. “As the largest supporters

organizations involved in eye care. Drs.

try in our collective goal to highlight the

of vision research, our lawmakers, through the

Rao and Miller presented summaries

importance of vision research in finding

National Eye Institute, Departments of Defense

attended a House hearing on vision

new treatments and cures for blindness

the most important role in finding new cures

research and met with U.S. representa-

to our nation’s lawmakers.”

for blindness,” says Dr. Rao. “We want to assist

—Rajesh C. Rao, M.D.

loss from blinding eye diseases will worsen as

of their research to Congressional staff,

tives and senators to lobby for expanded funding for the National Eye Institute.

“I am honored to represent young

and Veterans Affairs, and other agencies, play

them in budgeting for the future, since vision our population ages. I hope that our advocacy

vision scientists at Kellogg and across the country in our collec-

will play a part in ensuring our nation’s future needs for our

tive goal to highlight the importance of vision research in finding

most valued sense—vision—which allows us to read, walk,

new treatments and cures for blindness to our nation’s lawmakers,”

drive, work, recognize faces and care for others.”

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Grant Comer, M.D., M.S., examines Gwendolyn Rosier, a patient in his trial on treatments for proliferative diabetic retinopathy, in the new Kellogg Clinical Research Center.

NEW CLINICAL TRIALS CENTER OPENS THE DOOR FOR MORE STUDIES In an effort to offer more clinical trials to patients, the Eye

The following stories highlight a few of our current trials.

Center recently opened its Kellogg Clinical Research Center

For a full list, visit: www.kellogg.umich.edu/research/open_

(KCRC)— 5,100-square-feet of dedicated space for investiga-

clinicaltrials.html

tors who conduct clinical research with resources to support patient-oriented research studies in the specialties of retina, cornea, glaucoma and pediatrics. Ocular oncology, oculoplastics and telemedicine projects are also included. Having

KELLOGG EXPLORES INVESTIGATIVE NEW TREATMENT FOR WET MACULAR DEGENERATION

dedicated space for clinical trials frees the ophthalmology

Wet age-related macular de-

clinics from the complicated process of registering and

generation (AMD) is caused

examining clinical trial patients.

by the growth of abnormal

Grant M. Comer, M.D., M.S., Assistant Professor, leads

blood vessels beneath the

the eight-person KCRC team, who work with Kellogg faculty

macula, the part of the retina

and volunteer patients to move clinical trials forward with

that provides detailed, central

the goal of finding new treatments of high impact.

vision. These blood vessels

“We have seen tremendous progress in our ability to

are fragile and tend to hemor-

operate a wider range of clinical trials over the past year,” says

rhage or leak fluid, resulting

Dr. Comer. “From the addition of personnel with expertise in clinical trial operations to the opening of the research space in June, the KCRC, faculty scientists and our research volunteers are already exploring the next generation of treatment options available to our patients.”

Our current trials include a study to improve the treatment

of wet age-related macular degeneration, the investigation of a new drug to treat cancer around the eye and the examination of a supplement to treat dry eye disease.

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in the formation of scar tissue that can lead to permanent vision loss. Currently, the best treatment for wet AMD is injections of vascular endothelial growth factor (VEGF) inhibitors, which have been shown to improve vision rather than simply slowing the rate of vision loss. For patients to reap the benefits of these injections, however, they usually have to be done repeatedly.

Grant M. Comer, M.D., M.S., Assistant Professor, is

exploring a potential new treatment—encapsulated cell therapy

of the trial is to test whether this new drug will lead to improved

or ECT—that he hopes will replace these injections. The NT-

ophthalmic outcomes in patients suffering from BCCA around

503 ECT implant, about the size of a grain of rice, is surgically

the eye and to identify markers for tumor response.

placed into the eye under local anesthesia and contains tiny

capsules of cells that continuously release VEGF inhibitors to

the eye and can be disfiguring and blinding,” says Dr. Kahana.

the back of the eye to treat wet AMD.

“A clinical trial is needed to study how this innovative new drug

can be used to treat this cancer while preserving visual function.

Through this randomized study, Dr. Comer and his team

“Advanced basal cell carcinoma is commonly found around

will compare treatment with the NT-503 ECT implant to the

Given how common basal cell carcinoma is, and its potential

routine injections patients receive for wet AMD. “Clinicians

impact on vision, I’m pleased that such an important trial will

have been searching for ways to reduce the frequency of

be based at Kellogg and at U-M.”

injections into the back of the eye that are often required for

wet AMD,” says Dr. Comer. “This clinical trial will allow us

Kellogg plans to enter 50 patients over four years. Participation

to explore the safety and effectiveness of this new way of

in the study is for one year after initiation of the drug treatment.

delivering these medications.”

For more information, contact clinical research coordinator

Sonal Trivedi, M.S., CCRP, at strivedi@med.umich.edu.

The study is currently enrolling patients with the goal of

Enrollment for this trial is open to patients with BCCA and

six at Kellogg and 90 worldwide. Participation in this study is for two years. Eligible patients must have active, wet AMD

KELLOGG EXPLORES SUPPLEMENTS AS TREATMENT

and have had a good response to previous injections of a VEGF

FOR DRY EYE

inhibitor drug (Avastin, Lucentis or Eylea). Kellogg is one of

Cornea specialist Roni M.

approximately 36 international sites participating in this study,

Shtein, M.D., M.S., Associ-

which is sponsored by Neurotech Pharmaceuticals, Inc. For

ate Professor, is leading the

more information, contact clinical research coordinator Pamela Campbell, COT, CCRP, at pamtitus@med.umich.edu.

Kellogg site of the Dry Eye

KELLOGG INVESTIGATES NEW DRUG TO TREAT

or DREAM, trial in hopes

Assessment and Management, of finding a new treatment

CANCER AROUND THE EYE

option for a condition that Vismodegib is a new drug

can cause severe ocular

recently approved by the

pain, corneal scars and ulcers,

U.S. Food and Drug Admin-

and loss of vision.

istration for treatment of

The DREAM study evaluates the safety and effectiveness

advanced or aggressive basal

of omega-3 fatty acid supplements to treat the symptoms of

cell carcinoma (BCCA), the

moderate to severe dry eye disease. These over-the-counter

most common type of eye

nutritional supplements are currently used to treat high levels

cancer, affecting approxi-

of fat in the blood.

mately 750,000 people in the

United States every year.

patients to seek care from their eye care professionals,” says

Oculoplastic surgeon Alon Kahana, M.D., Ph.D., Associ-

“Dry eye disease is extremely common and leads many

Dr. Shtein. “The DREAM study is the first major trial on dry

ate Professor, is leading a research team that aims to determine

eye disease that is not funded by a pharmaceutical company.

whether vismodegib can be used to preserve vital tissues around

We are excited to be a part of it.”

the eye as well as visual function in patients with BCCA. The

team also will perform basic and translational research on the

may extend their participation for an additional year. Dr. Shtein

response of cancer tissue to the drug. The clinical trial, termed

and her team hope to enroll 50 patients here at Kellogg, with a

VISORB (for VISmodegib for ORbital and periocular Basal cell

national goal of 600 patients. The trial is led by the University

carcinoma), was awarded a competitive research grant from

of Pennsylvania and funded by the National Eye Institute, a

Genentech, Inc., the manufacturer of vismodegib, which also

branch of the National Institutes of Health.

will provide the drug for the trial. Additional funding was

obtained from the U-M Head and Neck Oncology Program,

tor Munira Hussain, M.S., COA, CCRP, at hussain@med.

Kellogg and the U-M Comprehensive Cancer Center. The goal

umich.edu.

Participation in the study is for one year. Eligible patients

For more information, contact clinical research coordina-

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KELLOGG SCIENTISTS JOIN FORCES WITH U-M BIOINTERFACES INSTITUTE Collaboration Sparks Opportunities to Accelerate Bench to Bedside Discoveries

Kellogg scientists partnered with the U-M Biointerfaces

Institute, a group of interdisciplinary biomedical researchers, at a recent two-day conference to address barriers to solving thera-

Hakan Demirci, M.D., David Antonetti, Ph.D., and Rajesh Rao, M.D.

peutic challenges for patients with blinding eye diseases. The B-EYE Biointerfaces Institute/Ophthalmology Challenge, a joint initiative focused on how interactions in the life sciences, physi-

Dr. Antonetti will collaborate with Steven P. Schwendeman,

cal sciences and engineering can accelerate the development of

Ph.D., the Ara G. Paul Professor and Chair of the U-M Depart-

new drug delivery systems, was inaugurated at this conference.

ment of Pharmaceutical Sciences, to develop drug delivery de-

Belinda Seto, Ph.D., Deputy Director of the National Eye

vices for novel drugs that target vessel permeability in the retina,

Institute, delivered the keynote address Vision Breakthroughs

a problem in many leading vision-threatening diseases, including diabetic retinopathy and age-related macular

Enabled by Multidisciplinary Approaches. The

“Collaborations with groups such

degeneration.

followed by breakout sessions where attendees

as the U-M Biointerfaces Institute

translate our findings into better therapies for

brainstormed ideas and concepts, identified

can provide important avenues that

our patients. Collaborations with groups such

orative research and seed fund proposals in the

allow us to turn our discoveries into

important avenues that allow us to turn our

categories of biomaterials and drug delivery,

novel treatments for eye diseases.”

discoveries into novel treatments for eye diseas-

—David A. Antonetti, Ph.D.

identified important signaling pathways and

event also included presentations by specialists in ophthalmology and biomedical sciences,

challenges, and designed next steps for collab-

microfluidics and sensors, cell and tissue engineering, and nanotechnology.

“One of our major goals at Kellogg is to

as the U-M Biointerfaces Institute can provide

es,” says Dr. Antonetti. “For example, we’ve are developing inhibitors to control these path-

Three Kellogg faculty members were awarded B-EYE grants

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ways. Interactions with faculty like Dr. Schwendeman will allow us to develop the best ways to deliver these drugs to patients.”

Rajesh C. Rao, M.D., Assistant Professor, received a chal-

Hakan Demirci, M.D., Associate Professor and Director of

lenge grant for his proposal Direct Reprogramming of Fibro-

Ocular Oncology, was the recipient of a challenge grant for

blasts into Photoreceptors by Defined Factors: A Novel Thera-

his proposal In-vivo Biopsy of Intraocular Tumors by Physio-

peutic Approach for Dry Age-Related Macular Degeneration,

chemical Photoacoustics. Dr. Demirci’s work seeks to aid in the

A Common and Untreatable Cause of Blindness. Dr. Rao will

differential diagnosis of intraocular tumors such as choroidal

work with Kellogg postdoctoral fellow Qiang Li, M.D., Ph.D.;

melanomas, hemangiomas and metastases. He is collaborating

U-M Department of Pathology research investigator Luis Villa

with U-M Department of Radiology research investigator

Diaz, Ph.D.; and Paul H. Krebsbach, D.D.S., Ph.D., the Roy H.

Guan Xu, Ph.D., to develop an ocular imaging system, called

Roberts Professor of Dentistry, Professor of Biomedical Engi-

photoacoustic imaging, a non-invasive, low cost imaging

neering, and Chair of the Department of Biologic and Materials

technology for structural and functional imaging.

Sciences and Division of Prosthodontics at the U-M School of

Dentistry. Dr. Rao will work with Dr. Krebsbach to reprogram

David A. Antonetti, Ph.D., Professor, was the co-recipient

of a challenge grant for his project Sustained Drug Delivery

skin cells to retinal cells without going through an intermediate

for Restoration of Blood Retinal Barrier in Macular Edema.

embryonic stem cell stage.

KELLOGG FACULTY AWARDED R01 GRANTS

David A. Antonetti, Ph.D., Pro-

fessor, has received the renewal of

in the RPE will identify additional ion channel genes that are

his NIH R01 grant Mechanisms

essential to keeping the photoreceptors healthy. “This research

of Retinal Vascular Permeability

is relevant as it will fill large gaps in our knowledge of how

in Diabetes. Dr. Antonetti studies

the healthy RPE works to sustain the photoreceptors and

the cellular mechanisms by which

may also shed new light on what causes retinal degeneration,”

endothelial cells, the cells that make

he says.

Dr. Hughes hopes that further research on ion channels

up blood vessels, proliferate and are altered during diabetic retinopathy and macular edema. Recent clinical trials have demonstrated that targeting vascular endothelial growth factor (VEGF) can effectively prevent progression of vision loss and, for some patients, restore visual acuity. However, not all patients respond to anti-VEGF therapies, which require repeated intraocular injections. Therefore, understanding how VEGF prevents vessel alterations is critical.

Dr. Antonetti also studies inflammatory factors that are

elevated in patients with diabetic retinopathy. Understanding the mechanisms underlying the effects of growth and inflammatory factors, as well as proteins such as occludin that are involved in vessel permeability, is expected to provide new insight into the nature of blood vessel growth and maturation. “My ultimate goal is to identify new targets for therapeutic intervention that are effective against growth factors and inflammatory cytokines,” says Dr. Antonetti.

Thomas W. Gardner, M.D., M.S.,

Professor, and Steven F. Abcouwer, Ph.D., Associate Professor, have

received the renewal of their NIH R01 grant Regulation of Retinal Cell Death in Diabetes. The ultimate goal of their research is to develop treatments that will prevent vision loss in persons with diabetes. This project focuses on how diabetes impacts the retinal neurons that provide vision. Recently developed anti-VEGF therapies can limit damage in many patients with advanced diabetic retinopathy. These treatments are employed late in the disease process, when blood vessels are affected, but do not address the earlier damage to the neurosensory retina caused

Bret A. Hughes, Ph.D., Professor,

has received the renewal of his NIH

by diabetes.

