the gem genomics epidemics microbes Sep/Oct 2025

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the gem

Cape HealthTech

A brand new platform, igniting collaboration for health innovation

Innovating for Impact

CERI and Google DeepMind at the G20 Digital Innovation Challenge

Cultivating Scientists

Meet some of our IPD African STARS fellows in Senegal, all part of shaping a generation of leaders

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Cape HealthTech Connect

CERI, the LaunchLab, Stellenbosch Network and Innovus at Stellenbosch University welcomed a vibrant gathering of innovators at the inaugural Cape HealthTech Connect event at BMRI, Tygerberg campus, on September 18.

G20 Digital Innovation Challenge

The G20 Digital Innovation Alliance (G20-DIA) promote innovative digital solutions from startups in G20 countries, focusing on collaboration with industry leaders to enhance socio-economic development in Africa.

IPD African STARS Fellows

At the Center for Africa’s Resilience to Epidemics (CARE) at the Institut Pasteur de Dakar, in Senegal, the African STARS Fellowship is doing more than training scientists – it’s shaping a generation of leaders.

the gem: Centre for Epidemic Response and Innovation (CERI) & South African Centre for Epidemiology and Modelling Analysis (SACEMA), Stellenbosch University & KwaZulu-Natal Research, Innovation and Sequencing Platform (KRISP), UKZN, Durban director: Tulio de Oliveira editors: Tulio de Oliveira, Katrine Anker-Nilssen and Maambele Khosa art director: Victor Hugo Szortyka graphic designers: Maambele Khosa, Ronison Guimaraes, Tulio de Oliveira, Katrine Anker-Nilssen printers: Gwynneth Louw websites: https://ceri.org.za/ https://www.krisp.org.za/, https://www.sacema.org/

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Mathematics Meets AI

Professor Jae Kyoung Kim from the Korea Advanced Institute of Science and Technology (KAIST), recently visited the School for Data Science and Computational Thinking at Stellenbosch University, presenting his fascinating research to an engaging audience.

Inspiring CREATE Conference Enhancing Genomic Capacity

The Creative and Engaged Transdisciplinary Research for Health Equity Conference (CREATE) was a unique and inspiring gathering of activists, community leaders, researchers, artists, and students.

Separations, in collaboration with CERI, hosted a workshop aiming to strengthen local capacity in vital areas: DNA isolation, quality control, library preparation, and whole genome sequencing data analysis— essential for generating and analysing genomic data.

editorial

The past two months have been exceptionally busy and rewarding, marking one of our most dynamic periods yet. This special 44-page edition of the gem covers the highlights of September and October 2025, months filled with inspiring collaborations, events, and significant achievements.

We had the privilege of hosting a senior delegation from Google DeepMind as part of a series of engagements at Stellenbosch and within the G20 Digital Innovation Alliance (G20-DIA). We have been also fortunate that one of our PhD students, Haingo Andry, was selected among 2025 Google Global PhD fellows and will be paired with Google scientists to develop his research.

Another major highlight was the first Cape HealthTech event, held at CERI in the BMRI building, which brought together entrepreneurs, innovators, researchers, investors, and healthcare leaders. With around 50 companies. The event showcased the rapid progress of the health tech and biotech ecosystem in the Western Cape. Building on this momentum, we are excited to relaunch the BRAIN Acceleration Program in partnership with OST, MIT, and the Mastercard Foundation. This one-year program will support ten of Africa’s leading start-ups in health, AI, and climate innovation, with applications open until 7 November for the 2026 intake.

Our commitment to capacity building also remains strong. This issue features the African STARS program at the Center for Africa’s Resilience to Epidemics (CARE) at the Institut Pasteur de Dakar, the African STARS Fellowship is doing more than training scientists, it’s shaping a generation of scientists, innovators, and leaders. We also partnered with Inqaba Biotech for a rare diseases bioinformatics workshop and contributed to the African BioGenome Project’s Open Institute Southern Africa Regional Workshop.

Finally, we continued producing high-impact research, including new open-access protocols for sequencing respiratory viruses such as Influenza, RSV, and Rhinovirus. Ahead of COP30, we launch the Climate Change and Epidemics 2025 Synthesis Report, produced by 200 scientists from 40 countries. The report offers compelling evidence on how climate change drives epidemics like West Nile, Dengue, and Chikungunya, while proposing actionable steps for global preparedness.

All in all, an incredibly productive and inspiring couple of months of activites that we want to share with you.

text: Tulio de Oliveira

Cape HealthTech Connect

Igniting Collaboration for Health Innovation

text: Katrine Anker-Nilssen

photos: JikaJika Media

ABOVE: LaunchLab’s Brandon Paschal.

RIGHT, TOP: The second panel, from left, moderator Maambele Khosa, Dirk Wagener, Dr Kirsten Miller-Duys, Dr Ross Rayne Vermeulen, and Kingstone Nihaka.

RIGHT: The first panel, from left, Eugene Smit, Prof Sudesh Sivarasu, Dominic Nicholas, Prof Petro Terblanche, and moderator Mandi Swanepoel.

On September 18, 2025, the Centre for Epidemic Response and Innovation (CERI), the LaunchLab, Stellenbosch Network and Innovus at Stellenbosch University welcomed a vibrant gathering of innovators at the inaugural Cape HealthTech Connect event at BMRI, Tygerberg campus. Attendees enjoyed a day filled with inspiration as a new platform was created to unite researchers, entrepreneurs, startups, and industry partners, all aimed at enriching the HealthTech ecosystem in the Western Cape for a broader impact.

In his opening keynote, Prof Tulio de Oliveira outlined the lessons learned from the pandemic, stressing that merely excelling in science is not enough. “We must change this paradigm. We need to be leaders not only in ideas, but also in production. Collaboration is essential,” he asserted. As the director of Stellenbosch University’s CERI – home to Africa’s largest biomedical and genomics facilities – he emphasised the ethical imperative of enhancing capacity development, highlighting initiatives like the African STARS Fellowship, developed in partnership with the Mastercard

Foundation. He called for proactive leadership in the development of biological countermeasures – including diagnostics, therapeutics, and vaccines.

Why is the Western Cape a focal point for biotech and health tech? Prof Tulio noted the region’s worldclass universities, well-governed cities, access to capital, and a robust entrepreneurial spirit, declaring it “the ideal environment for cultivating Africa’s biotech industry.” He urged participants to facilitate the commercialisation of biomedical science and nurture a collaborative ecosystem: “Let’s shift our focus from competition to responsiveness.” He also highlighted that this is not a vision for the future but that commercialisation of biotech is already happening with LaunchLab CERI BIO. This is the biotech incubator and accelerator in Stellenbosch, advancing ten biotech companies – many of which are already employing dozens of people and have products in the market.

The first panel discussion, moderated by Mandi Swanepoel from Wesgro, tackled the theme, “From Lab to Market in South Africa: Scaling Health Innovations for Africa and the World.” Panellists, including Dominic Nicholas from Immobazyme, Prof Sudesh Sivarasu

from the Bioengineering department of University of Cape Town (UCT), Eugene Smit from Stellenbosch Nanofiber Company, and Prof Petro Terblanche from Afrigen, shared their transformative journeys from concept to reality.

Prof Petro articulated a clear mission: “We were established not simply to develop a product, but to fulfil a purpose: localising vaccine production. Our motivation stems from the need for affordable, accessible vaccines for low-income countries.” Dominic resonated with this vision, noting his goal to move drug production to Africa, reflecting, “All drugs in Africa were imported; we wanted to change that. This mission drives us daily, and our greatest asset is our dedicated team.”

Prof Sudesh shared valuable insights on the iterative nature of MedTech innovation: “We took a bold leap with our first device for stroke patients. While it didn’t succeed, we learned immensely. The key is involving decision-makers, like clinicians, from the outset, and always focusing on the end-user.” Eugene highlighted the complexity of transitioning lab innovations to market-ready solutions: “The technical development can be straightforward; the challenge lies in effective commercialisation.”

Following the panel discussions, attendees were treated to four exciting pitches that showcased groundbreaking innovations. Khaya HealthTech’s Joel Philpott introduced a promising device for sleep

apnoea, while Prof Novel Chegou from Stellenbosch University introduced his company – which is working with LaunchLab CERI BIO to bring a biomarkerbased point-of-care TB test to the market. Tegan van der Merwe presented PhagoFlux’s innovative test for monitoring cellular health, and Louise Fourie showcased an AI-driven tool from Oncolign designed to personalise oncological treatments.

