2013 Annual Report - U-M Kellogg Eye Center by U-M Kellogg Eye Center

2013 Annual Report

UNIVERSITY OF MICHIGAN W.K. KELLOGG EYE CENTER 2 013 ANNUAL REPORT

CURING PREVENTING TREATING

Looking to the Future of Ophthalmology University of Michigan Kellogg Eye Center Annual Report 2013

Perspectives on the Future of Ophthalmology

Sharing Wisdom on a Global Basis

Discovering New Therapies for Eye Disease

2 Moving towards curing,

8 Developing low vision and

16 Regenerating cells to restore

8 Sharing insights on quality

19 Investigating the potential

9 Leveraging efficiencies at the

20 Testing a new treatment

4 Personalizing care for patients with chronic eye diseases

Developing the Foundations for Tomorrow’s Breakthroughs

Providing the Means to Shape the Future

6 Using telemedicine to bring

10 Supporting high-risk, high-

23 Fostering a learning

treating, and preventing eye disease

Meeting the Need for Eye Care in the Era of Population Health

eye care to patients where they live

7 Improving our quality on

a continuous basis

*This report covers the period July 1, 2012, through June 30, 2013

contact lens expertise in Taiwan

of care

Aravind Eye Care System

reward, early-stage research

12 Creating “audacious” goals

for vision research

13 Nurturing tomorrow’s leaders 14 Studying mechanisms of

vision and disease

function

for reprogramming cells

for Graves’ eye disease

environment for tomorrow’s leaders

24 Gathering leaders at a

symposium on gene and stem-cell based therapies for retinal disease

26 Inaugurating the Frueh Professorship

Front cover: Top row: Ryan Fante, M.D., Stephanie Chu, M.D., Jennifer Weizer, M.D. Bottom row: Maho Shibata, M.D., Ph.D., Jason Miller, M.D., Ph.D. Back cover: Top row: Lindsey De Lott, M.D., Philip Gage, Ph.D. Bottom row: Julia Richards, Ph.D., Rajesh Rao, M.D.

Kellogg’s leadership team: Paul Lee, M.D., J.D., Thomas Gardner, M.D., M.S., Alan Sugar, M.D., Michael Smith-Wheelock, M.D., Shahzad Mian, M.D.

The Chair’s Perspective

Keeping Our Eyes on the Future We are fortunate to be part of the University of Michigan and its Health System, whose leaders place great value on discovery and innovation. Within our Department and across the Michigan campus, forwardlooking thinkers are taking a new look at how we care for our patients, educate our trainees, and accelerate exciting new areas of research. This year’s annual report offers a glimpse at some of the advances we believe will significantly contribute to the future of ophthalmology. Our growing faculty is leading us in new directions with collaborative initiatives in areas such as telemedicine, vision regeneration, delivery models influenced by best practices from around the world, and new training approaches. Applying technology to health care. When we follow traditional models of care focusing on “one size fits all” solutions, we miss opportunities to deliver personalized health strategies to help patients at earlier stages of disease when the payoff may be greater. For 2

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example, the risk of vision loss is high when patients are not able to follow instructions for taking glaucoma medications. To help mitigate this issue, Dr. Paula Anne Newman-Casey, along with colleagues from the School of Public Health, the VA’s Health Services Research Group, the Institute for Health Policy and Innovation, and the College of Pharmacy, is investigating the use of personalized educational technologies to help patients manage their medications over a lifetime. Other faculty, like Drs. Maria Woodward and Lindsey De Lott, see telemedicine as a means to extend the reach of specialty care for patients who live far from medical centers where complex ophthalmic conditions are often treated. With increasing interest in the health of populations as a whole, such approaches will help maintain high quality care for individuals as well as for groups. Encouraging our colleagues to pursue their interests. Our new residency career development awards encourage trainees to initiate and conduct research and academic projects they are passionate about, providing them with the opportunity to be leaders, with support and mentoring from experienced scientists. In this report, we highlight three of the six awardees’ projects: a survey of safety standards established by the United Kingdom’s National Health System, a study of protein changes that occur in various types of macular edema, and an investigation of the feasibility of using the femtosecond laser for glaucoma surgery.

Kellogg also emphasizes training and mentoring for our early career clinician-scientists. Dr. Thomas Gardner led the Department’s effort to obtain a National Eye Institute K12 Training Grant that provides protected research time and mentoring for faculty who wish to develop a major research program in tandem with their practice. In addition to our two K12 faculty, four more Kellogg faculty have received individual NIH clinician-scientist training awards this past year. Our patients will benefit from having doctors who are able to connect their research efforts with patient problems observed in the clinic.

Dr. Robin Ali, noted for his work in gene and cell-based therapies, will become a Visiting Professor at Kellogg, sharing his knowledge with faculty and trainees in our Department. And we continue to cultivate relationships with other leaders from institutions worldwide. Friends of the Eye Center are helping us find new ways to support novel ideas. Many generous donors have contributed to the Paul R. Lichter, M.D., Research Discovery Fund to provide seed funding for innovative, high-risk, high-reward research. This support allows scientists to test potentially revolutionary new ideas and to collect data needed to ultimately translate these ideas into improved patient care. Over the years, our friends have been steadfast supporters of our research program and our Department.

Ophthalmology is a global enterprise. We are learning from colleagues in other countries, while providing unique training opportunities here at Kellogg. A team comprised of members from Kellogg, U-M, Aravind, The patient is the center of our world. Any conand Dr. Alan Robin, the first Visiting Scholar to our cept — from telemedicine to gene therapy — must Center for International Ophthalmology, worked with translate to improved and compassionate care for our U-M medical student Hong-Gam Le to better underpatients. In this report, you can read stand the uniquely efficient process “The future of eye care about Drs. Terry Smith and Raymond for cataract surgeries at the Aravind Douglas’ success in launching a large Eye Hospitals in India. Back in our is full of promise, thanks clinical trial to evaluate a treatment clinics, the Center has arranged for for Graves’ eye disease that is the physicians from other countries to to the shared goals and direct result of their years of research receive training in low vision and speon this autoimmune disorder. Their cialty contact lens care. efforts of our faculty, patients who struggle with this difAdvancing new fields of research. staff, alumni, and friends ficult disease are grateful for their progress. For years, physicians have strived From our vantage point, the for the day we could offer patients of the Eye Center.” future of eye care is full of promise, targeted, customized treatments, such thanks to the shared goals and efforts as gene and stem-cell based thera— Paul P. Lee, M.D., J.D. of our faculty, staff, alumni, and pies. Our scientists are bringing these friends of the Eye Center. Together we are summoning hopes closer to reality, with their progress in regenerathe best of our innovative and sometimes “audacious” tive medicine through the study of eye development thinking to improve lives by curing, treating, and preand eye tissue regeneration. One of our newest faculty venting eye disease. As you read about the achievements members, Dr. Rajesh Rao, is investigating the concept and activities in this report, I hope that you will be of reprogramming cells to repair diseased eye tissue. inspired by the dedication of all who contribute to the And recently, our research faculty met with other leadKellogg Eye Center. ing scientists at an international symposium to discuss strategies for moving advanced therapies for eye disease forward into clinical trials. Collaborating for innovation. New ideas often come from working with colleagues in other disciplines and with other institutions. Our faculty has initiated collaborative projects with a range of programs including engineering, rheumatology, and mathematics.

Paul P. Lee, M.D., J.D. F. Bruce Fralick Professor and Chair Ophthalmology and Visual Sciences Director, W.K. Kellogg Eye Center Innovation in vision

Health Information Technology Helps Personalize Eye Care Dr. Newman-Casey wants to make it easier for every patient to adhere to medication regimens

Paula Anne Newman-Casey, M.D. (third from left) with her mentorship team: Michele Heisler, M.D., M.P.H., Joshua Stein, M.D., M.S., Lawrence An, M.D., Karen Farris, Ph.D., and Paul Lee, M.D., J.D.

into consideration patient perceptions about their “Medications have been shown to stop the progression disease and its treatment. “We want to impact not only to blindness in glaucoma, but their effectiveness is often medication adherence, but also self-efficacy — in helping decreased by poor adherence,” says assistant professor patients to have the confidence to successfully take Paula Anne Newman-Casey, M.D., M.S. “Research has their medication regularly,” says Dr. Newman-Casey. shown that at least 30 percent of glaucoma patients do Dr. Newman-Casey will not adhere to their daily medicollaborate with experts at the cation schedules.” The same “As physicians, we are trying to U-M Center for Health Commuproblem occurs in many chronic convince our patients to do some- nication Research to bring their diseases. expertise into the realm of eye “One of the unique chalthing that disrupts their daily care. “The Center has created a lenges of glaucoma therapy wide range of educational prois that patients do not always routine — all without any immegrams using innovative models know how to properly instill of technology to improve chrondrops into their eyes,” says Dr. diate benefit or gain — so that ic disease management in such Newman-Casey. “Added to this, areas as smoking cessation and most of these medications are ten to twenty years from now diabetes, but these programs are administered on a daily basis, rarely used in ophthalmology,” often twice a day. As physicians, they will still have good vision.” says Dr. Newman-Casey. “Our we are trying to convince our long-term goal is to develop patients to do something that — Paula Anne Newman-Casey, M.D., M.S. additional tools with health disrupts their daily routine — all information technology to improve chronic disease without any immediate benefit or gain — so that ten to management and outcomes in ophthalmology.” twenty years from now they will still have good vision. This is one of the reasons that adherence rates are low. Dr. Newman-Casey joined the Department of OphWe’re talking about long-term benefit, but with a great thalmology and Visual Sciences under the National deal of short-term cost.” Eye Institute K12 Michigan Vision Clinician-Scientist Under a training grant from the National Eye Development Program, an award that provides training Institute, Dr. Newman-Casey plans to create technoland mentorship to young ophthalmologists planning to ogy-based educational programs that could make it develop careers as clinician-scientists. The Department simpler for patients to follow their medication regiis one of only six in the nation to receive this award. mens. Such interventions will be personalized and take

university of michigan kellogg eye center

Helping Patients with neuro-ophthalmic disorders receive the care they need

Dr. De Lott will analyze patterns of care with an eye toward telemedicine solutions One of Kellogg’s newest faculty members wants to improve care for patients with neuro-ophthalmic Dr. Lindsey De Lott’s research will help patients with neuro-ophthalmic conditions. conditions. Lindsey B. De Lott, M.D., who completed On her computer screen is an image of severe papilledema, swelling of the her residency in neurology and a fellowship in neurooptic disc caused by increased intracranial pressure. ophthalmology, has observed that non-specialists are often the first to see patients with neuro-ophthalmic diseases. As such, one of her goals is to help our coldatabases that meticulously detail patient visits to clinics leagues make faster diagnoses and promote appropriate and hospital emergency rooms, Dr. De Lott will analyze testing and care. the number of patient visits, types of providers caring Part of the challenge lies with the complexity of for these patients, diagnoses rendered, testing ordered, these disorders, often the result of neurologic conditions and how these parameters are changing over time. That affecting the visual pathways, such as stroke or trauinformation, along with geographic matic brain injury. Specific disorders data, will allow her to evaluate how are not easy to diagnose, given the ar- Dr. De Lott envisions telecare may differ in certain areas, ray of symptoms, from headache and particularly in regions where there blurred vision to double vision. medicine applications to is little neuro-ophthalmic support. “The situation is further comhelp providers identify The resulting report will provide plicated when patients do not have the basis for developing new proaccess to specialty care,” says grams to aid physicians in the triage, Dr. De Lott. “Neuro-ophthalmologists and treat common neurodiagnosis, and management process. tend to practice in academic medical ophthalmic conditions and Dr. De Lott envisions telemedicine centers or in big cities, which means applications to help providers identhat patients in rural areas or some to improve patient access tify and treat common neuro-ophurban areas may have more difficulty thalmic conditions and to improve receiving advanced care.” to specialty care. patient access to specialty care. Dr. De Lott has been awarded “These kinds of applications a National Institutes of Health T32 could also help us make more effective use of reTraining Grant from the U-M Department of Neusources,” says Dr. De Lott. “But most important, we rology to investigate where patients are first seen for can help patients by providing quality care whether neuro-ophthalmologic conditions and how that affects they live in this country or anywhere in the world.” resource utilization. Drawing on two large national

Innovation in vision

Dr. Maria Woodward shows resident Courtney Kauh, M.D., how to capture photos of the exterior features of eye disease using a portable camera.

The resulting image of the eye could be sent electronically to a physician in another location.

Telemedicine to Extend Eye Care in the Era of Information Technology Patients who lack access to health care will benefit most from new technologies a geographically distant clinic and a physician, with Over the next five years, cornea specialist Maria A. images and other data sent via telecommunication Woodward, M.D., will investigate how telemedicine technology. Given the growing number of people with can be used to extend affordable and accessible eye cell phones and their increasing comfort with all kinds care to individuals in underserved communities. This of electronic communications, Dr. Woodward believes technology will also improve care by allowing providers that, with proper training, medito detect eye conditions earlier cal staff and patients could capin their course. Dr. Woodward “Validating telemedicine for ture usable images of corneal has been awarded a National and external eye diseases. “The Institutes of Health K23 grant eye diseases is critical so we technology is here today — and for her research project entitled, Telemedicine for Anterior Eye maintain the highest standards it will only get better,” she says. The focus of the work is Diseases. According to the National of patient care while moving in to not only validate the ability of telehealth to promote highEye Institute (NEI), the majority quality care, but to also develop a of visits to eye care providers nathe ‘digital’ health care era.” system to implement care that can tionally are the result of diseases — Maria A. Woodward, M.D. be directed by ophthalmologists. that affect the anterior, or front “Validating telemedicine for part of the eye, such as cataract eye diseases is critical so we maintain the highest stanor corneal diseases. While the NEI has emphasized dards of patient care while moving in the ‘digital’ health the need to develop telemedicine technologies to care era,” says Dr. Woodward. diagnose and monitor patients with eye diseases from Once developed, high quality teleheath systems afar, less attention has been focused on anterior will help prevent a shortage of eye care services as our segment conditions. population grows and ages. Telemedicine, telehealth, and e-health generally refer to the sharing of medical information between 6

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Improving Patient Care is no small measure Kellogg works to ensure quality care at the local, state, and national levels

Dr. Jennifer Weizer is leading Kellogg’s initiative to report on quality of care.

care for our patients.” In the public debate on health care, pundits and patients At the state level, Dr. Weizer is leading the Collabare talking more and more about quality of care. But orative Glaucoma Quality Initiative (CGQI), a study what does “quality” mean and how can it be measured? to report and improve how physicians follow glauThe University of Michigan Kellogg Eye Center is concoma patient visit guidelines provided by the American tinuously collecting data to help patients better underAcademy of Ophthalmology (AAO). If physicians can stand the indicators of quality eye care. improve how well they follow these guidelines, they Under the leadership of Jennifer S. Weizer, M.D., could help delay the progression of glaucoma and thus associate professor and glaucoma specialist, Kellogg improve outcomes, quality of life, has measured its performance for nearly ten years. In partnership with “We measure our outcomes and reduce health care costs. For the CGQI, Kellogg is the University of Michigan Health partnering with the Grand Traverse System’s Quality and Safety group, quarterly and then share Ophthalmology Clinic and the Kellogg recently published its first set of quality outcome measures, the results with our faculty. Henry Ford Department of Ophthalmology to look at new glauincluding rates of unplanned reopThis information helps us to coma patient visits. Each group erations, postoperative infections, reviews and records — on a checkand success of specific procedures. improve how we teach our box form void of patient informaThese data measure the quality tion — whether these visits included of care for all patients treated for residents and how we care the major exam aspects recomspecific eye diseases (e.g., cataracts, mended by AAO guidelines. Results retinal detachment, and strabismus) for our patients.” will then be compiled, averaged, and for those who have had eye and reported back to the groups. surgery (such as corneal transplants; — Jennifer S. Weizer, M.D. Nationally, Dr. Weizer is a and glaucoma, retinal, refractive member of the AAO’s Registry Measure Development and oculoplastic surgery) at Kellogg. Workgroup, which is using electronic health records Only a few ophthalmology departments in the to develop the nation’s first comprehensive eye disease country have such an extensive program, making clinical database — the Intelligent Research in Sight Kellogg a leader, at both the state and national (IRIS) Registry. IRIS will report data to help validate levels, in measuring and improving patient care. the quality of care provided by ophthalmologists and “Our program is broad and deep in that it highlight areas for improvement — all with the goal of covers all of our subspecialties, which is unusual for improving the delivery of eye care. ophthalmology departments,” says Dr. Weizer. “We measure our outcomes quarterly and then share the Kellogg outcomes are online at www.uofmhealth.org/ results with our faculty. This information helps us quality-safety to improve how we teach our residents and how we Innovation in vision

Dr. Stephanie Chu in Kellogg's Low Vision Clinic.

Dr. Alan Robin meets with young physicians from the Robert Wood Johnson Foundation Clinical Scholars Program at Michigan.

Global Ophthalmology Kellogg Center for International Ophthalmology fosters the exchange of knowledge and best practices globally

Kellogg Faculty Develop Training Programs for International Physicians Stephanie Chu, M.D., National Taiwan University Hospital, was the first international physician to complete a new course on specialty contact lens fitting offered at the Kellogg Eye Center. The course was developed by clinical instructor Sherry H. Day, O.D., and thirteen other faculty members. “I was fortunate to spend two months at the Kellogg Eye Center. My overall experience was outstanding,” says Dr. Chu. “During my stay, I studied comprehensive contact lens fitting and low vision assessment. This helped me to understand the long-term results of a variety of specialty lenses, and will assist me in handling difficult ocular surface diseases or postsurgical corneal conditions.” While at Kellogg, Dr. Chu was introduced to new low vision aids and low vision services offered in the United States. “I was impressed with the efficiency and collaboration between social workers and medical professionals in this area who combined their resources to help visually-impaired patients,” says Dr. Chu.

university of michigan kellogg eye center

Dr. Chu also had the opportunity to observe Kellogg’s residency training program. “The program is flexible and accommodating to the needs of residents—providing an abundance of resources such as lectures, clinics, and surgical procedures,” says Dr. Chu. Based on the model she observed at Kellogg, Dr. Chu will make recommendations on modifying the resident training program at the National Taiwan University Hospital. Kellogg Resident Compares Ophthalmic Quality Measures As the United States evaluates how it delivers health care, there are lessons to be learned from the United Kingdom’s long-standing National Health System (NHS) and, specifically, from the Royal College of Ophthalmologists (RCOphth). Monica Michelotti, M.D., a second-year resident, recently completed a research rotation at the Royal Bolton Hospital (RBH) in Bolton and Moorfields Eye Hospital (MEH) in London. She conducted a compara-

Hong-Gam Le (second from left) with Aravind Eye Hospital managers R. Ushalini, MBA; A. Shobana, B.Sc., PGDHM; and R. Anjana Deep, MBA.

tive analysis of health care delivery systems in the U.K. and the U.S. through the prism of ophthalmology. Dr. Michelotti collaborated with Simon P. Kelly, MB BCh, one of the U.K.’s leading specialists on quality and safety in ophthalmology. She also studied patient safety and quality assurance with Declan W. Flanagan, MB BCh, medical director at MEH. Dr. Michelotti reviewed the World Health Organization’s universal checklist for safer surgery, and compared quality measures in different countries. She will present her work at the upcoming World Association of Eye Hospitals meeting at Aravind. “This rotation allowed me to focus on research that could help shape the future of health care,” says Dr. Michelotti. Her work comparing existing standards and measures of quality of care among ophthalmology units around the world will help harmonize these standards and accelerate our ability to determine what works best for patients. U-M Team Works with Aravind to Assess Cataract Surgery Under the guidance of Kellogg glaucoma specialist Joshua D. Stein, M.D., M.S., and colleagues from Aravind and Michigan, second-year medical student Hong-Gam Le compared the Aravind Eye Hospitals’ high-volume, high-quality, low-cost system of cataract surgery with ours.

Dr. Joshua Stein and Hong-Gam Le review data on cataract surgery.