Drs. Gardner and Abcouwer

R01 grant Ion Conductances in the

are continuing their studies, which identify novel pathways that

Retinal Pigment Epithelium. Dr.

cause dysfunction and death of these neurons, in the hope that

Hughes’ overall goal is to under-

therapies intervening at earlier stages of diabetes will prevent

stand how ion channels in the cell

severe damage. The specific goals of this study are to define

membranes of the retinal pigment

the role of proteins called “mechanistic target of rapamycin

epithelium (RPE) operate to maintain

complexes” (mTORC) in retinal neuron function and survival,

the salt and water balance of the

and to define the ways in which diabetes affects these protein

photoreceptor environment. Muta-

complexes to cause diabetic retinopathy. “We hope that under-

tions in several genes that encode ion

standing the mechanisms underlying changes in these protein

channels expressed in the RPE have been found to cause retinal

complexes will enable development of therapies to prolong the

degeneration, underscoring the crucial role that these membrane

survival of retinal neurons and prevent the onset of sight-threat-

proteins play in maintaining retinal health and integrity.

ening diabetic retinopathy,” says Dr. Gardner.

13

Alon Kahana, M.D., Ph.D., Sayoko Moroi, M.D., Ph.D., and Joshua Stein, M.D., M.S., all moved their inventions forward by filing for patents in 2015.

PATENTS FILED FOR INVENTIONS BY KELLOGG FACULTY Automated Scalable Heat Shock Modification for Standard

Aquatic Housing Systems

the team of inventors developed a system that will display

Inventors: Alfonso Saera-Vila, Ph.D., Phillip E. Kish, Ph.D., and Alon Kahana, M.D., Ph.D.

Aquatic organisms are very useful for the experimental

study of human disorders. Changing the growth conditions of aquatic model organisms, including water temperature and pharmacologic exposure, is a very common research tool.

In order to improve the technology for changing tempera-

In order to better predict the outcome of MIGS procedures,

optical coherence tomography images that a surgeon can use to select anatomical features, biomarkers and other features of interest. The system can then translate the location of these features to an en face image and generate a map used for surgical planning.

Magnetoelastic Actuator for Glaucoma Drainage Devices

ture (i.e. “heat shock”) or drug delivery to aquatic colonies for

Inventors: Yogesh B. Gianchandani, Ph.D. (U-M College of

experimental and drug-screening purposes, Kellogg’s team of

Engineering), Venkatram Pepakayala, M.S.E. (U-M College of

inventors developed a parallel manifold system with continuous

Engineering), and Joshua D. Stein, M.D., M.S.

water flow that reduces labor and improves reproducibility of

treatment conditions.

from the anterior chamber to an external reservoir, where a fi-

Glaucoma drainage devices (GDDs) divert aqueous humor

brous capsule forms about 4-6 weeks after surgery and regulates Mapping of Internal Features on En Face Imagery

flow. GDDs have been successful in controlling intraocular pressure and preventing the worsening of glaucoma.

14

Inventors: Lawrence E. Kagemann, Jr., Ph.D., (University

of Pittsburgh), Joel S. Schuman, M.D., FACS (University

aqueous flow through the GDDs across the fibrous capsule

of Pittsburgh), and Sayoko E. Moroi, M.D., Ph.D.

around the end plate. To ease this resistance, the team invented

an enhancement to the GDDs using actuators with custom-

Minimally invasive glaucoma surgeries (MIGS) are a new

One issue with these devices has been the resistance to

classification of glaucoma procedures designed to lower the

ized geometries and 3D curvatures. These actuators, which are

pressure inside the eye. A major assumption of surgical success

remotely excited to resonance with a magnetic field generated by

is that abnormal resistance resides in the trabecular network

external coils, produce mechanical vibrations that can improve

and, once this resistance is bypassed, the outflow through

aqueous flow, prevent adhesion of scar tissue to the implant and

Schlemm’s canal and beyond is unimpeded. Outcomes, however,

facilitate removal of cells responsible for the development of

are not predictable and these procedures are performed with

dense fibrous tissues around the implant. By limiting scar tissue

no prior knowledge of the morphology of the patient’s aqueous

around the GDDs, the device can more effectively control the

humor outflow tract.

intraocular pressure.

KELLOGG BRINGS COURSERA ONLINE CLASS TO RESIDENTS WHO WILL PERFORM CATARACT SURGERY Introduction to Cataract Surgery

Elizabeth Du, M.D., has developed a Coursera online class for ophthalmologists.

is Offered Globally, Free of Charge Elizabeth Du, M.D., Assistant Professor, saw a need to make

learning the fundamentals of performing successful cataract

rated with Kellogg ophthalmologists from multiple specialties.

surgery more accessible to residents and trainees in the United

Comprised of weekly lectures by expert cataract surgeons, surgi-

States and worldwide.

cal video to demonstrate optimal performance of various steps,

weekly quizzes, and a pre-and-post-test, the course teaches the

To meet this need, Dr. Du developed a comprehensive

four-week Coursera online class Introduction to

To put together the comprehensive course, Dr. Du collabo-

fundamentals required to perform successful

Cataract Surgery. The course has run twice— in

“Each step, from preoperative

October 2014 and February 2015— with 545

evaluation to postoperative care,

extracapsular removal.

instruction and 2,610 people visiting the course

is covered to help prepare residents

ation to postoperative care, is covered to

site and watching at least a lecture.

and trainees for the operating

help prepare residents and trainees for the

the basics of cataract surgery on the Coursera

room, including intraocular lenses,

anesthesia, complications and challenging

platform for a number of reasons,” says Dr. Du.

anesthesia, complications and

cases,” says Dr. Du. “Since most cataract

and other trainees as they prepare to become

challenging cases.”

is imperative that the surgeon gain as much

cataract surgeons to have a comprehensive

—Elizabeth Du, M.D.

people in 131 different countries completing the

“We wanted to create a course to teach

“First, we thought it would benefit our residents

course delivered in a high-yield, high-impact

cataract surgery by phacoemulsification and “Each step, from preoperative evalu-

operating room, including intraocular lenses,

surgeries are done with the patient awake, it knowledge as possible prior to entering the operating room.”

fashion. Second, we wanted to see what the interest in this type

Coursera provides universal access to the world’s best

of course was globally and if it would be an effective tool to

education, partnering with top universities and organizations

help those in developing countries to have a more accessible

to offer courses online.

training resource.”

THE EYES HAVE IT: AN APP FOR iOS AND ANDROID A New Comprehensive Pocket Resource for Ophthalmic Information

Jonathan D. Trobe, M.D., Professor, saw the opportunity to provide greater resources to assist medical and optometric students in learning about ophthalmology. To address this need, Dr. Trobe authored The Eyes Have It, an app for iOS and Android comprising 134 eye conditions, 410 images, more than 40 narrated animations and patient videos, six screening examination videos and an eye anatomy review section.

“The text contains hyperlinks to supplemental images, narrated animations and videos that illustrate the clinical and teaching points. A picture-based, multiple-choice quiz allows users to assess their knowledge,” says Dr. Trobe. A well-known educator, Dr. Trobe is the author of The Physician’s Guide to Eye Care, now in its 4th edition.

15

First-year resident Tyson Kim, M.D., Ph.D., captures an image of a patient’s retina with his new CellScope Retina device.

RESIDENT PURSUES INNOVATION IN IMAGING With a background in physics and bioengineering, it is no

wonder that Tyson N. Kim, M.D., Ph.D., joined Kellogg’s

month before beginning his residency to screen diabetic patients

residency program with a promising project already in hand.

with the device. As he continues to gather data, he hopes to

“Kellogg was my top choice for residency because its support

prove that this technology can be used to screen for other blind-

for resident research and innovation is bar none,” says Dr. Kim.

ing eye diseases. Dr. Kim says that the next step is to collaborate

Upon starting his residency, Dr. Kim immediately benefitted

with physicians in the primary care setting to see if medical as-

from that support by enrolling in the House Staff Innovation

sistants can acquire images as high quality as those captured by

& Entrepreneurship Program. Designed for residents and

trained eye care professionals.

fellows at the University of Michigan and guided by experienced

instructors from across campus and in private industry, the

mary care physicians and other health care providers can use

34-week program provides participants with the tools and

to easily screen for several eye diseases,” says Dr. Kim. “This

resources needed to creatively address patient needs through

allows ophthalmologists to do fewer screenings while receiving

medical innovation.

far more referrals for disease treatment. Our hope is that health

care costs will be lowered, time saved and, most importantly,

Dr. Kim plans to continue work on the CellScope Retina

device born of a multi-institutional team including the lab-

To push the project forward, Dr. Kim came to Kellogg a

“We want to create a powerful, easy-to-use tool that pri-

that patients receive the vision care they need.”

oratory of Daniel A. Fletcher, Ph.D., at the University of California, Berkeley, and Todd P. Margolis, M.D., Ph.D.,

To learn more about the residency program at Kellogg,

and Jeremy Keenan, M.D., M.P.H., at the University of

visit: www.kellogg.umich.edu/education/residency.html

California, San Francisco. The device enables a smartphone to take high-quality, wide-field images of the retina by leveraging the high-resolution imaging, portability, computational power and wireless data transfer capability of smartphones.

According to Dr. Kim, the implications of this technol-

ogy are far-reaching. For example, he points out that diabetic retinopathy is one of the leading causes of preventable blindness in the world, and nearly half of diabetic patients in the United States fail to receive the recommended annual eye screening.

RANKED IN RESIDENCY PROGRAMS IN THE U.S.

#8

If more people can be screened by this device, more people can be treated to prevent or delay vision loss from this disease.

16

2015 SURVEY BY DOXIMITY/U.S. NEWS & WORLD REPORT

Kellogg Resident Develops Device to Make Eye Drops Easier to Use

First-year resident Lev Prasov, M.D., Ph.D., researches a new angle-closure glaucoma gene.

RESIDENT WINS BRIGHTFOCUS GRANT TO CONTINUE MEDICAL SCHOOL RESEARCH First-year resident Lev Prasov, M.D., Ph.D., chose Kellogg for his residency because of the broad support for research endeavors. Dr. Prasov, who earned a Ph.D. from the U-M Department of Human Genetics, will now be able to complete a research project he started during his fourth year of medical school with the help of a $100,000 grant from the BrightFocus Foundation. He will study a newly discovered angle-closure glaucoma gene.

The new gene, called MTRR, is involved in homocysteine metabolism. It was

discovered by studying a large family with iris cysts, which can block the fluid outflow channels in the eye, leading to an increase in eye pressure and glaucoma.

Collaborating with Ruma Banerjee, Ph.D., Professor and Associate Chair in the U-M Depart-

“I was drawn to this project

ment of Biological Chemistry, and Rima Rozen,

because it offered a look into a

Ph.D., Professor of Human Genetics and Pediatrics at McGill University in Montreal,

rare condition that has not been

Dr. Prasov will perform biochemical and

explored much in ophthalmology

functional studies on the protein that has been changed by the mutation. The team will also

literature.”

study the role of the normal protein in the eye

—Lev Prasov, M.D., Ph.D.

and screen for mutations in the gene in patients with the forms of glaucoma with which this biochemical pathway has been associated. Their findings will detail the role of the MTRR gene and its broader metabolic pathway in glaucoma and could lead to the development of future therapies.

“I was drawn to this project because it offered a look into a rare condition

that has not been explored much in ophthalmology literature,” says Dr. Prasov.

“More importantly, though, this project has given me the opportunity to work with a large family and, based on our research, to possibly give them meaningful information about their condition. It’s very rewarding to be able to connect a

Prior to starting his residency, Marius A. Tijunelis, M.D., M.B.A., spent a year at Kellogg as an Innovation Fellow through the U-M Medical Innovation Center. The purpose of this fellowship was to invent, develop and take to market a product that would solve a common problem in the field of ophthalmology.

Dr. Tijunelis and his colleague, David Lorch, Ph.D., who was also an Innovation Fellow, designed and produced an eye-drop-assist device, the DROPin™. The device fits most types of eye drop bottles and stabilizes the bottle for one-handed use. Once the cap is removed, the bottle is placed through the hole in the device.

The triangular end of the DROPin™ rests on the bridge of the nose and the tip of the bottle is centered over the eye. The free hand is then used to hold open the eye while the drop is applied.

In July 2013, the DROPin™ became available for purchase on amazon.com, at Kellogg’s Optical Shop and at a handful of pharmacies in the Ann Arbor area.

More than 500 DROPin™ devices have been sold to date.

Now in his second year of residency, Dr. Tijunelis has noticed that many patients have difficulty properly instilling their medicated eye drops. “I believe that this device helps patients accurately instill their medications resulting in fewer wasted drops and lower medication cost over time,” says Dr. Tijunelis.

person to a research finding.”

17

Pediatric optometrist Courtney Dewey, O.D., examines patients at the Ypsilanti Community High School eye clinic.

EYE CARE GOES BACK TO SCHOOL

services such as physical examinations, immunizations, laboratory testing and counseling.

Kellogg equipped the eye clinic for Dr. Dewey, who exam-

ines patients two Tuesdays per month, serving approximately 10 students per day. She initially worked through a backlog of

Kellogg Partners to Bring Vision

students who needed vision care. When the public schools are

Care Services to Underserved Areas

in session, Dr. Dewey has a steady stream of 7th through 12th graders who come to the clinic if they are having visual symp-

A few years ago, Kellogg optometrist Courtney A. Dewey, O.D.,

toms or are referred by other members of the medical team.

spoke to Ypsilanti middle-school students about eye health. That

talk sparked a partnership between Kellogg and the University

Optical Shop staffers, who obtain the information from

of Michigan Health System (UMHS) Regional Alliance for

Mi-Chart, UMHS’ electronic medical records system, and ar-

Healthy Schools (RAHS) to establish an eye clinic at Ypsilanti

range for the eyeglasses to be manufactured. One of Kellogg’s

Community High School.

opticians then delivers the eyeglasses to the clinic in Ypsilanti.

RAHS, whose mission is to provide school-based health

If students need eyeglasses, Dr. Dewey notifies Kellogg’s

“RAHS is a great program that has really flown under the

programs and clinical services that improve the well-being of

radar,” says Dr. Dewey. “It’s a great example of how UMHS

students, their families and communities, was looking for a way

can help schools serve students and the community. Kellogg

to provide vision services to Ypsilanti’s underserved areas. Dr.

would love to eventually have a presence in all RAHS locations

Dewey knew Kellogg could help. In February 2015, the Com-

and to serve as a model for comprehensive school-based health

munity Eye Clinic opened as part of a newly-renovated, school-

centers statewide.”

based health center featuring a U-M medical team that provides

KELLOGG FACULTY MEMBER RECOGNIZED FOR LEADING OPHTHALMOLOGY AT THE HOPE CLINIC Providing Ophthalmic Care for the Uninsured in Our Community

18

Paula Anne Newman-Casey, M.D., M.S., Assistant Professor, is the recipient of the 2015 University of Michigan Medical School (UMMS) Dean’s Award for Local Community Service for her efforts as the director of the Hope@UMHS-KEC ophthalmology clinic program to provide ophthalmic care for the uninsured in Ann Arbor and the surrounding areas.