The second panel, “Global HealthTech Trends and Local Relevance: Are We Keeping Up or Outpacing?” was moderated by Maambele Khosa from CERI and featured insights from Dr Ross Rayne Vermeulen of Fluorobiotech, Dirk Wagener of Stone Three, Dr Kirsten Miller-Duys from Hyrax Bio, and Kingstone Nihaka of Plasmigene.

Kirsten emphasised the necessity of adapting technologies for rural African clinics: “The shift towards point-of-care diagnostics is crucial. Our solutions must be resilient against heat and power outages.” Dirk raised the question of customising AI: “How can we leverage our unique skills to tailor AI models for our specific needs?” Kingstone remarked on the importance of data in AI’s effectiveness, warning against increasing disparities if local contributions are lacking. “We need a robust strategy for harnessing AI effectively,” he stressed. Ross concluded, “We often reference foreign models; it’s time to embrace our local context. We can’t afford to do a five-step process to create a product. We do it in three steps. We need to operate efficiently and take pride in our resilience.”

“Merely excelling in science is not enough. We must change this paradigm. We need to be leaders not only in ideas, but also in production. Collaboration is essential”
- Professor Tulio de Oliveira

The excitement carried forward with pitches from pioneering researchers and spinouts. John Paul Makumbi from MicroBiome Solutions is developing a single test for the early detection of chronic diseases, while Amohetsoe Shale works on an affordable polycentric prosthetic knee. Dr Ross Rayne Vermeulen explores the potential of mRNA vaccines, and Simone Turner from Biocode Technologies has introduced an innovative microclot blood test for detecting hidden vascular damage – potentially benefiting long COVID patients.

The event represented a dynamic assembly of talent focused on shaping Africa’s health future, with notable attendance from the African STARS Fellowship. Kennedy Mulungu expressed his enthusiasm: “It was an honour to attend this event, witnessing over 50 HealthTech companies and startups come together to foster connections and advancements in African healthcare. The relationships I formed here highlight the immense potential for collaborative impact in this vibrant ecosystem.”

In closing, Brandon Paschal energised attendees with a call-to-action: “We are leapfrogging into the future! It’s imperative to showcase the groundbreaking work emerging from Cape Town’s health innovation sector.”

With 120 tickets sold and 150 attendees present, it was evident that a strong demand for collaborative HealthTech innovation exists. “Today was about building momentum for our initiatives, and I’m eager to see where this journey leads us,” said Brandon.

Hanli Brink (pictured below in green) from Stellenbosch Network echoed the event’s success: “This idea was inspired by our previous AgriTech Connect event. It’s exhilarating to gather entrepreneurs, innovators, researchers, funders, and healthcare leaders in one space to share knowledge and collaborate. I can’t wait to see what the next one brings.”

BRAIN 5.0: Applications Still Open!

If you are a DeepTech startup in Africa working on #Health or #Climate, applying #AI or complex hardware and ready to scale your research-driven startup and raise big, this programme is for you.

Over the past 4 cohorts, BRAIN has accelerated 40+ startups across 10 countries and 12 industries, helping 60% of them secure funding and collectively raise over $5M to take their science from lab to market.

BRAIN 5.0 focuses on market and investment readiness, bringing even more tailored support, deeper focus on health and climate ecosystems, and global exposure from Africa to the US and Europe.

Apply now, before November 7: https://www.f6s.com/brain-accelerator-5.0/apply

Disclaimer:

Startups selected as finalists will be asked to allocate a symbolic 1% equity to Open Startup (OST) to support the long-term sustainability and growth of the programme across Africa.

Learn more: https://open-startup.org/Programs/Brain

G20 Digital Innovation Alliance

The G20 Digital Innovation Alliance (G20-DIA) promote innovative digital solutions from startups in G20 countries, focusing on collaboration with industry leaders to enhance socio-economic development in Africa.

text: Tulio de Oliveira

photos: Supplied

We participated with Google and Google DeepMind on the The G20 Digital Innovation Alliance (G20-DIA), which was an initiative by the Digital Economy Working Group (DEWG) of the Group of 20, established to identify, recognise, and enable the adoption of innovative digital technologies developed by startups from G20 countries and invited guest nations.

The mission of this small and medium enterprise (MSME) competition was to address humanity’s most pressing needs across six critical sectors – through cutting-edge digital solutions that can create global population-scale impact, reduce the digital divide, and enable sustainable and inclusive techno-socio-economic development.

The G20-DIA Summit brought together top-nominated startups from each theme area to showcase their solutions to a global community of investors, mentors, corporates, and government stakeholders on the sidelines of the DEWG meeting in Cape Town, from September 26-29, 2025.

The G20 Digital Innovation Alliance was divided into six Innovation Themes:

1. Fintech

Developing and providing digital solutions that transform financial services and improve money management, access, and transfer. Your entry should address financial inclusion, streamline payments, enhance transaction security, improve credit access, or reimagine banking services.

2. Digital Platforms and AI Tools

Connecting communities through technology. This stream focuses on innovative solutions that create value by connecting multiple user groups in virtual marketplaces. Develop scalable platforms that address market inefficiencies, create new digital ecosystems, or transform industries through technology-enabled connections.

3. Secured Digital Infrastructure

Strengthening digital foundations. Looking for solutions that strengthen cybersecurity, data protection,

and system resilience in our connected ecosystem. Showcase technologies that protect digital assets, safeguard information, secure networks, or ensure business continuity during threats.

4. Circular Economy

Extending technology lifecycles. This stream seeks digital solutions that extend tech product lifecycles and reduce e-waste. Show how your innovations enable sustainable practices such as refurbishment, component recovery, equipment sharing, or resource optimisation.

5. Innovation for Development (Social Impact)

Technology for social good. Seeking digital solutions addressing critical social challenges in agriculture, healthcare, and education. Develop technologies that improve agricultural productivity, enhance healthcare access, or transform educational delivery while creating both social impact and business value.

6. Innovation for Connectivity

Bridging the digital divide. This stream focuses on digital solutions that bridge the digital divide and enhance network infrastructure for underserved communities. Develop technologies that improve internet access, strengthen telecommunications, or create affordable connectivity options.

“We are working with the G20, the presidency of South Africa and Google DeepMind and AIMS to advance AI for Science and Business development in Africa”
- Professor Tulio de Oliveira

As part of the G20 visit, a senior team from Google and Google DeepMind visited the CERi laboratories as well as CERI’S biotechnology incubator and accelerator; the LaunchLab CERI BIO in Stellenbosch. The objective was to develop collaborative ideas between Google and CERI to further collabroation and partnership.

Google DeepMind and CERI already work in collaboration with the AI for Science Masters programme in South Africa. This programme, in partnership with the African Institute of Mathematical Sciences (AIMS), provide advanced training in AI and graduates 40 mathematician and engenieers every year. Many of them do the project with CERI and work with CERI’s data team on advancing the AI programme of CLIMADE and pandemic sciences.

One of the big objectives of the advance of AI for Science in Africa is also to produce the mathematicians and engenieers needed to create AI-based business that translate some of the scientific advances into commercial opportunities. During the G20 and the visit of the Google DeepMind senior team to Stellenbosch University, Prof Tulio de Oliveira discussed further collaboration and investiment in science and business development. A follow-up visit from Google DeepMind executives is planned.

EMPOWERING AFRICAN GENOMICS

Inqaba Biotec, in partnership with CERI and Radboud University Medical Center, hosted a three-day workshop on next-generation sequencing for rare genetic disorders, uniting global experts and African researchers to advance genomic research and collaboration across the continent.

text: Katrine Anker-Nilssen

photos: Maambele Khosa

TInqaba Biotec, in collaboration with CERI and Radboud University Medical Center, held a workshop titled “Analysis and interpretation of NGS data for rare genetic disorders” from October 27 to 29, at the CERI Data Centre. The three-day event featured expert presentations from Prof Christian Gilissen and Prof Alex Hoischen, focusing on exome and genome data analysis, variant interpretation in medical genetics, and the utility of long-read sequencing.

