Liver transplantation is surgery to remove a diseased liver and replace it with a healthy liver from an organ donor. A liver transplant is necessary when disease makes the liver stop working. The most common reason for liver transplantation in adults is cirrhosis, a disease in which healthy liver cells are killed and replaced with scar tissue. The most common reason for transplantation in children is biliary atresia, a disease in which the ducts that carry bile out of the liver are missing or damaged.