Ms. Le completed an eight-week research rotation at the Aravind Eye Hospitals in both Madurai and Pondicherry, India, jointly sponsored by the U-M Medical School Student Biomedical Research Program and the Kellogg Center for International Ophthalmology. By taking a detailed clinical, work-flow, and resource-based perspective, the study team suggested how we might make our system of cataract surgery more efficient. Center Collaborates with First Visiting Scholar Alan L. Robin, M.D., Professor of Public Health and Ophthalmology of the Bloomberg School of Public Health and the Wilmer Eye Institute, Johns Hopkins University, is collaborating with the Kellogg Center for International Ophthalmology to address vision problems in the United States and abroad. “We are working with the Aravind Eye Care Hospital in Tamil Nadu, India, and the Tilganga Eye Hospital in Kathmandu, Nepal, to develop systems, through telemedicine, to screen with high sensitivity and specificity individuals at early stages of glaucoma, so that we can prevent needless blindness,” says Dr. Robin, the first Visiting Scholar to the Center for International Ophthalmology. “Strategies that we develop together with Michigan and our global partners might well be used in both developing nations and in underserved areas of our countries such as big cities or rural sections of America.”

Innovation in vision

To fuel new ideas in vision research: The Paul R. Lichter, M.D.,

Research Discovery Fund

Thanks to dedicated contributors, endowment exceeds initial goal and keeps growing When an ophthalmologist imagines a new approach to solving a patient’s eye problem or a scientist begins to follow a discovery in an unintended direction, that’s where progress begins — but only if the resources are in place to test whether the hunch has potential. “The process for developing a research project that can advance treatments for eye disease starts with gathering data and studying the initial idea,” says Paul R. Lichter, M.D. “So it is imperative that we support innovation at its earliest stages. Then the project can compete for traditional funding. But it has to get that far. We don’t want to leave any good ideas behind.”

university of michigan kellogg eye center

Endowed funds that are part of the Paul R. Lichter, M.D., Research Discovery Fund: Thomas W. Breakey and Rutger W. Breakey Ophthalmic Research Fund Robert W. and Lynn H. Browne Glaucoma Research Fund Paul R. and Carolyn R. Lichter Glaucoma Research Fund Mary L. and Brian P. Campbell Research Discovery Fund Colette J. and Albert F. Kessel Research Discovery Fund Joel S. Mindel, M.D., Ph.D., and Susan Weis Mindel Ophthalmic Research Fund Oliver Family Ophthalmic Research Fund Edward Berger Endowed Research Fund

That’s the purpose of the Paul R. Lichter, M.D., Research Discovery Fund, which is providing grants to faculty whose early-stage work has the potential to advance vision science. The first round of grants will be distributed in early 2014. The Fund, which has topped more than $4 million in gifts and pledges, was created in honor of Dr. Lichter when he stepped down as chair of the Department of Ophthalmology and Visual Sciences in 2012, a post he held for 34 years. He is also the Founding Director of the W.K. Kellogg Eye Center, which was established under his leadership in 1985. During his tenure, Dr. Lichter built a robust, world-class vision research program.

Detroiter Makes Lasting Gift to Vision Research Edward Berger, a native Detroiter who worked for the city in tax collections, was the last of four siblings, three of whom never married. None had children. “He survived all of his siblings, and his assets grew as a result,” explains Jon B. Gandelot, a Grosse Pointe Farms attorney who assisted Mr. Berger with his estate plans. “He suffered from age-related macular degeneration, and supporting the Kellogg Eye Center struck a chord with him.” When Mr. Berger passed away in 2012, Mr. Gandelot had U-M establish the Edward Berger Endowed Research Fund, part of the Paul R. Lichter, M.D., Research Discovery Fund. A portion of the estate was also designated for Alzheimer’s disease research at U-M. “Ed wanted to leave a legacy,” Mr. Gandelot says. He wanted to make sure that the world was better off as a result of him being here.”

“It means a great deal to me that this Fund will ensure the future of such important work, and I am grateful for the wide support it has received,” says Dr. Lichter. Contributors to the Fund include patients, alumni, colleagues, friends, and family, as well as Dr. Lichter and his wife, Carolyn. The Lichter Discovery Fund also serves as an umbrella fund for named endowments that share its goals (see list above). The Kellogg Eye Center has committed to making the Lichter Discovery Fund an ongoing fundraising priority due to our commitment to supporting high-reward, high-risk research.

Innovation in vision

The 10 recipients of Audacious Goals in Vision Research awards. Back row: Russell Van Gelder, M.D., Ph.D., University of Washington; Jeffrey Stern, M.D., Ph.D., Regenerative Research Foundation, Rensselaer, NY; Robert Duvoisin, Ph.D., Oregon Health & Science University; Julia Richards, Ph.D., University of Michigan; Steven Pittler, Ph.D., University of Alabama at Birmingham; Rajesh Rao, M.D., Washington University in St. Louis, currently, University of Michigan. Front row: Paul Sieving, M.D., Ph.D., Director, National Eye Institute; Yingbin Fu, Ph.D., University of Utah; Janey Wiggs, M.D., Ph.D., Massachusetts Eye and Ear Infirmary; Tonia Rex, Ph.D., Vanderbilt University; Dennis Clegg, Ph.D., University of California, Santa Barbara.

Kellogg Scientists Offer “Audacious” Ideas to advance national vision research By winning awards from the National Eye Institute (NEI), Kellogg scientists Rajesh C. Rao, M.D., and Julia E. Richards, Ph.D., are helping to set the national vision research agenda. In 2013, the NEI challenged scientists from around the world to develop ideas that would help steer vision research for the future. Proposals from Drs. Rao and Richards for the Audacious Goals in Vision Research competition were two of only 10 selected from several hundred submissions. The winning proposal from Dr. Rao — who won the award during his vitreoretinal surgery fellowship at Washington University in St. Louis before joining the Kellogg faculty in 2013 — is Reprogramming the Retina. His research involves reprogramming easy-to-isolate skin or blood cells and transplanting them into the retina as well as reprogramming surviving retinal cells into specific cell types to replace those that are damaged. “Kellogg — and the University as a whole — are great places to pursue this work because of their interest in regenerative medicine, their collaborative environment, and their expertise with epigenetics and stem cells,” he says. 12

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Dr. Richards, the Harold F. Falls Collegiate Professor of Ophthalmology and Visual Sciences and professor of epidemiology in the U-M School of Public Health, won for her proposal, Fountains of Youth for the Eye. Serious late-onset problems like macular degeneration and glaucoma result from a complex combination of many different genetic and environmental risk factors. Dr. Richards proposes that instead of developing multiple treatments targeting many complex causes, we could delay onset of these diseases by intervening in the one thing the diseases have in common — the aging process. “The interconnection of clinical and basic sciences at Kellogg offers an excellent environment for the evolution of interdisciplinary ideas,” she says. The NEI drew from the 10 winning proposals to develop one single goal — regenerating neurons and neural connections in the eye and visual system — along with two high-priority research areas — molecular therapy for eye disease and the intersection of aging and biological mechanisms of eye disease.

Awards for Resident Research Grant allows residents to pursue research that sparks their interest

Ryan Fante, M.D.

Now in its second year, the Michigan Ophthalmology Trainee Career Development Award (MOTCDA) has provided six residents with the opportunity to pursue research projects that spark their interest. Read about two of our winners for the 2013–14 academic year. Ryan J. Fante, M.D., third-year resident, received grant funding for his research on macular edema (ME), or swelling in the back of the eye, that can be the result of diabetes or radiation treatment. Dr. Fante is working to better understand the protein changes that accompany different types of ME and to identify potential new therapeutic targets. He also plans to characterize the normal and pathologic composition of the vitreous in various disease states. The vitreous is thought to contain signaling molecules that lead to ME or are markers for response to certain treatments for this condition. “The MOTCDA is an award that provides support for residents who are aspiring clinician-scientists,” says Dr. Fante. “In this case, it provided the funding to initiate a basic science project to develop some of my ideas about diabetic retinopathy. The unique collaboration between our ophthalmology department and the medical school also allowed us to run assays that would not have otherwise been possible.”

Ira Schachar, M.D., M.Sc.

Ira H. Schachar, M.D., M.Sc., third-year resident, received grant funding for his research on the use of the femtosecond laser for glaucoma treatment. Open-angle glaucoma is characterized by high intraocular pressure (IOP). When topical medications and laser trabeculoplasty have been ineffective in lowering IOP, the next step is typically surgery directed at the anterior chamber of the eye. Clinician-scientists work to find alternatives to minimize surgical complications and maintain lower IOP in the long term. Dr. Schachar's research assessed if the femtosecond laser is an effective alternative for glaucoma surgery. “The opportunity to collaborate with the U-M College of Engineering through MOTCDA has taken this project from an idea to a reality,” says Dr. Schachar. “With preliminary work from the MOTCDA funding, we have applied for a larger developmental grant aimed at understanding how best to use this technique.” Read about the MOTCDA award of second-year resident Monica Michelotti, M.D., on page 8.

Innovation in vision

Support for interdepartmental collaboration and innovative training models drew Dr. Miller to the University of Michigan.

What happens when aging retinal cells stop

“Taking Out the Trash?” Live-cell imaging techniques could reveal where disruptions occur One of Kellogg’s newest postdoctoral fellows is using live-cell imaging techniques to understand what happens when the retinal pigment epithelium (RPE) falls down on its job of removing waste from the retina. Photoreceptors shed 10 percent of their outer segments every day, which are then engulfed and digested by the RPE. The breakdown products are either recycled back to the photoreceptors or disposed of via another layer of the eye, the choroid. A single RPE cell carries out this waste disposal function day-in and day-out; however, as the cell ages, its ability to handle the “trash” diminishes, resulting in the accumulation of fatty waste byproducts (lipofuscin and drusen). The RPE’s declining function likely plays a major role in dry age-related macular degeneration (AMD), a leading cause of vision loss. Postdoctoral fellow Jason M. Miller, M.D., Ph.D., is investigating which steps in this disposal process are disrupted as the RPE ages. Dr. Miller’s research includes 14

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the use of automated live-cell imaging techniques first developed in his graduate lab at the University of California, San Francisco. A long-term goal of his research at Kellogg is to identify drugs that improve the recycling capacity of the RPE, which then could be developed as therapeutic candidates for dry AMD. Dr. Miller, who conducts research in the labs of Kellogg’s Debra A. Thompson, Ph.D., and David N. Zacks, M.D., Ph.D., will collaborate with new U-M faculty member Sami J. Barmada, M.D., Ph.D., assistant professor of neurology, who shares expertise in advanced microscopy techniques. Among the reasons he chose to pursue research at Michigan, says Dr. Miller, is the University’s degree of interdepartmental collaboration and support of young faculty members. “However,” he adds, “it was the ophthalmology department’s wholehearted embrace of innovative training models, supporting academic interests ranging from education to policy to international development to engineering to basic research, that made Kellogg singularly unique for a young physician-scientist such as myself.”

S t u d y i n g abnormal growth of retinal blood vessels in eye complications of diabetes Donald G. Puro, M.D., Ph.D., professor of ophthalmology and visual sciences and molecular and integrative physiology, recently had his National Institutes of Health research grant (R01) renewed for his project, Retinovascular Pathophysiology: Focus on Proliferative Retinopathy. Through his continued research, Dr. Puro hopes to better understand the pathophysiological changes that accompany the abnormal growth of retinal blood vessels, which is a serious complication of diabetes and premature birth. He hopes this knowledge will lead to new therapies for these major sightthreatening disorders. “This research is relevant because it may lead to new pharmacological approaches for treating this dreaded complication of diabetes,” says Dr. Puro. “Despite the benefits of currently used therapies, the complication of proliferative retinopathy continues to be a leading cause of blindness. Findings of this research could also extend to advances in the treatment of retinopathy of prematurity and other serious eye disorders in which aberrantly growing blood vessels cause sightthreatening damage to the retina.” Dr. Donald Puro with postdoctoral fellow Maho Shibata, M.D., Ph.D.

Researching Retinal Detachments i n o u r p e d i at r i c pat i e n t s Cagri G. Besirli, M.D., Ph.D., assistant professor and pediatric retina specialist, received a National Institutes of Health K08 grant for his project, Neuroprotection in Pediatric Retinal Detachment. Pediatric retinal detachment is a significant cause of childhood blindness in developed countries. One of the common characteristics of inherited or acquired pediatric retinal detachments is leakage of fluids — including blood and fat-like substances — under the retina that causes

photoreceptors to separate from the retinal pigment epithelium (RPE) and eventually die. However, once the retina is re-attached, many children regain limited vision, which indicates that some photoreceptors are able to survive separation from the RPE. Dr. Besirli plans to use both animal model and human samples to identify the protective mechanisms on a cellular level that keep photoreceptors alive. “The goal of the five-year study,” says Dr. Besirli, “is to develop novel therapies to prevent vision loss in our youngest patients with retinal disorders.” Innovation in vision

Immunofluorescent stain of the anterior segment (front of the eye) in a mouse model, from the lab of Philip Gage, Ph.D.

Finding the Pathways to Regenerative Medicine What we can learn by studying how the eye develops and how it responds to injury In the years ahead, regenerative medicine could spawn a new class of therapeutics to treat eye disease and restore vision. New cell-based therapies might promote healing by inserting new cells into diseased tissue or reactivating stem cells that proliferated during the eye’s development. Scientists at the Kellogg Eye Center are pursuing two broad avenues of research to realize the promise of regenerative medicine. Some are studying the fundamentals of eye development to understand more completely how the structures of the eye are formed and what happens when things go awry. Others are investigating mechanisms of tissue and cell regeneration in the mature eye. In their experimental models, our scientists have observed populations of stem cells that they believe could be harnessed for therapeutic uses. Zebrafish, for example, have the unique and fascinating capacity to generate new cells in response to injuries to the retina and to muscles of the eye. 16

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Here are a few examples of how Kellogg scientists are laying the groundwork to advance the field of regenerative medicine:

How the drainage channel develops and how errors can lead to glaucoma in children Understanding how the eye develops is the starting point for regenerative medicine. Brenda L. Bohnsack, M.D., Ph.D., whose clinical specialty is pediatric glaucoma, studies how the front (or anterior) part of the eye develops, using the zebrafish as her model. Missteps in development in this area can result in eye diseases like congenital glaucoma. One of the unique aspects of eye development in both zebrafish and humans is the role of the neural crest, a population of stem cells that exist in the embryo for a short time and then differentiate — or change — into cells that form structures all through the body, including the eye. These neural crest cells give rise to a structure central to Dr. Bohnsack’s research and clinical practice. “I am interested in the angle at the junction of the iris and cornea that allows fluid to drain from the eye,”

Brenda Bohnsack, M.D., Ph.D., (center) with Bahaar Chawla and Amy Stevenson.

Philip Gage, Ph.D., (far right) with Chen Kuang and Lisheng Chen, Ph.D.

she says. “When the drainage channel is not properly formed in the embryo, the result can be elevated eye pressure, damage to the optic nerve, and congenital glaucoma.” According to Dr. Bohnsack, “Once we understand at the genetic level how the healthy eye develops, we can study what goes wrong when disease occurs and intervene either by rebuilding or repairing these essential channels.” Dr. Bohnsack has been awarded a National Institutes of Health K08 grant to study regulation of the neural crest and its implications in congenital eye disease.

mature eye. When it is withdrawn in experimental models, the optic nerve deteriorates — and glaucoma is induced. The discovery is significant because it now appears that Dr. Gage has an “inducible” glaucoma model that allows scientists to observe how the disease develops over a narrow timespan. “The rapid onset of optic nerve change in our model, as compared to others, makes this a useful resource for our lab and for the larger glaucoma community,” says Dr. Gage. “The model could also be used to test the effectiveness of new therapies for preventing glaucoma and vision loss often associated with the disease.”

Studying a gene that influences the development of structures in the front of the eye

Understanding eye muscle regeneration and the path to new therapies

Building the fine structures of the front of the eye requires coordination and communication among embryonic cell tissues, a process that is “quite an engineering feat,” says developmental geneticist Philip J. Gage, Ph.D. The way his lab “listens in” on the process, says Dr. Gage, is to study PITX2, a gene whose function is to control the activity of other genes. Dr. Gage has identified the gene as a key regulator at multiple stages of eye development. A mutation in PITX2 is a cause of Axenfeld-Rieger syndrome, a condition marked by abnormalities in the front of the eye. About half of those with this syndrome will develop glaucoma, usually in childhood or adolescence. Dr. Gage has also shown that PITX2 is essential in developing both the cornea, the clear front of the eye, and the angle structure. And most recently he reported that the gene is required to maintain the health of the

Alon Kahana, M.D., Ph.D., scientist and oculoplastics surgeon, is interested in the orbit of the eye, the bony structure that protects the eye, and the muscles that control eye movement. When eye muscles do not develop properly, one result can be congenital strabismus, a disorder in which the child’s eyes are not aligned, resulting in compromised vision. New therapies for strabismus and other eye muscle disorders could emerge from Dr. Kahana’s unique zebrafish model. In a recent study, he found that zebrafish can regenerate new eye muscle tissue even after 50 to 80 percent of the muscle has been removed. Dr. Kahana has been awarded a National Institutes of Health R01 grant to identify the biological mechanisms that underlie repair and regeneration of eye muscle tissue in response to injury. “Understanding more about this remarkable capacity for regenerating Innovation in vision

Alon Kahana, M.D., Ph.D., left, with researchers Bahaar Chawla and Philip Kish, Ph.D.