"It is quite an honor to receive this award and I feel that it is really a shared accomplishment with all of the faculty and staff from the Kellogg Eye Center who have generously donated their Saturday mornings to provide eye care for those in our community who do not have insurance,” says Dr. Newman-Casey. “Over the last four years, we have provided ophthalmic care to over 850 patients who would have otherwise gone without. I know this program will continue into the future because my colleagues are just that generous."

Recognizing UMMS faculty that have made extraordinary contributions to the local, national or global community, this honor carries a $5,000 discretionary academic award.

Innovative Safety CheckList Improves Quality of Patient Care

Jennifer S. Weizer, M.D., director of the Kellogg Quality Assurance team, recently led efforts to devise an innovative safety

VA Chief of Ophthalmology Denise John, M.D., oversees the VA eye clinic.

EXPANDING AT THE VA More Space, More Services to Care for Veterans The University of Michigan Medical School and the VA Ann Arbor Healthcare System (VA) have a decades-long history of collaborating to provide outstanding health care to military veterans. Kellogg is the main eye care provider at the VA, where more than 90 patients per day are seen. To better handle growing patient volume, the VA eye clinic recently underwent an expansion.

The renovated clinic increased in size from 10 to 17 exam lanes, all with updated

equipment. To improve patient flow, ophthalmology services have been moved to one side of the clinic and optometry services are on the other. Kellogg has also gained access to more operating room space 6-8 times per month.

In addition, Kellogg has added more providers so that there are now 20 physi-

cians providing VA care each week. To supplement comprehensive care, Kellogg offers a different subspecialty clinic each day. The physicians are supported by a clinic supervisor, 11 ophthalmic technicians and six residents.

“In recent years, improving patient access while maintaining our high quality has

been our goal,” says Denise A. John, M.D., FRSCS, Assistant Professor and Chief of Ophthalmology at the VA. “And with more providers, more exam lanes, more technicians and more surgery time, we are better able to meet the demands of our patients.”

Dr. John oversees the day-to-day operations of the eye clinic, including the residents who complete two, seven-week rotations in each year of their training program. A new feature is a resident continuity clinic, which allows two third-year residents and four second-year residents to manage—with the appropriate level of faculty supervision—their own patients.

“The veterans are extremely appreciative of the care they receive,” says Dr. John.

“And we all work together as a team to put them first.”

checklist program for ophthalmologists to use in the operating room before, during and after surgery. Once it was put into place, the team monitored surgical adherence to the checklist.

Results were shared with Kellogg surgeons and staff and then educational interventions were instituted, which led to improved adherence rates.

“Collaboration and open communication among our surgical team were the keys to improving adherence rates and making the operating room an even safer place for our patients,” says Dr. Weizer.

Upon completion of the checklist project, Dr. Weizer worked with both the University of Michigan Health System and the American Board of Ophthalmology Maintenance of Certification (ABO MOC) programs to obtain approval for Kellogg surgeons to earn ABO MOC credit for their participation.

The ABO MOC program is a patientcentered, continuous professional development tool designed to assess and develop the core competencies essential for providing high-quality patient care. Kellogg’s checklist met the certification requirements of Part 4 of the program—Demonstrating Quality Improvement.

“This is the first program of its kind in the country for which the ABO has granted this type of credit,” says Dr. Weizer.

“More importantly, it improves patient safety by making it easier for our faculty to achieve the goals of the ABO MOC program.”

19

KELLOGG IS RECIPIENT OF $3.5M GIFT FROM THE JEROME JACOBSON FOUNDATION Gift Establishes the Jerome Jacobson Professorship and Vision Research Fund

Jerome Jacobson suffered from glaucoma for most of his life.

Paul Lichter, M.D., M.S., Paul Lee, M.D., J.D., and Mr. and Mrs. John Breen.

Diagnosed as a young adult, Mr. Jacobson’s vision presented daily concerns and challenges for him. “In all the time I spent with Jerry, I never knew a day or occasion where, at least in

Foundation with co-trustee Louis P. Rubinfield, a relative of Mr.

some way, sight didn’t come up,” says John R. Breen, longtime

Jacobson. “It is our hope that these endowments will ensure

friend and co-trustee of the Jerome Jacobson Foundation.

that the Eye Center continues to make strides toward eventually

“It was a serious fight he had with the disease.”

conquering glaucoma.”

In the early 1970s, just after relocating to Michigan,

Mr. Jacobson became a patient of Kellogg glaucoma special-

guished career as an economist, holding management posts for

ist Paul R. Lichter, M.D., M.S., Professor, a relationship that

both the Bendix Corporation and Burroughs Corporation in

endured until Mr. Jacobson passed away in 2008.

Michigan, and as president of Robert Nathan Associates, an

Mr. Breen describes Mr. Jacobson as a

economic consulting firm headquartered in

passionate philanthropist, supporting a long

“It is our hope that these endowments

list of causes with an eye toward fairness and

will ensure that the Eye Center contin-

Assistant Secretary for Economic Affairs in

the Kellogg Eye Center, which became a focus

ues to make strides toward eventually

Kennedy administration.

of the Foundation’s priorities over the past

conquering glaucoma.”

justice. One of his philanthropic causes was

seven years with major grants awarded for basic research in glaucoma and international

—John R. Breen

Last year, the Jerome Jacobson Foundation awarded

Washington, D.C. He also served as Deputy the U.S. State Department during the John F. “As I came to know Mr. Jacobson over more than 35 years, I began to realize that he was a particularly careful and thorough person in everything he did,” says Dr.

ophthalmology efforts.

20

Born in New Jersey in 1921, Mr. Jacobson built a distin-

Lichter. “The fact that he chose Kellogg as the institution

Kellogg a gift in the amount of $3.5M to support the establish-

where he would receive his glaucoma care was an important

ment of the Jerome Jacobson Professorship, a fully endowed

vote of confidence, especially after he relocated to Washington,

glaucoma professorship ($2.5M), and the endowed Jerome

D.C., yet continued to fly back to Michigan to see me regularly

Jacobson Vision Research Fund ($1M). The gift was announced

for his care. We became good friends.”

by Mr. Breen at Kellogg’s 30th Anniversary celebration held at

the University of Michigan Museum of Art.

philanthropy was as careful as his selection of medical care.

“Mr. Jacobson evaluated and thought about the causes that

“Jerry was a humble man. He was shy about putting his

Dr. Lichter explains that Mr. Jacobson’s approach to

name to his philanthropy and usually gave gifts anonymously.

he decided to support. His decision to support Kellogg was an-

This time, we wanted to endow a professorship in Jerome

other important endorsement,” says Dr. Lichter. “Mr. Jacobson

Jacobson’s name, highlighting his belief in the work that is done

considered Kellogg to be on the cutting edge of research and

at the Kellogg Eye Center, as he was deeply appreciative of the

patient care and an organization that has what it takes to find

treatment he received there,” says Mr. Breen, who directs the

better treatments, and even a cure, for glaucoma.”

UPDATES ON GLAUCOMA RESEARCH AT KELLOGG Paula Anne Newman-Casey,

Philip J. Gage, Ph.D., Associate

M.D., M.S., Assistant Professor, has

Professor, studies Axenfeld-Rieger

created the eyeGuide, a counseling

Syndrome (ARS), a congenital

program supported by a web-based,

syndrome that is characterized by

tailored educational tool that ad-

abnormalities of the front part

dresses adherence rates to glaucoma

of the eye. Children with ARS

medications.

suffer from elevated intraocular

The program helps medical

pressure which can lead to early

assistants and technicians provide

onset glaucoma in over half of

high-quality, individualized patient

this young population.

counseling that might otherwise be

Unlike glaucomas that develop

possible only with an ophthalmologist. It begins by showing pa-

in adults, ARS is particularly resistant to conventional therapies

tients photographs of a healthy optic nerve, an optic nerve with

and surgical techniques. To address these challenges, Dr. Gage

glaucoma and their own optic nerve so that they can see the

and his team have generated a designer mouse model to study

disease progression. The eyeGuide also features patient stories

what Pitx2, a type of regulatory gene in the cell, does in the

to address specific issues such as the expense or side effects of

normal course of eye development. “We study the outcomes

glaucoma medications. It concludes with the development of an

when the lab genetically mimics what happens in patients who

action plan to help patients integrate taking glaucoma medica-

suffer from this disease,” says Dr. Gage. “One amazing find-

tions into their daily routine.

ing is that this model develops a similar ocular disease to what

humans develop, with alterations in the anterior ocular segment,

“At least one third of glaucoma patients do not take their

medications regularly, creating a significant segment of people

elevated intraocular pressure and optic nerve head cupping.”

who go on to develop needless vision loss,” says Dr. NewmanCasey. “We’ve found that this personalized approach really

Julia E. Richards, Ph.D., the

resonates with our glaucoma patients.”

Harold F. Falls Collegiate Professor of Ophthalmology and Visual

Brenda L. Bohnsack, M.D., Ph.D.,

Sciences, and Sayoko E. Moroi,

Assistant Professor, is studying

M.D., Ph.D., Professor, have joined

the PAX6 gene and its mutations

the International Glaucoma

that are associated with aniridia,

Genetics Consortium to study

an eye disorder that leads to mal-

samples from more than 35,000

formation of almost all structures

subjects for genetic risk factors

of the eye. Approximately 50

associated with glaucoma.

percent of individuals with aniridia

“Through the use of genome-

have glaucoma and the disorder

wide technologies, this group identified four new genetic risk

can be difficult to treat and can

factors for elevated intraocular pressure, the only known

lead to significant vision loss and blindness.

modifiable risk factor for glaucoma,” says Dr. Richards.

“The group also provided data to confirm three other genetic

To learn more about PAX6, Dr. Bohnsack and her team

are collaborating with the U-M Human Embryonic Stem Cell

risk factors for glaucoma that are associated with elevated

Center. “We have human embryonic stems cells which were

intraocular pressure.”

derived from a family that is affected by aniridia and carries a

mutation in PAX6,” says Dr. Bohnsack. “We are characterizing

was invaluable to the study. “We were able to assemble a large

these mutant stem cells to better understand the role of this gene

enough study population to let us detect genetic risk factors that

in early human development and as a stepping-off point for

were not detectable in the smaller study populations assembled

creating potential stem cell treatments for those with aniridia.

by each of the separate research groups,” says Dr. Richards.

With this information, we can try to regenerate or reverse the

“The samples and data contributed by the group represented

dysfunctional tissue we see in this condition.”

more than 20 years of work by many doctors and researchers.”

Pooling the resources of many different research groups

21

H. Kaz Soong, M.D., Jonathan Trobe, M.D., Monte Del Monte, M.D., Thomas Lietman, M.D., Paul Lee, M.D., J.D., Christine Nelson, M.D., Timothy Johnson, M.D., and Joseph Kolars, M.D., at Kellogg's third International Night.

FORGING NEW RELATIONSHIPS IN GLOBAL OPHTHALMOLOGY The Kellogg Eye Center for International Ophthalmology Facilitates International Clinical and Research Activities The Kellogg Eye Center for International Ophthalmology held its third annual International Night on October 12, 2015.

The keynote speaker was 2015 Scholar-in-Residence Thomas Lietman, M.D., the Ruth Lee and Phillips Thygeson Distinguished Professor and Director of the F. I. Proctor Foundation for Research in Ophthalmology at the University of California, San Francisco. The Foundation was established in 1947 with the purpose of eradicating trachoma worldwide. Dr. Lietman

Thomas Lietman, M.D., and Zvi Kresch, M.D.

delivered a presentation Will the Last Case of Trachoma Please Stand Up?

22

Dr. Lietman’s work centers around mass antibiotic distribu-

and infectious corneal ulcers, working in Egypt, Nepal,

tions for eliminating trachoma and the possible collateral effects

Ethiopia, India and Niger. Dr. Lietman has been the principal

of these distributions, including selecting for resistant organisms

investigator on several NIH-NEI and Gates Foundation random-

and impact on childhood mortality. “At the Proctor Founda-

ized trials. He is also part of the infectious disease modeling

tion, we’re looking for research questions where, if we are lucky

group at Proctor.

enough, an answer could have leverage and impact on a far

larger population,” says Dr. Lietman. “Whether that research

reasonable solution for controlling trachoma with mass anti-

is done in San Francisco— or Nepal, Ethiopia or South India—

biotic treatments and other measures. “I think we’re going to

that’s what we’re looking for.”

be able to control the disease to a level that the World Health

Organization currently sees as satisfactory,” says Dr. Lietman.

For the past 20 years, Dr. Lietman has studied trachoma

Dr. Lietman explained that, at the present time, there is a

Gurpreet Rana, MLIS, media specialist at the Taubman Health Sciences Library, speaks to Tania Piotrowski, administrative director of U-M Global Reach, during International Night.

Roland Chen, Ph.D., Research Investigator at the U-M College of Engineering.

“I’m a little worried about what is going to happen after that.

members also teach abroad, so it’s really a very reciprocal

I don’t think trachoma is going to rebound and come back with

relationship.”

a vengeance if we stop control programs, but I do think we have

an opportunity to completely eradicate trachoma. And if we

medical student clerkship director, served as moderator for this

don’t jump on that opportunity now, I don’t think the resources

event. Presentations included: 1) An Academic Approach to

are going to be available in the future.

Ariane D. Kaplan, M.D., Instructor and ophthalmology

Global Health Engagement by Timothy

Trachoma could become a forgotten dis-

“I think the Kellogg Eye Center is perhaps

ease and linger on for a few decades if we

the leader in the educational aspect of

of the U-M Department of Obstetrics and

hand, trachoma could be the first bacterial

global health. Kellogg is really living the

Starting out in Global Health by Vicky

disease that we eradicate.”

idea that teaching goes both ways.”

