Get Pain Relieving Medication Right Away The most suffocating thing is to bear pain. Extreme pain impairs concentration at work and causes sleep discomfort. Tramadol 50mg is the most effective pain reliever, acting in 30 minutes and lasting 3 hours. Tramadol 50 mg is an extended-release tramadol medication used to treat chronic pain. It is a synthetic opioid that inhibits nerve-to-brain communication. It is a powerful pain reliever that is used to treat moderate to severe pain in the body. Tramadol is named after the opiate Ultram, which is used to treat pain. His medication is taken orally and produces a formulation that begins working within 30 minutes.