Peter Hitchcock, Ph.D., second from left, and his research team, Travis D’Cruz, Ph.D., Esther Gramage, Ph.D., Dilip Pawar, Ph.D., Caroline Walsh, Laura Kakuk-Atkins, M.S., and Scott Taylor, Ph.D.

healthy tissue will certainly contribute to the broader “We are interested in the early events that give rise fields of stem-cell biology and regenerative medicine,” to the mature retina: the proliferation of embryonic says Dr. Kahana, the Helmut F. Stern Career Developcells and their differentiation into functional cell types,” says Dr. Hitchcock, professor of ophthalmology and ment Professor. visual sciences and cell and developmental biology. Studying the regenerative process is leading the Dr. Hitchcock’s lab also investigates mechanisms in Kahana lab to investigate changes in the brain that the mature retina that govern stem-cell-based regeneraoccur when eye muscles are injured. “Because the brain tion of photoreceptors after injury. “In a broad sense,” controls neural activity related to vision, we are beginsays Dr. Hitchcock, “we hope to anning to ask how the brain remodels and regenerates in response to injury “Regenerative processes swer the question: ‘What does a stem cell require to make a photoreceptor?’ to the eye muscle,” says Dr. Kahana. are tightly controlled — And, we’re looking at this in a model And, he adds, “the timing is where regeneration occurs in a very fortuitous.” The National Eye Instiexquisitely controlled — robust way when photoreceptors are tute has issued its key “audacious” destroyed.” research goals. Number one on that and it’s this exquisite This vigorous action is not unlike list involves remodeling neural connections in the visual system. the proliferation of cells in cancer. control that we have to “One of the themes that is clear to everybody working in these fields is Investigating development of understand.” that developmental, regenerative, and the retina and regeneration cancer biology are mechanistically after injury to the adult retina — Peter F. Hitchcock, Ph.D. linked,” says Dr. Hitchcock. “SignifiResearch in the lab of neurobiologist cantly, however, cell proliferation in cancer is unreguPeter F. Hitchcock, Ph.D., spans the biological lated, which is a hallmark of that disease. By contrast, spectrum. Using the zebrafish model, his lab studies regenerative processes are tightly controlled — exquithe molecular and cellular processes that govern both sitely controlled — and it’s this exquisite control that we the development and regeneration of retina cells. have to understand.” Among these cells are photoreceptors, light-sensing The zebrafish’s capacity to repair tissue could be an cells essential for vision that are part of the central apt model for stem-cell-based therapies. “We hope some nervous system. When these cells do not form properly part of our work informs that approach to treating or become damaged later in the adult eye, diseases brain and retinal injuries,” says Dr. Hitchcock. such as age-related macular degeneration and retinitis pigmentosa can occur. 18

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Is It Possible to Reprogram Cells to Repair Eye Tissue? Epigenetics provides insight into how genes function and the mechanisms that control them — and could pave the way for regenerative therapies

Through the study of epigenetics, Dr. Rajesh Rao sees potential for cell-based therapies for eye disease.

cells contain the same DNA, their genes are expressed One of the most fascinating therapies being discussed differently, which creates distinct cell identities,” says Dr. today is the possibility of reprogramming cells to repair Rao. “Using small molecules that can manipulate chemidamaged tissue. Retina specialist Rajesh C. Rao, M.D., cal modifications in chromatin in the laboratory, a skin points to several studies in which skin-derived cells have cell could be reprogrammed to become a functioning been coaxed to become brain and heart cells in a petri retinal cell.” dish. While it will be some years before the technology Dr. Rao will study specific types of epigenetic can be applied to treating disease, Dr. Rao is joining regulators associated with gene expression and represU-M and Kellogg scientists in applying knowledge from sion, but whose function is not yet the field of epigenetics to advance “Using small molecules understood in the retina. “A better regenerative therapies in the eye. understanding of chromatin-mod Epigenetics, meaning “after or bethat can manipulate ifying enzymes may one day allow yond genetics” refers to modifications reprogramming of diseased or scar-asin genes that lead to variations in exchemical modifications sociated fibroblast cells (as in macular pression of those genes. The modificadegeneration) into functional, light tions, some of which are passed from in chromatin in the labosensing cells,” says Dr. Rao. one generation to the next, can be Dr. Rao is collaborating with induced by environmental factors such ratory, a skin cell could researchers involved in epigenetics and as diet and smoking that can activate drug discovery across the University. or silence genes. be reprogrammed to “We want to use stem-cell biology “Gene expression is regulated by and epigenetics as languages to better chemical modifications to DNA and become a retinal cell.” understand disease mechanisms in its associated proteins,” says Dr. Rao. — Rajesh C. Rao, M.D. blinding retinal diseases, with the goal “DNA is wrapped around proteins of developing novel pharmacologic to form a structure called chromatin. gene and cell-based therapies for our patients.” Chromatin can be opened and closed. When chromatin around specific genes is open or relaxed, gene expresDr. Rao has joined the Department under the National sion can proceed. When chromatin is closed or tightly Eye Institute (NEI) K12 Michigan Vision Clinicianwound, the gene cannot be expressed and is silenced.” Scientist Development Program, an award that provides Under a National Eye Institute K12 grant, Dr. Rao training and mentorship to young ophthalmologists will investigate the mechanisms that turn our genes “on” planning to develop careers as clinician-scientists. The and “off,” and, ultimately, either lead to a diseased state, Department is one of only six in the nation to be able or to health in the eye and retina. “Epigenetics explains to offer this award. why a skin cell is different from an eye cell. While both Innovation in vision

Research by Kellogg Team Leads to

Largest Multi-Center Clinical Trial for Graves’ Eye Disease Findings provide inroads into novel therapies with potential to safely minimize severity and duration of disease Individuals suffering from Graves’ eye disease (GED), also known as thyroid eye disease (TED), have had very few treatment options available to them — without the risk of significant side effects and safety concerns. Now a clinical trial evaluating the efficacy and safety of a new therapy for TED has begun, the result of over 25 years of research led by the Kellogg team of Terry J. Smith, M.D., an endocrinologist and Frederick G.L. Huetwell Professor of Ophthalmology and Visual Sciences, and Raymond S. Douglas, M.D., Ph.D., a specialist in Graves’ eye disease and renowned oculoplastics surgeon.

Dr. Terry Smith with patient Ruth Horyn and clinical research project manager Karen King. 20

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TED is a visually debilitating and potentially disfiguring condition associated with Graves’ disease, an autoimmune disorder that causes the overproduction of thyroid hormones, or hyperthyroidism. Approximately one million Americans have been diagnosed with TED. Symptoms include swelling of the eyelids and tissue around the eye, a constant stare, bulging eyes, eyelid retraction, and loss of vision. In severe cases, the cornea may ulcerate, or the optic nerve may be damaged. Either complication may result in permanent loss of vision if not treated appropriately. Approximately 25 to 50 percent of individuals with Graves’ disease will develop TED. “The eyes are particularly susceptible to Graves’ disease because the autoimmune attack often targets the eye muscles and connective tissue surrounding the eye,” says Dr. Douglas. “This occurs as a consequence

Fluorescent imaging of Graves’ disease fibroblasts treated with insulin growth factor-1 (IGF-1) with or without the steroid, dexamethasone (Dex).

Sonal Trivedi, clinical research coordinator; Dr. Raymond Douglas; Karen King, clinical research project manager; Dr. Terry Smith.

“The goal of this trial is to determine whether of these tissues containing proteins that are shared with administering RV 001 early in the active phase of TED the thyroid gland.” will safely minimize the severity and duration of the dis The team’s findings point to the apparent involveease, have a favorable effect on long-term outcome, and ment of the insulin-like growth factor 1 (IGF-1) receplessen the need for corrective surgeries,” says Dr. Smith. tor in Graves’ disease and other autoimmune diseases. “This investigative drug has worked in the test tube and “Specifically, we have found that there is an unusually now it could work in the human being.” Moreover, the high presence of IGF-1 receptors on cells surrounding team has emerging evidence that RV 001 might be at the eye in TED,” says Dr. Smith, widely recognized least as useful in treating rheumafor his groundbreaking research “This investigative drug toid arthritis and type 1 diabetes. on treatments for TED and related Sponsored by River Vision autoimmune disorders. has worked in the test Development Corporation, the Building on this discovery, an clinical trial will enroll approxioutgrowth of basic science research tube and now it could work mately 84 individuals who have had conducted at the University of Calisymptoms of TED for less than six fornia, Los Angeles, and then at the in the human being.” months and who have not received Kellogg Eye Center, Drs. Smith and any treatment, with the exception Douglas have initiated the largest — Terry J. Smith, M.D. of lubricating eye drops. Drs. Smith multi-center clinical trial for TED in and Douglas are the principal investigators of the study the United States, called the Graves’ Eye Disease Study. encompassing 22 study centers throughout the country The study will examine the potential therapeutic that will participate in the trial, which is expected to benefit of a monoclonal antibody known as RV 001 run through 2014. that blocks the IGF-1 receptor, originally developed as a cancer drug. Although the drug failed to exhibit efficacy To learn more about the trial visit: in patients with cancer, the team believes it may be a https://umclinicalstudies.org/HUM00073174 useful therapy in interrupting the TED disease process, given its specific targeting of the IGF-1 receptor. Innovation in vision

Inv es t i g at i n g s u b co n s c i o us

Dr. Kwoon Wong has been awarded new grants to study subconscious response to light.

Neuroscientist Kwoon Y. Wong, Ph.D., has been awarded a National Institutes of Health R01 grant for his project, Physiology of Intrinsically Photosensitive Retinal Ganglion Cells. Intrinsically photosensitive retinal ganglion cells (ipRGCs) are recently discovered retinal nerve cells that drive subconscious physiological responses to light — such as regulating hormone secretion, enhancing alertness, and synchronizing sleep timing to the light/ dark cycle. “Recent discoveries have shown that the eye supports not only conscious vision but also various subconscious physiological responses to light that are crucial to our well-being,” says Dr. Wong. Under the five-year study, Dr. Wong will investigate two aspects of ipRGCs: the molecular mechanisms that enable such cells to respond to light, and the communication between these cells and other cells in the retina. Dr. Wong has also received a Department of Defense Army Research Office grant for another 22

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project, Modeling Subconscious Vision, in which he serves as a co-principal investigator. In this project, Dr. Wong has teamed up with Daniel B. Forger, Ph.D., University of Michigan Department of Mathematics, to construct mathematical models that explain the inner workings of ipRGCs and related retinal cells. These models will enable Drs. Wong and Forger to predict how these cells would respond to any kind of light stimulus. The long-term goal of these projects is to help develop light therapies for depression and sleep disorders, novel lighting technologies that enhance productivity at work and school, and better diagnostic tests for eye disorders. In addition, these studies could lead to new strategies for restoring vision in the blind. “Interestingly, ipRGCs remain light-responsive in many people who are blind,” says Dr. Wong. “A better understanding of the physiology of ipRGCs should help us devise new ways to enhance their photosensitivity, which could help improve the visual capability of people who are blind.”

Kellogg residents gather in the state-of-the-art Kittendorf Resident Education Center. Back: Neil Farbman, J.D., M.D., Lee Kiang, M.D., Ph.D., Abigail Fahim, M.D., Ph.D. Front: Maxwell Stem, M.D., Kevin Tozer, M.D., Denise Kim, M.D., Andrew Stacey, M.S., M.D.

Attorney’s Estate Gift Creates a Legacy

Born in Detroit in 1937, Mr. Kittendorf moved with his family to Sebewaing, Michigan, where he graduated from high school in 1955. He earned a bachelor’s degree at Michigan State University and served for two years in the U.S. Army. When he returned, he enrolled of Learning and Hope in the Detroit College of Law, joining the State Bar of Roger W. Kittendorf, a Genesee County attorney and Michigan’s Master Lawyers Section in June 1967. businessman who passed away in late 2012, was a He spent time as an assistant prosecutor for thoughtful investor in organizations he believed would Genesee County and as a lawyer for Vienna Township make a difference in people’s lives. His generous supin Clio before opening a private office. He built a robust port of the Kellogg Eye Center, practice and invested in real estate “As a student and an adult, which included gifts to research throughout his career. In his free and to a new resident education time, he enjoyed golfing and internaI have always admired the center, culminated with the news tional travel. He continued working that Kellogg would be the primary until he passed away at the age of 75. University of Michigan’s beneficiary of his estate. Mr. Kittendorf said he felt privi As a long-time Kellogg patient leged to be able to share his success quest for excellence.” and supporter, Mr. Kittendorf with others, and while he requested became a partner in the work anonymity for the gifts he made — Mr. Roger Kittendorf that is done here. He engaged his during his lifetime, the Kellogg Eye physician, glaucoma specialist Sayoko E. Moroi, M.D, Center is now able to thank him publicly, naming the Ph.D., in conversations about research, which led to Roger W. Kittendorf Resident Education Center. his support of specific projects. As a former teacher, he “Our patients have an incredible understanding of was intrigued that Kellogg has one of the top programs how precious eyesight can be — and how fragile,” says in the country for training physicians who want to Paul P. Lee, M.D., J.D., F. Bruce Fralick Professor and specialize in ophthalmology. Mr. Kittendorf learned Chair of the Department of Ophthalmology and Visual that Kellogg hoped to build a state-of-the-art education Sciences. “When they are able to help us help others, center, and he made construction of the facility possible. our impact is multiplied many times over. We are very It opened on the sixth floor of the original Kellogg Eye grateful for Mr. Kittendorf’s commitment to vision.” Center tower in 2011. “As a student and an adult, I have always admired To support vision research, you can make the University the University of Michigan’s quest for excellence,” Mr. of Michigan a beneficiary of a 401K or other savings or Kittendorf said at the time of his gift to the education insurance plan. You can also designate funds through center. “Since I have reached a point in life where I have a will. For information, please contact Becky Spaly at the resources to assist, I couldn’t resist the opportunity.” 734.763.0874 or at bsp@umich.edu. Innovation in vision

The Pipernos with the Symposium Organizing Committee. Back row: Paul Lichter, M.D., Bruno Piperno, Celeste Piperno, John Heckenlively, M.D., William Hauswirth, Ph.D., Alessandro Iannaccone, M.D., David Zacks, M.D., Ph.D.; Front row: Debra Thompson, Ph.D., Robin Ali, Ph.D.

Advancing a Shared Mission A couple partners with Kellogg to host international conference on retinal diseases When more than two dozen physicians and scientists from around the world gathered in Tuscany this fall to discuss innovative treatments for blinding retinal dystrophies, hosts Celeste and Bruno Piperno realized a long-held dream. They often help individuals with eye conditions navigate the health care system in Rome, where they own a business consulting firm and Mr. Piperno seeks care for an inherited retinal condition. Yet they have always wanted to do more. By partnering with the Kellogg Eye Center and providing researchers with the ideal location for an international scientific meeting — Tenuta di Monaciano, a resort and vineyard that has been in their family since the early 20th century — they made a unique contribution to the field. “This is a crucial time in retinal degeneration research, and the need for us to work together as an international community has never been greater,” says meeting coordinator Debra A. Thompson, Ph.D., 24

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Professor of Ophthalmology and Visual Sciences and Professor of Biological Chemistry at the University of Michigan. “We are making great strides in gene and stem-cell therapies, but pursuing key research imperatives could make us all more successful. Discussing those potential next steps as a group was important and very inspiring. The Pipernos made that possible.” The Monaciano Symposium was designed to foster collaboration and the development of shared policy and research agendas. Participants defined five consensus goals needed to move the field forward in the next decade and eight actions that could be undertaken collaboratively to achieve those goals. The group aims to publish their findings in the coming year. That outcome is exactly what the Pipernos had in mind. Diagnosed with a retinal dystrophy many years ago, Mr. Piperno has a deep appreciation for the progress that is being made toward treatments and for

Researchers and physicians from seven countries participated in the Monaciano Symposium.

Tenuta di Monaciano (photos compliments of Richard Weleber, M.D., Casey Eye Institute)

the importance of global cooperation among scientists. Director of the Retinal Degeneration and Ophthalmic With strong ties to U-M — he earned a master’s degree Genetics Service at the University of Tennessee Health in business administration at U-M, Science Center. Researchers “This is a crucial time in retinal attended from eight states and and his children have attended seven countries. programs at the Ross School of degeneration research, and the Business — he and his wife ap“In this age of digital connecproached Paul R. Lichter, M.D., tions, there remains no substitute need for us to work together as for face-to-face interactions,” with the idea for a conference. The Pipernos provided lodgMr. Piperno says. “We hope the an international community has ing and meals for the Monaciano Monaciano meeting will be reSymposium, while the agenda was membered as a point for progress never been greater.” set by an organizing committee in establishing the etiology and that included Mr. Piperno’s course of treatment for retinal — Debra A. Thompson, Ph.D. diseases, and we look forward ophthalmologist, Alessandro to the continuation and growth of the symposium’s Iannaccone, M.D., M.S., who has a practice in Rome international dialogue.” and is Associate Professor of Ophthalmology and

Collaborating with a leader in

gene therapy and cell transplantation Robin Ali, BSc, PhD, FMedSci,

internationally known for his research in gene and cell-based therapy, will join the Department as a Visiting Professor. Dr. Ali, professor of human molecular genetics, directs the Department of Genetics at University College London and Moorfields Eye Hospital. While in residence at Kellogg, Dr. Ali will collaborate with faculty and trainees to advance research toward treatments for inherited retinal disease.

As just one example of his groundbreaking research, Dr. Ali led the team that carried out the first successful transplant of light-sensitive photoreceptor cells taken from a synthetic retina and grown “in a dish” from embryonic stem cells. The study, published in the August 2013 issue of Nature Biotechnology, suggests that embryonic stem cells could one day provide a potentially unlimited supply of healthy photoreceptors for retinal cell transplantations to treat blindness in humans. In addition to collaborating with faculty on research associated with retinal degenerations and inherited ocular diseases, Dr. Ali will mentor new faculty, trainees, and research staff in gene and cell therapy techniques. He will work with our faculty to generate sponsored research grants, and to bring the most promising research forward into clinical trials with the goal of developing new therapies for patients with retinal disease.

Endowed Professorship Honors Christine Nelson, M.D. Award provides Dr. Nelson the opportunity to advance her research in anophthalmia, a congenital eye birth defect in which one or both eyes do not develop

Department Chair Paul Lee, Dr. Christine Nelson, Mrs. Cheryl Frueh, and Medical School Dean James Woolliscroft

the gene mutation and deficiencies in the mother’s diet Oculoplastics surgeon Christine C. Nelson, M.D., has during pregnancy may be responsible for the disorder. been named the first Bartley R. Frueh, M.D. and Frueh “When the mother and fetus carry the gene, we believe Family Collegiate Professorship in Eye Plastics and that treatment with vitamin A early in the pregnancy Orbital Surgery. Dr. Nelson is Professor, Ophthalmolcould promote normal fetal ocular development,” says ogy and Visual Sciences, and Professor, Department of Dr. Nelson. “This is an exciting development with a Surgery, Plastic Surgery Section. relatively simple treatment that could have a global im Dr. Frueh and his wife, Cheryl, established the pact, improving the lives of individuals with a genetic Lloyd and Virginia Frueh Research Professorship in history of anophthalmia.” Eye Plastics and Orbital Surgery in May 2007. This Dr. Nelson also studies the related conditions of title was later changed to include Dr. (Bartley) Frueh’s microanophthalmia, in which one or both eyes are name in 2010, after he unexpectedly passed away. abnormally small, and coloboma, Establishing a professorship “Bartley was very passionate in which segments of tissue are in his parents’ names meant missing from various eye struca great deal to Dr. Frueh, as about research in the field of tures. Moreover, she is known for it created a lasting tribute to her clinical expertise in the evaluthe values of education, hard oculoplastics. He wanted to make ation and treatment of adult and work, and beneficence that pediatric patients with tumors they instilled in him. sure that this arena remained and other disorders of the eyelid “Bartley was very passionand orbital disease. ate about research in the field vital and strong at Kellogg.” “I am very humbled to be of oculoplastics. He wanted named the first Bartley R. Frueh, to make sure that this arena — Mrs. Cheryl Frueh M.D. and Frueh Family Colleremained vital and strong at giate Professorship in Eye Plastics and Orbital Surgery, Kellogg,” says Mrs. Frueh. “Both he and Paul [Paul an honor that will keep Dr. Frueh’s memory alive,” Lichter, Immediate Past Chair of the Department] says Dr. Nelson. “He was a great teacher and mentor had a vision to see the Department evolve into a to all of us at the Kellogg Eye Center. It was a privilege world-class entity in oculoplastics. The beauty is to know and work with him. His unmatched clinical that Bartley was able to see this take place at Kellogg and surgical skills, compassion, keen scientific intellect, while he was still alive.” and wonderful spirit will not be seen again soon.” Under this professorship, Dr. Nelson will have Dr. Nelson was also the first female recipient of more resources to devote to teaching, mentorship, and the prestigious Wendell Hughes Lectureship Award her research in anophthalmia, a condition in which one from the American Society of Ophthalmic and Plastic or both eyes do not develop. Through her study of a Reconstructive Surgery in 2012, and she joins a roster seven-generation family, Dr. Nelson and her colleagues of distinguished contributors to the advancement of have identified a new gene for this eye birth defect. ophthalmic plastic and reconstructive surgery. Her research findings suggest that the combination of 26

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With gratitude for gifts made from July 1, 2012, through June 30, 2013

Annual Honor Roll of Donors With heartfelt thanks to donors

Susan J. Lane Richard and Jane Manoogian THE RDH12 Fund for Sight Timothy and Laurie G. Wadhams Richard N. and Marilyn K. Witham

who made gifts from July 1, 2012,

$10,000 to $49,999

through June 30, 2013. Included in

American Diabetes Association, Inc. Bell Charitable Foundation Edward P. and Kathryn M. Bellas Trust Mary L. Boyers Trust Sandra and David Detrisac Ann A. Edwards Jacqueline A. Forrest Cheryl Terpening Frueh M. and H. Ghandour Al and Colette Kessel Drs. Vikas and Bithika Kheterpal Paul and Jennifer Lee William C. and Sally A. Martin The Meijer Foundation Larry G. Miller Bruce and Roberta Oliver Michael Pachtman James and Nancy Ravin Shirley M. Schaible Estate Mickey and Karen Shapiro Elmer and Sylvia Sramek Charitable Foundation Mildred E. Swanson Foundation Margaret F. Vezina Estate The Honorable Nancy C. Wheeler

this listing are contributors whose donations are part of multi-year pledges.