Koski-Karell, M2; 3) Engineering Inno-

—Thomas Lietman, M.D.

Research in Ophthalmology by Roland

don’t stamp it out right now. On the other

Dr. Lietman expressed great admira-

tion for the scope of Kellogg’s international program. “The Kellogg Eye Center for

R.B. Johnson, M.D., Professor and Chair Gynecology; 2) Planting Rice in Haiti:

vations for Patient Care, Teaching, and Chen, Ph.D., Research Investigator at the

International Ophthalmology has quickly become one of the

U-M College of Engineering; and 4) Kellogg in Ethiopia by

leading programs in the country. It’s difficult to believe that it

Zvi A. Kresch, M.D., Instructor.

has only been in existence for three years,” says Dr. Lietman.

“The Center has forged strong international collaborations with top institutions on different continents. While I knew that the U-M Department of Ophthalmology was one of the preeminent departments in the world, this visit let me see how wonderful the people are at this institution.”

Dr. Lietman commented on the components of global

outreach in academic health centers, including patient care, education and research. “I think the Kellogg Eye Center is perhaps the leader in the educational aspect of global health,” he says.

“Kellogg is really living the idea that teaching goes both ways.

Residents at Kellogg, along with fellows and medical students at the University of Michigan Health System, have the opportunity to travel to incredible locations and hospitals around the globe to meet amazing physicians and surgeons who can teach them about complex eye diseases. In turn, those physicians and surgeons can come to to Kellogg to participate. Kellogg faculty

Donna Donato, administrative director of the Center for International Ophthalmology, Kellogg faculty member Christine Nelson, M.D., Dayakar Yadalla, M.D., oculoplastic surgeon and residency program director at the Aravind Eye Care System (Pondicherry), and Kellogg faculty member César Briceño, M.D. 23

Jonathan Greene, M.D., (left), and Monte Del Monte, M.D., (right), with Elias Hailu Gebreab, M.D., President of the Ophthalmological Society of Ethiopia.

Michael Smith-Wheelock, M.D., with Bezawit Tadegegne, M.D., Chair of Ophthalmology, and Lemlem Tamrat, M.D., Director of the Ophthalmology Residency Program, at St. Paul’s Hospital in Addis Ababa, Ethiopia.

KELLOGG TEAM HELPS ETHIOPIAN HOSPITAL ESTABLISH A WORLD-CLASS RESIDENCY TRAINING PROGRAM Jonathan B. Greene, M.D., Assistant Professor, and Monte A.

instrumental in elevating the quality of eye care not only in

Del Monte, M.D., the Skillman Professor of Pediatric Ophthal-

Ethiopia but in the entire East Africa region.”

mology, led the Kellogg team that has served as advisors to

St. Paul Hospital Millennium Medical College in Addis Ababa,

During the preliminary stages of development, Drs. Tadegegne and Tamrat spent an intensive week at Kellogg visiting the

Ethiopia, in establishing a four-year residency

clinics and operating rooms, attending confer-

training program for ophthalmologists.

"We hope to assist our Ethiopian

ences and interviewing residents and faculty

Drs. Greene and Del Monte collaborated

colleagues in building a training

to find out how our program works. “We are

Tadegegne, M.D., and Ophthalmology

program and eye care center that

energy and determination to succeed in this

Program Director Lemlem Tamrat, M.D.,

will become a regional center of

critical enterprise in ophthalmic education,”

excellence.”

co-director of the Kellogg Eye Center for Inter-

with St. Paul’s Ophthalmology Chair Bezawit

in developing the new program, one of only four such programs in Ethiopia.

“The first six residents began their train-

ing last September and we are excited to see

—Jonathan B. Greene, M.D.

how our faculty and experience with medical

impressed with the Hospital’s knowledge,

says Jonathan D. Trobe, M.D., Professor and national Ophthalmology.

The initiative was spearheaded by Senait Fisseha, M.D., Professor of Obstetrics and

education can be used to enable the growth of their program,”

Gynecology at the University of Michigan, who has had a major

says Dr. Greene. “We hope to assist our Ethiopian colleagues

role in developing training programs in obstetrics and gynecol-

in building a training program and eye care center that will

ogy, internal medicine, radiology and general surgery at St. Paul

become a regional center of excellence. Graduates will be

Hospital Millennium Medical College.

Since July 2014

43 INTERNATIONAL VISITORS TRAVELED FROM 16 DIFFERENT COUNTRIES 18 FACULTY MEMBERS TRAVELED TO 20 COUNTRIES WORLDWIDE 24

The University of Michigan A. Alfred Taubman Medical Research Institute is housed in the Biomedical Science Research Building.

TWO KELLOGG FACULTY ARE AWARDED TAUBMAN MEDICAL RESEARCH INSTITUTE HONORS Kellogg scientists and their laboratory groups work

Rajesh C. Rao, M.D., Assistant Professor,

steadily to find new treatments and cures for blinding

was appointed the Leslie H. and Abigail S. Wexner Emerging Scholar by the University

eye diseases, such as diabetic retinopathy, age-

of Michigan A. Alfred Taubman Medical

related macular degeneration and retinitis pigmen-

Research Institute. Dr. Rao’s research focuses

tosa. The University of Michigan A. Alfred Taubman

on using stem cell biology and epigenetics as languages to decipher the pathogenesis of

Medical Research Institute plays a key role in funding our research initiatives.

retinal disease and future treatments. With this award, he will receive support for his research for a period of five years at $50,000 per year for the first three years and

Thomas W. Gardner, M.D., M.S., Profes-

sor, was named a Taubman Institute Scholar by the University of Michigan A. Alfred Taubman Medical Research Institute. Dr. Gardner’s research focuses on understanding why diabetes damages the retina, with the goal of helping people with the disease maintain their vision.

$25,000 per year for the last two years.

“I am grateful for the transformative gift that Mr. and

Mrs. Wexner and the A. Alfred Taubman Medical Research Institute have provided to further our work in finding new ways to diagnose and treat blinding eye diseases,” says Dr. Rao. “Their support will enable us to use epigenetics and stem cell biology to better understand the basic biological mechanisms that control stem cell behavior so that cells

With this honor, he will receive a three-

“It would be very difficult to conduct this

that are lost in blinding eye diseases can be

year renewable research grant of $50,000

early-stage work without the support of

collaborative, precision medicine efforts with

annually, followed by $5,000 per year

regenerated. Their gift will accelerate our

indefinitely.

the Taubman Institute. Mr. Taubman has

fellow Taubman Scholars to link patients

left an enduring legacy for which we are

treatments based on a tumor's unique genetic

“The Taubman Institute fosters high-

risk new ideas and this funding provides

with lethal diseases like eye cancer to targeted

the opportunity to determine if retinal func-

most grateful.”

and epigenetic profile.”

tion can be restored in people who have

—Thomas W. Gardner, M.D., M.S.

gram was created to support and encourage

diabetic retinopathy,” says Dr. Gardner.

“It would be very difficult to conduct this early-stage work without the support of the Taubman Institute. Mr. Taubman has left an enduring legacy for which we are most grateful.”

The Institute’s Emerging Scholars Proearly-career physician-scientists whose labo-

ratory work aims to translate basic research into new treatments for disease. The program connects U-M Medical School faculty members at the assistant professor level with philanthropists who pledge to support the physicians’ research.

25

KELLOGG FACULTY MEMBER LEADS SOCIETY OF RETINAL SPECIALISTS IN THE U.S.

Prior to taking over as president, Dr. Johnson served on the

Society’s executive committee for six years. He was elected secretary in 2009 and then served as treasurer and vice president.

Throughout his 25-year career, Dr. Johnson, who is a fellow of the American Academy of Ophthalmology (AAO), has amassed many accolades, including the AAO Honor Award (1995) and the AAO Senior Achievement Award (2005). He was elected to active membership in the American Ophthalmological Society in 2005 and is recognized in Best Doctors in America and Guide to America’s Top Physicians. Dr. Johnson has served as the Associ-

For the first time in its history, the

ate Examiner for the American Board of Ophthalmology since

Retina Society and its 650 distin-

1995 and serves on the editorial boards of the American Journal

guished members are being led by

of Ophthalmology, Retina and Retinal Physician.

a Kellogg physician. At the 48th

annual meeting of the Society in

clinical research interests include pharmacotherapies for macular

Paris last year, Mark W. Johnson,

diseases and pathogenesis and treatment of vitreomacular

M.D., Professor, began his two-

interface disorders. Dr. Johnson served as principal investigator

year term as president.

and Data and Safety Monitoring Committee member for numer-

“It is a tremendous privilege

Dr. Johnson heads Kellogg’s Retina and Uveitis Service. His

ous national multicenter clinical trials in age-related macular

for me to have this opportunity

degeneration, retinal vascular disease and vitreoretinal disorders.

to serve my wonderful colleagues

He lectures widely on topics in macular and vitreoretinal disease

in the Retina Society who have

and has published over 175 articles and book chapters. Dr.

been huge sources of inspira-

Johnson completed medical school at the University of Utah in

tion throughout my career,” says Dr. Johnson. “I believe this

1984 and residency at Kellogg in 1988, serving as chief resident

appointment is, in part, an indication of the esteem with which

in his final year. He completed medical retina and vitreoretinal

ophthalmologists around the country regard the programs

surgery fellowships at the Bascom Palmer Eye Institute in 1990

and faculty of the Kellogg Eye Center and the University of

and then joined the Kellogg faculty as an assistant professor.

Michigan.”

KELLOGG RETINAL SPECIALIST AWARDED THE RETINA SOCIETY AWARD OF MERIT IN RETINA RESEARCH Thomas W. Gardner, M.D., M.S., Professor, is the recipient of the Retina Society Award of Merit in Retina Research honoring Charles L. Schepens. This honor recognizes outstanding national achievement in retina research and provides a $50,000 cash prize that includes $45,000 for the recipient’s research and a $5,000 honorarium. The award was presented at the annual meeting of the Retina Society in Paris.

“The Award of Merit in Retina Research is greatly appreciated because it is given by the Retina Society, a leading international organization of retinal 26

specialists,” says Dr. Gardner. “This award recognizes the contributions of many faculty members at the Kellogg Eye Center.

The funds from the prize will support additional research.”

The mission of the Retina Society is to reduce worldwide visual disability and blindness by promoting the education and professional interaction of vitreoretinal specialists, providing optimal care for patients with vitreoretinal diseases, and encouraging, through clinical and basic research, the discovery and development of new means to further patient care.

RESIDENTS AND FELLOWS Department of Ophthalmology and Visual Sciences

Kellogg Fellow Awarded the Retina Society’s Margherio Award

Our residents and fellows are the future leaders in ophthalmology and visual sciences. After training, most residents go on to fellowships at other major institutions and our fellows pursue their subspecialties in private practice or at academic medical centers. See where our 2015 graduating residents and fellows are now: 2015 GRADUATING RESIDENTS Courtney Y. Kauh, M.D., M.S., fellow in oculoplastics, University of Wisconsin, Madison, Wisconsin Mehnaz Khan, M.D., M.S., fellow in vitreo-retinal surgery, Cleveland Clinic, Cleveland, Ohio Lee M. Kiang, M.D., Ph.D., Graduate Chief Resident, Kellogg Eye Center, Ann Arbor, Michigan Matthew W. Manry, M.D., comprehensive ophthalmologist, Kellogg Eye Center, Ann Arbor, Michigan. He will enter a vitreo-retinal fellowship.

Catherine S. Choi, M.D., assistant professor and pediatric ophthalmology and strabismus specialist, Tufts University, Boston, Massachusetts Steven R. Cohen, M.D., retina specialist, Retina Associates, PA, Kansas City, Missouri Marina A. Eisenberg, M.D., pediatric ophthalmology and strabismus specialist, Cleveland Clinic, Cleveland, Ohio Kristopher M. Kowal, M.D., neuro-ophthalmology specialist, Surrey Memorial Hospital, Surrey, British Columbia

Devon Ghodasra, M.D., Kellogg vitreoretinal surgical fellow, won the prestigious Raymond R. Margherio Award at the 48th Annual Retina Society Meeting in Paris last year for his research on vitreous cytokines.

Established to support research into

macular disease and the development of new technologies for macular surgery, the fund supports an award to a vitreoretinal fellow of an active member of

Monica A. Michelotti, M.D., fellow in vitreo-retinal surgery, Oregon Health & Science University, Portland, Oregon

Andrew W. Lewis, M.D., glaucoma specialist, U.S. Army, Wilford Hall Ambulatory Surgical Center, San Antonio, Texas

Melisa Nika, M.D., fellow in glaucoma, Kellogg Eye Center, Ann Arbor, Michigan

Steven G. Odaibo, M.S., M.D., retina specialist, Medical Associates, Dubuque, Iowa

travel and lodging costs of attending the

Andrew W. Stacey, M.D., M.S., fellow in ocular oncology, Moorfields Eye Hospital, NHS Foundation Trust, London, England

Dolly A. Padovani-Claudio, M.D., Ph.D., assistant professor and pediatric ophthalmology and strabismus specialist, Vanderbilt University, Nashville, Tennessee

Fatemeh Rajaii, M.D., Ph.D., assistant professor and oculoplastics specialist, Johns Hopkins University, Baltimore, Maryland

M.D., Ph.D.

2015 GRADUATING CLINICAL FELLOWS Victoria M. Addis, M.D., assistant professor and glaucoma specialist, University of Pennsylvania, Philadelphia, Pennsylvania Sejal Rajendra Amin, M.D., cornea specialist, Henry Ford Hospital, Detroit, Michigan Lulu Bursztyn, M.D., FRCSC, assistant professor and neuro-ophthalmology specialist, Western University, London, Ontario

Daniel Sand, M.D., cornea specialist, Kaiser Permanente Medical Group, Los Angeles, California 2015 GRADUATING RESEARCH FELLOWS

the Society. Dr. Ghodasra was sponsored by Professor Thomas W. Gardner, M.D., M.S. The award covered the annual meeting, where Dr. Ghodasra presented his research findings.