Established in 2022 and rooted in Sub-Saharan Africa, Inqaba Biotec is a unique African genomics company whose name, meaning “rare and precious” in IsiXhosa, reflects its South African origins.

Dr Oliver Preisig, Executive Director and Co-founder, noted that Inqaba has facilitated various workshops for over 20 years. “We are a technology provider, and we recognize the need for hands-on teaching with experienced researchers in the field,” he said. “It’s wonderful to see so many people attending as this was the first workshop of its kind focused on rare diseases. Given the turnout, I can definitely see the need for more, possibly one in Gauteng next time for broader accessibility.”

Dr Preisig emphasised that the attendance of participants at a free workshop signifies true interest. “It takes time and experience to set something like this up, and most importantly, we need good, experienced speakers. We were fortunate to have Alex and Christian,” he added.

Prof Christian Gilissen, one of the speakers, studied computer science and obtained his PhD from the Department of Human Genetics at Radboud University Medical Center, focusing on identifying novel disease genes through next-generation sequencing (NGS).

He has worked on developing computational methods for analysing high-throughput sequencing data and identifying genetic causes of rare diseases and intellectual disability.

When asked about strategies for promoting genomic research and awareness of rare diseases, he mentioned the value of rare disease hackathons, where multidisciplinary teams – including clinicians, molecular geneticists, and bioinformaticians –collaborate intensively to solve long-unsolved patient cases.

Prof Gilissen appreciated the engaged participants, noting their good knowledge level. “I hope they can apply what they’ve learnt in their work and think ahead about new technologies that can aid their research or resolve patient cases,” he remarked.

Prof Alex Hoischen, leading the research group ‘Genomic Technologies and Immuno-Genomics’ at Radboud University Medical Center, was the second workshop speaker. His group made significant discoveries, including identifying disease-causing dominant de novo mutations via exome sequencing.

He emphasised that technological advancements have revolutionised the interpretation of genetic variants in rare diseases. “Our previous assessments were never complete, but we can now examine nearly all variants in a genome, which is crucial for patients with rare diseases,” he noted.

Prof Hoischen expressed enthusiasm for the interactive nature of the workshop, highlighting the

participants’ engagement and insightful questions. He encouraged inquiries of all types, asserting that no question is naïve or irrelevant. “Engaging discussions make the event exciting, and if you can achieve that, it’s usually very gratifying,” he said.

A total of 35 motivated participants attended the workshop, eager to learn, share knowledge, and foster collaboration. Rafeeqah Jacobs from A-Plus Clinical Laboratories shared her excitement about applying new skills for optical genome mapping, stating that the workshop helps lay a foundation for future testing and patient data interpretation.

Marelize Immelman from the University of Cape Town (UCT) and National Health Laboratory Services (NHLS) noted the increasing reliance on NGS in public health diagnostics, emphasising the workshop’s value in teaching how to prioritise and interpret findings.

“Connecting with people from UCT, NHLS, Inqaba, and PacBio is invaluable because we’re all working towards the same goal,” she explained.

Brent Potter from UCT found that the workshop exceeded his expectations, pointing out that the knowledge and intuitive tools gained would be invaluable in his lab. Lisa Roberts, also from UCT, expressed her eagerness to learn from the renowned speakers, intending to share the knowledge gained with her students.

NHLS’s Shrinav Dawlat cherished the opportunity to listen to and meet both speakers, appreciating the insights into their work in Europe and the connections fostered through Inqaba.

The Rare Diseases Workshop successfully brought together participants eager to expand their knowledge and skills in genomic research. The collaboration between Inqaba Biotec, CERI, and Radboud University Medical Center not only facilitated knowledge sharing among experts and attendees but also laid the groundwork for continued engagement and collaboration in advancing the understanding of rare genetic disorders in Africa.

OPPOSITE: The full Rare Disease Workshop team; participants, Dr Oliver Preisig and speakers Prof Christian Gilissen and Prof Alex Hoischen.

BELOW, LEFT: Prof Tulio de Oliveira with Inqaba Executive Director and co-founder, Dr Oliver Preisig.

“We are a technology provider, and we recognise the need for hands-on teaching with expereinced researchers in the field”
- Dr Oliver Preisig, Inqaba

Rethinking Public Health Funding and Leadership

Insights from Africa in the World 2025

text: Maambele Khosa

photos: Stefan Els and Africa in the World

The Africa in the World Festival, held from 22 to 25 October 2025 in Stellenbosch, South Africa, brought together some of the continent’s most innovative thinkers, policy leaders, and changemakers to explore solutions that can drive meaningful progress across Africa. Founded by Dele Olojede, the festival aims to create “a space of hearts and minds,” where rigorous ideas meet deep reflection to spark sustainable change. Olojede remind us that “Africa exists in the world. Africa is not one colour. Africa is not even one place.” This spirit of diversity and unity framed the week’s discussions, spanning digital innovation, health equity, governance, education, and the arts.

“What Now? With the US in Retreat”: A Conversation on Public Health Funding

A deeply relevant panel discussion took place at Spier Wine Farm at 9:30 AM on 23 October, exploring the question: “What now? With the US in retreat, new thinking around funding public health.” The session, moderated by Prof. Tulio de Oliveira, Director of the

Centre for Epidemic Response and Innovation (CERI), featured Prof. Ntobeko Ntusi, President and CEO of the South African Medical Research Council (SAMRC), and Prof. Novel N. Chegou, immunologist and head of the Tuberculosis Diagnostic Biomarker Research Group at Stellenbosch University.

With the dismantling of USAID and cuts to global health funding, the panel examined what these shifts mean for Africa’s scientific and health ecosystems. Prof. Ntusi shared sobering statistics, noting that over 600 research grants and thousands of medical professionals were affected, with an estimated R1.85 billion loss in funding and a R728 million shortfall for 2025 alone.

“The repercussions are not only for the current research, but also for the next generation, we risk losing a generation of scientists without access,” said Prof. Ntusi.

He outlined how the SAMRC has raised over R2 billion to stabilise research priorities, infrastructure, and early-career support, while establishing the SAMRC Foundation to diversify income streams and strengthen long-term resilience.

Prof. Chegou echoed the urgency, highlighting how the cuts triggered both “panic and perseverance” across institutions. “This challenge is pushing us to diversify and reduce reliance on single sources of funding,” he said, noting that his team continues to apply for a record number of new grants.

He also underscored ongoing challenges for young and early-career African researchers, particularly regarding visa access to study and work in South Africa.

Beyond Funding: Building Resilient African Research Ecosystems

Moderating the discussion, Prof. de Oliveira reflected on the broader opportunity presented by this moment of crisis: “Africa is not poor, we must become key drivers of our own research ecosystem.”

He emphasised that resilience depends not only on funding diversification but also on reimagining African research institutions as sustainable enterprises through innovation, local manufacturing, and value creation. Citing initiatives such as LaunchLab CERI-Bio

and partnerships linking research to ISO-accredited laboratories, he highlighted models generating both scientific and economic returns.

The panel also explored pathways for scientific sovereignty, from building local vaccine manufacturing capacity and protecting intellectual property to simplifying visa processes and fostering collaboration across African borders.

“African researchers have long slept on borrowed mats, we must create value for our own science and industry,” one audience member noted, encapsulating the mood in the room.

The discussion closed with a shared call for African-led collaboration across governments, private sectors, and academia to build a science ecosystem capable of sustaining itself amid global uncertainty.

New Ways of Leading: Keynote by Dr David Moinina Sengeh

Dr David Moinina Sengeh, Chief Minister and Chief Innovation Officer of the Government of Sierra

ABOVE: Dr David Moinina Sengeh, Chief Minister and Chief Innovation Officer of the Government of Sierra Leone and Prof. Deresh Rajugernath, Rector and Vice-Chancellor of Stellenbosch University

Leone delivered a keynote on the same evening at Stellenbosch University’s JH Mouton Building, Titled “On New Ways of Leading: Modern African Political Leadership”, Dr Sengeh drew on his experience in governance, technology, and education to emphasise the need for creativity, empathy, and inclusivity in leadership.

“We need leadership that inspires hearts and minds, one that is moral, visionary, inclusive, and deeply human. We need rekindled hope to move forward together,” he said.

The session was opened by Prof. Deresh Rajugernath, Rector and Vice-Chancellor of Stellenbosch University, who welcomed attendees and shared the SU Vision 2040 of becoming an Africa-leading, research-intensive university committed to advancing knowledge in service of society, contributing to solutions for grand challenges such as climate change, food security, and inclusive education.