$1,000,000 and above W.K. Kellogg Foundation

$500,000 to $999,999 Edwin E. Meader Estate

$100,000 to $499,999 The Foundation Fighting Blindness Jerome Jacobson Foundation Juvenile Diabetes Research Foundation Roger W. Kittendorf, TTEE Philip J. Lo Presti Estate Research to Prevent Blindness Winifred A. Stedman Trust The Harry A. and Margaret D. Towsley Foundation

$50,000 to $99,999 Anonymous Donor (1) Thomas W. Breakey Frances and David H. Grossman W.R. Kenley Estate

$5,000 to $9,999 Michael and Joanne Bisson Cynthia L. and Jason M. Burgett, M.D.

Don and Betts Chisholm Scott M. Corin and Nina Blumenthal Jane and Irwin Deister, Jr. Joe and Beth Fitzsimmons Richard and Lisa Garfinkel Tarek S. Hassan and Diana M. Gomez Hassan Helen and Richard Kerr Carolyn R. and Paul R. Lichter Corey A. and Nancy J. Miller Gerald and Joyce Trocchio Danny D. Wang and Yili Wang W. Scott and Jill Wilkinson

$1,000 to $4,999 Gerald and Gloria Abrams Anthony and Mary Adamis Amjad Z. Ahmad, M.D. Anonymous Donors (2) Steven and Carol Archer Betty Baier and Mark Kesson Harry and Patricia Bash Anne and Terry J. Bergstrom Lana L. Berry Eleanor E. Brownell Michael J. Bueche, M.D. Bruce D. Cameron, M.D. Margaret Campbell Keith D. and Cheryl Carter Mark and Janet Cichowski Mark and Judith Cohen Claude M. Coleman Mr. Frank and Dr. Theresa Cooney Ruth E. Cressman Monte A. and Kristen G. Del Monte Rosemarie DeLand

“Contributions from Annual Fund donors will help us maintain our state-of-the-art confocal and multi-photon microscopes. Nearly every scientist at Kellogg uses these high-resolution instruments to obtain precisely detailed images of cells and tissue that are needed to advance our research on eye disease and treatment.” — David A. Antonetti, Ph.D.

Professor

Innovation in vision

With gratitude for gifts made from July 1, 2012, through June 30, 2013

“We are extremely grateful for donor support that has enabled us to develop “RetDegenDx,” a computer model to help us identify more precisely the causative mutations for patients with inherited retinal degenerations. By providing our patients with a genetic diagnosis, we can offer genetic counseling on the probable course of their disease and the likelihood that their siblings or children may be affected. And as gene therapies are developed, we can alert patients to clinical trials with treatments that target their specific mutation.” — Thiran Jayasundera, M.D.

Assistant Professor

J. McGregor and Christine Dodds Raymond and Jodi Douglas Michael and Elizabeth Eichler Hal and Donna Estry Gary and Kay Feaster Triford Foundation Margaret E. Gallup Janice Gault and James F. Vander, M.D. Larry and Mary Gerbens Mr. and Mrs. Waleed K. Gosaynie Joanne R. Gradowski Daniel and Norma Green Richard F. and Susan Gutow Kenneth Haller Theodore and Naomi Harrison David S. Hemmings, M.D. Myron Hepner Barry and Mary Ann Hoffman Robert O. and Carolyn S. Hoffman James and Kathy Holmes Walter L. and Barbara J. Hungerford Denise A. M. John, M.D. A. Timothy Johnson, M.D., Ph.D. James A. Johnson Professor Judy M. Judd Daniel and Rose Kachnowski Nancy and Jeffrey Kahn, M.D. Ann Novak-Krajcik and Joseph Krajcik, M.D. Kim Lindenmuth and Matthew Bueche William W. Love James Albert Maraldo Dr. and Mrs. P. Anthony Meza Joel and Susan Mindel Dean and Lynn Mitchell Ken and Pat Musson John P. and Ginger G. Myers Dr. Michel and Alice Nasif Pam W. Parrish Allen and Kathy Pearce Michael Petersen and Elizabeth Binasio Mark and Kimberly Phelan Jeffrey A. Pike Scott M. Pinter, M.D. Playoffs Sports Bar Donald and Debra Puro Dr. and Mrs. Alfred G. Shrosbree Dr. and Mrs. Gregory L. Skuta H. Kaz Soong and Barbara A. Nevins-Soong Peter K. and Faye B. Speert Mike Stolnack and Tina D. Turner Alan and Gail Sugar Bernard E. Sullivan James B. Thompson and Mary Ann Brandt Triford Foundation Richard L. and Kay E. Watnick

university of michigan kellogg eye center

Lee S. and Stephen T. Webster John and Carol Weigel George C. and Cindy Whitaker Marina V.N. and Robert F. Whitman Alfred and Carol Wick XI Chapter of Delta Gamma Foundation

$500 to $999 Roger D. Arnett Everton and Saundrett Arrindell Mrs. Jennie Biggs Duane and Jean Bingel Henry A. Boldt Trust James and Jacqueline Bowen Richard and Enid Carlin Anne M. Chase Michele Tameris Cook D & M Lumber Products Company, Inc. Roland and Louise W. DeMartin Roberta DeMott-Friberg Gayle D. Dickerson Dr. M. Kenneth and Arvene Dickstein Deborah Eadie Dr. John Fennig and Dr. Martha M. Wright Michael Fetters and Sayoko Moroi Dennis and Christine Fornal William F. Frederick Gianfranco Gabbianelli Harry C. Gibson, M.D. Kathryn G. Gray Geza L. and Elizabeth F. Gyorey Jane Hakken David J. Harris Mark and Mary Hetrick Millicent Higgins, M.D. Charles A. Hutton David A. and Patricia D. Johnson Michael A. and Kim M. Kipp James G. and Carolyn Knaggs Frank J. Konkel Professor Emeritus Myra A. Larson Richard Alan Lewis and Patricia N. Lewis Nancy E. and James E. MacVicar, M.D. Judge Joe B. McDade and Mrs. Mary W. McDade Mary L. Meyer Betsy and Ken Nisbet Pizza House Ann Arbor Hans H. and Virginia A. Rae Iva Jean Roe David A. Rogers Jonathan and Robin Rowe Drs. Michael and Mary Ruddat Perry and Faith Schechtman Donald and Jane Schriver Ted and Mary Ann Simon

With gratitude for gifts made from July 1, 2012, through June 30, 2013 Alma W. Smith James P. and Dorothy Symons Frank D. Tennent Thomas G. Varbedian, M.D. Drs. Adrienne West and Mark Hemmila Jung and Chiung Yao Wu

$100 to $499 Ann T. Alexander Kevin Alfonso Adeela Alizai and Asad Ansari Colonel and Mrs. Richard W. Anderschat Dr. Krista Anderson Jack and Mary Badalamenti Beverly and George Baker Lawrence A. Barnes Anne and Donald F. Baty, Jr. Stanley and Joy Berent Lois Bereza Dr. and Mrs. Werner G. Bergen Rhoda L. and Roger M. Berkowitz William and Patricia Berlin Cagri and Sheila Besirli Garry N. Binegar, M.D. Michael and Clarita Bishel Jonathan and Jill Bixler Gerald R. and Ann L. Black Donald and Georgia Boerma Myrtle B. Bonem Stephen and Danielle Boorstein Frances R. Bosel Daniel L. Braden William and Julie Bromley Gene Brown and Dee Oliverio Henry J. and Jean L. Brown Margaret Brown Arsenia Bumgardner Frederick G. and Marion F. Burgett Gregory L. and Marlene M. Burhans Wilbur and Carolyn Burkett Michael A. and Diana L. Burnstine Donald V. Calamia Norman and Maureen Campbell Arlene R. Caon James and Jennifer Carr J. R. and Elaine J. Carson Claudette J. Casello Dr. L. Ross Chambers Robert and Kay B. Chesebro Hideki and Tomomi Chuman Antonio and Elizabeth Ciciretto Marilyn Citron R. Kent Clark Martha and James Cleary Ms. Alice S. Cohen Dr. Clare R. Coles Carl and Maria Constant

Frank L. Cooper Patrick and Laura Coppens Ellen L. Coulthard Kim and Loraine J. Cranor MargaretAnn Cross and James Van Fleteren Roland and Susan Cull James and Marylyn Cumming William and Carol Cutler John and Elizabeth Dallas Dolores D. Daudt James E. Davies Prof. William and Virginia Dawson Joseph and Theresa DeMaria James R. Devine David J. Disser John A. Dodds Donald A. Dodick Mr. and Mrs. Kenneth R. Dornbrook Deborah Drous Jeanette R. Duckworth Mr. and Mrs. Wilbert L. Ehmann Jonathan Eisengart and Jodie Rich George Evans Blanche J. Felice Bryn A. and Suzanne M. Fick Bruce and Susan Furr Charles A. Gallup Michael J. Geiss, III, and Tina Taggart Jane and Robert Gelman Richard and Jacqueline Gilbert Lisa R. Gould Richard L. Greer Norman Grigsby Steven and Iris Haak Margaret Hagen Charlotte Hanson Noriko and Dr. Ken Hashimoto Gerald and Mignon Heppler Ruth Heyn, M.D. Conrad and Jeanne Heyner Dr. Frederick J. Heyner Tom S. Hill Peter J. Hirth Richard and Jane Hiss Timothy Hogan and Lindsey Wills Margaret M. and James E. Hughes Hull Brother’s Rental, Inc. Illinois Tool Works Foundation Richard and Anne Jackson Elizabeth L. Jacobs Mr. and Mrs. Kenneth B. Johnson Mark and Linda Johnson Reid and Donna Johnson Artie M. Jones Baerbel Juenger George H. and Jo A. Jury Ruth L. Kalin Ariane Kaplan and Adam Stein

“Due to the generous support of the W.K. Kellogg Foundation, we have the potential to decrease disparities in children's eye care across Michigan. The active collaborations we now have with the childhood vision screening programs conducted by the State of Michigan and the Lions Clubs of Michigan simply would not have happened without the Foundation’s pivotal and generous support. This serves to emphasize the impact of private donor support.” — David C. Musch, Ph.D., M.P.H

Professor

Innovation in vision

With gratitude for gifts made from July 1, 2012, through June 30, 2013 Jill Taft Kaufman Robert B. Kaufman, M.D. Rosemary S. Kaye Marianne and Mike Kessel Ralph and Priscilla Kinney Shirley D. Kline Donald L. Klopcic, Sr. Alexandra Klos Thomas C. and Mary J. Knight Theodore and Caroline Korn Drs. Teresa and Norman Krieger Susan and James Krucki Gerald and Dorothy Kurtz Marie Lane Louis and Gail LaRiche Kurt K. Lark, M.D., and Rebecca L. Lark, M.D. Dave H. and Peggy Lee Lucille Lefler Robert C. Leland, Jr. Gary Lelli and Kelly Bottger J. Paul and Cheryl L. Lemieux Jeanne M. Lerchen Danute M. Leveckis, M.D., and Timothy Van Every, M.D. Barbara R. Levine Giant C. Lin and Linda Zhang Sherry L. Lindahl Mark and Carol Loessel Uday Loka Thomas Longworth and Carol Cramer Joan Lowenstein and Jonathan Trobe Lonnie L. Loy Fred A. Lustig Michael and Donna Maddin Joseph L. Maggini Leo and Kathryn Maguire Richard and Barbara Mannis Marvin and Shirley Markgraff Eugene and Sandra Matsco

Regent Olivia P. Maynard and S. Olof Karlstrom Robert J. and Marilynn McDonald Professor and Mrs. Wilbert J. McKeachie Lloyd and Helen McKee Donald and Diane Meitz Mr. Somsak Metriyakool Herbert R. and Carolyn M. Metzger Laurie and Frederick Metzger Shahzad I. Mian and Uzma Ahmad William and Caroline Michaluk Steven J. Miller Helen L. Mitchell Ms. Marlene M. Moleski Peter Montana John and Linda Morrison Richard G. Mosteller Padmaja R. and Konda B. Mouli, M.D. William J. Mundus Alphonsus C. Murphy Stanley Nalepka Christine C. Nelson and Willis C. Lillard Catherine E. Nesbitt Gordon and Vernie Nethercut Harry and Leeta Nistel Paul Olson and MaryClare Denk Olson Mohammad and Elizabeth Othman Kazuo Otomo Mark E. and Barbara C. Overland Kishan Padakannaya Edmund and Elaine Palmer John and Sophie Papajohn Joseph and Betty Pavka Keith and Janet Lee Perkins Donald and Dorothy Peterson Pfizer Foundation James and Nancy Pflasterer

“Generous support from a donor has aided my research on rare, life-threatening eye cancers that might not otherwise receive sufficient public or federal grant support. With research findings to help us better understand and manage these eye cancers, we have the opportunity to improve patient outcomes.” — Hakan Demirci, M.D.

Associate Professor

university of michigan kellogg eye center

Luke R. and Joy M. Pinkerton Sheryl and Douglas Podlewski Larry and Maureen Potocki Rebecca and Eric Priebe Drs. Douglas and Leslie Quint Dr. Reza Rahmani and Mrs. Ellen F. Rahmani Anne and Robert Rapp Stephen and Penny Reck Mr. and Mrs. Walter F. Redmond Ann M. Reed William and Charlotte Rees Fred and Sharon Regula Christopher D. Reid Robert O. and Alice M. Reisig Charles S. Remenar Julie Reno Rita and Robert Reske Ms. Ann M. Rice G. Richard Rice Jean Richardson Amelie Riendl Barbara and Art Rocco Richard Z. and Edie W. Rosenfeld Rennie and Michael Roth Vicki L. Rothhaar Robert M. and Judith S. Rubin Robert T. and Marietta C. Samaras Michael and Jeanette Santalucia Drs. Edward M. and Virginia M. Sayles Donald R. and Barbara Scavarda Linda and Thomas Schalek Charles Schmitter and Allyn Ravitz Willard and Judith Schneider Eileen Schott John and Karen Schultz Marc Alan Schwartz Dr. Drusilla L. Scott Garrett R. and Emily K. Scott

With gratitude for gifts made from July 1, 2012, through June 30, 2013 David and Elvera Shappirio Charles Sherman Shore to Shore Community Federal Credit Union Kathleen A. Silverman Simons Foundation Kenneth S. Smith and Donna Geneseo Rosemary W. Smith Sue-Ellen Smith Becky and Doug Spaly John and Alexandra Starr Virginia E. Stein Peter and Louisa Stoll Dale D. Stordahl Thomas and Jane Stratford Joel Sugar and Anita Gerber Alan and Lori Summer

Wesley Szpunar Edward and Karen Tenner Christopher J. Thomas Edward Thornhil H. James Thrall A. Richard Tischler Prof. Nelly S. Ullman Ray and E. Jean Valley Yea-Yuan B. Van Egeren Ronald Vanderlugt Frank and Thelma Veres Sue Vitous Richard and Edith Wacksman Arthur and Shirley Wade Claudia M. Wagner David R. Wagner Thomas Walker

Ora Pescovitz, M.D., Executive Vice President for Medical Affairs

William K. Wallach Christian and Ella Weber Maureen Wegryn Cyrus R. and Susan C. Wellman Dr. and Mrs. William W. Wells James H. and Mary Anne Winter Jeneane Wise George E. Wittbrodt Rolf K. and Helen L. Wohnus Maria A. Woodward and Jeremy Wolfe Richard L. Wresche Ford L. Wright Michael B. and Kathleen M. Yang Prof. Emer. York-Peng E. Yao and Mrs. Cynthia C. Yao

Jean Birkhill, Dr. Raymond Douglas, and Fred Birkhill

Victors for Michigan, Victors for Vision Friends and supporters of the W.K. Kellogg Eye Center gathered to learn more about Victors for Michigan, the largest fundraising effort in University of Michigan history. The Kellogg Eye Center will play a key role in the U-M Health Systemâ&#x20AC;&#x2122;s campaign, which will be formally rolled out in April.

Dr. Paul Lee with Lisa Mower-Gandelot and Jon Gandelot

Innovation in vision

With gratitude for gifts made from July 1, 2012, through June 30, 2013 In Memory Of The Kellogg Eye Center is honored to have received gifts in memory of the following individuals: Mathew Alpern, Ph.D. Margaret J. Baier and John A. Baier Dr. Clifford J. Bedore Norbert Bereza Ruth F. Clarke Paul and Kate Coleman Robert F. Connally LeRoy Constant Birdie E. Cooper Dr. Ray Croasdale Mary P. DeLuca Patrick Dionise Harold F. Falls, M.D. Mr. Fleming Richard Foster F. Bruce Fralick, M.D. Bartley R. Frueh, M.D. Dana Shresta and Mrs. Gerulski Martin J. Glenday Robert I. Goldsmith, M.D. Henry E. Gray Dr. Hanan C. Heller David Herald Dr. Frank D. Johnson Dr. Abdul Samad Khan Adabelle R. Knief Gloria Koenig Dr. Myron Levine Susan Lichter Dad and Aunt Lu Mr. & Mrs. Louis E. Maggini Reba Marie McCann Dr. Agnes C. McMenemy Lamoine B. Metty Barb Meyer Charles Mule Corrine M. (Simpson) Olson Mary Lee Olson Richard Priebe Donald Prover Ruth K. Robins Carl D. Roe William C. Rogers Billie G. Rouches Valeri Samaras Julianna Simon Dr. Newel Smith Marvin Sorrell Lillian E. Taylor Florence M. Timmons Marilynn Varbedian Mr. George Vartanian Jeffrey B. Wehking

Vera Weinberg Elizabeth Wolner Dr. George J. Zissis

In Honor Of The following individuals were honored through gifts to the Kellogg Eye Center: James L. Adams, M.D. Terry J. Bergstrom, M.D., Professor Emeritus Jill E. Bixler, M.D. Michael Cumming Susy Dallas Hakan Demirci, M.D. Karen Gould and Gary Saretsky John R. Heckenlively, M.D. Miss Ida Lucy Iacobucci Inez and James Mark W. Johnson, M.D. Paul P. Lee, M.D., J.D. Paul R. Lichter, M.D. Roger F. Meyer, M.D. Mark Milazzo Sayoko E. Moroi, M.D., Ph.D. Emma Oâ&#x20AC;&#x2122;Farrell Jill Oversier Penporn Reck, M.D. Sandi Santoro Stephen J. Saxe, M.D. H. Kaz Soong, M.D. Carol L. Standardi, R.N. Alan Sugar, M.D. Clare Van Fleteren Rebecca A. Wu, M.D. David N. Zacks, M.D., Ph.D.

Bequests and Other Planned Gifts It is with deep gratitude that we recognize the following individuals for making the Kellogg Eye Center a part of their estate plans: Frank J. and Helga Arnold Nancy Bender Anne S. Benninghoff Edward Berger Rhoda L. and Roger M. Berkowitz Robert D. Biggs, M.D. Dr. Robert W. Browne Mrs. Andrea Clark Gloria P. and William E. Dean, Jr. Jacqueline A. Forrest Ralph M. Fox Helen A. (Poorbaugh) Freedman

university of michigan kellogg eye center

Larry and Mary Gerbens Conrad L. Giles Ed and Sue Gorney Ida Lucy Iacobucci Mrs. Harry Krashen Edward and Duffy Ladenberger Harry and Eva McGee Marvin Joseph and Beverly McKenney Bruce L. and Roberta Oliver Alvin Perkiss Sally J. Pryce Joanne A. Rackham Katherine M. Rackham Alice and Ronald Shankland E.H. Newel and Rosemary Smith Russell A. Stephens and Phyllis A. Capogna June Stover James B. Thompson and Mary Ann Brandt David and Jayne VerLee

Only those who gave their permission are included above. The Kellogg Eye Center greatly values our donors, and we make every effort to ensure the accuracy of the honor roll. Please call us at 734.763.0875 if you note any errors.

