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Urological Tumours
Renal Pelvis and Ureter (ICD‐O‐3 C65, C66) Rules for Classification The classification applies to carcinomas. Papilloma is excluded. There should be histological or cytological confirmation of the disease. The following are the procedures for assessing T, N, and M categories: T categories Physical examination, imaging, and endoscopy N categories Physical examination and imaging M categories Physical examination and imaging
Anatomical Sites 1. Renal pelvis (C65) 2. Ureter (C66)
Regional Lymph Nodes The regional lymph nodes are the hilar, abdominal para‐aortic, and paracaval nodes and, for ureter, intrapelvic nodes. Laterality does not affect the N classification.
TNM Clinical Classification T – Primary Tumour TX T0 Ta Tis
Primary tumour cannot be assessed No evidence of primary tumour Non‐invasive papillary carcinoma Carcinoma in situ
T1 Tumour invades subepithelial connective tissue T2 Tumour invades muscularis T3 (Renal pelvis) Tumour invades beyond muscularis into peripelvic fat or renal parenchyma (Ureter) Tumour invades beyond muscularis into periureteric fat T4 Tumour invades adjacent organs or through the kidney into perinephric fat
Renal Pelvis and Ureter
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NX Regional lymph nodes cannot be assessed N0 No regional lymph node metastasis N1 Metastasis in a single lymph node 2 cm or less in greatest dimension N2 Metastasis in a single lymph node more than 2 cm, or multiple lymph nodes
M – Distant Metastasis M0 No distant metastasis M1 Distant metastasis
pTNM Pathological Classification The pT and pN categories correspond to the T and N categories. For pM see page 8.
Stage Stage 0a Stage 0is Stage I Stage II Stage III Stage IV
Ta Tis T1 T2 T3 T4 Any T Any T
N0 N0 N0 N0 N0 N0 N1, N2 Any N
M0 M0 M0 M0 M0 M0 M0 M1
Urological
N – Regional Lymph Nodes