Dr Sengeh’s address complemented the earlier panel discussion, reminding participants that leadership, innovation, and inclusive policy are central to Africa’s future, whether in science, governance, or social development.Through the panel and keynote, the Africa in the World Festival 2025 reinforced its mission: uniting Africa’s thinkers and doers to craft actionable, lasting solutions, and to empower the next generation of scientists, leaders, and innovators.

“We need leadership that inspires hearts and minds, one that is moral, visionary, inclusive, and deeply human. We need rekindled hope to move forward together”
- Dr David Sengeh

Join Us for the Launch of the CLIMADE COP30 Report

Climate change is no longer a distant threat, it’s already reshaping the world around us, intensifying extreme weather events, and disrupting ecosystems. Yet one of its most profound impacts is often overlooked: its growing influence on infectious diseases.

Join the CLIMADE Consortium for the live launch of our COP30 Report, which highlights the urgent need to understand and address the climate drivers behind disease emergence and spread. This special event brings together leading scientists, partners, and voices from across the globe who are working to predict, track, and control diseases and epidemics in the world’s most affected regions.

The report underscores a simple truth: Addressing the intersection of climate change and infectious diseases is no longer optional, it’s essential for global health security.

Whether you’re a researcher, policymaker, health professional, or citizen passionate about a healthier, more resilient future, this launch is an opportunity to engage with evidence, action, and hope.

Let’s bring this conversation to the forefront, and to the attention of those who can drive lasting change.

Save the Date: Thursday, 6 November, 2025 15:00 SAST | 13:00 GMT

Register to get a reminder: https://forms.office.com/r/XdHkRyc0RP

Watch Live link: https://youtube.com/live/o9INgkFTb9E?feature=share

African STARS, African Solutions

Inside a fellowhship shaping scientists, innovators, and leaders for the continent in Dakar, Senegal.

text: Demba Gueye

photos: Libasse Al Arbi Ndoye

At the Center for Africa’s Resilience to Epidemics (CARE) at the Institut Pasteur de Dakar, the African STARS Fellowship is doing more than training scientists –it’s shaping a generation. In the labs where sequencers hum and ideas spark, the fellowship blends science, systems thinking, and leadership to build capacity that stays on the continent and produces solutions designed by –and for – Africans.

Here, weeks feel like accelerators. In a single module, fellows can move from genomic sequencing to discussions on continental surveillance strategy.

As fellow Richmond Gorman recalls, “Week 4 … focused on genomic surveillance, sequencing, pathogen discovery, and bioinformatics.” The sessions, led by experts from the Institut Pasteur de Dakar, turn theory into practice: how to detect, characterise, and track pathogens faster – and how to turn those findings into action. “It was also great to learn more about the strides that WHO, Africa CDC, and Institut Pasteur de Dakar have made in pathogen genomic surveillance,” he added, emphasising the link between science and systems.

That bridge between knowledge and implementation lies at the heart of African STARS. Its Advanced and Translational Training (ATT) pathway pushes fellows to move discoveries from bench to bedside – and beyond.

For Arona Sabène DiaPa, beginning the journey comes with both humility and determination: “I am humbled to be part of this programme designed to strengthen the continent’s resilience to epidemics and empower the next generation of scientists.”

This is next-generation leadership in action – a curriculum that sees

scientists not only as researchers but as builders of public trust and resilience. The programme’s approach reflects a simple conviction: Africa already has the talent. What’s needed is sustained investment, infrastructure, and mentorship rooted in African realities.

At the same time, the fellowship advances the idea of African-led solutions. Its focus on genomics, diagnostics, and vaccines positions the continent not as a recipient of technology, but as an originator. Fellows learn how to navigate regulatory frameworks, manage data responsibly, and design tools that match local needs. Every dataset and pipeline movement serves a larger vision: scientific sovereignty and preparedness.

That vision is also inclusive. Women scientists and professionals are visible, vocal, and leading change. As fellow Edna Housna expresses, “Throughout this journey, my goal is to become a multifunctional, resilient, and adaptable researcher, ready to respond to the complex health needs of our continent, because in every crisis, we must recognise that there is danger and opportunity.” Her words capture the fellowship’s ethos –one that transforms uncertainty into innovation and diversity into collective strength.

Beyond the lab, the programme’s

ripple effects are visible: stronger public-health networks, new job opportunities in biomanufacturing, and a growing culture of collaboration among African institutions. The fellowship teaches its participants to build phylogenetic trees – but also to build coalitions. It pairs technical mastery with communication, policy, and entrepreneurship, ensuring that scientific discoveries reach the people who need them most.

Capacity building, leadership, inclusion, and impact converge here in one narrative: a continent investing in its own future. As these fellows learn to decode genomes, they’re also decoding a new paradigm for African science – one rooted in excellence, equity, and ownership. From Richmond’s hands-on lab work to Arona’s sense of duty and Edna’s resilience, the message is clear: Africa’s health security will be written, sequenced, and led by Africans.

CAPTIONS

OPPOSITE PAGE, TOP: The IPD African STARS Fellowship opening. OPPOSITE PAGE, LEFT: Hounsa Edna Emérite, Mary W. Muroki, and R.N. Levi Hosea.

OPPOSITE PAGE, RIGHT: Ousmane Sadio, Arona Sabène Diatta, Issa Sy, Richmond Gorman, and Safiétou Sankhe (front). BELOW: Richmond Gorman.

Adapting the Illumina COVIDSeq for Whole Genome Sequencing of Other Respiratory Viruses

Open access publication and protocol on the adapatation of DNA sequencing protocols for use with Influenza A/B, Respiratory Syncytial Virus (RSV), and Rhinovirus

Authors: Nqobile Mthembu, Sureshnee Pillay and Colleagues

Journal: LabMed 2025, 2(4), 19; https://doi.org/10.3390/

Acute respiratory infections (ARIs) continue to pose a major global health threat, particularly among vulnerable populations. These infections often present with similar clinical symptoms, complicating accurate diagnosis and facilitating unmonitored transmissions. Genomic surveillance has emerged as an invaluable tool for pathogen identification and monitoring of such infectious pathogens; however, its implementation is frequently limited by high costs.

The widespread use of highthroughput sequencing during the COVID-19 pandemic has created an opportunity to repurpose existing genomic platforms for broader respiratory virus surveillance.

In this study, we evaluated the feasibility of adapting the Illumina COVIDSeq assay – initially designed for SARS-CoV-2 wholegenome sequencing – for use with Influenza A/B, Respiratory Syncytial Virus (RSV), and Rhinovirus. Positive control samples were processed using two approaches for library preparation: four virus-specific multiple workflows and a combined rapid workflow. Both workflows incorporated pathogenspecific primers for amplification and followed the Illumina COVIDSeq protocol for library preparation and sequencing.

Sequencing quality metrics were analysed, including Phred scores, read length distribution, and coverage depth. The study did not identify significant differences in genome coverage and genetic diversity metrics between workflows.

Genome Detective consistently identified the correct species across both methods. The findings of this study demonstrate that the COVIDSeq assay can be effectively adapted for multi-pathogen genomic surveillance and that the combined rapid workflow can offer a cost- and labourefficient alternative with minimal compromise to data quality.

The described workflow is streamlined and adaptable, incorporating an initial amplification step that facilitates rapid protocol modification for a broad range of viral pathogens across all Illumina sequencing platforms. Its versatility has been demonstrated in various studies: for dengue virus on the NovaSeq 6000, the NextSeq 1000/2000, the MiSeq and the iSeq. We have also adapted COVIDSeq for chikungunya virus on the MiSeq; for HIV drug resistance monitorin; for mpox; and hence can be adapted for a range of pathogens provided the use of highly sensitive primers which can then be run on any Illumina platform.