Faculty honors and recognition July 1, 2012 â&#x20AC;&#x201D; June 30, 2013

Steven F. Abcouwer, Ph.D. Editorial Board, American Journal of Physiology: Endocrinology & Metabolism Editorial Board, Journal of Clinical & Experimental Ophthalmology David A. Antonetti, Ph.D. Editorial Board, Tissue Barriers National Eye Institute Study Section, Diseases & Pathophysiology of the Visual System Jules and Doris Stein Professorship, Research to Prevent Blindness Steven M. Archer, M.D. Best Doctors in America American Association for Pediatric Ophthalmology and Strabismus Lifetime Achievement Award Arthur Stickle Lecturer in Pediatric Ophthalmology, Washington University Medical Center, St. Louis, MO Jill E. Bixler, M.D. Best Doctors in America Brenda L. Bohnsack, M.D., Ph.D. Career Development Award, Research to Prevent Blindness Grant M. Comer, M.D., M.S. Best Doctors in America Theresa M. Cooney, M.D. Delegate, Michigan State Medical Society Board, Michigan Society of Eye Physicians and Surgeons Wayne T. Cornblath, M.D. Best Doctors in America Education Liaison Committee, American Academy of Ophthalmology Monte A. Del Monte, M.D. Best Doctors in America Castle Connolly Top Doctors Member and Grant Reviewer, Scientific Advisory Committee, Knightâ&#x20AC;&#x2122;s Templar Eye Research Foundation, Schaumburg, IL Member, Editorial Committee for Pediatric Ophthalmology, Eye Wiki, American Academy of Ophthalmology Immediate Past Chair and Consultant, International Affairs Committee, Association for Pediatric Ophthalmology and Strabismus Chair of the Program Committee, American Orthoptic Council Hakan Demirci, M.D. Best Doctors in America

Raymond S. Douglas, M.D., Ph.D. Best Doctors in America Top Doctor, U.S. News & World Report The Orbit Society American Academy of Ophthalmology Achievement Award Susan G. Elner, M.D. Best Doctors in America Victor M. Elner, M.D., Ph.D. Best Doctors in America Top Doctor, U.S. News & World Report Keynote Speaker: 13th International Congress of Ophthalmology and Optometry China, Shanghai, China Jerome I. Finkelstein, M.D., FACS Best Doctors in America Patrice E. Fort, Ph.D. Academic Advisor, Ophthalmology Research: An International Journal Editorial Board, Journal of Clinical & Experimental Ophthalmology Bruce A. Furr, C.O., Ph.D. Editorial Board, American Orthoptic Journal Executive Committee and Board of Directors, American Association of Certified Orthoptists Christopher Gappy, M.D. Bylaws and Rules Committee, American Association for Pediatric Ophthalmology and Strabismus Thomas W. Gardner, M.D., M.S. Best Doctors in America Associate Editor, Diabetes Director, Michigan Vision Clinician-Scientist Development Program Reviewer, Diabetes Complications Consortium, National Institutes of Health John R. Heckenlively, M.D. Best Doctors in America J. Donald Gass Award and Lecture, Ophthalmic Photographer Society Associate Editor, EYE, Journal of the Royal College of Ophthalmologists, U.K. Peter F. Hitchcock, Ph.D. Editorial Board, Academic Editor, PLoS ONE K. Thiran Jayasundera, M.D., FACS, FRCSC, FRANZCO Associate Editor, BMC Ophthalmology Denise A. John, M.D., FRCSC Representative, Association of American Medical Colleges Minority Faculty Career Development Seminar

Innovation in vision

Faculty honors and recognition July 1, 2012 â&#x20AC;&#x201D; June 30, 2013

Mark W. Johnson, M.D. Best Doctors in America 64th Proctor Lecture, University of California San Francisco, San Francisco, CA Gass Fluorescein Club Keynote Speaker, North Coast Retina Symposium, Cole Eye Institute, Cleveland, OH Chair, Committee on Programs, American Ophthalmological Society Treasurer and Executive Committee, The Retina Society Editorial Board, American Journal of Ophthalmology Editorial Board, Retina Editorial Board, Retinal Physician Alon Kahana, M.D., Ph.D. Best Doctors in America American Academy of Ophthalmology Achievement Award Editorial Board Member, Ocular Surgery News American Academy of Ophthalmology, Editorial Committee for the Basic and Clinical Science Course, Section 2 Book Revision Paul P. Lee, M.D., J.D. Best Doctors in America John Aure Buesseler, M.D., Visiting Professorship, Mason Eye Institute, University of Missouri Joseph Bowlds Lecture, Lahey Hospital and Medical Center, Burlington, MA Focus on Eye Health National Summit, Prevent Blindness America Doheny Society of Scholars Award Board of Directors, American Board of Ophthalmology Board of Governors, Association for Research in Vision Ophthalmology Foundation Board of Directors, Doheny Eye Institute Editorial Board, JAMA Ophthalmology Advisory Board, American Academy of Ophthalmology, Hoskins Center for Patient Safety and Quality Paul R. Lichter, M.D., FACS Best Doctors in America Board of Trustees, International Council of Ophthalmology President, Academia Ophthalmologica Internationalis Associate Editor, American Journal of Ophthalmology Board of Directors, Foundation of the International Council of Ophthalmology Michael J. Lipson, O.D., FAAO Advisory Board Member, Rigid Gas Permeable Lens Institute

university of michigan kellogg eye center

Shahzad I. Mian, M.D. Best Doctors in America Program Directorâ&#x20AC;&#x2122;s Council, Association of University Professors in Ophthalmology Board of Directors, Cornea Society American Academy of Ophthalmology, Councilor, Cornea Program Committee Ophthalmology Leadership Advocacy Group Medical Director, Michigan-Eye Bank Editorial Board, Cornea Journal Policy and Position Review Committee Chair, Accreditation Board, Eyebank Association of America Ralph & Sophie Heintz Lecture, The 38th Annual H. Bruce Ostler Association of Proctor Fellows Meeting and Graduation Albert D. Frost Memorial Lecture, The 56th Annual Postgraduate Symposium in Ophthalmology, Columbus, Ohio Sayoko E. Moroi, M.D., Ph.D. Best Doctors in America Best Paper of Glaucoma Session, American Society of Cataract and Refractive Surgery, San Francisco, CA Glaucoma Subcommittee, National Eye Health Education Program Planning Committee, National Institutes of Health, Bethesda, MD Ad Hoc Member, Diseases and Pathophysiology of the Visual System Study Section, National Eye Institute Ad Hoc Member, Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section, National Eye Institute Member, American Academy of Ophthalmology, Glaucoma Preferred Practice Pattern Committee David C. Musch, Ph.D., M.P.H. Secretariat Award, American Academy of Ophthalmology Member, Preferred Practice Patterns Committee, American Academy of Ophthalmology Member, Ophthalmic Technology Assessment Committee, American Academy of Ophthalmology Study Section (clinical trials special emphasis panel), National Institutes of Health/National Eye Institute Grant reviewer, Health and Medical Research Fund, Government of Hong Kong Editorial Board, Ophthalmology Editorial Board, Retina Christine C. Nelson, M.D., FACS Best Doctors in America Beard Award Lecturer, American Society of Ophthalmic Plastic and Reconstructive Surgery Wendell Hughes Lecturer Award, American Society of Ophthalmic Plastic and Reconstructive Surgery Media Advisory Task Force, American Academy of Ophthalmology Basic and Clinical Science Course, Book 7, American Academy of Ophthalmology Committee

Faculty honors and recognition July 1, 2012 — June 30, 2013

Donald G. Puro, M.D., Ph.D. Best Doctors in America Julia E. Richards, Ph.D. Winner, National Eye Institute Audacious Goals Challenge. Proposal: Fountains of Youth for the Eye Editorial Board, G3: Genes/Genomics/Genetics Member, National Eye Institute-funded Glaucoma Human Collaboration Consortium Member, African-American Study Group Consortium Member, Scientific Advisory Board, The Glaucoma Foundation, New York, NY Roni M. Shtein, M.D., M.S. Best Doctors in America American Academy of Ophthalmology Achievement Award Resident Retreat Faculty Mentor, Heed Ophthalmic Foundation Terry J. Smith, M.D. Best Doctors in America Board of Scientific Advisors, Guthy-Jackson Foundation Board of Directors, National Graves’ Disease Foundation Chief Medical and Scientific Officer, National Graves’ Disease Foundation Michael W. Smith-Wheelock, M.D. Best Doctors in America H. Kaz Soong, M.D. Best Doctors in America Assistant Editor, Cornea American Academy of Ophthalmology Lifetime Achievement Award Medical Director, Michigan Eye Bank Keynote Speaker, Taiwan Ophthalmological Society Joshua D. Stein, M.D., M.S. Best Doctors in America American Ophthalmological Society American Academy of Ophthalmology Achievement Award American Glaucoma Society Health Care Policy and Reimbursement Policy Subcommittee Member-at-Large, American Glaucoma Society Board of Directors Research Committee, American Glaucoma Society Membership Committee, American Glaucoma Society Committee Member, American Academy of Ophthalmology, Glaucoma Preferred Practice Patterns Research to Prevent Blindness Physician-Scientist Award

Alan Sugar, M.D. Best Doctors in America Editor-in-Chief, Cornea, Journal of the Cornea Society National Institutes of Health Study Section, Ad Hoc, Bioengineering of Neuroscience, Vision and Low Vision Technology Editorial Board, Ophthalmology Medical Director, Michigan Eye Bank Eye Bank Association of America Research Committee, Paton Award Committee Debra A. Thompson, Ph.D. Executive Editor, Experimental Eye Research Fellow, Association for Research in Vision and Ophthalmology Susan S. Thoms, M.D. Best Doctors in America Jonathan D. Trobe, M.D. Best Doctors in America Joshua P. Vrabec, M.D. Best Doctors in America Jennifer S. Weizer, M.D. Best Doctors in America Member, American Academy of Ophthalmology Cataract Registry Workgroup, San Francisco, CA Member, American Academy Ophthalmology Committee on Resident Education, San Francisco, CA Maria A. Woodward, M.D. Basic and Clinical Science Course Committee, American Academy of Ophthalmology David N. Zacks, M.D., Ph.D. Best Doctors in America Member, Retina/Vitreous Knowledge Base Panel, American Academy of Ophthalmology * Listings are limited to national and international awards, named lectures, and roles in professional societies or editorial boards. Only national peer-selected “Best Doctors” and “Top Doctors” rankings are noted

Innovation in vision

Faculty publications July 1, 2012 — June 30, 2013

Abcouwer SF, Antonetti DA. A role for systemic inflammation in diabetic retinopathy. Invest Ophthalmol Vis Sci. 2013 Mar;54(3):2384. Abcouwer SF. Direct effects of PPARα agonists on retinal inflammation and angiogenesis may explain how fenofibrate lowers risk of severe proliferative diabetic retinopathy. Diabetes. 2013 Jan;62(1):36-8. Al Alam D, Sala FG, Baptista S, Galzote R, Danopoulos S, Tiozzo C, Gage P, Grikscheit T, Warburton D, Frey MR, Bellusci S. FGF9-Pitx2-FGF10 signaling controls cecal formation in mice. Dev Biol. 2012 Sep;369(2):340-8. Albertus DL, Schachar IH, Zahid S, Elner VM, Demirci H, Jayasundera KT. Autofluorescence quantification of benign and malignant choroidal nevomelanocytic tumors. JAMA Ophthalmol. 2013 Jun 20:1-5. Allexan SS, Byington CL, Finkelstein JI, Tarini BA. Blindness in Walnut Grove: How did Mary Ingalls lose her sight? Pediatrics. 2013 Mar;131(4):404-6. Archer SM. Are amblyopia treatments really all equal? Is that even the right question? Am Orthopt J. 2012;62:1-3. Benetz BA, Lass JH, Gal RL, Sugar A, Menegay H, Dontchev M, Kollman C, Beck RW, Mannis MJ, Holland EJ, Gorovoy M, Hannush SB, Bokosky JE, Caudill JW. Endothelial morphometric measures to predict endothelial graft failure after penetrating keratoplasty. JAMA Ophthalmol. 2013 Mar 14:1-8. Besirli CG, Elner SG. Retinal vasculitis in Toxocara canis neuroretinitis. J Ophthalmic Inflamm Infect. 2013 Jan;3(1):1-3.

Besirli CG, Zheng QD, Reed DM, Zacks DN. ERK-mediated activation of Fas apoptotic inhibitory molecule 2 (Faim2) prevents apoptosis of 661W cells in a model of detachment-induced photoreceptor cell death. PLoS One. 2012 Sep;7(9):e46664. Bohnsack BL, Freedman SF. Surgical outcomes in childhood uveitic glaucoma. Am J Ophthalmol. 2013 Jan;155(1):134-42. Bohnsack BL, Kahana A. Thyroid hormone and retinoic acid interact to regulate zebrafish craniofacial neural crest development. Dev Biol. 2013 Jan;373(2):300-9. Branham KE, Othman M, Brumm M, Karoukis AJ, Atmaca-Sonmez P, Yashar BM, Schwartz SB, Stover NB, Trzupek K, Wheaton D, Jennings B, Ciccarelli ML, Jayasundera KT, Lewis RA, Birch D, Bennett J, Sieving PA, Andreasson S, Duncan JL, Fishman GA, Iannaccone A, Weleber RG, Jacobson SG, Heckenlively JR, Swaroop A. Mutations in RPGR and RP2 account for 15% of males with simplex retinal degenerative disease. Invest Ophthalmol Vis Sci. 2012 Dec;53(13):8232-7. Branham KE, Yashar BM. Providing comprehensive genetic-based ophthalmic care. Clin Genet. 2013 Aug;84(2):183-9. Epub 2013 Jun 5. Bressler NM, Chang TS, Varma R, Suner I, Lee PP, Dolan CM, Ward J, Ianchulev T, Fine J. Driving ability reported by neovascular age-related macular degeneration patients after treatment with ranibizumab. Ophthalmology. 2013 Jan;120(1):160-8. Briceño CA, Gupta S, Douglas RS. Advances in the management of thyroid eye disease. Int Ophthalmol Clin. 2013 Summer;53(3):93-101.

university of michigan kellogg eye center

Chen C, Thompson DA, Koutalos Y. Reduction of all-trans-retinal in vertebrate rod photoreceptors requires the combined action of RDH8 and RDH12. J Biol Chem. 2012 Jul;287(29):24662-70. Chen SK, Chew KS, McNeill DS, Keeley PW, Ecker JL, Mao BQ, Pahlberg J, Kim B, Lee SC, Fox MA, Guido W, Wong KY, et al. Apoptosis regulates ipRGC spacing necessary for rods and cones to drive circadian photoentrainment. Neuron. 2013 Feb 6;77(3):503-15. Chi SL, Acquah KF, Richard MJ, Lee PP, Sloan FA. Longitudinal evidence on punctal plug use in an elderly population. Ophthal Plast Reconstr Surg. 2012 Jul-Aug;28(4):289-93. Chinskey ND, Cornblath WT. Inferior oblique myokymia: A unique ocular motility disorder. JAMA Ophthalmol. 2013 Mar 1;131(3):404-5. Chou CF, Zhang X, Crews JE, Barker LE, Lee PP, Saaddine JB. Impact of geographic density of eye care professionals on eye care among adults with diabetes. Ophthalmic Epidemiol. 2012 Dec;19(6):340-9. Churchill JD, Bowne SJ, Sullivan LS, Lewis RA, Wheaton DK, Birch DG, Branham KE, Heckenlively JR, Daiger SP. Mutations in the X-linked retinitis pigmentosa genes RPGR and RP2 found in 8.5% of families with a provisional diagnosis of autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2013 Feb;54(2):1411-6. Day S, Acquah K, Platt A, Lee PP, Mruthyunjaya P, Sloan FA. Association of vitamin D deficiency and age-related macular degeneration in medicare beneficiaries. Arch Ophthalmol. 2012 Aug;130(8):1070-1.

Faculty publications July 1, 2012 — June 30, 2013

De Lott LB, Trobe JD, Parmar H. Restricted diffusion of the superior and inferior ophthalmic veins in cavernous sinus thrombosis. J Neuroophthalmol. 2013 Sep;33(3):268-70. Epub 2013 May 29. Eggenberger E, Cornblath WT. “Blinding” empty sella. Arch Neurol. 2012 Aug;69(8):1083-4. Fante RJ, Shtein RM, Titus MS, Woodward MA. Anterior segment optical coherence tomography versus ultrasound pachymetry to measure corneal thickness in endothelial keratoplasty donor corneas. Cornea. 2013 May;32(5):e79-82. Farjo AA, Sugar A, Schallhorn SC, Majmudar PA, Tanzer DJ, Trattler WB, Cason JB, Donaldson KE, Kymionis GD. Femtosecond lasers for LASIK flap creation: A report by the American Academy of Ophthalmology. Ophthalmology. 2013 Mar;120(3):e5-20. Field MG, Comer GM, Kawaji T, Petty HR, Elner VM. Noninvasive imaging of mitochondrial dysfunction in dry agerelated macular degeneration. Ophthalmic Surg Lasers Imaging. 2012 SepOct;43(4):358-65. Fox TE, Young MM, Pedersen MM, Han X, Gardner TW, Kester M. Diabetes diminishes phosphatidic acid in the retina: A putative mediator for reduced mTOR signaling and increased neuronal cell death. Invest Ophthalmol Vis Sci. 2012 Oct;53(11):7257-67. Fritsche LG, Chen W, Schu M, Yaspan BL, Yu Y, Thorleifsson G, Zack DJ, Arakawa S ...Branham KE...Heckenlively JR, et al. Seven new loci associated with age-related macular degeneration. Nat Genet 2013 Apr;45(5):433-9.

Gillespie EF, Raychaudhuri N, Papageorgiou KI, Atkins SJ, Lu Y, Charara LK, Mester T, Smith TJ, Douglas RS. Interleukin-6 (IL-6) production in CD40-engaged fibrocytes in thyroidassociated ophthalmopathy: Involvement of Akt and NF-kappaB. Invest Ophthalmol Vis Sci. 2012 Nov;53(12):7746-53. Goldstein JE, Massof RW, Deremeik JT, Braudway S, Jackson ML, Kehler KB, Primo SA, Sunness JS; Low Vision Research Network Study Group. Baseline traits of low vision patients served by private outpatient clinical centers in the United States. Arch Ophthalmol 2012 Aug;130(8):1028-37. [Wicker DM, Day SH - Collaborators] Greene JB, Mian SI. Cataract surgery in patients with corneal disease. Curr Opin Ophthalmol. 2013 Jan;24(1):9-14. Gupta S, Briceño CA, Douglas RS. Customized minimally invasive orbital decompression for thyroid eye disease. Expert Review of Ophthalmology. 2013 Jun;8(3):255-66. Hahn P, Acquah K, Cousins SW, Lee PP, Sloan FA. Ten-year incidence of agerelated macular degeneration according to diabetic retinopathy classification among Medicare beneficiaries. Retina. 2013 May;33(5):911-9. Harris Nwanyanwu KM, De Lott LB, Cornblath WT, Elner VM. Transient monocular vision loss due to churg-strauss syndrome vasculitis. JAMA Ophthalmol. 2013 Jan;131(1):117-9. Hood CT, Krueger RR, Wilson SE. The association between femtosecond laser flap parameters and ocular aberrations after uncomplicated custom myopic LASIK. Graefes Arch Clin Exp Ophthalmol. 2013 Sep;251(9):2155-62. Epub 2013 Apr 9.