Dr. Ghodasra is Kellogg’s second

recipient of the Margherio Award, joining former fellow Edward F. Hall, M.D., who won the award in 2008 with the support of Professor David N. Zacks,

FELLOWSHIPS AT KELLOGG To learn more about the fellowship opportunities at Kellogg, visit: www.kellogg.umich.edu/education/ fellow.html

Mark T. Bolinger, Ph.D., Molecular and Integrative Physiology, University of Michigan, Ann Arbor 27

Brenda Bohnsack, M.D., Ph.D., and Joshua Stein, M.D., M.S., earn career development professorships to further their research.

KELLOGG FACULTY MEMBERS EARN PROFESSORSHIPS TO ADVANCE THEIR PROMISING RESEARCH

28

Two of Kellogg’s most capable young faculty members earned

believes in bolstering the University's excellence as a whole.

career development professorships to advance their research.

He is a longtime supporter of the mission of the Kellogg Eye

Brenda L. Bohnsack, M.D., Ph.D., Assistant Professor, was in-

Center and served as chairman of the Community Advisory

stalled as the Helmut F. Stern Career Development Professor of

Board for Kellogg’s expansion campaign.

Ophthalmology and Visual Sciences, and Joshua D. Stein, M.D.,

M.S., Associate Professor, was installed as the Edward T. and

Cataract, and Anterior Segment Disease Service, heads Kellogg’s

Ellen K. Dryer Career Development Professor in Ophthalmol-

Center for Eye Policy and Innovation, which performs cutting-

ogy and Visual Sciences. Both professorships were established to

edge research that translates billions of individual data points

provide junior faculty with important research support and are

into results that can ultimately save patients’ vision and improve

held for five years.

their lives.

Dr. Bohnsack, a member of the Pediatric Ophthalmology

Joshua D. Stein, M.D., M.S., a member of the Glaucoma,

“I am enormously grateful to the Dryer Charitable Foun-

and Adult Strabismus Service, as well as the Glaucoma, Cata-

dation for supporting our ongoing efforts to push technologi-

ract, and Anterior Segment Disease Service at Kellogg, special-

cal boundaries with the ultimate aim of improving the quality

izes in the medical and surgical management of congenital

and affordability of eye care and patients’ access to it,” says

eye diseases. The goal of her research is to create molecularly

Dr. Stein. “Edward and Ellen Dryer’s beautiful decades-long

targeted therapies to cure these diseases.

partnership and their respective pioneering careers will provide

meaningful inspiration as my colleagues and I forge ahead

“This professorship will allow me to continue my work in

understanding the basis of congenital eye diseases in the hopes

with exciting collaborative research projects.”

of applying this knowledge to prevent childhood blindness,”

says Dr. Bohnsack.

from Dartmouth Medical School in 1997 and his M.D. from

Thomas Jefferson University in 2001. He completed his residen-

Dr. Bohnsack earned her Ph.D. in molecular and cellular

Dr. Stein earned his M.S. in Evaluative Clinical Sciences

biology in 2004 and her M.D. in 2006 from the Baylor Col-

cy at New York University (2005) and a Glaucoma fellowship

lege of Medicine. She went on to complete her residency (2010)

at Duke University (2007). Dr. Stein joined the faculty at Kellogg

and a postdoctoral fellowship (2011) at Kellogg and a Pediatric

in 2007 and then earned a second M.S. in Health and Health

Ophthalmology and Adult Strabismus fellowship at Duke

Care Research at U-M in 2010.

University (2012). Dr. Bohnsack then returned to Kellogg to

join the faculty.

Foundation, which was formed through the estate of the Dryers,

who lived in Detroit and passed away within months of each

The Stern Professorship, previously held by Alon Kahana,

The Dryer Professorship was established by the Dryer

M.D., Ph.D., Associate Professor, was established by Mr. Stern,

other in 2010. Mr. Dryer, an international banking executive,

an Ann Arbor businessman and philanthropist. Mr. Stern grew

was struck with blindness in the middle of his career. Mrs. Dryer

up in Germany and settled in Ann Arbor in 1942, where he

was an advertising pioneer who served as the first woman media

served as president of Industrial Tectonics and later as president

director at W.B. Doner & Company. The Dryer Professorship

of Arcanum Corporation. Mr. Stern generously supports numer-

was previously held by Grant M. Comer, M.D., M.S., Assistant

ous schools and projects at the University of Michigan and

Professor.

Meet Kellogg’s New Faculty Angela R. Elam, M.D., clinical lecturer, has joined the faculty of the Glaucoma, Cataract, and Anterior Segment Disease Service and sees patients in Kellogg’s Northville and Ypsilanti offices. Dr. Elam earned her medical degree from Duke University and completed her residency at the University of Pittsburgh.

She then completed her fellowship in glaucoma at Kellogg. Dr. Elam’s research focuses on disparities in eye care, eye care utilization and health services.

Yannis M. Paulus, M.D., assistant professor, has joined the faculty of the Retina and Uveitis Service and sees patients in Kellogg’s Grand Blanc office. Dr. Paulus earned his medical degree and completed his residency at Stanford University. He then completed a medical and surgical vitreoretinal fellowship at the Wilmer Eye Institute of Johns Hopkins University. Dr. Paulus holds a joint appointment in the U-M Department of Biomedical Engineering and his research focuses on the development of novel retinal imaging systems and therapeutic techniques and technologies, including photoacoustic imaging, molecular imaging, restorative retinal laser therapy and surgical techniques.

Julie M. Rosenthal, M.D., clinical instructor, has joined the faculty of the Retina and Uveitis Service and sees patients in Kellogg’s Grand Blanc office as well as at the VA Ann Arbor Healthcare System. Dr. Rosenthal earned her medical degree from the University of Pennsylvania and completed her residency at the Wills Eye Institute of Thomas Jefferson University. She completed her fellowship in vitreoretinal surgery at the Casey Eye Institute at the Oregon Health & Science University and, before joining Kellogg, Dr. Rosenthal served as a retinal specialist at Retinal and Ophthalmic Consultants, P.C., in Northfield, New Jersey.

Manjool Shah, M.D., clinical instructor, has joined the faculty of the Glaucoma, Cataract, and Anterior Segment Disease Service and sees patients in Kellogg’s Ann Arbor and Grand Blanc offices. Dr. Shah earned his medical degree from Washington University in St. Louis and completed his residency at the Casey Eye Institute at the Oregon Health & Science University. He then completed a fellowship in glaucoma and advanced anterior segment surgery at the University of Toronto.

Upcoming CME Programs Each year, Kellogg offers an informative series of continuing medical education programs designed to share new approaches to the diagnosis and management of eye disease across subspecialties. Below are our upcoming programs: Saturday, March 12, 2016 Tri-City Regional Update Conference 9 a.m. – noon The Conference Center at Apple Mountain Freeland, Michigan Application will be submitted for 3.0 AMA PRA Category 1 continuing medical education credits

Friday, September 30, 2016 22nd Annual Fall Reunion Day 8 a.m.– 4:15 p.m.

Kellogg Eye Center Ann Arbor, Michigan

Friday, June 10 – Saturday, June 11, 2016 88th Annual Spring Postgraduate Conference and 32nd Annual Research Day 8 a.m.– 5 p.m.

Kellogg Eye Center Ann Arbor, Michigan

Application will be submitted for 5.5 AMA PRA Category 1 continuing medical education credits.

Application will be submitted for 15.0 AMA PRA Category 1 continuing medical education credits.

For questions, contact Jennifer Burkheiser, CME Coordinator, at 734.763.2357 or kelloggCME@umich.edu.

For more information or to register for these programs, visit: www.kellogg.umich.edu/education/cmeoverview.html

29

FACULTY HONORS AND RECOGNITION

JULY 1, 2014 — SEPTEMBER 30, 2015

David A. Antonetti, Ph.D.

Monte A. Del Monte, M.D. (cont.)

Editor, Tissue Barriers

Grant Reviewer, Scientific Advisory Committee, National Priorities

Study Section, Diseases and Pathophysiology of the Visual System,

Research Program, Qatar National Research Fund

National Institutes of Health

Section Chair, Editorial Committee for Eye Wiki Online Encyclopedia,

Steven M. Archer, M.D. Best Doctors in America Castle Connolly Top Doctors Senior Achievement Award, American Academy of Ophthalmology Cagri G. Besirli, M.D., Ph.D. Best Doctors in America Top 40 under 40 Power List, The Ophthalmologist Commercial Relationships Committee, Association for Research in Vision and Ophthalmology Jill E. Bixler, M.D. Best Doctors in America Brenda L. Bohnsack, M.D., Ph.D. Best Doctors in America César A. Briceño, M.D. Best Doctors in America Grant M. Comer, M.D., M.S. Best Doctors in America Theresa M. Cooney, M.D. Best Doctors in America Regional Director, Michigan Society of Eye Physicians and Surgeons Wayne T. Cornblath, M.D. Best Doctors in America Lindsey B. De Lott, M.D. Best Doctors in America Monte A. Del Monte, M.D. America’s Top Doctors Castle Connolly Top Doctors Life Fellow, American Academy of Ophthalmology Lifetime Achievement Award, American Association for Pediatric Ophthalmology and Strabismus Chairman and Annual Meeting Organizer, American Association for Research in Strabismus Fellowship Directors' Committee, American Association for Pediatric Ophthalmology and Strabismus Grant Reviewer, Scientific Review Committee, Medical Advisory Board, Knights Templar Eye Research Foundation

30

American Academy of Ophthalmology Section Chair, Pediatric Ophthalmology and Strabismus, American Academy of Ophthalmology Senior Consultant, International Affairs Committee, American Association for Pediatric Ophthalmology and Strabismus Vice President and President-Elect, The Costenbader Pediatric Ophthalmology Society Hakan Demirci, M.D. Best Doctors in America Senior Achievement Award, American Academy of Ophthalmology Anwar Shah Retina Lecture, Alumni & Residents Day 2015, Department of Ophthalmology, St. Louis University Raymond S. Douglas, M.D., Ph.D. Best Doctors in America Susan G. Elner, M.D. Best Doctors in America Victor M. Elner, M.D., Ph.D. Best Doctors in America Castle Connolly Top Doctors Jerome I. Finkelstein, M.D. Best Doctors in America Patrice E. Fort, Ph.D., M.S. Academic Editor, Ophthalmology Research: An International Journal Editorial Board, Journal of Clinical and Experimental Ophthalmology Grant Reviewer, Research Grant Review Committee, American Diabetes Association Grant Reviewer, "Societal challenges” Grant Applications, French National Research Agency Grant Reviewer, “Tender offers” Grant Applications, Institut Carnot Voir et Entendre, Paris, France Bruce A. Furr, C.O., Ph.D. Lancaster Medal, American Association of Certified Orthoptists Board of Directors, Foundation for Orthoptic Research in America Christopher Gappy, M.D. Best Doctors in America Rules and Bylaws Committee, American Association for Pediatric Ophthalmology and Strabismus

FACULTY HONORS AND RECOGNITION

JULY 1, 2014 — SEPTEMBER 30, 2015

Thomas W. Gardner, M.D., M.S.

Paul P. Lee, M.D., J.D.

Best Doctors in America

Best Doctors in America

Gold Fellow, Association for Research in Vision and Ophthalmology

Castle Connolly Top Doctors

Associate Editor, Diabetes

Editorial Board, JAMA-Ophthalmology

Grant Review Panel, American Diabetes Association

Advisory Board, Hoskins Center for Patient Safety and Quality,

The Retina Society Award of Merit in Retina Research

Foundation of the American Academy of Ophthalmology

Charles L. Schepens Lecture, The Retina Society Annual Meeting

Board of Directors, American Board of Ophthalmology

3rd Joseph Sassani Alumni Lecture, Department of Ophthalmology,

Board of Governors/Immediate Past Chair, Association for

Penn State College of Medicine

Research in Vision and Ophthalmology Foundation

Hilary M. Grabe, M.D. Best Doctors in America John R. Heckenlively, M.D. Best Doctors in America Castle Connolly Top Doctors Associate Editor, Eye Editorial Board and Founding Editor, Documenta Ophthalmologica Grant Reviewer, National Institutes of Health Grant Reviewer, Foundation Fighting Blindness Grant Reviewer, Fight for Sight K. Thiran Jayasundera, M.D. Top 40 under 40 Power List, The Ophthalmologist Denise A. John, M.D. Best Doctors in America Mark W. Johnson, M.D. Best Doctors in America Castle Connolly Top Doctors President-Elect and Vice President, The Retina Society Editorial Board, American Journal of Ophthalmology, Retina, and Retinal Physicians Scientific Program Chair, The Retina Society Annual Meeting 2015 Mark J. Daily Retina Lecture, Department of Ophthalmology, Loyola University Alon Kahana, M.D., Ph.D. Best Doctors in America Editorial Board, Oculoplastic Surgery Section, Ocular Surgery News Editorial Group, Basic and Clinical Science Course, Section 2: Fundamentals, AAO Publications Physician-Scientist Award, Research to Prevent Blindness Joan & Gordon Bergy, M.D. Lecture in Vision Science, “Gained in Translation” Vision Conference, University of Washington

8th Annual M. Bruce Shields Lectureship, Yale University American Glaucoma Society Lecture, American Glaucoma Society Annual Meeting Robertson Lecture, University of Texas Medical Branch Shaffer-Hetherington-Hoskins Lecture, 19th Annual Glaucoma Symposium, Glaucoma Research Foundation J. Britto Distinguished Lecture, University of Sao Paulo, Sao Paulo, Brazil Paul R. Lichter, M.D., M.S. Best Doctors in America Castle Connolly Top Doctors Associate Editor, American Journal of Ophthalmology Foundation Board of Directors, International Council of Ophthalmology Knauer Lecture, American Eye Study Club Fralick Lecture, Department of Ophthalmology, University of Michigan Michael J. Lipson, O.D. Secretary, Scleral Lens Education Society Shahzad I. Mian, M.D. Best Doctors in America Castle Connolly Top Doctors Editorial Board, Cornea Guest Editor, Current Opinion in Ophthalmology Board of Directors, Cornea Society Board of Directors, Eye Bank Association of America Co-Chair, Cornea Sub-specialty Day, American Academy of Ophthalmology Council Credentials Committee, American Academy of Ophthalmology Medical Director, Eversight Michigan Program Directors Council, Association for University Professors in Ophthalmology Vice Chair, Accreditation Board, Eye Bank Association of America Vice Chair, Residency Review Committee, Accreditation Council for Graduate Medical Education Senior Achievement Award, American Academy of Ophthalmology

31

FACULTY HONORS AND RECOGNITION

JULY 1, 2014 — SEPTEMBER 30, 2015

Sayoko E. Moroi, M.D., Ph.D.