Our findings indicate that adapting this protocol for other respiratory viruses did not reduce the data quality. This is supported by the comparable Phred scores (>30) observed for both SARS-CoV-2 and other respiratory samples that were library prepared using the COVIDSeq assay, reflecting an error rate of 1 in 1000 base calls, or a base call accuracy of 99.9% . Similar Phred score thresholds (>30) have also been accepted in respiratory virus studies focusing on Influenza [55,56]. Furthermore, this assay was compatible with other respiratory viruses, as we obtained read lengths suggested by the Illumina COVIDSeq Kit (Catalogue No. 20065135, San Diego, CA, USA)

for all respiratory samples. Other studies have also successfully adapted COVIDSeq for respiratory viruses like RSV, obtaining highquality genomes and enabling researchers to explore the genetic variability of the seasonal viruses. These standardisation attempts of NGS technology and protocols are essential, as they will allow application in clinical laboratories for routine practice at an affordable cost and play a vital role in diagnosing respiratory diseases, developing more appropriate treatment, and keeping surveillance of emerging viruses in the near future.

OPPOSITE PAGE: Figure 1 – Sample preparation and sequencing of multiple respiratory viruses in multiple workflows, indicated by four tubes, and a combined rapid library preparation workflow, indicated by one tube, the different colours indicating different viruses. (A) indicates the multiple library preparation workflow. (B) indicates the rapid combined library preparation workflow.

Access OPEN publication and protocol:

Mthembu, N.; Pillay, S.; Musopole, H.T.; Naidoo, S.J.; Msomi, N.; Baye, B.C.; Tshiabuila, D.; Memela, N.Z.; Tombo, T.; de Oliveira, T.; et al.

Adapting the Illumina COVIDSeq for Whole Genome Sequencing of Other Respiratory Viruses in Multiple Workflows and a Single Rapid Workflow. LabMed 2025, 2, 19.

https://doi.org/10.3390/ labmed2040019

“The

Korean Embassy plan and organise a series of special lectures delivered by Korean experts, with the aim of laying a cornerstone for more substantial and sustainable cooperation between the two countries – by strengthening networks among researchers in various fields.”

– H.E. Dong-han Yang,

Ambassador of the Republic of Korea to the Republic of South Africa

Mathematics Meets AI

A Visit from Professor Jae Kyoung Kim

text:

The School for Data Science and Computational Thinking

photos: Ignus Dreyer

How can mathematics and artificial intelligence work together to make us healthier and happier?

This question was asked by Professor Jae Kyoung Kim from the Korea Advanced Institute of Science and Technology (KAIST), who presented at the School for Data Science and Computational Thinking at Stellenbosch University. He shared his research on “Mathematics Meets AI: Modeling Time-series to Transform Human Health and Society.”

Prof Kim’s visit was facilitated by the Embassy of the Republic of Korea, Stellenbosch University International, and the school. Professor Kim leads the Biomedical Mathematics Group at the Institute for Basic Science (IBS) in Korea and holds adjunct appointments at Korea University’s Medical School and New York University. His visit brought together students, researchers, and staff from across the university who share an interest in the power of data and computation to answer pressing questions about human well-being.

Prof Kim used simple mathematics and AI methods to ask deep questions. “Mathematics and AI are

not just tools – they are powerful languages that can help us solve some of humanity’s biggest health challenges,” he said.

Understanding Disease Through Data

One of the examples in Prof Kim’s talk tackled a problem that has puzzled researchers for years: How exactly does climate affect the spread of dengue fever? Using an approach called General ODEBased Inference (GOBI), his team has found new ways to detect causeand-effect relationships in complex time-series data. Their analysis shows that rainfall and temperature influence dengue outbreaks, but the effect changes from one region to another, depending on the regularity of rainfall.

This breakthrough, published in Nature Communications (2023) and Science Advances (2025), could help shape more responsive public-health policies in countries vulnerable to mosquito-borne disease. It is a vivid reminder of how maths can do more than describe the world, it can help us manage it.

Rethinking Sleep and Alertness

Prof Kim then shifted from mosquitoes to sleep a topic that affects everyone. His team

discovered that simply sleeping seven to nine hours a night does not guarantee alertness. By combining mathematical models of sleep pressure and circadian rhythm with data from wearable devices, they can measure whether each night’s sleep is truly sufficient.

This research, done in collaboration with medical scientists at Samsung Medical Center and Korea University, led to a practical outcome: an algorithm that can be used to track daily sleep sufficiency.

Beyond better sleep tracking, the same mathematical insights are helping predict mood changes and mental-health episodes using only sleep-wake data.

It is a great example of a mathematical biology model that can be deployed inside a commercial wearable to increase happiness and alertness.

Making Sense of Antibiotic Resistance

In the final part of his talk, Prof Kim addressed another global challenge: why antibiotics sometimes fail.

His group used a new AI-driven method, the Density-Physics Informed Neural Network (Density-PINN), to peer into what he calls “black-box” biological processes. By analysing the timing of cellular responses, they found that the reason antibiotics sometimes don’t work lies in the diversity of bacterial behaviour at the microscopic level.

This work, published in Cell Patterns (2024), demonstrates that different bacteria respond to antibiotics with varying delays, some quickly, others much later. Understanding these timing differences could guide the design of more effective treatments.

PREVIOUS PAGE: The Ambassador of the Republic of Korea to South Africa, Dong-han Yang, greets Randall Adams, with Prof Kim at the back.

LEFT: Participants at the the School for Data Science and Computational Thinking presentation.

BELOW: The Ambassador of the Republic of Korea to South Africa, Dong-han Yang, Prof Kim, and Prof Kanshukan Rajaratnam.

Building Bridges Through Science

Prof Kim’s visit was not only about equations and algorithms. It was also about collaboration. He invited students and researchers to explore opportunities in Korea through programmes such as the K-Brain Visiting Scholar Program, KAIST Jang Young Sil Postdoctoral Fellowship, and the Global Korea Scholarship for researchers, postgraduate, and undergraduate students.

His talk underscored the shared vision between KAIST and Stellenbosch University: that data, computation, and human curiosity together can transform the way we understand health, society, and the environment. “Collaboration across countries and disciplines is essential if we want to make real impact on health and society,” said Prof. Jae Kyoung Kim.

As the seminar concluded, one message stood out clearly. Mathematics and AI are not just computational tools, but they are languages through which we can understand life itself.

The Director of the School, Prof Rajaratnam reflected on the visit, “For the School for Data Science and Computational Thinking, this visit was another step in building global connections and showcasing how transdisciplinary research, linking researchers mathematics, health, and AI as well as industry/community partners, can help solve some of humanity’s most complex problems.”

We are grateful to the Embassy of the Republic of Korea and Stellenbosch University International in facilitating this visit.

Strength Through Diversity

Celebrating Heritage Day at KRISP

At KRISP, Heritage Day is a celebration of the diversity that defines both our team and our science.

South Africa is often described as a “rainbow nation,” and our team is a living reflection of that vibrant tapestry. From multiple cultures, languages, and histories, we bring together voices that are distinct yet complementary. It is this very diversity that fuels creativity, strengthens collaboration, and sparks innovation in our laboratories. By combining different worldviews, we unlock fresh ideas and solutions that move genomics and public health research forward.

This year, the celebrations were as educational as they were festive. On Friday we shared a spread of traditional foods and hosted a series of short presentations showcasing the wide range of our heritages. These included the history of biltong and the many types of pap enjoyed across Southern Africa,

insights into Venda and Zulu customs, traditional Zambian garments, traditional deep-fried delicacies from Cape Town, Henna tattoo art, and the meaning behind the Hindu bindi. Our Grant’s Manager, Zuzana Naidoo, also offered a glimpse into Slovakian history and traditions from her upbringing, reminding us that our community is global as well as local.

The celebration not only highlighted our differences but also reinforced our shared purpose: advancing science that benefits communities in South Africa and beyond.

Reflecting on the day, Dr Jennifer Giandhari remarked, “We are proud to be part of such a vibrant community where every story adds to the collective strength of our team.”

As we marked Heritage Day, KRISP reaffirmed its commitment to diversity and inclusion as essential drivers of discovery.

HIV Drug Resistance

Global Dialouge at Virtual Conference

At the beginning of September, members of the KRISP team took part in the International Workshop on HIV Drug Resistance and Treatment Strategies Virtual Conference, where they shared new insights as part of the DTG RESIST Study Group.

Dr. Jennifer Giandhari and Shirelle Naidoo presented posters showcasing their latest research. Dr Giandhari’s work examined mutations in the 3’ polypurine tract of nef that may influence dolutegravir efficacy, while Naidoo presented on the detection of low-frequency integrase inhibitor resistance mutations using next-generation sequencing. The KRISP team, led by Dr Richard Lessells, contributed to four other poster presentations and one oral presentation from the DTG Resist study. These contributions highlight KRISP’s commitment to understanding how resistance emerges and evolves in different HIV-1 subtypes across Africa.