Hood CT, Shtein RM, Mian SI, Sugar A. Neodymium-yttrium-aluminum-garnet laser lysis of retained cortex after phacoemulsification cataract surgery. Am J Ophthalmol. 2012 Nov;154(5):808-13. Hu C, Hill DD, Wong KY. Intrinsic physiological properties of the five types of mouse ganglion-cell photoreceptors. J Neurophysiol. 2013 Apr;109(7):187689. Igo RP Jr, Kopplin LJ, Joseph P, Truitt B, Fondran J, Bardenstein D, Aldave AJ, et al. FECD Genetics Multi-Center Study Group. Differing roles for TCF4 and COL8A2 in central corneal thickness and Fuchs endothelial corneal dystrophy. PLoS One. 2012 Oct;7(10):e46742. [Soong HK, Sugar A, Mian SI - Collaborators] Johnson MW. Conclusion. Retina. 2012 Sep;32 Suppl 2:S232. Johnson MW. How should we release vitreomacular traction: Surgically, pharmacologically, or pneumatically? Am J Ophthalmol. 2013 Feb;155(2):203-5 e1. Johnson MW. Myopic traction maculopathy: Pathogenic mechanisms and surgical treatment. Retina. 2012 Sep;32 Suppl 2:S205-10. Johnson MW. Posterior vitreous detachment: Evolution and role in macular disease. Retina. 2012 Sep;32 Suppl 2:S174-8. Kahana A, Lee BJ, Flint A, Elner VM. Periocular epithelioid hemangioma: Response to bevacizumab and vascular pathogenesis. Arch Ophthalmol. 2012 Sep;130(9):1209-12. Kalyani PS, Chinskey N, Schneider E, Besirli CG, Zacks DN. Intraocular tooth. JAMA Ophthalmol. 2013 Feb;131(2):241.

Innovation in vision

Faculty publications July 1, 2012 — June 30, 2013

Kassa E, Elner VM, Moroi SE, Sun Y. Diffuse Berlin nodules: Unusual presentation of ocular sarcoidosis. Br J Ophthalmol. 2013 Sep;97(9):1214. Epub 2013 May 31. Kaufman SC, Jacobs DS, Lee WB, Deng SX, Rosenblatt MI, Shtein RM. Options and adjuvants in surgery for pterygium: A report by the American Academy of Ophthalmology. Ophthalmology. 2013 Jan;120(1):201-8. Keil JM, Liu X, Antonetti DA. Glucocorticoid induction of occludin expression and endothelial barrier requires transcription factor p54 NONO. Invest Ophthalmol Vis Sci. 2013 Jun;54(6):4007-15. Kempen JH, Sugar EA, Jaffe GJ, Acharya NR, Dunn JP, Elner SG, Lightman SL, Thorne JE, Vitale AT, Altaweel MM. Fluorescein angiography versus optical coherence tomography for diagnosis of uveitic macular edema. Ophthalmology. 2013 Sep;120(9):1852-9. Epub 2013 May 21. Krom MM, Zacks DN, Vrabec JP. Late-onset cystoid macular edema as a presenting symptom of anca-negative pauciimmune crescentic glomerulonephritis. Retinal cases & brief reports. 2012 Fall;6(4):368-70. Kron M, Bohnsack BL, Archer SM, McHugh JB, Kahana A. Recurrent orbital schwannomas: clinical course and histopathologic correlation. BMC Ophthalmol. 2012 Aug;12(1):44. Kymes SM, Lambert DL, Lee PP, Musch DC, Siegfried CJ, Kotak SV, Stwalley DL, Fain J, Johnson C, Gordon MO. The development of a decision analytic model of changes in mean deviation in people with glaucoma: The COA model. Ophthalmology. 2012 Jul;119(7):1367-74.

Laird PW, Woodward MA, Williams JG, Lee WB, Grossniklaus HE. Cystic benign melanosis of the conjunctiva. Cornea. 2012 Nov;31(11):1273-7 Lee BJ, Nelson CC, Lewis CD, Perry JD. External dacryocystorhinostomy surgery in patients with Wegener granulomatosis. Ophthal Plast Reconstr Surg. 2012 NovDec;28(6):389-92. Lee PP, West SK, Block SS. Surveillance of disparities in vision and eye health in the United States: An expert panel’s opinions. Am J Ophthalmol. 2012 Dec;154(6 suppl):S3-S7. Leinberger RL, Janz NK, Musch DC, Niziol LM, Gillespie BW. Discussing driving concerns with older patients: I. vision care providers’ attitudes and behaviors. JAMA Ophthalmol 2013 Feb;131(2):205-12. Lichter PR, Bartley GB. Interview with Paul R. Lichter, MD. Arch Ophthalmol. 2012 Sep;130(9):1205-6. Lott ME, Slocomb JE, Shivkumar V, Smith B, Gabbay RA, Quillen D, Gardner TW, Bettermann K. Comparison of retinal vasodilator and constrictor responses in type 2 diabetes. Acta Ophthalmol. 2012 Sep;90(6):e434-41. Lott ME, Slocomb JE, Shivkumar V, Smith B, Quillen D, Gabbay RA, Gardner TW, Bettermann K. Impaired retinal vasodilator responses in prediabetes and type 2 diabetes. Acta Ophthalmol 2013 Sep;91(6):e462-9. Epub 2013 Jun 7. Lu Y, Vitart V, Burdon KP, Khor CC, Bykhovskaya Y, Mirshahi A, Hewitt AW ...Richards JE, Moroi SE, et al. Genomewide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Nat Genet. 2013 Feb;45(2):155-63.

university of michigan kellogg eye center

Luo J, Uribe RA, Hayton S, Calinescu AA, Gross JM, Hitchcock PF. Midkine-A functions upstream of Id2a to regulate cell cycle kinetics in the developing vertebrate retina. Neural Dev. 2012 Oct;7(1):33. Marmor MF, Chien FY, Johnson MW. Value of red targets and pattern deviation plots in visual field screening for hydroxychloroquine retinopathy. Arch Ophthalmol. 2013 Apr;131(4):476-80. Mendoza-Reinoso V, Patil TS, GuevaraFujita ML, Fernandez S, Vargas E, CastilloHerrera W, Perez-Grossmann R, LizarasoCaparo F, Richards JE, Fujita R. Novel and known MYOC exon 3 mutations in an admixed Peruvian primary open-angle glaucoma population. Mol Vis. 2012 Aug 8;18:2067-75. Mets MB, Rich WL, Lee PP, Schuman JS, Wilson D, Chew E, Buckley E. The Ophthalmic Practice of the Future. Arch Ophthalmol 2012 Sep;130(9):1195-8. Mizrachi IB, Trobe JD. [Cavernous hemangioma of anterior visual pathways — a rare cause of visual loss]. Harefuah. 2013 Feb;152(2):92-7, 123. Muir KW, Gupta C, Gill P, Stein JD. Accuracy of international classification of diseases, ninth revision, clinical modification billing codes for common ophthalmic conditions. JAMA Ophthalmol. 2013 Jan;131(1):119-20. Musch DC, Gardner TW. Diabetes and nonrefractive visual impairment: The young have it. JAMA. 2012 Dec;308(22):2403-4. Musch DC, Janz NK, Leinberger RL, Niziol LM, Gillespie BW. Discussing driving concerns with older patients: II. vision care providers’ approaches to assessment. JAMA Ophthalmol. 2013 Feb;131(2):213-8.

Faculty publications July 1, 2012 â&#x20AC;&#x201D; June 30, 2013

Musch DC, Shimizu T, Niziol LM, Gillespie BW, Cashwell LF, Lichter PR. Clinical characteristics of newly diagnosed primary, pigmentary and pseudoexfoliative open-angle glaucoma in the Collaborative Initial Glaucoma Treatment Study. Br J Ophthalmol. 2012 Sep;96(9):1180-4. Newman-Casey PA, Weizer JS, Heisler M, Lee PP, Stein JD. Systematic review of educational interventions to improve glaucoma medication adherence. Semin Ophthalmol. 2013 May;28(3):191-201. Niziol LM, Musch DC, Gillespie BW, Marcotte LM, Sugar A. Long-term outcomes in patients who received a corneal graft for keratoconus between 1980 and 1986. Am J Ophthalmol. 2013 Feb;155(2):213-9.e3. Nwanyanwu KH, Comer GM, Demirci H. Presumed choroidal metastasis secondary to clear cell sarcoma of the right knee. Int Ophthalmol. 2013 Apr;33(2):163-5. Harris Nwanyanwu K, Talwar N, Gardner TW, Wrobel JS, Herman WH, Stein JD. Predicting development of proliferative diabetic retinopathy. Diabetes Care 2013 Jun;36(6):1562-8. Ou Y, Grossman DS, Lee PP, Sloan FA. Glaucoma, Alzheimer disease and other dementia: a longitudinal analysis. Ophthalmic Epidemiol. 2012 Oct;19(5):285-92. Padmaja S, Cornblath WT. Oculopalatal tremor in multiple sclerosis with spontaneous resolution. Neurol Clin Pract. 2012 Sep;2(3):255-57. Pasquale LR, Loomis SJ, Kang JH, Yaspan BL, Abdrabou W, Budenz DL, Chen TC ...Lichter PR, Liu Y, McCarty CA, Moroi SE...Richards JE, Haines JL, Wiggs JL. CDKN2B-AS1 Genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States. Am J Ophthalmol. 2013 Feb;155(2):342-53.

Paz SH, Slotkin J, McKean-Cowdin R, Lee PP, Owsley C, Vitale S, Varma R, Gershon R, Hays RD. Development of a vision-targeted health-related quality of life item measure. Qual Life Res. Epub 2013 Mar 9. Peeler C, Parmar H, Trobe JD. Subretinal abscess causing restricted diffusion on magnetic resonance imaging. J Neuroophthalmol. Epub 2013 Jun 18. Ple-Plakon PA, Demirci H, Cheng JX, Elner VM. Orbital myeloid sarcoma in an adult with acute myeloid leukemia, FAB M1, and 12p- deletion. Ophthal Plast Reconstr Surg. 2013 May-June;29(3):e73-5. Prabhu SS, Kaakeh R, Sugar A, Smith DG, Shtein RM. Comparative cost-effectiveness analysis of descemet stripping automated endothelial keratoplasty versus penetrating keratoplasty in the United States. Am J Ophthalmol. 2013 Jan;155(1):45-53. Rumery TC, Mian SI. Ocular graft vs. host disease after hematopoietic stem cell transplantation. Insight. 2013 Winter;38(1):11-8. Runkle EA, Rice SJ, Qi J, Masser D, Antonetti DA, Winslow MM, Mu D. Occludin is a direct target of thyroid transcription factor-1 (TTF-1/NKX2-1). J Biol Chem. 2012 Aug;287(34):28790-801. Schachar IH, Zahid S, Comer GM, Stem M, Schachar AG, Saxe SJ, Gardner TW, Elner VM, Jayasundera KT. Quantification of fundus autofluorescence to detect disease severity in nonexudative agerelated macular degeneration. JAMA Ophthalmol. 2013 Aug;131(8):1009-15. Epub 2013 Jun 20.

Schneider EW, Elner SG, van Kuijk FJ, Goldberg N, Lieberman RM, Eliott D, Johnson MW. Chronic retinal necrosis: Cytomegalovirus necrotizing retinitis associated with panretinal vasculopathy in non-HIV patients. Retina. 2013 Oct;33(9):1791-9 . Epub 2013 April 16. Shelby SJ, Colwill K, Dhe-Paganon S, Pawson T, Thompson DA. MERTK interactions with SH2-domain proteins in the retinal pigment epithelium. PLoS One. 2013 Feb;8(2):e53964. Shi D, Funayama T, Mashima Y, Takano Y, Shimizu A, Yamamoto K, Mengkegale M, Miyazawa A, Yasuda N, Fukuchi T, Abe H, Ideta H, Nishida K, Nakazawa T, Richards JE, Fuse N. Association of HK2 and NCK2 with normal tension glaucoma in the Japanese population. PLoS One. 2013 Jan;8(1):e54115. Shtein RM, Callaghan BC. Corneal confocal microscopy as a measure of diabetic neuropathy. Diabetes. 2013 Jan;62(1):25-6. Shtein RM, Michelotti MM, Kaplan A, Mian SI. Association of surgeon experience with outcomes of femtosecond LASIK. Ophthalmic Surg Lasers. Imaging 2012 Nov-Dec;43(6):489-94. Shtein RM, Raoof-Daneshvar D, Lin HC, Sugar A, Mian SI, Nan B, Stein JD. Keratoplasty for corneal endothelial disease, 2001-2009. Ophthalmology. 2012 Jul;119(7):1303-10. Shtein RM, Raoof-Daneshvar D, Lin HC, Sugar A, Mian SI, Nan B, Stein JD. Author reply. Ophthalmology. 2013 Mar;120(3):650-1 Smith TJ. Is IGF-I receptor a target for autoantibody generation in Gravesâ&#x20AC;&#x2122; disease? J Clin Endocrinol Metab. 2013 Feb;98(2):515-8.

Innovation in vision

Faculty publications July 1, 2012 â&#x20AC;&#x201D; June 30, 2013

Soong HK, de Melo Franco R. Anterior chamber gas bubbles during femtosecond laser flap creation in LASIK: Video evidence of entry via trabecular meshwork. J Cataract Refract Surg. 2012 Dec;38(12):2184-5.

Stem MS, Talwar N, Comer GM, Stein JD. A longitudinal analysis of risk factors associated with central retinal vein occlusion. Ophthalmology. 2013 Feb;120(2):362-70.

Spielberg LH, Heckenlively JR, Leys AM. Retinal pigment epithelial detachments and tears, and progressive retinal degeneration in light chain deposition disease. Br J Ophthalmol. 2013 May;97(5):627-31.

Stulting RD, Sugar A, Beck R, Belin M, Dontchev M, Feder RS, Gal RL, Holland EJ, Kollman C, Mannis MJ, Price F, Jr., Stark W, Verdier DD. Effect of donor and recipient factors on corneal graft rejection. Cornea. 2012 Oct;31(10):1141-7.

Stein JD, Childers DM, Nan B, Mian SI. Gauging interest of the general public in laser-assisted in situ keratomileusis eye surgery. Cornea. 2013;32(7):1015-8.

Sudhakar P, Parmar H, Cornblath WT. Oculopalatal tremor in multiple sclerosis with spontaneous resolution. Neurol Clin Pract. 2012 Sep;2(3):255-7.

Stein JD, Hanrahan BW, Comer GM, Sloan FA. Diffusion of technologies for the care of older adults with exudative age-related macular degeneration. Am J Ophthalmol. 2013 Apr;155(4):688-96.

Sudhakar P, Trobe JD, Wesolowski J. Dural puncture-induced intracranial hypotension causing diplopia. J Neuroophthalmol. 2013 Jun;33(2):106-12.

Stein JD, Newman-Casey PA, Kim DD, Nwanyanwu KH, Johnson MW, Hutton DW. Cost-effectiveness of various interventions for newly diagnosed diabetic macular edema. Ophthalmology. 2013 Sep;120(9):1835-42. Epub 2013 May 1. Stein JD, Newman-Casey PA, Talwar N, Nan B, Richards JE, Musch DC. The relationship between statin use and open-angle glaucoma. Ophthalmology. 2012 Oct;119(10):2074-81. Stein JD, Niziol LM, Musch DC, Lee PP, Kotak SV, Peters CM, Kymes SM. Longitudinal trends in resource use in an incident cohort of open-angle glaucoma patients: Resource use in open-angle glaucoma. Am J Ophthalmol. 2012 Sep;154(3):4529 e2. Stein JD, Talwar N, Laverne AM, Nan B, Lichter PR. Racial disparities in the use of ancillary testing to evaluate individuals with open-angle glaucoma. Arch Ophthalmol. 2012 Dec;130(12):1579-88.

Tash BR, Bewley MC, Russo M, Keil JM, Griffin KA, Sundstrom JM, Antonetti DA, Tian F, Flanagan JM. The occludin and ZO-1 complex, defined by small angle X-ray scattering and NMR, has implications for modulating tight junction permeability. Proc Natl Acad Sci U S A. 2012 Jul;109(27):10855-60. Taylor S, Chen J, Luo J, Hitchcock PF. Light-induced photoreceptor degeneration in the retina of the zebrafish. Methods Mol Biol. 2012;884:247-54. Thompson DA., Klionsky DJ. Autophagy and gene therapy combine in the treatment of liver disease. Autophagy. 2013 Apr 16;9(7). Titchenell PM, Antonetti DA. Using the past to inform the future: Anti-VEGF therapy as a road map to develop novel therapies for diabetic retinopathy. Diabetes. 2013 Jun;62(6):1808-15.

university of michigan kellogg eye center

Titchenell PM, Hollis Showalter HD, Pons JF, Barber AJ, Jin Y, Antonetti DA. Synthesis and structure-activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors. Bioorg Med Chem Lett. 2013 May;23(10):3034-8. Titchenell PM, Lin CM, Keil JM, Sundstrom JM, Smith CD, Antonetti DA. Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced bloodretinal barrier dysfunction. Biochem J. 2012 Sep;446(3):455-67. Trobe JD. The scholarly contributions of Daniel M. Jacobson, MD. J Neuroophthalmol. 2012 Dec;32(4):372-8. Ulmer M, Li J, Yaspan BL, Ozel AB, Richards JE, Moroi SE...Lichter PR, et al. Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia. Invest Ophthalmol Vis Sci. 2012 Jul;53(8):4468-74. Vanderbeek BL, Zacks DN, Talwar N, Nan B, Stein JD. Role of statins in the development and progression of age-related macular degeneration. Retina. 2013 Feb;33(2):414-22. Varma R, Bressler NM, Suner I, Lee PP, Dolan CM, Ward J, Colman S, Rubio RG. Improved vision-related function after ranibizumab for macular edema after retinal vein occlusion: Results from the BRAVO and CRUISE trials. Ophthalmology. 2012 Oct;119(10):2108-18. Verdier DD, Sugar A, Baratz K, Beck R, Dontchev M, Dunn S, Gal RL, Holland EJ, Kollman C, Lass JH, Mannis MJ, Penta J. Corneal thickness as a predictor of corneal transplant outcome. Cornea. 2013 Jun;32(6):729-36.

Faculty publications July 1, 2012 â&#x20AC;&#x201D; June 30, 2013

Verhoeven VJ, Hysi PG, Wojciechowski R, Fan Q, Guggenheim JA, Hohn R, MacGregor S, et al. Genome-wide metaanalyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nat Genet 2013 Mar;45(3):314-8. [Comer GM, Elner SG, Gardner TW, Hackel R, Mian SI, Soong HK, Sugar A - Collaborators] Wang I, Khan NW, Branham KE, Wissinger B, Kohl S, Heckenlively JR. Establishing baseline rod electroretinogram values in achromatopsia and cone dystrophy. Doc Ophthalmol Epub 2012 Aug 19. Weizer JS, Musch DC, Niziol LM, Khan NW. Multifocal visual evoked potentials for early glaucoma detection. Ophthalmic Surg Lasers Imaging. 2012 Jul;43(4):33540. West SK, Lee PP. Vision surveillance in the United States: Has the time come? Am J Ophthalmol. 2012 Dec;154(6 suppl):S1-S2. Wiggs JL, Hauser MA, Abdrabou W, Allingham RR, Budenz DL, Delbono E, Friedman DS, Kang JH, Gaasterland D, Gaasterland T, Lee RK, Lichter PR, Loomis S, Liu Y, McCarty C, Medeiros FA, Moroi SE, Olson LM, Realini A, Richards JE, Rozsa FW, Schuman JS, Singh K, Stein JD, Vollrath D, Weinreb RN, Wollstein G, Yaspan BL, Yoneyama S, Zack D, Zhang K, Pericak-Vance M, Pasquale LR, Haines JL. The NEIGHBOR Consortium Primary Open-Angle Glaucoma Genomewide Association Study: Rationale, study design, and clinical variables. J Glaucoma 2013 Sep;22(7):517-25. Epub 2012 July 26.

Wilkinson JE, Burmeister L, Brooks SV, Chan CC, Friedline S, Harrison DE, Hejtmancik JF, Nadon N, Strong R, Wood LK, Woodward MA, Miller RA. Rapamycin slows aging in mice. Aging Cell. 2012 Aug;11(4):675-82. Wong KY. A retinal ganglion cell that can signal irradiance continuously for 10 hours. J Neurosci 2012 Aug;32(33):11478-85. Woodward MA, Raoof-Daneshvar D, Mian SI, Shtein RM. Relationship of visual acuity and lamellar thickness in descemet stripping automated endothelial keratoplasty. Cornea. 2013 May;32(5):e69-73.