Donald G. Puro, M.D., Ph.D.

Best Doctors in America

Best Doctors in America

Cohen-Merck Lecture, 37th Midwest Glaucoma Symposium, Indiana University School of Medicine

Rajesh C. Rao, M.D.

David C. Musch, Ph.D., M.P.H.

Delegate, Congressional Briefing and Emerging Vision Scientists

Editorial Board, Eye and Vision

Reception, National Alliance for Eye and Vision Research Emerging

Editorial Board, JAMA Ophthalmology

Vision Scientists Program

Editorial Board, Retina

Editorial Panel, Innovative Retina Surgical Video Series, American

Advisory Group, Cochrane Collaboration Eyes and Vision Group

Society of Retina Specialists

US Project Ophthalmic Technology Assessment Committee, American Academy of Ophthalmology Preferred Practice Patterns Committee, American Academy of Ophthalmology Review Committee, Prevent Blindness Joanne Angle Investigator Award Grant Application Reviewer, Special Emphasis Panels, National Institutes of Health Scientific Reviewer, Health and Medical Research Fund and Innovation and Technology Support Programme, Government of the Hong Kong SAR, People’s Republic of China Scientific Reviewer, National Medical Research Council, Government of Singapore Chair, Data and Safety Monitoring Committee, Corneal Preservation Time Study, National Institutes of Health Chair, Data and Safety Monitoring Committee, Sirolimus Treatment of Geographic AMD, National Institutes of Health and Santen, Inc. Chair, Data and Safety Monitoring Committee, Study of Comparative Treatments for Retinal Vein Occlusion 2 (SCORE2), National Institutes of Health Data & Safety Monitoring Committee, META-MUST trials, National Institutes of Health Data & Safety Monitoring Board, Stopping Anti-TNF Agents in Rheumatoid Arthritis (STARA), National Institutes of Health and MedStar Health Research Institute Christine C. Nelson, M.D. Best Doctors in America Co-Chair, Oculoplastics Curriculum Development Committee, International Council of Ophthalmology Howard R. Petty, Ph.D. Special Emphasis Panel, Member Conflict: Biology, Pathophysiology and Diseases of the Visual System (ZRG1BDCN-L 02M), National Institutes of Health Special Emphasis Panel, Ocular Diseases Pathophysiology and Therapeutic

Approaches (ZRG1BDCN-R 5M ),

National Institutes of Health

Grant Review Panel, France Ministry of Health

Julia E. Richards, Ph.D. Editorial Board, G3: Genes, Genomes, Genetics Scientific Advisory Board, The Glaucoma Foundation Scientific Reviewer, International Retina Research Foundation Dr. Douglas H. Johnson Award in National Glaucoma Research, Bright Focus Foundation Frank W. Rozsa, Ph.D. Communicators Award, Association for Research in Vision and Ophthalmology Roni M. Shtein, M.D., M.S. Best Doctors in America Medical Advisory Board, Eye Bank Association of America Medical Director, Eversight Michigan Methodologist, Cornea & Anterior Segment Disorders Panel, Ophthalmic Technology Assessment Committees, American Academy of Ophthalmology Methodologist, Refractive Management/Intervention Panel, Terry J. Smith, M.D. Best Doctors in America Michael W. Smith-Wheelock, M.D. Best Doctors in America H. Kaz Soong, M.D. Best Doctors in America Medical Director, Eversight Michigan Joshua D. Stein, M.D., M.S. Best Doctors in America Leadership Development Program XVIII, class of 2016, American Academy of Ophthalmology Academy Standing Committee on Eye Care and Ear, Nose, and Throat Conditions, National Quality Forum Shaffer Grants for Innovative Research, Glaucoma Research Foundation 22nd Annual Roger P. Mason, Sr., M.D. Lecture, Howard University, Washington D.C.

32

FACULTY HONORS AND RECOGNITION

Alan Sugar, M.D.

JULY 1, 2014 — SEPTEMBER 30, 2015

UNIVERSITY OF MICHIGAN AWARDS

Best Doctors in America Editor-in-Chief, Cornea, Journal of the Cornea Society

David A. Antonetti, Ph.D

Medical Director, Eversight Michigan

B-EYE Challenge Award, University of Michigan Biointerfaces Institute

Medical Advisory Board, Eye Bank Association of America Research Committee, Eye Bank Association of America

Cagri G. Besirli, M.D., Ph.D.

Frank Polack, M.D., Memorial Lecture in Cornea, University of Florida

University of Michigan Coulter Translational Research Program Award

Debra A. Thompson, Ph.D.

for Life Sciences Program Kickstart Award

Editorial Board, Experimental Eye Research

University of Michigan Translational Research and Commercialization

Brenda L. Bohnsack, M.D., Ph.D.

Susan S. Thoms, M.D.

Helmut F. Stern Career Development Professor of Ophthalmology

Best Doctors in America

and Visual Sciences

Jonathan D. Trobe, M.D.

Hakan Demirci, M.D.

Best Doctors in America

B-EYE Challenge Award, University of Michigan Biointerfaces Institute

Castle Connolly Top Doctors Arthur Wolintz Memorial Lecture, Department of Ophthalmology, State University of New York (SUNY) Downstate Medical Center Philip C. Hessburg Lecture, 2015 Annual Alumni Meeting, Department of Ophthalmology, Henry Ford Hospital A.E. Finley Distinguished Visiting Professor, Department of Ophthalmology, University of North Carolina Joshua P. Vrabec, M.D. Best Doctors in America Sara Weidmayer, O.D. Admittance Committee, American Academy of Optometry Jennifer S. Weizer, M.D. Best Doctors in America Kwoon Y. Wong, Ph.D. Editorial Board, Current Eye Research Grant Reviewer, Velux Foundations Special Emphasis Panel, Molecular and Cellular Substrates of Complex Brain Disorders [ZRG1 MDCN-P 57], National Institutes of Health Special Emphasis Panel, Neurobiology of Visual Perception and Decision Making [ZRG1 IFCN-Q 02]], National Institutes of Health Maria A. Woodward, M.D. Medical Director, Eversight Michigan Achievement Award, American Academy of Ophthalmology Dongli Yang, M.D., Ph.D. Editorial Board, Austin Journal of Clinical Ophthalmology David N. Zacks, M.D., Ph.D. Best Doctors in America Achievement Award, American Academy of Ophthalmology

Thomas W. Gardner, M.D., M.S. Senior Scholar at the University of Michigan A. Alfred Taubman Medical Research Institute K. Thiran Jayasundera, M.D. University of Michigan Translational Research and Commercialization for Life Sciences Program Award Shahzad I. Mian, M.D. Gilbert Whitaker Fund for the Improvement of Teaching, University of Michigan Center for Research on Learning and Teaching Paula Anne Newman-Casey, M.D., M.S. Community Service Award, University of Michigan Medical School Howard R. Petty, Ph.D. University of Michigan Translational Research and Commercialization for Life Sciences Program Award Rajesh C. Rao, M.D. Leslie H. and Abigail S. Wexner Emerging Scholar at the University of Michigan A. Alfred Taubman Medical Research Institute University of Michigan Biointerfaces Institute Award Joshua D. Stein, M.D., M.S. Edward T. and Ellen K. Dryer Career Development Professor in Ophthalmology and Visual Sciences Alan Sugar, M.D. League of Clinical Excellence, University of Michigan Medical School Maria A. Woodward, M.D. Project Award, University of Michigan Health System Fostering Innovations Grants (FIGS) Program

33

FACULTY PUBLICATIONS JULY 1, 2014 — SEPTEMBER 30, 2015

Airik R, Slaats GG, Guo Z, Weiss AC,

Bainbridge JW...Thompson DA...Ali RR, et al.

Boynton GE, Raoof D, Niziol LM, Hussain M,

Khan N, Ghosh A, Hurd TW, Bekker-Jensen S,

Long-term effect of gene therapy on Leber's

Mian SI. Prospective randomized trial compar-

Schroder JM, Elledge SJ, Andersen JS, Kispert

congenital amaurosis. N Engl J Med. 2015

ing efficacy of topical loteprednol etabonate

A, Castelli M, Boletta A, Giles RH, Hildebrandt

May;372(20):1887-97.

0.5% versus cyclosporine-a 0.05% for treat-

F. Renal-retinal ciliopathy gene Sdccag8 regu-

ment of dry eye syndrome following hemato-

lates DNA damage response signaling. J Am

Bansal S, Balakrishnan SA, Blachley T, Weizer

poietic stem cell transplantation. Cornea. 2015

Soc Nephrol. 2014 Nov;25(11):2573-83.

JS, Lee PP, Stein JD. Subsequent receipt of

Jul;34(7):725-32.

interventions for glaucoma among a nationAlapati AN, Goetz K, Suk J, Navani M,

wide sample of patients who underwent laser

Boynton GE, Stem MS, Kwark L, Jackson

Al-Tarouti A, Jayasundera KT, Lee P, Tumminia

peripheral iridotomy. Am J Ophthalmol. 2015

GR, Farsiu S, Gardner TW. Multimodal

SJ, Ayyagari R. Molecular diagnostic testing

Aug;160(2):275-82.

characterization of proliferative diabetic

by eyeGENE(R). Analysis of patients with he-

retinopathy reveals alterations in outer retinal

reditary retinal dystrophy phenotype involving

Bashshur RL, Shannon GW, Smith BR,

function and structure. Ophthalmology. 2015

central vision loss. Invest Ophthalmol Vis Sci.

Woodward MA. The empirical evidence

May;122(5):957-67.

2014 Jul;55(9):5510-21.

for the telemedicine intervention in diabetes

Apkarian AO, Hervey-Jumper SL, Trobe JD.

management. Telemed J E Health. 2015

Boynton GE, Woodward MA. Evolving tech-

May;21(5):321-54.

niques in corneal transplantation. Curr Surg

Cerebrospinal fluid leak presenting as oculor-

Rep. 2015 Feb;3(2).

rhea after blunt orbitocranial tauma. J Neur-

Bavinger JC, DeLoss K, Mian SI. Scleral lens

oophthalmol. 2014 Sep;34(3):271-3.

use in dry eye syndrome. Curr Opin Ophthal-

Boynton GE, Woodward MA. Eye-bank

mol. 2015 Jul;26(4):319-24.

preparation of endothelial tissue. Curr Opin

Argento A, Kim W, Rozsa FW, DeBolt KL,

Ophthalmol. 2014 Jul;25(4):319-24.

Zikanova S, Richards JR. Shear behavior of

Bennett JL, O'Connor KC, Bar-Or A, Zamvil

bovine scleral tissue. J Biomech Eng. 2014

SS, Hemmer B, Tedder TF, von Budingen HC,

Breker DA, Little AA, Trobe JD. Autoim-

Jul;136(7).

Stuve O, Yeaman MR, Smith TJ, Stadelmann

mune acquired rippling muscle disease and

C. B lymphocytes in neuromyelitis optica.

myasthenia gravis. J Neuroophthalmol. 2014

Arora KS, Robin AL, Corcoran KJ, Corcoran

Neurol Neuroimmunol Neuroinflamm. 2015

Mar;35(1):98-9.

SL, Ramulu PY. Use of various glaucoma surger-

May;2(3):e104.

ies and procedures in Medicare beneficiaries

Breker DA, Stacey AW, Srinivasan A, Bursztyn

from 1994 to 2012. Ophthalmology. 2015

Boss JD, Shah CT, Elner VM, Hassan AS.

LL, Trobe JD, Johnson MW. Vision loss caused

Aug;122(8):1615-24.

Assessment of office-based practice patterns on

by retinal and lateral geniculate nucleus infarc-

protective eyewear counseling for patients with

tion in H1N1 influenza. J Neuroophthalmol.

Atkins SJ, Lentz SI, Fernando R, Smith TJ.

monocular vision. Ophthal Plast Reconstr Surg.

2015 Sep;35(3):265-9.

Disrupted TSH receptor expression in female

2015 Sep-Oct;31(5):361-3.

mouse lung fibroblasts alters subcellular IGF-1

BriceĂąo CA, Zhang-Nunes SX, Massry GG.

receptor distribution. Endocrinology. 2015

Boyer DS, Goldbaum M, Leys AM, Starita C,

Minimally invasive surgical adjuncts to upper

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blepharoplasty. Facial Plast Surg Clin North

tanib sodium 0.3 mg intravitreal injections

Am. 2015 May;23(2):137-51.

Bailey JN...Lichter PR...Moroi SE, Richards

(Macugen) in intraocular pressure: posthoc

JE, et al. Hypothesis-independent pathway

analysis from V.I.S.I.O.N. study. Br J Ophthal-

Brown JC, Goldstein JE, Chan TL, Massof R,

analysis implicates GABA and Acetyl-CoA me-

mol. 2014 Nov;98(11):1543-6.

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tabolism in primary open-angle glaucoma and

Group: Day SH, Wicker DM. Characterizing

normal-pressure glaucoma. Hum Genet. 2014

functional complaints in patients seeking out-

Oct;133(10):1319-30.

patient low-vision services in the United States.

Ophthalmology. 2014 Aug;121(8):1655-62 e1651.

34

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Chan TL, Perlmutter MS, Andrews M, Sun-

Coit P, De Lott LB, Nan B, Elner VM, Sawalha

de Melo Franco R, Kron-Gray MM, De la

ness JS, Goldstein JE, Massof RW, Low Vision

AH. DNA methylation analysis of the temporal

Parra-Colin P, He Y, Musch DC, Mian SI, Niziol

Research Network Study Group: Day SH,

artery microenvironment in giant cell arteritis.

L, Soong HK. Outcomes of cataract surgery

Wicker DM. Equating visual function scales

Ann Rheum Dis. 2015 Jun 2. [Epub ahead

in graft-versus-host disease. Cornea. 2015

to facilitate reporting of medicare functional

of print]

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vision patients. Arch Phys Med Rehabil. 2015

Cornblath WT. Diplopia due to ocular motor

Demirci H, Cullen A, Sundstrom JM.