Reflecting on the experience, Dr Giandhari noted: “The conference, although virtual, felt very close knit with several promising opportunities to collaborate further.” Shirelle Naidoo added: “I found the conference to be very beneficial because the topics covered were very relevant to our study group, with useful discussions around laboratory work and methodology.”

“The conference offered promising opportunities for further collaboration.”

– Dr Jennifer Giandhari, KRISP

The conference also featured a keynote address by Professor Tulio de Oliveira, who spoke on advances in pandemic genomic surveillance and the importance of maintaining strong surveillance systems for HIV drug resistance to support the global HIV response.

His talk was warmly received and underscored KRISP and CERI’s leadership in applying genomics to epidemic control.

This workshop followed on the heels of KRISP’s participation at the 13th IAS Conference on HIV Science (IAS 2025) in Kigali this past July. There, the same team presented another DTG RESIST poster comparing Sanger and Illumina sequencing to detect resistance mutations, contributing to a programme that featured over 1 400 scientific posters and 142 oral abstracts.

Together, these presentations reinforce KRISP’s role in global HIV research collaborations, advancing knowledge that informs global treatment and monitoring strategies. Well done to our team and all collaborators across Africa and around the world who continue to drive this important work forward.

CREATE Conference

Fostering Health Equity Through Creativity and Collaboration

text:

Nicala Zeeman, Dr. Chanelle Mulopo, Ameera Crew & Gwynneth Louw

photos: Supplied

Creativity, artistic performances, intentional manifestos, community engagement. These are not the typical things you think of when attending a conference. However, the inaugural CREATE Conference was anything but ordinary. Taking place from 30 Sept - 2 Oct 2025 at the Biomedical Medical Research Institute (BMRI) at Tygerberg Campus, the Creative and Engaged Transdisciplinary Research for Health Equity Conference (CREATE) was a unique and inspiring gathering of activists, community leaders, researchers, artists, and students with one aim in mind: use creativity, innovation, and collaboration to address issues of health equity and revolutionise how we think about research on health equity.

Below we share reflections from CERI team members who attended the conference.

Nicala Zeeman, Public Squares Project Administrator & member of CREATE Conference organising committee

Having the opportunity to attend the CREATE Conference 2025 was an inspiring and thoughtprovoking experience. Unlike traditional academic gatherings, this conference centred around creativity, inclusion, and collaboration as essential aspects for health equity. Something which stood out to me was the manifestos which were created throughout the conference. These manifestos focused on the voices of artists, researchers and community members. The phrases included in these manifestos were led by “We need …” – assisting researchers in including the needs of all in their research.

Having these manifestos in collaboration with the different types of data collection methods – such as storytelling, theatre, photovoice, and participatory designs –showcased art as a powerful source of data and dialogue.

Taking into consideration the context of the conference, it showcased alternative ways to have voices heard whilst also creating a space for inclusion between academics, artists, and community members. Overall, the conference stood apart as it incorporated live poetry, live musical items, immersive art therapy activities, and fashion as a means of expression.

Gwynneth Louw (pictured, left), Research Administrator at the Centre for Epidemic Response & Innovation (CERI) & volunteer at the CREATE Conference

The CREATE Conference was an inspiring event that blended science and creativity in meaningful ways. Attending as a delegate, artist, and volunteer, I found

every session rich with insight and connection. My main motivation was to explore how creativity could enhance scientific engagement within communities, and the experience exceeded all expectations.

Among the most memorable moments was sharing my poetry alongside Associate Professor Nicola Plastow, who accompanied me on the drum, creating a shared story that embodied collaboration and spontaneity. Each session I attended was engaging and filled with innovative ideas about community engagement in academia. The DRUMBA session stood out as particularly dynamic and uplifting, reminding me how art and rhythm can foster unity and learning. What struck me most throughout the conference was the emphasis on community, particularly being seen, heard, and included. I left with a renewed appreciation for the balance between science and art, realising that collaboration is not only powerful but essential for progress. The experience has inspired me to bring these lessons back into my community projects and to continue building spaces where creativity and research coexist harmoniously.

Dr Chanelle Mulopo, Researcher at the Centre for Epidemic Response & Innovation (CERI)

The CREATE 2025 Conference was exceptionally well organised and offered a fresh arena of ideas that sparked a great deal of creativity. The sessions and interactions challenged me to think beyond conventional research approaches, particularly in how I engage with communities and incorporate more creative and participatory methods.

A key highlight for me was the body mapping workshop facilitated by Lynette Rademeyer-Bosman. The practical

and reflective nature of the session encouraged me to reimagine how I can integrate creative visual methods into my research practice. It was both inspiring and empowering, and I left with a renewed sense of curiosity and motivation to experiment with innovative approaches that make research more inclusive and expressive.

Ameera Crew, Public Squares Intern & member of CREATE Conference organising committee

The CREATE Conference was a truly inspirational gathering that gave a breath of fresh air to research on health equity. In the opening statement, the conference chair, Prof Lynn Hendricks, encouraged delegates and presenters to embrace creativity and authenticity in research. This was a golden thread throughout the conference as showcased in the unique ways people were conducting research whether through play, music, and theatre, or by going beyond academia and involving religious leaders, community pioneers, and youth.

For me, the highlight of the conference came on the final day. I attended a workshop on the importance of breastfeeding for babies, mothers, and society. The presenter addressed common misconceptions regarding breastfeeding versus bottle-feeding and uncovered some of the practices that are deemed as normal but are actually rooted in systems of inequality. Breastfeeding is a holistic approach to nurturing that extends beyond nutrition, connecting various aspects of well-being. I left the session feeling both enlightened and empowered to consider how small, intentional acts in research and practice can contribute to broader systems of equity and care.

ABOVE: Lasec’s Chantal Hauptfleisch.

TOP: Business Development Manager at Lasec, Naledi Plaatjies, presenting at the second seminar.

fellows,

UNLOCKING INNOVATION IN AFRICA

The 2025 CERI Summer Scientific Seminar Series

text: Katrine Anker-Nilssen

photos: Maambele Khosa

LEFT,
LEFT: African STARS
Dr Alex Nka and Harries Molepo.

The Centre for Epidemic Response and Innovation (CERI) has launched its highly anticipated 2025 Summer Scientific Seminar Series, designed to elevate knowledge and foster collaboration among the African STARS fellows. This unique initiative, led by Dr Richard Gordon, is a vital extension of the fellows’ training, aligning closely with key teachings from the LaunchLab focused on entrepreneurship in the scientific field.

The series aims to empower innovators with a broader understanding of the business and operational landscape in Africa. “We want to ensure our fellows comprehend not just product development, but also the essential components of building successful ventures,” emphasised Dr Richard Gordon. With a total of eight seminars planned, the final session is yet to be confirmed.

The inaugural seminar, titled Drug Discovery & Designing, kicked off on Thursday, September 25, and focused on the crucial role that governments play in fostering a science-based economy. It highlighted strategies to enhance Africa’s capabilities in drug discovery through collaborative efforts across the continent. The seminar attracted 170 participants both in person and online, underscoring the widespread interest in the subject. Featuring distinguished speakers – Glaudina Loots, Director of Health Innovation at the Department of Science and Innovation (DSTI), as well as John Woodland and Dr Susan Winks from H3D, a leading African Drug Discovery and Development programme – the seminar captured the audience with insights on the intersection of policy, science, and collaboration. “Government has such an

important role in creating a fertile environment for science startups,” remarked Dr Richard Gordon. “Without governmental support, very few of them can get off the ground, as international philanthropy typically does not fund emerging startups.”

The remarkable journey of H3D, which began as a government initiative over 15 years ago and has since evolved into a robust research hub of 75 personnel working on developing treatments for malaria, serves as a source of inspiration. The narrative of H3D’s growth illustrates how expertise has been cultivated and mobilised over the years.

Prof Tulio de Oliveira, CERI’s director, praised H3D’s impactful work: “Their efforts in advancing drug development for neglected diseases in Africa truly motivated our African STARS fellows. They demonstrated that leadership can emerge from Africa itself.” He highlighted the significance of South Africa’s investment in the bio-economy and the transfer of scientific knowledge to produce vital biological solutions – including diagnostics, therapeutics, and vaccines.