Zhang XJ, Liang YB, Liu YP, Jhanji V, Musch DC, Peng Y, Zheng CR, Zhang HX, Chen P, Tang X, Lam DS. Implementation of a free cataract surgery program in rural China: A community-based randomized interventional study. Ophthalmology. 2013 Feb;120(2):260-5. Zhang L, Weizer JS. Sequential glaucoma drainage devices for high intraocular pressure. Glaucoma Today. 2012 Nov-Dec. Zhang W, Zhang X, Wang H, Sharma AK, Hughes BA. Characterization of the R162W Kir7.1 mutation associated with snowflake vitreoretinopathy. Am J Physiol Cell Physiol. 2013 Mar;304(5):C440-9.

Woodward MA, Ross KW, Requard JJ, Sugar A, Shtein RM. Impact of surgeon acceptance parameters on cost and availability of corneal donor tissue for transplantation. Cornea. 2013 Jun;32(6):737-40. Yue H, Qian J, Elner VM, Guo J, Yuan YF, Zhang R, Ge Q. Treatment of orbital vascular malformations with intralesional injection of pingyangmycin. Br J Ophthalmol. 2013 Jun;97(6):739-45. Zahid S, Jayasundera KT, Rhoades W, Branham KE, Khan NW, Niziol LM, Musch DC, Heckenlively JR. Clinical phenotypes and prognostic full-field electroretinographic findings in Stargardt disease. Am J Ophthalmol. 2013 Mar;155(3):46573. Zahid S, Musch DC, Niziol LM, Lichter PR. Risk of endophthalmitis and other long-term complications of trabeculectomy in the Collaborative Initial Glaucoma Treatment Study (CIGTS). Am J Ophthalmol. 2013 Apr;155(4):674-80.

Innovation in vision

External grants and Funding July 1, 2012 â&#x20AC;&#x201D; June 30, 2013

Facult y Name

S ource

P roject Title

S. Abcouwer, Ph.D. NIH R01-EY020582-05 Regulation of Retinal Cell Death in Diabetes; Co-PI NIH R01-EY007739 Bone Marrow Neuropathy Drives Diabetic Retinopathy, Subcontract with University of Florida; PI: Maria Bartolomeo Grant, M.D. JDRF JDRF Center for Mechanisms and Intervention of Diabetic Retinopathy; Project 2 Co-PI JDRF Testing the Role of A3AR in Diabetic Retinopathy Pathologies D. Antonetti, Ph.D. NIH R01-EY-012021-16 Mechanisms of Retinal Vascular Permeability in Diabetes NIH R01-EY-021165 The Retinal Microenvironment in Diabetic Retinopathy Subcontract with Northwestern University, PI: Robert Linsenmeier, Ph.D. NIH R01-GM094526 Structural Studies of Tight Junction Proteins, Subcontract with Pennsylvania State University, PI: John M. Flanagan, Ph.D. JDRF Targeting aPKC as a Therapy for Diabetic Retinopathy JDRF JDRF Center for Mechanisms and Intervention of Diabetic Retinopathy; Project 2 Co-PI JDRF PolyChromatic Angiography for Grading Retinal Vascular Leakage RPB Jules and Doris Stein RPB Professorship B. Bohnsack, M.D., Ph.D. NIH K08-EY022912-01 Regulation of Ocular Neural Crest and Its Implications in Congenital Eye Diseases RPB A Zebrafish Model for Congenital Eye Diseases G. Comer, M.D., M.S. LMRI/ Clinical Trial A Natural History Study of Macular Telangiectasia â&#x20AC;&#x201D; The MacTel Study JDRF Structural and Functional Relationships of the Retina in Diabetic Macular Edema M. Del Monte, M.D. Alcon Laboratories, Inc. A 3-month, Multi-Center, Double-Masked Safety and Efficacy Study of Travoprost Ophthalmic Solution, 0.004% Compared to Timolol (0.5% or 0.25%) in Pediatric Glaucoma Patients Alcon Laboratories, Inc. An Open-Label, Pharmacokinetic and Safety Study of Travoprost Ophthalmic Solution, 0.004% in Pediatric Glaucoma or Ocular Hypertension Patients H. Demirci, M.D. Midwest Eye-Banks Roles of Inflammation and Angiogenesis in Conjunctival Melanoma: Progression and Metastasis R. Douglas, M.D., Ph.D. NIH R01-EY211197-03 Role of CD40+ Fibrocytes in Thyroid-Associated Ophthalmopathy

university of michigan kellogg eye center

External grants and Funding July 1, 2012 â&#x20AC;&#x201D; June 30, 2013

Facult y Name

S ource

P roject Title

R. Douglas, M.D., Ph.D. River Vision LLC A Multicenter, Double-Masked, Placebo-Controlled, Efficacy and (cont.) Safety Study of RV001, an Insulin-like Growth Factor-1 Receptro (IGF-1R) Antagonist Antibody (fully human), Administered Every 3 Weeks (Q3W) by Intravenous (IV) Infusion in Patients Suffering from Active Thyroid Eye Disease (TED) RPB Lew R. Wasserman Merit Award S. Elner, M.D. NIH/Clinical Trial U01-EY014660-06 Multicenter Uveitis Steroid Treatment (MUST) Trial Coordinating Center: Johns Hopkins University Santen Pharmeceutical Intravitreal Injections of DE-109 for the Treatment of Active, Non-Infectious Uveitis P. Fort, Ph.D. NIH R01-EY020895-01 Progressive Impact of Diabetes on Retinal Neuroprotection by Îą-Crystallins Midwest Eye-Banks Characterization of Crystallin Proteins Expression in Human Retina: Effect of Diabetes Fight for Sight Detailed Analysis of Crystallins Cellular and Sub-cellular Upregulation during Diabetic Retinopathy P. Gage, Ph.D.

NIH

R01-EY014126-10

Pitx 2: Molecular Mechanisms in Eye Development and Disease

T. Gardner, M.D., M.S. NIH R01-EY020582-05 Regulation of Retinal Cell Death in Diabetes; Co-PI NIH DP3-DK094292-02 Metabolic Reprogramming in Diabetic Complications; Co-PI Subaccount with Frank C. Brosius, M.D., Department of Nephrology, University of Michigan NIH K12-EY022299-01A1 Michigan Vision Clinician-Scientist Development Program; Co-PI NIH/Clinical Trial U10-EY14231 Prompt Panretinal Photocoagulation (Protocol S), Coordinating Center: Jaeb NIH/Clinical Trial U10-EY01423 Genes in Diabetic Retinopathy, Coordinating Center: Jaeb American Diabetes Association Evaluation of Diabetic Retinal Sensory Neuropathy JDRF JDRF Center for Mechanisms and Intervention of Diabetic Retinopathy JDRF Evaluation of Retinal Sensory Neuropathy Midwest Eye-Banks A Diabetic Retinopathy Risk of Progression Calculator RPB Physician-Scientist Award J. Heckenlively, M.D. NIH R21-EY022172-02 Investigation of Autoimmune Anti-Retinal Antibodies in Diabetes FFB Center for the Study of Retinal Degenerative Diseases The Juliette Retinitis Pigmentosa (RP) Foundation X-Chromosome Inactivation Ratios and Variable Expressivity in Heterozygotic Female Carriers of RPGR Mutations Award for Abigail Fahim, M.D., Ph.D. NNRI NNSP-CL-0212- A Phase II Multiple Site, Randomized, Placebo-Controlled 0061-MICH-NER Trial of Oral Valproic Acid for Retinitis Pigmentosa P. Hitchcock, Ph.D.

NIH NIH NIH

R01-EY007060-23 Neuronal Development, Injury and Repair in Retina T32-EY013934-11 Vision Research Training Program F32-EY023129-01 NRSA Postdoctoral Fellowship for Scott Taylor, Ph.D.

Innovation in vision

External grants and Funding July 1, 2012 — June 30, 2013

Facult y Name

S ource

P roject Title

B. Hughes, Ph.D.

NIH NIH

P30-EY007003-26 R01-EY008850-22

Core Center for Vision Research (five core modules) Ion Conductances in the Retinal Pigment Epithelium

T. Jayasundera, M.D. Alliance for Vision Research Quantification of Macular Autofluorescence in Dry Age-Related Macular Degeneration Fight for Sight Quantification of Changes in Macular Autofluorescence in Dry Age-Related Macular Degeneration Midwest Eye-Banks Novel Quantification Methods for Fundus Flavoprotein Fluorescence and Lipofuscin Fluorescence to Detect Progression in Stargardt Disease A. Kahana, M.D., Ph.D. NIH R01-EY022633-01A1 A Zebrafish Model of Extraocular Muscle Regeneration Alliance for Vision Research Biological Signals Controlling Extraocular Muscle Regeneration Alliance for Vision Research Chemical Genomic Screen for Modifiers of Axenfeld-Rieger Syndrome: A Pilot Study to Identify Novel Therapeutics of Anterior Segment Dysgenesis Alliance for Vision Research Investigating the Role of Extracellular Matrix Factors and Collective Cell Migration in Extraocular Muscle Repair and Regeneration Using a Zebrafish Model Alliance for Vision Research Investigating the Roles of Retinoic Acid and Thyroid Hormone in the Pathogenesis of Thyroid Eye Disease Alliance for Vision Research Investigating the Roles of Twist1 and Twist2 in Extraocular Muscle Biology and Orbital Rhabdomyosarcoma Alliance for Vision Research Regulation of Extraocular Muscle Response to Injury by Autophagy and Extracellular Matrix Remodeling, Possible Targets for Therapy Alliance for Vision Research Thyroid-Related Eye Disease: A Preclinical Study Investigating the Role of Retinoid Receptors in Mediating Orbitopathy Midwest Eye-Banks Chemical Genomic Screen for Modifiers of Axenfeld-Rieger Syndrome RPB Career Development Award P. Lee, M.D., J.D.

NIH K12-EY022299-01A1 Michigan Vision Clinician-Scientist Development Program; Co-PI NIH Vision Health Initiative - IPA with CDC RPB Unrestricted Grant 2013 W. K. Kellogg Foundation Child Vision Care Fund

P. Lichter, M.D.

RPB

Unrestricted Grant 2012

S. Mian, M.D. Alliance for Vision Research Ocular Findings after Hematopoietic Stem Cell Transplantation Bausch & Lomb, Inc. Treatment of Ocular Graft-versus-Host Disease (GVHD) with Topical Loteprednol Etabonate 0.5% Midwest Eye-Banks Eye Bank Preparation of Donor Tissue for Descemet’s Membrane Endothelial Keratoplasty Midwest Eye-Banks Tissue Processing Techniques for Ultra-Thin Descemet’s Stripping Endothelial Keratoplasty, Award for Maria Woodward, M.D.

university of michigan kellogg eye center

External grants and Funding July 1, 2012 â&#x20AC;&#x201D; June 30, 2013

Facult y Name

S ource

P roject Title

S. Moroi, M.D., Ph.D. NIH R01-EY-022124-02 Aqueous Humor Dynamic Components that Determine Intraocular Pressure Variance D. Musch, Ph.D., M.P.H. NIH R21-EY-020912-02 Clinical and Quality of Life Insights on Glaucoma from Analyses of CIGTS Data NIH R34-EY022399-01A1Â Statins To Prevent Glaucoma Trial (STOP Glaucoma Trial) Planning Grant NIH R21-EY023452 Factors Predictive of Rapid Visual Field Loss in Early Glaucoma, Subcontract with Washington University, Co-PI: Feng Gao, M.D., Ph.D., Mae O. Gordon, Ph.D. RPB ` Lew R. Wasserman Award H. Pawar, Ph.D. Alliance for Vision Research Defining the Anatomical Mechanism of Canaloplasty Angle Surgery H. Petty, Ph.D. Alliance for Vision Research Evaluating the Toxicity of Novel Anti-Tumor Nanoparticles in Animals Alliance for Vision Research Mechanistic Studies of a New Light-Activated Nanoparticle for Managing Ocular Cancer Elsa U. Pardee Foundation Pilot Studies on the Anti-Tumor Capacity of Novel Catalytic Nanoparticles D. Puro, M.D., Ph.D. NIH R01-EY012507-14 Retinovascular Pathophysiology: Focus on Proliferative Retinopathy Alliance for Vision Research Retinopathy of Prematurity: A New Experimental Approach J. Richards, Ph.D.

NIH R01-EY011671-11 NIH R21 EY021000-02 RPB

Molecular Genetics of Primary Open-Angle Glaucoma Ocular Effects of Metformin Senior Scientific Investigator Award

R. Shtein, M.D., M.S. NIH K23-EY017885-04 Neovascularization Patterns in Corneal Graft Rejection NIH P60-DK020572-34 In Vivo Corneal Confocal Microscopy for Non-invasive Assessment of Diabetic Peripheral Neuropathy; Subaccount with Michigan Diabetes Research and Training Center, University of Michigan, Co-PI Alliance for Vision Research Trends in Utilization of Endothelial and Penetrating Keratoplasty for Treatment of Corneal Endothelial Disease T. Smith, M.D. NIH R01-DK063121-05 Immunoglobulin Activation of Fibroblasts NIH R01-EY008976-19 Regulation of Retroocular Connective Tissue NIH R01-EY011708-16 Functional Diversity of Orbital Fibroblasts RPB Physician-Scientist Award J. Stein, M.D., M.S. NIH K23-EY019511-04 Association between Cataract Surgery and Progression of Diabetic Retinopathy NIH R03-DE022654 Metabolic Syndrome and Periodontitis in Postmenopausal Women, Subcontract with State University of New York at Buffalo, PI: Michael J. LaMonte, Ph.D., M.P.H. Innovation in vision

External grants and Funding July 1, 2012 â&#x20AC;&#x201D; June 30, 2013

Facult y Name

S ource

P roject Title

J. Stein, M.D., M.S. NIH R01-AG041776 The Role of Vitamin D in Retinal Diseases in Aging, Subcontract (cont.) with State University of New York at Buffalo, PI: Amy E. Millen, Ph.D. Alliance for Vision Research A Diabetic Retinopathy Progression Risk Calculator American Glaucoma Society Mentoring for Advancement of Physician-Scientist Enabling Award Program Blue Cross Blue Shield of Michigan Longitudinal Rates of Postoperative Adverse Outcomes after Glaucoma Surgery among Medicare Beneficiaries 1994â&#x20AC;&#x201C;2005 Harvard Medical School Assessment of the Relation between Medications that Alter Innate Immunity and Glaucoma RPB Physician-Scientist Award A. Sugar, M.D.

NIH/Clinical Trial NIH/Clinical Trial

U10-EY012358 U10-EY020797-01

Cornea Donor Study, Coordinating Center: Jaeb Corneal Preservation Time Study, Coordinating Center: Jaeb

D. Thompson, Ph.D. FFB Center for the Study of Retinal Degenerative Diseases FFB Gene-Replacement Therapy for XLRP Due to RPGR Mutations - Continuation RDH12 Fund for Sight Gene-Replacement Therapy for RDH12 Mutations K. Wong, Ph.D. NIH R00-EY018863-05 Cross-Talk between Ganglion-Cell Photoreceptors and Other Neurons in the Retina Alliance for Vision Research Ameliorating the Condition of the Blind through Melanopsin Midwest Eye-Banks Functional Characterization of Developmental Changes in NMDA Receptor Subunit Compostion of Retinal Ganglion Cells RPB Career Development Award D. Zacks, M.D., Ph.D. NIH R01-EY020823-04 Autophagy and Control of Photoreceptor Apoptosis NIH R43-EY022512 Feasibility Study of ONL-101 for Photoreceptor Neuroprotection Prevention of Photoreceptor Cell Death with Intravitreal Fas-receptor Antagonist, Subcontract with ONL Therapeutics, PI: Jeffrey A. Jamison, Ph.D. Beckman Foundation Autophagy and Age-Related Macular Degeneration FFB Center for the Study of Retinal Degenerative Diseases RPB Sybil B. Harrington Special Scholar Award for Macular Degeneration

Source Abbreviations

FFB

JDRF ................. Juvenile Diabetes Research Foundation International

NIH ................... National Institutes of Health

NNRI ................ National Neurovision Research Institute

NSF ............. National Science Foundation

RPB ............. Research to Prevent Blindness

.................... Foundation

university of michigan kellogg eye center

Fighting Blindness

Meet Kellogg’s New Faculty César A. Briceño, M.D., assistant professor, has joined the faculty of the Eye Plastic, Orbital and Facial Cosmetic Surgery section. Dr. Briceño received his medical degree from Johns Hopkins University and then completed his residency at the Doheny Eye Institute at the University of Southern California. In 2013, Dr. Briceño completed a fellowship in oculoplastics at Kellogg. He sees patients in our Ann Arbor and Canton offices. Lindsey B. De Lott, M.D., clinical lecturer, has joined the faculty of the NeuroOphthalmology section. She earned her medical degree from Ohio State University and completed her residency in neurology at the University of Michigan. In 2013, Dr. De Lott completed a two-year fellowship in neuro-ophthalmology at Kellogg. Dr. De Lott sees patients in Kellogg’s Ann Arbor office and in the Neuro-Ophthalmology suite at U-M Hospital. Read about Dr. De Lott’s research interests on p.5 Blake V. Fausett, M.D., Ph.D., clinical lecturer, has joined the faculty of the Comprehensive Ophthalmology and Cataract Surgery section and sees patients in Kellogg’s Ann Arbor office. Dr. Fausett earned his medical degree and a Ph.D. in biochemistry from the University of Michigan and completed his residency at Kellogg. In addition to seeing patients, Dr. Fausett serves as the residency program’s first Graduate Chief Resident. Jonathan B. Greene, M.D., assistant professor, has joined the faculty of the Comprehensive Ophthalmology and Cornea sections. Dr. Greene earned his medical degree from the University of Michigan and completed his residency at the University of California, San Francisco. In 2013, Dr. Greene completed a fellowship in cornea and refractive surgery at Kellogg. He sees patients in Ann Arbor.

Vanitha I. Jeyaraj, M.D., clinical instructor, has joined the faculty of the Comprehensive Ophthalmology and Cataract Surgery section and sees patients in Kellogg’s Milford office. Dr. Jeyaraj earned her medical degree from the University of Chicago in 2009 and completed her residency at the Baylor College of Medicine in 2013. Paula Anne Newman-Casey, M.D., assistant professor, has joined the faculty of the Glaucoma, Cataract, and Anterior Segment Disease section and sees patients in Kellogg’s Canton office. Dr. NewmanCasey earned her medical degree at the University of Michigan and went on to complete her residency and a fellowship in glaucoma at Kellogg. Read about Dr. Newman-Casey’s research interests on p.4 Rajesh C. Rao, M.D., assistant professor, has joined the faculty of the Retina and Uveitis section and sees patients in Kellogg’s Ann Arbor office. Dr. Rao earned his medical degree at Yale University and completed his residency at the Massachusetts Eye and Ear Infirmary. He completed a fellowship in vitreoretinal surgery at Washington University. Read about Dr. Rao’s research interests on p.19 Anjali Shah, M.D., clinical instructor, has joined the faculty of the Retina and Uveitis section and sees patients in Kellogg’s Ann Arbor and Brighton offices. Dr. Shah earned her medical degree from the University of Michigan and completed her residency at the Baylor College of Medicine. She then completed a medical retina fellowship at the Tufts/New England Eye Center. Linda Zhang, M.D., clinical lecturer, has joined the faculty of the Glaucoma, Cataract, and Anterior Segment Disease section and sees patients in Kellogg’s Ann Arbor and Brighton offices. Dr. Zhang earned her medical degree at the University of Michigan and then went on to complete her residency and a fellowship in glaucoma at Kellogg.