Jul 9. [Epub ahead of print]

cranial neuropathies. Continuum (Minneap

Enhanced depth imaging optical coherence

Minn). 2014 Aug;20(4):966-80.

tomography of choroidal metastasis. Retina.

g-code severity/complexity modifiers for low-

Chaudhary N, Griauzde J, Gemmete JJ,

2014 Jul;34(7):1354-9.

Pandey AS, Trobe JD. Issues in the diagnosis

Daniel E, Quinn GE, Hildebrand PL, Ells A,

and management of the papilledema shunt.

Hubbard GB, 3rd, Capone A, Jr., Martin ER,

Demirci H, Elner VM. Contemplating the

J Neuroophthalmol. 2014 Sep;34(3):259-63.

Ostroff CP, Smith E, Pistilli M, Ying GS,

diagnostic certainty of primary iris mucosa-

e-ROP Cooperative Group: Musch DC.

associated lymphoid tissue Lymphoma-Reply.

Chen H, Mester T, Raychaudhuri N, Kauh

Validated system for centralized grading of

JAMA Ophthalmol. 2015 Aug 1. [Epub ahead

CY, Gupta S, Smith TJ, Douglas RS. Tepro-

retinopathy of prematurity: telemedicine ap-

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proaches to evaluating acute-phase retinopathy

antibody inhibits TSH and IGF-1 action in

of prematurity (e-ROP) study. JAMA Ophthal-

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fibrocytes. J Clin Endocrinol Metab. 2014

mol. Jun 2015;133(6):675-82.

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Ophthalmol. 2015 Jan;133(1):104-5.

Davis RL, Eiden SB, Bennett ES, Koffler B,

Chen H, Shan SJ, Mester T, Wei YH, Douglas

Wohl L, Lipson M. Stabilizing myopia by

Demirci H, Saponara F, Khan A, Niziol LM,

RS. TSH-mediated TNFalpha production in

accelerating reshaping technique (SMART)-

Lee C, Hayman JA, Comer G, Musch DC.

human fibrocytes is inhibited by teprotumumab,

study three year outcomes and overview. Adv

Regression rate of posterior uveal melanomas

an IGF-1R antagonist. PLoS One. 2015

Ophthalmol Vis Syst. 2015 Apr;2(3):00046.

following iodine-125 plaque radiotherapy.

June;10(6):e0130322.

Middle East Afr J Ophthalmol. 2015 JanDe la Parra-Colin PD, Barrientos-Gutierrez T,

Mar;22(1):103-7.

Chou CM, Nelson C, TarlĂŠ SA, Pribila JT,

Mian SI. Axial length's role in intraocular lens

Bardakjian T, Woods S, Schneider A, Glaser

power calculation error in x-linked megalocor-

Demirci H, Steen DW. Limitations in imaging

T. Biochemical basis for dominant inheritance,

nea: a case-series analysis. Ophthalmic Genet.

common conjunctival and corneal pathologies

variable penetrance, and maternal effects in

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RBP4 congenital eye disease. Cell. 2015 Apr 23;161(3):634-46.

raphy. Middle East Afr J Ophthalmol. 2014 DeLoss KS, Fatteh NH, Hood CT. Prosthetic

Jul-Sep;21(3):220-4.

replacement of the ocular surface ecosystem Choudhry N, Rao RC. Enhanced depth imag-

(PROSE) scleral device compared to kerato-

Demirci H, Worden F, Nelson CC, Elner VM,

ing features of a choroidal macrovessel. Retin

plasty for the treatment of corneal ectasia.

Kahana A. Efficacy of vismodegib (erivedge)

Cases Brief Rep. 2015 May 29. [Epub ahead

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2015 May;133(5):605-6.

1 is necessary for hyperglycemia-induced vascular endothelial growth factor expression in the retina of diabetic rodents. J Biol Chem.

2015 Feb 6;290(6):3865-74.

35

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Dlouhy BJ, Awe O, Rao RC, Kirby PA, Hitchon

Fernando R, Lu Y, Atkins SJ, Mester T,

Garnai SJ, Huyghe JR, Reed DM, Scott KM,

PW. Autograft-derived spinal cord mass follow-

Branham K, Smith TJ. Expression of thyro-

Liebmann JM, Boehnke M, Richards JE, Ritch

ing olfactory mucosal cell transplantation in a

tropin receptor, thyroglobulin, sodium-iodide

R, Pawar H. Congenital cataracts: de novo

spinal cord injury patient. J Neurosurg Spine.

symporter, and thyroperoxidase by fibrocytes

gene conversion event in CRYBB2. Molecular

2014 Oct;21(4):618-22.

depends on AIRE. J Clin Endocrinol Metab.

Vision. 2014 Nov;20:1579-93.

2014 Jul;99(7):E1236-44.

Du Y, Cramer M, Lee CA, Tang J, Muthusamy A, Antonetti DA, Jin H, Palczewski K, Kern

Ghodasra DH, Demirci H. Photodynamic Fort PE, Darche M, Sahel JA, Rendon A,

therapy for choroidal metastasis. Am Ophthal-

TS. Adrenergic and serotonin receptors affect

Tadayoni R. Lack of dystrophin protein Dp71

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retinal superoxide generation in diabetic mice:

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to loss of fiber cell organization. Molecular

Goldstein JE, Jackson ML, Fox SM, Deremeik

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JT, Massof RW, Low Vision Research Network

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Study Group: Day SH, Wicker DM. Clinically Fort PE, Losiewicz MK, Pennathur S, Jefferson

meaningful rehabilitation outcomes of low vi-

Dulle JE, Fort PE. Crystallins and neuroinflam-

LS, Kimball SR, Abcouwer SF, Gardner TW.

sion patients served by outpatient clinical cen-

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the developing and adult retina of the zebrafish

Jeffrey BG, Heckenlively JR, Reddy GB, Lee P,

M, Arnold CR, Gage PJ, Skarie JM, Dobyns

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WB, Millen KJ, Liu T, Dietz W, Kume T, Hofker

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36

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He Y, de Melo Franco R, Kron-Gray MM,

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Katz DM, Trobe JD. Is there treatment for

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Woodward MA, DeLoss K, Mian SI. Long-term

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use of autologous serum 50% eye drops for the

Khan M, Walters LL, Li Q, Thomas DG, Miller

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37

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Lagina A. Don't forget contact lenses in ocular

Lichter PR. Payment data and the "me"

Marshall J, Wong KY, Rupasinghe CN, Tiwari

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42

EXTERNAL GRANTS AND FUNDING

JULY 1, 2014 — SEPTEMBER 30, 2015

FA CU LTY NA M E

P ROJ EC T T IT L E

SO UR C E

S. Abcouwer, Ph.D.

Bone Marrow Neuropathy Drives Diabetic Retinopathy; multi-PI

NIH

Regulation of Retinal Cell Death in Diabetes; multi-PI

NIH

Role of Interferon-gamma in the Retinal Neuroinflammatory

ADA

Control of Innate Inflammatory Responses in the Retina; multi-PI

BrightFocus Foundation

CCL2 Trap for Diabetic Retinopathy; multi-PI

Novo Nordisk

D. Antonetti, Ph.D.

Mechanisms of Retinal Vascular Permeability in Diabetes

NIH

The Retinal Microenvironment in Diabetic Retinopathy,

NIH

Subcontract with Northwestern University

Novel Therapies to Inhibit Diabetic Retinopathy,

NIH

Subcontract with Case Western University

Discovering Novel Atypical PKC Inhibitors as in vivo Chemical Probes

NIH

Structural Studies of Tight Junction Proteins,

NIH

Subcontract with Pennsylvania State University

Targeting aPKC as a Therapy for Diabetic Retinopathy

JDRF

CCL2 Trap for Diabetic Retinopathy; multi-PI

Novo Nordisk

Jules and Doris Stein RPB Professorship

RPB

S. Archer, M.D.

Ocular Toxicity of Combined Carboplatin and Etoposide Phosphate Intravitreal

The Knights Templar

C. Besirli, M.D., Ph.D.

Injection Therapy (IViT) for Retinoblastoma, Award for Stephen Smith, M.D.

Neuroprotection in Pediatric Retinal Detachment

Foundation, Inc.

NIH

Cryoanesthesia

MEDC

Testing of ONL Compounds in Retinal Cell Apoptosis Models

ONL Therapeutics

Career Development Award

RPB

B. Bohnsack, M.D., Ph.D.

Regulation of Ocular Neural Crest and Its Implications in Congenital Eye Diseases

NIH

Zebrafish Model of Primary Congenital Glaucoma: Understanding CYP1B1

Edward Mallinckrodt Jr. Foundation

Regulation of Eye Development

Career Development Award

RPB

G. Comer, M.D., M.S.

Treatment for Central-Involved Diabetic Macular Edema in Eyes,

NIH/Clinical Trial

Coordinating Center: Jaeb Center for Health Research

Structural and Functional Relationships of the Retina in Diabetic Macular Edema

JDRF

A Natural History Study of Macular Telangiectasia—The MacTel Study

LMRI/Clinical Trial

A Phase 2 Multicenter Randomized Clinical Trial of Ciliary Neurotrophic

LMRI/Clinical Trial

W. Cornblath, M.D.

A Randomized, Placebo-Controlled, Parallel-Group, Double-Blind Efficacy

M. Del Monte, M.D.

Factor (CNTF) for Macular Telangiectasia Type 2 (MacTel)

A 3-month, Multi-Center, Double-Masked Safety and Efficacy Study of

Travoprost Ophthalmic Solution, 0.004% Compared to Timolol

(0.5% or 0.25%) in Pediatric Glaucoma Patient

Merck Research Labs

& Safety Trial of MK-8931 in Subjects with Mild to Moderate Alzheimer's Disease

Study of Binocular Computer Activities for Treatment of Amblyopia

Alcon Laboratories, Inc.

JAEB Center/NIH/Clinical Trial

43

EXTERNAL GRANTS AND FUNDING

JULY 1, 2014 — SEPTEMBER 30, 2015

FA CU LTY NA M E

P ROJ EC T T IT L E

SO UR C E

R. Douglas, M.D., Ph.D.

Role of CD40+ Fibrocytes in Thyroid-Associated Ophthalmopathy

NIH

A Multicenter, Double-Masked, Placebo-Controlled Efficacy and Safety Study

River Vision LLC

of RV001, an Insulin-like Growth Factor-1Receptor (IGF-1R) Antagonist

Antibody (fully human), Administered Every 3 Weeks (Q3W) by Intravenous

(IV) Infusion in Patients Suffering from Active Thyroid Eye Disease (TED)

Lew R. Wasserman Merit Award

RPB

S. Elner, M.D.

Multicenter Uveitis Steroid Treatment (MUST) Trial,

NIH/Clinical Trial

Coordinating Center: Johns Hopkins University

Macular Edema Treatment Trials Associated with MUST (META-MUST)

NIH/Clinical Trial

Intravitreal Injections of DE-109 for the Treatment of Active, Non-Infectious Uveitis

Santen Pharmaceutical

P. Fort, Ph.D., M.S.

Progressive Impact of Diabetes on Retinal Neuroprotection by α-Crystallins NIH

Characterization of Crystallin Proteins Expression in Human Retina: Effect

Regulation of Crystallin Neuroprotective Function in the Retina During

Eversight

of Diabetes Diabetes: Impact on Retinal Ganglion Cell Death

International Retinal Research Foundation

P. Gage, Ph.D.

Pitx 2: Molecular Mechanisms in Eye Development and Disease

NIH

An Inducible and Rapid Model of Glaucoma in Mice

BrightFocus Foundation

Analysis of Ocular Functions of CHD7 in Mouse Models of CHARGE

CHARGE Syndrome Foundation, Inc.

New Mouse Models of Human CHARGE Syndrome

Eversight

T. Gardner, M.D., M.S.

Metabolic Reprogramming in Diabetic Complications; multi-PI

NIH

Michigan Vision Clinician-Scientist Development Program; multi-PI

NIH

Regulation of Retinal Cell Death in Diabetes; multi-PI

NIH

Genes in Diabetic Retinopathy, Coordinating Center: Jaeb

NIH/Clinical Trial

Prompt Panretinal Photocoagulation (Protocol S), Coordinating Center: Jaeb

NIH/Clinical Trial

Clinical Research Training in Diabetic Macular Edema,

Bayer HealthCare

Award with Vinicius Monteiro de Castro, M.D., Ph.D.

A Diabetic Retinopathy Risk of Progression Calculator

Eversight

Evaluation of Retinal Sensory Neuropathy

JDRF

Diabetic Complications Scientific Challenge

Novo Nordisk

Physician-Scientist Award

RPB

J. Heckenlively, M.D.

Investigation of Autoimmune Anti-Retinal Antibodies in Diabetes

NIH

Center for the Study of Retinal Degenerative Diseases

FFB

Clinical Evaluation of Individuals with X-linked Retinoschisis (XLRS)

FFB and Applied Genetic

A Phase II, Multiple-Site, Randomized, Placebo-Controlled Trial of Oral Valproic

44

NNRI

Acid for Retinitis Pigmentosa

Retinitis Pigmentosa Natural History Study of Patients with the P23H Mutation

Technologies Corp.

of the Rhodopsin Gene

The EMMES Corporation

EXTERNAL GRANTS AND FUNDING

JULY 1, 2014 — SEPTEMBER 30, 2015

FA CU LTY NA M E

P ROJ EC T T IT L E

SO UR C E

P. Hitchcock, Ph.D.

Neuronal Development, Injury and Repair in Retina

NIH

Vision Research Training Program

NIH

B. Hughes, Ph.D.

Core Center for Vision Research (five core modules)

NIH

Ion Conductances in the Retinal Pigment Epithelium

NIH

K.T. Jayasundera, M.D.