Online participant Dr Chernet Gebru, hailing from Ethiopia, raised a crucial concern regarding the resource-intensive nature of drug discovery –inquiring about how African institutions could collaborate to pool resources and expertise, making discoveries accessible and affordable for African populations. Dr Susan Winks responded by introducing the GC ADDA network, aimed at connecting researchers with varied expertise to collaborate on drug discovery projects. She also highlighted ongoing partnerships with organisations like The International Federation of Pharmaceutical Manufacturers and Associations (IFPMA) to strengthen ties with the industry, particularly in addressing the

capital-intensive challenges of drug development in Africa.

The second seminar, held on Thursday, October 2, delved into the challenges and opportunities surrounding Medical Devices and Diagnostics in Africa. This session also drew a significant audience, with approximately 150 participants in attendance.

Dr Lyndon Mungur, CEO and Founding Member of Medical Diagnostech, shared insights on the realities of manufacturing diagnostics within the continent. Concurrently, Naledi Plaatjies, Business Development Manager at Lasec, provided an overview of the company and discussed the complexities of market access and supply chains in Africa, referencing both successful and unsuccessful market entry case studies.

Focusing on the medical device and diagnostic industry, Dr Lyndon Mungur addressed the challenges encountered in setting up a manufacturing facility in South Africa. “He spoke about the obstacles they’ve faced, as well as the critical importance of regulation, facility accreditation, and sound business planning,” noted Dr Richard Gordon.

Lasec added another layer of understanding to the discussion by sharing their experiences as a well-established supplier in the industry, touching on the subject of logistics and regulatory compliance while servicing over 30 African countries. “This second seminar prompted extensive discussions on regulations, product ideation, and the logistics of shipping – truly an engaging session,” concluded Dr Richard Gordon.

The remaining seminars in this series continue to illuminate vital issues shaping Africa’s healthcare landscape and drive innovation across the continent.

STELLIES Students Shine

Google names two SU students, Haingo Andry and Simon Malan, among its 2025 Global

PhD fellows

text: Anél Lewis

photos: Maambele Khosa

Two Stellenbosch University (SU) students, Haingo Andry and Simon Malan, have been named among the recipients of the prestigious 2025 Global Google PhD Fellowships.

These fellowships recognise outstanding graduate students who are conducting exceptional and innovative research in computer science and related fields.

The applications are evaluated on the strength of the research proposal, research impact, student academic achievements, and leadership potential. Two Stellenbosch University (SU) students, Haingo

Andry and Simon Malan, have been named among the recipients of the prestigious 2025 Global Google PhD Fellowships.

These fellowships recognise outstanding graduate students who are conducting exceptional and innovative research in computer science and related fields, specifically focusing on candidates who seek to influence the future of technology.

Through the programme, fellows receive direct financial support for their PhD studies and are paired with a dedicated Google Research Mentor.

“We are excited to welcome this global cohort and look forward to partnering with them as they continue to become leaders in their respective areas,” said the Google PhD Fellowship Team.

Prof Sibusiso Moyo, SU’s Deputy Vice-Chancellor: Research, Innovation and Postgraduate Studies, said: “We are really proud of our two PhD students, Haingo Andry and Simon Malan, for the award, and of their supervisors who are supporting them to pursue their studies with excellence in research and commitment to knowledge transfer.”

Andry, who is based at SU’s Centre for Epidemic Response and Innovation (CERI) within the School for Data Science and Computational Thinking, says he was honoured to receive the fellowship which will enable him to deepen his research. “It offers research support and mentorship that will help me pursue more ambitious and innovative ideas,” he says.

His supervisor, Dr Houriiyah Tegally, Head of Data Science at CERI, says: “We are thrilled to see Andry’s work recognised in the form of this prestigious award. He brings advanced AI expertise to our data science team at CERI investigating the impacts of climate change and climate disasters on infectious diseases in Africa.

Andry’s doctoral work focuses on climate-driven human migration, using data-driven methods to model displacement during extreme weather events. “The aim is to create tools that can help strengthen public health and epidemic preparedness,” says Andry. Tegally adds: “This research is the first of its kind, leveraging satellite imagery to study climate induced migrations in vulnerable regions of Africa, and investigating how this will impact exposure to certain infectious diseases.”

Another SU student recognised for his pioneering work is Malan, currently in his second year of a Master’s degree in electrical and electronic engineering. He is researching how computational models can learn words from a language purely by listening to speech in that language.

Being accepted into the Google PhD Fellowship Program is a great privilege, he says. “Of course, the name ‘Google’ speaks for itself, and although slightly daunting, it is mostly very exciting. This fellowship allows me to continue exploring my field of research, for which I have developed a deep passion.”

He attributes much of this to his supervisor, Prof Herman Kamper, “whose own passion, enthusiasm,

and expertise have inspired me to truly care about the research at hand”. Furthermore, Malan adds: “I would like to thank Google for supporting my research. It is a great privilege to be in this position, and I am determined to make the most of it.”

Kamper, who was the recipient of the Google Faculty Award in 2018 and 2019, says Malan’s exceptional performance during his Master’s studies, including the presentation of a paper at a premier global conference during his first year, made him a strong candidate for the fellowship.

“Even strong PhD students struggle to get an international publication from work in their first year, so this shows that Simon is an exceptional student with the capacity for independent research,” Kamper notes.

Kamper adds that the fellowship would allow Malan to remain at Stellenbosch University to pursue his PhD. “Any international group would have been happy to have him, so we are fortunate to have him here to continue making both local and international contributions.”

The applications are evaluated on the strength of the research proposal, research impact, student academic achievements, and leadership potential. According to Google, research proposals are evaluated for innovative concepts that are relevant to Google’s research areas, as well as aspects of robustness and potential impact to the field.

ENHANCING GENOMIC CAPACITY

A SUCCESSFUL SOUTHERN AFRICA WORKSHOP FOR THE AFRICAN BIOGENOME PROJECT

text: Katrine Anker-Nilssen

photos: Supplied

In September, Separations, in collaboration with CERI, hosted the African BioGenome Project (AfricaBP) Open Institute Southern Africa Regional Workshop, organised and funded by Separations. Facilitated by Natasha Kitchin and Jacques Potgieter from Separations, the workshop aimed to strengthen local capacity in vital areas: DNA isolation, quality control, library preparation, and whole genome sequencing data analysis—essential for generating and analysing genomic data.

The workshop combined theoretical knowledge with practical applications, covering DNA extraction, quality control using spectrophotometry and fluorometry, and foundational principles of library preparation and data analysis. “This aligns closely with AfricaBP’s mission to empower African scientists to generate and analyse genomic data within the continent,” Natasha explained.

Workshop sessions fostered active participation, with attendees sharing experiences, troubleshooting techniques, and discussing applications in their research contexts. Many questions cantered on improving DNA quality from challenging sample types and developing sequencing libraries for various platforms. A standout moment was witnessing participants gain confidence and independently complete DNA extraction and quality control by the workshop’s conclusion. The facilitators created a wellstructured program, offering detailed handouts on DNA isolation and quality control, thoroughly reviewing protocols, and designing

engaging data analysis exercises. “Although keeping to the schedule was a squeeze, the enthusiasm and collaboration from participants made the experience overwhelmingly positive,” Natasha noted.

CERI provided excellent logistical support, ensuring smooth lab setup and timely material access. Lavanya Singh, Head of Laboratory at CERI, highlighted their commitment to advancing genomics research in Africa. She mentioned initiatives like the African STARS Fellowship aimed at cultivating the next generation of scientific leaders. “Partnerships and events like the AfricaBP workshop provide essential tools to promote innovation and nurture transdisciplinary research across the continent,” she added.

Addressing the challenges in African genomic research, Jacques pointed out that limited infrastructure and technical expertise remain significant obstacles. Workshops such as this provide crucial handson experience and help build a network of trained researchers throughout Africa. He encouraged participants to integrate the techniques learned into their research environments, noting plans for more advanced sequencing and data analysis sessions in the future.

