The architecture of an antibody-drug conjugate (ADC) is a delicate balance of three components: the antibody, the payload, and the linker. While much attention is paid to the potency of the toxin, the length of the PEG linker often denoted by the number of repeat ethylene glycol units, is a primary determinant of how the drug behaves in the human body. Short linkers may provide higher stability but can hinder the antibody’s ability to bind to its target due to steric interference. Conversely, excessively long linkers can increase the flexibility of the conjugate to a point where it becomes vulnerable to premature metabolic clearance.
https://tide-chem.com/peg-linkers-and-applications/what-are-peg-linkers.html
