ENHANCING GENOMIC CAPACITY

text: Katrine Anker-Nilssen photos: Supplied

In September, Separations, in collaboration with CERI, hosted the African BioGenome Project (AfricaBP) Open Institute Southern Africa Regional Workshop, organised and funded by Separations. Facilitated by Natasha Kitchin and Jacques Potgieter from Separations, the workshop aimed to strengthen local capacity in vital areas: DNA isolation, quality control, library preparation, and whole genome sequencing data analysis—essential for generating and analysing genomic data.

The workshop combined theoretical knowledge with practical applications, covering DNA extraction, quality control using spectrophotometry and fluorometry, and foundational principles of library preparation and data analysis. “This aligns closely with AfricaBP’s mission to empower African scientists to generate and analyse genomic data within the continent,” Natasha explained.

Workshop sessions fostered active participation, with attendees sharing experiences, troubleshooting techniques, and discussing applications in their research contexts. Many questions cantered on improving DNA quality from challenging sample types and developing sequencing libraries for various platforms. A standout moment was witnessing participants gain confidence and independently complete DNA extraction and quality control by the workshop’s conclusion. The facilitators created a wellstructured program, offering detailed handouts on DNA isolation and quality control, thoroughly reviewing protocols, and designing engaging data analysis exercises. “Although keeping to the schedule was a squeeze, the enthusiasm and collaboration from participants made the experience overwhelmingly positive,” Natasha noted.

CERI provided excellent logistical support, ensuring smooth lab setup and timely material access. Lavanya Singh, Head of Laboratory at CERI, highlighted their commitment to advancing genomics research in Africa. She mentioned initiatives like the African STARS Fellowship aimed at cultivating the next generation of scientific leaders. “Partnerships and events like the AfricaBP workshop provide essential tools to promote innovation and nurture transdisciplinary research across the continent,” she added.

Addressing the challenges in African genomic research, Jacques pointed out that limited infrastructure and technical expertise remain significant obstacles. Workshops such as this provide crucial handson experience and help build a network of trained researchers throughout Africa. He encouraged participants to integrate the techniques learned into their research environments, noting plans for more advanced sequencing and data analysis sessions in the future.

Lavanya reiterated AfricaBP’s vision to leverage biodiversity genomics for sustainable management on the continent. She acknowledged that while genomic research in Africa holds immense potential—improving health outcomes and spurring innovation—it also confronts challenges like inadequate funding and a shortage of skilled personnel. “Workshops like this can address these issues by enhancing capacity and encouraging local knowledge transfer,” she said.

Jacques emphasised the inspiring coordinated effort of the AfricaBP project to generate valuable genomic data tailored to African challenges, fostering opportunities for local leadership in the field.

“Collaboration and continuous training are essential to making this a sustainable reality,” Natasha concluded, reinforcing the urgency for utilising available resources in genomics research. “It’s here, and it’s now,” Lavanya added, affirming that Africa is wellequipped to lead in this vital area.