Lavanya reiterated AfricaBP’s vision to leverage biodiversity genomics for sustainable management on the continent. She acknowledged that while genomic research in Africa holds immense potential—improving health outcomes and spurring innovation—it also confronts challenges like inadequate funding and a shortage of

skilled personnel. “Workshops like this can address these issues by enhancing capacity and encouraging local knowledge transfer,” she said.

Jacques emphasised the inspiring coordinated effort of the AfricaBP project to generate valuable genomic data tailored to African challenges, fostering opportunities for local leadership in the field.

“Collaboration and continuous training are essential to making this a sustainable reality,” Natasha concluded, reinforcing the urgency for utilising available resources in genomics research. “It’s here, and it’s now,” Lavanya added, affirming that Africa is wellequipped to lead in this vital area.

Participant Feedback:

“So grateful to have shared this valuable learning journey with you.”
– Ezintle Madiba
“Thank you so much. It was an amazing time of learning.”
– Dr Olufunto Fanaro
“Thank you to Natasha, Jacques and the team for putting together such a well thought-out and impactful workshop. I am very thankful to have met such cool and knowledgeable scientists.”
– Realeboha Lesedi Nkoe

Inspiring Future Scientists

University of Limpopo students visit KRISP

text and photos: Paul Harris

KRISP was delighted to recently welcome 58 students from the University of Limpopo’s School of Molecular and Life Sciences for a tour of our laboratories and an engaging discussion on careers in science.

Accompanied by lecturers from the Department of Physiology and the Department of Biodiversity, the group of second- and third-year Biochemistry and Microbiology students had the opportunity to see first-hand how cutting-edge genomics and laboratory research are shaping healthcare and scientific discovery in South Africa.

The visit went far beyond showcasing KRISP’s stateof-the-art facilities. It was an opportunity to open meaningful conversations around career pathways, research opportunities, and postgraduate studies— empowering the next generation of scientists to envision how their passion for science could be translated into impactful careers.

Speaking about the motivation behind the trip, Hlabane Tshembo, Secretary of the SMLS Council, explained: “The students, as a group, try to organise an academic excursion every year to help broaden our horizons and the understanding we have of how

these industries and careers work outside of our textbooks and lectures.”

For many, the highlight of the visit was the chance to walk through the labs and experience science in action. As Ramaru Neo, SMLS Biodiversity Officer, reflected: “The lab tour was very insightful and it was exciting to see science in action, walking through the laboratory with the state-of-the-art technology around us.”

KRISP team members were equally inspired by the energy of the visit. “It was wonderful to see the students’ enthusiasm for science and their curiosity about the future. Their questions reminded us of why we do this work—not only to advance discovery today but also to inspire the scientists of tomorrow,” said Dr Amsha Viraragavan.

Building capacity and inspiring future leaders in science remain at the heart of our mission. Engaging with students at this formative stage allows us to share not only our work but also the possibilities that exist for young scientists in Africa. We extend our thanks to the University of Limpopo and the student organising committee, led by Hlabane Tshembo, for making this visit possible. We look forward to seeing these future scientists lead the way in advancing African research and discovery.

A Culture of Quality and Collaboration

Lab Excellence: A shared committment to producing top-notch results

photo: Supplied

The Centre for Epidemic Response and Innovation (CERI) has achieved an impressive milestone this year, scoring a perfect 100% in two challenging external quality assurance (EQA) tests. These tests, known as the 2025 Respiratory I Plus and Respiratory II EQA Schemes, were facilitated by Quality Control for Molecular Diagnostics (QCMD), an esteemed independent organisation dedicated to proficiency testing in the field of clinical molecular diagnostics. Let’s take a closer look at what this achievement means.

What Are EQA Challenges?

Think of external quality assurance challenges as report cards for laboratories. They measure how well labs can identify various viruses that cause respiratory illnesses, such as influenza and COVID-19. Hundreds of labs from around 40 countries took part in these tests, using a variety of samples: some contained well-known viruses, while others were free

of pathogens. CERI submitted its results for evaluation, and to everyone’s delight, the scores were perfect! CERI is one of the few laboratories in South Africa actively involved in monitoring respiratory viruses. Since the start of the year, we have released around 240 viral genomes to the public, contributing significantly to flu forecasting for the region.

Behind the Success: What Makes CERI Stand Out?

Dr Lavanya Singh, CERI’s Head of Laboratory, highlights that achieving a 100% score is not just a chance win but the result of dedication and rigorous practices ingrained into the lab’s culture. “Our laboratory has strict protocols that include positive and negative quality controls. This helps us keep track of our performance consistently,” she explains, emphasising the importance of using validated methods and welltrained personnel.

These practices help CERI maintain high standards, ensuring that every sample is handled with the utmost

care – from when it arrives at the lab to when the results are delivered.

The Importance of EQA Schemes for Continuous Improvement

Participation in EQA schemes, such as those offered by QCMD, is vital for CERI’s growth. These assessments push the lab to continually evaluate and refine internal processes. “They help us review our methods, equipment, and training protocols,” says Lavanya. “This feedback is crucial for our ISO/IEC 17025 Accreditation, as it provides an objective way to see how we measure up against peer labs globally.”

Building Trust and Reputation in Diagnostics

CERI’s achievement not only reflects on its internal quality but also strengthens its reputation in the molecular diagnostics field. “Having a solid score like this opens doors for future collaborations,” Lavanya notes. “It builds trust and credibility among local and

international partners, which is essential for securing grants and funding opportunities.”

A Culture of Quality and Collaboration

CERI’s approach to fostering a culture of quality has substantially evolved. “We have aligned the goals of our wet-lab and bioinformatics teams,” Lavanya explains. “This alignment nurtures a shared commitment to producing high-quality results.” The seamless communication between teams leads to valuable discussions on method validation and optimisation, creating an environment ripe for innovation.

In conclusion, CERI’s 100% scores in external quality assurance testing showcase a commitment to excellence that goes beyond numbers – it represents a collective effort in team training, process improvement, and a commitment to public health. With shared goals and collaboration at the heart of CERI’s operation, the laboratory stands ready to continue making significant contributions to the field of molecular diagnostics.

ABOVE: The CERI laboratory team, from left, Lucious Chabuka, Marije Hofstra, Yusasha Pillay, Kerwin Liedeman, Stepfan de Villiers, Tebogo Ramakutoane, Velda Wentzel, and Lavanya Singh.

MEDIA COVERAGE

Our work showcased in videos and featured on TV

Governments, Science & Africa’s Drug Discovery

How can governments help build a science-based economy? What does Africa’s journey in drug discovery look like, and how are Pan-African collaborations driving progress? In this #CERIseminar, hosted by Dr Richard Gordon, leading experts share their insights.

Watch the full video here: https://www.youtube.com/watch?v=Qxb8gyOkp8c

Medical Devices & Diagnostics in Africa

How do we strengthen Africa’s capacity to innovate, manufacture, and scale medical devices and diagnostics? In this #CERIseminar, leading voices from industry share insights into the opportunities and challenges of bringing healthcare solutions to market on the continent.

Watch the full video here: https://www.youtube.com/watch?v=t0UpCymDhms

Cape HealthTech Connect

Cape HealthTech Connect is a dynamic ecosystem of health and medical technology startups, researchers, and enterprises in the Western Cape of South Africa, with a strong focus on the Cape Town and Stellenbosch regions. The event is organised by Centre for Epidemic Response and Innovation (CERI), LaunchLab CERI-BIO, Stellenbosch Network, and INNOVUS at Stellenbosch University.

Watch the full video here: https://www.youtube.com/watch?v=1CGlQSzPXRM

The Power of Collaboration in Science

In this #RealTalkResearch episode, Prof Tulio de Oliveira highlights the power of collaboration in science. He explains why working beyond silos—by co-authoring, sharing ideas, and building partnerships—helps researchers grow. Collaboration not only advances knowledge but also teaches the balance of leading and following. As Prof de Oliveira says, “to be a good leader, you need to be a good follower.”

Watch the full video here: https://www.youtube.com/watch?v=Sk0_qAOIWGM

LaunchLab CERIBIO on eNCA

From eNCA: At LaunchLab CERIBIO, entrepreneurs are given access to affordable world-class laboratory space where they can test their biotechnology inventions. The laboratory will be operated in collaboration with Stellenbosch University’s Division for Innovation and Commercialisation.

Watch the full video here: https://www.youtube.com/watch?v=v2fkH2-ABRM

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