To request an appointment with our new clinicians, please call 734.763.8122. Referring physicians can reach these clinicians through M-LINE at 800.962.3555. Innovation in vision

Faculty of the Department of Ophthalmology and Visual Sciences – Fall 2013

Leadership Paul P. Lee, M.D., J.D. Chair Alan Sugar, M.D. Vice Chair Michael W. Smith-Wheelock, M.D. Associate Chair for Clinical Affairs Shahzad I. Mian, M.D. Associate Chair for Education Thomas W. Gardner, M.D., M.S. Associate Chair for Research Section leaders Jill E. Bixler, M.D. Comprehensive Ophthalmology and Cataract Surgery Donna M. Wicker, O.D., FAAO Contact Lens, Low Vision and Visual Rehabilitation H. Kaz Soong, M.D. Cornea and External Disease, Cataract and Refractive Surgery Christine C. Nelson, M.D., FACS Eye Plastic, Orbital and Facial Cosmetic Surgery Sayoko E. Moroi, M.D., Ph.D. Glaucoma, Cataract and Anterior Segment Disease Jonathan D. Trobe, M.D. Neuro-Ophthalmology Monte A. Del Monte, M.D. Pediatric Ophthalmology and Adult Strabismus Mark W. Johnson, M.D. Retina and Uveitis Adrienne L. West, M.D. At large Comprehensive Ophthalmology and Cataract Surgery Faculty Steven F. Abcouwer, Ph.D. Vision Research James L. Adams, M.D. Eye Plastic, Orbital and Facial Cosmetic Surgery David A. Antonetti, Ph.D. Vision Research Steven M. Archer, M.D. Pediatric Ophthalmology and Adult Strabismus Terry J. Bergstrom, M.D. Comprehensive Ophthalmology and Cataract Surgery Donald S. Beser, M.D., FACS Comprehensive Ophthalmology and Cataract Surgery Cagri G. Besirli, M.D., Ph.D. Retina and Uveitis

Brenda L. Bohnsack, M.D., Ph.D. Pediatric Ophthalmology and Adult Strabismus Kari E. Branham, M.S., C.G.C. Genetic Counseling and Vision Research César A. Briceño, M.D. Eye Plastic, Orbital and Facial Cosmetic Surgery Grant M. Comer, M.D., M.S. Retina and Uveitis Theresa M. Cooney, M.D. Cornea and External Disease, Cataract and Refractive Surgery Wayne T. Cornblath, M.D. Neuro-Ophthalmology Sherry H. Day, O.D., FAAO Contact Lens, Low Vision and Visual Rehabilitation Karen S. DeLoss, O.D., FAAO Contact Lens, Low Vision and Visual Rehabilitation Lindsey B. De Lott, M.D. Neuro-Ophthalmology

Hilary M. Grabe, M.D. Neuro-Ophthalmology

Arivalagan Muthusamy, Ph.D. Vision Research

Daniel G. Green, Ph.D. Vision Research

Paula Anne Newman-Casey, M.D., M.S. Glaucoma, Cataract and Anterior Segment Disease

Jonathan B. Greene, M.D. Cornea and External Disease, Cataract and Refractive Surgery Paul J. Grenier, O.D. Contact Lens, Low Vision and Visual Rehabilitation John R. Heckenlively, M.D. Retina and Uveitis Peter F. Hitchcock, Ph.D. Vision Research Christopher T. Hood, M.D. Cornea and External Disease, Cataract and Refractive Surgery Bret A. Hughes, Ph.D. Vision Research Ida L. Iacobucci, C.O. Pediatric Ophthalmology and Adult Strabismus Diane M. Jacobi, O.D. Contact Lens, Low Vision and Visual Rehabilitation K. Thiran Jayasundera, M.D., FACS, FRCSC, FRANZCO Retina and Uveitis Vanitha I. Jeyaraj, M.D. Comprehensive Ophthalmology and Cataract Surgery

Hakan Demirci, M.D. Orbital and Ocular Oncology

Denise A. John, M.D., FRCSC Glaucoma, Cataract and Anterior Segment Disease

Courtney A. Dewey, O.D. Pediatric Ophthalmology and Adult Strabismus

Alon Kahana, M.D., Ph.D. Eye Plastic, Orbital and Facial Cosmetic Surgery

Raymond S. Douglas, M.D., Ph.D. Eye Plastic, Orbital and Facial Cosmetic Surgery

Ariane D. Kaplan, M.D. Comprehensive Ophthalmology and Cataract Surgery

Elizabeth Du, M.D. Comprehensive Ophthalmology and Cataract Surgery

Harjeet Kaur, M.D., FRCS(I) Comprehensive Ophthalmology and Cataract Surgery

Susan G. Elner, M.D. Retina and Uveitis

Naheed W. Khan, Ph.D. Vision Research

Victor M. Elner, M.D., Ph.D. Eye Plastic, Orbital and Facial Cosmetic Surgery

Jennifer A. Kozak, M.D. Pediatric Ophthalmology and Adult Strabismus

Blake V. Fausett, M.D., Ph.D. Comprehensive Ophthalmology and Cataract Surgery

Amy L. Lagina, O.D. Contact Lens, Low Vision and Visual Rehabilitation

Jerome I. Finkelstein, M.D., FACS Comprehensive Ophthalmology and Cataract Surgery

Helios T. Leung, O.D., Ph.D., FAAO Contact Lens, Low Vision and Visual Rehabilitation

Patrice E. Fort, Ph.D. Vision Research

Paul R. Lichter, M.D., FACS Glaucoma, Cataract and Anterior Segment Disease

Carlton J. Foster, O.D. Pediatric Ophthalmology and Adult Strabismus

Cheng-mao Lin, Ph.D. Vision Research

Bruce A. Furr, C.O., Ph.D. Pediatric Ophthalmology and Adult Strabismus

Michael J. Lipson, O.D., FAAO Contact Lens, Low Vision and Visual Rehabilitation

Philip J. Gage, Ph.D. Vision Research

Xuwen Liu, M.D., Ph.D. Vision Research

Christopher Gappy, M.D. Pediatric Ophthalmology and Adult Strabismus

David C. Musch, Ph.D., M.P.H. Vision Research

Gale A. Oren, M.I.L.S. Library Hemant Pawar, Ph.D. Vision Research Howard R. Petty, Ph.D. Vision Research Donald G. Puro, M.D., Ph.D. Comprehensive Ophthalmology and Cataract Surgery Rajesh C. Rao, M.D. Retina and Uveitis Julia E. Richards, Ph.D. Vision Research Frank W. Rozsa, Ph.D. Vision Research Gary S. Sandall, M.D., FACS Pediatric Ophthalmology and Adult Strabismus Anjali Shah, M.D. Retina and Uveitis Roni M. Shtein, M.D., M.S. Cornea and External Disease, Cataract and Refractive Surgery Terry J. Smith, M.D. Eye Plastic, Orbital and Facial Cosmetic Surgery Endocrinology Joshua D. Stein, M.D., M.S. Glaucoma, Cataract and Anterior Segment Disease Bradley W. Taylor, O.D., M.P.H. Contact Lens, Low Vision and Visual Rehabilitation Debra A. Thompson, Ph.D. Vision Research Susan S. Thoms, M.D. Comprehensive Ophthalmology and Cataract Surgery Joshua P. Vrabec, M.D. Comprehensive Ophthalmology and Cataract Surgery Jennifer S. Weizer, M.D. Glaucoma, Cataract and Anterior Segment Disease Kwoon Y. Wong, Ph.D. Vision Research Maria A. Woodward, M.D. Cornea and External Disease, Cataract and Refractive Surgery Rebecca A. Wu, M.D. Comprehensive Ophthalmology and Cataract Surgery Dongli Yang, M.D., Ph.D. Vision Research David N. Zacks, M.D., Ph.D. Retina and Uveitis Linda Zhang, M.D. Glaucoma, Cataract and Anterior Segment Disease Sergey N. Zolov, Ph.D. Vision Research

Educating the next generation of ophthalmologists and vision scientists Our residents, clinical fellows, and research fellows are an important part of the Kellogg community. At Kellogg we are committed to bringing new technologies and approaches to education to help our graduates meet the challenges of changing health care and research environments.

Graduate Chief Resident Blake V. Fausett, M.D., Ph.D. Lecturer, Comprehensive Ophthalmology and Cataract Surgery M.D. University of Michigan Ph.D. University of Michigan 1st Year Residents David DeMill, M.D. M.D. University of Utah Neil Farbman, J.D., M.D. J.D. Harvard University M.D. University of Pennsylvania Michelle Kron-Gray, M.D., Ph.D. M.D. University of Michigan Ph.D. Neuroscience, University of Michigan

Matthew Manry, M.D. M.D. University of South Florida Monica Michelotti, M.D. M.D. University of Michigan Melisa Nika, M.D. M.D. University of Michigan Andrew Stacey, M.S., M.D. M.S. Brigham Young University M.D. Ohio State University 3rd Year Residents Nicholas D. Chinskey, M.D. M.D. University of Michigan Abigail T. Fahim, M.D., Ph.D. M.D. Baylor University Ph.D. University of Michigan

Stephen Smith, M.D. M.D. Mayo Medical School

Ryan J. Fante, M.D. M.D. University of Colorado Denver

Maxwell Stem, M.D. M.D. Pennsylvania State University

Denise S. Kim, M.D. M.D. University of Michigan

Kevin Tozer, M.D. M.D. University of Southern California

Crandall E. Peeler, M.D. M.D. Dartmouth College

Grace Wang, M.D., Ph.D. M.D. Johns Hopkins University Ph.D. Johns Hopkins University 2nd Year Residents Courtney Kauh, M.D., M.S. M.S. Ohio State University M.D. University of Toledo Mehnaz Khan, M.D., M.S. M.S. Johns Hopkins University M.D. Vanderbilt University Lee Kiang, M.D., Ph.D. M.D. Weill Cornell Medical College Ph.D. The Rockefeller University

Patricia A. Ple-plakon, M.D. M.D. University of Michigan Ira H. Schachar, M.D., M.Sc. M.D. Washington University M.Sc. Oxford University Clinical Fellows Alexandra Apkarian, M.D. Pediatric Ophthalmology and Adult Strabismus M.D. University of Michigan Residency University of Michigan Surbhi Bansal, M.D. Glaucoma, Cataract and Anterior Segment Disease M.D. University at Buffalo Residency University at Buffalo

Dane Breker, M.D. Neuro-Ophthalmology M.D. University of North Dakota Residency University of Michigan Michael Bullard, M.D. Pediatric Ophthalmology and Adult Strabismus M.D. University of Iowa Residency University of Michigan Steven Cohen, M.D. Vitreo-Retinal Surgical M.D. University of Missouri Kansas City Residency University of Texas Health Science Center Angela Elam, M.D. Glaucoma, Cataract and Anterior Segment Disease M.D. Duke University Residency University of Pittsburgh Joshua Grant, M.D. Medical Retinal M.D. Wayne State University Residency University of South Florida Chirag Gupta, M.D. Cornea and External Disease, Cataract and Refractive Surgery M.D. University of Michigan Residency William Beaumont Hospital Lauren Harris, M.D. Cornea and External Disease, Cataract and Refractive Surgery M.D. University of Tennessee Residency University of Tennessee Nieraj Jain, M.D. Vitreo-Retinal Surgical M.D. Duke University Residency Duke University Allison N. McCoy, M.D., Ph.D. Eye Plastic, Orbital and Facial Cosmetic Surgery M.D., Ph.D. Duke University Residency Wilmer Eye Institute Dolly Padovani-Claudio, M.D., Ph.D. Pediatric Ophthalmology and Adult Strabismus M.D., Ph.D. Case Western Reserve University Residency University of Michigan Fatemeh Rajaii, M.D., Ph.D. Eye Plastic, Orbital and Facial Cosmetic Surgery M.D., Ph.D. Johns Hopkins University Residency Wilmer Eye Institute

Rashmi Verma, MS Ophth. Neuro-Ophthalmology MS Ophth. Regional Institute of Ophthalmology, Gandhi Medical College & Associated Hamidia Hospital, Barkatullah University, Bhopal (MP), India Fellowship Pediatric Ophthalmology, Akron Childrenâ&#x20AC;&#x2122;s Hospital Research Fellows Esther Gramage Caro, Ph.D. Ph.D. Universidad San Pablo-CEU, Madrid, Spain Lisheng Chen, Ph.D. Ph.D. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China Travis Dâ&#x20AC;&#x2122;Cruz, Ph.D. Ph.D. Pennsylvania State University Jennifer Dulle, Ph.D. Ph.D. Washington University Edith Arnold Hernandez, Ph.D. Ph.D. Universidad Autonoma de San Luis Potosi, Mexico Ryohsuke Kohmoto, M.D. M.D. Osaka Medical College, Osaka, Japan Jason M. Miller, M.D., Ph.D. M.D. University of California, San Francisco Ph.D. University of California, San Francisco Nupur Raychaudhuri, Ph.D. Ph.D. Bose Institute, Calcutta, India Shameka J. Shelby, Ph.D. Ph.D. University of Michigan Benjamin K. Stafford, Ph.D. Ph.D. University of California, Santa Cruz Scott M. Taylor, Ph.D. Ph.D. Florida Institute of Technology Alfonso Saera Vila, Ph.D. Ph.D. University of Valencia, Valencia, Spain Xiwu Zhao, Ph.D. Ph.D. Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

W.K. Kellogg Eye Center Faculty, Fellows, and Residents 2013

All of us at the Kellogg Eye Center are committed to improving lives through curing, preventing, and treating eye disease. Faculty of the Department of Ophthalmology and Visual Sciences 1st Row: Thomas W. Gardner, M.D., M.S., Alan Sugar, M.D., Paul P. Lee, M.D., J.D., Shahzad I. Mian, M.D., Michael W. Smith-Wheelock, M.D. 2nd Row: Naheed W. Khan, Ph.D., Jennifer A. Kozak, M.D., Jonathan D. Trobe, M.D., Sayoko E. Moroi, M.D., Ph.D., Donna M. Wicker, O.D., H. Kaz Soong, M.D., Adrienne L. West, M.D., Christine C. Nelson, M.D., Monte A. Del Monte, M.D., Mark W. Johnson, M.D., Jennifer S. Weizer, M.D., Denise S. Kim, M.D., Sherry H. Day, O.D., Allison N. McCoy, M.D., Ph.D., Kristen Harris Nwanyanwu, M.D., M.B.A 3rd Row: Patricia A. Ple-plakon, M.D., Jeffrey M. Sundstrom, M.D., Ph.D., David C. Musch, Ph.D., M.P.H., Paul R. Lichter, M.D., Hakan Demirci, M.D., Frank W. Rozsa, Ph.D., Rebecca A. Wu, M.D., Kari Branham, M.S., C.G.C., Partho Satish Kalyani, M.D., Susan S. Thoms, M.D., Terry J. Bergstrom, M.D., Bret A. Hughes, Ph.D., Nieraj Jain, M.D., Joshua D. Stein, M.D., M.S., Courtney A. Dewey, O.D., Alon Kahana, M.D., Ph.D. 4th Row: Courtney Kauh, M.S., M.D., S. Asha Balakrishnam, M.D., Ariane D. Kaplan, M.D., Shivani Gupta, M.D., M.P.H., Paula Anne Newman-Casey, M.D., M.S., Duna Raoof-Daneshvar, M.D., Joshua P. Vrabec, M.D., Brenda L. Bohnsack, M.D., Ph.D., Christopher T. Hood, M.D., Matthew Manry, M.D., César A. Briceño, M.D., Gale A. Oren, M.I.L.S., Denise A. John, M.D., Gary S. Sandall, M.D., Lindsey B. De Lott, M.D., Hilary M. Grabe, M.D., Theresa M. Cooney, M.D., Elizabeth Du, M.D., David A. Antonetti, Ph.D., Abigail T. Fahim, M.D., Ph.D., Lee Kiang, M.D., Ph.D. 5th Row: Blake V. Fausett, M.D., Ph.D., Michael Bullard, M.D., Alexandra O. Apkarian, M.D., Monica Michelotti, M.D., Paul J. Grenier, O.D., Kwoon Y. Wong, Ph.D., Steven F. Abcouwer, Ph.D., Peter F. Hitchcock, Ph.D., Helios T. Leung, Ph.D., O.D., Carlton J. Foster, O.D., Amy L. Lagina, O.D., Wayne T. Cornblath, M.D., Nicholas D. Chinskey, M.D., Travis C. Rumery, M.D., Bruce A. Furr, C.O., Ph.D., Donald G. Puro, M.D., Ph.D., Cheng-mao Lin, Ph.D., Linda Zhang, M.D., Shreya S. Prabhu, M.D. 6th Row: Ira H. Schachar, M.D., Stephanie Chu, M.D., Andrew Stacey, M.S., M.D., David N. Zacks, M.D., Ph.D., Ryan J. Fante, M.D., Crandall E. Peeler, M.D., Nadeem H. Fatteh, M.D., Philip J. Gage, Ph.D., Jonathan B. Greene, M.D., Christopher Gappy, M.D., Steven M. Archer, M.D., Arivalagan Muthusamy, Ph.D., Xuwen Liu, M.D., Ph.D., Karen S. DeLoss, O.D., Cagri G. Besirli, M.D., Ph.D., K. Thiran Jayasundera, M.D., Jerome I. Finkelstein, M.D., Bradley W. Taylor, O.D., M.P.H., Debra A. Thompson, Ph.D., John R. Heckenlively, M.D., Hemant S. Pawar, Ph.D.

Our guiding principles are teamwork, caring, innovation, and integrity. In 2013, the W.K. Kellogg Eye Center was again named one of the top ophthalmology programs in the country by U.S. News and World Report.

Executive Officers of the University of Michigan Health System Ora Hirsch Pescovitz, M.D. Executive Vice President for Medical Affairs Douglas L. Strong, M.B.A. Chief Executive Officer, U-M Hospitals and Health Centers James O. Woolliscroft, M.D. Dean, U-M Medical School The Regents of the University of Michigan Mark J. Bernstein, Julia Donovan Darlow, Laurence B. Deitch, Shauna Ryder Diggs, Denise Ilitch, Andrea Fischer Newman, Andrew C. Richner, Katherine E. White, Mary Sue Coleman (ex officio) Editor: Betsy Nisbet Writers: Aimee Bergquist, Barbara Sefton Editorial Assistant: Lisa Burkhart Design and Art Direction: David Murrel Photographers: Eric Bronson, Roger Hart, Scott Soderberg, Austin Thomason, Martin Vloet, Michigan Photography; Lin Goings, U-M Department of Ophthalmology and Visual Sciences

For patient questions, please call 734.763.8122 For additional copies, please contact us: University of Michigan Department of Ophthalmology and Visual Sciences W.K. Kellogg Eye Center 1000 Wall Street Ann Arbor, Michigan 48105 734.763.4660 • www.kellogg.umich.edu

How to Contact a Kellogg Doctor

Call the Kellogg Eye Center To make an appointment, you can call the clinic or our main line: 734.763.8122 Comprehensive Ophthalmology and Cataract Surgery 734.764.4190 Contact Lens 734.764.5106

Call One of Our Community Clinics for Comprehensive and Specialty Care Briarwood – 734.647.9000 Brighton – 810.227.2357 Canton – 734.844.5400 Chelsea – 734.475.1321

Cornea, External Disease, and Cataract Surgery 734.764.5106 Eye Plastic, Orbital and Facial Cosmetic Surgery 734.764.5106 Glaucoma and Cataract Surgery 734.763.5874 LASIK and other Refractive Surgery 734.615.6914 Low Vision and Visual Rehabilitation 734.764.5106 Neuro-Ophthalmology 734.764.5106 Ocular Oncology 734.763.5874

Livonia – 734.432.7811 Milford – 248.684.7337 Ypsilanti – 734.615.0788

Find More on the Web Physician Bios: www.kellogg.umich.edu/about/faculty_bios.html Kellogg Research: www.kellogg.umich.edu/research Kellogg Clinics: www.kellogg.umich.edu/patientcare/ specialties.html

For Our Referring Physicians Make a referral or speak with a physician

Pediatric Ophthalmology and Adult Strabismus 734.764.7558

24 hours a day via M-LINE at 800.962.3555

Retina and Uveitis 734.763.5874

Jennifer Ziehm-Scott, Kellogg Physician Liaison, at

Thyroid Eye Disease Center 734.764.5106 Learn more about Patient Services at Kellogg www.kellogg.umich. edu/patientcare

If you have questions or concerns, please contact 734.615.8200

TEAMWORK INTEGRITY INNOVATION CARING