Novel Quantification Methods for Fundus Flavoprotein Fluorescence

Eversight

and Lipofuscin Fluorescence to Detect Progression in Stargardt Disease

EyeAnalyze: Automated Identification and Quantification of Changes in

MEDC

Retinal Diseases

Post-Approval Study of the Argus II Retinal Prosthesis System

Second Sight Medical Products, Inc

M. Johnson, M.D.

Efficacy and Safety of Lampalizumab Administered Intravitreally to Patients

Genentech, Inc.

with Geographic Atrophy Secondary to Age-Related Macular Degeneration

A. Kahana, M.D., Ph.D.

A Zebrafish Model of Extraocular Muscle Regeneration

NIH

Investigating the Roles of Retinoic Acid and Thyroid Hormone in the Pathogenesis

Alliance for Vision Research

of Thyroid Eye Disease

VISmodegib as Neo-adjuvant for ORBital and Periocular Basal Cell Carcinoma

(VISORB)

Genentech, Inc./Clinical Trial RPB

Physician-Scientist Award

P. Lee, M.D., J.D.

Michigan Vision Clinician-Scientist Development Program; multi-PI

NIH

Vision Health Initiative - IPA with CDC

NIH

Unrestricted Grant

RPB

Child Vision Care Fund

W.K. Kellogg Foundation

M. Lipson, O.D.

Overnight Corneal Reshaping - Quality of Life (OCRQL) Survey Instrument

Bausch & Lomb, Inc.

S. Mian, M.D.

Eye Bank Preparation of Donor Tissue for Descemet’s Membrane

Eversight

Endothelial Keratoplasty

In vivo Assessment of a Novel Intraocular Pressure Transducer

MEDC

A Prospective, Multicenter, Post-Approval Study of Vision Care’s Implantable

VisionCare Ophthalmic

Miniature Telescope (by Dr. Isaac Lipshitz) in Patients with Bilateral Severe to

Profound Central Vision Impairment Associated with End-Stage Age-Related

Macular Degeneration

S. Moroi, M.D., Ph.D.

Aqueous Humor Dynamic Components that Determine Intraocular

D. Musch, Ph.D., M.P.H.

Allergan Pharmaceuticals, Inc./

or Ocular Hypertension

Factors Predictive of Rapid Visual Field Loss in Early Glaucoma,

NIH

Pressure Variance

The Efficacy and Safety of Bimatoprost SR in Patients with Open-Angle Glaucoma

Technologies, Ltd.

Clinical Trial

NIH

Subcontract with Washington University

Statins to Prevent Glaucoma Trial (STOP Glaucoma Trial) Planning Grant; multi-PI

NIH

Assessing the Impact of Glaucoma and Its Treatment on the Person

NIH

45

EXTERNAL GRANTS AND FUNDING FA CU LTY NA M E

JULY 1, 2014 — SEPTEMBER 30, 2015

P ROJ EC T T IT L E

SO UR C E

P. Newman-Casey, M.D., M.S. Adherence to Glaucoma Medications

Allergan Pharmaceuticals, Inc.

H. Petty, Ph.D.

Nanoparticle Therapy in Cancer

MEDC

D. Puro, M.D., Ph.D.

Retinovascular Pathophysiology: Focus on Proliferative Retinopathy

NIH

R. Rao, M.D.

Sustaining Early-Born Retinal Neuron Potency from Stem Cells:

RPB

An Epigenetic Approach

Targeting EZH2, a Histone Methyltransferase, as a Novel Therapy for

The Knights Templar

Human Retinoblastoma

Foundation, Inc.

J. Richards, Ph.D.

Genetics of Homocycteine Metabolism in Glaucoma

BrightFocus Foundation

A Study of Ocular Aging

Eversight

Mechanics of Intraocular Pressure Increase Associated with

NSF

R. Shtein, M.D., M.S.

Multinational, Collaborative Evaluation of Corneal Confocal Microscopy

Diabetic Neuropathy in Type 1 Diabetes; multi-PI,

Subcontract with Mount Sinai Hospital

Assessment of Dry Eye Symptom Severity (DREAM study),

NIH

Subcontract with University of Pennsylvania

Trends in Utilization of Endothelial and Penetrating Keratoplasty for

NIH

as a Surrogate Endpoint for the Identification and Prediction of

Eversight

Treatment of Corneal Endothelial Disease

In vivo Effects of Antiglaucomatous Prostaglandin Therapy on Immune Cells,

Epithelium, and Nerves of the Ocular Surface: A Laser in vivo Confocal

Microscopy Study

MEEI

T. Smith, M.D.

Regulation of Retroocular Connective Tissue

NIH

UM-ACE: ACE Collaborative Project,

NIH

Subaccount with David A. Fox, M.D., Department of Internal Medicine,

University of Michigan

Physician-Scientist Award

RPB

J. Stein, M.D., M.S.

Statins to Prevent Glaucoma Trial (STOP Glaucoma Trial)

NIH

Collaboration on Cost-Effectiveness Analyses--DRCR Network,

NIH

Subcontract with JAEB Center for Health Research

Workforce Assessment of Eye Care Providers

American Academy of Ophthalmology

Impact of Losartan Use on the Risk of Developing Open-Angle Glaucoma

American Glaucoma Society

A Dynamic, Personalized Glaucoma Monitoring Decision Support

Glaucoma Research Foundation

Model Enabled by an Extension of Kalman Filtering Theory

Assessment of the Relation between Medications for Epilepsy and Risk of

46

Genetic Factors; multi-PI

Developing Open-Angle Glaucoma

Harvard University

EXTERNAL GRANTS AND FUNDING FA CU LTY NA M E

JULY 1, 2014 — SEPTEMBER 30, 2015

P ROJ EC T T IT L E

SO UR C E

J. Stein, M.D., M.S. (cont.) Do Patients with Vision Loss Use More Healthcare Services

Lighthouse Guild

MEEI

Assessment of the Relation between Medications that Alter Innate Immunity

and Glaucoma

Physician-Scientist Award

RPB

The Epidemiology of Macular Holes and whether Use of Medication

University of California

Containing Estrogen Affect Development of Macular Holes

Are Medications Used to Treat HIV and Hepatitis Beneficial in Preventing

San Francisco

University of Kentucky

Macular Degeneration

A. Sugar, M.D.

Corneal Preservation Time Study, Coordinating Center: Jaeb

NIH/Clinical Trial

D. Thompson, Ph.D.

Control of Innate Inflammatory Responses in the Retina; multi-PI

BrightFocus Foundation

Center for the Study of Retinal Degenerative Diseases

FFB

Gene-Replacement Therapy for XLRP Due to RPGR Mutations

FFB

Gene-Replacement Therapy for RDH12 Mutations

RDH12 Fund for Sight

J. Trobe, M.D.

Automated Diplopia Assessment System (ADAS); multi-PI,

Medar Corporation/Michigan

Award with Lindsey De Lott, M.D.

Corporate Relations Network

K. Wong, Ph.D.

Physiology of Intrinsically Photosensitive Rentinal Ganglion Cells

NIH

Ameliorating the Condition of the Blind through Melanopsin

Alliance for Vision Research

Neural Circuits and Synapses for Early Visual Processing

US Department of Defense-Army

M. Woodward, M.D.

Telemedicine For Anterior Eye Diseases

NIH

D. Zacks, M.D., Ph.D.

Autophagy and Control of Photoreceptor Apoptosis

NIH

Autophagy and Control of Photoreceptor Cell Death in Autosomal Dominant

Bayer HealthCare

Retinitis Pigmentosa

Center for the Study of Retinal Degenerative Diseases

FFB

Dysregulaton of RPE Autophagy and Age-related Macular Degeneration

RPB

SOURCE ABBREVIATIONS ADA ...... American Diabetes Association

NIH ....... National Institutes of Health

FFB ....... Foundation Fighting Blindness

NNRI ..... National Neurovision Research Institute

JDRF ..... Juvenile Diabetes Research Foundation International

NSF ....... National Science Foundation

MEEI ..... Massachusetts Eye and Ear Infirmary

RPB ....... Research to Prevent Blindness

MEDC .... Michigan Economic Development Corporation

47

W.K. KELLOGG EYE CENTER FACULTY, FELLOWS, AND RESIDENTS 2015

All of us at the Kellogg Eye Center are committed to improving lives through curing, preventing, and treating eye disease.

Faculty of the Department of Ophthalmology and Visual Sciences First row (left to right): Sejal Amin, M.D., Melisa Nika, M.D., Courtney Kauh, M.D., M.S., Paul Lichter, M.D., M.S., Michael Smith-Wheelock, M.D., H. Kaz Soong, M.D., Alan Sugar, M.D., Monte Del Monte, M.D., Paul Lee, M.D., J.D., Christine Nelson, M.D., Denise John, M.D., Mark Johnson, M.D., Shahzad Mian, M.D., Thomas Gardner, M.D., M.S., Donna Wicker, O.D., Dolly Padovani-Claudio, M.D., Ph.D., Shannon Joseph, M.D. Second row (left to right): Joshua Stein, M.D., M.S., Matthew Manry, M.D., Rajesh Rao, M.D., Anjali Shah, M.D., Paula Anne Newman-Casey, M.D., M.S., Gale Oren, M.I.L.S., Kari Branham, M.S., Naheed Khan, Ph.D., Dongli Yang, M.D., Ph.D., Kwoon Wong, Ph.D., Patrice Fort, Ph.D., M.S., David Musch, Ph.D., M.P.H., Alon Kahana, M.D., Ph.D., César Briceño, M.D., Cagri Besirli, M.D., Ph.D., Stephen Smith, M.D., Grace Wang, M.D., Ph.D., Catherine Choi, M.D., Sophia Wang, M.D., Marina Eisenberg, M.D., Fatemeh Rajaii, M.D., Ph.D. Third row (left to right): Karen Christopher, M.D., Stephen Odaibo, M.D., Hakan Demirci, M.D., Daniel Kasprick, M.D., Sara Weidmayer, O.D., Zvi Kresch, M.D., Cheng-mao Lin, Ph.D., Roni Shtein, M.D., M.S., Courtney Dewey, O.D., Elizabeth Du, M.D., Abigail Fahim, M.D., Ph.D., Wayne Cornblath, M.D., Amy Lagina, O.D., K. Thiran Jayasundera, M.D., Sherry Day, O.D., Lee Kiang, M.D., Ph.D., Neil Farbman, M.D., J.D., Steven Cohen, M.D. Fourth row (left to right): Angela Elam, M.D., Krista Stewart, M.D., Daniel Albertus, M.D., Shivani Gupta, M.D., Donald Puro, M.D., Ph.D., Bradley Taylor, O.D., M.P.H., Christopher Gappy, M.D., Karen DeLoss, O.D., Susan Elner, M.D., Theresa Cooney, M.D., Joshua Vrabec, M.D., Steven Archer, M.D., Lindsey De Lott, M.D., Rebecca Wu, M.D., Ariane Kaplan, M.D., Monica Michelotti, M.D., Kevin Tozer, M.D., Devon Ghodasra, M.D. Fifth row (left to right): Daniel Sand, M.D., Marius A. Tijunelis, M.D., M.B.A., Terry Smith, M.D., John Heckenlively, M.D., Paul Grenier, O.D., Steven Abcouwer, Ph.D., Terry Bergstrom, M.D., Gary Sandall, M.D., M.S., Bret Hughes, Ph.D., Philip Gage, Ph.D., Grant Comer, M.D., M.S., Jonathan Greene, M.D., Jerome Finkelstein, M.D., Helios Leung, O.D., Ph.D., Andrew Stacey, M.D., M.S., Maxwell Stem, M.D., David DeMill, M.D., Andrew Lewis, M.D., Kristopher Kowal, M.D. For a complete listing of our faculty, visit: www.kellogg.umich.edu/about/faculty_bios.html

Our guiding principles are teamwork, caring, innovation, and integrity.

Executive Officers of the University of Michigan Health System Marschall S. Runge, M.D., Ph.D. Executive Vice President for Medical Affairs and Dean of the Medical School David A. Spahlinger, M.D. Executive Vice Dean for Clinical Affairs and President of the Hospitals, Health Centers, and U-M Medical Group T. Anthony Denton, J.D., M.H.A. Senior Vice President and Chief Operating Officer for the Hospitals, Health Centers, and U-M Medical Group The Regents of the University of Michigan Michael J. Behm, Mark J. Bernstein, Laurence B. Deitch, Shauna Ryder Diggs, Denise Ilitch, Andrea Fischer Newman, Andrew C. Richner, Katherine E. White, Mark S. Schlissel (ex officio) Editor: Jonathan D. Trobe, M.D. Writers: Aimee Bergquist, Barbara Sefton Editorial Assistant: Lisa Burkhart Design and Art Direction: David Murrel Photographers: Eric Bronson, Daryl Marshke, Scott Soderberg, Austin Thomason, Michigan Photography; Amber Schultz, U-M Department of Ophthalmology and Visual Sciences

FOR PATIENT APPOINTMENTS, PLEASE CALL 734.763.8122 For additional copies, please contact us: University of Michigan Department of Ophthalmology and Visual Sciences W.K. Kellogg Eye Center 1000 Wall Street Ann Arbor, Michigan 48105 734.763.4660 • www.kellogg.umich.edu

University of Michigan W.K. Kellogg Eye Center Department of Ophthalmology and Visual Sciences 1000 Wall Street Ann Arbor, MI 48105

Kellogg Among Nation’s Best in Eye Care

10

#

OPHTHALMOLOGY IN THE NATION

The University of Michigan Kellogg Eye Center is proud to be ranked #10 in the country by U.S. News & World Report for being among the nation’s best in providing outstanding care for the most complex eye conditions.

Kellogg has seen extraordinary growth in all aspects of patient care, research and education since the department was established in 1872. Every day, our clinicians, scientists, trainees and staff work together to shape the future of eye care and vision science. The Kellogg team is especially proud of these recent accomplishments: • Kellogg retinal surgeons performed the first four surgeries in the United States to implant an artificial retina, or “bionic eye,” since the FDA approved the device in 2013.

2015 U.S. NEWS & WORLD REPORT’S “BEST HOSPITALS”

•

Kellogg scientists received $14M in research funding in FY 2015, with $6.8M coming from the National Institutes of Health (NIH). This ranks Kellogg #10 in NIH funding among U.S. eye institutions.

•

Kellogg is one of the top eye centers in the world for training the next generation of physician-scientists. In 2015, Doximity ranked Kellogg’s residency program #8 in reputation and #6 in research output.